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https://www.readbyqxmd.com/read/29770163/ultrasound-guided-prolotherapy-with-polydeoxyribonucleotide-for-painful-rotator-cuff-tendinopathy
#1
Kyoungho Ryu, Dongchan Ko, Goeun Lim, Eugene Kim, Sung Hyun Lee
Background: Rotator cuff tendinopathy is a primary cause of shoulder pain and dysfunction. Several effective nonsurgical treatment methods have been described for chronic rotator cuff tendinopathy. Prolotherapy with polydeoxyribonucleotide (PDRN), which consists of active deoxyribonucleotide polymers that stimulate tissue repair, is a nonsurgical regenerative injection that may be a viable treatment option. The objective of this study was to assess the efficacy of PDRN in the treatment of chronic rotator cuff tendinopathy...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29768379/usefulness-of-polydeoxyribonucleotide-as-an-alternative-to-corticosteroids-in-patients-with-lateral-epicondyitis-a-case-series
#2
Goo Joo Lee, Donghwi Park
RATIONALE: Local corticosteroid injections are commonly used as an easy, cost-effective treatment for patients with lateral epicondylitis (LE). Despite their strong anti-inflammatory effect, repeated injections of corticosteroids are not recommended in LE because they can aggravate tearing of the tendons. PATIENT CONCERNS: A 65-year-old (Case1) man and a 59-year-old (Case2) man had a 2-month history of right lateral elbow pain exacerbation. DIAGNOSES: Lateral epicondylitis with hypervascularity of the common extensor tendon...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29665355/combination-therapy-with-polydeoxyribonucleotide-and-proton-pump-inhibitor-enhances-therapeutic-effectiveness-for-gastric-ulcer-in-rats
#3
Il-Gyu Ko, Sung-Eun Kim, Jun-Jang Jin, Lakkyong Hwang, Eun-Sang Ji, Chang-Ju Kim, Jin-Hee Han, In Taik Hong, Min Seop Kwak, Jin Young Yoon, Hyun Phil Shin, Jung Won Jeon
AIMS: The main action of proton pump inhibitors (PPIs) is to inhibit gastric acid secretion, and PPIs are widely used to treat gastric ulcer (GU). However, if the action of promoting gastric mucosal regeneration is added, the effectiveness of GU treatment can be enhanced. Thus, in order to improve the therapeutic effect on GU, we tried to develop combination therapy promoting regeneration in injured tissue besides suppressing gastric acid secretion. MAIN METHODS: Polydeoxyribonucleotide (PDRN) was selected to evaluate tissue regeneration, and pantoprazole was chosen as one of the PPIs...
April 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29609429/comparison-of-wound-healing-effects-between-oncorhynchus-keta-derived-polydeoxyribonucleotide-pdrn-and-oncorhynchus-mykiss-derived-pdrn
#4
Jong Hun Lee, Jin Woo Han, Jin Hwan Byun, Won Mi Lee, Min Ho Kim, Wen Hao Wu
BACKGROUND: Polydeoxyribonucleotide (PDRN) influencing cellular growth and differentiation is recognized to promote wound healing by stimulating tissue repair. Although PDRN can be extracted from human placentas, PDRN medications have recently been extracted from the semen of trout ( Oncorhynchus mykiss ) and salmon ( Oncorhynchus keta ). The present study was designed to evaluate the wound healing effects of O. keta -derived PDRN for injection (Rejuvenex) and PDRN cream (Rejuvenex Cream) in comparison with those of O...
March 2018: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29464170/adjuvant-therapy-for-revision-rhinoplasty-of-contracted-nose-using-polydeoxyribonucleotide-and-invasive-bipolar-radiofrequency
#5
Tae Hwan Ahn, Sung Bin Cho
Most cases of severely contracted nose require revision rhinoplasty and septoplasty, wherein preoperative and/or intraoperative expansion of nasal soft tissue is necessary for tension-free revision surgery. The present study aimed to evaluate the efficacy and safety of pre- and postoperative adjuvant therapy using polydeoxyribonucleotide (PDRN) and invasive, pulsed-type, bipolar, alternating current radiofrequency (RF) for revision surgery of a contracted nose. In total, 30 patients were treated with 16 sessions (8 preoperative sessions and 8 postoperative sessions) of intralesional injection of PDRN and invasive RF treatment using microneedle electrodes at 1-week intervals...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29373371/effect-of-polydeoxyribonucleotide-injection-in-a-patient-with-carpal-tunnel-syndrome-a-case-report
#6
Jin-Sung Park, Donghwi Park
Ultrasound-guided corticosteroid injection into the carpal tunnel is widely performed for the management of carpal tunnel syndrome (CTS). However, this injection may worsen the condition in patients with type 2 diabetes mellitus (DM). Polydeoxyribonucleotide (PDRN) was recently recognized as a substitute for corticosteroid due to its anti-inflammatory effects. A 41-year-old woman with type 2 DM was admitted to our rehabilitation clinic with a 1-month history of numbness and tingling in her right hand and first 3 fingers tips...
