keyword
MENU ▼
Read by QxMD icon Read
search

Kasai

keyword
https://www.readbyqxmd.com/read/27923630/association-of-glycated-albumin-to-hba1c-ratio-with-diabetic-retinopathy-but-not-diabetic-nephropathy-in-patients-with-type-2-diabetes
#1
Yutaka Umayahara, Yohei Fujita, Hirotaka Watanabe, Noriko Kasai, Noritaka Fujiki, Masahiro Hatazaki, Masafumi Koga
OBJECTIVES: The ratio of glycated albumin to HbA1c (GA/HbA1c ratio) is a known indicator that reflects fluctuations in plasma glucose. In this study, the association of the GA/HbA1c ratio to diabetic nephropathy and diabetic retinopathy in patients with type 2 diabetes was investigated. DESIGN AND METHODS: Among patients with type 2 diabetes, 613 patients (364 males and 249 females, aged 63.2±12.5, body mass index (BMI) 25.4±4.8kg/m(2)) were enrolled. Patients with overt proteinuria, reduced renal function, or anemia were excluded...
December 3, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27923051/electrophysiological-characteristics-of-human-ipsc-derived-cardiomyocytes-for-the-assessment-of-drug-induced-proarrhythmic-potential
#2
Wataru Yamamoto, Keiichi Asakura, Hiroyuki Ando, Tomohiko Taniguchi, Atsuko Ojima, Takaaki Uda, Tomoharu Osada, Seiji Hayashi, Chieko Kasai, Norimasa Miyamoto, Hiroyuki Tashibu, Takashi Yoshinaga, Daiju Yamazaki, Atsushi Sugiyama, Yasunari Kanda, Kohei Sawada, Yuko Sekino
The aims of this study were to (1) characterize basic electrophysiological elements of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) that correspond to clinical properties such as QT-RR relationship, (2) determine the applicability of QT correction and analysis methods, and (3) determine if and how these in-vitro parameters could be used in risk assessment for adverse drug-induced effects such as Torsades de pointes (TdP). Field potential recordings were obtained from commercially available hiPSC-CMs using multi-electrode array (MEA) platform with and without ion channel antagonists in the recording solution...
2016: PloS One
https://www.readbyqxmd.com/read/27920667/double-in-situ-hybridization-for-micrornas-and-mrnas-in-brain-tissues
#3
Atsushi Kasai, Sora Kakihara, Hiroki Miura, Ryo Okada, Atsuko Hayata-Takano, Keisuke Hazama, Misaki Niu, Norihito Shintani, Takanobu Nakazawa, Hitoshi Hashimoto
MicroRNAs (miRNAs) participate in a variety of functions in the brain. Understanding the in vivo localization of miRNAs is an important step for uncovering their roles in brain function. However, the in situ detection of low-abundance miRNAs in brain tissues remains difficult and requires extensive optimization of in situ hybridization (ISH) protocols in individual laboratories. Thus, detailed information regarding experimental conditions would serve as a useful reference for researchers in this field. Here, we investigated and summarized the effects of adjusting a series of critical steps, including tissue fixation, probe accessibility and hybridization stringency, to standardize the currently used miRNA ISH procedures...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27889230/anticancer-effects-of-novel-thalidomide-analogs-in-a549-cells-through-inhibition-of-vascular-endothelial-growth-factor-and-matrix-metalloproteinase-2
#4
Bishoy El-Aarag, Tomonari Kasai, Junko Masuda, Hussein Agwa, Magdy Zahran, Masaharu Seno
Lung cancer is one of the major causes of cancer-related mortality worldwide, and non-small-cell lung cancer is the most common form of lung cancer. Several studies had shown that thalidomide has potential for prevention and therapy of cancer. Therefore, the current study aimed to investigate the antitumor effects of two novel thalidomide analogs in human lung cancer A549 cells. The antiproliferative, antimigratory, and apoptotic effects in A549 cells induced by thalidomide analogs were examined. In addition, their effects on the expression of mRNAs encoding vascular endothelial growth factor165 (VEGF165) and matrix metalloproteinase-2 (MMP-2) were evaluated...
