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Jie Zhang, Ting Liu, Qiang-Qiang Ma, Shujun Li, Xuenian Chen
C-S bond activation of thiophenols and mercaptans is of great importance but has rarely been reported. In this paper we report the C-S bond cleavage of the thiolato ligand of [2,6-(tBu2PO)2C6H3]NiSCH2Ph (1) mediated by BH3·THF. The treatment of 1 with an excess amount of BH3·THF in THF at room temperature afforded the borohydride complex [2,6-(tBu2PO)2C6H3]Ni(η2-BH4) (2) as the only product. The reaction of 1 with 2 equiv. of BH3·THF in THF at room temperature for 48 h produced the hydride complex [2,6-(tBu2PO)2C6H3]NiH (3) and the mercapto complex [2,6-(tBu2PO)2C6H3]NiSH (5)...
May 1, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
S Szepetowski, C Lacoste, S Mallet, B Roquelaure, C Badens, A Fabre
NISCH syndrome is a rare autosomal recessive disease. It is characterized by scalp hypotrichosis, scarring alopecia, ichthyosis, and neonatal sclerosing cholangitis. It is caused by mutations in the CLDN1 gene encoding the claudin-1 protein, which is located at tight junctions. Fifteen cases have been reported to date and three different mutations have been identified. We report on the case of a 2-year-old boy from a consanguineous Moroccan family, presenting with NISCH syndrome and carrying the so-called Moroccan homozygous mutation (c...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Mahmood F Bhutta, Jane Lambie, Lindsey Hobson, Anuj Goel, Lena Hafrén, Elisabet Einarsdottir, Petri S Mattila, Martin Farrall, Steve Brown, Martin J Burton
Chronic otitis media with effusion (COME) is the most common cause of hearing loss in children, and known to have high heritability. Mutant mouse models have identified Fbxo11, Evi1, Tgif1, and Nisch as potential risk loci. We recruited children aged 10 and under undergoing surgical treatment for COME from 35 hospitals in the UK, and their nuclear family. We performed association testing with the loci FBXO11, EVI1, TGIF1 and NISCH and sought to replicate significant results in a case-control cohort from Finland...
October 2, 2017: Scientific Reports
Shengli Dong, Somesh Baranwal, Anapatricia Garcia, Silvia J Serrano-Gomez, Steven Eastlack, Tomoo Iwakuma, Donald Mercante, Franck Mauvais-Jarvis, Suresh K Alahari
Nischarin (Nisch) is a key protein functioning as a molecular scaffold and thereby hosting interactions with several protein partners. To explore the physiological importance of Nisch, here we generated Nisch loss-of-function mutant mice and analyzed their metabolic phenotype. Nisch-mutant embryos exhibited delayed development, characterized by small size and attenuated weight gain. We uncovered the reason for this phenotype by showing that Nisch binds to and inhibits the activity of AMP-activated protein kinase (AMPK), which regulates energy homeostasis by suppressing anabolic and activating catabolic processes...
October 13, 2017: Journal of Biological Chemistry
Michael Crompton, Tom Purnell, Hayley E Tyrer, Andrew Parker, Greg Ball, Rachel E Hardisty-Hughes, Richard Gale, Debbie Williams, Charlotte H Dean, Michelle M Simon, Ann-Marie Mallon, Sara Wells, Mahmood F Bhutta, Martin J Burton, Hilda Tateossian, Steve D M Brown
Otitis media (OM), inflammation of the middle ear (ME), is a common cause of conductive hearing impairment. Despite the importance of the disease, the aetiology of chronic and recurrent forms of middle ear inflammatory disease remains poorly understood. Studies of the human population suggest that there is a significant genetic component predisposing to the development of chronic OM, although the underlying genes are largely unknown. Using N-ethyl-N-nitrosourea mutagenesis we identified a recessive mouse mutant, edison, that spontaneously develops a conductive hearing loss due to chronic OM...
