keyword
MENU ▼
Read by QxMD icon Read
search

Kasai

keyword
https://www.readbyqxmd.com/read/28634674/prognostic-impact-of-nutritional-status-assessed-by-the-controlling-nutritional-status-score-in-patients-with-stable-coronary-artery-disease-undergoing-percutaneous-coronary-intervention
#1
Hideki Wada, Tomotaka Dohi, Katsumi Miyauchi, Shinichiro Doi, Hirokazu Konishi, Ryo Naito, Shuta Tsuboi, Manabu Ogita, Takatoshi Kasai, Shinya Okazaki, Kikuo Isoda, Satoru Suwa, Hiroyuki Daida
BACKGROUND: Recently, malnutrition has been shown to be related to worse clinical outcomes in patients with heart failure. However, the association between nutritional status and clinical outcomes in patients with coronary artery disease (CAD) remains unclear. We investigated the prognostic value of malnutrition assessed by the Controlling Nutritional Status (CONUT; range 0-12, higher = worse, consisting of serum albumin, cholesterol and lymphocytes) score in patients with CAD. METHODS: The CONUT score was measured on admission in a total of 1987 patients with stable CAD who underwent elective percutaneous coronary intervention (PCI) between 2000 and 2011...
June 20, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28625998/structures-compositions-and-activities-of-live-shewanella-biofilms-formed-on-graphite-electrodes-in-electrochemical-flow-cells
#2
Miho Kitayama, Ryota Koga, Takuya Kasai, Atsushi Kouzuma, Kazuya Watanabe
An electrochemical flow cell equipped with a graphite working electrode (WE) at the bottom was inoculated with Shewanella oneidensis MR-1 expressing an anaerobic fluorescence protein, and biofilm formation on WE were observed over time during current generation at WE potentials of +0.4 and 0 V (vs. standard hydrogen electrodes) under electrolyte-flow conditions. Electrochemical analyses suggest the presence of unique electron-transfer mechanisms in the +0.4 V biofilm. Microscopic analyses revealed that, different from aerobic biofilms, current-generating biofilm (at +0...
June 16, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28622905/discovery-of-novel-somatostatin-receptor-subtype-5-sstr5-antagonists-pharmacological-studies-and-design-to-improve-pharmacokinetic-profiles-and-human-ether-a-go-go-related-gene-herg-inhibition
#3
Takeshi Yamasaki, Hideki Hirose, Tohru Yamashita, Nobuyuki Takakura, Sachie Morimoto, Takashi Nakahata, Asato Kina, Yoshihide Nakano, Yumiko Okano Tamura, Jun Sugama, Tomoyuki Odani, Yuji Shimizu, Shinji Iwasaki, Masanori Watanabe, Tsuyoshi Maekawa, Shizuo Kasai
Somatostatin (SST) is a peptide hormone comprising 14 or 28 amino acids that inhibits endocrine and exocrine secretion via five distinct G-protein-coupled receptors (SSTR1-5). SSTR5 has an important role in inhibiting the secretion of pancreatic and gastrointestinal hormones (e.g., insulin, GLP-1, PYY) through the binding of SSTs; hence, SSTR5 antagonists are expected to be novel anti-diabetic drugs. In the course of our lead generation program of SSTR5 antagonists, we have discovered a novel spiroazetidine derivative 3a...
June 13, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28620753/population-pharmacokinetics-of-cyclosporine-a-in-japanese-renal-transplant-patients-comprehensive-analysis-in-a-single-center
#4
Akira Okada, Hidetaka Ushigome, Misaki Kanamori, Aya Morikochi, Hidefumi Kasai, Tadashi Kosaka, Takatoshi Kokuhu, Asako Nishimura, Nobuhito Shibata, Keizo Fukushima, Norio Yoshimura, Nobuyuki Sugioka
PURPOSE: Cyclosporine A (CyA), a potent immunosuppressive agent used in renal transplantation, has a narrow therapeutic window and a large variability in blood concentrations. This study aimed to develop a population pharmacokinetic (PPK) model of CyA in living-donor renal transplant patients at a single center and identify factors influencing CyA pharmacokinetics (PK). METHODS: A total of 660 points (preoperative) and 4785 points (postoperative) of blood concentration data from 98 patients who underwent renal transplantation were used...
