keyword
https://read.qxmd.com/read/38420884/real-world-safety-and-efficacy-of-lomitapide-in-homozygous-familial-hypercholesterolemia-interim-report-of-special-use-survey-in-japan
#21
JOURNAL ARTICLE
Mariko Harada-Shiba, Shigenori Haruna, Noriaki Kogawa
Aim: To evaluate the safety and efficacy of lomitapide in real-world clinical practice in Japan. Patients & methods: Interim analysis of 39 patients with homozygous familial hypercholesterolemia from an all-case surveillance study. Results: Median lomitapide dose (across 42 months) was 9.8 mg/day. 74 drug-related adverse events (AEs) were reported in 24 (61.5%) patients, including 14 (35.9%) with liver-related AEs, 19 (48.7%) with gastrointestinal disorders and 1 (2.6%) bleeding disorder. Lomitapide dose was reduced for 39...
February 29, 2024: Future Cardiology
https://read.qxmd.com/read/38420755/proteomic-associations-of-adverse-outcomes-in-human-heart-failure
#22
JOURNAL ARTICLE
Marie-Joe Dib, Michael G Levin, Lei Zhao, Ahmed Diab, Zhaoqing Wang, Christina Ebert, Oday Salman, Joe David Azzo, Sushrima Gan, Payman Zamani, Jordana B Cohen, Dipender Gill, Stephen Burgess, Loukas Zagkos, Vanessa van Empel, A Mark Richards, Rob Doughty, Ernst R Rietzschel, Karl Kammerhoff, Erika Kvikstad, Joseph Maranville, Peter Schafer, Dietmar A Seiffert, Francisco Ramirez-Valle, David A Gordon, Ching-Pin Chang, Ali Javaheri, Douglas L Mann, Thomas P Cappola, Julio A Chirinos
BACKGROUND: Identifying novel molecular drivers of disease progression in heart failure (HF) is a high-priority goal that may provide new therapeutic targets to improve patient outcomes. The authors investigated the relationship between plasma proteins and adverse outcomes in HF and their putative causal role using Mendelian randomization. METHODS AND RESULTS: The authors measured 4776 plasma proteins among 1964 participants with HF with a reduced left ventricular ejection fraction enrolled in PHFS (Penn Heart Failure Study)...
February 29, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38402906/perspectives-on-the-success-of-plasma-lipidomics-in-cardiovascular-drug-discovery-and-future-challenges
#23
JOURNAL ARTICLE
Timothy Abrahams, Stephen J Nicholls
INTRODUCTION: Plasma lipidomics has emerged as a powerful tool in cardiovascular drug discovery by providing insights into disease mechanisms, identifying potential biomarkers for diagnosis and prognosis, and discovering novel targets for drug development. Widespread application of plasma lipidomics is hampered by technological limitations and standardization and requires a collaborative approach to maximize its use in cardiovascular drug discovery. AREAS COVERED: This review provides an overview of the utility of plasma lipidomics in cardiovascular drug discovery and discusses the challenges and future perspectives of this rapidly evolving field...
March 2024: Expert Opinion on Drug Discovery
https://read.qxmd.com/read/38401179/atf6-protects-against-protein-misfolding-during-cardiac-hypertrophy
#24
JOURNAL ARTICLE
Christoph Hofmann, Marjan Aghajani, Cecily D Alcock, Erik A Blackwood, Clara Sandmann, Nicole Herzog, Julia Groß, Lars Plate, R Luke Wiseman, Randal J Kaufman, Hugo A Katus, Tobias Jakobi, Mirko Völkers, Christopher C Glembotski, Shirin Doroudgar
Cardiomyocytes activate the unfolded protein response (UPR) transcription factor ATF6 during pressure overload-induced hypertrophic growth. The UPR is thought to increase ER protein folding capacity and maintain proteostasis. ATF6 deficiency during pressure overload leads to heart failure, suggesting that ATF6 protects against myocardial dysfunction by preventing protein misfolding. However, conclusive evidence that ATF6 prevents toxic protein misfolding during cardiac hypertrophy is still pending. Here, we found that activation of the UPR, including ATF6, is a common response to pathological cardiac hypertrophy in mice...
