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https://www.readbyqxmd.com/read/28540988/pathologic-impact-of-insulin-resistance-and-sensitivity-on-the-severity-of-liver-histopathology-in-pediatric-non-alcoholic-steatohepatitis
#1
Byung Han Park, Jung Min Yoon, Ja Hye Kim, Jin Hwa Moon, Young Ho Lee, Se Min Jang, Yong Joo Kim
PURPOSE: Insulin resistance (IR) has an important role in the development of non-alcoholic steatohepatitis (NASH). We aimed to analyze the association between liver histopathology and IR in pediatric patients with NASH. MATERIALS AND METHODS: In 24 children with non-alcoholic fatty liver disease (NAFLD), we investigated whether the hepatic pathologic characteristics have relations with following three biochemical indices; IR index including homeostasis model assessment of IR (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and insulin sensitivity indices-free fatty acid (ISI-FFA)...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28538090/late-effects-in-pediatric-high-risk-neuroblastoma-survivors-after-intensive-induction-chemotherapy-followed-by-myeloablative-consolidation-chemotherapy-and-triple-autologous-stem-cell-transplants
#2
Amy E Armstrong, Karina Danner-Koptik, Shannon Golden, Jennifer Schneiderman, Morris Kletzel, Jennifer Reichek, Yasmin Gosiengfiao
Multimodal treatment in high-risk neuroblastoma has modestly improved survival; limited data exist on the late effects from these regimens. We report the sequelae of treatment incorporating 3 consecutive cycles of high-dose therapy and autologous stem cell transplants (ASCTs) without the use of total body irradiation (TBI). We reviewed the medical records of 61 patients treated on or following the Chicago Pilot 2 protocol between 1991 and 2008. Of the 25 patients who are alive (41%), 19 had near complete data to report...
May 23, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28535943/pragmatic-approach-to-intersex-including-genital-ambiguity-in-the-newborn
#3
Kanthi Bangalore Krishna, Christopher P Houk, Peter A Lee
The evaluation and management of a newborn with ambiguous genitalia must be undertaken as quickly as possible and with great sensitivity for the child's family. Where possible, a comprehensive team approach with a pediatric urologist, endocrinologist, geneticist, neonatologist, and child psychiatrist/psychologist should work closely with the family to establish the diagnosis and determine gender. Although the preferred gender assignment is not always clear, a thorough examination of endocrine function, karyotype, and potential for fertility should guide the determination...
May 20, 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/28525404/growth-hormone-treatment-for-growth-hormone-deficiency-and-idiopathic-short-stature-new-guidelines-shaped-by-the-presence-and-absence-of-evidence
#4
Adda Grimberg, David B Allen
PURPOSE OF REVIEW: The Pediatric Endocrine Society recently published new guidelines for the use of human growth hormone (hGH) and human insulin-like growth factor-I (hIGF-I) treatment for growth hormone deficiency, idiopathic short stature, and primary IGF-I deficiency in children and adolescents. This review places the new guidelines in historical contexts of the life cycle of hGH and the evolution of US health care, and highlights their future implications. RECENT FINDINGS: The new hGH guidelines, the first to be created by the Grading of Recommendations Assessment, Development and Evaluation approach, are more conservative than their predecessors...
May 18, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28508616/ultrasound-elastography-in-pediatric-congenital-hypothyroid-patients
#5
Mehmet Akif Sarıca, Tahir Dalkıran, Mehmet Sait Menzilcioğlu, Mahmut Duymuş, Nursel Yurttutan
OBJECTIVES: Congenital hypothyroidism (CH) is most frequently encountered in newborns as an endocrine disorder characterized by thyroid hormone deficiency, and is one of the most common reasons for preventable mental retardation. This prospective study was designed to detect the pediatric occurrences of CH followed as euthyroid, with no anomalies detected via US on the gray scale, in comparison with a pediatric group with normal levels. METHODS: A total of 42 apparently healthy children with no thyroid disorder (Group 1) and 54 euthyroid CH (Group 2) using thyroid hormone were included in this study...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28508610/meeting-reports-2016-annual-meeting-of-the-pediatric-endocrine-society-baltimore-md-april-29-may-2-2016-selected-highlights
#6
Alaina Vidmar, Jonathan Weber, Rajeev Thirunagari, Sungeeta Agrawal, Madhia Shahid
No abstract text is available yet for this article.
December 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28502826/recurrent-ovarian-sertoli-leydig-cell-tumor-a-rare-cause-of-secondary-amenorrhea-in-adolescence
#7
Amy M Luke, John W Moroney, Andrea Snitchler, Susan L Whiteway
BACKGROUND: Ovarian tumors, although uncommon in children, can retain endocrine function that disrupts normal feedback mechanisms leading to amenorrhea. Inheritance of germline DICER1 mutations can lead to increased risk for development of ovarian Sertoli-Leydig cell tumors (SLCT). CASE: We report the first case of secondary amenorrhea due to elevated inhibin B levels in an adolescent female with an ovarian SLCT. SUMMARY AND CONCLUSIONS: Ovarian tumors should be included in the differential diagnosis for pediatric patients presenting with menstrual irregularities...
