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https://www.readbyqxmd.com/read/28719855/high-fat-diet-and-aging-interact-to-produce-neuroinflammation-and-impair-hippocampal-and-amygdalar-dependent-memory
#1
Sarah J Spencer, Heather D'Angelo, Alita Soch, Linda R Watkins, Steven F Maier, Ruth M Barrientos
More Americans are consuming diets higher in saturated fats and refined sugars than ever before, and based on increasing obesity rates, this is a growing trend among older adults as well. While high saturated fat diet (HFD) consumption has been shown to sensitize the inflammatory response to a subsequent immune challenge in young adult rats, the inflammatory effect of HFD in the already-vulnerable aging brain has not yet been assessed. Here, we explored whether short-term (3 days) consumption of HFD would serve as a neuroinflammatory trigger in aging animals, leading to cognitive deficits...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28719854/clinically-silent-alzheimer-s-and-vascular-pathologies-influence-brain-networks-supporting-executive-function-in-healthy-older-adults
#2
Brian T Gold, Christopher A Brown, Jonathan G Hakun, Leslie M Shaw, John Q Trojanowski, Charles D Smith
Aging is associated with declines in executive function. We examined how executive functional brain systems are influenced by clinically silent Alzheimer's disease (AD) pathology and cerebral white-matter hyperintensities (WMHs). Twenty-nine younger adults and 34 cognitively normal older adults completed a working memory paradigm while functional magnetic resonance imaging was performed. Older adults further underwent lumbar cerebrospinal fluid draw for the assessment of AD pathology and FLAIR imaging for the assessment of WMHs...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28719683/association-between-structured-physical-activity-and-sedentary-time-in-older-adults
#3
Amal A Wanigatunga, Walter T Ambrosius, W Jack Rejeski, Thomas M Gill, Nancy W Glynn, Catrine Tudor-Locke, Todd M Manini
No abstract text is available yet for this article.
July 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28719627/the-role-of-gender-in-the-association-between-self-rated-health-and-mortality-among-older-adults-in-santiago-chile-a-cohort-study
#4
Ximena Moreno, Cecilia Albala, Lydia Lera, Hugo Sánchez, Alejandra Fuentes-García, Alan D Dangour
BACKGROUND: Previous studies on the role of gender in the association between self-rated health and mortality have shown contrasting results. This study was aimed to determine the importance of gender in the association between self-rated health and mortality among older people in Santiago, Chile. METHODS: A 10 year follow-up of 1066 people aged 60 or more, from the Chilean cohort of the Study of Health, Ageing and Well-Being. Self-rated health was assessed in face to face interviews through a single general question, along with socio-demographic and health status information...
2017: PloS One
https://www.readbyqxmd.com/read/28719497/serologic-responses-in-childhood-pulmonary-tuberculosis
#5
Bareng A S Nonyane, Mark P Nicol, Nicholas J Andreas, Stefanie Rimmele, Nicole Schneiderhan-Marra, Lesley J Workman, Mark D Perkins, Thomas Joos, Tobias Broger, Jerrold J Ellner, David Alland, Beate Kampmann, Susan E Dorman, Heather J Zar
BACKGROUND: Identification of the Mycobacterium tuberculosis immunoproteome and antigens associated with serologic responses in adults has renewed interest in developing a serologic test for childhood tuberculosis (TB). We investigated IgG antibody responses against M. tuberculosis antigens in children with well-characterized TB. METHODS: We studied archived sera obtained from hospitalized children with suspected pulmonary TB, and classified as having confirmed TB (culture-confirmed), unlikely TB (clinical improvement without TB treatment), or unconfirmed TB (all others)...
July 15, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28718756/stereotypes-influence-destination-memory-in-normal-aging
#6
Mohamad El Haj
Background/Study Context: A substantial body of literature suggests that stereotypes can play a determining role in making judgments about the source of information. This study investigated this issue for destination memory or remembering to whom information has been previously told. METHODS: Younger adults and older adults told six medical and six mechanical facts to a picture depicting a physician, and also told six different medical and six different mechanical facts to a picture depicting a mechanic...
July 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28718755/preliminary-evidence-for-the-effects-of-aging-and-multiple-sclerosis-on-cognitive-performance-an-analysis-based-on-effect-size-estimates
#7
Rachel E Bollaert, Julia M Balto, Brian M Sandroff, Gioella Chaparro, Manuel E Hernandez, Robert W Motl
Background/Study Context: Although cognitive impairment is common in persons with multiple sclerosis (MS), there are limited data on older adults with MS. The current pilot study involved a preliminary examination of cognitive impairments across a comprehensive neuropsychological assessment in older adults with MS compared with older adults without MS. METHODS: Twenty older adults with MS and 20 older adults without MS (≥60 years of age) underwent cognitive assessments, including the Trail Making Test (TMT) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)...