January 25, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29302765/anti-inflammatory-effect-of-dna-polymeric-molecules-in-a-cell-model-of-osteoarthritis
#7
Ahreum Baek, MinGi Kim, Sung Hoon Kim, Sung-Rae Cho, Hyun Jung Kim
The DNA polymeric molecules polydeoxynucleotide (PDRN) and polynucleotide (PN) can be used as new alternative treatment for osteoarthritis (OA); however, the underlying mechanisms are not fully understood. In this study, we investigated the effect of PDRN and PN on gene-expression profiles in a cell model of OA using transcriptome analysis. Under hypoxic conditions, human chondrosarcoma cells were stressed for 24 h in the presence of interleukin (IL)-1β and subsequently treated with PDRN, PN, or hyaluronic acid (HA) for another 24 h, followed by transcriptome analysis...
March 2018: Inflammation
https://www.readbyqxmd.com/read/29202574/effect-of-biostimulation-on-oral-fibroblast-a-pilot-study
#8
A Palmieri, A Avantaggiato, F Cura, R Papalia, M Casale, F Bressi, L Scapoli
Bio-stimulation is a technique in aesthetic medicine in which different drugs such as nucleotides, antioxidants and glucosaminoglycans precursors are injected in the dermis to improving the anabolic function of dermal fibroblasts, i.e., protein synthesis, replication and production of extracellular matrix components. It can be achieved with multiple intra-dermal injections, using two protocols: 1) Polydeoxyribonucleotide (PDRN) plus glucosamine sulphate (Gluc); 2) N-acetylcysteine (NAC) and amino acids (Aa) (named Bio- NAC procedure)...
December 27, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29145323/the-effectiveness-of-2-consecutive-intra-articular-polydeoxyribonucleotide-injections-compared-with-intra-articular-triamcinolone-for-hemiplegic-shoulder-pain-a-strobe-complaint-retrospective-study
#9
COMPARATIVE STUDY
Donghwi Park, Kwang Jae Yu, Ju Young Cho, Seung Beom Woo, Junu Park, Zeeihn Lee, Jong Min Kim
The aim of this study was to investigate the effects of intra-articular injection of polydeoxyribonucleotide (PDRN), compared with intraarticular triamcinolone (TA) injection, in subacute stroke patients with hemiplegic shoulder pain (HSP).Participants were subacute stroke patients with HSP who had undergone 2 consecutive intra-articular injections of TA or PDRN.Numeric rating scale (NRS) and passive range of motion (PROM) of hemiplegic shoulder were evaluated until 4 weeks after 2nd injection.In the results, there were significant improvements in all PROM measures 2 weeks after the second injection, compared with pre-injection results, in both groups (P < ...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145316/application-of-ultrasound-guided-c5-nerve-root-block-using-polydeoxyribonucleotide-in-traumatic-c5-nerve-root-injury-caused-by-fracture-of-the-articular-process-of-the-cervical-spine-a-case-report
#10
Donghwi Park
RATIONALE: Cervical nerve root injury is one of the complications of traumatic cervical spine fracture. Although one of the most effective treatments to reduce inflammation in nerve root injuries is the use of corticosteroids or nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and NSAIDs can inhibit bone healing. So, when nerve injury accompanies bone fractures, corticosteroids and NSAIDs have limitations as therapeutic agents. However, polydeoxyribonucleotide (PDRN) may be useful in the treatment of neuropathy or musculoskeletal pain patients with contraindication of the use of corticosteroids because of its anti-inflammatory effect, as revealed in previous studies...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29082254/sodium-dna-for-bone-tissue-regeneration-an-experimental-study-in-rat-calvaria
#11
Barbara Buffoli, Gaia Favero, Elisa Borsani, Ramon Boninsegna, Guido Sancassani, Mauro Labanca, Rita Rezzani, Pier Francesco Nocini, Massimo Albanese, Luigi Fabrizio Rodella
Surgical techniques in dental and maxillofacial surgery request fast bone tissue regeneration, so there is a significant need to improve therapy for bone regeneration. Several studies have recently underlined the importance of nucleotides and nucleosides to increase cell proliferation and activity; in particular, the ability of polydeoxyribonucleotide (PDRN) to induce growth and activity of human osteoblasts was demonstrated. Sodium-DNA is the deoxyribonucleic acid (DNA) extracted from the gonadic tissue of male sturgeon and then purified, depolymerized, and neutralized with sodium hydroxide...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29076318/polydeoxyribonucleotide-improves-peripheral-tissue-oxygenation-and-accelerates-angiogenesis-in-diabetic-foot-ulcers