November 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27886416/a-case-of-solitary-well-differentiated-papillary-mesothelioma-with-invasive-foci-in-the-pleura
#5
Shigeki Shimizu, Hyung-Eun Yoon, Norimasa Ito, Taisuke Tsuji, Yasunobu Funakoshi, Tomoki Utsumi, Masahiro Sakaguchi, Toru Tsujimura, Takahiko Kasai, Kenzo Hiroshima, Akihide Matsumura
Well-differentiated papillary mesothelioma (WDPM) is a rare, distinct tumor consisting of mesothelial cells with a papillary architecture, bland cytological features, and a tendency toward superficial spread without invasion. Rare cases with superficial invasion are termed WDPM with invasive foci. We report a case of solitary WDPM with invasive foci in the pleura. A 61-year-old woman presented with a lung adenocarcinoma. A small papillary lesion measuring 29 × 10 × 8 mm was incidentally found in the parietal pleura during a lobectomy for the lung adenocarcinoma...
November 25, 2016: Pathology International
https://www.readbyqxmd.com/read/27869277/a-chemical-proteomic-probe-for-detecting-native-carrier-protein-motifs-in-nonribosomal-peptide-synthetases
#6
Shota Kasai, Fumihiro Ishikawa, Takehiro Suzuki, Naoshi Dohmae, Hideaki Kakeya
Derivatization of a 5'-(vinylsulfonylaminodeoxy)adenosine scaffold with a clickable functionality provided an activity-based probe that was used to label native carrier protein (CP) motifs in nonribosomal peptide synthetases (NRPSs). When coupled with a fluorescent tag, this probe selectively targeted phosphopantetheinylated CPs (holo-form) from recombinant NRPS enzyme systems and in whole proteomes.
December 1, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27867941/familial-influences-on-mismatch-negativity-and-its-association-with-plasma-glutamate-level-a-magnetoencephalographic-study-in-twins
#7
Yukika Nishimura, Yuki Kawakubo, Motomu Suga, Kenji Hashimoto, Yuichi Takei, Kunio Takei, Hideyuki Inoue, Masato Yumoto, Ryu Takizawa, Kiyoto Kasai
Mismatch negativity (MMN) or its magnetic counterpart (magnetic mismatch negativity; MMNm) is regarded as a promising biomarker for schizophrenia. Previous electroencephalographic studies of MMN have demonstrated a moderate-to-high heritability for MMN amplitudes. N-methyl-D-aspartate receptor-dependent glutamatergic neurotransmission is implicated in MMN generation. We hypothesized that the differences between identical twins in MMNm variables might be associated with differences in plasma levels of amino acids involved in glutamatergic neurotransmission...
October 2016: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/27867158/preprocedural-high-sensitivity-c-reactive-protein-predicts-long-term-outcome-of-percutaneous-coronary-intervention
#8
Hideki Wada, Tomotaka Dohi, Katsumi Miyauchi, Jun Shitara, Hirohisa Endo, Shinichiro Doi, Ryo Naito, Hirokazu Konishi, Shuta Tsuboi, Manabu Ogita, Takatoshi Kasai, Ahmed Hassan, Shinya Okazaki, Kikuo Isoda, Kazunori Shimada, Satoru Suwa, Hiroyuki Daida
BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) has been used to predict the risk of adverse cardiac events in patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI). Less is known, however, about the association between hs-CRP and long-term outcome after PCI in the Japanese population.Methods and Results:We studied 3,039 all-comer patients with CAD who underwent their first PCI and had data available for preprocedural hs-CRP at Juntendo University between 2000 and 2011...
November 19, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27862693/gli1-a-master-regulator-of-the-hallmark-of-pancreatic-cancer
#9
REVIEW
Kenji Kasai
Hedgehog signaling is highly conserved across species and governs proper embryonic development. Germline gene mutations that reduce this signaling activity cause a variety of developmental abnormalities such as holoprosencephaly, while those that enhance Hedgehog signaling activity induce a tumor-predisposition condition Nevoid basal cell carcinoma syndrome. Furthermore, dysregulated activation of Hedgehog signaling has been recognized in various sporadic malignancies, including pancreatic adenocarcinoma. Pancreatic adenocarcinoma develops through a multistep carcinogenesis starting with oncogenic mutation of the KRAS gene...
December 2016: Pathology International
https://www.readbyqxmd.com/read/27859955/seventeen-years-of-kasai-portoenterostomy-for-biliary-atresia-in-a-single-southeast-asian-paediatric-centre
#10
Li Wei Chiang, Chuan Yaw Lee, Gita Krishnaswamy, Shireen Anne Nah, Ajmal Kader, Christina Ong, Yee Low, Kong Boo Phua
AIM: Biliary atresia (BA) has preponderance in Asian populations with Kasai portoenterostomy (KP) regarded as the first-line standard of care. Yet reports from Southeast Asia remain scant. This study reviews the demographics, short- and medium-term outcomes for our cohort, and evaluates prognostic factors for outcome. METHODS: All patients diagnosed with BA between January 1997 and December 2013 were included. Clinical data were obtained from medical records. Jaundice clearance was defined as total bilirubin < 20 µmol/L within 6 months after KP...
