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https://www.readbyqxmd.com/read/28727655/preterm-infants-with-biliary-atresia-a-nationwide-cohort-analysis-from-the-netherlands
#1
Daan B E van Wessel, Thomas Boere, Christian V Hulzebos, Ruben H J de Kleine, Henkjan J Verkade, Jan B F Hulscher
OBJECTIVES: atresia (BA) occurs in 0.54/10.000 of overall live births in The Netherlands. BA has an unfavorable prognosis: less than 40% of patients are cleared of jaundice after Kasai portoenterostomy (KPE), 4-year transplant-free survival rate is 46% and the 4-year survival rate is ∼75%. Little is known on difficulties in diagnosis and the outcome of BA in preterm infants. We aimed to analyze the incidence and outcome of BA in preterm infants in The Netherlands. METHODS: Retrospective study including Dutch preterm infants treated for BA...
July 19, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28709499/increased-occipital-gyrification-and-development-of-psychotic-disorders-in-individuals-with-an-at-risk-mental-state-a%C3%A2-multicenter-study
#2
Daiki Sasabayashi, Yoichiro Takayanagi, Tsutomu Takahashi, Shinsuke Koike, Hidenori Yamasue, Naoyuki Katagiri, Atsushi Sakuma, Chika Obara, Mihoko Nakamura, Atsushi Furuichi, Mikio Kido, Yumiko Nishikawa, Kyo Noguchi, Kazunori Matsumoto, Masafumi Mizuno, Kiyoto Kasai, Michio Suzuki
BACKGROUND: Anomalies of brain gyrification have been reported in schizophrenia, possibly reflecting its neurodevelopmental pathology. However, it remains elusive whether individuals at risk for psychotic disorders exhibit deviated gyrification patterns, and whether such findings, if present, are predictive of transition to psychotic disorders. METHODS: This multicenter magnetic resonance imaging study investigated brain gyrification and its relationship to later transition to psychotic disorders in a large sample of at-risk mental state (ARMS) individuals...
July 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28705491/proposal-of-selection-criteria-for-operative-resection-of-hepatocellular-carcinoma-with-inferior-vena-cava-tumor-thrombus-incorporating-hepatic-arterial-infusion-chemotherapy
#3
Yosuke Kasai, Etsuro Hatano, Satoru Seo, Kojiro Taura, Kentaro Yasuchika, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
BACKGROUND: Because operative resection of hepatocellular carcinoma with inferior vena cava tumor thrombus has been associated with a substantial risk of recurrence and postoperative morbidity, adequate patient selection for resection is necessary. Our aim was to propose selection criteria for resection of hepatocellular carcinoma with inferior vena cava tumor thrombus. METHODS: Long-term outcomes were analyzed retrospectively in 39 operative cases of hepatocellular carcinoma with inferior vena cava tumor thrombus (1996-2015)...
July 10, 2017: Surgery
https://www.readbyqxmd.com/read/28705306/riociguat-for-patients-with-chronic-thromboembolic-pulmonary-hypertension-usefulness-of-transitioning-from-phosphodiesterase-type-5-inhibitor
#4
Keiko Yamamoto, Nobuhiro Tanabe, Rika Suda, Akane Sasaki, Akane Matsumura, Ryogo Ema, Hajime Kasai, Fumiaki Kato, Ayumi Sekine, Rintaro Nishimura, Takayuki Jujo, Toshihiko Sugiura, Ayako Shigeta, Seiichiro Sakao, Koichiro Tatsumi
BACKGROUND: Riociguat, the first approved drug for patients with chronic thromboembolic pulmonary hypertension (CTEPH), is a soluble guanylate cyclase (sGC) Stimulator. It directly stimulates sGC independently of nitric oxide (NO) and increases sGC sensitivity for NO. The safety and efficacy of transitioning from a phosphodiesterase 5 inhibitor (PDE5i) to riociguat is unknown. METHODS AND RESULTS: Twenty-three patients were prospectively enrolled: 8 symptomatic patients with inadequate clinical responses to PDE5i were changed to riociguat (transitioned group); 15 started riociguat anew (new or add-on group)...
July 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28704315/appetite-regulations-after-sprint-exercise-under-hypoxic-condition-in-female-athletes
#5
Chihiro Kojima, Nobukazu Kasai, Aya Ishibashi, Yukako Murakami, Kumiko Ebi, Kazushige Goto
The present study determined changes in appetite-regulating hormones and energy intake after high-intensity interval exercise (HIIT) under hypoxic conditions in trained female athletes. Fifteen female athletes completed three trials on different days of either HIIT under hypoxic conditions (HYP), HIIT under normoxic conditions (NOR), or rest in normoxia (CON). Exercise trials consisted of two successive sets of eight repeated bouts of a 6-s maximal sprint separated by a 30-s rest. Blood samples were obtained to measure plasma acylated ghrelin, glucagon-like peptide-1 (GLP-1), and metabolite concentrations...
