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https://www.readbyqxmd.com/read/29776011/predicting-nonadherence-to-adjuvant-endocrine-therapy-in-women-with-early-stage-breast-cancer
#1
Arden L Corter, Reuben Broom, David Porter, Vernon Harvey, Michael Findlay
BACKGROUND: Failing to take endocrine therapy (ET) as prescribed (nonadherence) increases risk of morbidity and mortality from breast cancer recurrence. We explored predictors of nonadherence, including demographic, clinical, treatment and personal factors, among women newly prescribed ET for early stage breast cancer. We also examined predictors of their thoughts about stopping treatment (TST). METHODS: A baseline survey prior to ET assessed demographics, illness beliefs, beliefs about medicines, fear of recurrence, symptoms and negative affect...
May 18, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29775798/to-detect-or-not-to-detect-a-replication-and-extension-of-the-three-stage-model
#2
Alexander B Swan, Dustin P Calvillo, Russell Revlin
When faced with a decision, people generally show a bias toward heuristic processing, even if it leads to the incorrect decision, such as in the base-rate neglect task. The crucial question is whether people know that they are biased. Recently, the three-stage model (Pennycook, Fugelsang, & Koehler, 2015) suggested that detecting this bias (conflict detection) is imperfect and a consistent source of bias because some people do not recognize that they are making biased decisions. In Experiment 1, participants completed a base-rate neglect task as replication of Pennycook et al...
May 15, 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29775602/shining-a-light-on-alport-syndrome
#3
Lorna J Hale, Melissa H Little
In this issue of Cell Chemical Biology, Omachi et al. (2018) present a split Nanoluciferase system to identify successful protein trimerization in Alport syndrome. This elegant proof of concept suggests opportunities for drug screening for Alport syndrome and may be transferable to the study of other diseases affecting protein-protein interactions.
May 17, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29775601/cells-stiffen-for-cytokines
#4
Richard Newton, Daniel J Müller
In this issue of Cell Chemical Biology, Knoops et al. (2018) use a novel approach in immunology: combining confocal microscopy and atomic force microscopy to unravel the specific interaction of oxidized peroxiredoxin-5 with Toll-like receptor 4 that leads to the release of interleukin-1β and the stiffening of mammalian cells.
May 17, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29775590/social-isolation-co-opts-fear-and-aggression-circuits
#5
Jose Rodriguez-Romaguera, Garret D Stuber
Social isolation is a stressful condition that often leads to maladaptive behaviors. In this issue of Cell, Zelikowsky et al. find that chronic social isolation stress triggers an increase in neuronal tachykinin signaling across distinct brain regions that mediate fear and aggression, elucidating the neural basis of these maladaptive responses.
May 17, 2018: Cell
https://www.readbyqxmd.com/read/29775588/neurons-are-the-inflammatory-problem
#6
Kevin J Tracey
The discovery that reflex neuronal circuits control immunity provided a new mechanistic understanding of infection and injury. Pinho-Ribeiro et al. (2018) report that lethal tissue destruction from streptococcal necrotizing fasciitis ("flesh-eating disease") occurs because sensory neurons reflexively inhibit frontline immune responses.
May 17, 2018: Cell
https://www.readbyqxmd.com/read/29775576/the-quest-for-stability-during-times-of-change
#7
Quincey Justman
Experimental tools that are designed to perturb biological functions are often used to understand how cells change over time. However, in two recent papers, Segall-Shapiro et al. (2018; in Nature Biotechnology) and Rullan et al. (2018; in this issue of Molecular Cell) present tools engineered to keep cells the same. Both tools achieve perfect adaptation, that is, the ability to hold a value, in this case gene expression, constant over time despite disruptions and disturbances. Together, these papers highlight how influential dynamics can be when shaping biological functions, even when the goal is to stay constant...
May 17, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29775575/at-long-last-a-c-terminal-bookend-for-the-ubiquitin-code
#8
Andrew Chatr-Aryamontri, Almer van der Sloot, Mike Tyers
The ubiquitin-proteasome system controls the stability of myriad protein substrates via short sequence motifs called degrons. Studies by Koren et al. (2018) and Lin et al. (2018) have uncovered a broad new class of degrons located at the extreme C terminus of substrates.
