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https://www.readbyqxmd.com/read/28222436/recurrent-angioedema-occurrence-features-and-concomitant-diseases-in-an-italian-single-center-study
#1
Paola Triggianese, Maria Domenica Guarino, Chiara Pellicano, Mauro Borzi, Elisabetta Greco, Stella Modica, Caterina De Carolis, Roberto Perricone
BACKGROUND: Angioedema (AE) is a potentially life-threatening condition with hereditary (HAE), acquired (AAE), or iatrogenic causes. A careful workup allows for the identification of the etiology of attacks and the appropriate management. In this cohort study, based on a clinical practice setting, we aimed at investigating clinical and laboratory findings concerning different features of patients with recurrent AE who were referred to a single, tertiary-level center for HAE. METHODS: Clinical and laboratory data of patients fulfilling the criteria for C1-inhibitor-deficient HAE (C1-INH-HAE), C1-INH-AAE, angiotensin-converting enzyme inhibitor-related AE (ACEI-RA), and idiopathic AAE (I-AAE) were evaluated...
February 22, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28212920/neonatal-lupus-follow-up-in-infants-with-anti-ssa-ro-antibodies-and-review-of-the-literature
#2
REVIEW
Antonio Alberto Zuppa, Riccardo Riccardi, Simonetta Frezza, Francesca Gallini, Rita Maria Paola Luciano, Giovanni Alighieri, Costantino Romagnoli, Sara De Carolis
Neonatal Lupus Syndrome (NLS) is a distinct clinical entity caused by transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have systemic lupus erythematosus, Sjögren syndrome, or other connective tissue disease, or may be completely healthy at the time of giving birth. NLS includes several clinical manifestations: complete congenital heart block (CCHB) and cutaneous lupus are the most common, while hepatobiliary disease, hematological manifestations and central nervous system involvement may occur...
February 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28202520/evolution-of-cancer-stem-like-cells-in-endocrine-resistant-metastatic-breast-cancers-is-mediated-by-stromal-microvesicles
#3
Pasquale Sansone, Marjan Berishaj, Vinagolu K Rajasekhar, Claudio Ceccarelli, Qing Chang, Antonio Strillacci, Claudia Savini, Lauren Shapiro, Robert Bowman, Chiara Mastroleo, Sabrina De Carolis, Laura Daly, Alberto Benito-Martin, Fabiana Perna, Nicola Fabbri, John H Healey, Enzo Spisni, Monica Cricca, David Lyden, Massimiliano Bonafé, Jacqueline Bromberg
The hypothesis that microvesicle (MV)-mediated microRNA transfer converts non-cancer stem cells into cancer stem cells (CSCs) leading to therapy resistance remains poorly investigated. Here we provide direct evidence supporting this hypothesis, by demonstrating how MV derived from cancer associated fibroblasts (CAF) transfer miR-221 to promote hormonal therapy resistance (HTR) in models of luminal breast cancer. We determined that CAF-derived MV horizontally transferred miR221 to tumor cells and, in combination with hormone therapy activated an ERlo/Notchhi feed-forward loop responsible for the generation of CD133hi CSC...
February 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28107787/hiv-rapid-testing-in-the-framework-of-an-sti-prevention-project-on-a-cohort-of-vulnerable-italians-and-immigrants
#4
Ilaria Uccella, Alessio Petrelli, Maria Fenicia Vescio, Silvia De Carolis, Cecilia Fazioli, Patrizio Pezzotti, Gianni Rezza
INTRODUCTION: Uptake of HIV tests is a challenging issue in vulnerable populations including immigrants, normally using standard diagnostic tools. Objectives of this study were to evaluate the acceptability of HIV rapid test; estimate the percentage of newly HIV diagnoses and evaluate knowledge, attitudes and perception (KAP) about HIV/AIDS and other STIs in a specific set of immigrants and vulnerable population in Rome (Italy). METHODS: All immigrant and Italian people, aged 16-70 years, attending the infectious disease outpatient clinic of the National Institute for Health, Migration and Poverty (INMP) in Rome (Italy), during the period December 2012 to December 2013 were enrolled...
