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Molecular cardiology

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https://www.readbyqxmd.com/read/27914009/serum-response-factor-srf-ablation-interferes-with-acute-stress-associated-immediate-and-long-term-coping-mechanisms
#1
Annemarie Zimprich, Gabi Mroz, Christopher Meyer Zu Reckendorf, Sofia Anastasiadou, Philip Förstner, Lillian Garrett, Sabine M Hölter, Lore Becker, Jan Rozman, Cornelia Prehn, Birgit Rathkolb, Kristin Moreth, Wolfgang Wurst, Thomas Klopstock, Martin Klingenspor, Jerzy Adamski, Eckhard Wolf, Raffi Bekeredjian, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Bernd Knöll
Stress experience modulates behavior, metabolism, and energy expenditure of organisms. One molecular hallmark of an acute stress response is a rapid induction of immediate early genes (IEGs) such as c-Fos and Egr family members. IEG transcription in neurons is mediated by the neuronal activity-driven gene regulator serum response factor (SRF). We show a first role of SRF in immediate and long-lasting acute restraint stress (AS) responses. For this, we employed a standardized mouse phenotyping protocol at the German Mouse Clinic (GMC) including behavioral, metabolic, and cardiologic tests as well as gene expression profiling to analyze the consequences of forebrain-specific SRF deletion in mice exposed to AS...
December 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27858404/advances-in-multimodal-molecular-imaging
#2
Luigi Auletta, Matteo Gramanzini, Gargiulo Sara, Sandra Albanese, Marco Salvatore, Adelaide Greco
INTRODUCTION: Preclinical molecular imaging is an emerging field. Improving the ability of scientists to study the molecular basis of human pathology in animals is of the utmost importance for future advances in all fields of human medicine. Moreover, the possibility of developing new imaging techniques or of implementing old ones adapted to the clinic is a significant area. EVIDENCE ACQUISITION: Cardiology, neurology, immunology and oncology have all been studied with preclinical molecular imaging...
November 18, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27830433/erratum-to-american-society-of-nuclear-cardiology-and-society-of-nuclear-medicine-and-molecular-imaging-joint-position-statement-on-the-clinical-indications-for-myocardial-perfusion-pet
#3
Timothy M Bateman, Vasken Dilsizian, Rob S Beanlands, E Gordon DePuey, Gary V Heller, David A Wolinsky
No abstract text is available yet for this article.
November 9, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27781062/pentraxin-3-ptx3-promoter-methylation-associated-with-ptx3-plasma-levels-and-neutrophil-to-lymphocyte-ratio-in-coronary-artery-disease
#4
Tang-Meng Guo, Li-Li Huang, Kai Liu, Li Ke, Zhi-Jian Luo, Yun-Qiao Li, Xing-Lin Chen, Bei Cheng
BACKGROUND: Pentraxin 3 (PTX3) is expressed in the heart under inflammatory conditions and plays an important role in atherogenesis. Patients with increased PTX3 levels may suffer from higher rates of cardiac events. Regulation of specific genes by promoter methylation is important in atherogenesis. The factors influencing PTX3 levels and the association between epigenetics and PTX3 levels have not been investigated. METHODS: Blood samples were collected from 64 patients admitted to the Department of Cardiology, 35 who had coronary artery disease (CAD), and 29 who were CAD-free...
August 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27759832/preclinical-molecular-imaging-development-of-instrumentation-for-translational-research-with-small-laboratory-animals
#5
Jorge Mejia, Ana Claudia Camargo Miranda, Ana Claudia Ranucci Durante, Larissa Rolim de Oliveira, Marycel Rosa Felisa Figols de Barboza, Katerin Taboada Rosell, Daniele Pereira Jardim, Alexandre Holthausen Campos, Marilia Alves Dos Reis, Marcela Forli Catanoso, Orfa Yineth Galvis-Alonso, Francisco Romero Cabral
Objective: To present the result of upgrading a clinical gamma-camera to be used to obtain in vivo tomographic images of small animal organs, and its application to register cardiac, renal and neurological images. Methods: An updated version of the miniSPECT upgrading device was built, which is composed of mechanical, electronic and software subsystems. The device was attached to a Discovery VH (General Electric Healthcare) gamma-camera, which was retired from the clinical service and installed at the Centro de Imagem Pré-Clínica of the Hospital Israelita Albert Einstein...
July 2016: Einstein
https://www.readbyqxmd.com/read/27659455/pet-mr-yet-another-tesla
#6
Markus Schwaiger, Karl Kunze, Christoph Rischpler, Stephan G Nekolla
After the successful introduction of PET/CT as a multimodality imaging technique, PET/MR has subsequently emerged as an attractive instrumentation for applications in neurology, oncology, and cardiology. Simultaneous data acquisition combining structural, functional, and molecular imaging provides a unique platform to link various aspects of cardiac performance for the non-invasive characterization of cardiovascular disease phenotypes. Specifically, tissue characterization by MR techniques with and without contrast agents allows for functional parameters such as LGE, myocardial perfusion, and T1 maps as well as an estimate of extracellular volume...