July 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28718754/rhythmic-interlimb-coordination-impairments-are-associated-with-mobility-limitations-among-older-adults
#8
Eric G James, Suzanne G Leveille, Jeffrey M Hausdorff, Thomas Travison, Sarah Cote, Philip Conatser, Murat Karabulut, Andrea C Mendes, David N Kennedy, Katherine L Tucker, Soham Al Snih, Kyriakos S Markides, Jonathan F Bean
Background/Study Context: Mobility limitations affect more than 25% of adults aged 70 years or older. This study tested the hypothesis that impairments in ankle and shoulder coordination are associated with mobility limitations among older adults. METHODS: his study consisted of conducted a cross-sectional analysis from a sample of community-dwelling older adults (N = 130) aged ≥67 years. Motion capture equipment was used to collect kinematic data during rhythmic antiphase coordination of the right and left: (a) ankles moving in dorsi-plantarflexion; and (b) glenohumeral ("shoulder") moving in flexion-extension while paced by an auditory metronome...
July 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28718753/aging-and-list-wide-modulations-of-strategy-execution-a-study-in-arithmetic
#9
Thomas Hinault, Patrick Lemaire
Background/Study Context: This study aimed at further our understanding of the cognitive processes involved during strategy execution, and how the processes involved change with age. More specifically, the main goal was to investigate whether poorer-strategy effects (i.e., poorer performance when a cued strategy is not the best) and sequential modulations of poorer-strategy effects (i.e., decreased poorer-strategy effects on current problems following poorer-strategy problems compared with after better-strategy problems) are influenced by proportions of poorer-strategy problems...
July 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28718752/the-impact-of-presentation-format-on-younger-and-older-adults-self-regulated-learning
#10
Jodi Price
Background/Study Context: Self-regulated learning involves deciding what to study and for how long. Debate surrounds whether individuals' selections are influenced more by item complexity, point values, or if instead people select in a left-to-right reading order, ignoring item complexity and value. The present study manipulated whether point values and presentation format favored selection of simple or complex Chinese-English pairs to assess the impact on younger and older adults' selection behaviors. METHODS: One hundred and five younger (Mage = 20...
July 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28718751/aging-strikes-the-self-face-advantage-in-featural-processing
#11
Haoyue Qian, Zhiguo Wang, Lingyue Yan, Xiangping Gao
Background/Study Context: The face is the most distinctive physical feature of a person. Previous work has shown that one's own face (self-face) is advantageous in perception. Here the authors investigate how aging influences the configural and featural processing of self-face. METHODS: Older and young adults searched for their own faces and faces of strangers (Experiment 1) or acquaintances (Experiment 2) among distractor faces. The configural and featural processing of faces was assessed with face inversion in Experiment 1 and with changes in point of view in Experiment 2...
July 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28718325/collaborative-care-for-psychiatric-disorders-in-older-adults-a-systematic-review
#12
Pallavi Dham, Sarah Colman, Karen Saperson, Carrie McAiney, Lillian Lourenco, Nick Kates, Tarek K Rajji
OBJECTIVE: To evaluate the mode of implementation, clinical outcomes, cost-effectiveness, and the factors influencing uptake and sustainability of collaborative care for psychiatric disorders in older adults. DESIGN: Systematic review. SETTING: Primary care, home health care, seniors' residence, medical inpatient and outpatient. PARTICIPANTS: Studies with a mean sample age of 60 years and older. INTERVENTION: Collaborative care for psychiatric disorders...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28718299/felt-age-desired-and-expected-lifetime-in-the-context-of-health-well-being-and-successful-aging
#13
Neala Ambrosi-Randić, Marina Nekić, Ivana Tucak Junaković
This study examines the interrelations of three different aspects of the subjective age: felt, desired and expected, as well as their relations with the chronological age (CA), health, and psychological well-being variables. Four hundred and twenty-three community-dwelling Croatian adults, aged 60-95 years, participated in the study. All three subjective age measures significantly correlated with the CA. Self-rated health were better predictors of the subjective age compared to the psychological variables. Among psychological variables, successful aging was the only significant predictor of the felt and expected age, while optimism showed to be the only significant predictor of the desired age...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28718297/determination-of-aerobic-capacity-via-cycle-ergometer-exercise-testing-in-alzheimer-s-disease
#14
Ulf G Bronas, Dereck Salisbury, Kaitlin Kelly, Arthur Leon, Lisa Chow, Fang Yu
