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https://www.readbyqxmd.com/read/28729019/safety-reactogenicity-and-immunogenicity-of-two-investigational-pneumococcal-protein-based-vaccines-results-from-a-randomized-phase-ii-study-in-infants
#1
Roman Prymula, Leszek Szenborn, Sven-Arne Silfverdal, Jacek Wysocki, Piotr Albrecht, Magali Traskine, Asparuh Gardev, Yue Song, Dorota Borys
INTRODUCTION: Vaccination with formulations containing pneumococcal protein antigens such as pneumolysin toxoid (dPly) and histidine-triad protein D (PhtD) may extend serotype-related protection of pneumococcal conjugate vaccines (PCVs) against Streptococcus pneumoniae. METHODS: This phase II, multi-center, observer-blind trial conducted in Europe (NCT01204658) assessed 2 investigational vaccines containing 10 serotype-specific polysaccharide conjugates of PHiD-CV and either 10 or 30µg of dPly and PhtD each...
July 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28705230/changes-in-hepatitis-b-virus-antibody-titers-over-time-among-children-a-single-center-study-from-2012-to-2015-in-an-urban-of-south-korea
#2
Kyeong Hun Lee, Kyu Seok Shim, In Seok Lim, Soo Ahn Chae, Sin Weon Yun, Na Mi Lee, Young Bae Choi, Dae Yong Yi
BACKGROUND: Hepatitis B virus (HBV) infection is the most common cause of liver disease in endemic areas such as South Korea. After HBV vaccination, hepatitis B surface antibody (HBsAb) titers gradually decrease. Trends in HBsAb titers have not been evaluated among children in South Korea over the past decade. METHODS: We screened 6155 patients (aged 7 months to 17 years) who underwent HBV antigen/antibody testing at Chung-Ang University Hospital from May 2012 to April 2015...
July 14, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28696824/age-appropriate-versus-up-to-date-coverage-of-routine-childhood-vaccinations-among-young-children-in-israel
#3
Chen Stein-Zamir, Avi Israeli
BACKGROUND AND AIMS: Routine childhood vaccinations schedules recommend that children receive the vaccine doses at specific ages. Vaccination coverage data are conventionally reported by the up-to-date method. We aimed to assess vaccination timeliness by the age-appropriate method and compare to the up-to-date vaccination coverage. METHODS: Assessment of age-appropriate and up-to-date vaccination coverage among children born in Israel in 2009 and followed to age 48 months (national representative sample, n = 3892)...
July 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28693080/-the-epidemiological-characteristics-of-hbv-susceptibility-in-1-29-years-old-young-people-in-china-in-2006-and-2014-based-on-the-national-sero-survey-data-analysis
#4
H Zheng, F Z Wang, G M Zhang, N Miao, X J Sun, F Q Cui
Objective: To analyze the epidemiological characteristics of HBV susceptible people in 1-29 years old people in 2006 and 2014 in China. Method: Data is from the 2006 and 2014 national sero-survey, and both of them were conducted in 160 disease surveillance points of 31 provinces (excluding Hong Kong, Macao Special Administrative Region and Taiwan province) in China. We used the centralized face-to face investigation method to collect basic information including birth date, gender, ethnicity, resident place, hepatitis B vaccination (HepB) history and so on, and 5 ml venous blood was collected for all subjects to test the sero-markers of HBsAg, anti-HBs and anti-HBc...
July 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28675359/the-romanian-national-program-for-liver-transplantation-852-procedures-in-815-patients-over-17-years-2000-2017-a-continuous-evolution-to-success
#5
Irinel Popescu, Mihnea Ionescu, Vladislav Braşoveanu, Doina Hrehoreţ, Narcis Copca, Cristian Lupaşcu, Florin Botea, Bogdan Dorobanţu, Sorin Alexandrescu, Mihai Grigorie, Emil Matei, Radu Zamfir, Vasile Lungu, Dana Tomescu, Gabriela Droc, Daniela Ungureanu, Ruxandra Fota, Graţiela Manga, Mihai Popescu, Laura Popa, Liana Gheorghe, Speranţa Iacob, Corina Pietrăreanu, Mariana Mihailă, Laurenţiu Mic, Sanda Constantinescu, Cristian Gheorghe, Bogdan Cotruta, Ioana Lupescu, Mugur Grasu, Mirela Boroş, Radu Dumitru, Mihai Toma, Liliana Paslaru, Laura Vlad, Ileana Constantinescu, Ileana Dima, Vlad Herlea, Gabriel Becheanu, Cătălin Pecheanu, Daniela Sasalovici
Background: Liver transplantation (LT) has become an established treatment for end-stage liver disease, with more than 20.000 procedures yearly worldwide. The aim of this study was to analyze the results of Romanian National Program of LT. Methods: Between April 2000 and April 2017, 817 pts received 852 LTs in Romania. Male/female ratio was 487/330, while adult/pediatric ratio was 753/64, with a mean age of 46 years (median 50 yrs; range 7 months - 68 yrs). Main LT indications were HBV cirrhosis (230 pts; 28...