July 12, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28701223/low-dose-immunoglobulin-g-is-not-associated-with-mortality-in-patients-with-sepsis-and-septic-shock
#6
Yusuke Iizuka, Masamitsu Sanui, Yusuke Sasabuchi, Alan Kawarai Lefor, Mineji Hayakawa, Shinjiro Saito, Shigehiko Uchino, Kazuma Yamakawa, Daisuke Kudo, Kohei Takimoto, Toshihiko Mayumi, Takeo Azuhata, Fumihito Ito, Shodai Yoshihiro, Katsura Hayakawa, Tsuyoshi Nakashima, Takayuki Ogura, Eiichiro Noda, Yoshihiko Nakamura, Ryosuke Sekine, Yoshiaki Yoshikawa, Motohiro Sekino, Keiko Ueno, Yuko Okuda, Masayuki Watanabe, Akihito Tampo, Nobuyuki Saito, Yuya Kitai, Hiroki Takahashi, Iwao Kobayashi, Yutaka Kondo, Wataru Matsunaga, Sho Nachi, Toru Miike, Hiroshi Takahashi, Shuhei Takauji, Kensuke Umakoshi, Takafumi Todaka, Hiroshi Kodaira, Kohkichi Andoh, Takehiko Kasai, Yoshiaki Iwashita, Hideaki Arai, Masato Murata, Masahiro Yamane, Kazuhiro Shiga, Naoto Hori
BACKGROUND: The administration of low-dose intravenous immunoglobulin G (IVIgG) (5 g/day for 3 days; approximate total 0.3 g/kg) is widely used as an adjunctive treatment for patients with sepsis in Japan, but its efficacy in the reduction of mortality has not been evaluated. We investigated whether the administration of low-dose IVIgG is associated with clinically important outcomes including intensive care unit (ICU) and in-hospital mortality. METHODS: This is a post-hoc subgroup analysis of data from a retrospective cohort study, the Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study...
July 13, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28700458/perceived-stress-depressive-symptoms-and-oxidative-dna-damage
#7
Chisato Shimanoe, Megumi Hara, Yuichiro Nishida, Hinako Nanri, Mikako Horita, Yosuke Yamada, Yun-Shan Li, Hiroshi Kasai, Kazuaki Kawai, Yasuki Higaki, Keitaro Tanaka
OBJECTIVE: Psychosocial stress may influence the risk of disease through its association with oxidative DNA damage. We examined whether perceived stress and depressive symptoms were associated with urinary excretion of 8-hydroxydeoxyguanosine (8-OHdG), with mutual interaction on 8-OHdG. METHODS: This cross-sectional study included 6,517 individuals aged 45-74 years who participated, between 2010 and 2012, in a follow-up survey of an ongoing cohort study. Perceived stress during the past year was measured using a self-report questionnaire...
July 12, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28699603/infants-with-extrahepatic-biliary-atresia-effect-of-follow-up-on-the-survival-rate-at-ege-university-medical-school-transplantation-center
#8
Miray Karakoyun, Maşallah Baran, Caner Turan, Murat Kılıç, Orkan Ergun, Sema Aydoğdu
BACKGROUND/AIMS: Biliary atresia (BA) is the main cause of neonatal cholestasis and the primary reason for infant liver transplants worldwide. It is an obliterative cholangiopathy observed only in children and caused by progressive inflammation and fibrosis of the bile duct. We collaborated with a liver transplantation center to investigate the effects of follow-up in patients with BA. MATERIALS AND METHODS: Medical records of 99 patients who were diagnosed with BA and monitored at our center from 1990 to 2002 (27 patients) and from 2003 to 2015 (72 patients) were analyzed retrospectively...
July 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28694009/role-of-dual-red-imaging-to-guide-intravariceal-sclerotherapy-injection-of-esophageal-varices-with-videos
#9
Yoshihiro Furuichi, Takuji Gotoda, Yoshitaka Kasai, Hirohito Takeuchi, Yuu Yoshimasu, Takashi Kawai, Takao Itoi
BACKGROUND AND AIMS: Dual red imaging (DRI) is a novel image-enhanced endoscopy technique that can increase the visibility and predict the depth of esophageal varices (EVs). The recurrence rate of EVs after endoscopic injection sclerotherapy (EIS) reportedly decreases by intravariceal injection of a sclerosant. We evaluated prospectively whether the EIS success rate was increased by DRI compared with the white light (WLI) mode. METHODS: A total of 79 EV patients were randomly divided into the DRI (n = 40) and WLI (n = 39) groups...
