Dilys D Weijers, Steffen Hirsch, Jette J Bakhuizen, Nienke van Engelen, Lennart A Kester, Mariëtte E G Kranendonk, Laura S Hiemcke-Jiwa, Evelien de Vos-Kerkhof, Jan L C Loeffen, Robert J Autry, Kristian W Pajtler, Natalie Jäger, Marjolijn C J Jongmans, Roland P Kuiper
Lynch syndrome (LS) predisposes to cancer in adulthood and is caused by heterozygous germline variants in a mismatch repair (MMR) gene. Recent studies show an increased prevalence of LS among children with cancer, suggesting a causal relationship. For LS-spectrum (LSS) cancers, including high-grade gliomas and colorectal cancer, causality has been supported by typical MMR-related tumor characteristics, but for non-LSS cancers, causality is unclear. We characterized 20 malignant tumors of 18 children with LS, including 16 non-LSS tumors...
January 4, 2024: International Journal of Cancer. Journal International du Cancer