November 8, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27844419/incorrect-strain-information-for-mouse-cell-lines-sequential-influence-of-misidentification-on-sublines
#11
Kozue Uchio-Yamada, Fumio Kasai, Midori Ozawa, Arihiro Kohara
Misidentification or cross-contamination of cell lines can cause serious issues. Human cell lines have been authenticated by short tandem repeat profiling; however, mouse cell lines have not been adequately assessed. In this study, mouse cell lines registered with the JCRB cell bank were examined by simple sequence length polymorphism (SSLP) analysis to identify their strains. Based on comparisons with 7 major inbred strains, our results revealed their strains in 80 of 90 cell lines. However, 12 of the 80 cell lines (15%) were found to differ from registered information...
November 14, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/27830578/adjuvant-steroid-treatment-following-kasai-portoenterostomy-and-clinical-outcomes-of-biliary-atresia-patients-an-updated-meta-analysis
#12
Min-Zhong Zhang, Peng-Cheng Xun, Ka He, Wei Cai
BACKGROUND: It is controversial whether adjuvant steroid treatment should be given to biliary atresia (BA) patients following a Kasai portoenterostomy (KPE). This study aimed to quantitatively and systematically evaluate the effect of adjuvant steroid therapy post-KPE in relation to major clinical outcomes of BA patients. METHODS: We systematically reviewed the literature in PubMed, Embase, the Cochrane Library, China Knowledge Resource Integrated Database, Wanfang Database, Scholarly and Academic Information Navigator and manually searched for relevant papers published before August, 2015...
November 3, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27829461/gender-difference-in-preference-of-specialty-as-a-career-choice-among-japanese-medical-students
#13
Ryuichi Kawamoto, Daisuke Ninomiya, Yoshihisa Kasai, Tomo Kusunoki, Nobuyuki Ohtsuka, Teru Kumagi, Masanori Abe
BACKGROUND: In Japan, the absolute deficiency of doctors and maldistribution of doctors by specialty is a significant problem in the Japanese health care system. The purpose of this study was to investigate the factors contributing to specialty preference in career choice among Japanese medical students. METHODS: A total of 368 medical students completed the survey giving an 88.2 % response rate. The subjects comprised 141 women aged 21 ± 3 (range, 18-34) years and 227 men aged 22 ± 4 (range, 18-44) years...
November 10, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27828160/1-55-%C3%AE-m-hydrogen-cyanide-optical-frequency-stabilized-and-10-ghz-repetition-rate-stabilized-mode-locked-fiber-laser
#14
Masato Yoshida, Kazuki Yoshida, Keisuke Kasai, Masataka Nakazawa
We describe a 1.55 μm hydrogen cyanide (HCN) optical frequency and repetition rate stabilized mode-locked fiber laser, where the optical frequency was locked to the P(10) HCN absorption line and the repetition rate was locked to 9.95328 GHz by using a microwave phase-locked loop. The optical frequency stability of the laser reached 5 x 10<sup>-11</sup> with an integration time τ of 1 s. With a bidirectional pumping scheme, the laser output power reached 64.6 mW. To obtain a short pulse train, the average dispersion in the cavity was managed so that it was zero around 1...
October 17, 2016: Optics Express
https://www.readbyqxmd.com/read/27825275/magnetic-resonance-imaging-of-bone-marrow-for-tafro-syndrome
#15
Gen Nakamura, Noriyuki Homma, Akio Kasai, Takuya Kasami, Kunihiko Makino, Youhei Aoki, Kunihiko Wakaki, Norihito Nakagawa
We report two cases of TAFRO syndrome, which is characterized by thrombocytopenia, anasarca, fever, renal insufficiency, and organomegaly. Magnetic resonance imaging (MRI) of the spine showed a dark medullary pattern in the bone marrow on the T1- and T2-weighted images of both patients. One patient showed complete resolution after treatment. Serial MRIs of the improved patient revealed a transition to a normal marrow pattern on both images, which might represent resolution of the disease.
