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JOURNAL ARTICLE
Misuzu Fujita, Kengo Nagashima, Minobu Shimazu, Misae Suzuki, Ichiro Tauchi, Miwa Sakuma, Setsuko Yamamoto, Hideki Hanaoka, Makio Shozu, Nobuhide Tsuruoka, Tokuzo Kasai, Akira Hata
Japan is lagging in cervical cancer prevention. The effectiveness of a self-sampling human papillomavirus (HPV) test, a possible measure to overcome this situation, has not yet been evaluated. A randomized controlled trial was performed to evaluate the effectiveness of a self-sampling HPV test on detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and screening uptake. Women between 30 and 58 years old who did not participate in the cervical cancer screening program for ≥3 years were eligible and assigned to the intervention group (cytology or self-sampling HPV test) or control group (cytology)...
April 22, 2024: International Journal of Cancer. Journal International du Cancer
#2
JOURNAL ARTICLE
Yu Kawasaki, Takatoshi Kasai, Yuko Sakurama, Fusae Kawana, Nanako Shiroshita, Natsue Koikawa
PURPOSE: Female athletes with menstrual abnormalities have poor sleep quality. However, whether female athletes with poor sleep quality based on subjective assessment have distinctive changes in objective measures of sleep in association with menses remains unclear. This study aimed to compare changes in objective sleep measurements during and following menses between collegiate female athletes with and without poor subjective sleep quality. PATIENTS AND METHODS: Female collegiate athletes (age range/mean ± standard deviation: 18-22/ 22...
2024: Nature and Science of Sleep
#3
REVIEW
Adriana Bastos Carvalho, Tais Hanae Kasai-Brunswick, Antonio Carlos Campos de Carvalho
We review the evidence for the presence of stem/progenitor cells in the heart and the preclinical and clinical data using diverse cell types for the therapy of cardiac diseases. We highlight the failure of adult stem/progenitor cells to ameliorate heart function in most cardiac diseases, with the possible exception of refractory angina. The use of pluripotent stem cell-derived cardiomyocytes is analysed as a viable alternative therapeutic option but still needs further research at preclinical and clinical stages...
April 18, 2024: EBioMedicine
#4
JOURNAL ARTICLE
Fumio Kasai, Makoto Fukushima, Yohei Miyagi, Yukio Nakamura
Japan is often assumed to have a highly homogeneous ethnic population, because it is an island country. This is evident in human cell lines collected from cell banks; however, these genotypes have not been thoroughly characterized. To examine the population genotypes of human cell lines established in Japan, we conducted SNP genotyping on 57 noncancerous cell lines and 43 lung cancer cell lines. Analysis of biogeographic ancestry revealed that 58 cell lines had non-admixed Japanese genotypes, 21 cell lines had an admixture of Japanese and East Asian genotypes, and the remaining 21 cell lines had East Asian genotypes...
April 19, 2024: Human Cell
#5
JOURNAL ARTICLE
Shunsuke Kasai, Etsuko Sato, Chikara Sakaguchi, Yasutsuna Sasaki
Tumor lysis syndrome (TLS) is a fatal complication associated with chemotherapy. We herein report a case of TLS in a 73-year-old woman with metastatic BRAFV600E mutated colon cancer after she received combined treatment with cetuximab and encorafenib. The serum uric acid, urea nitrogen, and creatinine levels were elevated on day four of the first cycle. The fibrin degradation product (FDP) and D-dimer levels were also high. Diuresis and rasburicase were initiated for TLS, and the laboratory data all normalized on day 8...
