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BACKGROUND: There are a few case reports regarding transcatheter aortic valve implantation (TAVI) for deteriorated surgical homograft. CASE SUMMARY: We present a case of severe structural valve deterioration (SVD) of homograft surgical aortic valve presenting severe aortic regurgitation in an 84-year-old man with decompensated heart failure. We performed TAVI in homograft valve using 23 mm SAPIEN3 Ultra RESILIA. The resulting grade of paravalvular regurgitation was trace, the post-operative effective orifice area (EOA) was 1...

BACKGROUND: Low-dose computed tomography (LDCT) has been shown useful in early lung cancer detection. This study aimed to develop a novel deep learning model for detecting pulmonary nodules on chest LDCT images. METHODS: In this secondary analysis, three lung nodule datasets, including Lung Nodule Analysis 2016 (LUNA16), Lung Nodule Received Operation (LNOP), and Lung Nodule in Health Examination (LNHE), were used to train and test deep learning models. The 3D region proposal network (RPN) was modified via a series of pruning experiments for better predictive performance...

Рurроse - to evaluate the influence of aging, beverages, and mouthwash solutions on the microstructural and color stability of three CAD/CAM ceramic materials. In total, 87 specimens (7×5×1.5 mm) were prepared from 3 CAD/CAM ceramic groups, Lithium Disilicate glass ceramic (IPS e.max CAD), Extra translucent zirconia (VITA YZ), and Resin Nanoceramic (Cerasmart 270). All the materials were A2 or equivalent shades. After hydrothermal aging in distilled water at 5 C to 55 C for (10.000 cycles)...

This paper presents a new approach for finding exact solutions to certain classes of nonlinear partial differential equations (NLPDEs) by combining the variation of parameters method with classical techniques such as the method of characteristics. Our primary focus is on NLPDEs of the form <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:mrow><mml:msub><mml:mi>u</mml:mi> <mml:mrow><mml:mi>tt</mml:mi></mml:mrow> </mml:msub> <mml:mo>+</mml:mo> <mml:mi>a</mml:mi> <mml:mrow><mml:mo>(</mml:mo> <mml:mi>x</mml:mi> <mml:mo>,</mml:mo> <mml:mi>t</mml:mi> <mml:mo>)</mml:mo></mml:mrow> <mml:msub><mml:mi>u</mml:mi> <mml:mrow><mml:mi>xt</mml:mi></mml:mrow> </mml:msub> <mml:mo>+</mml:mo> <mml:mi>b</mml:mi> <mml:mrow><mml:mo>(</mml:mo> <mml:mi>t</mml:mi> <mml:mo>)</mml:mo></mml:mrow> <mml:msub><mml:mi>u</mml:mi> <mml:mi>t</mml:mi></mml:msub> <mml:mo>=</mml:mo> <mml:mi>α</mml:mi> <mml:mrow><mml:mo>(</mml:mo> <mml:mi>x</mml:mi> <mml:mo>,</mml:mo> <mml:mi>t</mml:mi> <mml:mo>)</mml:mo></mml:mrow> <mml:mo>+</mml:mo> <mml:mi>G</mml:mi> <mml:mrow><mml:mo>(</mml:mo> <mml:mi>u</mml:mi> <mml:mo>)</mml:mo></mml:mrow> <mml:mrow><mml:mo>(</mml:mo> <mml:msub><mml:mi>u</mml:mi> <mml:mi>t</mml:mi></mml:msub> <mml:mo>+</mml:mo> <mml:mi>a</mml:mi> <mml:mrow><mml:mo>(</mml:mo> <mml:mi>x</mml:mi> <mml:mo>,</mml:mo> <mml:mi>t</mml:mi> <mml:mo>)</mml:mo></mml:mrow> <mml:msub><mml:mi>u</mml:mi> <mml:mi>x</mml:mi></mml:msub> <mml:mo>)</mml:mo></mml:mrow> <mml:msup><mml:mi>e</mml:mi> <mml:mrow><mml:mo>-</mml:mo> <mml:mo>∫</mml:mo> <mml:mi>b</mml:mi> <mml:mo>(</mml:mo> <mml:mi>t</mml:mi> <mml:mo>)</mml:mo> <mml:mi>d</mml:mi> <mml:mi>t</mml:mi></mml:mrow> </mml:msup> </mml:mrow> </mml:math> and <mml:math xmlns:mml="https://www...

