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https://www.readbyqxmd.com/read/28811927/premature-deaths-among-individuals-with-severe-mental-illness-after-discharge-from-long-term-hospitalisation-in-japan-a-naturalistic-observation-during-a-24-year-period
#1
Shinsuke Kondo, Yousuke Kumakura, Akiko Kanehara, Daisuke Nagato, Taro Ueda, Tsuneo Matsuoka, Yukiko Tao, Kiyoto Kasai
BACKGROUND: Premature death in individuals with severe mental illness (SMI) in countries without nationally collected data, including Japan, is structurally underreported. AIMS: To elucidate excess mortality among individuals with SMI in Japan. METHOD: We retrospectively investigated all deaths among users of a non-clinical community-based mental health service provider in suburban Tokyo from 1992 to 2015. RESULTS: During the study period, 45 individuals died among 254 qualified registrants...
July 2017: BJPsych Open
https://www.readbyqxmd.com/read/28806965/decreased-circulating-dihomo-gamma-linolenic-acid-levels-are-associated-with-total-mortality-in-patients-with-acute-cardiovascular-disease-and-acute-decompensated-heart-failure
#2
Shohei Ouchi, Tetsuro Miyazaki, Kazunori Shimada, Yurina Sugita, Megumi Shimizu, Azusa Murata, Takao Kato, Tatsuro Aikawa, Shoko Suda, Tomoyuki Shiozawa, Masaru Hiki, Shuhei Takahashi, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida
BACKGROUND: Polyunsaturated fatty acids (PUFAs) have important roles in the pathogenesis of cardiovascular diseases. However, the clinical significance of omega-6 PUFAs in acute cardiovascular disease remains unknown. METHODS: We enrolled 417 consecutive patients with acute cardiovascular disease admitted to the cardiac intensive care unit at Juntendo University Hospital between April 2012 and October 2013. We investigated the association between serum PUFA levels and long-term mortality...
August 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28804741/a-case-of-dorsal-oblique-fingertip-amputation
#3
Shinsuke Takeda, Masahiro Tatebe, Akimasa Morita, Hidemasa Yoneda, Katsuyuki Iwatsuki, Hitoshi Hirata
This study reports successful finger replantation in a patient with a dorsal oblique fingertip amputation. When repairing this unique type of injury, an evaluation of the remaining vessels is more useful for successful replantation than the anatomical zone classification. We propose that Kasai's classification is appropriate for guiding treatment.
2017: Case Reports in Plastic Surgery & Hand Surgery
https://www.readbyqxmd.com/read/28804556/anti-tumor-efficacy-evaluation-of-a-novel-monoclonal-antibody-targeting-neutral-amino-acid-transporter-asct2-using-patient-derived-xenograft-mouse-models-of-gastric-cancer
#4
Noriyuki Kasai, Aya Sasakawa, Kenta Hosomi, Tze Wei Poh, Bernadette Lynn Chua, Wei Peng Yong, Jimmy So, Shing Leng Chan, Richie Soong, Koji Kono, Toshihiko Ishii, Kazuya Yamano
ASC amino acid transporter 2 (ASCT2), also known as solute linked carrier family 1 member A5 (SLC1A5) is a Na+-dependent glutamine/neutral amino acid transporter. ASCT2 acts as a high-affinity transporter of L-glutamine (Gln) and has been reported to be up-regulated in a variety of cancerous tissues including stomach, liver, and kidney. In this study, we evaluated anti-tumor efficacy of a novel anti-ASCT2 humanized monoclonal antibody, KM8094, which has a neutralizing activity against glutamine uptake, as a therapeutic antibody against gastric cancer and explored clinical predictive biomarker candidates by utilizing patient-derived xenograft (PDX) mouse models...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28796433/understanding-emergency-care-delivery-through-computer-simulation-modeling
#5
Lauren F Laker, Elham Torabi, Daniel J France, Craig M Froehle, Eric J Goldlust, Nathan R Hoot, Parastu Kasaie, Michael S Lyons, Laura H Barg-Walkow, Michael J Ward, Robert L Wears
In 2017, Academic Emergency Medicine convened a consensus conference entitled, "Catalyzing System Change through Health Care Simulation: Systems, Competency, and Outcomes." This manuscript, a product of the breakout session on "understanding complex interactions through systems modeling," explores the role that computer simulation modeling can and should play in research and development of emergency care delivery systems. This manuscript discusses areas central to the use of computer simulation modeling in emergency care research...
