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https://www.readbyqxmd.com/read/29148230/personality-traits-such-as-neuroticism-and-disability-predict-psychological-distress-in-medically-unexplained-symptoms-a-three-year-experience-from-a-single-centre
#1
Vikas Menon, Balasubramanian Shanmuganathan, Jaiganesh Selvapandian Thamizh, Anand Babu Arun, Pooja Patnaik Kuppili, Siddharth Sarkar
BACKGROUND: People with medically unexplained symptoms (MUS) may have psychological co-morbidities. AIMS: Our objectives were to assess the rates and identify correlates of psychological distress in MUS. METHODS: A total of 171 subjects with MUS seeking treatment at a tertiary care facility were assessed over a 3-year period. Psychological distress was assessed using the Tamil version of General Health Questionnaire-12. Apart from socio-demographic factors, personality, coping, perceived social support and subjective disability were assessed using standard instruments...
November 17, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/29138238/a-resource-for-the-allele-specific-analysis-of-dna-methylation-at-multiple-genomically-imprinted-loci-in-mice
#2
Jadiel A Wasson, Onur Birol, David J Katz
Genomically imprinted loci are expressed mono-allelically dependent upon the parent of origin. Their regulation not only illuminates how chromatin regulates gene expression but also how chromatin can be reprogrammed every generation. Because of their distinct parent of origin regulation, analysis of imprinted loci can be difficult. Single nucleotide polymorphisms (SNPs) are required to accurately assess these elements allele-specifically. However, publicly available SNP databases lack robust verification, making analysis of imprinting difficult...
November 14, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29129138/the-role-of-zn-complex-in-binding-of-transcription-factors-to-operator-dna-mouse%C3%A2-egr-1-from-the-cys2his2-family
#3
Y N Chirgadze, E A Boshkova, R V Polozov, V S Sivozhelezov, A V Dzyabchenko, M B Kuzminsky, V A Stepanenko, V V Ivanov
The mouse factor Zif268, known also as early growth response protein EGR-1, is a classical representative for the Cys2His2 transcription factor family. It is required for binding the RNA polymerase with operator dsDNA to initialize the transcription process. We have shown that only in this family of total six Zn-finger protein families the Zn complex plays a significant role in the protein-DNA binding. Electrostatic feature of this complex in the binding of factor Zif268 from Mus musculus with operator DNA has been considered...
November 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29125239/hippocampal-sparing-approach-in-fractionated-stereotactic-brain-vmat-radio-therapy-a-retrospective-feasibility-analysis
#4
Maria Daniela Falco, Stefano Giancaterino, Marco D'Andrea, Ramon Gimenez De Lorenzo, Marianna Trignani, Luciana Caravatta, Clelia Di Carlo, Saide Di Biase, Albina Allajbej, Domenico Genovesi
Volumetric Modulated Arc Therapy (VMAT) techniques for fractioned stereotactic brain radiotherapy (FSBRT) can achieve highly conformal dose distribution to intracranial lesions. However, they can potentially increase the dose to hippocampus (H) causing neurocognitive toxicity during the first four months after irradiation. The purpose of this study was to assess the feasibility of hippocampal-sparing (HS) treatment plans in 22 patients with brain metastasis treated with VMAT technique. Firstly, we retrospectively analyzed hippocampal doses in all 22 VMAT original (not hippocampal-sparing, NHS) plans...
November 10, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29125234/evaluation-of-clinically-applied-treatment-beams-with-respect-to-bunker-shielding-parameters-for-a-cyberknife-m6
#5
Dominik Henzen, Daniel Schmidhalter, Claudia Christina Zanella, Werner Volken, Paul-Henry Mackeprang, Marco Malthaner, Michael Karl Fix, Peter Manser
Compared to a conventional linear accelerator, the Cyberknife (CK) is a unique system with respect to radiation protection shielding and the variety and number of non-coplanar beams are two key components regarding this aspect. In this work, a framework to assess the direction distribution and modulation factor (MF) of clinically applied treatment beams of a CyberKnife M6 is developed. Database filtering options allow studying the influence of different parameters such as collimator types, treatment sites or different bunker sizes...
November 10, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29110925/a-novel-imrt-planning-study-by-using-the-fixed-jaw-method-in-the-treatment-of-peripheral-lung-cancer-with-mediastinal-lymph-node-metastasis
#6
Hao Wang, Hua Chen, Hengle Gu, Yan Shao, Xuwei Cai, Xiaolong Fu, Zhiyong Xu
Intensity-modulated radiotherapy (IMRT) is an important technology in cancer radiotherapy. In the current planning system, such as in the Pinnacle(3) system, jaw positions are automatically set to cover all target volumes, and many medical centers in developing countries are not equipped with linear accelerators with a jaw tracing function. As solitary lesions are often located in patients, the resulting radiation leakage and transmission increase the dose exposure in surrounding critical organs, although blocked by multileaf collimator (MLC) leaves...