BACKGROUND: Universal adhesive systems used for restorative clinical procedures are like orthodontics and may be a viable option. This study evaluated the effectiveness of universal adhesive systems in enhancing the durability of the shear bond strength (SBS) and adhesive remnant index (ARI) of orthodontic brackets to enamel. MATERIAL AND METHODS: 100 bovine incisors were divided into five groups (n=20), according to the applied adhesive systems: Primer Transbond XT; Ambar; Ambar Universal; Single Bond Universal; Adper Single Bond 2...

BACKGROUND: Low physical activity (PA) measured from accelerometers and low heart rate variability (HRV) measured from short-term ECG recordings are associated with worse cognitive function. Wearable long-term ECG monitors are now widely used. These monitors can provide long-term HRV data and, if embedded with an accelerometer, they can also provide PA data. Whether PA or HRV measured from long-term ECG monitors is associated with cognitive function among older adults is unknown. METHODS: Free-living PA and HRV were measured simultaneously over 14-days using the Zio ® XT Patch among 1590 participants in the Atherosclerosis Risk in Communities Study [aged 72-94 years, 58% female, 32% Black]...

OBJECTIVES: Evaluate the ability of strontium fluoride on bond strength and enamel integrity after incorporation within orthodontic adhesive system as a delivery vehicle. METHODS: Experimental orthodontic adhesive system Transbond™ XT were modified with 1% Sr2+ , 0.5% SrF2 , 1% strontium, 0.5% Sr2+ , 1% F- , 0.5% F- , and no additions were control. Mixing of formulation was monitored using Fourier transform infrared spectroscopy. Small-molecule drug-discovery suite was used to gain insights into Sr2+ , F- , and SrF2 binding...

Experimental autoimmune neuritis is a common animal model for acute human immune-mediated polyneuropathies. Although already established in 1955, a number of pathophysiological mechanisms remain unknown. In this study, we extensively characterize experimental autoimmune neuritis progression in Lewis rats, including new insights into the integrity of small nerve fibres, neuropathic pain and macrophage activation. Acute experimental autoimmune neuritis was induced with P253-78 peptide and consequently investigated using the gait analysis system CatWalk XT, electrophysiological and histopathological analyses, quantitative polymerase chain reaction (PCR), dorsal root ganglia outgrowth studies, as well as the von Frey hair and Hargreaves tests...

Lactones are cyclic esters of hydroxy carboxylic acids, present in several fruits and animals consumed by humans. There is evidence that some lactones modify insect behavior. The aim of the present study was to evaluate the repellent effect of four lactones (γ- and δ-nonalactone, and γ- and δ-dodecalactone) in first instar nymphs of the German cockroach, Blattella germanica (Linnaeus). To assess repellency, a nymph was placed on a circle of filter paper, half of which had been treated with lactone dissolved in acetone and the other half with acetone alone...

This research explores how biracial facial cues affect racial perception and social judgment. We tested a coalition-signaling hypothesis of biracial cues in two studies conducted in the United States ( n  = 227) and China ( n  = 116). From the perspective of intergroup and interpersonal relations theories in social psychology, biracial features would likely be perceived as cues of threat or resource competition. In contrast, we propose an evolutionary hypothesis that biracial facial cues reveal the ancestral history of intergroup alliances between members of two races or ethnic groups...

BACKGROUND: Reverse Shoulder Arthroplasties (RSA) have become a primary choice for improving shoulder function and pain. However, the biomechanical failure mechanism of the humeral component is still unclear. The present study reports a novel protocol for microstructural imaging of the entire humerus implant under load before and after fracture. METHODS: A humerus specimen was obtained from a 75-year-old male donor. An expert surgeon implanted the specimen with a commonly used RSA implant (Aequalis reversed II, Stryker Orthopaedics, USA) and surgical procedure...

The aim of this study was to evaluate the effect of cetylpyridinium chloride (CPC) addition on the antibacterial and surface hardness characteristics of two commercial resin-based dental composites (RBDCs). A total of two hundred and seventy ( n = 270) specimens from Filtek Z250 Universal and Filtek Z350 XT flowable RBDCs were fabricated with the addition of CPC at 2 %wt and 4 %wt concentrations to assess their antibacterial activity using the agar diffusion test and direct contact inhibition test, and their surface hardness using the Vickers microhardness test after 1 day, 30 days, and 90 days of aging...