June 15, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28616952/room-temperature-discrete-charge-fluctuation-dynamics-of-a-single-molecule-adsorbed-on-a-carbon-nanotube
#5
Agung Setiadi, Hayato Fujii, Seiya Kasai, Ken-Ichi Yamashita, Takuji Ogawa, Takashi Ikuta, Yasushi Kanai, Kazuhiko Matsumoto, Yuji Kuwahara, Megumi Akai-Kasaya
Detection and use of physical noise fluctuations in a signal provides significant advantages in the development of bio- and neuro-sensing and functional mimicking devices. Low-dimensional carbon nanomaterials are a good candidate for use in noise generation due to the high surface sensitivity of these materials, which may themselves serve as the main building blocks of these devices. Here, we demonstrate that the addition of a molecule with high redox activity to a carbon nanotube (CNT) field-effect transistor provides tunable current fluctuation noise...
June 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28611846/safety-of-allogeneic-canine-adipose-tissue-derived-mesenchymal-stem-cell-intraspinal-transplantation-in-dogs-with-chronic-spinal-cord-injury
#6
Cláudia Cardoso Maciel Escalhão, Isalira Peroba Ramos, Camila Hochman-Mendez, Tais Hanae Kasai Brunswick, Sergio Augusto Lopes Souza, Bianca Gutfilen, Regina Coeli Dos Santos Goldenberg, Tatiana Coelho-Sampaio
This is a pilot clinical study primarily designed to assess the feasibility and safety of X-ray-guided percutaneous intraspinal injection of allogeneic canine adipose tissue-derived mesenchymal stem cells in dogs with chronic spinal cord injury. Six dogs with chronic paraplegia (≥six months) were intraparenchymally injected with allogeneic cells in the site of lesion. Cells were obtained from subcutaneous adipose tissue of a healthy dog, cultured to passage 3, labeled with (99m)Technetium, and transplanted into the lesion by percutaneous X-ray-guided injection...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28608572/identification-of-candidate-genes-involved-in-the-etiology-of-sporadic-tourette-syndrome-by-exome-sequencing
#7
Yosuke Eriguchi, Hitoshi Kuwabara, Aya Inai, Yuki Kawakubo, Fumichika Nishimura, Chihiro Kakiuchi, Mamoru Tochigi, Jun Ohashi, Naoto Aoki, Kayoko Kato, Hiroyuki Ishiura, Jun Mitsui, Shoji Tsuji, Koichiro Doi, Jun Yoshimura, Shinichi Morishita, Takafumi Shimada, Masaomi Furukawa, Tadashi Umekage, Tsukasa Sasaki, Kiyoto Kasai, Yukiko Kano
Tourette Syndrome (TS) is a neurodevelopmental disorder characterized by chronic motor and vocal tics. Although there is a large genetic contribution, the genetic architecture of TS remains unclear. Exome sequencing has successfully revealed the contribution of de novo mutations in sporadic cases with neuropsychiatric disorders such as autism and schizophrenia. Here, using exome sequencing, we investigated de novo mutations in individuals with sporadic TS to identify novel risk loci and elucidate the genetic background of TS...
June 13, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28604280/express-the-anticoagulant-effects-of-warfarin-and-the-bleeding-risk-associated-with-its-use-in-patients-with-chronic-thromboembolic-pulmonary-hypertension-at-a-specialist-center-in-japan-a-retrospective-cohort-study
#8
Takayuki Sanada Jujo, Nobuhiro Tanabe, Seiichiro Sakao, Toshihiko Sugiura, Ayumi Sekine, Rintaro Nishimura, Rika Suda, Akira Naito, Hideki Miwa, Keiko Yamamoto, Akane Sasaki, Akane Matsumura, Ryogo Ema, Hajime Kasai, Fumiaki Kato, Koichiro Tatsumi
No abstract text is available yet for this article.
