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Leila Youssefian, Hassan Vahidnezhad, Amir Hossein Saeidian, Soheila Sotoudeh, Sirous Zeinali, Jouni Uitto
No abstract text is available yet for this article.
February 2017: American Journal of Gastroenterology
Pascal Wabnitz, Klaus-Thomas Kronmüller, Erwin Wieskus-Friedemann, Sabine Kliem, Johannes Hoppmann, Monika Burek, Michael Löhr, Ulrich Kemper, André Nienaber
"Nicht von schlechten Eltern - NischE": A Family Orientated Collaborative Care Approach to Support Children in Families with Mentally Ill Parents The present work describes the setting- and multi-professional offer "NischE" in Gütersloh, a systemic approach for the care of children and their mentally ill parents. Children of mentally ill parents are a special risk group for developing their own mental illness. The aim of the collaborative care model between child and adolescent psychiatry, youth services and adult psychiatry is to enable affected families in terms of family-focused practice a low threshold access to different services...
November 2016: Praxis der Kinderpsychologie und Kinderpsychiatrie
A Nienaber, E Wieskus-Friedemann, S Kliem, J Hoppmann, U Kemper, M Löhr, K-T Kronmüller, P Wabnitz
Objective: Evaluation of a project offering low-threshold anonymous counseling services jointly by mental health services and child and youth services to support children in families with mentally ill parents Methods: Evaluating performance data and completed questionnaires returned by parents included in the project. Results: Between 2011-2014, 150 families received up to 10 sessions of family-oriented counseling. The survey results indicate a high level of satisfaction with the services of the cooperation project...
February 2017: Das Gesundheitswesen
Mazvita Maziveyi, Suresh K Alahari
Tumor suppressor genes regulate cell growth and prevent spontaneous proliferation that could lead to aberrant tissue function. Deletions and mutations of these genes typically lead to progression through the cell-cycle checkpoints, as well as increased cell migration. Studies of these proteins are important as they may provide potential treatments for breast cancers. In this review, we discuss a comprehensive overview on Nischarin, a novel protein discovered by our laboratory. Nischarin, or imidazoline receptor antisera-selected protein, is a protein involved in a vast number of cellular processes, including neuronal protection and hypotension...
October 15, 2015: Cancer Research
Benjamin Keller, Jesús A García-Sevilla
Various imidazoline receptor (IR) proteins have been proposed to mediate the effects of selective I1- and I2-IR drugs. However, the association of these IR-binding proteins with classic I1- and I2-radioligand binding sites remains somewhat controversial. In this study, three IR antibodies (anti-NISCH and anti-nischarin for I1-IRs; and anti-IRBP for I1/I2-IRs) were used to immunodetect, characterize and compare IR protein patterns in brain (mouse and human; total homogenate, subcellular fractionation, grey and white matter) and some cell systems (neurones, astrocytes, human platelets)...
September 2015: Journal of Psychopharmacology
Jing Li, Xiaoying He, Ruofan Dong, Yuan Wang, Jinjin Yu, Haifeng Qiu
NISCH encodes the imidazoline receptor Nischarin and is a known tumor suppressor in many human malignancies; however, its roles in ovarian cancer are still largely unknown. Here, we aim to investigate the biologic functions of NISCH in ovarian cancer. We found that NISCH was significantly downregulated, which correlated considerably with advanced tumor stage, poor differentiation, lymph node metastasis, and the serous/mucinous subtypes in a panel of ovarian cancer tissues. Moreover, NISCH gene silencing was mainly the product of promoter hypermethylation, which could be reversed by treatment with 5-aza-dC...
May 2015: Molecular Cancer Therapeutics
Ting-Ting Yang, Ho-Shan Niu, Li-Jen Chen, Po-Ming Ku, Kao-Chang Lin, Juei-Tang Cheng
The aim of the present study was to identify the effect of canavanine on the imidazoline receptor because canavanine is a guanidinium derivative that has a similar structure to imidazoline receptor ligands. Transfected Chinese hamster ovary-K1 cells expressing imidazoline receptors (nischarin (NISCH)-CHO-K1 cells) were used to elucidate the direct effects of canavanine on imidazoline receptors. In addition, the imidazoline I3 receptor has been implicated in stimulation of insulin secretion from pancreatic β-cells...
March 2015: Clinical and Experimental Pharmacology & Physiology
Gunther Nisch, Hartmut Collmann
Friedrich Weickmann was one of the most distinguished neurosurgeons of the former German Democratic Republic and an eminent representative of the neurosurgical school established by Fedor Krause. For 25 years he was head of the neurosurgical department in Berlin-Buch, which he developed into an excellent nonuniversity center. Weickmann was the first German to publish a comprehensive text on pediatric neurosurgery. He deserves particular credit for defending the autonomy of the neurosurgical specialty and for promoting neuroradiology as a subspecialty of radiology...