AIM: To acquire a thorough comprehension of the photoactivated Cur-doped ZnONPs at different concentrations 0%, 2.5%, and 5% on the physical qualities, antibacterial efficacy, degree of conversion, and μshear bond strength between orthodontic brackets and the enamel surface. MATERIAL AND METHODS: An extensive investigation was carried out utilizing a range of analytical methods, scanning electron microscopy (SEM) combined with energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared (FTIR) spectroscopy, micro tensile bond strength (μTBS) testing, and evaluation of antibacterial effectiveness...

BACKGROUND: Escherichia coli, a ubiquitous inhabitant of the gut microbiota, has been recognized as an indicator of fecal contamination and a potential reservoir for antibiotic resistance genes. Its prevalence in drinking water sources raises concerns about the potential dissemination of antibiotic resistance within aquatic ecosystems and the subsequent impact on public health. The ability of E. coli to acquire and transfer resistance genes, coupled with the constant exposure to low levels of antibiotics in the environment, underscores the need for comprehensive surveillance and rigorous antimicrobial stewardship strategies to safeguard the quality and safety of drinking water supplies, ultimately mitigating the escalation of antibiotic resistance and its implications for human well-being...

The electrochemical conversion of nitrogen to ammonia provides an encouraging method to substitute the traditional Haber-Bosch process, owing to its high efficiency and mild reaction conditions. The search for high-performance catalysts and comprehension of catalytic mechanisms remains significant challenges. Herein, we conduct a systematic theoretical calculation of the NRR performance and mechanism of 24 Ti2 XT2 (X = B, C, N; T = F, Cl, Br, I, O, S, Se, Te) MXenes with a T-vacancy to explore the influence of surface functional terminations and non-metallic center elements...

PURPOSE: Notable effectiveness of trastuzumab deruxtecan (T-DXd) in patients with HER2-low advanced breast cancer (BC) has focused pathologists' attention. We studied the incidence and clinicopathologic characteristics of HER2-low BC, and the effects of immunohistochemistry (IHC) associated factors on HER2 IHC results. MATERIALS AND METHODS: The Breast Pathology Study Group of the Korean Society of Pathologists conducted a nationwide study using real-world data on HER2 status generated between January 2022 and December 2022...

BACKGROUND AND OBJECTIVE: Previous literature has reported that red cell distribution width (RDW) correlated with Alzheimer's disease (AD), but the correlation with mild cognitive impairment (MCI) was not clear. This study aimed to investigate MCI in the residents aged ≥65 living in the suburban of Shanghai, China. MATERIALS AND METHODS: A total of 550 participants were recruited as MCI (MCI group, 226) and normal (NC group, 284) groups and received blood examination voluntarily...

BACKGROUND: Although end stage renal disease patients who undergo hemodialysis frequently experience dialysis-associated thrombotic complications, there remains a paucity of literature comparing the efficacy of different endovascular salvage techniques for grafts and fistulas. This study aims to compare primary patency in dialysis access following salvage mechanical thrombolysis/thrombectomy with a rotational thrombolysis device versus balloon maceration. METHODS: Using a database of patient records at a tertiary medical center, all patients who underwent rotational thrombectomy with the Cleaner XT™ Rotational Thrombectomy System for endovascular salvage of arteriovenous fistula or arteriovenous graft from August 2016 to July 2022 were included in the population...

OBJECTIVES: To assess the effects of aging and bleaching procedures on the color stability and surface roughness of a new single-shade composite resin versus multi-shade composite resins. METHODS: A single-shade composite resin (Charisma Diamond One, CDO) and 3 multi-shade composite resins (Tetric N-Ceram, Filtek Z350 XT, Clearfil Majesty Posterior) were tested. Thirty specimens of each material were subjected to one of the aging procedures respectively: immersion in distilled water (12 days/37°C), immersion in coffee (12 days/37°C), and or water thermocycling (10000 cycles/5-55°C)...

UNLABELLED: Chemistry in eukaryotic intercellular spaces is shaped by both hosts and symbiotic microorganisms such as bacteria. Pathogenic microorganisms like barley-associated Xanthomonas translucens (Xt) swiftly overtake the inner leaf tissue becoming the dominant microbial community member during disease development. The dynamic metabolic changes due to Xt pathogenesis in the mesophyll spaces remain unknown. Genomic group I of Xt consists of two barley-infecting lineages: pathovar translucens (Xtt) and pathovar undulosa (Xtu)...