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Agnieszka Wacławczyk, Lidia Postek-Stefańska, Daria Pietraszewska, Ewa Birkner, Jolanta Zalejska-Fiolka, Iwona Wysoczańska-Jankowicz
BACKGROUND: More than 35 substances released from composite fillings have been identified. Among these, basic monomers and the so-called co-monomers are most often reported. The substances released from polymer-based materials demonstrate allergenic, cytotoxic, genotoxic, mutagenic, embryotoxic, teratogenic, and estrogenic properties. OBJECTIVES: The aim of this study was to measure the amounts of triethylene glycol dimethacrylate (TEGDMA) and urethane dimethacrylate (UDMA) monomers released from composite dental fillings to citrate-phosphate buffer with the pH of 4, 6, 8 after 24 h and 6 months from the polymerization...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Marta Rasal Carnicer, Laura Juguera Rodríguez, Nuria Vela de Oro, Ana Belén García Pérez, Nuria Pérez Alonso, Manuel Pardo Ríos
OBJECTIVES: The main purpose of this study in healthy volunteers was to compare the lung function effects of 2 extrication devices that use spinal vests: the Kendrick Extrication Device (KED) and the Ferno KED-XT board. MATERIAL AND METHODS: Randomized crossover trial in 50 healthy adult volunteers. The subjects were placed in the KED and KED-XT devices for 5 minutes each and rested for 10 minutes between devices. Assignment to the first device was randomized. Each subject underwent spirometry at baseline and after placement of each device...
2018: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
Timothy Kwang Yong Tay, Aye Aye Thike, Nirmala Pathmanathan, Ana Richelia Jara-Lazaro, Jabed Iqbal, Adeline Shi Hui Sng, Heng Seow Ye, Jeffrey Chun Tatt Lim, Valerie Cui Yun Koh, Jane Sie Yong Tan, Joe Poh Sheng Yeong, Zi Long Chow, Hui Hua Li, Chee Leong Cheng, Puay Hoon Tan
Background: Ki67 positivity in invasive breast cancers has an inverse correlation with survival outcomes and serves as an immunohistochemical surrogate for molecular subtyping of breast cancer, particularly ER positive breast cancer. The optimal threshold of Ki67 in both settings, however, remains elusive. We use computer assisted image analysis (CAIA) to determine the optimal threshold for Ki67 in predicting survival outcomes and differentiating luminal B from luminal A breast cancers...
February 20, 2018: Oncotarget
Yutaka Tanaka, Shigeru Saito, Saeko Sasuga, Azuma Takahashi, Yusuke Aoyama, Kazuto Obama, Mitsuo Umezu, Kiyotaka Iwasaki
BACKGROUND: Quantitative assessment of post-transcatheter aortic valve replacement (TAVR) aortic regurgitation (AR) remains challenging. We developed patient-specific anatomical models with pulsatile flow circuit and investigated factors associated with AR after TAVR. METHODS: Based on pre-procedural computed tomography (CT) data of the six patients who underwent transfemoral TAVR using a 23-mm SAPIEN XT, anatomically and mechanically equivalent aortic valve models were developed...
May 1, 2018: International Journal of Cardiology
Thalía Domínguez Bucio, Ali Z Khokhar, Goran Z Mashanovich, Frederic Y Gardes
We report the design and fabrication of a compact angled multimode interferometer (AMMI) on a 600 nm thick N-rich silicon nitride platform (n=1.92) optimized to match the International Telecommunication Union coarse wavelength division (de)multiplexing standard in the O telecommunication band. The demonstrated device exhibited a good spectral response with Δλ=20  nm, BW3 dB ∼11  nm, IL<1.5  dB, and XT∼20  dB. Additionally, it showed a high tolerance to dimensional errors <120  pm/nm and low sensitivity to temperature variations <20  pm/°C, respectively...
March 15, 2018: Optics Letters
Yan Liu, Ling Zhang, Li-Na Niu, Tao Yu, Hockin H K Xu, Michael D Weir, Thomas W Oates, Franklin R Tay, Ji-Hua Chen
OBJECTIVES: To evaluate the bonding performance, antibacterial activity, and remineralization effect on enamel of the orthodontic adhesive containing MAE-DB and NACP. METHODS: Eighty non-carious human premolars were divided into 3 groups: Transbond XT (TB), PEHB + 5% MAE-DB (PD), and PEHB + 40% NACP + 5% MAE-DB (PND). Premolars were bonded with orthodontic brackets, the first subgroup (n = 10) and the second subgroup (n = 10) were subjected to shear bond strength testing after immersed in water for 1 day and in demineralization solution for 28 days respectively and then tested surface roughness, while the third subgroup (n = 6) was used for microhardness evaluation after aged in demineralization solution for 28 days...
