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https://www.readbyqxmd.com/read/29761764/case-report-filaria-or-megasperm-a-cause-of-an-ultrasonographic-filarial-dance-sign
#1
J Brad Wiggers, Hyun-Jung Jang, Jay S Keystone
Bancroftian filariasis can cause genital abnormalities related to chronic inflammation and obstruction of the afferent lymphatic vessels, and may demonstrate a "filarial dance sign" on scrotal ultrasound with mobile echogenic particles observed. We present a patient with a positive "filarial dance sign," travel within Latin America and negative filarial serology.
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29716541/onchocerca-infected-cattle-produce-strong-antibody-responses-to-excretory-secretory-proteins-released-from-adult-male-onchocerca-ochengi-worms
#2
Djafsia Boursou, Dieudonné Ndjonka, Albert Eisenbarth, Kingsley Manchang, Archille Paguem, Nancy Ngwafu Ngwasiri, Jacqueline Dikti Vildina, Babette Abanda, Ralf Krumkamp, Silke van Hoorn, Alfons Renz, Mbunkah Daniel Achukwi, Eva Liebau, Norbert W Brattig
BACKGROUND: The front line molecules from filarial worms and other nematodes or helminthes are their Excretory-Secretory (ES) products. Their interaction with the host cells, proteins and immune system accounts for the skin and eye pathology or hyposensitivity observed in human onchocerciasis. ES products and adult worms' crude extracts from Onchocerca ochengi, a filarial nematode that infects the African zebu cattle, were utilized in the present study as a model for studying Onchocerca volvulus that causes river blindness in man...
May 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29618330/filaria-specific-antibody-response-profiling-in-plasma-from-anti-retroviral-na%C3%A3-ve-loa-loa-microfilaraemic-hiv-1-infected-people
#3
Ghislain Donald Njambe Priso, Abel Lissom, Loveline N Ngu, Nadesh N Nji, Jules Colince Tchadji, Thibau Flaurant Tchouangueu, Georgia E Ambada, Carole Stéphanie Sake Ngane, Brigitte Laure Dafeu, Larissa Djukouo, Inès Nyebe, Suzanne Magagoum, Apeh Alfred Ngoh, Ouambo Fotso Herve, Rosario Garcia, Anna Gutiérrez, Arinze S Okoli, Charles O Esimone, Flobert Njiokou, Chae Gyu Park, Alain Bopda Waffo, Godwin W Nchinda
BACKGROUND: In West and Central Africa areas of endemic Loa loa infections overlap with regions of high prevalence of human immunodeficiency virus type 1 (HIV-1) infections. Because individuals in this region are exposed to filarial parasites from birth, most HIV-1 infected individuals invariably also have a history of filarial parasite infection. Since HIV-1 infection both depletes immune system and maintains it in perpetual inflammation, this can hamper Loa loa filarial parasite mediated immune modulation, leading to enhanced loaisis...
April 4, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29611501/comparison-of-pcr-methods-for-onchocerca-volvulus-detection-in-skin-snip-biopsies-from-the-tshopo-province-democratic-republic-of-the-congo
#4
Jessica Prince-Guerra, Vitaliano Cama, Nana Wilson, Elizabeth A Thiele, Josias Likwela, Nestor N Gyamba, Jacques Muzinga Wa Muzinga, Nicholas Ayebazibwe, Yassa D Ndjakani, Naomi A Pitchouna, Dieudonne M Ngoyi, Antoinette K Tshefu, Guilherme Ogawa, Paul T Cantey
Defining the optimal diagnostic tools for evaluating onchocerciasis elimination efforts in areas co-endemic for other filarial nematodes is imperative. This study compared three published PCR methods: the Onchocerca volvulus -specific qPCR-O150, the pan-filarial qPCR melt curve analysis (MCA), and the O150-PCR ELISA currently used for vector surveillance in skin snip biopsies (skin snips) collected from the Democratic Republic of the Congo. The pan-filarial qPCR-MCA was compared with species-specific qPCRs for Loa loa and Mansonella perstans ...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29606157/co-infection-with-filarial-nematodes-in-sapajus-macrocephalus-and-cebus-albifrons-primates-cebidae-from-the-peruvian-amazon
#5
D F Conga, P Mayor, A P Furtado, E G Giese, J N Santos
Dipetalonema caudispina (Molin, 1858) and D. gracile (Rudolphi, 1809) (Filarioidea: Onchocercidae) are two of six known species of filarial nematodes that parasitize Neotropical non-human primates. Adult filariae were collected from the thoracic and abdominal cavities of 38 of 44 specimens of Sapajus macrocephalus (Spix, 1823) and nine of ten specimens of Cebus albifrons (Humboldt, 1812) (Primates: Cebidae), distributed in the Yavarí-Mirín river basin and used locally for human consumption. Co-occurrence of D...