February 23, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38395296/gut-microbial-metabolite-trimethylamine-n-oxide-induces-aortic-dissection
#25
JOURNAL ARTICLE
Shan Huang, Shijuan Gao, Yihui Shao, Ping Li, Jie Lu, Ke Xu, Zeyi Zhou, Yulin Li, Jie Du
Aortic dissection (AD) is the most catastrophic vascular disease with a high mortality rate. Trimethylamine N-oxide (TMAO), a gut microbial metabolite, has been implicated in the pathogenesis of cardiovascular diseases. However, the role of TMAO in AD and the underlying mechanisms remain unclear. This study aimed to explore the effects of TMAO on AD. Plasma and fecal samples from patients with AD and healthy individuals were collected to analyze TMAO levels and gut microbial species, respectively. The plasma levels of TMAO were significantly higher in 253 AD patients compared with those in 98 healthy subjects (3...
February 21, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38390810/-how-to-release-or-not-release-that-is-the-question-a-review-of-interleukin-1-cellular-release-mechanisms-in-vascular-inflammation
#26
REVIEW
Evan Kidder, Siddhartha Gangopadhyay, Sheila Francis, Mabruka Alfaidi
Cardiovascular disease remains the leading cause of death worldwide, characterized by atherosclerotic activity within large and medium-sized arteries. Inflammation has been shown to be a primary driver of atherosclerotic plaque formation, with interleukin-1 (IL-1) having a principal role. This review focuses on the current state of knowledge of molecular mechanisms of IL-1 release from cells in atherosclerotic plaques. A more in-depth understanding of the process of IL-1's release into the vascular environment is necessary for the treatment of inflammatory disease processes, as the current selection of medicines being used primarily target IL-1 after it has been released...
February 23, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38387723/cannabidiol-protects-against-acute-aortic-dissection-by-inhibiting-macrophage-infiltration-and-pmaip1-induced-vascular-smooth-muscle-cell-apoptosis
#27
JOURNAL ARTICLE
Yilong Guo, Yang Che, Xuelin Zhang, Zongna Ren, Yinan Chen, Liliang Guo, Lin Mao, Ren Wei, Xiang Gao, Tao Zhang, Li Wang, Wei Guo
Acute aortic dissection (AAD) progresses rapidly and is associated with high mortality; therefore, there remains an urgent need for pharmacological agents that can protect against AAD. Herein, we examined the therapeutic effects of cannabidiol (CBD) in AAD by establishing a suitable mouse model. In addition, we performed human AAD single-cell RNA sequencing and mouse AAD bulk RNA sequencing to elucidate the potential underlying mechanism of CBD. Pathological assays and in vitro studies were performed to verify the results of the bioinformatic analysis and explore the pharmacological function of CBD...
February 20, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38387309/neutrophils-are-indispensable-for-adverse-cardiac-remodeling-in-heart-failure
#28
JOURNAL ARTICLE
Sergey Antipenko, Nicolas Mayfield, Miki Jinno, Matthias Gunzer, Mohamed Ameen Ismahil, Tariq Hamid, Sumanth D Prabhu, Gregg Rokosh
Persistent immune activation contributes significantly to left ventricular (LV) dysfunction and adverse remodeling in heart failure (HF). In contrast to their well-known essential role in acute myocardial infarction (MI) as first responders that clear dead cells and facilitate subsequent reparative macrophage polarization, the role of neutrophils in the pathobiology of chronic ischemic HF is poorly defined. To determine the importance of neutrophils in the progression of ischemic cardiomyopathy, we measured their production, levels, and activation in a mouse model of chronic HF 8 weeks after permanent coronary artery ligation and large MI...