May 2017: Chirurgia
https://www.readbyqxmd.com/read/28673589/hepatitis-b-vaccine-non-response-a-predictor-of-latent-autoimmunity
#6
M D Raffaella Mormile
Unresponsiveness to Hepatitis B virus (HBV) vaccine has been associated with interleukins involved with Th1 functioning including Interleukin-8 (IL-18) and Interferon-γ (IFN-γ). IL-18 and IFN-γ have also been implicated in the onset of different types of immune-mediate inflammatory conditions such as Type 1 Diabetes (T1D), Celiac disease (CD), rheumatoid arthritis (RA), obesity and systemic lupus erythematosus (SLE). Taking into account that HBV vaccination is provided in the 1st year of life worldwide, I propose that all babies should be tested for anti-HBs response after completion of the vaccine series...
July 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28666469/on-the-implications-of-desexualizing-vaccines-against-sexually-transmitted-diseases-health-policy-challenges-in-a-multicultural-society
#7
Baruch Velan, Yaacov Yadgar
Two vaccines against sexually transmitted infections are included in many national vaccination programs: Hepatitis B Virus (HBV) vaccine and Human Papilloma Virus (HPV) vaccine. The trajectories of the implementation of these two programs were marked by differences in the way the sexual context of risk was communicated to the public. These trajectories fluctuated between full accounts of the sexual nature of the infection and attempts to desexualize the vaccines. Vaccine desexualization can be achieved by withholding information of sexual context, blurring information, and distancing the age of vaccination from the age of sexual debut...
July 1, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28664713/predictors-of-hepatitis-b-surface-antigen-titers-two-decades-after-vaccination-in-a-cohort-of-students-and-post-graduates-of-the-medical-school-at-the-university-of-palermo-italy
#8
M G Verso, N Lo Cascio, E Noto Laddeca, E Amodio, M Currieri, G Giammanco, D Ferraro, S De Grazia, D Picciotto
<b>Introduction and objective.</b> The introduction of a vaccine against hepatitis B virus (HBV) for newborn babies in Italy in 1991, extended to 12-year-old children for the first 12 years of application, has been a major achievement in terms of the prevention of HBV infection. The objective of this study was to analyse the long-term immunogenicity and effectiveness of HBV vaccination among healthcare students with different working seniorities. <b>Materials and method.</b> A cross-sectional observational study of undergraduate and postgraduate students attending the Medical School of the University of Palermo was conducted from January 2014 - July 2016...
June 12, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28660149/mechanisms-and-prevention-of-vertical-transmission-in-chronic-viral-hepatitis
#9
REVIEW
Marianna G Mavilia, George Y Wu
Vertical transmission (VT) is the primary route of transmission of viral hepatitis in children. The rate of VT ranges from 1-28% with hepatitis B virus (HBV) and 3-15% with hepatitis C virus (HCV). VT for both viruses can occur during the intrauterine or peripartum period. VT of HBV primarily occurs by intrauterine transmission (IUT). Hepatitis B surface antigen is unable to cross the placenta and, therefore, relies on processes like transplacental leakage, placental infection, cellular transmission by peripheral blood mononuclear cells, and germline transmission...
