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https://www.readbyqxmd.com/read/28934267/patient-derived-osteosarcoma-cells-are-resistant-to-methotrexate
#1
Amanda Dos Santos Cavalcanti, Walter Meohas, Gabriele de Oliveira Ribeiro, Ana Cristina de Sá Lopes, Sharareh Gholamin, Mostafa Razavi, Taís Hanae Kasai Brunswick, Amir Avan, João Antonio Matheus Guimarães, Maria Eugenia Leite Duarte, Suzana Assad Kahn
Osteosarcoma is the most common primary bone tumor in children and young adults. The median survival of osteosarcoma patients has not significantly improved since 1990, despite administration of different classes of chemotherapy agents, such as methotrexate, cisplatin and doxorubicin. Cancer stem cells (CSCs) are responsible for the resistance of osteosarcoma to chemotherapy and OCT4, SOX2 and SSEA4 have been used to identify CSCs in osteosarcoma. Here, we used low-passage patient-derived osteosarcoma cells and osteosarcoma cells directly isolated from patients before and after chemotherapy treatments to evaluate the effects of chemotherapy on stem cell markers expression...
2017: PloS One
https://www.readbyqxmd.com/read/28932518/do-the-blood-pressure-changes-in-association-with-continuous-positive-airway-pressure-compliance-play-an-important-role-to-improve-cardiovascular-outcomes
#2
EDITORIAL
Azusa Murata, Takatoshi Kasai
No abstract text is available yet for this article.
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28927907/extra-gastrointestinal-anisakidosis-caused-by-pseudoterranova-azarasi-manifesting-as-strangulated-inguinal-hernia
#3
Akari Mitsuboshi, Hiroshi Yamaguchi, Yusuke Ito, Tetsushi Mizuno, Masaharu Tokoro, Masashi Kasai
The incidence of anisakidosis continues to increase worldwide due to increased consumption of undercooked fish. Although anisakidosis can be categorized into four clinical phenotypes (gastric, intestinal, ectopic, and allergic), ectopic forms of the condition are much less common than gastric or intestinal forms when caused by Pseudoterranova spp. We report the case of a 5-year-old patient who presented with a rapidly growing left inguinal mass and was subsequently diagnosed with extra-gastrointestinal anisakidosis caused by Pseudoterranova azarasi...
September 16, 2017: Parasitology International
https://www.readbyqxmd.com/read/28927787/a-mimetic-of-the-msin3-binding-helix-of-nrsf-rest-ameliorates-abnormal-pain-behavior-in-chronic-pain-models
#4
Hiroshi Ueda, Jun-Ichi Kurita, Hiroyuki Neyama, Yuuka Hirao, Hiroyuki Kouji, Tadashi Mishina, Masaji Kasai, Hirofumi Nakano, Atsushi Yoshimori, Yoshifumi Nishimura
The neuron-restrictive silencing factor NRSF/REST binds to neuron-restrictive silencing elements in neuronal genes and recruits corepressors such as mSin3 to inhibit epigenetically neuronal gene expression. Because dysregulation of NRSF/REST is related to neuropathic pain, here, we have designed compounds to target neuropathic pain based on the mSin3-binding helix structure of NRSF/REST and examined their ability to bind to mSin3 by NMR. One compound, mS-11, binds strongly to mSin3 with a binding mode similar to that of NRSF/REST...
September 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28925587/lessons-learned-from-the-development-and-parameterization-of-a-computer-simulation-model-to-evaluate-task-modification-for-healthcare-providers
#5
Parastu Kasaie, W David Kelton, Rachel M Ancona, Michael J Ward, Craig M Froehle, Michael S Lyons
Computer simulation is a highly advantageous method for understanding and improving healthcare operations with a wide variety of possible applications. Most computer-simulation studies in emergency medicine have sought to improve allocation of resources to meet demand, or to assess the impact of hospital and other system policies on emergency department (ED) throughput. These models have enabled essential discoveries that can be used to improve the general structure and functioning of EDs. Theoretically, computer simulation could also be used to examine the impact of adding or modifying specific provider tasks...
