keyword
https://read.qxmd.com/read/38244736/a-multifunctional-composite-nanoparticle-with-antibacterial-activities-anti-inflammatory-and-angiogenesis-for-diabetic-wound-healing
#1
JOURNAL ARTICLE
Xiaoming Li, Shuang Qu, Qiuhong Ouyang, Feng Qin, Jimin Guo, Meng Qin, Jianjun Zhang
The treatment of chronic diabetic wounds remains challenging due to the rapid bacterial infection, severe inflammation, and insufficient angiogenesis. To address these challenges, a novel multifunctional composite nanoparticle is developed by co-assembling antisolvent-induced co-assembling silk-fibroin ε-poly-l-Lysine nanoparticles (nSF-EPL) and further assembling nSF-EPL with polydeoxyribonucleotide (PDRN) and exosome derived from human umbilical mesenchymal stem cells (Exo). Owing to the modification of EPL, PDRN and Exo, composite nanoparticles exhibited synergistic antibacterial action, anti-inflammatory and angiogenesis, which can significantly benefit for promoting wound healing...
January 18, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38171324/adenosine-a2a-receptor-agonist-polydeoxyribonucleotide-treatment-improves-locomotor-function-and-thermal-hyperalgesia-following-neuropathic-pain-in-rats
#2
JOURNAL ARTICLE
Ye Chan Joo, Jun Young Chung, Soon Oh Kwon, Jin Hee Han
PURPOSE: Lithotomy position has been widely used in the various urologic surgery. Occasionally sensory and motor problems of the lower extremities are occurred due to the lithotomy position and these deficits may be related with sciatic nerve injury (SNI). Inflammatory process is a factor to induce functional impairment after SNI. Therefore, we evaluated the role of adenosine A2A receptor agonists, polydeoxyribonucleotide (PDRN) showing anti-inflammatory effect on locomotor function following SNI in rats...
December 2023: International Neurourology Journal
https://read.qxmd.com/read/38132418/polydeoxyribonucleotides-pre-clinical-findings-in-bone-healing-a-scoping-review
#3
REVIEW
Mattia Manfredini, Pier Paolo Poli, Mario Beretta, Matteo Pellegrini, Federica Eugenia Salina, Carlo Maiorana
AIM: Polydeoxyribonucleotide (PDRN) is a chain-like polymer derived from DNA. Recent in vitro and animal studies have showcased the beneficial impacts of PDRN on the process of bone mending, whether used on its own or in conjunction with other substances that aid in regeneration. This scoping review aims to synthesize the current understanding of how PDRNs influence bone healing. MATERIALS AND METHODS: The studies included in the screening procedure were randomized controlled clinical trials (RCTs), both retrospective and prospective case-control studies, as well as in vitro and in vivo investigations...
December 4, 2023: Dentistry Journal
https://read.qxmd.com/read/38029897/multifunctional-alginate-polydeoxyribonucleotide-hydrogels-for-promoting-diabetic-wound-healing
#4
JOURNAL ARTICLE
S H S Dananjaya, Nadeeka Bandara, Ilandarage Menu Neelaka Molagoda, W M Gayashani Sandamalika, Dukgyu Kim, Nipuni Ganepola, Anoja P Attanayake, Dongrack Choi
A multifunctional alginate/PDRN hydrogel system by ionic crosslinking and the Schiff base reaction between oxidized alginate (OA) and PDRN was developed in the present study. Biocompatibility assessment of the PDRN-loaded OA hydrogels showed a significant enhancement in cell viability in human dermal fibroblast (HDF) cells. In addition, hydrogels showed migratory, anti-inflammatory, intracellular reactive oxygen species scavenging, and anti-apoptotic activities. In vivo studies using a streptozotocin-induced diabetic Wister rat model indicated that OA-4PDRN had the highest percentage of wound closure (96...
