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Jean Mooney, Mark R Lynch, Colin V Prescott, Tracy Clegg, Michael Loughlin, Bernard Hannon, Colm Moore, Richard Faulkner
While resistance to anticoagulant rodenticides is known to occur in many European populations of Norway rat and house mouse, to-date no data is available on the occurrence in Ireland of such resistance. No genetic evidence for the occurrence of resistance was found in 65 Norway rat samples analysed, indicative of an absence, or low prevalence, of resistance in rats in at least the Eastern region of the island of Ireland. The presence of two of the most commonly found amino acid substitutions Leu128Ser and Tyr139Cys associated with house mouse resistance to anticoagulant rodenticides was confirmed...
March 14, 2018: Scientific Reports
Lewis Chan, Vincent Tse
PURPOSE: The mid-urethral synthetic sling (MUS) procedure has become the standard of care for treatment of female stress urinary incontinence. However, a small number of patients will have complications following MUS including failure, obstructive voiding, sling erosion, or chronic pain. This paper discusses the role of 2D and 3D ultrasound imaging in the evaluation of the female patient with complications following placement of a synthetic mid-urethral sling. RESULTS: The MUS is easily visualized as an echogenic structure on ultrasound and can be imaged by transperineal, transvaginal and introital approaches...
March 12, 2018: World Journal of Urology
Esteban Yefi-Quinteros, Catalina Muñoz-San Martín, Antonella Bacigalupo, Juana P Correa, Pedro E Cattan
BACKGROUND: Trypanosoma cruzi is the agent of Chagas disease, a major public health problem in Latin America. Many wild and domestic animals are naturally infected with T. cruzi; rodents are one of the groups which have been consistently detected infected in different countries. The aim of this work was to characterize blood T. cruzi load in naturally infected rodents from a Chagas disease endemic region in Chile. METHODS: Baited traps were set in domestic and peridomestic areas of rural dwellings...
March 12, 2018: Parasites & Vectors
Clement Isaac, Benjamin Igho Igbinosa, John Asekhaen Ohiolei, Catherine Eki Osimen
Some small mammals occur as household pests and harbour a number of parasites that could be of public health importance. This study profiled the helminth and protozoan parasites in trapped small mammals within and around human dwelling places (houses) located across 4 major towns (Auchi, Benin, Ekpoma, and Uromi) and environs in Edo state, Nigeria. Six genera ( Apodemus sp., Crocidura sp., Mastomys natalensis , Mus musculus , Rattus sp., and Sorex sp.) were identified from 502 trapped small mammals. Overall, M...
February 2018: Korean Journal of Parasitology
Ryan J Colquhoun, Mitchel A Magrini, Cody T Haun, Tyler W D Muddle, Patrick M Tomko, Micheal J Luera, Cameron S Mackey, Christopher G Vann, Jeffrey S Martin, Kaelin C Young, Jason M DeFreitas, Michael D Roberts, Nathaniel D M Jenkins
Previous investigations have reported a relationship between skeletal muscle phenotype and motor unit (MU) firing parameters during submaximal contractions. The purpose of the current investigation, however, was to examine the relationships between motor unit firing behavior during a maximal voluntary contraction, Myosin Heavy Chain (MHC) isoform content, and various molecular neuromuscular targets of the vastus lateralis (VL) muscle in resistance-trained men. Ten resistance-trained males completed a trapezoidal ramp contraction up to 100% of their maximal voluntary isometric strength (MVIC)...
March 2018: Physiological Reports
Zita Groó, Péter Szenczi, Oxána Bánszegi, Zsófia Nagy, Vilmos Altbäcker
Huddling with other individuals is an effective way, to reduce heat loss. This cooperative behavior requires that the individuals tolerate each other's presence at least for a certain time or under certain circumstances. In our study, we investigated the effects of ambient temperature and familiarity on the huddling behavior of two closely related mouse species, the mound-building mouse (Mus spicilegus) and the house mouse (Mus musculus musculus). While their geographic distribution overlaps, their social systems differ in many aspects...
March 7, 2018: Behavioural Processes
Neva Škrabar, Leslie M Turner, Luisa F Pallares, Bettina Harr, Diethard Tautz
Two subspecies of the house mouse, Mus musculus domesticus and Mus musculus musculus, meet in a narrow contact zone across Europe. Mice in the hybrid zone are highly admixed, representing the full range of mixed ancestry from the two subspecies. Given the distinct morphologies of these subspecies, these natural hybrids can be used for genome-wide association mapping at sufficiently high resolution to directly infer candidate genes. We focus here on limb bone length differences, which is of special interest for understanding the evolution of developmentally correlated traits...
