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https://www.readbyqxmd.com/read/29055270/executive-functioning-concern-about-falling-and-quadriceps-strength-mediate-the-relationship-between-impaired-gait-adaptability-and-fall-risk-in-older-people
#1
Maria Joana D Caetano, Stephen R Lord, Matthew A Brodie, Daniel Schoene, Paulo H S Pelicioni, Daina L Sturnieks, Jasmine C Menant
BACKGROUND: Reduced ability to adapt gait, particularly under challenging conditions, may be an important reason why older adults have an increased risk of falling. This study aimed to identify cognitive, psychological and physical mediators of the relationship between impaired gait adaptability and fall risk in older adults. METHODS: Fifty healthy older adults (mean±SD: 74±7years) were categorised as high or low fall risk, based on past falls and their performance in the Physiological Profile Assessment...
October 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29055090/performance-of-nontraditional-hyperglycemia-biomarkers-by-chronic-kidney-disease-status-in-older-adults-with-diabetes-results-from-the-atherosclerosis-risk-in-communities-study
#2
Molly Jung, Bethany Warren, Morgan Grams, Yuenting Diana Kwong, Tariq Shafi, Josef Coresh, Casey M Rebholz, Elizabeth Selvin
BACKGROUND: In persons with chronic kidney disease (CKD), hemoglobin A1c (HbA1c) may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. We investigated associations of HbA1c, glycated albumin, and fructosamine with fasting glucose by CKD categories. METHODS: Cross-sectional analysis of 1,665 Atherosclerosis Risk in Communities Study participants with diagnosed diabetes aged 65 years or older...
October 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29055029/cancer-incidence-in-adults-living-in-the-vicinity-of-nuclear-power-plants-in-france-based-on-data-from-the-french-network-of-cancer-registries
#3
Alice Desbiolles, Candice Roudier, Sarah Goria, Morgane Stempfelet, Cécile Kairo, Cécile Quintin, Marie-Laure Bidondo, Alain Monnereau, Blandine Vacquier
Nuclear power plants (NPPs) release toxic emissions into the environment that may affect neighboring populations. This ecologic study was designed to investigate the possibility of an excess incidence of cancer in the vicinity of French NPPs by examining the incidence by municipality of 12 types of cancer in the population aged 15 years and older during the 1995-2011 period. Population exposure to pollution was estimated on the basis of distance from towns of residence to the NPP. Using regression models, we assessed the risk of cancer in a 20-kilometer zone around NPPs and observed an excess incidence of bladder cancer (Relative Risk (RR), 95% Credibility Interval (95% CI)) in men and women (RRmen = 1...
October 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29054589/baseline-asthma-burden-comorbidities-and-biomarkers-in-omalizumab-treated-patients-in-prospero
#4
Bradley E Chipps, Robert S Zeiger, Allan T Luskin, William W Busse, Benjamin L Trzaskoma, Evgeniya N Antonova, Hooman Pazwash, Susan L Limb, Paul G Solari, Noelle M Griffin, Thomas B Casale
BACKGROUND: Patients included in clinical trials do not necessarily reflect the real-world population. OBJECTIVE: To understand the characteristics, including disease and comorbidity burden, of patients with asthma receiving omalizumab in a real-world setting. METHODS: The Prospective Observational Study to Evaluate Predictors of Clinical Effectiveness in Response to Omalizumab (PROSPERO) was a US-based, multicenter, single-arm, and prospective study...
October 17, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29054483/risk-and-associates-of-incident-hip-fracture-in-type-1-diabetes-the-fremantle-diabetes-study
#5
Emma J Hamilton, Wendy A Davis, David G Bruce, Timothy M E Davis
AIMS: To determine the relative risk of incident hip fracture in patients with type 1 diabetes and matched controls, to examine baseline associates of incident hip fracture in the patients with type 1 diabetes, and to compare hip fracture rates in age- and sex- matched patients with type 1 versus type 2 diabetes. METHODS: Longitudinal observational study of 121 adults with type 1 diabetes (mean±SD age 43.0±15.5 years, 59.5% male) and 484 age- and sex-matched adults without diabetes...