November 27, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37976129/conservative-management-of-partial-thickness-rotator-cuff-tears-a-systematic-review
#5
JOURNAL ARTICLE
Umile Giuseppe Longo, Alberto Lalli, Giovanna Medina, Nicola Maffulli
BACKGROUND: Conservative management has emerged as an attractive option for partial thickness rotator cuff tears (PT-RCTs). A single algorithmic treatment strategy for patients with symptomatic PT-RCT has not yet been developed. This systematic review aims to ascertain whether a conservative approach to PT-RCTs yields positive results in terms of clinical outcomes and functional recovery. METHODS: This is a systematic review of the literature on patients with PT-RCTs receiving conservative treatment with physiotherapy, platelet-rich plasma (PRP) injections, collagen injections, hyaluronic acid (HA) injections, or corticosteroids injections coupled with polydeoxyribonucleotide (PDRN)...
September 1, 2023: Sports Medicine and Arthroscopy Review
https://read.qxmd.com/read/37959659/analysis-of-skin-regeneration-and-barrier-improvement-efficacy-of-polydeoxyribonucleotide-isolated-from-panax-ginseng-c-a-mey-adventitious-root
#6
JOURNAL ARTICLE
Kwang-Soo Lee, Soyeon Lee, Hyesoo Wang, Geonhee Lee, Seolyeong Kim, Yang-Hwan Ryu, Nicole Hyesoo Chang, Yong-Won Kang
Polydeoxyribonucleotide (PDRN) has the ability to regenerate skin cells and improve the skin barrier and wound healing. This study investigated the possibility of replacing animal-derived PDRN with plant-derived PDRN. To test this, the adventitious roots of Korean ginseng (Panax ginseng C.A. Meyer), which is commonly used to treat various diseases, were suspension-cultivated through tissue culture; subsequently, PDRN was purified using microfluidization, an ultra-high-pressure physical grinding method. The results showed that purified Panax PDRN was effective in healing skin wounds and enhancing the skin barrier...
October 24, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37836631/a-photocurable-polysaccharide-based-hydrogel-delivery-of-polydeoxyribonucleotide-loaded-vectors-for-wound-treatment
#7
JOURNAL ARTICLE
Zonghui Li, Xiaojun Ma, Qiang Gao, Mingxin Zhang, Hao Hu
The wounds caused by war, accidents, and diseases require timely and effective treatment. Polysaccharides, as natural macromolecules, have good biocompatibility and unique functions, and are excellent substrates for constructing new wound dressings. Short-chain chitosan (SCS) has good water solubility and, importantly, retains a large number of active amino groups. We first introduce double bonds to SCS. This chitosan derivative can be entangled with sodium alginate (SA) through electrostatic interaction. The flowing sol can be applied to a wound with an irregular shape...
September 24, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37803058/effect-of-polydeoxyribonucleotide-on-early-bone-formation-in-lateral-bone-augmentation-with-immediate-implant-placement-an-experimental-in-vivo-study
#8
JOURNAL ARTICLE
Dongseob Lee, Jungwon Lee, Yang-Jo Seol, Yong-Moo Lee, Ki-Tae Koo
This study investigated early bone formation using collagenated biphasic calcium phosphate (CBCP) with or without polynucleotide (PDRN). Third (P3) or fourth (P4) premolars of six male beagle dogs were extracted and 5-mm-high dehiscence defects were created, followed by 3D-printed implant placement. The buccal bone defects were grafted with (i) CBCP and collagen membrane or (ii) CBCP soaked in polydeoxyribonucleotide (CBCP/PDRN) and collagen membrane. Samples of the experimental sites were harvested at 2- and 6-weeks post-surgery...
