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https://www.readbyqxmd.com/read/27828973/immunization-with-brugia-malayi-myosin-as-heterologous-dna-prime-protein-boost-induces-protective-immunity-against-b-malayi-infection-in-mastomys-coucha
#1
Jyoti Gupta, Sweta Misra, Shailja Misra-Bhattacharya
The current control strategies employing chemotherapy with diethylcarbamazine, ivermectin and albendazole have reduced transmission in some filaria-endemic areas, there is growing interest for complementary approaches, such as vaccines especially in light of threat of parasite developing resistance to mainstay drugs. We earlier demonstrated recombinant heavy chain myosin of B. malayi (Bm-Myo) as a potent vaccine candidate whose efficacy was enhanced by heterologous DNA prime/protein boost (Myo-pcD+Bm-Myo) vaccination in BALB/c mice...
2016: PloS One
https://www.readbyqxmd.com/read/27790964/increased-igg-antibody-responses-to-excretory-secretory-antigens-in-neonates-born-from-mothers-infected-with-filarial-nematodes
#2
K G Achary, M S Bal, N N Mandal, A K Satapathy
The present investigation aimed to evaluate the extent to which maternal filarial infection influences IgG subclass immune responses in the cord blood of neonates. Prevalence of antigenaemia was detected using an Og4C3 assay. Filaria-specific IgG subclasses against excretory/secretory antigens were measured by ELISA. Transplacental transfer of circulating filarial antigen (CFA) was observed from 34.8% of CFA-positive mothers to their respective cord bloods. Filaria-specific IgG1, IgG2 and IgG4 responses were significantly higher among cord bloods of infected mothers compared to cord bloods of uninfected mothers...
October 28, 2016: Journal of Helminthology
https://www.readbyqxmd.com/read/27529747/the-effects-of-ivermectin-on-brugia-malayi-females-in-vitro-a-transcriptomic-approach
#3
Cristina Ballesteros, Lucienne Tritten, Maeghan O'Neill, Erica Burkman, Weam I Zaky, Jianguo Xia, Andrew Moorhead, Steven A Williams, Timothy G Geary
BACKGROUND: Lymphatic filariasis and onchocerciasis are disabling and disfiguring neglected tropical diseases of major importance in developing countries. Ivermectin is the drug of choice for mass drug administration programs for the control of onchocerciasis and lymphatic filariasis in areas where the diseases are co-endemic. Although ivermectin paralyzes somatic and pharyngeal muscles in many nematodes, these actions are poorly characterized in adult filariae. We hypothesize that paralysis of pharyngeal pumping by ivermectin in filariae could result in deprivation of essential nutrients, especially iron, inducing a wide range of responses evidenced by altered gene expression, changes in metabolic pathways, and altered developmental states in embryos...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27417080/finding-wolbachia-in-filarial-larvae-and-culicidae-mosquitoes-in-upper-egypt-governorate
#4
Ahmed K Dyab, Lamia A Galal, Abeer E Mahmoud, Yasser Mokhtar
Wolbachia is an obligatory intracellular endosymbiotic bacterium, present in over 20% of all insects altering insect reproductive capabilities and in a wide range of filarial worms which is essential for worm survival and reproduction. In Egypt, no available data were found about Wolbachia searching for it in either mosquitoes or filarial worms. Thus, we aimed to identify the possible concurrent presence of Wolbachia within different mosquitoes and filarial parasites, in Assiut Governorate, Egypt using multiplex PCR...
June 2016: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/27408801/gray-fox-urocyon-cinereoargenteus-parasite-diversity-in-central-mexico
#5
Norma Hernández-Camacho, Raúl Francisco Pineda-López, María de Jesús Guerrero-Carrillo, Germinal Jorge Cantó-Alarcón, Robert Wallace Jones, Marco Antonio Moreno-Pérez, Juan Joel Mosqueda-Gualito, Salvador Zamora-Ledesma, Brenda Camacho-Macías
Mexico has a long history of parasitological studies in communities of vertebrates. However, the mega diversity of the country makes fauna inventories an ongoing priority. Presently, there is little published on the parasite fauna of gray foxes (Urocyon cinereoargenteus Schereber, 1775) and this study provides new records of parasites for gray foxes in central Mexico. It is a continuation of a series of previous parasitological studies conducted with this carnivore in Mexico from 2003 to the present. A total of 24 foxes in the Parque Nacional El Cimatario (PANEC) were trapped, anaesthetized, and parasites recovered...