May 11, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28475292/long-term-follow-up-of-endocrine-function-among-young-children-with-newly-diagnosed-malignant-central-nervous-system-tumors-treated-with-irradiation-avoiding-regimens
#8
Anne M Cochrane, Clement Cheung, Kasey Rangan, David Freyer, Leena Nahata, Girish Dhall, Jonathan L Finlay
BACKGROUND: The adverse effects of irradiation on endocrine function among patients with pediatric brain tumor are well documented. Intensive induction chemotherapy followed by marrow-ablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) without central nervous system (CNS) irradiation has demonstrated efficacy in a proportion of very young children with some malignant CNS tumors. This study assessed the long-term endocrine function of young children following chemotherapy-only treatment regimens...
May 5, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28471115/clinical-characteristics-and-treatment-of-thyroid-cancer-in-children-and-adolescents-a-retrospective-analysis-of-83-patients
#9
Xiao-Chun Mao, Wen-Qiao Yu, Jin-Biao Shang, Ke-Jing Wang
OBJECTIVE: To study the clinical characteristics, treatment, and prognosis of thyroid cancer in children and adolescents. METHODS: We performed a retrospective analysis of clinical data from 83 cases of thyroid cancer in children and adolescents from January 1990 to December 2010. We compared extra-thyroid extension, lymph node metastasis, distant metastasis, and prognosis between pediatric patients ≤12 years of age (27 cases) and those >12 years of age (56 cases)...
May 2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28450850/cholecystokinin-from-local-gut-hormone-to-ubiquitous-messenger
#10
REVIEW
Jens F Rehfeld
Cholecystokinin (CCK) was discovered in 1928 in jejunal extracts as a gallbladder contraction factor. It was later shown to be member of a peptide family, which are all ligands for the CCK1 and CCK2 receptors. CCK peptides are known to be synthetized in small intestinal endocrine I-cells and cerebral neurons. But in addition, CCK is expressed in several endocrine glands (pituitary cells, thyroid C-cells, pancreatic islets, the adrenals, and the testes); in peripheral nerves; in cortical and medullary kidney cells; in cardial myocytes; and in cells of the immune system...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28428677/hypothyroidism-in-pediatric-population-bosnian-and-herzegovinian-situation
#11
Edo Hasanbegovic, Snijezana Hasanbegovic, Edin Begic
INTRODUCTION: Thyroid gland diseases in children are in second place by frequency among all endocrine disorders. When interpreting the results of the thyroid function assessment it should be taken into account the significant differences in the concentrations of TSH, thyroid hormones, thyroid binding proteins and calcitonin among children of different ages. GOAL: To present the age and sex structure of the patients diagnosed with hypothyroidism, evaluate diagnostic methods for making diagnosis, evaluation of etiology of hypothyroidism, with special review of the therapeutic modality...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28402984/contribution-of-hormonal-cytology-in-girls-and-adolescents-to-reproductive-health-a-traditional-technique-monitoring-recent-problems
#12
Jaroslava Dušková, Barbara Goldová, Lenka Matiášková, Alena Beková, Jana Skřenková
OBJECTIVE: To study the contribution of hormonal cytology in contemporary disturbances of fertility. DESIGN: Over a 10-year period (2006-2015), 6,688 vaginal fornix cytologies of 2,350 patients were investigated. For a more detailed analysis, a 3-year period from 2013 to 2015 was chosen. Four hundred and fifty-two patients were investigated, many of them several times and for a period longer than the 3 years analyzed. RESULTS: The main disorders examined and treated via a gentle hormonal medication support and life style corrections by a pediatric gynecologist were: pubertas praecox - thelarche praecox and early menarche; dysfunctional juvenile metrorrhagia; central and peripheral endocrine disorders; eating disorders - anorexia mentalis and bulimia; obesity; excessive sport activities; autoimmune disorders, and others...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28397413/endocrine-and-metabolic-consequences-due-to-restrictive-carbohydrate-diets-in-children-with-type-1-diabetes-an-illustrative-case-series
#13
Martin de Bock, Kristine Lobley, Donald Anderson, Elizabeth Davis, Kim Donaghue, Marcelle Pappas, Aris Siafarikas, Yoon Hi Cho, Timothy Jones, Carmel Smart
Low carbohydrate diets for the management of type 1 diabetes have been popularised by social media. The promotion of a low carbohydrate diet in lay media is in contrast to published pediatric diabetes guidelines that endorse a balanced diet from a variety of foods for optimal growth and development in children with type 1 diabetes. This can be a source of conflict in clinical practice. We describe a series of 6 cases where adoption of a low carbohydrate diet in children impacted growth and cardiovascular risk factors with potential long-term sequelae...
April 11, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28393785/modifying-risks-to-improve-outcome-in-cardiac-surgery-an-anesthesiologist-s-perspective
#14
REVIEW
Murali Chakravarthy
Challenging times are here for cardiac surgical and anesthesia team. The interventional cardiologist seem to have closed the flow of 'good cases' coming up for any of the surgery,; successful percutaneous interventions seem to be offering reasonable results in these patients, who therefore do not knock on the doors of the surgeons any more . It is a common experience among the cardiac anesthesiologists and surgeons that the type of the cases that come by now are high risk. That may be presence of comorbidities, ongoing medical therapies, unstable angina, uncontrolled heart failure and rhythm disturbances; and in patients with ischemic heart disease, the target coronaries are far from ideal...