November 9, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27809998/brain-minds-a-japanese-national-brain-project-for-marmoset-neuroscience
#16
Hideyuki Okano, Erika Sasaki, Tetsuo Yamamori, Atsushi Iriki, Tomomi Shimogori, Yoko Yamaguchi, Kiyoto Kasai, Atsushi Miyawaki
Brain/MINDS (Brain Mapping by Integrated Neurotechnologies for Disease Studies) is a national brain project started by Japan in 2014. With the goal of developing the common marmoset as a model animal for neuroscience, the project aims to build a multiscale marmoset brain map, develop new technologies for experimentalists, create transgenic lines for brain disease modeling, and integrate translational findings from the clinical biomarker landscape. Brain/MINDS will collaborate with global brain projects to share technologies and resources...
November 2, 2016: Neuron
https://www.readbyqxmd.com/read/27805449/biomechanical-assessment-of-the-effects-of-vertebral-distraction-fusion-techniques-on-the-adjacent-segment-of-canine-cervical-vertebrae
#17
Takaharu Hakozaki, Tomu Ichinohe, Nobuo Kanno, Takuya Yogo, Yasuji Harada, Tadashi Inaba, Yuichi Kasai, Yasushi Hara
OBJECTIVE To assess effects of vertebral distraction-fusion techniques at a treated segment (C5-C6) and an adjacent segment (C4-C5) of canine cervical vertebrae. SAMPLE Cervical vertebrae harvested from cadavers of 10 skeletally mature Beagles. PROCEDURES Three models (intact, titanium plate, and polymethylmethacrylate [PM MA]) for stabilization of the caudal region of the cervical vertebrae (C4 through C7) were applied to the C5-C6 vertebral segment sequentially on the same specimens. Biomechanical assessments with flexion-extension, lateral bending, and axial rotational tests were conducted after each procedure...
November 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27804186/estimated-cognitive-decline-in-patients-with-schizophrenia-a-multi-center-study
#18
Haruo Fujino, Chika Sumiyoshi, Yuka Yasuda, Hidenaga Yamamori, Michiko Fujimoto, Masaki Fukunaga, Kenichiro Miura, Yuto Takebayashi, Naohiro Okada, Shuichi Isomura, Naoko Kawano, Atsuhito Toyomaki, Hironori Kuga, Masanori Isobe, Kazuto Oya, Yuko Okahisa, Manabu Takaki, Naoki Hashimoto, Masaki Kato, Toshiaki Onitsuka, Takefumi Ueno, Tohru Ohnuma, Kiyoto Kasai, Norio Ozaki, Tomiki Sumiyoshi, Osamu Imura, Ryota Hashimoto
AIM: Studies have reported that cognitive decline occurs after the onset of schizophrenia despite heterogeneity in cognitive function among patients. The aim of this study was to investigate the degree of estimated cognitive decline in patients with schizophrenia by comparing estimated premorbid intellectual functioning and current intellectual functioning. METHODS: A total of 446 patients with schizophrenia (228 male, 218 female), consisting of three sample sets obtained from 11 psychiatric facilities, and 686 healthy controls participated in this study...
October 31, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27803603/serum-carcinoembryonic-antigen-as-a-tumour-marker-in-patients-with-endometrial-cancer
#19
Y Hashiguchi, M Kasai, T Fukuda, T Ichimura, T Yasui, T Sumi
BACKGROUND: No potential tumour markers have been validated for prognosis in endometrial cancer. However, carcinoembryonic antigen (cea) is one of the most widely used tumour markers in various types of cancer. Although cea expression in endometrial cancer has been investigated, its prognostic value remains controversial, and no studies have investigated serum cea levels in large case series. In the present study, we investigated diagnostic and prognostic applications of serum cea for endometrial cancer...
October 2016: Current Oncology
https://www.readbyqxmd.com/read/27803486/efforts-by-pharmacists-in-community-pharmacy-in-peacetime-for-headache-medical-care-in-emergencies-such-as-great-earthquake-and-disaster
#20
Masakazu Ishii, Hirotaka Katoh, Masaaki Ishibashi, Mizuki Ichikawa, Shinji Kurokawa, Setsuro Tsukada, Hideyo Kasai, Yuji Kiuchi, Sanju Iwamoto
 We herein analyzed the issues that pharmacists in a community pharmacy in peacetime need to prepare for regarding headache medical care in emergencies (the state that supply of medical supplies is difficult) using a questionnaire intended for doctors and pharmacists in a community pharmacy. Recovery rates were 48.0% (96/200) for doctors and 37.3% (112/300) for pharmacists. In order to distinguish between patients for whom pharmacists need to "recommend OTC drugs" and those who need to be encouraged "to consult a hospital or clinic", doctors indicated that pharmacists need to use an "assistance tool to diagnosis headaches, such as a migraine screener" and "guidelines for chronic headaches"...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
keyword
keyword
102140
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"