March 9, 2018: Molecular Ecology Resources
A Ortega-Morales, J A Garza-Hernández, V H González-Álvarez, L M Hernández-Triana, M A Rodríguez-Pérez
Culex (Microculex) daumastocampa Dyar & Knab was originally described by Dyar and Knab (Proc US Nat Mus 35:53-70, 1908) from larvae collected at axils of bromeliads in Port San Felipe, Panama. Culex daumastocampa is found in Colombia, Venezuela, Panama, Suriname, Costa Rica, Nicaragua, Guatemala, and Mexico, although its presence had not been reported suggesting its northernmost distribution. In Mexico, the subgenus Microculex had included Cx. rejector Dyar and Knab, and Cx. imitator Theobald. However, after that collection specimens were re-examined along with other specimens collected during 2016 in Chiapas (all specimens are available in the Culicidae Collection of the Universidad Autonoma Agraria Antonio Narro Unidad Laguna [UAAAN-UL], Mexico)...
March 8, 2018: Neotropical Entomology
Jie Li, Guohai Qi, Yuan Qin, Pei Wang
Objective: The objective of this study is to preliminarily evaluate the feasibility of brass compensator-based intensity-modulated radiation therapy (CB-IMRT). Materials and Methods: Ten patients (three cases of nasopharyngeal cancer, four of esophageal cancer, and three of rectal cancer) who underwent an IMRT treatment planning were selected for this study. The transmission coefficient of brass plates with different thicknesses was measured under a 6 MV photon beam used in the treatment planning system, and the equation for thickness computation was fitted out...
January 2018: Journal of Cancer Research and Therapeutics
Bin Yu, Xinguang Chen, Yan Wang
BACKGROUND: Marijuana and tobacco are considered two closely related substances. It is of great significance to understand the mutual impact of marijuana and cigarette use when more states in the US have legalized marijuana use. OBJECTIVE: This study aims to investigate the transitions between marijuana and cigarette use among adolescents and emerging adults. METHOD: Guided by the probabilistic discrete events systems (PDES) theory, a five-stage model with 21 transition paths was constructed to quantify dynamic transitions between marijuana and cigarette use...
March 7, 2018: American Journal of Drug and Alcohol Abuse
Jeevitaa Kshersagar, Ravi Kshirsagar, Shashikant Desai, Raghvendra Bohara, Meghnad Joshi
Direct application of amnion has greater risk of immunological rejection and infection. Decellularization is an effective method to lower the risk of immune complications and infections. The bioreactor assembly with multiple cassettes was designed for decellurization of multiple amnions with different cell types simultaneously in single run. A detergent-based protocol was modified to remove all cellular components from amnion and diminish the DNA content to render it non-immunogenic. Amnion (n = 10) were treated with 2% sodium dodecyl sulphate (SDS), 5% dimethyl sulfoxide (DMSO) and 2% sodium deoxycholeate (SD)...
March 5, 2018: Cell and Tissue Banking
Baozhou Sun, Dao Lam, Deshan Yang, Kevin Grantham, Tiezhi Zhang, Sasa Mutic, Tianyu Zhao
PURPOSE: Clinical treatment planning systems for proton therapy currently do not calculate monitor units (MUs) in passive scatter proton therapy due to the complexity of the beam delivery systems. Physical phantom measurements are commonly employed to determine the field-specific output factors (OFs) but are often subject to limited machine time, measurement uncertainties and intensive labor. In this study, a machine learning based approach was developed to predict output (cGy/MU) and derive MUs, incorporating the dependencies on gantry angle and field size for a single-room proton therapy system...
March 3, 2018: Medical Physics
Simone Santoro, Cristina Sanchez-Suarez, Carlos Rouco, L Javier Palomo, M Carmen Fernández, Maura B Kufner, Sacramento Moreno
Climate change affects distribution and persistence of species. However, forecasting species' responses to these changes requires long-term data series that are often lacking in ecological studies. We used 15 years of small mammal trapping data collected between 1978 and 2015 in 3 areas at Doñana National Park (southwest Spain) to (i) describe changes in species composition and (ii) test the association between local climate conditions and size of small mammal populations. Overall, 5 species were captured: wood mouse Apodemus sylvaticus , algerian mouse Mus spretus , greater white-toothed shrew Crocidura russula , garden dormouse Eliomys quercinus , and black rat Rattus rattus ...