August 10, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28794355/characteristic-posterior-dominant-lower-limb-muscle-involvement-in-limb-girdle-muscular-dystrophy-due-to-a-dnajb6-phe93leu-mutation
#6
Yuta Kojima, Yu-Ichi Noto, Daiki Takewaki, Naoki Tokuda, Kensuke Shiga, Ai Hamano, Ikuko Mizuta, Manabu Muranishi, Takashi Kasai, Masanori Nakagawa, Toshiki Mizuno
A 41-year-old man presented with gradually progressing proximal-dominant lower limb atrophy and weakness. His brother, mother and maternal aunt had the same symptoms. A physical examination and muscle imaging (CT and ultrasound) showed selective muscle involvement of the bilateral paraspinal, gluteus and posterior groups of lower limb muscles. Based on the characteristic muscle involvement pattern, the clinical findings and the muscle biopsy results, we made a straightforward diagnosis of limb-girdle muscular dystrophy (LGMD) due to a DNAJB6 Phe93Leu mutation based on a targeted gene analysis...
August 10, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28794327/a-reactive-oxygen-nitrogen-species-sensor-fabricated-from-an-electrode-modified-with-a-polymerized-iron-porphyrin-and-a-polymer-electrolyte-membrane
#7
Ryo Matsuoka, Chihiro Kobayashi, Atsushi Nakagawa, Shigeo Aoyagi, Tatsuo Aikawa, Takeshi Kondo, Shigenobu Kasai, Makoto Yuasa
We have developed an electrochemical reactive oxygen/nitrogen species sensor that can detect superoxide anion radicals (O2(-•)) and nitric oxide (NO). The reactive oxygen/nitrogen species sensor was fabricated by surface modification of an electrode with polymerized iron tetrakis(3-thienyl)porphyrin (FeT3ThP), and it can detect either O2(-•) or NO by switching the applied potential. Furthermore, we fabricated a sensor with improved selectivity by coating a Nafion(®) film onto the poly(FeT3ThP)-modified electrode...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28780423/cinnamic-acid-derivatives-inhibit-hepatitis-c-virus-replication-via-the-induction-of-oxidative-stress
#8
Ryota Amano, Atsuya Yamashita, Hirotake Kasai, Tomoka Hori, Sayoko Miyasato, Setsu Saito, Hiromasa Yokoe, Kazunori Takahashi, Tomohisa Tanaka, Teruhime Otoguro, Shinya Maekawa, Nobuyuki Enomoto, Masayoshi Tsubuki, Kohji Moriishi
Several cinnamic acid derivatives have been reported to exhibit antiviral activity. In this study, we prepared 17 synthetic cinnamic acid derivatives and screened them to identify an effective antiviral compound against hepatitis C virus (HCV). Compound 6, one of two hit compounds, suppressed the viral replications of genotypes 1b, 2a, 3a, and 4a with EC50 values of 1.5-8.1 μM and SI values of 16.2-94.2. The effect of compound 6 on the phosphorylation of Tyr(705) in signal transducer and activator of transcription 3 (STAT3) was investigated because a cinnamic acid derivative AG490 was reported to suppress HCV replication and the activity of Janus kinase (JAK) 2...
August 2, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28765192/four-dimensional-ct-guided-transcatheter-removal-of-a-fractured-migrated-catheter-of-a-totally-implantable-venous-access-port
#9
Kazushi Fujimoto, Hajime Kasai, Toshihiko Sugiura, Koichiro Tatsumi
Patients undergoing chemotherapy usually undergo placement of a totally implantable venous access port (TIVAP), but TIVAP catheter fracture is rare. We encountered a case where flushing the TIVAP catheter became impossible because of resistance. A 61-year-old-woman underwent TIVAP placement. Although a chest X-ray revealed the fractured catheter had migrated into the right hilar area, the timing of the fracture was unclear. Four-dimensional computed tomography (4D-CT) showed that the tip of the fractured catheter was located at the anterior segmental artery of the right upper lobe and was immobile, with the remaining portion flapping with the blood flow...
August 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28762964/accurate-charge-densities-from-powder-x-ray-diffraction-a-new-version-of-the-aarhus-vacuum-imaging-plate-diffractometer
#10
Kasper Tolborg, Mads R V Jørgensen, Sebastian Christensen, Hidetaka Kasai, Jacob Becker, Peter Walter, Ann Christin Dippel, Jens Als-Nielsen, Bo B Iversen
In recent years powder X-ray diffraction has proven to be a valuable alternative to single-crystal X-ray diffraction for determining electron-density distributions in high-symmetry inorganic materials, including subtle deformation in the core electron density. This was made possible by performing diffraction measurements in vacuum using high-energy X-rays at a synchrotron-radiation facility. Here we present a new version of our custom-built in-vacuum powder diffractometer with the sample-to-detector distance increased by a factor of four...