March 10, 2018: Journal of Dentistry
M Demirci, S Tuncer, H S Sancakli, N Tekçe, C Baydemir
The purpose of this study was to evaluate a nanofilled and a nanohybrid composite, in combination with manufacturer-recommended etch-and-rinse adhesives, in class IV cavities. Thirty-four patients aged 14-46 years (mean age, 27.1 years) comprised the study group. Twenty-six patients received two class IV restorations and eight patients received four class IV restorations. For each patient, half the number of restorations were performed using a nanohybrid composite (Ceram X duo) and the remaining half used a nanofilled resin composite (Filtek Supreme XT), with two- (XP Bond) and three-step (Scotchbond Multipurpose) etch-and-rinse adhesives, respectively...
March 13, 2018: Operative Dentistry
Lin Gan, Li Shen, Ming Tang, Chen Xing, Yanpeng Li, Changjian Ke, Weijun Tong, Borui Li, Songnian Fu, Deming Liu
We investigate the evolution of the decorrelation bandwidth of intercore crosstalk (IC-XT) based on the modified mode-coupled equations (MCEs) in homogeneous weakly coupled multicore fibers (WC-MCFs). The modified MCEs are numerically solved by combining the fourth order Runge-Kutta method with the compound Simpson integral method. It can be theoretically and numerically observed that the decorrelation bandwidth of IC-XT decreases with transmission distance by fractional linear function. The evolution rule of IC-XT's decorrelation bandwidth is further confirmed by experiments, which can be used as an evaluation criterion for the channel model...
March 5, 2018: Optics Express
Renata Nunes Cabral, Jorge Faber, Simone Auxiliadora Morais Otero, Leandro Augusto Hilgert, Soraya Coelho Leal
OBJECTIVES: The aim of this study was to compare the caries-preventive effect and the retention rates of sealants prepared with a new modified and a high-viscosity glass-ionomer cement (GIC) in recently erupted first permanent molars.  MATERIALS AND METHODS: Fifty-six children (224 teeth) were included in a split-mouth randomised clinical trial. All children had their four first permanent molars sealed with either Clinpro XT Varnish (CXT) or Fuji IX GP FAST (FJ). FJ sealants were placed according to the ART protocol...
March 9, 2018: Clinical Oral Investigations
Eoin J White, Muireann McMahon, Michael T Walsh, J Calvin Coffey, Leonard W O'Sullivan
The aim of this study was to quantify laparoscopic instrument use and actions of both limbs during a sample of common colorectal surgical procedures. A method was devised using Observer XT software to code video recordings. Anonymised HD video recordings of nine laparoscopic colorectal procedures performed by a single surgeon were analysed. We determined the percentage and frequency of instrument use and limb actions throughout the total laparoscopic surgical duration, as well as the duration of instrument inactivity...
March 5, 2018: Applied Ergonomics
A E Taylor, M R Bedford, H M Miller
Non-starch polysaccharides (NSP) present in wheat and barley can act as anti-nutrients leading to an increase in digesta viscosity and a reduction in nutrient digestibility. Xylanase, an NSP-degrading enzyme, has been shown to increase nutrient digestibility in pigs. The objectives of this study were: (1) to identify the optimum inclusion level of xylanase in grower pig diets by measuring the effect of increasing enzyme levels on growth performance, the concentration of volatile fatty acids (VFA) and peptide YY concentration in portal and peripheral blood of grower pigs and (2) to increase our understanding of the interrelationships between xylanase inclusion, VFA production and peptide YY secretion...
March 6, 2018: Animal: An International Journal of Animal Bioscience
Jiang Liu, Jun-Ling Zhu, Ya-Li Zhang, Yang Bai
OBJECTIVE: To explore the expression of the family with sequence similarity 135 member B (FAM135B) and K(lysine) acetyltransferase 5 (KAT5) in esophageal squamous cell carcinoma (ESCC) in Uygur patients. METHODS: The expression of FAM135B and KAT5 in ESCC tissues and paired adjacent tissues from 40 Uygur patients were detected using Roche Benchmark XT. The correlation of FAM135B and KAT5 and their correlation with the clinicopathological characteristics of the patients were analyzed...
February 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Elizabeth S Silagi, Irving M Shapiro, Makarand V Risbud
Few human tissues have functions as closely linked to the composition of their extracellular matrices as the intervertebral disc. In fact, the hallmark of intervertebral disc degeneration, commonly accompanying low back and neck pain, is the progressive loss of extracellular matrix molecules - specifically the GAG-substituted proteoglycans. While this loss is often associated with increased extracellular catabolism via metalloproteinases and pro-inflammatory cytokines, there is strong evidence that disc degeneration is related to dysregulation of the enzymes involved in GAG biosynthesis...
March 1, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
Mohammad Hossein Toodehzaeim, Hengameh Zandi, Hamidreza Meshkani, Azadeh Hosseinzadeh Firouzabadi
Statement of the Problem: Orthodontic appliances facilitate microbial plaque accumulation and increase the chance of white spot lesions. There is a need for new plaque control methods independent of patient's cooperation. Purpose: The aim of this study was to determine the effects of incorporating copper oxide (CuO) nanoparticles on antimicrobial properties and bond strength of orthodontic adhesive. Materials and Method: CuO nanoparticles were added to the composite transbond XT at concentrations of 0...