April 2, 2018: Journal of Helminthology
https://www.readbyqxmd.com/read/29575054/living-together-malaria-and-filaria
#6
Vikarn Vishwajeet, Man Updesh Singh Sachdeva
No abstract text is available yet for this article.
March 25, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29490766/association-between-urticaria-and-nematode-infections
#7
Paola L Minciullo, Antonio Cascio, Sebastiano Gangemi
BACKGROUND: The association between parasites and urticaria was first suggested in the last century. A wide range, 0-75.4%, of the prevalence of parasitic infection has been reported with chronic urticaria (CU). Moreover, urticaria may be detected in patients with parasitosis. Nematodes are a type of helminth that infect hundreds of millions of people throughout the world. OBJECTIVE: The aim of this work was to collect and review the published studies and cases of urticaria associated with nematode infections...
March 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29390149/cord-blood-antiparasite-interleukin-10-as-a-risk-marker-for-compromised-vaccine-immunogenicity-in-early-childhood
#8
Indu Malhotra, A Desiree LaBeaud, Nathan Morris, Maxim McKibben, Peter Mungai, Eric Muchiri, Christopher L King, Charles H King
Background: Antenatal exposure to parasites can affect infants' subsequent responses to vaccination. The present study investigated how maternal prenatal infections and newborns' antiparasite cytokine profiles relate to immunoglobulin G (IgG) responses to standard vaccination during infancy. Methods: A total of 450 Kenyan women were tested for parasitic infections during pregnancy. Their newborns' responses to Plasmodium falciparum, schistosome, and filaria antigens were assessed in cord blood lymphocytes...
April 11, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29386706/filaria-surveys-in-the-armed-forces-need-for-a-revisit
#9
Arvind Singh Kushwaha, K C Verma, M P Cariappa
Background: Routine annual filarial surveys are conducted amongst various categories of military personnel and their families as per policies in vogue in the Armed Forces. The neglect and inattention faced by this disease needs to be addressed in terms of policy, provisioning and processes while dealing with filariasis in the Armed Forces. Methods: Routine annual filarial survey was conducted in a garrison during the months of Nov and Dec in 2013 and 2014. Blood slides from 6305 and 10,162 persons were collected in 2013 and 2014 respectively...
October 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29289559/geographical-distribution-and-species-identification-of-human-filariasis-and-onchocerciasis-in-bioko-island-equatorial-guinea
#10
Thuy-Huong Ta, Laura Moya, Justino Nguema, Pilar Aparicio, María Miguel-Oteo, Gema Cenzual, Isabel Canorea, Marta Lanza, Agustín Benito, James Lee Crainey, José Miguel Rubio
Human filariae are vector-borne parasites and the causative agents of various diseases, including human onchocerciasis and lymphatic filariasis. Onchocerciasis causes a spectrum of cutaneous and ophthalmologic manifestations (including blindness) and has long been a major public health problem in Bioko Island (Equatorial Guinea). Bioko Island has been included in the WHO's Onchocerciasis Control Program since 1987. In Bioko Island, the specificity and sensitivity of clinical Onchocerca volvulus diagnosis is key...