January 20, 2017: AIDS Care
https://www.readbyqxmd.com/read/27858902/accessory-gallbladder-in-an-intrahepatic-location-mimicking-a-cystic-tumor-of-the-liver-a-case-report
#5
Ji-Hye Won, Seo-Youn Choi, Hae Kyung Lee, Boem Ha Yi, Min Hee Lee, Min Jung Jung
BACKGROUND: Double gallbladder (GB) is a rare congenital anomaly of the biliary system characterized by the presence of an accessory GB. CLINICAL FINDINGS: A 38-year-old female presented with a history of right upper quadrant (RUQ) pain. Computed tomography (CT) showed a lobulated cystic mass involving the center portion of liver. Magnetic resonance imaging (MRI) additionally revealed a tubular structure of T2 bright signal intensity (SI), which connected the cystic lesion of the liver to the bile duct...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27837519/molecular-detection-of-resistance-to-azole-components
#6
Brunella Posteraro, Antonietta Vella, Elena De Carolis, Maurizio Sanguinetti
Fungal infections have increased significantly in the last few years, and their outcomes are in part complicated by the emergence of antifungal drug-resistant pathogens. Together with Candida species, the mould Aspergillus fumigatus is one of the most prevalent organisms to cause invasive fungal disease. The molecular detection of (tri)azole resistance in both Candida and Aspergillus species may represent a useful means of monitoring the incidence of clinical isolates with antifungal resistance-associated gene alterations...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27837518/molecular-detection-of-resistance-to-echinocandins
#7
Brunella Posteraro, Antonietta Vella, Elena De Carolis, Maurizio Sanguinetti
In the last years, life-threatening fungal diseases have increased significantly, due to the rising number of human individuals susceptible to fungal infections, which are in part complicated by the emergence of antifungal drug-resistant pathogens. Among yeasts, Candida albicans and Candida glabrata are the most common organisms responsible for invasive fungal diseases. The molecular detection of echinocandin resistance in Candida species may represent a useful means of monitoring the incidence of clinical isolates with antifungal resistance-associated gene alterations...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27746440/recurrent-cholangitis-in-a-patient-with-autosomal-dominant-polycystic-kidney-disease-adpkd-and-caroli-s-disease
#8
Eiko Hasegawa, Naoki Sawa, Junichi Hoshino, Tatsuya Suwabe, Noriko Hayami, Masayuki Yamanouchi, Akinari Sekine, Rikako Hiramatsu, Aya Imafuku, Masahiro Kawada, Yoshifumi Ubara, Tsunao Imamura, Kenmei Takaichi
We herein present a rare case of an autosomal dominant polycystic kidney disease (ADPKD) patient with Caroli's disease, a congenital embryonic biliary tree ductal plate abnormality often associated with autosomal recessive polycystic kidney disease. A 76-year-old woman with ADPKD on hemodialysis was admitted to our hospital with recurrent cholangitis and hepatobiliary stones. Caroli's disease was diagnosed according to typical imaging findings of cystic intrahepatic bile duct dilatation and the central dot sign...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27668356/cortical-sources-of-resting-state-eeg-rhythms-are-related-to-brain-hypometabolism-in-subjects-with-alzheimer-s-disease-an-eeg-pet-study
#9
Claudio Babiloni, Claudio Del Percio, Anna Caroli, Elena Salvatore, Emanuele Nicolai, Nicola Marzano, Roberta Lizio, Enrica Cavedo, Susan Landau, Kewei Chen, William Jagust, Eric Reiman, Gioacchino Tedeschi, Patrizia Montella, Manuela De Stefano, Loreto Gesualdo, Giovanni B Frisoni, Andrea Soricelli
Cortical sources of resting state electroencephalographic (EEG) delta (2-4 Hz) and low-frequency alpha (8-10.5 Hz) rhythms show abnormal activity (i.e., current density) in patients with dementia due to Alzheimer's disease (AD). Here, we hypothesized that abnormality of this activity is related to relevant disease processes as revealed by cortical hypometabolism typically observed in AD patients by fluorodeoxyglucose positron emission tomography. Resting state eyes-closed EEG data were recorded in 19 AD patients with dementia and 40 healthy elderly (Nold) subjects...
