Qilun Zhang, Xuting Shen, Xin Yuan, Jing Huang, Yaling Zhu, Tengteng Zhu, Tao Zhang, Haibo Wu, Qian Wu, Yinguang Fan, Jing Ni, Leilei Meng, Anyuan He, Chaowei Shi, Hao Li, Qingsong Hu, Jian Wang, Cheng Chang, Fan Huang, Fang Li, Meng Chen, Anding Liu, Shandong Ye, Mao Zheng, Haoshu Fang
Oxidative stress-induced lipid accumulation is mediated by lipid droplets (LDs) homeostasis, which sequester vulnerable unsaturated triglycerides into LDs to prevent further peroxidation. Here we identify the upregulation of lipopolysaccharide-binding protein (LBP) and its trafficking through LDs as a mechanism for modulating LD homeostasis in response to oxidative stress. Our results suggest that LBP induces lipid accumulation by controlling lipid-redox homeostasis through its lipid-capture activity, sorting unsaturated triglycerides into LDs...
April 13, 2024: Nature Communications