April 2018: Acta Tropica
https://www.readbyqxmd.com/read/29261659/assessment-of-maldi-tof-mass-spectrometry-for-filariae-detection-in-aedes-aegypti-mosquitoes
#11
Djamel Tahir, Lionel Almeras, Marie Varloud, Didier Raoult, Bernard Davoust, Philippe Parola
Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) is an emerging tool for routine identification of bacteria, archaea and fungi. It has also been recently applied as an accurate approach for arthropod identification. Preliminary studies have shown that the MALDI-TOF MS was able to differentiate whether ticks and mosquitoes were infected or not with some bacteria and Plasmodium parasites, respectively. The aim of the present study was to test the efficiency of MALDI-TOF MS tool in distinguishing protein profiles between uninfected mosquitoes from specimens infected by filarioid helminths...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29141050/differential-immunomodulation-in-human-monocytes-versus-macrophages-by-filarial-cystatin
#12
Gopinath Venugopal, Marion Mueller, Susanne Hartmann, Svenja Steinfelder
Parasitic nematodes have evolved powerful immunomodulatory molecules to enable their survival in immunocompetent hosts by subverting immune responses and minimizing pathological processes. One filarial molecule known to counteract host immune responses by inducing IL-10 and regulatory macrophages in mice is filarial cystatin. During a patent filarial infection monocytes encounter microfilariae in the blood, an event that occurs in asymptomatically infected filariasis patients that are immunologically hyporeactive...
2017: PloS One
https://www.readbyqxmd.com/read/29126431/successful-long-term-maintenance-of-mansonella-perstans-in-an-in-vitro-culture-system
#13
Abdel Jelil Njouendou, Manuel Ritter, Winston Patrick Chounna Ndongmo, Chi Anizette Kien, Gandjui Tchamatchoua Victor Narcisse, Fanny Fri Fombad, Dizzle Bita Tayong, Kenneth Pfarr, Laura E Layland, Achim Hoerauf, Samuel Wanji
BACKGROUND: Approximately 114 million people are infected with Mansonella perstans in large proportions of Africa. In contrast to other filariae that infect humans, M. perstans-infected individuals show no distinct pathology or specific clinical picture, indicating a well-tuned adaptation to the host. In addition, since M. perstans adult worms reside in serous cavities which are difficult to access, research has been hindered and there is a paucity of knowledge about the biology of M...
November 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29114130/phylogenetic-study-based-on-28s-rrna-gene-sequencing-of-wuchereria-bancrofti-isolated-from-the-filaria-endemic-areas-of-bankura-district-west-bengal-india
#14
Soumendranath Chatterjee, Swapan Kumar Rudra, Syed Afrin Azmi, Raktima Bandyopadhyay
Lymphatic filariasis is one of the major public health concern in India, and Bankura district of West Bengal is one of the main filaria prone area of the country. Wuchereria bancrofti is the causative organism and Culex quinquefasciatus is the main vector of lymphatic filariasis in India. In the present study, infection and infectivity rate of filarial vector C. quinquefasciatus were determined. The molecular characterization, DNA fingerprinting and phylogenetic analysis of W. bancrofti was done. In the study area, overall vector infection and infectivity rates were 4...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28969836/therapeutic-trial-of-doxycyclin-plus-ivermectin-for-the-treatment-of-brugia-malayi-naturally-infected-cats
#15
Ladawan Khowawisetsut, Patsharaporn T Sarasombath, Suwich Thammapalo, Sumart Loymek, Therayot Korbarsa, Hathai Nochote, Achinya Phuakrod, Wej Choochote, Sirichit Wongkamchai
Lymphatic filariasis (LF) is one of the neglected tropical diseases which causes permanent and long term disability worldwide. LF is caused by filarial nematode parasites, i.e. Wuchereria bancrofti, Brugia malayi, and B. timori. All available antifilarial drugs currently being used have shown a limited adulticidal activity. Discoveries of endosymbiont rickettsia-like bacterium, Wolbachia in filarial nematodes provided a novel approach for antibiotic use in eradication of filarial diseases. The earlier studies revealed the macrofilaricidal efficacy of doxycycline against filarial nematodes...