February 21, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38385329/plain-language-summary-of-the-safety-and-effectiveness-of-etripamil-for-atrioventricular-nodal-dependent-supraventricular-tachycardia-the-rapid-study
#29
REVIEW
James E Ip, Bruce S Stambler, David B Bharucha, Annette Green
WHAT IS THIS SUMMARY ABOUT?: This is a plain language summary of a clinical research study called RAPID. The study looked at the potential for how safe and effective etripamil was at stopping an episode of rapid heartbeats in people with atrioventricularnodal-dependent supraventricular tachycardia (AV-node-dependent SVT). An episode is used to describe the period of time when a person experiences an abnormally very fast heartbeat. This was done by comparing an investigational drug called etripamil with a placebo, each administered via a rapidly acting nasal spray...
February 22, 2024: Future Cardiology
https://read.qxmd.com/read/38382580/the-associations-among-peptic-ulcer-disease-helicobacter-pylori-infection-and-abdominal-aortic-aneurysms-a-nationwide-population-based-cohort-study
#30
JOURNAL ARTICLE
Chia-Wei Hong, Hsiao-Ya Tsai, Chi-Hsiang Chung, Jen-Chun Wang, Yu-Juei Hsu, Chih-Yuan Lin, Chin-Wang Hsu, Wu-Chien Chien, Shih-Hung Tsai
BACKGROUND: There are overlapping risk factors and underlying molecular mechanisms for both peptic ulcer disease (PUD) and abdominal aortic aneurysm (AAA). Despite improvements in the early diagnosis and treatment of AAA, ruptured AAAs continue to cause a substantial number of deaths. Helicobacter pylori are Gram-negative, microaerophilic bacteria that are now recognized as the main cause of PUD. H. pylori infection (HPI) is associated with an increased risk of certain cardiovascular diseases...
February 20, 2024: Journal of Cardiology
https://read.qxmd.com/read/38382296/novel-roles-of-cardiac-derived-erythropoietin-in-cardiac-development-and-function
#31
JOURNAL ARTICLE
Melissa A Allwood, Brittany A Edgett, Mathew J Platt, Jade P Marrow, Bridget Coyle-Asbil, Emma J B Holjak, Victoria L Nelson, Swara Bangali, Razan Alshamali, Kathy Jacyniak, Jorden M Klein, Laura Farquharson, Nadya Romanova, Victoria Northrup, Leslie M Ogilvie, Anmar Ayoub, Kjetil Ask, Matthew K Vickaryous, Gregory M T Hare, Keith R Brunt, Jeremy A Simpson
The role of erythropoietin (EPO) has extended beyond hematopoiesis to include cytoprotection, inotropy, and neurogenesis. Extra-renal EPO has been reported for multiple tissue/cell types, but the physiological relevance remains unknown. Although the EPO receptor is expressed by multiple cardiac cell types and human recombinant EPO increases contractility and confers cytoprotection against injury, whether the heart produces physiologically meaningful amounts of EPO in vivo is unclear. We show a distinct circadian rhythm of cardiac EPO mRNA expression in adult mice and increased mRNA expression during embryogenesis, suggesting physiological relevance to cardiac EPO production throughout life...
February 20, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38369209/topic-precision-medicine-approaches-in-cardiology-personalized-therapies-for-improved-patient-outcomes-a-systematic-review
#32
REVIEW
Hyma Bamba, Gurmehar Singh, Jobby John, Pugazhendi Inban, Priyadarshi Prajjwal, Haitham Alhussain, Mohammed Dheyaa Marsool Marsool
Personalized medicine is a novel and rapidly evolving approach to clinical practice that involves making decisions about disease prediction, prevention, diagnosis, and treatment by utilizing modern technologies. The concepts of precision medicine have grown as a result of ongoing developments in genomic analysis, molecular diagnostics, and technology. These advancements have enabled a deeper understanding and interpretation of the human genome, allowing for a personalized approach to clinical care. The primary objective of this research is to assess personalized medicine in terms of its indications, advantages, practical clinical uses, potential future directions, problems, and effects on healthcare...