May 17, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29775574/forms-and-phases-in-huntingtin-protein-aggregation
#9
Michael Elbaum
Using a combination of fluorescence microscopy and electron tomography, Peskett et al. (2018), in this issue of Molecular Cell, explore the nucleation of amyloid-like filaments from liquid-like condensates of huntingtin protein exon1 with disease-related polyQ extensions.
May 17, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29775350/charge-fractionalization-in-the-two-channel-kondo-effect
#10
L Aviad Landau, Eyal Cornfeld, Eran Sela
The phenomenon of charge fractionalization describes the emergence of novel excitations with fractional quantum numbers, as predicted in strongly correlated systems such as spin liquids. We elucidate that precisely such an unusual effect may occur in the simplest possible non-Fermi liquid, the two-channel Kondo effect. To bring this concept down to experimental test, we study nonequilibrium transport through a device realizing the charge two-channel Kondo critical point in a recent experiment by Iftikhar et al...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29775314/qm-mm-simulations-with-the-gaussian-electrostatic-model-a-density-based-polarizable-potential
#11
Hatice Gokcan, Eric Granville Kratz, Thomas A Darden, Jean-Philip Piquemal, Gerardo Andres Cisneros
The use of advanced polarizable potentials in Quantum Mechanical/Molecular Mechanical (QM/MM) simulations have been shown to improve the overall accuracy of the calculation. We have developed a density-based potential called the Gaussian Electrostatic Model (GEM), which has been shown to provide very accurate environments for QM wavefunctions in QM/MM. In this contribution we present a new implementation of QM/GEM that extends our implementation to include all components (Coulomb, exchange-repulsion, polarization, and dispersion) for the total inter-molecular interaction energy in QM/MM calculations, except for the charge-transfer term...
May 18, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29775242/mutations-in-mars-identified-in-a-specific-type-of-pulmonary-alveolar-proteinosis-alter-methionyl-trna-synthetase-activity
#12
Martine Comisso, Alice Hadchouel, Jacques de Blic, Marc Mirande
Biallelic missense mutations in MARS are responsible for rare but severe cases of pulmonary alveolar proteinosis (PAP) prevalent on the island of La Réunion. MARS encodes cytosolic methionyl-tRNA synthetase (MetRS), an essential translation factor. The multisystemic effects observed in patients with this form of PAP is consistent with a loss-of-function defect in an ubiquitously expressed enzyme. The pathophysiological mechanisms involved in MARS related PAP are currently unknown. In this work, we analyzed the effect of the PAP related mutations in MARS on the thermal stability and on the catalytic parameters of the MetRS mutants, relative to wild-type...
May 18, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29774784/moderate-alcohol-consumption-is-associated-with-increased-radiological-progression-in-women-but-not-in-men-with-early-rheumatoid-arthritis-results-from-the-espoir-cohort-%C3%A3-tude-et-suivi-des-polyarthrites-indiff%C3%A3-renci%C3%A3-es-r%C3%A3-centes
#13
F Sageloli, J L Quesada, B Fautrel, C Salliot, P Gaudin, A Baillet
OBJECTIVE: We conducted this study to determine whether alcohol consumption influences radiological progression in early rheumatoid arthritis (RA). METHOD: Patients fulfilling the European League Against Rheumatism/American College of Rheumatology 2010 criteria in the early arthritis cohort ESPOIR (Étude et Suivi des Polyarthrites Indifférenciées Récentes) were included in this study. Alcohol consumption was collected at baseline and at each visit. We classified alcohol consumption into three groups: abstinent (0 g/day), moderate (≤ 20 g/day for women, ≤ 30 g/day for men), and abuse (> 20 g/day for women, > 30 g/day for men)...
May 18, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29774525/teaching-social-perception-skills-to-adolescents-with-autism-and-intellectual-disabilities-using-video-based-group-instruction
#14
Tiffany A Stauch, Joshua B Plavnick, Sudha Sankar, Annie C Gallagher
Few interventions focus on teaching social skills to adolescents with autism spectrum disorder (ASD) and intellectual disabilities (ID) that are consistently used during interactions with peers ( Carter et al., 2014). The present study evaluated the effects of video-based group instruction (VGI) on the acquisition of social perception skills of five adolescents with ASD or ID in a public school setting. Social perception involves observing affective behaviors of others, discriminating relevant environmental stimuli, and differentially reinforcing the affective behavior of another person...