August 1, 2017: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/28761968/a-retrospective-study-of-amrubicin-monotherapy-for-the-treatment-of-relapsed-small-cell-lung-cancer-in-elderly-patients
#11
Hisao Imai, Tomohide Sugiyama, Tomohiro Tamura, Hiroyuki Minemura, Kyoichi Kaira, Kenya Kanazawa, Hiroshi Yokouchi, Takashi Kasai, Takayuki Kaburagi, Koichi Minato
PURPOSE: Amrubicin is one of the most active chemotherapeutic drugs for small cell lung cancer (SCLC). Previous studies reported its effectiveness and severe hematological toxicity. However, the efficacy of amrubicin monotherapy in elderly patients with SCLC has not been described. The objective of this study was to investigate the feasibility of amrubicin monotherapy in elderly patients and its efficacy for relapsed SCLC. METHODS: A retrospective cohort study design was used...
July 31, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28761775/real-time-monitoring-of-superoxide-anion-radical-generation-in-response-to-wounding-electrochemical-study
#12
Ankush Prasad, Aditya Kumar, Ryo Matsuoka, Akemi Takahashi, Ryo Fujii, Yamato Sugiura, Hiroyuki Kikuchi, Shigeo Aoyagi, Tatsuo Aikawa, Takeshi Kondo, Makoto Yuasa, Pavel Pospíšil, Shigenobu Kasai
BACKGROUND: The growth and development of plants is deleteriously affected by various biotic and abiotic stress factors. Wounding in plants is caused by exposure to environmental stress, mechanical stress, and via herbivory. Typically, oxidative burst in response to wounding is associated with the formation of reactive oxygen species, such as the superoxide anion radical (O2(•-)), hydrogen peroxide (H2O2) and singlet oxygen; however, few experimental studies have provided direct evidence of their detection in plants...
2017: PeerJ
https://www.readbyqxmd.com/read/28755030/the-human-vascular-endothelial-cell-line-huv-ec-c-harbors-the-integrated-hhv-6b-genome-which-remains-stable-in-long-term-culture
#13
Setsuko Shioda, Fumio Kasai, Midori Ozawa, Noriko Hirayama, Motonobu Satoh, Yousuke Kameoka, Ken Watanabe, Norio Shimizu, Huamin Tang, Yasuko Mori, Arihiro Kohara
Human herpes virus 6 (HHV-6) is a common human pathogen that is most often detected in hematopoietic cells. Although human cells harboring chromosomally integrated HHV-6 can be generated in vitro, the availability of such cell lines originating from in vivo tissues is limited. In this study, chromosomally integrated HHV-6B has been identified in a human vascular endothelial cell line, HUV-EC-C (IFO50271), derived from normal umbilical cord tissue. Sequence analysis revealed that the viral genome was similar to the HHV-6B HST strain...
July 28, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28754894/a-cancer-stem-cell-model-as-the-point-of-origin-of-cancer-associated-fibroblasts-in-tumor-microenvironment
#14
Neha Nair, Anna Sanchez Calle, Maram Hussein Zahra, Marta Prieto-Vila, Aung Ko Ko Oo, Laura Hurley, Arun Vaidyanath, Akimasa Seno, Junko Masuda, Yoshiaki Iwasaki, Hiromi Tanaka, Tomonari Kasai, Masaharu Seno
Cancer-associated fibroblasts (CAFs) are one of the most prominent cell types in the stromal compartment of the tumor microenvironment. CAFs support multiple aspects of cancer progression, including tumor initiation, invasion, and metastasis. The heterogeneous nature of the stromal microenvironment is attributed to the multiple sources from which the cells in this compartment originate. The present study provides the first evidence that cancer stem cells (CSCs) are one of the key sources of CAFs in the tumor niche...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28754502/the-impact-of-musculoskeletal-diseases-on-mortality-comparison-with-internal-diseases-a-15-year-longitudinal-study
#15
Takehiro Kasai, Yukiharu Hasegawa, Shiro Imagama, Tadahiro Sakai, Kenji Wakai, Koji Suzuki, Naoki Ishiguro
BACKGROUND: Aging is associated with an increased incidence of diabetes (DM), hypertension (HT), hyperlipidemia (HL), as well as musculoskeletal disorders, such as osteoarthritis (OA) and osteoporosis (OP). However, the impact of musculoskeletal disorders on mortality remains unclear. This study investigated the risk of mortality if having knee OA or OP. METHODS: 601 participants (mean age 67.8 ± 5.3 years) who underwent musculoskeletal check-ups in Yakumo town were enrolled in this study, 248 were males and 353 were females...