September 22, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27617263/the-role-of-genetic-testing-in-the-identification-of-young-athletes-with-inherited-primitive-cardiac-disorders-at-risk-of-exercise-sudden-death
#7
REVIEW
Francesco Danilo Tiziano, Vincenzo Palmieri, Maurizio Genuardi, Paolo Zeppilli
Although relatively rare, inherited primitive cardiac disorders (IPCDs) in athletes have a deep social impact since they often present as sudden cardiac death (SCD) of young and otherwise healthy persons. The diagnosis of these conditions is likely underestimated due to the lack of shared clinical criteria and to the existence of several borderline clinical pictures. We will focus on the clinical and molecular diagnosis of the most common IPCDs, namely hypertrophic cardiomyopathies, long QT syndrome, arrhythmogenic right ventricular cardiomyopathy, and left ventricular non-compaction...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27562837/natural-history-and-life-threatening-complications-in-myhre-syndrome-and-review-of-the-literature
#8
Livia Garavelli, Ilenia Maini, Federica Baccilieri, Ivan Ivanovski, Marzia Pollazzon, Simonetta Rosato, Lorenzo Iughetti, Sheila Unger, Andrea Superti-Furga, Marco Tartaglia
UNLABELLED: Myhre syndrome (OMIM 139210) is a rare developmental disorder inherited as an autosomal dominant trait and caused by a narrow spectrum of missense mutations in the SMAD4 gene. The condition features characteristic face, short stature, skeletal anomalies, muscle pseudohypertrophy, restricted joint mobility, stiff and thick skin, and variable intellectual disability. While most of the clinical features manifest during childhood, the diagnosis may be challenging during the first years of life...
October 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27544700/structural-alterations-induced-by-ten-disease-causing-mutations-of-human-dihydrolipoamide-dehydrogenase-analyzed-by-hydrogen-deuterium-exchange-mass-spectrometry-implications-for-the-structural-basis-of-e3-deficiency
#9
Attila Ambrus, Junjie Wang, Reka Mizsei, Zsofia Zambo, Beata Torocsik, Frank Jordan, Vera Adam-Vizi
Pathogenic amino acid substitutions of the common E3 component (hE3) of the human alpha-ketoglutarate dehydrogenase and the pyruvate dehydrogenase complexes lead to severe metabolic diseases (E3 deficiency), which usually manifest themselves in cardiological and/or neurological symptoms and often cause premature death. To date, 14 disease-causing amino acid substitutions of the hE3 component have been reported in the clinical literature. None of the pathogenic protein variants has lent itself to high-resolution structure elucidation by X-ray or NMR...
November 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27539035/-management-of-cancer-patients-with-cardiovascular-complications-onco-cardiology
#10
Mikio Mukai
In Japan, cardiovascular diseases are frequent complications in cancer patients owing to the rapidly aging population and changes in the overall lifestyle. In addition, cancer itself including advanced cancer, and certain therapies used to treat it, often cause further cardiovascular complications. Moreover, although the recently developed molecularly targeted cancer drugs have improved patient prognosis, unexpected cardiovascular side effects, especially cardiotoxicity, have become an important limitation of cancer therapy...
August 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27535287/intracardiac-bone-cement-embolism-as-a-complication-of-vertebroplasty-management-strategy
#11
Catherine Hatzantonis, Marcin Czyz, Renata Pyzik, Bronek M Boszczyk
BACKGROUND: Vertebroplasty carries multiple complications due to the leakage of polymethylmethacrylate (PMMA) into the venous system through the iliolumbar or epidural veins. The rate of venous cement complications may vary from 1 to 10 %, with cement extravasation into the venous system in 24 % of patients. Emboli may further migrate into the right heart chambers and pulmonary arteries. Patients may vary in presentation from asymptomatic or symptoms such as syncope to life-threatening complications...
August 17, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27528255/american-society-of-nuclear-cardiology-and-society-of-nuclear-medicine-and-molecular-imaging-joint-position-statement-on-the-clinical-indications-for-myocardial-perfusion-pet
#12
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27521086/role-of-genetic-testing-in-patients-with-ventricular-arrhythmias-in-apparently-normal-hearts
#13
REVIEW
Nynke Hofman, Arthur A M Wilde
Ventricular arrhythmias without structural heart disease are responsible for ∼35% of patients who have sudden cardiac death before the age of 40 years. Molecular autopsy and/or cardiological investigation of nearby family members often reveals the diagnosis and genetic testing can be helpful in family screening and risk stratification in disease carriers. Extended gene panels can be screened in a short period of time at low cost. A multidisciplinary team of (genetically) specialized clinicians is necessary to judge all the available details and to decide on the significance of the variant and further strategies...