January 1, 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28598477/revealing-the-slow-decomposition-kinetics-of-type-i-clathrate-ba8ga16ge30
#9
Hazel Reardon, Anders B Blichfeld, Hidetaka Kasai, Hao Yin, Espen Drath Bøjesen, Bo B Iversen
Inconsistencies in high temperature thermoelectric property measurements of Ba8Ga16Ge30 have prompted our study on the thermal stability of this heavily studied inorganic clathrate. Using X-ray diffraction, thermal analysis, and imaging techniques on both powder and spark plasma sintered pelletized samples, we probe the structure and decomposition characteristics of this important high temperature thermoelectric material. We demonstrate that the decomposition of Ba8Ga16Ge30 is extremely dependent on the heating conditions employed and, as a result of the slow decomposition kinetics of the clathrate, reveal that the true stability of this system has been overlooked in the extensive literature available...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28594581/learning-curve-analysis-of-laparoscopic-kasai-portoenterostomy
#10
Zhihan Li, Yongqin Ye, Zhouguang Wu, Bin Wang
OBJECTIVE: To compare the surgical outcomes of Kasai Portoenterostomy (PE) and investigate the learning curve of laparoscopic Kasai Portoenterostomy (Lap-PE). MATERIALS AND METHODS: Retrospective chart review of 80 cases of biliary atresia (type III) undergoing Lap-PE at Shenzhen Children's Hospital from January 2011 to June 2015, all of which were performed by the same surgical team. According to the operative sequences, the cases were equally divided into four phases (Phase I, II, III, and IV), which contain 20 cases in each...
June 8, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28590589/living-donor-liver-transplantation-for-post-kasai-biliary-atresia-analysis-of-pretransplant-predictors-of-outcomes-in-infants
#11
Toshihiro Kitajima, Seisuke Sakamoto, Kengo Sasaki, Hajime Uchida, Soichi Narumoto, Akinari Fukuda, Satoshi Teramukai, Shinji Uemoto, Mureo Kasahara
After decades of dramatic surgical innovations in pediatric living donor liver transplantation (LDLT), LDLT for biliary atresia (BA) still poses various challenges. This study reviewed our experience with LDLT for children with post-Kasai BA and evaluated outcomes and prognostic factors. From 2005 to 2016, 168 post-Kasai BA LDLT patients were enrolled and divided into three groups by age. Patient characteristics and perioperative data were compared. Predictors of morbidity and mortality following LDLT were analyzed in 93 infants...
June 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28588613/preoperative-serum-il-12p40-is-a-potential-predictor-of-kasai-portoenterostomy-outcome-in-infants-with-biliary-atresia
#12
Shaimaa Samy Goda, Mohamed Ahmed Khedr, Soha Zaki Elshenawy, Tarek Mohamed Ibrahim, Hanaa Ahmed El-Araby, Mostafa Mohamed Sira
The standard-of-care treatment for biliary atresia (BA) is surgical restoration of bile flow by Kasai portoenterostomy. We aimed to study serum interleukin- (IL-) 12p40, a natural antagonist for the proinflammatory IL-12p70, and its relation to surgical outcomes of BA. The study included 75 infants with neonatal cholestasis: BA group (n = 25), non-BA cholestasis group (n = 30), and neglected BA group (n = 20), in addition to thirty healthy neonates serving as controls. IL-12p40 was measured by ELISA in all individuals and a second assessment was performed 3 months postoperatively in the BA group...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28586143/current-status-of-non-invasive-prenatal-testing-in-japan