#12
Seoyoung Kim, Junhyung Kim, Jaehoon Choi, Woonhyeok Jeong, Sunyoung Kwon
BACKGROUND: Polydeoxyribonucleotide (PDRN) is known to have anti-inflammatory and angiogenic effects and to accelerate wound healing. The aim of this study was to investigate whether PDRN could improve peripheral tissue oxygenation and angiogenesis in diabetic foot ulcers. METHODS: This was a prospective randomized controlled clinical trial. Twenty patients with a non-healing diabetic foot ulcer were randomly distributed into a control group (n=10) and a PDRN group (n=10)...
November 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/29076317/salvage-of-unilateral-complete-ear-amputation-with-continuous-local-hyperbaric-oxygen-platelet-rich-plasma-and-polydeoxyribonucleotide-without-micro-revascularization
#13
Sang Keon Lee, Yoon Min Lim, Dae Hyun Lew, Seung Yong Song
In many cases of complete ear amputation, microvascular surgery is required for tissue perfusion and organ survival. However, microvascular reconstruction is not always feasible in the absence of suitable vessels. Here, we present the case of a 76-year-old man who underwent complete amputation of the left ear after a collapse at home because of cardiogenic syncope. He was treated with primary replantation and underwent a postoperative salvage course including continuous local hyperbaric oxygen therapy (HBOT), platelet-rich plasma (PRP) injections, and polydeoxyribonucleotide (PDRN) injections...
November 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/29069005/effect-of-polydeoxyribonucleotide-injection-on-pes-anserine-bursitis-a-case-report
#14
Jong-Uk Mun, Hyung R Cho, Sae M Bae, Soo K Park, Soo L Choi, Mi S Seo, Young S Lim, Soo H Woo Rn, Young U Kim
RATIONALE: Pes anserine (PA) bursitis is an inflammatory condition of the medial knee. The PA bursa becomes more painful when infected, damaged, or irritated. Although various treatment options have been attempted to treat PA bursitis, optimal treatments are still debated. This study aims to investigate the effect of polydeoxyribonucleotide (PDRN) injection on reducing pain and inflammation in a patient presenting with PA bursitis. PATIENT CONCERNS: A 50-year-old female patient was admitted to our pain clinic with symptoms of tenderness and pain over the medial knee...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28928654/adenosine-receptor-stimulation-improves-glucocorticoid-induced-osteoporosis-in-a-rat-model
#15
Gabriele Pizzino, Natasha Irrera, Federica Galfo, Giacomo Oteri, Marco Atteritano, Giovanni Pallio, Federica Mannino, Angelica D'Amore, Enrica Pellegrino, Federica Aliquò, Giuseppe P Anastasi, Giuseppina Cutroneo, Francesco Squadrito, Domenica Altavilla, Alessandra Bitto
Glucocorticoid-induced osteoporosis (GIO) is a secondary cause of bone loss. Bisphosphonates approved for GIO, might induce jaw osteonecrosis; thus additional therapeutics are required. Adenosine receptor agonists are positive regulators of bone remodeling, thus the efficacy of adenosine receptor stimulation for treating GIO was tested. In a preventive study GIO was induced in Sprague-Dawley rats by methylprednisolone (MP) for 60 days. Animals were randomly assigned to receive polydeoxyribonucleotide (PDRN), an adenosine A2 receptor agonist, or PDRN and DMPX (3,7-dimethyl-1-propargylxanthine, an A2 antagonist), or vehicle (0...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28837114/polydeoxyribonucleotide-ameliorates-lipopolysaccharide-induced-lung-injury-by-inhibiting-apoptotic-cell-death-in-rats
#16
Jin An, So Hee Park, Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Eun-Sang Ji, Sang-Hoon Kim, Chang-Ju Kim, So Young Park, Jae-Joon Hwang, Cheon Woong Choi
Lung injury is characterized by diffuse lung inflammation, alveolar-capillary destruction, and alveolar flooding, resulting in respiratory failure. Polydexyribonucleotide (PDRN) has an anti-inflammatory effect, decreasing inflammatory cytokines, and suppressing apoptosis. Thus, we investigated its efficacy in the treatment of lung injury, which was induced in rats using lipopolysaccharide (LPS). Rats were randomly divided into three groups according to sacrifice time, and each group split into control, lung injury-induced, and lung injury-induced + PDRN-treated groups...