February 16, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38364731/exercise-reduces-pro-inflammatory-lipids-and-preserves-r-esolution-mediators-that-calibrate-macrophage-centric-immune-metabolism-in-spleen-and-heart-following-obesogenic-diet-in-aging-mice
#33
JOURNAL ARTICLE
Ganesh V Halade, Gunjan Upadhyay, MathanKumar Marimuthu, Xuan Wanling, Vasundhara Kain
The study investigated the role of volunteer exercise and an obesogenic diet (OBD) in mice, focusing on the splenocardiac axis and inflammation-resolution signaling. Male C57BL/6J mice (2 months old) were assigned to control (CON) or OBD groups for ten months, then randomized into sedentary (Sed) or exercise (Exe) groups for two weeks. Leukocytes, heart function, structure, and spleen tissue examined for inflammation-resolution mediators and macrophage-centric gene transcripts. After two weeks of volunteer exercise, cardiac function shows limited changes, but structural changes were notable in the heart and spleen...
February 14, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38363615/the-iaam-ltbp4-haplotype-is-protective-against-dystrophin-deficient-cardiomyopathy
#34
JOURNAL ARTICLE
Luca Bello, Daniele Sabbatini, Aurora Fusto, Domenico Gorgoglione, Giovanni Umberto Borin, Martina Penzo, Pietro Riguzzi, Matteo Villa, Sara Vianello, Chiara Calore, Paola Melacini, Riccardo Vio, Andrea Barp, Grazia D'Angelo, Sandra Gandossini, Luisa Politano, Angela Berardinelli, Sonia Messina, Gian Luca Vita, Marina Pedemonte, Claudio Bruno, Emilio Albamonte, Valeria Sansone, Giovanni Baranello, Riccardo Masson, Guja Astrea, Adele D'Amico, Enrico Bertini, Marika Pane, Simona Lucibello, Eugenio Mercuri, Christopher Spurney, Paula Clemens, Lauren Morgenroth, Heather Gordish-Dressman, Craig M McDonald, Eric P Hoffman, Elena Pegoraro
BACKGROUND: Dilated cardiomyopathy (DCM) is a major complication of, and leading cause of mortality in Duchenne muscular dystrophy (DMD). Its severity, age at onset, and rate of progression display wide variability, whose molecular bases have been scarcely elucidated. Potential DCM-modifying factors include glucocorticoid (GC) and cardiological treatments, DMD mutation type and location, and variants in other genes. METHODS AND RESULTS: We retrospectively collected 3138 echocardiographic measurements of left ventricular ejection fraction (EF), shortening fraction (SF), and end-diastolic volume (EDV) from 819 DMD participants, 541 from an Italian multicentric cohort and 278 from the Cooperative International Neuromuscular Group Duchenne Natural History Study (CINRG-DNHS)...
February 16, 2024: Journal of Neuromuscular Diseases
https://read.qxmd.com/read/38360101/potential-regulatory-role-of-epigenetic-modifications-in-aging-related-heart-failure
#35
JOURNAL ARTICLE
Lin Lv, Qiuyu Chen, Jing Lu, Qi Zhao, HongYan Wang, JiaHao Li, KeYing Yuan, ZengXiang Dong
Heart failure (HF) is a serious clinical syndrome and a serious development or advanced stage of various heart diseases. Aging is an independent factor that causes pathological damage in cardiomyopathy and participates in the occurrence of HF at the molecular level by affecting mechanisms such as telomere shortening and mitochondrial dysfunction. Epigenetic changes have a significant impact on the aging process, and there is increasing evidence that genetic and epigenetic changes are key features of aging and aging-related diseases...
February 13, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38360096/variable-clinical-expression-of-a-novel-flnc-truncating-variant-in-a-large-family
#36
JOURNAL ARTICLE
Orr Tomer, Smadar Horowitz-Cederboim, Dini Rivkin, Vardiella Meiner, Michael H Gollob, Donna R Zwas, Ronen Durst, Ayelet Shauer
BACKGROUND: Variants in Filamin-C (FLNC) have been associated with various hereditary cardiomyopathies. Recent literature reports a prevalence of sudden cardiac death (SCD) of 13-25% among carriers of truncating-variants, with mean age of 42±15 years for first SCD event. This study reports two familial cases of SCD and the results of cascade screening of their large family. METHODS: Molecular-autopsy of the SCD victims revealed a novel truncating-variant in the FLNC gene (chr 7:128496880 [hg19]; NM_001458...