September 19, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28919111/promethazine-hydrochloride-inhibits-ectopic-fat-cell-formation-in-skeletal-muscle
#6
Takehiro Kasai, Masashi Nakatani, Naoki Ishiguro, Kinji Ohno, Naoki Yamamoto, Mitsuhiro Morita, Harumoto Yamada, Kunihiro Tsuchida, Akiyoshi Uezumi
Fatty degeneration of skeletal muscle leads to muscle weakness and loss of function. Preventing fatty degeneration in skeletal muscle is important, but no drug has been used clinically. In this study, we performed drug repositioning using human platelet-derived growth factor receptor α (PDGFRα)-positive mesenchymal progenitors that have been proved to be an origin of ectopic adipocytes in skeletal muscle. We found that promethazine hydrochloride (PH) inhibits adipogenesis in a dose-dependent manner without cell toxicity...
September 14, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28917156/tgf%C3%AE-1-synergizes-with-flt3-ligand-to-induce-chemoresistant-quiescence-in-acute-lymphoblastic-leukemia-with-mll-gene-rearrangements
#7
M Tamai, Y Furuichi, S Kasai, N Ando, D Harama, K Goi, T Inukai, K Kagami, M Abe, H Ichikawa, K Sugita
Fms-like tyrosine kinase 3 (FLT3) is highly expressed in mixed-lineage leukemia (MLL) gene-rearranged acute lymphoblastic leukemia (MLL+ALL) with a dismal prognosis. We previously reported that FLT3 ligand (FL) stimulation induced cell cycle arrest in MLL+ALL cells leading to resistance against anti-leukemic agents. Given that FL stimulation enhanced transforming growth factor (TGF)β1 mRNA levels in MLL+ALL cells, we extensively examined the effect of TGFβ1 on the cell cycle progression and chemosensitivity in MLL+ALL cells, and found that TGFβ1 stimulation induced MLL+ALL cells into cell cycle arrest resistant to arabinosyl cytosine; its effect was markedly enhanced in synergy with FL...
September 13, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28915895/impact-of-ugt1a1-gene-polymorphisms-on-plasma-dolutegravir-trough-concentrations-and-neuropsychiatric-adverse-events-in-japanese-individuals-infected-with-hiv-1
#8
Hiroki Yagura, Dai Watanabe, Hiroyuki Kushida, Kosuke Tomishima, Hiroaki Togami, Atsushi Hirano, Masaaki Takahashi, Kazuyuki Hirota, Motoko Ikuma, Daisuke Kasai, Yasuharu Nishida, Munehiro Yoshino, Kunio Yamazaki, Tomoko Uehira, Takuma Shirasaka
BACKGROUND: Dolutegravir (DTG) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1), and partly by cytochrome P450 3A (CYP3A). Therefore, we focused on UGT1A1 gene polymorphisms (*6 and *28) in Japanese individuals infected with human immunodeficiency virus (HIV)-1 to examine the relationship between their plasma trough concentration of DTG and gene polymorphisms. Recently, neuropsychiatric adverse events (NP-AEs) after the use of DTG have become a concern, so the association between UGT1A1 gene polymorphisms and selected NP-AEs was also investigated...
September 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28914743/effectiveness-of-bone-suppression-imaging-in-the-detection-of-lung-nodules-on-chest-radiographs-relevance-to-anatomic-location-and-observer-s-experience
#9
Tomohiro Miyoshi, Junji Yoshida, Nao Aramaki, Yuki Matsumura, Keiju Aokage, Tomoyuki Hishida, Tsuyoshi Kobayashi, Shinichi Tsubura, Shinsuke Katsuhara, Satoshi Kasai, Yasuhiko Sasano, Kanji Nagai, Masahiro Tsuboi
OBJECTIVE: To evaluate the effectiveness of bone suppression imaging (BSI) software in lung-nodule detection on chest radiographs (CXRs) in relation to nodule location and observer's experience. MATERIALS AND METHODS: The CXRs of 80 patients, of which 40 had a lung nodule (8 to 30 mm in diameter) and 40 did not have any nodules, were interpreted by 20 observers comprising of 7 pulmonologists with >10 years of experience and 13 pulmonology residents. Each patient's image was sequentially read, first using the standard CXR and thereafter with the BSI software...