December 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27658827/the-transition-from-intra-to-extra-uterine-life-in-late-preterm-infant-a-single-center-study
#10
M P De Carolis, G Pinna, C Cocca, S A Rubortone, C Romagnoli, I Bersani, S Salvi, A Lanzone, S De Carolis
BACKGROUND: Infants born at 34 to 36 weeks of gestation (late preterm) are at greater risk for adverse outcomes than those born at 37 weeks of gestation or later. Aim of this paper is to examine risk factors for late preterm births and to investigate the complications of the transition period in late preterm infants (LPIs). METHODS: All consecutive late preterm deliveries, excluded stillbirths, were included. Maternal and neonatal data, need for delivery room resuscitative procedures, temperature at birth (T1) and two hours after the admission (T2) were analyzed in all LPIs stratified by Gestational Age (GA) and divided into three groups (34, 35 and 36 weeks)...
September 22, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27367327/diagnosis-of-nocardia-paucivorans-central-nervous-system-infection-by-dna-sequencing-from-paraffin-embedded-tissue
#11
Elisabetta Schiaroli, Maria Bruna Pasticci, Elena De Carolis, Enrica Mello, Carlo Pallotto, Christian Leli, Giuseppe Vittorio De Socio, Franco Baldelli, Maurizio Sanguinetti, Antonella Mencacci
Infections by Nocardia spp. are generally regarded as opportunistic diseases in immunocompromised patients, but can also affect immunocompetent subjects. Such infections represent an important diagnostic challenge for clinicians and microbiologists, and diagnosis is frequently delayed or even conducted post mortem. A 54-year-old man was admitted to our hospital because of ventriculitis and relapsing brain abscess. Five months prior, this patient had undergone external ventricular drain and surgery for a cerebellar abscess...
June 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27354778/development-of-a-barthel-index-based-on-dyspnea-for-patients-with-respiratory-diseases
#12
Michele Vitacca, Mara Paneroni, Paola Baiardi, Vito De Carolis, Elisabetta Zampogna, Stefano Belli, Mauro Carone, Antonio Spanevello, Bruno Balbi, Giorgio Bertolotti
BACKGROUND: As Barthel Index (BI) quantifies motor impairment but not breathlessness, the use of only this index could underestimate disability in chronic respiratory disease (CRD). To our knowledge, no study evaluates both motor and respiratory disability in CRD during activities of daily living (ADLs) simultaneously and with a unique tool. The objective of this study was to propose for patients with CRD an additional tool for dyspnea assessment during ADLs based on BI items named Barthel Index dyspnea...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27258476/four-year-results-of-a-prospective-single-arm-study-on-200-semi-constrained-total-cervical-disc-prostheses-clinical-and-radiographic-outcome
#13
MULTICENTER STUDY
Hans-Jörg Meisel, Lubomír Jurák, Jussi Antinheimo, Ricardo Arregui, Bernhard Bruchmann, Mario Čabraja, Fabrizio Caroli, Stefan Kroppenstedt, Jan Kryl, Juha Pohjola, Ian Shackleford, Steffen Sola, Peter Stosberg, Jan Stulik, Christian Woiciechowsky, Petr Suchomel
OBJECTIVE Recent studies have described encouraging outcomes after cervical total disc replacement (cTDR), but there are also critical debates regarding the long-term effects of heterotopic ossification (HO) and the prevalence of adjacent-level degeneration. The aim in this paper was to provide 4-year clinical and radiographic outcome results on the activ C disc prosthesis. METHODS A total of 200 subjects underwent single-level activ C (Aesculap AG) implantation between C-3 and C-7 for the treatment of symptomatic degenerative disc disease...