February 13, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38359551/ncor1-limits-angiogenic-capacity-by-altering-notch-signaling
#37
JOURNAL ARTICLE
Tom Teichmann, Pedro Malacarne, Simonida Zehr, Stefan Günther, Beatrice Pflüger-Müller, Timothy Warwick, Ralf P Brandes
Corepressors negatively regulate gene expression by chromatin compaction. Targeted regulation of gene expression could provide a means to control endothelial cell phenotype. We hypothesize that by targeting corepressor proteins, endothelial angiogenic function can be improved. To study this, the expression and function of nuclear corepressors in human umbilical vein endothelial cells (HUVEC) and in murine organ culture was studied. RNA-seq revealed that nuclear receptor corepressor 1 (NCoR1), silencing mediator of retinoid and thyroid hormone receptors (SMRT) and repressor element-1 silencing transcription factor (REST) are the highest expressed corepressors in HUVECs...
February 14, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38358608/understanding-the-genetic-and-non-genetic-interconnections-in-the-aetiology-of-syndromic-congenital-heart-disease-an-updated-review-part-2
#38
REVIEW
Jyoti Maddhesiya, Bhagyalaxmi Mohapatra
PURPOSE OF REVIEW: Approximately 30% of syndromic cases diagnosed with CHD, which lure us to further investigate the molecular and clinical challenges behind syndromic CHD (sCHD). The aetiology of sCHD in a majority of cases remains enigmatic due to involvement of multiple factors, namely genetic, epigenetic and environmental modifiable risk factors for the development of the disease. Here, we aim to update the role of genetic contributors including chromosomal abnormalities, copy number variations (CNVs) and single gene mutations in cardiac specific genes, maternal lifestyle conditions, environmental exposures and epigenetic modifiers in causing CHD in different genetic syndromes...
February 15, 2024: Current Cardiology Reports
https://read.qxmd.com/read/38355242/intrahepatic-transcriptomics-differentiate-advanced-fibrosis-and%C3%A2-clinical-outcomes-in-adults-with%C3%A2-fontan-circulation
#39
JOURNAL ARTICLE
Katia Bravo-Jaimes, Xiuju Wu, Leigh C Reardon, Gentian Lluri, Jeannette P Lin, Jeremy P Moore, Glen van Arsdell, Reshma Biniwale, Ming-Sing Si, Bita V Naini, Robert Venick, Sammy Saab, Christopher L Wray, Reid Ponder, Carl Rosenthal, Alexandra Klomhaus, Kristina I Böstrom, Jamil A Aboulhosn, Fady M Kaldas
BACKGROUND: The molecular mechanisms underlying Fontan-associated liver disease (FALD) remain largely unknown. OBJECTIVES: This study aimed to assess intrahepatic transcriptomic differences among patients with FALD according to the degree of liver fibrosis and clinical outcomes. METHODS: This retrospective cohort study included adults with the Fontan circulation. Baseline clinical, laboratory, imaging, and hemodynamic data as well as a composite clinical outcome (CCO) were extracted from medical records...
February 20, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38354947/risks-and-benefits-of-intermittent-fasting-for-the-aging-cardiovascular-system
#40
REVIEW
Mualla Ozcan, Mahmoud Abdellatif, Ali Javaheri, Simon Sedej
Population aging and the associated increase in cardiovascular disease rates pose serious threats to global public health. Different forms of fasting have become an increasingly attractive strategy to directly address aging and potentially limit or delay the onset of cardiovascular diseases. A growing number of experimental studies and clinical trials indicate that the amount and timing of food intake as well as the daily time window during which food is consumed, are crucial determinants of cardiovascular health...
February 12, 2024: Canadian Journal of Cardiology
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