July 7, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28693250/bcl-2-bcl-xl-inhibitor-abt-737-sensitizes-pancreatic-ductal-adenocarcinoma-to-paclitaxel-induced-cell-death
#10
Shuya Kasai, Takuya Sasaki, Ayano Watanabe, Masao Nishiya, Shinji Yasuhira, Masahiko Shibazaki, Chihaya Maesawa
Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignant disease that is resistant to various chemotherapeutic agents and commonly relapses. Efficient elimination of metastasized PDA is critical for a positive post-surgical treatment outcome. The present study analyzed the effect of the B-cell lymphoma-2 (Bcl-2)/B-cell lymphoma extra-large (Bcl-xL) inhibitor, ABT-737, on paclitaxel-induced PDA cell death. A total of 8 PDA cell lines were subjected to immunoblotting to compare the expression of Bcl-2/Bcl-xL and other factors associated with taxane resistance, including myeloid cell leukemia 1 and βIII-tubulin (TUBB3)...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692185/an-application-of-functional-near-infrared-spectroscopy-as-supplementary-examination-for-diagnosis-of-clinical-stages-of-psychosis-spectrum
#11
Shinsuke Koike, Satomura Yoshihiro, Shingo Kawasaki, Yukika Nishimura, Akihide Kinoshita, Hanako Sakurada, Mika Yamagishi, Eriko Ichikawa, Jun Matsuoka, Naohiro Okada, Ryu Takizawa, Kiyoto Kasai
AIM: Research efforts aiming at neuroimaging-aided differential diagnosis for psychiatric disorders have been progressing rapidly. A previous multisite study has developed supplementary diagnostic system using functional near-infrared spectroscopy (fNIRS) that can be easily applied to clinical settings. However, few neuroimaging biomarkers have been developed for psychosis spectrum with various clinical stages. METHODS: We employed the fNIRS as a clinical examination device for 143 participants, comprising 47 ultra-high risk (UHR) individuals, 30 patients with first-episode psychosis (FEP), 34 patients with chronic schizophrenia (ChSZ), and 33 healthy controls, who were independent of the previous study...
July 10, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28690638/fat-soluble-vitamin-deficiency-in-pediatric-patients-with-biliary-atresia
#12
Rui Dong, Song Sun, Xiao-Zhou Liu, Zhen Shen, Gong Chen, Shan Zheng
OBJECTIVE: To analyze the levels of fat-soluble vitamins (FSVs) in pediatric patients with biliary atresia (BA) before and after the Kasai procedure. METHODS: Pediatric patients with obstructive jaundice were enrolled in this study. The FSV levels and liver function before, 2 weeks after, and 1, 3, and 6 months after the Kasai procedure were measured. RESULTS: FSV deficiency was more obvious in patients with BA than in patients with other cholestatic liver diseases, especially vitamin D deficiency...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28688656/notch-signaling-promotes-ductular-reactions-in-biliary-atresia
#13
Jessica A Zagory, William Dietz, Alex Park, Michael Fenlon, Jiabo Xu, Sarah Utley, Nirmala Mavila, Kasper S Wang
BACKGROUND: Biliary atresia (BA) is a congenital, progressive, fibro-obliterative disease of the extrahepatic biliary tree and the most common cause of end-stage liver disease in children. BA is characterized by extensive intrahepatic proliferating ductular reactions that may contribute to biliary fibrosis. Lineage tracing during experimental cholestasis indicates that cells within ductular reactions derive from PROM1-expressing hepatic progenitor cells. Given the role of Notch signaling in normal biliary development, we hypothesize that activated Notch signaling promotes the formation of ductular reactions in BA...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28688394/stereodirectional-images-of-molecules-oriented-by-a-variable-voltage-hexapolar-field-fragmentation-channels-of-2-bromobutane-electronically-excited-at-two-photolysis-wavelengths
#14
Masaaki Nakamura, Shiun-Jr Yang, King-Chuen Lin, Toshio Kasai, Dock-Chil Che, Andrea Lombardi, Federico Palazzetti, Vincenzo Aquilanti
The asymmetric-top molecule 2-bromobutane is oriented by means of a hexapole state selector; the angular distribution of the bromine atom photofragment, for the two fine-structure components, is acquired by velocity-map ion imaging. The molecular beam, spatially oriented along the time-of-flight axis, is intersected with a linearly polarized laser, whose polarization is tilted by 45° with respect to the detector surface. To obtain the mixing ratio of the perpendicular and parallel transitions, the fragment ion images and angular distributions can be appropriately simulated to give insight on the population mechanism of the specific electronic state involved at each selected excitation wavelength...