October 2017: Current Zoology
Mousa Khosravani
Historically, rodents-ectoparasites are responsible for many diseases in human and domestic animal communities because they are well-adapted to the environment and nutritional resources. In addition, ectoparasites can affect the reproductive rates, ecological fitness and the dispersal pattern of their hosts. Data was compiled through all publications relating to ectoparasites fauna from Iranian rodents. Host specificity, rodent-parasites interaction, geographical distribution, ecological trends as well as the medical or veterinary importance of ectoparasites are considered in this review...
March 2018: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Weiqing Zheng, Yangqing Liu, Huiying Tao, Zifen Li, Xuenan Xuan, Xiaoqing Liu, Paul Franck Adjou Moumouni, Yayun Wu, Wenqing Liu, Haiying Chen
In this study, systematic surveillance of rodent population in Nanchang of China and determination of Anaplasma phagocytophilum infection in rodents were performed. Between 2011 and 2015, 110,084 rodent snap traps were set in 4 Counties and the city center of Nanchang, China. Finally, 942 rodents were captured with the relative densities of 0.86%. The densities varied considerably by geographical difference and Anyi was the most rodent-infested County. Frequently captured rodents were sewer rats (Rattus norvegicus), house mice (Mus musculus) and Rattus flavipectus...
February 28, 2018: Japanese Journal of Infectious Diseases
Marcella G Willis-Gray, Katherine E Husk, Taylor J Brueseke, Jennifer M Wu, Alexis A Dieter
OBJECTIVES: Our primary objective was to evaluate age as a predictor of postanesthesia care unit (PACU) opioid administration in women undergoing reconstructive pelvic surgery. Our secondary objective was to identify additional predictors of PACU opioid administration. METHODS: We conducted a retrospective cohort study of women undergoing outpatient urogynecologic surgery for pelvic organ prolapse and/or stress urinary incontinence between September 2015 to October 2016 at 1 academic medical center...
February 27, 2018: Female Pelvic Medicine & Reconstructive Surgery
Véronique Schulten, Luise Westernberg, Giovanni Birrueta, John Sidney, Sinu Paul, Paula Busse, Bjoern Peters, Alessandro Sette
Mouse allergy has become increasingly common, mainly affecting laboratory workers and inner-city households. To date, only one major allergen, namely Mus m 1, has been described. We sought to identify T cell targets in mouse allergic patients. PBMC from allergic donors were expanded with either murine urine or epithelial extract and subsequently screened for cytokine production (IL-5 and IFNγ) in response to overlapping peptides spanning the entire Mus m 1 sequence, peptides from various Mus m 1 isoforms [major urinary proteins (MUPs)], peptides from mouse orthologs of known allergens from other mammalian species and peptides from proteins identified by immunoproteomic analysis of IgE/IgG immunoblots of mouse urine and epithelial extracts...
2018: Frontiers in Immunology
Mingfang Guo, Erliang Huang, Xianfeng Liu, Ying Tang
BACKGROUND: The aim of this study was to compare the dosimetric parameters, clinical complications, and efficacy of volumetric modulated arc therapy (VMAT) and fixed-field intensity-modulated radiotherapy (f-IMRT) in radical radiotherapy for cervical cancer without lymphadenectasis. METHODS: 84 cervical cancer patients undergoing treatment with VMAT and f-IMRT were selected. Dose-volume histograms were used to evaluate the dose distribution in the planning target volume (PTV) and organs at risk...
2018: Oncology Research and Treatment
Ryan S Wible, Chidambaram Ramanathan, Carrie Hayes Sutter, Kristin M Olesen, Thomas W Kensler, Andrew C Liu, Thomas R Sutter
Diurnal oscillation of intracellular redox potential is known to couple metabolism with the circadian clock, yet the responsible mechanisms are not well understood. We show here that chemical activation of NRF2 modifies circadian gene expression and rhythmicity, with phenotypes similar to genetic NRF2 activation. Loss of Nrf2 function in mouse fibroblasts, hepatocytes and liver also altered circadian rhythms, suggesting that NRF2 stoichiometry and/or timing of expression are important to timekeeping in some cells...
February 26, 2018: ELife
Yingwen Zhao, Guangyuan Fu, Jun Wang, Maozu Guo, Guoxian Yu
Gene Ontology (GO) uses structured vocabularies (or terms) to describe the molecular functions, biological roles, and cellular locations of gene products in a hierarchical ontology. GO annotations associate genes with GO terms and indicate the given gene products carrying out the biological functions described by the relevant terms. However, predicting correct GO annotations for genes from a massive set of GO terms as defined by GO is a difficult challenge. To combat with this challenge, we introduce a Gene Ontology Hierarchy Preserving Hashing (HPHash) based semantic method for gene function prediction...
February 22, 2018: Genomics
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