March 2018: Journal of Dentistry
Kyungae Jo, Hyeon-Son Choi, SangDuck Jeon, Chang-Won Ahn, Hyung Joo Suh
The sleep-promoting effects of the water extract of Nelumbo nucifera seeds (NNE) were investigated in an invertebrate model. The effects of NNE on the subjective nighttime activity, sleep episodes, and sleep time were determined using Drosophila melanogaster and locomotor activity monitoring systems in basal and caffeine-induced arousal conditions. The movements of fruit flies were analyzed using the Noldus EthoVision-XT system, and the levels of neuromodulators were analyzed using HPLC. Expression of neuromodulator receptors was analyzed using real-time PCR...
2018: Biological & Pharmaceutical Bulletin
Ji-Yeon Lee, Jaechan Ahn, Sang In An, Jeong-Won Park
Objectives: The aim of this study is to compare the shear bond strengths of ceramic brackets bonded to zirconia surfaces using different zirconia primers and universal adhesive. Materials and Methods: Fifty zirconia blocks (15 × 15 × 10 mm, Zpex, Tosoh Corporation) were polished with 1,000 grit sand paper and air-abraded with 50 µm Al2 O3 for 10 seconds (40 psi). They were divided into 5 groups: control (CO), Metal/Zirconia primer (MZ, Ivoclar Vivadent), Z-PRIME Plus (ZP, Bisco), Zirconia Liner (ZL, Sun Medical), and Scotchbond Universal adhesive (SU, 3M ESPE)...
February 2018: Restorative Dentistry & Endodontics
Giorgia M Bosi, Claudio Capelli, Mun Hong Cheang, Nicola Delahunty, Michael Mullen, Andrew M Taylor, Silvia Schievano
Patient-specific computational models are an established tool to support device development and test under clinically relevant boundary conditions. Potentially, such models could be used to aid the clinical decision-making process for percutaneous valve selection; however, their adoption in clinical practice is still limited to individual cases. To be fully informative, they should include patient-specific data on both anatomy and mechanics of the implantation site. In this work, fourteen patient-specific computational models for transcatheter aortic valve replacement (TAVR) with balloon-expandable Sapien XT devices were retrospectively developed to tune the material parameters of the implantation site mechanical model for the average TAVR population...
February 20, 2018: Journal of Biomechanics
Tiago Casella, Andressa Batista Zequini de Morais, Diego Diniz de Paula Barcelos, Fernanda Modesto Tolentino, Louise Teixeira Cerdeira, Maria Fernanda Campagnari Bueno, Gabriela Rodrigues Francisco, Leonardo Neves de Andrade, Ana Lucia da Costa Darini, Doroti de Oliveira Garcia, Nilton Lincopan, Mara Corrêa Lelles Nogueira
OBJECTIVES: Klebsiella pneumoniae is considered an opportunistic pathogen and important agent of nosocomial and community infections. It presents the ability to capture and harbor several antimicrobial resistance genes, and in this context, the extensive use of carbapenems to treat serious infections was responsible for selection of several resistance genes. In this study, we report the draft genome sequence of a KPC-2-procuding K. pneumoniae strain (Kp10) simultaneously harboring the blaCTX-M-15 and blaCTX-M-59 genes, isolated from urine culture of a patient with Parkinson's disease...
February 21, 2018: Journal of Global Antimicrobial Resistance
Doreen Richardt, Sherazade Luise Haban-Rackebrandt, Sina Stock, Michael Scharfschwerdt, Hans-Hinrich Sievers
OBJECTIVES: Transcatheter aortic valve implantation is a treatment strategy for degenerated aortic valve prostheses, but there is some concern regarding valve thrombosis. The optimal anticoagulation strategy for implantation of a transcatheter aortic valve prosthesis remains unclear. METHODS: Aortic root models with the Sapien-XT and S3 prostheses (sizes 23 and 26) fixed in a Perimount Magna Ease bioprosthesis (sizes 23 and 25) were constructed. The haemodynamics of the left ventricle were imitated in a proved in vitro model...
February 15, 2018: European Journal of Cardio-thoracic Surgery
Andy C Kiser, Thomas G Caranasos, Mark D Peterson, David M Holzhey, Philipp Kiefer, L Wiley Nifong, Michael A Borger
OBJECTIVE: Recently, the PARTNER 2A trial reported results of transcatheter aortic valve replacement versus surgical aortic valve replacement in 2032 intermediate-risk patients at 2 years. Two hundred thirty-six patients (24%) required an access route other than transfemoral. Compared with transfemoral and surgical aortic valve replacement, nontransfemoral transcatheter aortic valve replacement was associated with a numerically higher rate of death and disabling stroke at 30 days. This underscores the need for a better alternative surgical approach for patients with marginal femoral access...
February 17, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
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