April 16, 2024: Internal Medicine
#6
REVIEW
Jeffrey Tanudji, Hideaki Kasai, Michio Okada, Tetsuo Ogawa, Susan M Aspera, Hiroshi Nakanishi
Targeted alpha therapy (TAT) is a methodology that is being developed as a promising cancer treatment using the α-particle decay of radionuclides. This technique involves the use of heavy radioactive elements being placed near the cancer target area to cause maximum damage to the cancer cells while minimizing the damage to healthy cells. Using gold nanoparticles (AuNPs) as carriers, a more effective therapy methodology may be realized. AuNPs can be good candidates for transporting these radionuclides to the vicinity of the cancer cells since they can be labeled not just with the radionuclides, but also a host of other proteins and ligands to target these cells and serve as additional treatment options...
April 17, 2024: Physical Chemistry Chemical Physics: PCCP
#7
JOURNAL ARTICLE
Kenichiro Takeda, Hajime Kasai, Hiroshi Tajima, Nami Hayama, Mikihito Saito, Chiaki Kawame, Takuji Suzuki
BACKGROUND: The usefulness of lung ultrasound (LUS) has been demonstrated. However, it is unclear whether diagnostic techniques using LUS are accepted by all physicians. A simple simulation-based educational program may improve the LUS skills of beginners, but it has not been fully assessed. OBJECTIVE: This prospective study was conducted to assess the educational outcomes of LUS training using a high-fidelity simulator. METHODS: A simulator-based program for LUS was conducted...
March 2024: ATS scholar
#8
Sangamitra Rajasekaran, Hari Neupane, Monika Bawa, Uma Nahar Saikia, Sadhna Lal, Suvradeep Mitra
Biliary atresia (BA) is a fibro-obliterative cholestatic disease of infancy. The presence of cartilage in the resected tissue is an uncommon finding. We documented the presence of both mature and immature hyaline cartilage in the portal plate and the wall of the gallbladder in a 2-month-old girl infant with BA who had undergone Kasai portoenterostomy. The presence of cartilage could be part of a heterotopia or an uncommon connective tissue metaplasia. The presence of immature cartilage with the merging of the perichondrium with the soft tissue highlights a metaplastic etiology in the index case...
2024: Autopsy & Case Reports
#9
JOURNAL ARTICLE
Urara Saito, Shogo Minamikawa, Shogo Otake, Yusuke Ishida, Mao Mizuta, Toshiaki Ishida, Shuhei Karakawa, Masashi Kasai, Yasuo Nakagishi
The clinical features of panniculitis caused by Pseudomonas aeruginosa, in contrast to those caused by ecthyma gangrenosum, remain unknown. Here, we report a pediatric case of P. aeruginosa panniculitis. The patient had systemic involvement without bacteremia and also had a background of autoimmune neutropenia. These features are common in ecthyma gangrenosum but have not been reported in P. aeruginosa-induced panniculitis.
April 10, 2024: Pediatric Infectious Disease Journal
#10
JOURNAL ARTICLE
Naoya Igarashi, Kaichi Kasai, Yuki Tada, Koudai Kani, Miyuna Kato, Shun Takano, Kana Goto, Yudai Matsuura, Mayuko Ichimura-Shimizu, Shiro Watanabe, Koichi Tsuneyama, Yukihiro Furusawa, Yoshinori Nagai
BACKGROUND: Tsumura-Suzuki non-obese (TSNO) mice exhibit a severe form of metabolic dysfunction-associated steatohepatitis (MASH) with advanced liver fibrosis upon feeding a high-fat/cholesterol/cholate-based (iHFC) diet. Another ddY strain, Tsumura-Suzuki diabetes obese (TSOD) mice, are impaired in the progression of iHFC diet-induced MASH. AIM: To elucidate the underlying mechanisms contributing to the differences in MASH progression between TSNO and TSOD mice...
April 15, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
#11
JOURNAL ARTICLE
Yi Zou Lim, Kevin Mutore, Maria Valencia Bradd, Samir Pandya, Natasha Corbitt
BACKGROUND: Biliary atresia is the most common cause of obstructive jaundice in infants and conventional cholangiography is the current diagnostic gold standard. Fluorescent cholangiography with indocyanine green can enhance biliary tree visualization during surgery because it is exclusively excreted into the bile ducts and eventually into the intestine. Therefore, we hypothesized that indocyanine green presence in stool could confirm bile duct patency in infants. METHODS: A prospective single center cohort study was performed on infants (age ≤ 12 months) with and without jaundice after obtaining IRB approval...