October 6, 2023: Scientific Reports
https://read.qxmd.com/read/37689303/development-and-characterization-of-polydeoxyribonucleotide-pdrn-loaded-chitosan-polyplex-in-vitro-and-in-vivo-evaluation-of-wound-healing-activity
#9
JOURNAL ARTICLE
S H S Dananjaya, K G P Madushani, Jeewani Dilrukshi, Nayomi D De Silva, W M Gayashani Sandamalika, Dukgyu Kim, Dongrack Choi, Mahanama De Zoysa, Anoja P Attanayake
Polydeoxyribonucleotide (PDRN) is an accelerated diabetic wound healing therapy with promising abilities to promote cell growth, angiogenesis, collagen synthesis, and reduce inflammation where its sustainable delivery and release behavior is critical to ensure effective wound healing properties. Therefore, a nanopolyplex was developed here, by encapsulating PDRN with chitosan to affirm its delivery systematically. The physicochemical characterization revealed its successful encapsulation which facilitates the gradual release of PDRN...
December 31, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37681354/effect-of-polydeoxyribonucleotide-with-xenogeneic-collagen-matrix-on-gingival-phenotype-modification-a-pilot-preclinical-study
#10
JOURNAL ARTICLE
Hyun-Chang Lim, Chang-Hoon Kim, Han-Kyu Lee, Gyewon Jeon, Yeek Herr, Jong-Hyuk Chung
PURPOSE: To investigate the effect of xenogeneic collagen matrix (XCM) with polydeoxyribonucleotide (PDRN) for gingival phenotype modification compared to autogenous connective tissue graft. METHODS: Five mongrel dogs were used in this study. Box-type gingival defects were surgically created bilaterally on the maxillary canines 8 weeks before gingival augmentation. A coronally positioned flap was performed with either a subepithelial connective tissue graft (SCTG) or XCM with PDRN (2...
July 7, 2023: Journal of Periodontal & Implant Science
https://read.qxmd.com/read/37629001/polydeoxyribonucleotide-and-shock-wave-therapy-sequence-efficacy-in-regenerating-immobilized-rabbit-calf-muscles
#11
JOURNAL ARTICLE
Yoon-Jin Lee, Yong Suk Moon, Dong Rak Kwon, Sung Cheol Cho, Eun Ho Kim
This study primarily aimed to investigate the combined effects of polydeoxyribonucleotide (PDRN) and extracorporeal shock wave therapy (ESWT) sequences on the regenerative processes in atrophied animal muscles. Thirty male New Zealand rabbits, aged 12 weeks, were divided into five groups: normal saline (Group 1), PDRN (Group 2), ESWT (Group 3), PDRN injection before ESWT (Group 4), and PDRN injection after ESWT (Group 5). After 2 weeks of cast immobilization, the respective treatments were administered to the atrophied calf muscles...
August 15, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37589166/anti-inflammatory-effect-of-polydeoxyribonucleotides-pdrn-extracted-from-red-alga-porphyra-sp-ps-pdrn-in-raw-264-7-macrophages-stimulated-with-escherichia-coli-lipopolysaccharides-a-comparative-study-with-commercial-pdrn
#12
JOURNAL ARTICLE
Tae-Hee Kim, Seong-Yeong Heo, Ji Sung Han, Won-Kyo Jung
Polydeoxyribonucleotide (PDRN) is a DNA-derived drug extracted from the sperm cells of Oncorhynchus mykiss or O. keta. PDRN exhibits wound healing and anti-inflammatory activities by activating adenosine A2A receptor and salvage pathways. However, commercial PDRN products (e.g., Placentex, Rejuvenex, and HiDr) have limitations as they are exclusively extracted O. mykiss and O. keta, which are expensive and can only be used as extraction sources during a specific period when their sperm cells are activated. Therefore, this study aimed to extract PDRN from Porphyra sp...