October 27, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29106372/53bp1-and-brca1-control-pathway-choice-for-stalled-replication-restart
#7
Yixi Xu, Shaokai Ning, Zheng Wei, Ran Xu, Xinlin Xu, Mengtan Xing, Rong Guo, Dongyi Xu
The cellular pathways that restart stalled replication forks are essential for genome stability and tumor prevention. However, how many of these pathways exist in cells and how these pathways are selectively activated remain unclear. Here, we describe two major fork restart pathways, and demonstrate that their selection is governed by 53BP1 and BRCA1, which are known to control the pathway choice to repair double-strand DNA breaks (DSBs). Specifically, 53BP1 promotes a fork cleavage-free pathway, whereas BRCA1 facilitates a break-induced replication (BIR) pathway coupled with SLX-MUS complex-mediated fork cleavage...
November 6, 2017: ELife
https://www.readbyqxmd.com/read/29103271/chigger-mite-acari-trombiculidae-survey-of-rodents-in-shandong-province-northern-china
#8
Xiao-Dan Huang, Peng Cheng, Yu-Qiang Zhao, Wen-Juan Li, Jiu-Xu Zhao, Hong-Mei Liu, Jing-Xuan Kou, Mao-Qing Gong
Chigger mites are parasites of rodents and other vertebrates, invertebrates, and other arthropods, and are the only vectors of scrub typhus, in addition to other zoonoses. Therefore, investigating their distribution, diversity, and seasonal abundance is important for public health. Rodent surveillance was conducted at 6 districts in Shandong Province, northern China (114-112°E, 34-38°N), from January to December 2011. Overall, 225/286 (78.7%) rodents captured were infested with chigger mites. A total of 451 chigger mites were identified as belonging to 5 most commonly collected species and 3 genera in 1 family...
October 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29101373/ecological-and-sanitary-impacts-of-bacterial-communities-associated-to-biological-invasions-in-african-commensal-rodent-communities
#9
Christophe Diagne, Maxime Galan, Lucie Tamisier, Jonathan d'Ambrosio, Ambroise Dalecky, Khalilou Bâ, Mamadou Kane, Youssoupha Niang, Mamoudou Diallo, Aliou Sow, Philippe Gauthier, Caroline Tatard, Anne Loiseau, Sylvain Piry, Mbacké Sembène, Jean-François Cosson, Nathalie Charbonnel, Carine Brouat
Changes in host-parasite ecological interactions during biological invasion events may affect both the outcome of invasions and the dynamics of exotic and/or endemic infections. We tested these hypotheses, by investigating ongoing house mouse (Mus musculus domesticus) and black rat (Rattus rattus) invasions in Senegal (West Africa). We used a 16S gene rRNA amplicon sequencing approach to study potentially zoonotic bacterial communities in invasive and native rodents sampled along two well-defined independent invasion routes...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29098971/-the-prognosis-of-medically-unexplained-symptoms
#10
D J C Hanssen, H Knoop, J G M Rosmalen
- The condition where someone has physical symptoms for a number of weeks for which no clear somatic cause can be found, is known as medically unexplained symptoms (MUS).- In this article we give an overview of current insights into the prognosis of MUS.- Extensive somatic testing in patients diagnosed with MUS by a physician, rarely results in a somatic diagnosis.- In approximately half of these patients, MUS disappear spontaneously within one year.- Symptom-related characteristics - such as experiencing multiple physical symptoms simultaneously-, and psychological characteristics - such as unhelpful thoughts - are predictors of an unfavourable prognosis for MUS...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29097405/the-evolution-of-gene-specific-transcriptional-noise-is-driven-by-selection-at-the-pathway-level
#11
Gustavo Valadares Barroso, Natasa Puzovic, Julien Y Dutheil
Biochemical reactions within individual cells result from the interactions of molecules, typically in small numbers. Consequently, the inherent stochasticity of binding and diffusion processes generate noise along the cascade that leads to the synthesis of a protein from its encoding gene. As a result, isogenic cell populations display phenotypic variability even in homogeneous environments. The extent and consequences of this stochastic gene expression have only recently been assessed on a genome-wide scale, in particular owing to the advent of single cell transcriptomics...
November 2, 2017: Genetics
https://www.readbyqxmd.com/read/29093681/quantitative-and-systems-pharmacology-3-network-based-identification-of-new-targets-for-natural-products-enables-potential-uses-in-aging-associated-disorders
#12
Jiansong Fang, Li Gao, Huili Ma, Qihui Wu, Tian Wu, Jun Wu, Qi Wang, Feixiong Cheng
Aging that refers the accumulation of genetic and physiology changes in cells and tissues over a lifetime has been shown a high risk of developing various complex diseases, such as neurodegenerative disease, cardiovascular disease and cancer. Over the past several decades, natural products have been demonstrated as anti-aging interveners via extending lifespan and preventing aging-associated disorders. In this study, we developed an integrated systems pharmacology infrastructure to uncover new indications for aging-associated disorders by natural products...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29091026/genomic-regions-controlling-shape-variation-in-the-first-upper-molar-of-the-house-mouse
#13
Luisa F Pallares, Ronan Ledevin, Sophie Pantalacci, Leslie M Turner, Eirikur Steingrimsson, Sabrina Renaud
Numerous loci of large effect have been shown to underlie phenotypic variation between species. However, loci with subtle effects are presumably more frequently involved in microevolutionary processes but have rarely been discovered. We explore the genetic basis of shape variation in the first upper molar of hybrid mice between Mus musculus musculus and M. m. domesticus. We performed the first genome-wide association study for molar shape and used 3D surface morphometrics to quantify subtle variation between individuals...