September 13, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28903616/circulating-dehydroepiandrosterone-sulphate-decreases-even-with-a-slight-change-in-oestradiol
#10
Sumika Matsui, Toshiyuki Yasui, Kana Kasai, Kanako Yoshida, Takeshi Kato, Hirokazu Uemura, Akira Kuwahara, Toshiya Matsuzaki, Minoru Irahara
The aim of this study was to determine the effect of hormone replacement therapy (HRT) on changes in circulating dehydroepiandrosterone-sulphate (DHEA-S) with focus on the relationship between oestrogen level and change in DHEA-S. Forty-two women were enrolled in this longitudinal study. Nineteen women received oral oestradiol and twenty-three women received transdermal oestradiol continuously. Twenty women received progesterone continuously except for women who had undergone hysterectomy. Circulating oestradiol, follicle-stimulating hormone, luteinising hormone and DHEA-S levels before and at 3 months after commencement of HRT were measured...
September 14, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28901029/successful-venoarterial-extracorporeal-membrane-oxygenation-for-postoperative-septic-shock-in-a-child-with-liver-transplantation-a-case-report
#11
Michiko Abe, Kentaro Ide, Nao Nishimura, Satoshi Nakagawa, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara
Refractory septic shock after LT is a life-threatening complication. VA ECMO is used to treat refractory cardiorespiratory failure. We present herein the case of a 5-year-old girl with post-Kasai biliary atresia, who underwent a living donor LT and suffered refractory septic shock. VA ECMO was indicated due to progressive cardiac deterioration. After full recovery of her EF, she has been steadily improving and has shown good liver function and no neurological sequelae. This is the first report of successful VA ECMO in a post- LT patient with refractory septic shock...
September 12, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28891487/outcome-of-biliary-atresia-after-kasai-s-portoenterostomy-few-concerns-author-s-reply
#12
Rajeev Gurunath Redkar
No abstract text is available yet for this article.
August 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28891486/outcome-of-biliary-atresia-after-kasai-s-portoenterostomy-few-concerns
#13
Vikrant Sood, Seema Alam
No abstract text is available yet for this article.
August 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28878446/review-of-redo-kasai-portoenterostomy-for-biliary-atresia-in-the-transition-to-the-liver-transplantation-era
#14
REVIEW
Wataru Sumida, Hiroo Uchida, Yujiro Tanaka, Takahisa Tainaka, Chiyoe Shirota, Naruhiko Murase, Kazuo Oshima, Ryo Shirotsuki, Kousuke Chiba
Portoenterostomy (PE) is the standard therapy for biliary atresia (BA). PE offers the chance of survival to children with BA. PE was the ultimate therapeutic modality for BA before liver transplantation (LT) was available. Failure of biliary drainage with PE was almost invariably fatal in children with BA. In such cases, redo-PE was performed to salvage patients following PE failure. PE remains the standard first treatment for BA despite the availability of LT. Further, redo-PE is also performed in a limited number of cases despite the development of LT as an alternative means of PE...
August 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28871667/visualizing-the-adenylation-activities-and-protein-protein-interactions-of-aryl-acid-adenylating-enzymes
#15
Fumihiro Ishikawa, Shota Kasai, Hideaki Kakeya, Genzoh Tanabe
Structural and activity studies have revealed the dynamic and transient actions of carrier protein (CP) activity in primary and secondary metabolic pathways. CP-mediated interactions play a central role in nonribosomal peptide biosynthesis, serving as covalent tethers for amino acid and aryl acid substrates and enabling the growth of peptide intermediates. Strategies are therefore required to study protein-protein interactions efficiently. Herein, we describe activity-based probes used to demonstrate the protein-protein interactions between aryl CP (ArCP) and aryl acid adenylation (A) domains as well as the substrate specificities of aryl acid A-domains...