March 20, 2024: Journal of Pediatric Surgery
#12
JOURNAL ARTICLE
Yuichi Kasai, Permsak Paholpak, Taweechok Wisanuyotin, Nuttharada Sukitthanakornkul, Parika Hanarwut, Arada Chaiyamoon, Sitthichai Iamsaard, Akinobu Nishimura
BACKGROUND: As the anatomical variations of the foot, enlarged peroneal tubercle (EPT) and accessory anterolateral talar facet (AALTF) have attracted the attention of foot surgeons in recent years. However, EPT and AALTF have not been examined for a relationship with calcaneus spur (CS) as a common osteophyte. METHODS: The subjects were 369 individuals who died in northeastern Thailand and were preserved as skeletal specimens. The authors examined for the presence of left and right EPT, AALTF, and calcaneus spur (CS)...
April 12, 2024: Journal of Orthopaedic Surgery and Research
#13
JOURNAL ARTICLE
Yusuke Takashima, Hitoshi Hino, Akio Shiomi, Hiroyasu Kagawa, Shoichi Manabe, Yusuke Yamaoka, Chikara Maeda, Shunsuke Kasai, Yusuke Tanaka
BACKGROUND: Stoma prolapse (SP) is a common stoma-related complication, particularly in loop colostomies. This study aimed to investigate potential risk factors for SP development after laparoscopic loop colostomy. METHODS: In total, data from 140 patients who underwent laparoscopic loop colostomy were analyzed between September 2016 and March 2022. Risk factors for SP were investigated retrospectively. RESULTS: The median follow-up duration after colostomy was 12...
April 11, 2024: Surgical Endoscopy
#14
JOURNAL ARTICLE
Fumihito Kasai, Takahisa Kobayashi, Eriko Hoshi, Takashi Nagai, Takeshi Yamashita, Koji Otsuka, Masahiko Murakami, Nobuyuki Kawate
OBJECTIVES: At our hospital, prehabilitation has been provided to patients undergoing esophageal cancer surgery since October 2019. This study explored the effects of prehabilitation based on the accumulated database of these patients. METHODS: This retrospective cohort study included 621 patients who underwent thoracoscopic subtotal esophagectomy. Multiple linear regression analysis was performed using postoperative hospital stay as the objective variable and age, sex, body mass index (BMI), preoperative ventilatory impairment, left ventricular ejection fraction, preoperative hemoglobin A1c, clinical stage, histological type, operative time, surgical blood loss, postoperative complications, and prehabilitation as explanatory variables...
2024: Progress in rehabilitation medicine
#15
JOURNAL ARTICLE
Aline Marcadenti, Rachel H Vieira Machado, Renato Hideo Nakagawa Santos, Caio Cesar Dos Santos Kasai, Cristiane Kovacs, Annie Bello, Cristina H de Matos, Renata Torres Abib Bertacco, Gabriela C Souza, Gabriela da S Schirmann, Francisca Eugenia Zaina Nagano, Soraia Poloni, Raquel Milani El Kik, Naoel Hassan Feres, Isa G Rodrigues, Antônio Carlos Sobral Sousa, Josilene M F Pinheiro, Sandra Mary Lima Vasconcelos, Daniele Maria de Oliveira Carlos, Viviane Sahade Souza, Adriana Barros Gomes, José Albuquerque de Figueiredo Neto, Emilio Hideyuki Moriguchi, Maria Cristina Izar, Sônia Lopes Pinto, Josefina Bressan, Simone Raimondi de Souza, Magali C Kumbier, Celme Barroncas Passos de Araújo, Camila R Torreglosa, Bernardete Weber, Ângela Cristine Bersch-Ferreira
BACKGROUND: Adhering to a diet adequate in macronutrients is crucial for the secondary prevention of cardiovascular diseases. OBJECTIVE: To assess the prevalence of adherence to recommendations for the consumption of dietary fatty acids for the prevention and treatment of cardiovascular diseases and to estimate whether the presence of certain cardiovascular risk factors would be associated with adherence. METHODS: Cross-sectional study using baseline data from 2,358 participants included in the "Brazilian Cardioprotective Nutritional Program Trial"...