August 2017: PLoS Genetics
Mang Hung Lin, Chia-Chen Hsu, Jenshinn Lin, Juei Tang Cheng, Ming Chang Wu
Morin is a flavonoid contained in guava that is known to reduce hyperglycemia in diabetes. Insulin secretion has been demonstrated to increase following the administration of morin. The present study is designed to investigate the potential mechanism(s) of morin-induced insulin secretion in the MIN6 cell line. First, we identified that morin induced a dose-dependent increase in insulin secretion and intracellular calcium content in MIN6 cells. Morin potentiated glucose-stimulated insulin secretion (GSIS). Additionally, we used siRNA for the ablation of imidazoline receptor protein (NISCH) expression in MIN6 cells...
July 12, 2017: Clinical and Experimental Pharmacology & Physiology
Mang Hung Lin, Chia-Chen Hsu, Jenshinn Lin, Juei-Tang Cheng, Ming Chang Wu
Morin is a flavonoid contained in guava that is known to reduce hyperglycemia in diabetics. Morin has been demonstrated to increase plasma insulin. However, the mechanism(s) remains unknown. The present study is designed to investigate the effect of morin on the imidazoline receptor (I-R) that regulates insulin secretion. We used Chinese hamster ovary (CHO) cells transfected with an I-R expression construct (NISCH-CHO-K1 cells) to identify the direct effect of morin on the I-R. Moreover, the imidazoline I3 receptor (I-3R) is known to be present in pancreatic β cells and involved in insulin secretion...
October 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
Caitlin Uren, Brenna M Henn, Andre Franke, Michael Wittig, Paul D van Helden, Eileen G Hoal, Marlo Möller
Utilizing data from published tuberculosis (TB) genome-wide association studies (GWAS), we use a bioinformatics pipeline to detect all polymorphisms in linkage disequilibrium (LD) with variants previously implicated in TB disease susceptibility. The probability that these variants had a predicted regulatory function was estimated using RegulomeDB and Ensembl's Variant Effect Predictor. Subsequent genotyping of these 133 predicted regulatory polymorphisms was performed in 400 admixed South African TB cases and 366 healthy controls in a population-based case-control association study to fine-map the causal variant...
2017: PloS One
Chandramouli Rathnam, Sanghoon Lee, Xia Jiang
OBJECTIVE: This study aims at developing and introducing a new algorithm, called direct causal learner (DCL), for learning the direct causal influences of a single target. We applied it to both simulated and real clinical and genome wide association study (GWAS) datasets and compared its performance to classic causal learning algorithms. METHOD: The DCL algorithm learns the causes of a single target from passive data using Bayesian-scoring, instead of using independence checks, and a novel deletion algorithm...
January 2017: Artificial Intelligence in Medicine
Leila Youssefian, Hassan Vahidnezhad, Amir Hossein Saeidian, Soheila Sotoudeh, Sirous Zeinali, Jouni Uitto
No abstract text is available yet for this article.
February 2017: American Journal of Gastroenterology
Pascal Wabnitz, Klaus-Thomas Kronmüller, Erwin Wieskus-Friedemann, Sabine Kliem, Johannes Hoppmann, Monika Burek, Michael Löhr, Ulrich Kemper, André Nienaber
"Nicht von schlechten Eltern - NischE": A Family Orientated Collaborative Care Approach to Support Children in Families with Mentally Ill Parents The present work describes the setting- and multi-professional offer "NischE" in Gütersloh, a systemic approach for the care of children and their mentally ill parents. Children of mentally ill parents are a special risk group for developing their own mental illness. The aim of the collaborative care model between child and adolescent psychiatry, youth services and adult psychiatry is to enable affected families in terms of family-focused practice a low threshold access to different services...
November 2016: Praxis der Kinderpsychologie und Kinderpsychiatrie
A Nienaber, E Wieskus-Friedemann, S Kliem, J Hoppmann, U Kemper, M Löhr, K-T Kronmüller, P Wabnitz
Objective: Evaluation of a project offering low-threshold anonymous counseling services jointly by mental health services and child and youth services to support children in families with mentally ill parents Methods: Evaluating performance data and completed questionnaires returned by parents included in the project. Results: Between 2011-2014, 150 families received up to 10 sessions of family-oriented counseling. The survey results indicate a high level of satisfaction with the services of the cooperation project...