#13
Osamu Samura, Akihiko Sekizawa, Nobuhiro Suzumori, Aiko Sasaki, Seiji Wada, Haruka Hamanoue, Fumiki Hirahara, Hideaki Sawai, Hiroaki Nakamura, Takahiro Yamada, Kiyonori Miura, Hideaki Masuzaki, Setsuko Nakayama, Takashi Okai, Yoshimasa Kamei, Akira Namba, Jun Murotsuki, Tomohiro Tanemoto, Akimune Fukushima, Kazufumi Haino, Shinya Tairaku, Keiichi Matsubara, Kazuhisa Maeda, Takashi Kaji, Masanobu Ogawa, Hisao Osada, Haruki Nishizawa, Yoko Okamoto, Takeshi Kanagawa, Aiko Kakigano, Michihiro Kitagawa, Masaki Ogawa, Shunichiro Izumi, Yukiko Katagiri, Naoki Takeshita, Yasuyo Kasai, Katsuhiko Naruse, Reiko Neki, Hisashi Masuyama, Maki Hyodo, Yukie Kawano, Takashi Ohba, Kiyotake Ichizuka, Yasuhiro Kido, Toshiyuki Fukao, Norio Miharu, Takeshi Nagamatsu, Atsushi Watanabe, Naoki Hamajima, Masaya Hirose, Ayako Sanui, Nahoko Shirato, Junko Yotsumoto, Miyuki Nishiyama, Tatsuko Hirose, Haruhiko Sago
AIM: The purpose of this study was to report the 3-year experience of a nationwide demonstration project to introduce non-invasive prenatal testing (NIPT) of maternal plasma for aneuploidy, and review the current status of NIPT in Japan. METHODS: Tests were conducted to detect aneuploidy in high-risk pregnant women, and adequate genetic counseling was provided. The clinical data, test results, and pregnancy outcomes were recorded. We discuss the problems of NIPT on the basis of published reports and meta-analyses...
June 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28585693/influences-of-soaking-temperature-and-storage-conditions-on-hardening-of-soybeans-glycine-max-and-red-kidney-beans-phaseolus-vulgaris
#14
Takako Koriyama, Yoko Sato, Kumiko Iijima, Midori Kasai
The influences of soaking treatment and storage conditions on the softening of cooked beans, namely, soybeans and red kidney beans, were investigated. It was revealed that the softening of fresh soybeans and fresh red kidney beans was suppressed during subsequent boiling after soaking treatment at 50 and 60 °C. Furthermore, in treated aged soybeans and red kidney beans that were subjected to storage at 30 °C/75% relative humidity for 6 mo and soaking treatment at 50 to 60 °C, the hardness during cooking was further amplified...
June 6, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28577363/international-workshop-on-insecticide-resistance-in-vectors-of-arboviruses-december-2016-rio-de-janeiro-brazil
#15
Vincent Corbel, Dina M Fonseca, David Weetman, João Pinto, Nicole L Achee, Fabrice Chandre, Mamadou B Coulibaly, Isabelle Dusfour, John Grieco, Waraporn Juntarajumnong, Audrey Lenhart, Ademir J Martins, Catherine Moyes, Lee Ching Ng, Kamaraju Raghavendra, Hassan Vatandoost, John Vontas, Pie Muller, Shinji Kasai, Florence Fouque, Raman Velayudhan, Claire Durot, Jean-Philippe David
Vector-borne diseases transmitted by insect vectors such as mosquitoes occur in over 100 countries and affect almost half of the world's population. Dengue is currently the most prevalent arboviral disease but chikungunya, Zika and yellow fever show increasing prevalence and severity. Vector control, mainly by the use of insecticides, play a key role in disease prevention but the use of the same chemicals for more than 40 years, together with the dissemination of mosquitoes by trade and environmental changes, resulted in the global spread of insecticide resistance...