July 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28688191/association-between-long-term-native-liver-survival-in-infants-with-biliary-atresia-and-use-of-a-stool-color-card-a-case-control-study
#15
Yan-Hong Gu, Akira Matsui
BACKGROUND: So far, there is no epidemiological study to determine whether long-term native liver survival (NLS) in infants with biliary atresia (BA) is associated with use of a stool color card (SCC). METHODS: A case-control study was performed in Tochigi Prefecture and two associations for patients with BA in Japan. Participants were patients with BA who born and underwent their first open Kasai procedures (KPs) from August 1994 to March 2011 in both Tochigi Prefecture and two associations for patients with BA in Japan...
July 8, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28685786/on-chip-cell-sorting-by-high-speed-local-flow-control-using-dual-membrane-pumps
#16
Shinya Sakuma, Yusuke Kasai, Takeshi Hayakawa, Fumihito Arai
Although researchers have proposed various methods of on-chip cell sorting, high-throughput sorting of large cells remains hampered by the difficulty of controlling high-speed flow over a wide sorting area. To overcome this problem, we proposed high-speed local-flow control using dual membrane pumps driven by piezoelectric actuators placed on the outside of a microfluidic chip in this paper. We evaluated the controllability of shifting the flow profile by the local-flow. The results indicated that we could sort large cells up to approximately 150 μm in size with an equivalent throughput of 31 kHz...
July 7, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28681102/four-myxobolus-spp-myxosporea-bivalvulida-from-the-gill-lamellae-of-common-carp-cyprinus-carpio-and-japanese-silver-crucian-carp-carassius-langsdorfii-in-the-western-part-of-japan-with-the-description-of-three-new-species-m-tanakai-n-sp-m-paratoyamai-n-sp-and
#17
Eigo Kato, Akihiro Kasai, Hisayuki Tomochi, Ying-Chun Li, Hiroshi Sato
Approximately three dozen Myxobolus spp. (Myxozoa: Myxosporea: Bivalvulida) have been described to parasitize the gills of carp of the genera Cyprinus and Carassius. Hitherto, these fish were often introduced to temperate waters worldwide as food and ornamental fish from Asia, their place of origin. The present study examined the myxosporean infection of seven common carp (Cyprinus carpio) and seven Japanese silver crucian carp (Carassius langsdorfii) collected from the Fushinogawa River around the university in Yamaguchi City, Japan, during the period April 2015 to October 2016...
July 5, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28674272/frequent-generation-of-mutants-with-coincidental-changes-in-multiple-traits-via-ion-beam-irradiation-in-soybean
#18
Shun Mikuriya, Megumi Kasai, Kenta Nakashima, Natasia, Yoshihiro Hase, Tetsuya Yamada, Jun Abe, Akira Kanazawa
Ion beams are powerful mutagens that can induce novel mutants in plants. We previously established a system for producing a mutant population of soybean via ion-beam irradiation, isolated plants that had chlorophyll deficiency, and maintained their progeny via self-fertilization. Here we report the characterization of the progeny plants in terms of chlorophyll content, flowering time and isoflavone content in seeds. Chlorophyll deficiency in the leaf tissues was linked with reduced levels of isoflavones, the major flavonoid compounds accumulated in soybean seeds, which suggested the involvement of metabolic changes associated with the chlorophyll deficiency...
June 30, 2017: Genes & Genetic Systems
https://www.readbyqxmd.com/read/28673192/association-between-clinicopathological-factors-and-genomic-abnormalities-detected-by-fish-analysis-in-epithelioid-diffuse-malignant-pleural-mesothelioma
#19
Maiko Takeda, Takahiko Kasai, Kinta Hatakeyama, Tokiko Nakai, Hiroe Itami, Tomoko Uchiyama, Norishige IIzuka, Hiroshi Maruyama, Chiho Ohbayashi
BACKGROUND: Abnormality of genes including 9p21 is known in malignant mesothelioma and we have examined the frequency of gene deletion and amplification using the fluorescence in situ hybridization (FISH) method. We formerly reported that abnormality of the genes was more common in the sarcomatoid type than epithelioid type. In this study, we compared the clinicopathological factors including nuclear grade (NG) and genomic abnormality in epithelioid malignant pleural mesothelioma (MPM)...
June 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28673141/a-case-of-chondrosarcoma-originating-from-the-pulmonary-artery
#20
Kenji Sakakibara, Hiroyuki Nakajima, Kazunari Kasai
No abstract text is available yet for this article.
June 2017: Asian Cardiovascular & Thoracic Annals
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