November 1, 2017: ELife
https://www.readbyqxmd.com/read/29077143/-neuromodulation-can-be-effective-in-patients-with-medically-unexplained-symptoms
#14
M van Beilen, H Tieleman
BACKGROUND: Neuromodulation may influence abnormal brain activation patterns in medically unexplained symptoms (MUS). AIM: To assess the importance and direction of future studies on patients with MUS. METHOD: We describe the results of the first studies on patients with functional neurological symptom disorder (fNSD) and chronic pain. RESULTS: Clinically relevant improvements in the health condition of a substantial number of patients with fnsd have been reported...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29077081/mus-musculus-ad-astra
#15
Ellen P Neff
No abstract text is available yet for this article.
October 27, 2017: Lab Animal
https://www.readbyqxmd.com/read/29076046/optimization-of-c16-and-c18-fatty-alcohol-production-by-an-engineered-strain-of-lipomyces-starkeyi
#16
Bonnie A McNeil, David T Stuart
The oleaginous yeast Lipomyces starkeyi was engineered for the production of long-chain fatty alcohols by expressing a fatty acyl-CoA reductase, mFAR1, from Mus musculus. The optimal conditions for production of fatty alcohols by this strain were investigated. Increased carbon-to-nitrogen ratios led to efficient C16 and C18 fatty alcohol production from glucose, xylose and glycerol. Batch cultivation resulted in a titer of 1.7 g/L fatty alcohol from glucose which represents a yield of 28 mg of fatty alcohols per gram of glucose...
October 26, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29075571/quantitative-muscle-ultrasound-is-useful-for-evaluating-secondary-axonal-degeneration-in-chronic-inflammatory-demyelinating-polyneuropathy
#17
Keiichi Hokkoku, Kiyoshi Matsukura, Yudai Uchida, Midori Kuwabara, Yuichi Furukawa, Hiroshi Tsukamoto, Yuki Hatanaka, Masahiro Sonoo
INTRODUCTION: In chronic inflammatory demyelinating polyneuropathy (CIDP), exclusion of secondary axonal degeneration is challenging with conventional methods such as nerve conduction study (NCS), needle electromyography, and nerve biopsy. Increased echo intensity (EI) and decreased muscle thickness (MT) identified on muscle ultrasound (MUS) examination represent muscle denervation due to axonal degeneration in neurogenic disorders, suggesting MUS as a new tool to detect secondary axonal degeneration in patients with CIDP...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29069483/protein-profile-of-mouse-ovarian-follicles-grown-in-vitro
#18
Amandine Anastácio, Kenny A Rodriguez-Wallberg, Solenne Chardonnet, Cédric Pionneau, Christian Fédérici, Teresa Almeida Santos, Catherine Poirot
STUDY QUESTION: Could the follicle proteome be mapped by identifying specific proteins that are common or differ between three developmental stages from the secondary follicle to the antrum-like stage? SUMMARY ANSWER: From a total of 1401 proteins identified in the follicles, 609 were common to the three developmental stages investigated and 444 were found uniquely at one of the stages. WHAT IS KNOWN ALREADY: The importance of the follicle as a functional structure has been recognized; however, up-to-date the proteome of the whole follicle has not been described...
October 23, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29069466/mga-repository-a-curated-data-resource-for-chip-seq-and-other-genome-annotated-data
#19
René Dréos, Giovanna Ambrosini, Romain Groux, Rouayda Cavin Périer, Philipp Bucher
The Mass Genome Annotation (MGA) repository is a resource designed to store published next generation sequencing data and other genome annotation data (such as gene start sites, SNPs, etc.) in a completely standardised format. Each sample has undergone local processing in order the meet the strict MGA format requirements. The original data source, the reformatting procedure and the biological characteristics of the samples are described in an accompanying documentation file manually edited by data curators...
October 24, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29067438/mirna-140-inhibits-c3h10t1-2-mesenchymal-stem-cell-proliferation-by-targeting-cxcl12-during-transforming-growth-factor-%C3%AE-3-induced-chondrogenic-differentiation
#20
Qingde Wa, Yi Liu, Shuai Huang, Peiheng He, Jianwei Zuo, Xing Li, Ziqing Li, Liming Dong, Jiachen Peng, Shuhong Wu, Fang Chen, Dongfeng Cai, Xuenong Zou, Wenbo Liao
The aim of the present study was to investigate the role of microRNA (miRNA or miR)-140 in C3H10T1/2 mesenchymal stem cells (MSCs). Cluster analysis was used to evaluate the miRNA expression profile. The expression level of miRNA‑140 was validated by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). TargetScan and microRNA.org databases were used to predict target miRNAs and cartilage‑associated target genes. Binding sites between miR‑140 and the target gene were predicted by bioinformatics software...
August 2017: Molecular Medicine Reports
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