October 17, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29054389/optimizing-surgical-quality-datasets-to-care-for-older-adults-lessons-from-the-american-college-of-surgeons-nsqip-geriatric-surgery-pilot
#6
Julia R Berian, Lynn Zhou, Melissa A Hornor, Marcia M Russell, Mark E Cohen, Emily Finlayson, Clifford Y Ko, Thomas N Robinson, Ronnie A Rosenthal
BACKGROUND: Surgical quality datasets can be better tailored toward older adults. The American College of Surgeons (ACS) NSQIP Geriatric Surgery Pilot collected risk factors and outcomes in 4 geriatric-specific domains: cognition, decision-making, function, and mobility. This study evaluated the contributions of geriatric-specific factors to risk adjustment in modeling 30-day outcomes and geriatric-specific outcomes (postoperative delirium, new mobility aid use, functional decline, and pressure ulcers)...
September 28, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29054298/antimicrobial-resistance-in-community-acquired-urinary-tract-infections-in-paris-in-2015
#7
D Chervet, O Lortholary, J-R Zahar, A Dufougeray, B Pilmis, H Partouche
BACKGROUND: Urinary tract infection (UTI) is one of the most frequent community-acquired infection. Escherichia coli resistance has been on the rise since 2000s. METHODS: We conducted a prospective multicenter cohort study including adults who had a positive urine cytobacteriological examination (UCBE) performed in our Parisian suburb laboratory platform from October 2014 to March 2015. RESULTS: A total of 1223 patients were included: 995 (81...
October 17, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29054264/using-artificial-neural-networks-to-select-the-parameters-for-the-prognostic-of-mild-cognitive-impairment-and-dementia-in-elderly-individuals
#8
REVIEW
A J C C Lins, M T C Muniz, A N M Garcia, A V Gomes, R M Cabral, C J A Bastos-Filho
BACKGROUND AND OBJECTIVES: A huge number of solutions based on computational systems have been recently developed for the classification of cognitive abnormalities in older people, so that individuals at high risk of developing neurodegenerative diseases, such as Cognitive Impairment and Alzheimer?s disease, can be identified before the manifestation of the diseases. Several factors are related to these pathologies, making the diagnostic process a hard problem to solve. This paper proposes a computational model based on the artificial neural network to classify data patterns of older adults...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29054110/mortality-burden-from-seasonal-influenza-and-2009-h1n1-pandemic-influenza-in-beijing-china-2007-2013
#9
REVIEW
Shuangsheng Wu, Zaihua Wei, Carolyn M Greene, Peng Yang, Jianting Su, Ying Song, A Danielle Iuliano, Quanyi Wang
BACKGROUND: Data about influenza mortality burden in northern China are limited. This study estimated mortality burden in Beijing associated with seasonal influenza from 2007-2013 and the 2009 H1N1 pandemic. METHODS: We estimated influenza-associated excess mortality by fitting a negative binomial model using weekly mortality data as the outcome of interest with the percent of influenza positive samples by type/subtype as predictor variables. RESULTS: From 2007 to 2013, an average of 2,375 (CI 1,002-8,688) deaths was attributed to influenza per season, accounting for 3% of all deaths...