2024: Arquivos Brasileiros de Cardiologia
#16
JOURNAL ARTICLE
Yue Guo, Yutaka Kasai, Yuto Tanaka, Yuki Ohashi-Kumagai, Takeharu Sakamoto, Takeshi Ito, Yoshinori Murakami
The immunoglobulin superfamily (IgSF) is one of the largest families of cell-surface molecules involved in various cell-cell interactions, including cancer-stromal interactions. In this study, we undertook a comprehensive RT-PCR-based screening for IgSF molecules that promote experimental lung metastasis in mice. By comparing the expression of 325 genes encoding cell-surface IgSF molecules between mouse melanoma B16 cells and its highly metastatic subline, B16F10 cells, we found that expression of the immunoglobulin superfamily member 3 gene (Igsf3) was significantly enhanced in B16F10 cells than in B16 cells...
April 9, 2024: Cancer Science
#17
JOURNAL ARTICLE
Kiyoyuki Ogata, Yuto Mochimaru, Nana Kasai, Kazuma Sei, Naoya Kawahara, Mika Ogata, Yumi Yamamoto
Bone marrow (BM) examination is a key element in the diagnosis and prognostic grading of myelodysplastic syndromes (MDSs), and obtaining adequate BM cell samples is critical for accurate test results. Massive haemodilution of aspirated BM samples is a well-known problem; however, its incidence in patients with MDS has not been well studied. We report the first study to examine the incidence of massive haemodilution in nationwide BM samples aspirated from patients diagnosed with or suspected of MDS in Japan...
April 8, 2024: British Journal of Haematology
#18
JOURNAL ARTICLE
Naseem Ravanbakhsh, Catherine A Chapin, Yun Li, Ravi Jhaveri
For patients with Biliary atresia, antibiotic prophylaxis after Kasai portoenterostomy is a common practice. Societal guidelines often cite one reference as supportive evidence for this practice. In this paper, we go back to review the quality of this evidence and suggest more research is required to demonstrate the efficacy of antibiotic prophylaxis in this population.
April 8, 2024: Journal of the Pediatric Infectious Diseases Society
#19
JOURNAL ARTICLE
Willem S Lexmond, Henkjan J Verkade
No abstract text is available yet for this article.
April 8, 2024: Journal of Pediatric Gastroenterology and Nutrition
#20
JOURNAL ARTICLE
Kazuya Takahashi, Thao Thu Thi Nguyen, Atsushi Watanabe, Hiroki Sato, Kinuko Saito, Minori Tamai, Daisuke Harama, Shin Kasai, Koshi Akahane, Kumiko Goi, Keiko Kagami, Masako Abe, Chiaki Komatsu, Yasuhiro Maeda, Kanji Sugita, Takeshi Inukai
BACKGROUND: Adhesion of cancer cells to extracellular matrix laminin through the integrin superfamily reportedly induces drug resistance. Heterodimers of integrin α6 (CD49f) with integrin β1 (CD29) or β4 (CD104) are major functional receptors for laminin. Higher CD49f expression is reportedly associated with a poorer response to induction therapy in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Moreover, a xenograft mouse model transplanted with primary BCP-ALL cells revealed that neutralized antibody against CD49f improved survival after chemotherapy...
April 2024: Cancer reports
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