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https://www.readbyqxmd.com/read/28340444/comparative-effectiveness-of-dual-action-versus-single-action-antidepressants-for-the-treatment-of-depression-in-people-living-with-hiv-aids
#1
Jon C Mills, Jeffrey S Harman, Robert L Cook, Nicole M Marlow, Christopher A Harle, R Paul Duncan, Angela M Bengtson, Brian W Pence
BACKGROUND: Depression is the most common psychiatric comorbidity among people living with HIV/AIDS (PLWHA). Little is known about the comparative effectiveness between different types of antidepressants used to treat depression in this population. We compared the effectiveness of dual-action and single-action antidepressants in PLWHA for achieving remission from depression. METHODS: We used data from the Centers for AIDS Research Network of Integrated Clinic Systems to identify 1175 new user dual-action or single-action antidepressant treatment episodes occurring from 2005 to 2014 for PLWHA diagnosed with depression...
March 19, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28334728/does-emergency-presentation-of-cancer-represent-poor-performance-in-primary-care-insights-from-a-novel-analysis-of-linked-primary-and-secondary-care-data
#2
Peter Murchie, Sarah M Smith, Michael S Yule, Rosalind Adam, Melanie E Turner, Amanda J Lee, Shona Fielding
BACKGROUND: People diagnosed with cancer following emergency presentation have poorer short-term survival. To what extent this signifies a missed opportunity for earlier diagnosis in primary care remains unclear as little detailed data exist on the patient/general practitioner interaction beforehand. METHODS: Analysis of primary care and regional data for 1802 cancer patients from Northeast Scotland. Adjusted odds ratios (OR) and 95% confidence intervals (CIs) for patient and GP practice predictors of emergency presentation...
March 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28330521/can-trainees-design-and-deliver-a-national-audit-of-epistaxis-management-a-pilot-of-a-secure-web-based-audit-tool-and-research-trainee-collaboratives
#3
N Mehta, R J Williams, M E Smith, A Hall, J C Hardman, L Cheung, M P Ellis, J M Fussey, R Lakhani, O McLaren, P C Nankivell, N Sharma, W Yeung, S Carrie, C Hopkins
OBJECTIVE: To investigate the feasibility of a national audit of epistaxis management led and delivered by a multi-region trainee collaborative using a web-based interface to capture patient data. METHODS: Six trainee collaboratives across England nominated one site each and worked together to carry out this pilot. An encrypted data capture tool was adapted and installed within the infrastructure of a university secure server. Site-lead feedback was assessed through questionnaires...
March 23, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28328291/evaluation-of-multi-parameter-test-statistics-for-multiple-imputation
#4
Yu Liu, Craig K Enders
In Ordinary Least Square regression, researchers often are interested in knowing whether a set of parameters is different from zero. With complete data, this could be achieved using the gain in prediction test, hierarchical multiple regression, or an omnibus F test. However, in substantive research scenarios, missing data often exist. In the context of multiple imputation, one of the current state-of-art missing data strategies, there are several different analogous multi-parameter tests of the joint significance of a set of parameters, and these multi-parameter test statistics can be referenced to various distributions to make statistical inferences...
March 22, 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/28327581/the-early-life-environment-of-a-pig-shapes-the-phenotypes-of-its-social-partners-in-adulthood
#5
L Canario, N Lundeheim, P Bijma
Social interactions among individuals are abundant, both in natural and domestic populations, and may affect phenotypes of individuals. Recent research has demonstrated that the social effect of an individual on the phenotype of its social partners may have a genetic component, known as an indirect genetic effect (IGE). Little is known, however, of nongenetic factors underlying such social effects. Early-life environments often have large effects on phenotypes of the individuals themselves later in life. Offspring development in many mammalian species, for example, depends on interactions with the mother and siblings...
March 22, 2017: Heredity
https://www.readbyqxmd.com/read/28325604/early-prediction-of-radiotherapy-induced-parotid-shrinkage-and-toxicity-based-on-ct-radiomics-and-fuzzy-classification
#6
Marco Pota, Elisa Scalco, Giuseppe Sanguineti, Alessia Farneti, Giovanni Mauro Cattaneo, Giovanna Rizzo, Massimo Esposito
MOTIVATION: Patients under radiotherapy for head-and-neck cancer often suffer of long-term xerostomia, and/or consistent shrinkage of parotid glands. In order to avoid these drawbacks, adaptive therapy can be planned for patients at risk, if the prediction is obtained timely, before or during the early phase of treatment. Artificial intelligence can address the problem, by learning from examples and building classification models. In particular, fuzzy logic has shown its suitability for medical applications, in order to manage uncertain data, and to build transparent rule-based classifiers...
March 18, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28318757/-imputing-missing-data-in-public-health-general-concepts-and-application-to-dichotomous-variables
#7
Gilma Hernández, David Moriña, Albert Navarro
The presence of missing data in collected variables is common in health surveys, but the subsequent imputation thereof at the time of analysis is not. Working with imputed data may have certain benefits regarding the precision of the estimators and the unbiased identification of associations between variables. The imputation process is probably still little understood by many non-statisticians, who view this process as highly complex and with an uncertain goal. To clarify these questions, this note aims to provide a straightforward, non-exhaustive overview of the imputation process to enable public health researchers ascertain its strengths...