October 20, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29053861/physical-function-following-a-long-term-lifestyle-intervention-among-middle-aged-and-older-adults-with-type-2-diabetes-the-look-ahead-study
#10
Denise K Houston, Rebecca H Neiberg, Michael E Miller, James O Hill, John M Jakicic, Karen C Johnson, Edward W Gregg, Van S Hubbard, Xavier Pi-Sunyer, W Jack Rejeski, Rena R Wing, John P Bantle, Elizabeth Beale, Robert I Berkowitz, Maria Cassidy-Begay, Jeanne M Clark, Mace Coday, Linda M Delahanty, Gareth Dutton, Caitlin Egan, John P Foreyt, Frank L Greenway, Helen P Hazuda, Andrea Hergenroeder, Edward S Horton, Robert W Jeffery, Steven E Kahn, Anne Kure, William C Knowler, Cora E Lewis, Corby K Martin, Sara Michaels, Maria G Montez, David M Nathan, Jennifer Patricio, Anne Peters, Henry Pownall, Judith Regensteiner, Helmut Steinburg, Thomas A Wadden, Karen White, Susan Z Yanovski, Ping Zhang, Stephen B Kritchevsky
Background: Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention on physical function were assessed using a randomized post-test design in the Look AHEAD trial. Methods: Overweight and obese (BMI ≥25 kg/m 2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an intensive lifestyle intervention (ILI) designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPBexp), and grip strength approximately 11 years post-randomization and 1...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29053806/independent-association-of-plasma-hydroxysphingomyelins-with-physical-function-in-the-atherosclerosis-risk-in-communities-aric-study
#11
Danni Li, Jeffrey R Misialek, Fangying Huang, B Gwen Windham, Fang Yu, Alvaro Alonso
Background: Plasma metabolites such as phosphatidylcholines (PCs) and sphingomyelins (SMs) are associated with in age-related cognitive decline. However, their relations to age-related physical function decline remain largely unknown. Methods: We examined the cross-sectional relations of 12 plasma metabolites (including 4 PCs and 4 SMs) with physical function in 383 older adults in the Atherosclerosis Risk in Communities study at the fifth exam (2011-13, mean age [standard deviation (SD)]: 78...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29053783/systematic-assessment-of-multiple-routine-and-near-real-time-indicators-to-classify-the-severity-of-influenza-seasons-and-pandemics-in-the-united-states-2003-04-through-2015-2016
#12
Matthew Biggerstaff, Krista Kniss, Daniel B Jernigan, Lynnette Brammer, Joseph Bresee, Shikha Garg, Erin Burns, Carrie Reed
Assessments of influenza season severity can guide public health action. We used the Moving Epidemic Method to develop intensity thresholds (IT) for 3 US surveillance indicators from the 2003-04-2014-15 influenza season (excluding the 2009 pandemic): 1) outpatient visits for influenza-like illness, 2) influenza-related hospitalizations, and 3) influenza- and pneumonia-related deaths. ITs were developed for the overall population and children, adults, and older adults separately and were the upper limit of the 50% (IT50), 90% (IT90), and 98% (IT98) one-sided CIs of the geometric mean of each season's 3 highest values...
October 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29053774/plasma-klotho-and-frailty-in-older-adults-findings-from-the-inchianti-study
#13
Michelle Shardell, Richard D Semba, Rita R Kalyani, Stefania Bandinelli, Aric A Prather, Chee W Chia, Luigi Ferrucci
Background: The hormone klotho, encoded by the gene klotho, is primarily expressed in the kidney and choroid plexus of the brain. Higher klotho concentrations have been linked to better physical performance; however, it is unknown whether klotho relates to frailty status in older adults. Methods: Plasma klotho was measured in 774 participants aged ≥ 65 years enrolled in InCHIANTI, a prospective cohort study comprising Italian adults. Frailty status was assessed at three and six years after enrollment...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29053746/external-auditory-exostoses-and-hearing-loss-in-the-shanidar-1-neandertal
#14
Erik Trinkaus, Sébastien Villotte
The Late Pleistocene Shanidar 1 older adult male Neandertal is known for the crushing fracture of his left orbit with a probable reduction in vision, the loss of his right forearm and hand, and evidence of an abnormal gait, as well as probable diffuse idiopathic skeletal hyperostosis. He also exhibits advanced external auditory exostoses in his left auditory meatus and larger ones with complete bridging across the porus in the right meatus (both Grade 3). These growths indicate at least unilateral conductive hearing (CHL) loss, a serious sensory deprivation for a Pleistocene hunter-gatherer...