June 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28575995/improvement-of-adhesion-and-proliferation-of-mouse-embryonic-stem-cells-cultured-on-ozone-uv-surface-modified-substrates
#16
Kohei Kasai, Yuka Kimura, Shogo Miyata
Culturing pluripotent stem cells effectively requires feeder cell layers or cell adhesion matrix coating. However, the feeder cell layers or animal-derived factors have to be removed to apply the pluripotent stem cells as resources for regenerative medicine. To enable xeno-free culture conditions, we focused on the UV/ozone surface treatment technique for polystyrene cell culture substrates to improve the adhesion and proliferation of pluripotent stem cells. In this study, as a fundamental research for the feeder- and matrix coating-free culture system for embryonic stem cells (ESCs), mouse ESCs were cultured on UV/ozone-modified polystyrene substrates without feeder layers...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28573490/interactive-association-of-serum-uric-acid-and-total-bilirubin-with-renal-dysfunction-among-community-dwelling-subjects
#17
Ryuichi Kawamoto, Daisuke Ninomiya, Kensuke Senzaki, Yoshihisa Kasai, Tomo Kusunoki, Nobuyuki Ohtsuka, Teru Kumagi
PURPOSE: Chronic kidney disease is a major public health concern. Serum uric acid (SUA) at high levels was oxidative stress agents, and total bilirubin (T-BiL) at mildly increased levels was potent antioxidants, but whether SUA and T-BiL produce an additive interaction for the risk of renal dysfunction remains unclear. METHODS: The subjects comprised 567 men aged 71 ± 8 (mean ± standard deviation) years and 853 women aged 70 ± 8 years from a rural village...
June 1, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28569787/inflammatory-mediator-ultra-low-molecular-weight-hyaluronan-triggers-necrosis-of-b-precursor-leukemia-cells-with-high-surface-cd44-expression
#18
Shin Kasai, Yoshiyuki Furuichi, Norie Ando, Keiko Kagami, Masako Abe, Takaya Nakane, Kumiko Goi, Takeshi Inukai, Sei Saitoh, Shinichi Ohno, Shogo Okazaki, Osamu Nagano, Hideyuki Saya, Kanji Sugita
Acute lymphoblastic leukemia (ALL) with mixed lineage leukemia (MLL) gene rearrangements (MLL+ALL) has a dismal prognosis and is characterized by high surface CD44 expression. Known that CD44 has the specific binding sites for a natural ligand hyaluronan (HA), we investigated biological effects of HA with different molecular sizes on MLL+ALL cell lines, and found that the addition of ultra-low-molecular-weight (ULMW)-HA strongly suppressed their thymidine uptakes. The MLL+ALL cell line lacking surface CD44 expression established by genome editing showed no suppression of thymidine uptake...
June 1, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28566606/pulmonary-endometriosis-which-probably-occurred-through-hematogenous-metastasis-after-artificial-abortion
#19
Kazushi Fujimoto, Hajime Kasai, Masaki Suga, Toshihiko Sugiura, Jiro Terada, Hidemi Suzuki, Masayuki Oota, Ichiro Yoshino, Yukio Nakatani, Koichiro Tatsumi
Pulmonary endometriosis (PEM) is a rare disease characterized by the proliferation of ectopic endometrial tissue in the lungs, which presents as catamenial hemoptysis. A 20-year-old-woman was admitted for repeated hemoptysis. Chest CT revealed a ground-glass opacity that appeared consistently with her menstrual cycle. Our detailed inquiry revealed a history of artificial abortion, which was followed by the use of oral contraceptives and catamenial hemoptysis after the discontinuation of these medications. Surgical removal was performed and histopathological examinations confirmed PEM...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28565767/hair-follicle-derived-mesenchymal-cells-support-undifferentiated-growth-of-embryonic-stem-cells
#20
Vanessa Carvalho Coelho de Oliveira, Danúbia Silva Dos Santos, Leandro Vairo, Tais Hanae Kasai Brunswick, Luiz Alberto Soares Pimentel, Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho, Regina Coeli Dos Santos Goldenberg
The aim of the present study was to investigate whether feeder layers composed of human hair follicle-derived mesenchymal stem cells (hHFDCs) are able to support human embryonic stem cells (hESCs). hHFDCs and mouse embryonic fibroblasts (MEFs) were isolated and cultured in Dulbecco's modified Eagle's medium (DMEM)/F-12 and low-glucose DMEM, respectively. hHFDCs were passaged three times and subsequently characterized. hHFDCs and MEFs were mitotically inactivated with mitomycin C for 3 h prior to co-culture with H9-hESCs...
May 2017: Experimental and Therapeutic Medicine
keyword
keyword
102140
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"