August 2016: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/27392244/phenylethylchromones-with-in-vitro-antitumor-promoting-activity-from-aquilaria-filaria
#6
Airi Suzuki, Katsunori Miyake, Yohei Saito, Faradiba Abdul Rasyid, Harukuni Tokuda, Misa Takeuchi, Nobutaka Suzuki, Eiichiro Ichiishi, Tetsuo Fujie, Masuo Goto, Yohei Sasaki, Kyoko Nakagawa-Goto
A new chromone, 2-(2-hydroxy-2-phenylethyl)chromone (1), was isolated together with ten known phenylethyl chromones from MeOH extracts of agarwood (Aquilaria filaria). The selected compounds were evaluated in an antiproliferative assay against five human tumor cell lines, including a multidrug-resistant cell line. They were also tested for antitumor promoting activity, as mediated by 12-O-tetradecanoylphorbol-13-acetate-induced activation of the Epstein-Barr virus early antigen in Raji cells. Among all compounds, 4',7-dimethyoxy-6-hydroxychromone (2) displayed broad spectrum antiproliferative activity against all tumor cell lines tested with IC50 values of 25-38 µM, while 8 was selectively inhibitory against multidrug-resistant cells...
July 8, 2016: Planta Medica
https://www.readbyqxmd.com/read/27357128/exposure-to-vector-borne-pathogens-in-candidate-blood-donor-and-free-roaming-dogs-of-northeast-italy
#7
Marta Vascellari, Silvia Ravagnan, Antonio Carminato, Stefania Cazzin, Erika Carli, Graziana Da Rold, Laura Lucchese, Alda Natale, Domenico Otranto, Gioia Capelli
BACKGROUND: Many vector-borne pathogens including viruses, bacteria, protozoa and nematodes occur in northeast Italy, representing a potential threat to animal and human populations. Little information is available on the circulation of the above vector-borne pathogens in dogs. This work aims to (i) assess exposure to and circulation of pathogens transmitted to dogs in northeast Italy by ticks, sandflies, and mosquitoes, and (ii) drive blood donor screening at the newly established canine blood bank of the Istituto Zooprofilattico Sperimentale delle Venezie...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27322330/mobile-diagnostics-based-on-motion-a-close-look-at-motility-patterns-in-the-schistosome-life-cycle
#8
Ewert Linder, Sami Varjo, Cecilia Thors
Imaging at high resolution and subsequent image analysis with modified mobile phones have the potential to solve problems related to microscopy-based diagnostics of parasitic infections in many endemic regions. Diagnostics using the computing power of "smartphones" is not restricted by limited expertise or limitations set by visual perception of a microscopist. Thus diagnostics currently almost exclusively dependent on recognition of morphological features of pathogenic organisms could be based on additional properties, such as motility characteristics recognizable by computer vision...
2016: Diagnostics
https://www.readbyqxmd.com/read/27273645/associations-between-helminth-infections-plasmodium-falciparum-parasite-carriage-and-antibody-responses-to-sexual-and-asexual-stage-malarial-antigens
#9
Ulysse Ateba-Ngoa, Sophie Jones, Jeannot Fréjus Zinsou, Josiane Honkpehedji, Ayola Akim Adegnika, Jean-Claude Dejon Agobe, Marguerite Massinga-Loembe, Benjamin Mordmüller, Teun Bousema, Maria Yazdanbakhsh
Infections with helminths and Plasmodium spp. overlap in their geographical distribution. It has been postulated that helminth infections may influence malarial transmission by altering Plasmodium falciparum gametocytogenesis. This cross-sectional study assessed the effect of helminth infections on P. falciparum gametocyte carriage and on humoral immune responses to sexual stage antigens in Gabon. Schistosoma haematobium and filarial infections as well as P. falciparum asexual forms and gametocyte carriage were determined...
August 3, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27270389/vector-borne-pathogens-in-dogs-and-red-foxes-from-the-federal-state-of-brandenburg-germany
#10
Jana M Liesner, Jürgen Krücken, Roland Schaper, Stefan Pachnicke, Barbara Kohn, Elisabeth Müller, Christoph Schulze, Georg von Samson-Himmelstjerna
Dirofilaria repens is endemic in eastern and southern European regions but was recently found in Germany in dogs, mosquitoes and one human patient. Since some of the positive dog and mosquito samples were collected in Brandenburg, it was aimed to systematically assess the prevalence of D. repens and other canine vector-borne pathogens in Brandenburg. Dog owners also received a questionnaire and were asked to provide more information about the dogs including travel history. In total, 1023 dog blood samples as well as 195 fox spleen and 179 fox blood samples were collected...