August 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28771195/scar-prevention-and-enhanced-wound-healing-induced-by-polydeoxyribonucleotide-in-a-rat-incisional-wound-healing-model
#17
Woonhyeok Jeong, Chae Eun Yang, Tai Suk Roh, Jun Hyung Kim, Ju Hee Lee, Won Jai Lee
High-mobility group box protein-1 (HMGB-1) plays a central role in the inflammatory network, and uncontrolled chronic inflammation can lead to excessive scarring. The aim of this study was to evaluate the anti-inflammatory effects of polydeoxyribonucleotide (PDRN) on scar formation. Sprague-Dawley rats (n = 30) underwent dorsal excision of the skin, followed by skin repair. PDRN (8 mg/kg) was administered via intraperitoneal injection for three (PDRN-3 group, n = 8) or seven (PDRN-7 group, n = 8) days, and HMGB-1 was administered via intradermal injection in addition to PDRN treatment for three days (PDRN-3+HMGB-1 group; n = 6)...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28640096/effect-of-transforaminal-epidural-polydeoxyribonucleotide-injections-on-lumbosacral-radiculopathy-a-case-report
#18
Keum Nae Kang, Tae Woong Kim, Jin Woo Koh, Han Byeol Oh, Jong-Uk Mun, Mi Sook Seo, Young Uk Kim
RATIONALE: Transforaminal epidural glucocorticoids administration is widely performed for the management of lumbosacral radiculopathy. However, it may worsen the condition of patients with type 2 diabetes mellitus (DM). Polydeoxyribonucleotide (PDRN) was recently noted as a substitute for glucocorticoids. PATIENT CONCERNS: A 44-year-old male patient was admitted to our pain clinic with symptoms of low back pain with severe pain and tingling sensation of left posterolateral leg...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28491036/pharmacological-activity-and-clinical-use-of-pdrn
#19
REVIEW
Francesco Squadrito, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Giovanni Pallio, Letteria Minutoli, Domenica Altavilla
PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory. These therapeutic properties suggest its use in regenerative medicine and in diabetic foot ulcers. PDRN holds a mixture of deoxyribonucleotides with molecular weights ranging between 50 and 1,500 KDa, it is derived from a controlled purification and sterilization process of Oncorhynchus mykiss (Salmon Trout) or Oncorhynchus keta (Chum Salmon) sperm DNA. The procedure guarantees the absence of active protein and peptides that may cause immune reactions...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28002322/the-effect-of-polydeoxyribonucleotide-prolotherapy-on-posterior-tibial-tendon-dysfunction-after-ankle-syndesmotic-surgery-a-case-report
#20
Tae-Ha Lim, Hyung Rae Cho, Keum Nae Kang, Chang Joon Rhyu, Sung Won Chon, Young Su Lim, Jee In Yoo, Jung-Won Kim, Young Uk Kim
RATIONALE: Ankle syndesmotic injuries occasionally require long-term therapy for recovery and can result in tendon injury. Posterior tibial tendon dysfunction (PTTD) is an acquired deformity that can cause flatfoot deformity. The current nonoperative management of PTTD includes nonsteroidal antiinflammatory drugs (NSAIDs), orthopedic devices. Although various treatment options have been attempted, optimal treatments for each stage of the condition are debated. Polydeoxyribonucleotide (PDRN) is effective in healing of chronic wounds associated with tissue damage by attracting tissue growth factors...
December 2016: Medicine (Baltimore)
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