June 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28658511/occult-hepatitis-b-virus-infection-in-immunized-children-born-to-carrier-mothers
#10
Koji Yokoyama, Hideki Kumagai, Masaharu Takahashi, Shigeo Nagashima, Hiroaki Okamoto, Takanori Yamagata
BACKGROUND: The prevalence of occult hepatitis B virus (HBV) infection (OBI) in children who develop the infection via mother-to-child transmission (MTCT) despite immunoprophylaxis remains controversial and is still unknown in Japan. The aim of this study was to determine the OBI prevalence among such children in Japan and identify the genomic mutations that might be associated with the pathogenesis of OBI in children. METHODS: The data on 158 children born to HBV carrier mothers and who received complete passive-active immunoprophylaxis after birth 2002-2014 were reviewed...
June 28, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28639095/knowledge-awareness-and-prevention-of-hepatitis-b-virus-infection-among-korean-american-parents
#11
Sarah Hyun, Seulgi Lee, William R Ventura, Joseph McMenamin
Hepatitis B (HB) affects 240 million people around the world, and children and young adults make up a large proportion of the infected population. Approximately 1 million people die from HB each year. Despite the seriousness of HB and its complications, many are poorly linked to clinical care. A lack of health literacy may be a critical barrier hindering access to HB care for adults as well as children in these populations. We, therefore, performed a survey to assess the level of knowledge of HB among Korean American parents...
June 21, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28612569/-negative-hbsag-and-hbsab-in-women-of-child-bearing-age-in-mianyang
#12
Xiao-Hua Wen, Chuan Xiao, Min Wang, Lan Wang, Juan Wang, Tao Ren, Li-Ping Wang, Shu-Wen Cheng, Xuan Zhang, Wen-Hao Zhang, Ping Yuan
OBJECTIVES: To investigate the distribution of women with negative HBsAg and HBsAb at child-bearing age in Mianyang. METHODS: A total of 62 551 women aged 15-49 yr. were selected randomly using a multistage sampling strategy in Mianyang to participate in a questionnaire survey. Blood samples were collected during the survey. HBsAg and HBsAb were detected by enzyme-linked immunosorbent assay (ELISA). Those who were both HBsAg and HBsAb negative were deemed as susceptible to future infection of HBV...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28592092/-early-physical-growth-and-disease-analysis-among-children-born-delivered-by-hbsag-positive-mothers
#13
X H Zhang, Q Wang, W Zheng, X H Li, Q Q Jiang, C F Zhou, L Q Qiu
Objective: To estimate the early physical growth and disease in children born to HBsAg-positive mothers. Methods: This was a retrospective cohort study. Three areas as Xihu in Hangzhou, Lanxi in Jinhua, and Haiyan in Jiaxing in Zhejiang province were selected by cluster sampling. The growth outcomes of children born to HBsAg-positive mothers (exposure group) and matched 1∶1 women uninfected with HBV (control group) in 2014 were investigated and compared at birth, 6, 9, 12, and 18 months, respectively. There were totally 342 children in each group...
June 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28586593/immune-response-and-anamnestic-immune-response-in-children-after-a-3-dose-primary-hepatitis-b-vaccination
#14
Muhammad Faheem Afzal, Muhammad Ashraf Sultan, Ahmad Imran Saleemi
BACKGROUND: Diseases caused by Hepatitis B virus (HBV) have a worldwide distribution. Pakistan adopted the recommendations of World Health Organization (WHO) for routine universal infant vaccination against hepatitis B in 2002, currently being administered at 6, 10, and 14 weeks of age in a combination vaccine. This study was conducted to determine the immune response & anamnestic immune response in children, 9 months-10 years of age, after a 3dose primary Hepatitis B vaccination. METHODS: This cross sectional study was conducted in the Department of Paediatrics, King Edward Medical University/Mayo Hospital, Lahore, Pakistan, from January to June, 2014...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28586278/the-immunogenicity-of-gsk-s-recombinant-hepatitis-b-vaccine-in-children-a-systematic-review-of-30-years-of-experience
#15
Caroline van den Ende, Cinzia Marano, Ayla van Ahee, Eveline M Bunge, Laurence De Moerlooze
The World Health Organization recommends hepatitis B virus (HBV) vaccines to be included in national immunization schedules everywhere, and has adopted the strategic goal of halting viral hepatitis as a major public health threat by 2030, under which vaccination plays a major role. Engerix™ B (GSK HepB, GSK, Belgium) was the first recombinant HBV vaccine to be licensed, and marked its 30th anniversary in 2016. Areas covered: We conducted a systematic review of the literature summarizing 30 years of immunogenicity and safety data for GSK HepB in children and adolescents...