July 25, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28750093/correction-optimal-costs-of-hiv-pre-exposure-prophylaxis-for-men-who-have-sex-with-men
#16
Jennie McKenney, Anders Chen, Karen W Hoover, Jane Kelly, David Dowdy, Parastu Kasaie, Patrick S Sullivan, Eli S Rosenberg
[This corrects the article DOI: 10.1371/journal.pone.0178170.].
2017: PloS One
https://www.readbyqxmd.com/read/28746265/prevalence-of-rubella-antibodies-among-children-in-the-democratic-republic-of-the-congo
#17
Vivian H Alfonso, Reena H Doshi, Patrick Mukadi, Stephen G Higgins, Nicole A Hoff, Ado Bwaka, Guillaume Ngoie Mwamba, Emile Okitolonda, Jean-Jacques Muyembe, Sue Gerber, Anne W Rimoin
BACKGROUND: While generally mild in children, rubella infection in early pregnancy can lead to miscarriage, fetal death or congenital rubella syndrome (CRS). Rubella vaccination is not yet available as a part of routine immunization in the Democratic Republic of the Congo (DRC) and the burden of infection is unknown. METHODS: In collaboration with the 2013-2014 DRC Demographic and Health Survey (DHS), a serosurvey was carried out to assess population immunity to vaccine preventable diseases...
July 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28746031/incidence-of-biliary-atresia-and-timing-of-hepatoportoenterostomy-in-the-united-states
#18
Perri C Hopkins, Nada Yazigi, Cade M Nylund
OBJECTIVE: To evaluate the incidence, trends, seasonality, and age at the time of hepatoportoenterostomy (Kasai procedure) for biliary atresia in the US. STUDY DESIGN: The triennial Health Cost and Utilization Project-Kids' Inpatient Database for 1997-2012 was used to perform a retrospective analysis of biliary atresia in the US. Infants aged <1 year of age with a diagnosis of biliary atresia who underwent a Kasai procedure were included. Nationwide infant population data were used to calculate incidence and evaluate trends...
August 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28745269/hepatitis-b-virus-prevents-excessive-viral-production-via-reduction-of-cell-death-inducing-dff45-like-effectors
#19
Jun Yasumoto, Hirotake Kasai, Kentaro Yoshimura, Teruhime Otoguro, Koichi Watashi, Takaji Wakita, Atsuya Yamashita, Tomohisa Tanaka, Sen Takeda, Kohji Moriishi
The relationship between hepatitis B virus (HBV) infection and lipid accumulation remains largely unknown. In this study, we investigated the effect of HBV propagation on lipid droplet growth in HBV-infected cells and HBV-producing cell lines, HepG2.2.15 and HBV-inducible Hep38.7-Tet. The amount of intracellular triglycerides was significantly reduced in HBV-infected and HBV-producing cells compared with HBV-lacking control cells. Electron and immunofluorescent microscopic analyses showed that the average size of a single lipid droplet (LD) was significantly less in the HBV-infected and HBV-producing cells than in the HBV-lacking control cells...
July 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28740824/associations-between-daily-living-skills-cognition-and-real-world-functioning-across-stages-of-schizophrenia-a-study-with-the-schizophrenia-cognition-rating-scale-japanese-version
#20
Yuko Higuchi, Tomiki Sumiyoshi, Tomonori Seo, Motomu Suga, Tsutomu Takahashi, Shimako Nishiyama, Yuko Komori, Kiyoto Kasai, Michio Suzuki
Cognitive function is impaired in patients with schizophrenia-spectrum disorders, even in their prodromal stages. Specifically, the assessment of cognitive abilities related to daily-living functioning, or functional capacity, is important to predict long-term outcome. In this study, we sought to determine the validity of the Schizophrenia Cognition Rating Scale (SCoRS) Japanese version, an interview-based measure of cognition relevant to functional capacity (i.e. co-primary measure). For this purpose, we examined the relationship of SCoRS scores with performance on the Brief Assessment of Cognition in Schizophrenia (BACS) Japanese version, a standard neuropsychological test battery, and the Social and Occupational Functioning Assessment Scale (SOFAS), an interview-based social function scale...
March 2017: Schizophrenia Research. Cognition
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