2017: PloS One
https://www.readbyqxmd.com/read/29053575/the-impact-of-a-weight-loss-intervention-on-diet-quality-and-eating-behaviours-in-people-with-obesity-and-copd
#15
Rebecca F McLoughlin, Vanessa M McDonald, Peter G Gibson, Hayley A Scott, Michael J Hensley, Lesley MacDonald-Wicks, Lisa G Wood
There is a paucity of evidence to guide clinicians about appropriate management strategies for people with obesity and Chronic Obstructive Pulmonary Disease (COPD). We have recently published results from the first weight loss intervention in adults (>18 years) with obesity (body mass index; BMI ≥ 30 kg/m²) and COPD, using a low-calorie diet coupled with a partial meal replacement plan and resistance exercise training, which resulted in a 6.4% reduction in weight while maintaining skeletal muscle mass and improving health status...
October 20, 2017: Nutrients
https://www.readbyqxmd.com/read/29053238/older-adults-affected-by-gene-mutations-when-taking-multiple-medications
#16
(no author information available yet)
No abstract text is available yet for this article.
February 23, 2017: Journal of the California Dental Association
https://www.readbyqxmd.com/read/29052953/cross-cultural-adaptation-and-validation-of-the-comprehensive-frailty-assessment-instrument-in-chinese-community-dwelling-older-adults
#17
Xiaoxia Qiao, Cuili Wang, Xiaoyu Tian, Lijuan Dong, Na Liu, Yaru Jin, Huaxin Si
AIM: To cross-culturally adapt and validate the Comprehensive Frailty Assessment Instrument (CFAI) among Chinese community-dwelling older adults. METHODS: The Chinese CFAI was developed through forward-backward translations. An urban sample of 1235 community-dwelling older adults received face-to-face interviews to examine the validity (construct validity and criterion validity) and reliability (internal consistency and test-retest reliability). RESULTS: The Chinese CFAI achieved semantic and idiomatic equivalence, and showed acceptable reliability and an expected factor structure, except for the social support domain...
October 20, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29052947/exploring-opportunities-to-support-mental-health-care-using-social-media-a-survey-of-social-media-users-with-mental-illness
#18
John A Naslund, Kelly A Aschbrenner, Gregory J McHugo, Jürgen Unützer, Lisa A Marsch, Stephen J Bartels
AIM: Social media holds promise for expanding the reach of mental health services, especially for young people who frequently use these popular platforms. We surveyed social media users who self-identified as having a mental illness to learn about their use of social media for mental health and to identify opportunities to augment existing mental health services. METHODS: We asked 240 Twitter users who self-identified in their profile as having a mental illness to participate in an online survey...
October 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29052935/relationship-between-chronic-kidney-disease-without-diabetes-mellitus-and-components-of-frailty-in-community-dwelling-japanese-older-adults
#19
Sungchul Lee, Sangyoon Lee, Seongryu Bae, Kazuhiro Harada, Songee Jung, Masakazu Imaoka, Hyuma Makizako, Takehiko Doi, Hiroyuki Shimada
AIM: To evaluate the relationship between kidney function without diabetes and components of the frailty phenotype in community-dwelling Japanese older adults. METHODS: Participants were 8343 residents who completed baseline assessments, classified into four categories according to eGFR. Frailty status was defined using five criteria: (i) slow gait speed; (ii) muscle weakness; (iii) low physical activity; (iv) exhaustion; and (v) unintentional weight loss. RESULTS: After multivariate adjustment, participants with the lowest kidney function were at higher risk of frailty (OR 1...
October 20, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29052928/relationship-between-physical-activity-levels-and-depressive-symptoms-in-community-dwelling-older-japanese-adults
#20
Songee Jung, Sangyoon Lee, Sungchul Lee, Seongryu Bae, Masakazu Imaoka, Kazuhiro Harada, Hiroyuki Shimada
AIM: The aim of the present study was to investigate the relationship between physical activity (PA) and depressive symptoms in community-dwelling older Japanese adults. METHODS: A cross-sectional study design was used to obtain data from 3191 community-dwelling older Japanese adults aged 70-95 years. Depressive symptoms were assessed using self-reported scores on the Geriatric Depression Scale-15. PA was objectively measured using an accelerometer worn for a maximum of 40 days, and average daily durations of light-intensity PA (LPA), moderate-to-vigorous intensity PA (MVPA) and step count were calculated...
October 20, 2017: Geriatrics & Gerontology International
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