October 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28859850/il-4-5-signalling-plays-an-important-role-during-litomosoides-sigmodontis-infection-influencing-both-immune-system-regulation-and-tissue-pathology-in-the-thoracic-cavity
#16
Manuel Ritter, Ruth S Tamadaho, Judith Feid, Wenzel Vogel, Katharina Wiszniewsky, Sven Perner, Achim Hoerauf, Laura E Layland
Approximately 100 million people suffer from filarial diseases including lymphatic filariasis (elephantiasis), onchocerciasis (river blindness) and loiasis. These diseases are amongst the most devastating of the neglected tropical diseases in terms of social and economic impact. Moreover, many infection-induced immune mechanisms in the host, their relationship to disease-related symptoms and the development of pathology within the site of infection remain unclear. To improve on current drug therapies or vaccines, further studies are necessary to decipher the mechanisms behind filaria-driven immune responses and pathology development, and thus the rodent model of Litomosoides sigmodontis can be used to unravel host-filaria interactions...
December 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28727765/defining-the-target-and-the-effect-of-imatinib-on-the-filarial-c-abl-homologue
#17
Elise M O'Connell, Olena Kamenyeva, Sara Lustigman, Aaron Bell, Thomas B Nutman
BACKGROUND: Previously we demonstrated the micro- and macrofilaricidal properties of imatinib in vitro. Here we use electron and multiphoton microscopy to define the target of imatinib in the adult and microfilarial stages of Brugia malayi and assess the effects of pharmacologically relevant levels of imatinib on the adult parasites. METHODS: After fixation of adult B. malayi males and females, sections were stained with polyclonal rabbit anti-c-Abl antibody (or isotype control) and imaged with multiphoton fluorescent microscopy...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28654231/enhanced-adhesion-of-mosquitoes-to-rough-surfaces
#18
Leila Pashazanusi, Baraka Lwoya, Shreyas Oak, Tushar Khosla, Julie N L Albert, Yu Tian, Geetha Bansal, Nirbhay Kumar, Noshir S Pesika
Insects and small animals capable of adhering reversibly to a variety of surfaces employ the unique design of the distal part of their legs. In the case of mosquitoes, their feet are composed of thousands of micro- and nanoscale protruding structures, which impart superhydrophobic properties. Previous research has shown that the superhydrophobic nature of the feet allows mosquitoes to land on water, which is necessary for their reproduction cycle. Here, we show that van der Waals interactions are the main adhesion mechanism employed by mosquitoes to adhere to various surfaces...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28617666/parasitic-diseases-of-camels-in-iran-1931-2017-a-literature-review
#19
Alireza Sazmand, Anja Joachim
Parasitic diseases of camels are major causes of impaired milk and meat production, decreases in performance or even death. Some camel parasites also represent a threat to human health. About 171,500 one-humped camels (Camelus dromedarius) and 100-300 two-humped camels (Camelus bactrianus) live in Iran. Knowledge of the biodiversity of their parasites is still limited. The present review covers all information about camel parasitic diseases in Iran published as dissertations and in both Iranian and international journals from 1931 to February 2017...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/28558828/eprinomectin-pour-on-eprinex%C3%A2-pour-on-merial-efficacy-against-gastrointestinal-and-pulmonary-nematodes-and-pharmacokinetics-in-sheep
#20
RANDOMIZED CONTROLLED TRIAL
Dietmar Hamel, Antonio Bosco, Laura Rinaldi, Giuseppe Cringoli, Karl-Heinz Kaulfuß, Michael Kellermann, James Fischer, Hailun Wang, Katrin Kley, Sandra Mayr, Renate Rauh, Martin Visser, Thea Wiefel, Becky Fankhauser, Steffen Rehbein
BACKGROUND: The anthelmintic efficacy of the 0.5% w/v topical formulation of eprinomectin (EPN), EPRINEX® Pour-on (Merial) when administered at 1 mg/kg body weight was evaluated in sheep in two dose confirmation laboratory studies and one multicenter field study. In addition, the pharmacokinetics of EPN when administered at that dosage to adult sheep was determined. RESULTS: In the two dose confirmation studies, which included 10 sheep each, sheep treated with topical EPN had significantly (p < 0...
May 30, 2017: BMC Veterinary Research
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