January 2015: Journal of Neurological Surgery. Part A, Central European Neurosurgery
M Weinmann, W Nisch, A Stett, G Urban, V Bucher
No abstract text is available yet for this article.
September 7, 2013: Biomedizinische Technik. Biomedical Engineering
P Gnauck, C Burkhardt, H Wolburg, W Nisch
Extended abstract of a paper presented at Microscopy and Microanalysis 2005 in Honolulu, Hawaii, USA, July 31--August 4, 2005.
August 2005: Microscopy and Microanalysis
Kimberly Laskie Ostrow, Christina Michailidi, Rafael Guerrero-Preston, Mohammad O Hoque, Alissa Greenberg, William Rom, David Sidransky
We have previously identified a putative tumor suppressor gene, NISCH, whose promoter is methylated in lung tumor tissue as well as in plasma obtained from lung cancer patients. NISCH was observed to be more frequently methylated in smoker lung cancer patients than in non-smoker lung cancer patients. Here, we investigated the effect of tobacco smoke exposure on methylation of the NISCH gene. We tested methylation of NISCH after oral keratinocytes were exposed to mainstream and side stream cigarette smoke extract in culture...
April 2013: Epigenetics: Official Journal of the DNA Methylation Society
Pleun Hombrink, Chopie Hassan, Michel G D Kester, Arnoud H de Ru, Cornelis A M van Bergen, Harm Nijveen, Jan W Drijfhout, J H Frederik Falkenburg, Mirjam H M Heemskerk, Peter A van Veelen
T cell recognition of minor histocompatibility Ags (MiHA) plays an important role in the graft-versus-tumor effect of allogeneic stem cell transplantation. Selective infusion of T cells reactive for hematopoiesis-restricted MiHA presented in the context of HLA class I or II molecules may help to separate the graft-versus-tumor effects from graft-versus-host disease effects after allogeneic stem cell transplantation. Over the years, increasing numbers of MiHA have been identified by forward immunology approaches, and the relevance of these MiHA has been illustrated by correlation with clinical outcome...
April 15, 2013: Journal of Immunology: Official Journal of the American Association of Immunologists
L-Y Wang, P-M Ku, S-H Chen, L-J Chen, Y-M Yu, J-T Cheng
Specific antibodies are essential in the study of receptor protein. Gene matching shows that Nischarin (NISCH) is a mouse homologue of human imidazoline receptor antisera-selective (IRAS) protein, a viable candidate for imidazoline I-1 receptor. However, selectivity of this antibody against imidazoline I-2 or imidazoline I-3 receptors remained obscure. At first, an intracerebroventricular (ICV) injection of anti-NISCH antibody blocked the blood pressure lowering action of rilmenidine (I-1 receptor agonist) in spontaneous hypertensive rat (SHR)...
July 2013: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Lianjin Jin, Oliver Wessely, Eric G Marcusson, Cristina Ivan, George A Calin, Suresh K Alahari
miRNAs (miR) are a critical class of small (21-25 nucleotides) noncoding endogenous RNAs implicated in gene expression regulation. We identified miR-23b and miR-27b as miRNAs that are highly upregulated in human breast cancer. We found that engineered knockdown of miR-23b and miR-27b substantially repressed breast cancer growth. Nischarin (NISCH) expression was augmented by knockdown of miR-23b as well as miR-27b. Notably, these miRNAs and Nischarin were inversely expressed in human breast cancers, underscoring their biologic relevance...
May 1, 2013: Cancer Research
Kikuko Hotta, Aya Kitamoto, Takuya Kitamoto, Seiho Mizusawa, Hajime Teranishi, Rina So, Tomoaki Matsuo, Yoshio Nakata, Hideyuki Hyogo, Hidenori Ochi, Takahiro Nakamura, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Naoto Itoh, Ikuo Mineo, Jun Wada, Masato Yoneda, Atsushi Nakajima, Tohru Funahashi, Shigeru Miyazaki, Katsuto Tokunaga, Hiroaki Masuzaki, Takato Ueno, Kazuaki Chayama, Kazuyuki Hamaguchi, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Toshiie Sakata, Kiyoji Tanaka, Yuji Matsuzawa, Kazuwa Nakao, Akihiro Sekine
AIM: Visceral fat accumulation plays an integral role in morbidity and mortality rates by increasing the risk of developing metabolic disorders such as type 2 diabetes, dyslipidemia, and hypertension. New genetic loci associated with fat distribution, measured by waist-hip ratios and computed tomography (CT), have recently been identified by genome-wide association studies in European-descent populations. This study used CT to investigate whether single nucleotide polymorphisms (SNPs) that confer susceptibility to fat distribution are associated with visceral fat area (VFA) and subcutaneous fat area (SFA) in the Japanese population...