July 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27174667/rhizome-extracts-of-curcuma-zedoaria-rosc-induce-caspase-dependant-apoptosis-via-generation-of-reactive-oxygen-species-in-filarial-parasite-setaria-digitata-in%C3%A2-vitro
#11
K S Senathilake, E H Karunanayake, S R Samarakoon, K H Tennekoon, E D de Silva
Human lymphatic filariasis (LF) is mainly caused by filarial parasite Wuchereria bancrofti and is the second leading cause of long term and permanent disability in tropical countries. To date, incapability to eliminate long lived adult parasites by current drugs remains the major challenge in the elimination of LF. Hence, in the current study, the efficacy of rhizome extracts of Curcuma zedoaria (a plant traditionally used in Sri Lanka in the management of LF) was evaluated as an effective filaricide in vitro...
August 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27163575/occurrence-of-mansonella-ozzardi-diagnosed-using-a-polycarbonate-membrane-in-a-riverside-population-of-l%C3%A3-brea-in-the-western-brazilian-amazon
#12
Sergio de Almeida Basano, Jansen Fernandes Medeiros, Gilberto Fontes, Gabriel de Deus Vieira, Juliana Souza de Almeida Aranha Camargo, Luana Janaína Souza Vera, Ricardo de Godoi Mattos Ferreira, Luís Marcelo Aranha Camargo
INTRODUCTION Mansonella ozzardi is a widely distributed filaria worm in the Amazon region. This study aimed to determine the prevalence of M. ozzardi infection in riverine communities of Lábrea municipality, Amazonas State, Brazil. METHODS A diagnostic blood filtration method in a polycarbonate membrane was used. RESULTS M. ozzardi was found in 50.3% of the sample, with the highest prevalence in farmers/fishermen (69.4%; χ 2 = -19.14, p<0.001). The prevalence was higher in longer-term residents (≥11 years; 60...
February 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27160085/molecular-detection-of-leishmania-infantum-filariae-and-wolbachia-spp-in-dogs-from-southern-portugal
#13
Carla Maia, Laura Altet, Lorena Serrano, José Manuel Cristóvão, Maria Dolores Tabar, Olga Francino, Luís Cardoso, Lenea Campino, Xavier Roura
BACKGROUND: Leishmaniosis caused by the protozoan Leishmania infantum and dirofilariosis caused by the nematodes Dirofilaria immitis or Dirofilaria repens are vector-borne zoonoses widely present in the Mediterranean basin. In addition, some studies reported that the endosymbiont Wolbachia spp. play a role in the biology and pathogenesis of filarial parasites. The aim of this work was to evaluate the frequency of mono- and co-infections by L. infantum, filariae and Wolbachia spp. and their association with clinical signs in dogs from the south of Portugal...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27151313/further-evidence-of-the-cross-reactivity-of-the-binax-now%C3%A2-filariasis-ict-cards-to-non-wuchereria-bancrofti-filariae-experimental-studies-with-loa-loa-and-onchocerca-ochengi
#14
Samuel Wanji, Nathalie Amvongo-Adjia, Abdel Jelil Njouendou, Jonas Arnaud Kengne-Ouafo, Winston Patrick Chounna Ndongmo, Fanny Fri Fombad, Benjamin Koudou, Peter A Enyong, Moses Bockarie
BACKGROUND: The immunochromatographic test (ICT) for lymphatic filariasis is a serological test designed for unequivocal detection of circulating Wuchereria bancrofti antigen. It was validated and promoted by WHO as the primary diagnostic tool for mapping and impact monitoring for disease elimination following interventions. The initial tests for specificity and sensitivity were based on samples collected in areas free of loiasis and the results suggested a near 100% specificity for W...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27145083/an-in-vitro-in-vivo-model-to-analyze-the-effects-of-flubendazole-exposure-on-adult-female-brugia-malayi
#15
Maeghan O'Neill, Abdelmoneim Mansour, Utami DiCosty, James Geary, Michael Dzimianski, Scott D McCall, John W McCall, Charles D Mackenzie, Timothy G Geary
Current control strategies for onchocerciasis and lymphatic filariasis (LF) rely on prolonged yearly or twice-yearly mass administration of microfilaricidal drugs. Prospects for near-term elimination or eradication of these diseases would be improved by availability of a macrofilaricide that is highly effective in a short regimen. Flubendazole (FLBZ), a benzimidazole anthelmintic registered for control of human gastrointestinal nematode infections, is a potential candidate for this role. FLBZ has profound and potent macrofilaricidal effects in many experimental animal models of filariases and in one human trial for onchocerciasis after parental administration...