May 17, 2018: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/29774496/correction-to-molecular-characterization-of-a-human-group-c-rotavirus-detected-first-in-turkey
#15
Marcelo Takahiro Mitui, Gulendam Bozdayi, Buket Dalgic, Ilknur Bostanci, Akira Nishizono, Kamruddin Ahmed
This article was unintentionally published twice in this journal, by the same authors. Following should be considered the version of record and used for citation purposes: "Mitui, M.T., Bozdayi, G., Dalgic, B. et al. Molecular characterization of a human group C rotavirus detected first in Turkey, Virus Genes (2009) 39, 2, 157-164, https://doi.org/10.1007/s11262-009-0420-8 ". The duplicate "Mitui, M.T., Bozdayi, G., Dalgic, B. et al. Molecular characterization of a human group C rotavirus detected first in Turkey, Virus Genes (2009), https://doi...
May 17, 2018: Virus Genes
https://www.readbyqxmd.com/read/29774464/eculizumab-in-stec-hus-need-for-a-proper-randomized-controlled-trial
#16
Sebastian Loos, Jun Oh, Markus J Kemper
Hemolytic uremic syndrome caused by Shiga toxin-producing E. coli (STEC-HUS) is often associated with a severe morbidity including neurological involvement and a mortality of 1-5%. Although STEC-HUS is often self-limited, improvement of treatment strategies is needed for cases with complications and, among others, plasma exchange/plasmapheresis and use of antibiotics have been advocated. With the availability of the complement blocker eculizumab, now a standard treatment of atypical HUS, several series have addressed its use in STEC-HUS, with variable response; randomized controlled trials are lacking...
May 17, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29774325/effect-of-halogen-dopants-on-the-properties-of-li-2-o-2-is-chloride-special
#17
Henry A Cortes, Verónica L Vildosola, María Andrea Barral, Horacio R Corti
There is consensus on the fact that one of the main limitations of Li air batteries (LABs) is the insulating character of Li2O2 and that it becomes crucial to explore new conduction paths. Recent studies indicate that doping with chloride increases the ion conductivity of Li2O2, although to a much lesser extent than expected if chloride is assumed to be a donor dopant [Gerbig et al., Adv. Mater., 2013, 25, 3129]. Subsequently, it has been shown that the addition of lithium chloride, LiCl, to the battery electrolyte increases its discharge capacity, while this effect is not observed with other halogens [Matsuda et al...
May 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29774046/identification-of-rice-genes-associated-with-enhanced-cold-tolerance-by-comparative-transcriptome-analysis-with-two-transgenic-rice-plants-overexpressing-dacbf4-or-dacbf7-isolated-from-antarctic-flowering-plant-deschampsia-antarctica
#18
Mi Young Byun, Li Hua Cui, Jungeun Lee, Hyun Park, Andosung Lee, Woo Taek Kim, Hyoungseok Lee
Few plant species can survive in Antarctica, the harshest environment for living organisms. Deschampsia antarctica is the only natural grass species to have adapted to and colonized the maritime Antarctic. To investigate the molecular mechanism of the Antarctic adaptation of this plant, we identified and characterized D. antarctica C-repeat binding factor 4 ( DaCBF4 ), which belongs to monocot CBF group IV. The transcript level of DaCBF4 in D. antarctica was markedly increased by cold and dehydration stress...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29773837/microbial-networking-in-cancer-when-two-toxins-collide
#19
EDITORIAL
Sarah Tomkovich, Christian Jobin
A recent study by Dejea et al. has demonstrated that two enterotoxigenic bacteria frequently associated with sporadic colorectal cancer, Bacteroides fragilis and pks+ Escherichia coli, are found together in biofilms on tissue from patients with familial adenomatous polyposis. In preclinical mouse models, these two bacteria and their corresponding toxins work synergistically to promote colon cancer.
May 18, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29773719/response-to-comment-on-maxima-in-the-thermodynamic-response-and-correlation-functions-of-deeply-supercooled-water
#20
Kyung Hwan Kim, Alexander Späh, Harshad Pathak, Fivos Perakis, Daniel Mariedahl, Katrin Amann-Winkel, Jonas A Sellberg, Jae Hyuk Lee, Sangsoo Kim, Jaehyun Park, Ki Hyun Nam, Tetsuo Katayama, Anders Nilsson
Caupin et al have raised several issues regarding our recent paper on maxima in thermodynamic response and correlation functions in deeply supercooled water. We show that these issues can be addressed without affecting the conclusion of the paper.
May 18, 2018: Science
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