2013: Journal of Atherosclerosis and Thrombosis
Annamaria la Torre, Lucia Anna Muscarella, Paola Parrella, Teresa Balsamo, Michele Bisceglia, Vanna Maria Valori, Antonella la Torre, Raffaela Barbano, Eleonora Perrella, Maria Luana Poeta, Gennaro Melchionda, Giuseppe Merla, Evaristo Maiello, Riccardo Pellicano, Vito Michele Fazio
Disturbances in the epigenetic landscape by aberrant methylation of CpG islands can lead to inactivation of cancer-related genes in solid tumors. We analyzed the promoter methylation status of 6 genes previously reported as cancer-specific methylated (MCAM, SSBP2, NISCH, B4GALT1, KIF1A and RASSF1A) in 38 neural crest-derived tumors by quantitative methylation-specific real-time PCR (QMSP). The results demonstrated that the determination of the methylation status of RASSF1A is able to distinguish between normal and tumor samples in cutaneous melanomas, lung carcinoids and small bowel carcinoids...
October 2012: International Journal of Biological Markers
Mariana Brait, Myriam Loyo, Eli Rosenbaum, Kimberly L Ostrow, Alina Markova, Silvana Papagerakis, Marianna Zahurak, Steven M Goodman, Martha Zeiger, David Sidransky, Christopher B Umbricht, Mohammad O Hoque
Our aim was to comprehensively analyze promoter hypermethylation of a panel of novel and known methylation markers for thyroid neoplasms and to establish their relationship with BRAF mutation and clinicopathologic parameters of thyroid cancer. A cohort of thyroid tumors, consisting of 44 cancers and 44 benign thyroid lesions, as well as 15 samples of adjacent normal thyroid tissue, was evaluated for BRAF mutation and promoter hypermethylation. Genes for quantitative methylation specific PCR (QMSP) were selected by a candidate gene approach...
July 2012: Epigenetics: Official Journal of the DNA Methylation Society
Jeanne M McCaffery, George D Papandonatos, Inga Peter, Gordon S Huggins, Hollie A Raynor, Linda M Delahanty, Lawrence J Cheskin, Ashok Balasubramanyam, Lynne E Wagenknecht, Rena R Wing
BACKGROUND: Genome-wide association studies (GWAS) have identified consistent associations with obesity. However, the mechanisms remain unclear. OBJECTIVE: The objective was to determine the association between obesity susceptibility loci and dietary intake. DESIGN: The association of GWAS-identified obesity risk alleles (FTO, MC4R, SH2B1, BDNF, INSIG2, TNNI3K, NISCH-STAB1, MTIF3, MAP2K5, QPCTL/GIPR, and PPARG) with dietary intake, measured through food-frequency questionnaires, was investigated in 2075 participants from the Look AHEAD (Action for Health in Diabetes) clinical trial...
June 2012: American Journal of Clinical Nutrition
Natalia Briones, Valentin Dinu
BACKGROUND: The discovery of genetic associations is an important factor in the understanding of human illness to derive disease pathways. Identifying multiple interacting genetic mutations associated with disease remains challenging in studying the etiology of complex diseases. And although recently new single nucleotide polymorphisms (SNPs) at genes implicated in immune response, cholesterol/lipid metabolism, and cell membrane processes have been confirmed by genome-wide association studies (GWAS) to be associated with late-onset Alzheimer's disease (LOAD), a percentage of AD heritability continues to be unexplained...
2012: BMC Medical Genetics
Brigitte Grosse, Doris Cassio, Nadya Yousef, Céline Bernardo, Emmanuel Jacquemin, Emmanuel Gonzales
UNLABELLED: Neonatal ichthyosis and sclerosing cholangitis (NISCH) syndrome is a liver disease caused by mutations of CLDN1 encoding Claudin-1, a tight-junction (TJ) protein. In this syndrome, it is speculated that cholestasis is caused by Claudin-1 absence, leading to increased paracellular permeability and liver injuries secondary to paracellular bile regurgitation. We studied the role of claudin-1 in hepatic paracellular permeability. A NISCH liver and polarized rat cell lines forming TJs, the hepatocellular Can 10 and the cholangiocellular normal rat choloangiocyte (NRC), were used...
April 2012: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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