BACKGROUND: Older adults with Alzheimer's disease (AD) may be unable to perform treadmill testing due to balance issues. We investigated whether older adults with AD could successfully complete a peak cycle ergometer test. METHODS: Peak oxygen consumption (peak [Formula: see text]) assessed via a cycle ergometer test in 44 participants with AD (age 78.4 ± 6.8). Physical function was assessed via the incremental shuttle walk, 6-minute walk, and the Short Physical Performance Battery (SPPB)...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28718294/impact-of-social-integration-and-living-arrangements-on-korean-older-adults-depression-a-moderation-model
#15
Youjung Lee, Kyeonghee Jang, Naorah C Lockhart
Depression among older adults is a challenging public health concern in Korea. Using panel data from the Korea Institute for Health and Social Affairs on Korean older adults and their family caregivers, this study explores significant predictors of depression among Korean older adults as well as the moderating effect of living arrangements on the association between social integration and depression. A multivariate logistic regression analysis showed that preexisting depression was the most significant predictor of Korean older adults' current depression, followed by health status and family support...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28718176/encouraging-top-down-attention-in-visual-search-a-developmental-perspective
#16
Regan Lookadoo, Yingying Yang, Edward C Merrill
Four experiments are reported in which 60 younger children (7-8 years old), 60 older children (10-11 years old), and 60 young adults (18-25 years old) performed a conjunctive visual search task (15 per group in each experiment). The number of distractors of each feature type was unbalanced across displays to evaluate participants' ability to restrict search to the smaller subset of features. The use of top-down attention processes to restrict search was encouraged by providing external aids for identifying and maintaining attention on the smaller set...
July 17, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28718008/the-effect-of-vitamin%C3%A2-d-and-calcium-supplementation-on-falls-in-older-adults-a%C3%A2-systematic-review-and-meta-analysis
#17
Haiting Wu, Qingjiang Pang
OBJECTIVES: A number of studies have hypothesized that vitamin D is a potential factor in the prevention of falls in the elderly; however, the effect of vitamin D is still inconsistent and not quantitative. We conducted this meta-analysis to assess the effect of vitamin D on falls among elderly individuals. METHODS: The PubMed and Cochrane Library databases were searched from the earliest possible year up to December 2016. Two authors working independently reviewed the trials, and odds ratios (ORs) were calculated using a fixed-effect or random-effect model by Review Manager 5...
July 17, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28717984/falls-in-older-people-comparing-older-and-younger-fallers-in-a-developing-country
#18
R R Yogi, I Sammy, J F Paul, P Nunes, P Robertson, V Ramcharitar Maharaj
PURPOSE: While falls are common in older people, causing significant mortality and morbidity, this phenomenon has not been extensively studied in the Caribbean. This study aimed to compare falls in older and younger people in this setting. METHODS: We conducted a prospective observational study of older trauma patients in Trinidad, comparing older and younger patients sustaining falls. RESULTS: 1432 adult trauma patients were included (1141 aged 18-64 years and 291 aged 65 years and older)...
July 17, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28717929/reduction-in-targeted-potentially-inappropriate-medication-use-in-elderly-inpatients-a-pragmatic-randomized-controlled-trial
#19
Benoit Cossette, Jean-François Éthier, Thomas Joly-Mischlich, Josée Bergeron, Geneviève Ricard, Serge Brazeau, Mathieu Caron, Olivier Germain, Hélène Payette, Janusz Kaczorowski, Mitchell Levine
PURPOSE: The use of potentially inappropriate medications (PIMs) in hospitalized older adults is a complex problem, but the use of computerized alert systems (CAS) has shown some potential. The study's objective is to assess the change in PIM use with a CAS-based pharmacist-physician intervention model compared to usual clinical care. METHODS: Pragmatic single-site randomized controlled trial was conducted at a university teaching hospital. Hospitalizations identified with selected Beers or STOPP criteria were randomized to usual clinical care or to the CAS-based pharmacist-physician intervention...
July 17, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28717861/patient-perspectives-on-gene-transfer-therapy-for-sickle-cell-disease
#20
Heather Strong, Monica J Mitchell, Alana Goldstein-Leever, Lisa Shook, Punam Malik, Lori E Crosby
INTRODUCTION: Sickle cell disease (SCD) is a chronic genetic disease with high morbidity and early mortality; it affects nearly 100,000 individuals in the USA. Bone marrow transplantation, the only curative treatment, is available to less than 20% of patients because of a number of access barriers. Gene transfer therapy (GTT) has been shown to be curative in animal models and is approved for use in humans for early-phase studies at a few centers. GTT would offer a more accessible treatment option available to all patients...
July 17, 2017: Advances in Therapy
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