March 15, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28283373/dynamics-affecting-the-risk-of-silent-circulation-when-oral-polio-vaccination-is-stopped
#8
J S Koopman, C J Henry, J H Park, M C Eisenberg, E L Ionides, J N Eisenberg
Waning immunity could allow transmission of polioviruses without causing poliomyelitis by promoting silent circulation (SC). Undetected SC when oral polio vaccine (OPV) use is stopped could cause difficult to control epidemics. Little is known about waning. To develop theory about what generates SC, we modeled a range of waning patterns. We varied both OPV and wild polio virus (WPV) transmissibility, the time from beginning vaccination to reaching low polio levels, and the infection to paralysis ratio (IPR)...
March 1, 2017: Epidemics
https://www.readbyqxmd.com/read/28281028/a-proposal-for-a-portal-to-make-earth-s-microbial-diversity-easily-accessible-and-searchable
#9
Boris A Vinatzer, Long Tian, Lenwood S Heath
Estimates of the number of bacterial species range from 10(7) to 10(12). At the pace at which descriptions of new species are currently being published, the description of all bacterial species on earth will only be completed in thousands of years. However, even if one day all species were named and described, these names and descriptions would still be of little practical value unless they could be easily searched and accessed, so that novel strains could be easily identified as members of any of these species...
March 9, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28280845/-function-of-prosthesis-components-in-lower-limb-amputees-with-bone-anchored-percutaneous-implants-biomechanical-aspects
#10
S Blumentritt
BACKGROUND: Bone anchorage of an artificial limb has been proven to be an alternative intervention for amputees when prosthesis use is seriously reduced because of stump problems. Little is known about how prosthesis components interact with bone and joints and which potential the optimum use provides with respect to quality of treatment of leg amputees. OBJECTIVE: Does osseointegration influence the motor activity of residual limbs differently compared with socket prostheses? How should prosthesis components be aligned? What type of prosthetic knee joints should be preferred in transfemoral amputees? MATERIAL AND METHODS: Transfer of biomechanical knowledge of socket prosthetics to bone-anchored prostheses...
March 9, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28279948/remote-monitoring-of-hypertension-diseases-in-pregnancy-a-pilot-study
#11
Dorien Lanssens, Thijs Vandenberk, Christophe Jp Smeets, Hélène De Cannière, Geert Molenberghs, Anne Van Moerbeke, Anne van den Hoogen, Tiziana Robijns, Sharona Vonck, Anneleen Staelens, Valerie Storms, Inge M Thijs, Lars Grieten, Wilfried Gyselaers
BACKGROUND: Although remote monitoring (RM) has proven its added value in various health care domains, little is known about the remote follow-up of pregnant women diagnosed with a gestational hypertensive disorders (GHD). OBJECTIVE: The aim of this study was to evaluate the added value of a remote follow-up program for pregnant women diagnosed with GHD. METHODS: A 1-year retrospective study was performed in the outpatient clinic of a 2nd level prenatal center where pregnant women with GHD received RM or conventional care (CC)...
March 9, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28278378/subsequent-injuries-are-more-common-than-injury-recurrences
#12
Caroline F Finch, Jill Cook, Breanne E Kunstler, Muhammad Akram, John Orchard
BACKGROUND: It is known that some people can, and do, sustain >1 injury over a playing season. However, there is currently little high-quality epidemiological evidence about the risk of, and relationships between, multiple and subsequent injuries. PURPOSE: To describe the subsequent injuries sustained by Australian Football League (AFL) players over 1 season, including their most common injury diagnoses. STUDY DESIGN: Cohort study; Level of evidence, 3...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28276110/adjustment-for-survey-non-representativeness-using-record-linkage-refined-estimates-of-alcohol-consumption-by-deprivation-in-scotland
#13
Emma Gorman, Alastair H Leyland, Gerry McCartney, Srinivasa Vittal Katikireddi, Lisa Rutherford, Lesley Graham, Mark Robinson, Linsay Gray
BACKGROUND AND AIMS: Analytical approaches to addressing survey non-participation bias typically only use demographic information to improve estimates. We applied a novel methodology which uses health information from data linkage to adjust for non-representativeness. We illustrate the method by presenting adjusted alcohol consumption estimates for Scotland. DESIGN: Data on consenting respondents to the Scottish Health Surveys (SHeSs) 1995-2010 were confidentially linked to routinely-collected hospital admission and mortality records...
March 9, 2017: Addiction
https://www.readbyqxmd.com/read/28272103/impact-of-procedural-specialty-on-maternity-leave-and-career-satisfaction-among-female-physicians
#14
Rebecca E Scully, Jennifer S Davids, Nelya Melnitchouk
OBJECTIVE: The aim of this study was to perform a large-scale, national survey of physician mothers to define the personal, professional, and financial impact of maternity leave and its relationship to career satisfaction for female physicians in procedural and nonprocedural fields. SUMMARY OF BACKGROUND DATA: Little is known about the impact of maternity leave on early career female physicians or how childbearing affects career satisfaction. METHODS: A nationwide sample of physician mothers completed a 45-question anonymous, secure, online questionnaire regarding the impact of pregnancy and childbearing...