February 2017: Das Gesundheitswesen
Mazvita Maziveyi, Suresh K Alahari
Tumor suppressor genes regulate cell growth and prevent spontaneous proliferation that could lead to aberrant tissue function. Deletions and mutations of these genes typically lead to progression through the cell-cycle checkpoints, as well as increased cell migration. Studies of these proteins are important as they may provide potential treatments for breast cancers. In this review, we discuss a comprehensive overview on Nischarin, a novel protein discovered by our laboratory. Nischarin, or imidazoline receptor antisera-selected protein, is a protein involved in a vast number of cellular processes, including neuronal protection and hypotension...
October 15, 2015: Cancer Research
Benjamin Keller, Jesús A García-Sevilla
Various imidazoline receptor (IR) proteins have been proposed to mediate the effects of selective I1- and I2-IR drugs. However, the association of these IR-binding proteins with classic I1- and I2-radioligand binding sites remains somewhat controversial. In this study, three IR antibodies (anti-NISCH and anti-nischarin for I1-IRs; and anti-IRBP for I1/I2-IRs) were used to immunodetect, characterize and compare IR protein patterns in brain (mouse and human; total homogenate, subcellular fractionation, grey and white matter) and some cell systems (neurones, astrocytes, human platelets)...
September 2015: Journal of Psychopharmacology
Jing Li, Xiaoying He, Ruofan Dong, Yuan Wang, Jinjin Yu, Haifeng Qiu
NISCH encodes the imidazoline receptor Nischarin and is a known tumor suppressor in many human malignancies; however, its roles in ovarian cancer are still largely unknown. Here, we aim to investigate the biologic functions of NISCH in ovarian cancer. We found that NISCH was significantly downregulated, which correlated considerably with advanced tumor stage, poor differentiation, lymph node metastasis, and the serous/mucinous subtypes in a panel of ovarian cancer tissues. Moreover, NISCH gene silencing was mainly the product of promoter hypermethylation, which could be reversed by treatment with 5-aza-dC...
May 2015: Molecular Cancer Therapeutics
Ting-Ting Yang, Ho-Shan Niu, Li-Jen Chen, Po-Ming Ku, Kao-Chang Lin, Juei-Tang Cheng
The aim of the present study was to identify the effect of canavanine on the imidazoline receptor because canavanine is a guanidinium derivative that has a similar structure to imidazoline receptor ligands. Transfected Chinese hamster ovary-K1 cells expressing imidazoline receptors (nischarin (NISCH)-CHO-K1 cells) were used to elucidate the direct effects of canavanine on imidazoline receptors. In addition, the imidazoline I3 receptor has been implicated in stimulation of insulin secretion from pancreatic β-cells...
March 2015: Clinical and Experimental Pharmacology & Physiology
Gunther Nisch, Hartmut Collmann
Friedrich Weickmann was one of the most distinguished neurosurgeons of the former German Democratic Republic and an eminent representative of the neurosurgical school established by Fedor Krause. For 25 years he was head of the neurosurgical department in Berlin-Buch, which he developed into an excellent nonuniversity center. Weickmann was the first German to publish a comprehensive text on pediatric neurosurgery. He deserves particular credit for defending the autonomy of the neurosurgical specialty and for promoting neuroradiology as a subspecialty of radiology...
January 2015: Journal of Neurological Surgery. Part A, Central European Neurosurgery
M Weinmann, W Nisch, A Stett, G Urban, V Bucher
No abstract text is available yet for this article.
September 7, 2013: Biomedizinische Technik. Biomedical Engineering
P Gnauck, C Burkhardt, H Wolburg, W Nisch
Extended abstract of a paper presented at Microscopy and Microanalysis 2005 in Honolulu, Hawaii, USA, July 31--August 4, 2005.
August 2005: Microscopy and Microanalysis
Kimberly Laskie Ostrow, Christina Michailidi, Rafael Guerrero-Preston, Mohammad O Hoque, Alissa Greenberg, William Rom, David Sidransky
We have previously identified a putative tumor suppressor gene, NISCH, whose promoter is methylated in lung tumor tissue as well as in plasma obtained from lung cancer patients. NISCH was observed to be more frequently methylated in smoker lung cancer patients than in non-smoker lung cancer patients. Here, we investigated the effect of tobacco smoke exposure on methylation of the NISCH gene. We tested methylation of NISCH after oral keratinocytes were exposed to mainstream and side stream cigarette smoke extract in culture...
April 2013: Epigenetics: Official Journal of the DNA Methylation Society
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