October 2023: Cell Biochemistry and Function
https://read.qxmd.com/read/37379642/the-impact-of-particulate-matters-on-apoptosis-in-various-organs-mechanistic-and-therapeutic-perspectives
#13
REVIEW
Seyed Mohsen Aghaei-Zarch, Amir Hosein Sanjari Nia, Morteza Nouri, Fatemehsadat Mousavinasab, Sajad Najafi, Saeed Bagheri-Mohammadi, Fatemehsadat Aghaei-Zarch, Ali Toolabi, Hassan Rasoulzadeh, Jalaledin Ghanavi, Masomeh Nasiri Moghadam, Mehrdad Talebi
Ecological air contamination is the non-homogenous suspension of insoluble particles into gas or/and liquid fluids known as particulate matter (PM). It has been discovered that exposure to PM can cause serious cellular defects, followed by tissue damage known as cellular stress. Apoptosis is a homeostatic and regulated phenomenon associated with distinguished physiological actions inclusive of organ and tissue generation, aging, and development. Moreover, it has been proposed that the deregulation of apoptotic performs an active role in the occurrence of many disorders, such as autoimmune disease, neurodegenerative, and malignant, in the human population...
June 26, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37373237/targeting-adenosine-signalling-in-knee-chondropathy-the-combined-action-of-polydeoxyribonucleotide-and-pulsed-electromagnetic-fields-a-current-concept-review
#14
REVIEW
Lorenzo Moretti, Davide Bizzoca, Alessandro Geronimo, Andrea Michele Abbaticchio, Francesco Luca Moretti, Arianna Carlet, Francesco Fischetti, Biagio Moretti
Chondropathy of the knee is one of the most frequent degenerative cartilage pathologies with advancing age. Scientific research has, in recent years, advanced new therapies that target adenosine A2 receptors, which play a significant role in human health against many disease states by activating different protective effects against cell sufferance and damage. Among these, it has been observed that intra-articular injections of polydeoxyribonucleotides (PDRN) and Pulsed Electromagnetic Fields (PEMF) can stimulate the adenosine signal, with significant regenerative and healing effects...
June 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37350391/polydeoxyribonucleotide-exerts-opposing-effects-on-erk-activity-in-human-skin-keratinocytes-and-fibroblasts
#15
JOURNAL ARTICLE
Sun Mee Shin, Eun Joo Baek, Kwang Ho Kim, Kwang Joong Kim, Eun Joo Park
Polydeoxyribonucleotide (PDRN) is a mixture of deoxyribonucleotides. It serves as an anti‑inflammatory and tissue‑regenerating agent. The mitogen‑activated protein kinase pathway modulates cell growth and collagen accumulation. It also regulates inflammation by suppressing the expression of proinflammatory cytokines. In the present study, it was attempted to elucidate the molecular mechanism of PDRN in skin healing by confirming the effects of PDRN treatment on skin keratinocytes and fibroblasts, and by assessing the levels of collagen and inflammatory cytokines regulated by the extracellular signal‑regulated kinase (ERK) pathway...
August 2023: Molecular Medicine Reports
https://read.qxmd.com/read/37309557/comparison-of-corneal-epithelial-wound-healing-between-topical-rci001-solcoseryl-and-polydeoxyribonucleotide-in-the-murine-ocular-alkali-burn-model
#16
JOURNAL ARTICLE
Myung-Sun Song, Young Ah Ku, Seunghoon Kim, Myung Hee Chung, Yong Ho Kim, Dong Hyun Kim
PURPOSE: To compare the corneal epithelial wound healing effects of RCI001, Solcoseryl, and polydeoxyribonucleotide (PDRN) in a rat alkali burn model. METHODS: In 40 male Sprague-Dawley rats, we induced alkali burn using filter paper soaked in 0.2N sodium hydroxide. The rats were then treated with topical 0.5% RCI001, 1.0% RCI001, Solcoseryl, or PDRN twice a day for 2 weeks. Corneal epithelial integrity and epithelial healing rate were measured at day 0, 3, 5, 7, 10, and 14...