April 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28391043/the-effect-of-vpa-on-bone-from-clinical-studies-to-cell-cultures-the-molecular-mechanisms-revisited
#15
REVIEW
Dimitris A Pitetzis, Martha G Spilioti, John G Yovos, Maria P Yavropoulou
PURPOSE: Valproic acid (VPA) is a broad-spectrum antiepileptic drug, which is widely used as a first line treatment for idiopathic and symptomatic generalized epilepsy, as well as in non-epileptic psychiatric disorders in adult and pediatric patients. Although valproic acid is considered to be a generally well-tolerated drug, numerous studies have shown an increased bone loss and fracture risk in patients treated with VPA. The purpose of this review is to outline recent findings on VPA molecular mechanisms and their action on bone metabolism...
March 22, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28381452/management-of-endocrine-disease-arguments-for-the-prolonged-use-of-antithyroid-drugs-in-children-with-graves-disease
#16
Juliane Leger, Jean-Claude Carel
Graves' disease is an autoimmune disorder. It is the major cause of hyperthyroidism but is rare in children. Patients are initially managed with antithyroid drugs (ATD), in the form of methimazole/carbimazole. A major disadvantage of ATD treatment is the high risk of relapse, exceeding 70% of children treated for a duration of two years, and the potential major side effects of the drug reported in exceptional cases. The major advantage of ATD treatment is that normal homeostasis of the hypothalamus-pituitary thyroid axis may be restored, with periods of drug treatment followed by freedom from medical intervention achieved in about 40 to 50% of cases after prolonged ATD treatment for several years in recent studies...
April 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28374818/autoimmune-pancreatitis-in-children-characteristic-features-diagnosis-and-management
#17
Isabelle Scheers, Joseph J Palermo, Steven Freedman, Michael Wilschanski, Uzma Shah, Maisam Abu-El-Haija, Bradley Barth, Douglas S Fishman, Cheryl Gariepy, Matthew J Giefer, Melvin B Heyman, Ryan W Himes, Sohail Z Husain, Tom K Lin, Quin Liu, Mark Lowe, Maria Mascarenhas, Veronique Morinville, Chee Y Ooi, Emily R Perito, David A Piccoli, John F Pohl, Sarah J Schwarzenberg, David Troendle, Steven Werlin, Bridget Zimmerman, Aliye Uc, Tanja Gonska
OBJECTIVES: Autoimmune pancreatitis (AIP) is an increasingly recognized disease entity, but data in children are limited. AIP presentation and outcome in children might differ from the adult experience. We aim to determine the characteristic features of AIP in children. METHODS: Data about clinical symptoms, imaging, histology, and treatment were collected using two sources: (i) a systematic literature search and (ii) the INSPPIRE database, the largest international multicenter study of pancreatitis in children and the Cliniques Universitaires St-Luc (CUSL) registry...
April 4, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28368518/functional-hypothalamic-amenorrhea-an-endocrine-society-clinical-practice-guideline
#18
Catherine M Gordon, Kathryn E Ackerman, Sarah L Berga, Jay R Kaplan, George Mastorakos, Madhusmita Misra, M Hassan Murad, Nanette F Santoro, Michelle P Warren
Cosponsoring Associations: The American Society for Reproductive Medicine, the European Society of Endocrinology, and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. Objective: To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA). Participants: The participants include an Endocrine Society-appointed task force of eight experts, a methodologist, and a medical writer...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28364046/neonatal-hypoglycemia
#19
Alecia Thompson-Branch, Thomas Havranek
Lower blood glucose values are common in the healthy neonate immediately after birth as compared to older infants, children, and adults. These transiently lower glucose values improve and reach normal ranges within hours after birth. Such transitional hypoglycemia is common in the healthy newborn. A minority of neonates experience a more prolonged and severe hypoglycemia, usually associated with specific risk factors and possibly a congenital hypoglycemia syndrome. Despite the lack of a specific blood glucose value that defines hypoglycemia, concern for substantial neurologic morbidity in the neonatal population has led to the generation of guidelines by both the American Academy of Pediatrics (AAP) and the Pediatric Endocrine Society (PES)...
April 2017: Pediatrics in Review
https://www.readbyqxmd.com/read/28359099/pediatric-obesity-assessment-treatment-and-prevention-an-endocrine-society-clinical-practice-guideline
#20
Dennis M Styne, Silva A Arslanian, Ellen L Connor, Ismaa Sadaf Farooqi, M Hassan Murad, Janet H Silverstein, Jack A Yanovski
Cosponsoring Associations: The European Society of Endocrinology and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. Objective: To formulate clinical practice guidelines for the assessment, treatment, and prevention of pediatric obesity. Participants: The participants include an Endocrine Society-appointed Task Force of 6 experts, a methodologist, and a medical writer. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
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