November 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27236861/prognostic-value-of-preoperative-von-willebrand-factor-plasma-levels-in-patients-with-glioblastoma
#14
Giovanni Marfia, Stefania Elena Navone, Claudia Fanizzi, Silvia Tabano, Chiara Pesenti, Loubna Abdel Hadi, Andrea Franzini, Manuela Caroli, Monica Miozzo, Laura Riboni, Paolo Rampini, Rolando Campanella
Circulating biomarker for malignant gliomas could improve both differential diagnosis and clinical management of brain tumor patients. Among all gliomas, glioblastoma (GBM) is considered the most hypervascularized tumor with activation of multiple proangiogenic signaling pathways that enhance tumor growth. To investigate whether preoperative antigen plasma level of von Willebrand Factor (VWF:Ag) might be possible marker for GBM onset, progression, and prognosis, we retrospectively examined 57 patients with histological diagnosis for GBM and 23 meningiomas (MNGs), benign intracranial expansive lesions, enrolled as controls...
August 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27108670/innate-immune-system-at-the-maternal-fetal-interface-mechanisms-of-disease-and-targets-of-therapy-in-pregnancy-syndromes
#15
REVIEW
Paola Triggianese, Carlo Perricone, Maria Sole Chimenti, Caterina De Carolis, Roberto Perricone
The maternal-fetal interface is an immunologically unique site that allows the tolerance to the allogenic fetus and maintains host defense against possible pathogens. Balanced immune responses are required for the maintenance of successful pregnancy. It has been demonstrated that innate immune disturbances may be responsible for some adverse pregnancy outcomes such as preeclampsia (PE); hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome; intrauterine growth restriction (IUGR); and recurrent spontaneous abortion (RSA)...
October 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/26943583/anti-tnf-%C3%AE-treatment-modulates-sasp-and-sasp-related-micrornas-in-endothelial-cells-and-in-circulating-angiogenic-cells
#16
Francesco Prattichizzo, Angelica Giuliani, Rina Recchioni, Massimiliano Bonafè, Fiorella Marcheselli, Sabrina De Carolis, Anna Campanati, Katia Giuliodori, Maria Rita Rippo, Francesca Brugè, Luca Tiano, Carla Micucci, Antonio Ceriello, Annamaria Offidani, Antonio Domenico Procopio, Fabiola Olivieri
Endothelial cell senescence is characterized by acquisition of senescence-associated secretory phenotype (SASP), able to promote inflammaging and cancer progression. Emerging evidence suggest that preventing SASP development could help to slow the rate of aging and the progression of age-related diseases, including cancer. Aim of this study was to evaluate whether and how adalimumab, a monoclonal antibody directed against tumor necrosis factor-α (TNF-α), a major SASP component, can prevent the SASP. A three-pronged approach has been adopted to assess the if adalimumab is able to: i) modulate a panel of classic and novel senescence- and SASP-associated markers (interleukin [IL]-6, senescence associated-β-galactosidase, p16/Ink4a, plasminogen activator inhibitor 1, endothelial nitric oxide synthase, miR-146a-5p/Irak1 and miR-126-3p/Spred1) in human umbilical vein endothelial cells (HUVECs); ii) reduce the paracrine effects of senescent HUVECs' secretome on MCF-7 breast cancer cells, through wound healing and mammosphere assay; and iii) exert significant decrease of miR-146a-5p and increase of miR-126-3p in circulating angiogenic cells (CACs) from psoriasis patients receiving adalimumab in monotherapy...