August 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28543299/low-occurrence-of-hbsag-but-high-frequency-of-transient-occult-hbv-infection-in-vaccinated-and-hbig-administered-infants-born-to-hbsag-positive-mothers
#16
Shan Zhou, Tingting Li, Jean-Pierre Allain, Bin Zhou, Yuming Zhang, Mei Zhong, Yongshui Fu, Chengyao Li
The status of chronic and occult HBV infection (OBI) in neonatal hepatitis B vaccine and immunoglobulin (HBIG) vaccinated infants born to HBsAg+ mothers was investigated at a major hospital in China. Seventy-seven and 15 blood samples were collected in first or second follow-up detection from the vaccinated babies aged 3 to 36 months born to 43 HBsAg+ or plus 25 HBeAg+ mothers. HBV infection was analyzed between the paired baby and mother by serology and DNA analysis. Among 77 children born to 68 HBsAg+ mothers, 3...
May 23, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28497124/parv4-prevalence-phylogeny-immunology-and-coinfection-with-hiv-hbv-and-hcv-in-a-multicentre-african-cohort
#17
Colin P Sharp, William F Gregory, Louise Hattingh, Amna Malik, Emily Adland, Samantha Daniels, Anriette van Zyl, Jonathan M Carlson, Susan Wareing, Anthony Ogwu, Roger Shapiro, Lynn Riddell, Fabian Chen, Thumbi Ndung'u, Philip J R Goulder, Paul Klenerman, Peter Simmonds, Pieter Jooste, Philippa C Matthews
Background: The seroprevalence of human parvovirus-4 (PARV4) varies considerably by region. In sub-Saharan Africa, seroprevalence is high in the general population, but little is known about the transmission routes or the prevalence of coinfection with blood-borne viruses, HBV, HCV and HIV.  Methods: To further explore the characteristics of PARV4 in this setting, with a particular focus on the prevalence and significance of coinfection, we screened a cohort of 695 individuals recruited from Durban and Kimberley (South Africa) and Gaborone (Botswana) for PARV4 IgG and DNA, as well as documenting HIV, HBV and HCV status...
April 7, 2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28492419/seroprevalence-of-antibodies-and-antigens-against-hepatitis-a-e-viruses-in-refugees-and-asylum-seekers-in-germany-in-2015
#18
Alexandra Jablonka, Philipp Solbach, Michael Wöbse, Michael P Manns, Reinhold E Schmidt, Heiner Wedemeyer, Markus Cornberg, Georg M N Behrens, Svenja Hardtke
BACKGROUND: Migration because of miscellaneous political crises in countries in the Middle East and Africa is a global challenge for whole Europe from an economic, social, and public health view. There is an urgent need to generate comprehensive, evidence-based data to expedite further screening and vaccination strategies. METHODS: A total of 604 individuals ranging in age from 2 to 68 years who enrolled at a single reception center were tested for the prevalence of serologic markers for hepatitis virus types A, B, C, D, and E (HAV, HBV, HCV, HDV, HEV), respectively...
August 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28483405/quasispecies-characteristics-in-mother-to-child-transmission-of-hepatitis%C3%A2-b%C3%A2-virus-by-next-generation-sequencing
#19
Guifeng Yang, Zhihua Liu, Juncheng Yang, Kangxian Luo, Ying Xu, Haitang He, Qunfang Fu, Shouyi Yu, Zhanhui Wang
OBJECTIVES: To identify within-host quasispecies characteristics of hepatitis B virus (HBV) in mothers and children infected via mother-to-child transmission (MTCT). METHODS: Using next-generation sequencing (NGS), we analyzed sequences within the non-overlapping pre-core/core (pre-C/C) gene in 37 mother-child pairs. RESULTS: Phylogenetic and Highlighter analyses suggested that both a single strain and multiple distinct strains may be transmitted in MTCT of HBV...
May 5, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28473203/time-to-re-evaluate-the-effect-of-the-adolescent-booster-of-hepatitis-b-vaccine
#20
EDITORIAL
Ellie Carmody
No abstract text is available yet for this article.
July 2017: International Journal of Infectious Diseases: IJID
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