June 2023: Korean Journal of Ophthalmology: KJO
https://read.qxmd.com/read/37209541/multimodal-therapy-strategy-based-on-a-bioactive-hydrogel-for-repair-of-spinal-cord-injury
#17
JOURNAL ARTICLE
Eun Ji Roh, Da-Seul Kim, Jun Hyuk Kim, Chang Su Lim, Hyemin Choi, Su Yeon Kwon, So-Yeon Park, Jun Young Kim, Hyun-Mun Kim, Dong-Youn Hwang, Dong Keun Han, Inbo Han
Traumatic spinal cord injury results in permanent and serious neurological impairment, but there is no effective treatment yet. Tissue engineering approaches offer great potential for the treatment of SCI, but spinal cord complexity poses great challenges. In this study, the composite scaffold consists of a hyaluronic acid-based hydrogel, decellularized brain matrix (DBM), and bioactive compounds such as polydeoxyribonucleotide (PDRN), tumor necrosis factor-α/interferon-γ primed mesenchymal stem cell-derived extracellular vesicles (TI-EVs), and human embryonic stem cell-derived neural progenitor cells (NPC)...
May 11, 2023: Biomaterials
https://read.qxmd.com/read/37189808/intramuscular-polydeoxyribonucleotides-in-fibrotic-and-atrophic-localized-scleroderma-an-explorative-prospective-cohort-study
#18
JOURNAL ARTICLE
Maurizio Romagnuolo, Chiara Moltrasio, Angelo Valerio Marzano, Gianluca Nazzaro, Simona Muratori, Sebastiano Recalcati
Effective options in the quiescent, scantily inflammatory phase of localized scleroderma (morphea) are lacking. A cohort study in patients with histologically confirmed fibroatrophic morphea explored the therapeutic value of the anti-dystrophic A2A adenosine agonist polydeoxyribonucleotide (PDRN, one daily 5.625 mg/3 mL ampoule for 90 days with a three-month follow-up). Primary efficacy endpoints: Localized Scleroderma Cutaneous Assessment Tool mLoSSI and mLoSDI subscores for disease activity and damage in eighteen areas; Physicians Global Assessment for Activity (PGA-A) and Damage (PGA-D) VAS scores; skin echography...
April 17, 2023: Biomedicines
https://read.qxmd.com/read/37045900/therapeutic-effects-of-polydeoxyribonucleotide-in-an-in-vitro-neuronal-model-of-ischemia-reperfusion-injury
#19
JOURNAL ARTICLE
Seongmoon Jo, Ahreum Baek, Yoonhee Cho, Sung Hoon Kim, Dawoon Baek, Jihye Hwang, Sung-Rae Cho, Hyun Jung Kim
Polydeoxyribonucleotide (PDRN) is an agonist that selectively stimulates adenosine A2A receptor (ADORA2A), which suppresses inflammatory responses. Ischemia/reperfusion (I/R) injury plays a major role in the pathogenesis of ischemic stroke by inducing neuroinflammation. Therefore, this study aimed to investigate the therapeutic effects of PDRN in an in vitro I/R injury model. The in vitro model was established with differentiated Neuro-2a cells under oxygen and glucose deprivation condition. The cells were treated with PDRN for 24 h under reoxygenation condition...
April 12, 2023: Scientific Reports
https://read.qxmd.com/read/36969699/multi-modulation-of-immune-inflammatory-response-using-bioactive-molecule-integrated-plga-composite-for-spinal-fusion
#20
JOURNAL ARTICLE
Hye Yeong Lee, Da-Seul Kim, Gwang Yong Hwang, Jun-Kyu Lee, Hye-Lan Lee, Ji-Won Jung, Sae Yeon Hwang, Seung-Woon Baek, Sol Lip Yoon, Yoon Ha, Keung Nyun Kim, Inbo Han, Dong Keun Han, Chang Kyu Lee
Despite current developments in bone substitute technology for spinal fusion, there is a lack of adequate materials for bone regeneration in clinical applications. Recombinant human bone morphogenetic protein-2 (rhBMP-2) is commercially available, but a severe inflammatory response is a known side effect. Bone graft substitutes that enhance osteogenesis without adverse effects are needed. We developed a bioactive molecule-laden PLGA composite with multi-modulation for bone fusion. This bioresorbable composite scaffold was considered for bone tissue engineering...
April 2023: Materials today. Bio
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