May 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27111140/neutropenic-mice-provide-insight-into-the-role-of-skin-infiltrating-neutrophils-in-the-host-protective-immunity-against-filarial-infective-larvae
#16
Nicolas Pionnier, Emilie Brotin, Gregory Karadjian, Patrice Hemon, Françoise Gaudin-Nomé, Nathaly Vallarino-Lhermitte, Adélaïde Nieguitsila, Frédéric Fercoq, Marie-Laure Aknin, Viviana Marin-Esteban, Sylvie Chollet-Martin, Géraldine Schlecht-Louf, Françoise Bachelerie, Coralie Martin
Our knowledge and control of the pathogenesis induced by the filariae remain limited due to experimental obstacles presented by parasitic nematode biology and the lack of selective prophylactic or curative drugs. Here we thought to investigate the role of neutrophils in the host innate immune response to the infection caused by the Litomosoides sigmodontis murine model of human filariasis using mice harboring a gain-of-function mutation of the chemokine receptor CXCR4 and characterized by a profound blood neutropenia (Cxcr4(+/1013))...
April 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27094256/dirofilaria-repens-emergence-of-autochthonous-human-infections-in-the-czech-republic-case-reports
#17
Jana Matějů, Marta Chanová, David Modrý, Barbora Mitková, Kristýna Hrazdilová, Víta Žampachová, Libuše Kolářová
BACKGROUND: Human dirofilariasis is a zoonotic infection that continues to spread to previously unaffected areas of Europe. In the South Moravian Region of the Czech Republic (CR), imported as well as autochthonous canine infections were recorded in the last decade, and parasite DNA was detected in mosquitoes of Aedes vexans. In the present paper, human Dirofilaria infections are reported from the country for the first time. CASE PRESENTATION: The samples from five patients with suspected tissue helminthiases were investigated...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27069790/breakdown-of-coevolution-between-symbiotic-bacteria-wolbachia-and-their-filarial-hosts
#18
Emilie Lefoulon, Odile Bain, Benjamin L Makepeace, Cyrille d'Haese, Shigehiko Uni, Coralie Martin, Laurent Gavotte
Wolbachia is an alpha-proteobacterial symbiont widely distributed in arthropods. Since the identification of Wolbachia in certain animal-parasitic nematodes (the Onchocercidae or filariae), the relationship between arthropod and nematode Wolbachia has attracted great interest. The obligate symbiosis in filariae, which renders infected species susceptible to antibiotic chemotherapy, was held to be distinct from the Wolbachia-arthropod relationship, typified by reproductive parasitism. While co-evolutionary signatures in Wolbachia-arthropod symbioses are generally weak, reflecting horizontal transmission events, strict co-evolution between filariae and Wolbachia has been reported previously...
2016: PeerJ
https://www.readbyqxmd.com/read/27008279/pyrosequencing-using-sl-and-5s-rrna-as-molecular-markers-for-identifying-zoonotic-filarial-nematodes-in-blood-samples-and-mosquitoes
#19
Oranuch Sanpool, Chairat Tantrawatpan, Tongjit Thanchomnang, Penchom Janwan, Pewpan M Intapan, Rutchanee Rodpai, Viraphong Lulitanond, Piyanan Taweethavonsawat, Wanchai Maleewong
BACKGROUNDS: Lymphatic filariasis is principally caused by Wuchereria bancrofti, and Brugia malayi. The other two filarial nematode species, Brugia pahangi and Dirofilaria immitis, possibly cause human zoonotic diseases. METHODS: We propose the development of a PCR assay linked with DNA pyrosequencing as a rapid tool to identify W. bancrofti, B. malayi, B. pahangi, and D. immitis in blood samples and mosquitoes. Primers targeting the fragment of the 5S ribosomal RNA and spliced leader sequences were newly designed and developed to identify these four filarial nematodes...
May 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27008189/first-report-of-filaria-martis-gmelin-1790-in-the-european-mink-mustela-lutreola-linnaeus-1761
#20
Jordi Torres, Jordi Miquel, Christine Fournier-Chambrillon, Adrien André, Fermín Urra Maya, Gloria Giralda Carrera, Pascal Fournier
The riparian European mink (Mustela lutreola), currently surviving in only three unconnected sites in Europe, is now listed as a critically endangered species according to the IUCN. Habitat loss and degradation, anthropic mortality, interaction with the feral American mink (Neovison vison), and infectious diseases are among the principal causes of its decline. Surveys of helminth parasites of this host that also include focus on subcutaneous potentially pathogenic helminths such as those belonging to the genus Filaria are very scarce...
June 2016: Parasitology Research
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