September 2016: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/27500929/in-vivo-cannulation-methods-for-cardiomyocytes-isolation-from-heart-disease-models
#14
Zhong Jian, Yi-Je Chen, Rafael Shimkunas, Yuwen Jian, Mark Jaradeh, Karen Chavez, Nipavan Chiamvimonvat, Jil C Tardiff, Leighton T Izu, Robert S Ross, Ye Chen-Izu
Isolation of high quality cardiomyocytes is critically important for achieving successful experiments in many cellular and molecular cardiology studies. Methods for isolating cardiomyocytes from the murine heart generally are time-sensitive and experience-dependent, and often fail to produce high quality cells. Major technical difficulties can be related to the surgical procedures needed to explant the heart and to cannulate the vessel to mount onto the Langendorff system before in vitro reperfusion can begin...
2016: PloS One
https://www.readbyqxmd.com/read/27264864/heparin-centenary-an-ever-young-life-saving-drug
#15
Giangiacomo Torri, Annamaria Naggi
On the centenary of the discovery of heparin, the International Journal of Cardiology agreed to publish a collection of mini reviews that summarize the historical development of this ever-young life-saving drug. The present articles deal not only with the historical milestones, but also with current and future perspectives regarding the development of heparin in terms of its structure, as well as on-going biochemical, biological and clinical research. Attention is focused on recent applications of heparin derivatives to non-anticoagulant or antithrombotic therapies, providing particular emphasis on their inhibitory activities, including their potential as anti-cancer agents...
June 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27213076/epicardial-fat-physiological-pathological-and-therapeutic-implications
#16
REVIEW
Juan Salazar, Eliana Luzardo, José Carlos Mejías, Joselyn Rojas, Antonio Ferreira, José Ramón Rivas-Ríos, Valmore Bermúdez
Epicardial fat is closely related to blood supply vessels, both anatomically and functionally, which is why any change in this adipose tissue's behavior is considered a potential risk factor for cardiovascular disease development. When proinflammatory adipokines are released from the epicardial fat, this can lead to a decrease in insulin sensitivity, low adiponectin production, and an increased proliferation of vascular smooth muscle cells. These adipokines move from one compartment to another by either transcellular passing or diffusion, thus having the ability to regulate cardiac muscle activity, a phenomenon called vasocrine regulation...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27197326/-whipple-disease-a-differential-diagnosis-of-polyarthritis-to-keep-in-mind
#17
Raphaël André, Benjamin Ehresmann, Jérôme Stirnemann, Jörg D Seebach
Whipple disease is a rare and potentially fatal bacterial infection induced by a Gram-positive bacillus, Tropheryma whipplei. It is responsible for articular, digestive, neurological, ophthalmological and cardiological symptoms that occur either concomitant or isolated. Thus, the diagnosis is difficult to make and therefore often delayed. A paradoxal exacerbation of the symptoms under immunosuppressive drugs such as glucocorticoids and anti-TNF mAb, or inexpected improvements under antibiotic treatment applied for other reasons should raise a clinicial suspicion of Whipple's disease...
April 6, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/27184919/18f-fdg-positron-emission-tomography-in-oncology-main-indications
#18
J L Vercher-Conejero, C Gámez Cenzano
The development of molecular and functional imaging with new imaging techniques such as computed tomography, magnetic resonance imaging, and positron emission tomography (PET) among others, has greatly improved the detection of tumors, tumor staging, and the detection of possible recurrences. Furthermore, the combination of these different imaging modalities and the continual development of radiotracers for PET have advanced our understanding and knowledge of the different pathophysiological processes in cancer, thereby helping to make treatment more efficacious, improving patients' quality of life, and increasing survival...
July 2016: Radiología
https://www.readbyqxmd.com/read/27155944/post-surgical-mediastinitis-due-to-carbapenem-resistant-enterobacteriaceae-clinical-epidemiological-and-survival-characteristics
#19
C S Abboud, J Monteiro, M E Stryjewski, E C Zandonadi, V Barbosa, D Dantas, E E Sousa, M J Fonseca, D M Jacobs, A C Pignatari, C Kiffer, G G Rao
Invasive infections due to carbapenem-resistant Enterobacteriaceae (CRE), including polymyxin-resistant (PR-CRE) strains, are being increasingly reported. However, there is a lack of clinical data for several life-threatening infections. Here we describe a cohort of patients with post-surgical mediastinitis due to CRE, including PR-CRE. This study was a retrospective cohort design at a single cardiology centre. Patients with mediastinitis due to CRE were identified and were investigated for clinically relevant variables...
May 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27103630/translational-and-emerging-clinical-applications-of-metabolomics-in-cardiovascular-disease-diagnosis-and-treatment
#20
REVIEW
Anthony C Dona, Sean Coffey, Gemma Figtree
Numerous molecular screening strategies have recently been developed to measure the chemical diversity of a population's biofluids with the ultimate aim to provide clinicians, medical scientists and epidemiologists with a clearer picture of the presence and severity of cardiovascular disease; prognosis; and response to treatment. Current cardiology practice integrates clinical history and examination with state-of-the-art imaging, invasive measures, and electrical interrogation. Biomarkers in common clinical use are relatively limited to troponin and brain natriuretic peptide, dependent on damage to heart muscle, or myocyte 'stretch' respectively...
October 2016: European Journal of Preventive Cardiology
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