March 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28268241/estimating-data-from-figures-with-a-web-based-program-considerations-for-a-systematic-review
#15
Brittany U Burda, Elizabeth A O'Connor, Elizabeth M Webber, Nadia Redmond, Leslie A Perdue
BACKGROUND: Systematic reviewers often encounter incomplete or missing data, and the information desired may be difficult to obtain from a study author. Thus, systematic reviewers may have to resort to estimating data from figures with little or no raw data in a study's corresponding text or tables. METHODS: We discuss a case study in which participants used a publically available Web-based program, called webplotdigitizer, to estimate data from 2 figures. We evaluated and used the intraclass coefficient and the accuracy of the estimates to the true data to inform considerations when using estimated data from figures in systematic reviews...
March 7, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/28263396/pregnancy-experiences-of-female-sex-workers-in-adama-city-ethiopia-complexity-of-partner-relationships-and-pregnancy-intentions
#16
Eileen A Yam, Aklilu Kidanu, Brady Burnett-Zieman, Nanlesta Pilgrim, Jerry Okal, Assefa Bekele, Daniel Gudeta, Georgina Caswell
Research and programs for female sex workers (FSWs) tend to focus exclusively on HIV prevention, with little attention paid to how pregnancy affects their lives. We examine the circumstances surrounding pregnancy and childbirth among women selling sex in Ethiopia. In Adama City, researchers asked 30 FSWs aged 18 and older who had ever been pregnant to participate in in-depth interviews. The women reported on pregnancies experienced both before and after they had begun selling sex. They identified some of the fathers as clients, former partners, and current partners, but they did not know the identities of the other fathers...
March 6, 2017: Studies in Family Planning
https://www.readbyqxmd.com/read/28259351/surgical-volume-and-postoperative-mortality-rate-at-a-referral-hospital-in-western-uganda-measuring-the-lancet-commission-on-global-surgery-indicators-in-low-resource-settings
#17
Geoffrey A Anderson, Lenka Ilcisin, Lenard Abesiga, Ronald Mayanja, Noralis Portal Benetiz, Joseph Ngonzi, Peter Kayima, Mark G Shrime
BACKGROUND: The Lancet Commission on Global Surgery recommends that every country report its surgical volume and postoperative mortality rate. Little is known, however, about the numbers of operations performed and the associated postoperative mortality rate in low-income countries or how to best collect these data. METHODS: For one month, every patient who underwent an operation at a referral hospital in western Uganda was observed. These patients and their outcomes were followed until discharge...
March 1, 2017: Surgery
https://www.readbyqxmd.com/read/28253677/reconstruction-of-lamb-wave-dispersion-curves-by-sparse-representation-with-continuity-constraints
#18
Wenbo Zhao, Ming Li, Joel B Harley, Yuanwei Jin, José M F Moura, Jimmy Zhu
Ultrasonic Lamb waves are a widely used research tool for nondestructive structural health monitoring. They travel long distances with little attenuation, enabling the interrogation of large areas. To analyze Lamb wave propagation data, it is often important to know precisely how they propagate. Yet, since wave propagation is influenced by many factors, including material properties, temperature, and other varying conditions, acquiring this knowledge is a significant challenge. In prior work, this information has been recovered by reconstructing Lamb wave dispersion curves with sparse wavenumber analysis...
February 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28244279/socioeconomic-disparities-in-the-prevalence-diagnosis-and-control-of-hypertension-in-the-context-of-a-universal-health-insurance-system
#19
Hoo Yeon Lee
A lower use of preventive intervention in low socioeconomic populations has been described in countries with universal coverage health care systems, but little is known about the possible socioeconomic inequalities in secondary prevention in a universal health insurance system. Data from the 2010-2013 Korea National Health and Nutrition Examination Survey, a nationwide survey, were analyzed. A total of 20,044 subjects older than 30 years of age were included after excluding subjects with missing data. Prevalence ratios were calculated using Poisson regression models with robust variance to explore factors associated with the prevalence, unawareness, and inappropriate control of hypertension...
April 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28241176/predictors-of-obstructive-sleep-apnea-severity-in-adolescents
#20
Mark Baker, Brian Scott, Romaine F Johnson, Ron B Mitchell
Importance: Untreated obstructive sleep apnea has severe health consequences, yet little is known about predictors of sleep apnea severity in the adolescent population. Objective: To evaluate clinical and demographic factors associated with obstructive sleep apnea severity in adolescents. Design, Setting, and Participants: A retrospective case series of 224 children (53% male), ages 12 to 17 years who underwent polysomnography from January 1, 2013, to June 4, 2015...
February 23, 2017: JAMA Otolaryngology—Head & Neck Surgery
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