March 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/26912555/effect-of-sirolimus-on-disease-progression-in-patients-with-autosomal-dominant-polycystic-kidney-disease-and-ckd-stages-3b-4
#17
Piero Ruggenenti, Giorgio Gentile, Norberto Perico, Annalisa Perna, Luca Barcella, Matias Trillini, Monica Cortinovis, Claudia Patricia Ferrer Siles, Jorge Arturo Reyes Loaeza, Maria Carolina Aparicio, Giorgio Fasolini, Flavio Gaspari, Davide Martinetti, Fabiola Carrara, Nadia Rubis, Silvia Prandini, Anna Caroli, Kanishka Sharma, Luca Antiga, Andrea Remuzzi, Giuseppe Remuzzi
BACKGROUND AND OBJECTIVES: The effect of mammalian target of rapamycin (mTOR) inhibitors has never been tested in patients with autosomal dominant polycystic kidney disease (ADPKD) and severe renal insufficiency. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this academic, prospective, randomized, open label, blinded end point, parallel group trial (ClinicalTrials.gov no. NCT01223755), 41 adults with ADPKD, CKD stage 3b or 4, and proteinuria ≤0.5 g/24 h were randomized between September of 2010 and March of 2012 to sirolimus (3 mg/d; serum target levels of 5-10 ng/ml) added on to conventional therapy (n=21) or conventional treatment alone (n=20)...
May 6, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26742301/-brunner-s-gland-adenoma-a-rare-tumor-as-cause-of-pyloric-syndrome-in-an-aids-patient
#18
Natalia Vittar, Marcelo Corti, Rubén Solari, Luis de Carolis, Olga Figueiras, Jorge Velásquez, Esteban Maronna
Brunner's gland adenoma is a rare neoplasm that accounts for only the 0.008% of all benign duodenal tumors. Here we describe the case ofan HIV-seropositive man who developed a severe pyloric stenosis due to a Brunner's adenoma of the bulb and the first duodenal portion. Gastroduodenoscopy showed a large polypoid tumor that obstructed the pyloric region. The lesion was resected by surgery and a gastroduodenal anastomosis was made. The histopathologic examination of the surgical specimen showed a large proliferation of Brunner's glands into a large pedunculated polyp that confirmed the diagnosis of this hamartoma...
2014: Acta Gastroenterologica Latinoamericana
https://www.readbyqxmd.com/read/26670971/maintenance-therapy-with-tumor-treating-fields-plus-temozolomide-vs-temozolomide-alone-for-glioblastoma-a-randomized-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Roger Stupp, Sophie Taillibert, Andrew A Kanner, Santosh Kesari, David M Steinberg, Steven A Toms, Lynne P Taylor, Frank Lieberman, Antonio Silvani, Karen L Fink, Gene H Barnett, Jay-Jiguang Zhu, John W Henson, Herbert H Engelhard, Thomas C Chen, David D Tran, Jan Sroubek, Nam D Tran, Andreas F Hottinger, Joseph Landolfi, Rajiv Desai, Manuela Caroli, Yvonne Kew, Jerome Honnorat, Ahmed Idbaih, Eilon D Kirson, Uri Weinberg, Yoram Palti, Monika E Hegi, Zvi Ram
IMPORTANCE: Glioblastoma is the most devastating primary malignancy of the central nervous system in adults. Most patients die within 1 to 2 years of diagnosis. Tumor-treating fields (TTFields) are a locoregionally delivered antimitotic treatment that interferes with cell division and organelle assembly. OBJECTIVE: To evaluate the efficacy and safety of TTFields used in combination with temozolomide maintenance treatment after chemoradiation therapy for patients with glioblastoma...
December 15, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26657164/peripheral-blood-natural-killer-cells-and-mild-thyroid-abnormalities-in-women-with-reproductive-failure
#20
P Triggianese, C Perricone, P Conigliaro, M S Chimenti, R Perricone, C De Carolis
Abnormalities in peripheral blood natural killer (NK) cells have been reported in women with primary infertility and recurrent spontaneous abortion (RSA) and several studies have been presented to define cutoff values for abnormal peripheral blood NK cell levels in this context. Elevated levels of NK cells were observed in infertile/RSA women in the presence of thyroid autoimmunity (TAI), while no studies have been carried out, to date, on NK cells in infertile/RSA women with non-autoimmune thyroid diseases...
March 2016: International Journal of Immunopathology and Pharmacology
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