September 4, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28871567/a-case-of-biliary-atresia-with-pancreaticobiliary-maljunction
#16
Kosuke Endo, Akiko Yokoi, Yasuhiko Mishima, Akihiko Tamaki, Keiichi Morita, Yuichi Okata, Chieko Hisamatsu, Hiroaki Fukuzawa, Makiko Yoshida, Yoshinobu Akasaka, Kosaku Maeda
BACKGROUND: The pathogenesis of biliary atresia (BA) is still unknown. There are several reports on the etiology of BA, including pancreaticobiliary maljunction (PBM). We experienced a case of Kasai type IIIa BA with PBM, in which we found elevation of pancreatic enzymes in the gallbladder. We evaluated whether PBM is related to the pathogenesis of BA based on our findings. CASE PRESENTATION: The patient was born at 40 weeks of gestation. His body weight at birth was 2850 g...
September 5, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28870223/modified-candy-plug-technique-for-chronic-type-b-aortic-dissection-with-aneurysmal-dilatation-a-case-report
#17
Sohsyu Kotani, Yoshito Inoue, Mio Kasai, Satoru Suzuki, Takashi Hachiya
BACKGROUND: The original 'candy-plug' technique has been reported to be beneficial for the treatment of residual perfused false lumen in patients with aortic dissection. However, this technique is also associated with several problems, such as narrowing of the true lumen and damage to the flap or vessel wall. Therefore, we modified the procedure to overcome these problems. Here we report a case in which the patient was successfully treated using the modified procedure. CASE PRESENTATION: A 59-year-old man presented with chronic type B aortic dissection with aneurysmal dilatation...
September 5, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28867781/low-docosahexaenoic-acid-dihomo-gamma-linolenic-acid-and-arachidonic-acid-levels-associated-with-long-term-mortality-in-patients-with-acute-decompensated-heart-failure-in-different-nutritional-statuses
#18
Shohei Ouchi, Tetsuro Miyazaki, Kazunori Shimada, Yurina Sugita, Megumi Shimizu, Azusa Murata, Takao Kato, Tatsuro Aikawa, Shoko Suda, Tomoyuki Shiozawa, Masaru Hiki, Shuhei Takahashi, Hiroshi Iwata, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida
The clinical significance of polyunsaturated fatty acids (PUFAs) in acute decompensated heart failure (ADHF) in various nutritional statuses remains unclear. For this study, we enrolled 267 patients with ADHF admitted to the cardiac intensive care unit at Juntendo University hospital between April 2012 and March 2014. The association between long-term mortality, the geriatric nutritional risk index (GNRI), and levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), dihomo-gamma-linolenic acid (DGLA), and arachidonic acid (AA) was investigated...
August 30, 2017: Nutrients
https://www.readbyqxmd.com/read/28866979/quantification-of-plasma-phosphorylated-tau-to-use-as-a-biomarker-for-brain-alzheimer-pathology-pilot-case-control-studies-including-patients-with-alzheimer-s-disease-and-down-syndrome
#19
Harutsugu Tatebe, Takashi Kasai, Takuma Ohmichi, Yusuke Kishi, Tomoshi Kakeya, Masaaki Waragai, Masaki Kondo, David Allsop, Takahiko Tokuda
BACKGROUND: There is still a substantial unmet need for less invasive and lower-cost blood-based biomarkers to detect brain Alzheimer's disease (AD) pathology. This study is aimed to determine whether quantification of plasma tau phosphorylated at threonine 181 (p-tau181) is informative in the diagnosis of AD. METHODS: We have developed a novel ultrasensitive immunoassay to quantify plasma p-tau181, and measured the levels of plasma p-tau181 in three cohorts. RESULTS: In the first cohort composed of 20 AD patients and 15 age-matched controls, the plasma levels of p-tau181 were significantly higher in the AD patients than those in the controls (0...
September 4, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28856764/polymicrobial-bloodstream-infection-in-an-immunocompetent-child
#20
Akane Ono, Hiroshi Yamaguchi, Yusuke Ito, Masashi Kasai
No abstract text is available yet for this article.
August 30, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
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