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https://www.readbyqxmd.com/read/28820754/sleep-apps-what-role-do-they-play-in-clinical-medicine
#1
Christopher P Lorenz, Adrian J Williams
PURPOSE OF REVIEW: Today's smartphones boast more computing power than the Apollo Guidance Computer. Given the ubiquity and popularity of smartphones, are we already carrying around miniaturized sleep labs in our pockets? RECENT FINDINGS: There is still a lack of validation studies for consumer sleep technologies in general and apps for monitoring sleep in particular. To overcome this gap, multidisciplinary teams are needed that focus on feasibility work at the intersection of software engineering, data science and clinical sleep medicine...
August 17, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28819593/an-isolated-pure-dislocation-of-fifth-carpometacarpal-joint-case-report-and-review-of-literature
#2
Rashid Anjum, Amit Roy, Kamran Farooque, Vijay Sharma
INTRODUCTION: Isolated pure dislocation of the fifth carpometacarpal (CMC) joint is a very rare injury and classified depending on displacement of the metacarpal base. This rare injury is often difficult to recognize and is liable to be overlooked. The purpose of this case report is to present a patient with an isolated dislocation of the fifth CMC joint that was satisfactorily treated with closed reduction and ulnar gutter pop slab. CASE REPORT: A 21-year-old male presented with severe pain on the right carpus following a fall with injury to right hand...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28818108/association-of-parents-and-children-s-physical-activity-and-sedentary-time-in-year-4-8-9-and-change-between-year-1-5-6-and-year-4-a-longitudinal-study
#3
Russell Jago, Emma Solomon-Moore, Corrie Macdonald-Wallis, Janice L Thompson, Deborah A Lawlor, Simon J Sebire
BACKGROUND: Parents could be important influences on child physical activity and parents are often encouraged to be more active with their child. This paper examined the association between parent and child physical activity and sedentary time in a UK cohort of children assessed when the children were in Year 1 (5-6 years old) and in Year 4 (8-9 years old). METHODS: One thousand two hundred twenty three children and parents provided data in Year 4 and of these 685 participated in Year 1...
August 17, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28812280/effect-of-missing-inter-beat-interval-data-on-heart-rate-variability-analysis-using-wrist-worn-wearables
#4
Hyun Jae Baek, JaeWook Shin
Most of the wrist-worn devices on the market provide a continuous heart rate measurement function using photoplethysmography, but have not yet provided a function to measure the continuous heart rate variability (HRV) using beat-to-beat pulse interval. The reason for such is the difficulty of measuring a continuous pulse interval during movement using a wearable device because of the nature of photoplethysmography, which is susceptible to motion noise. This study investigated the effect of missing heart beat interval data on the HRV analysis in cases where pulse interval cannot be measured because of movement noise...
August 15, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28809741/hepatitis-c-virus-infection-outcomes-among-immigrants-to-canada-a-retrospective-cohort-analysis
#5
Curtis L Cooper, Kednapa Thavorn, Ecaterina Damian, Daniel J Corsi
INTRODUCTION AND AIM: HCV-infected immigrants contribute to the total prevalence in Canada and other developed nations. Little is known about engagement in care, access to service, and treatment outcomes in recipients of Direct Acting Antiviral (DAA) HCV therapies among immigrants living with HCV. MATERIAL AND METHODS: HCV patients assessed at The Ottawa Hospital Viral Hepatitis Clinic between 2000-2016 were identified. Immigration history, race, socioeconomic status, HCV work-up, treatment and outcome data were evaluated...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28809684/combination-of-sharing-matrix-and-image-encryption-for-lossless-k-n-secret-image-sharing
#6
Long Bao, Shuang Yi, Yicong Zhou
This paper first introduces a (k, n)-sharing matrix S(k,n) and its generation algorithm. Mathematical analysis is provided to show its potential for secret image sharing. Combining sharing matrix with image encryption, we further propose a lossless (k, n)-secret image sharing scheme (SMIE-SIS). The chaotic image encryption is extremely sensitive to ciphertext. Little change in the ciphertext will lead to failure of noise-like decrypted results even with right key. Thus, even though sharing matrix will recover part of ciphertext information when less than k secret shares are combined, its missing information will result in a wrong key and a noise-like decryption result, keeping the secret from leakage...
August 10, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28806925/genomic-data-illuminates-demography-genetic-structure-and-selection-of-a-popular-dog-breed
#7
Pamela Wiener, Enrique Sánchez-Molano, Dylan N Clements, John A Woolliams, Marie J Haskell, Sarah C Blott
BACKGROUND: Genomic methods have proved to be important tools in the analysis of genetic diversity across the range of species and can be used to reveal processes underlying both short- and long-term evolutionary change. This study applied genomic methods to investigate population structure and inbreeding in a common UK dog breed, the Labrador Retriever. RESULTS: We found substantial within-breed genetic differentiation, which was associated with the role of the dog (i...
August 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28793312/delays-in-hiv-diagnosis-and-associated-factors-among-patients-presenting-with-advanced-disease-at-a-tertiary-care-hospital-in-beijing-china
#8
Jing Xie, Evelyn Hsieh, Meng-Qing Sun, Huan-Ling Wang, Wei Lv, Hong-Wei Fan, Tai-Sheng Li
Delayed diagnosis of HIV infection is associated with advanced immunosuppression and increased risk of onward transmission. Little data exists regarding factors associated with diagnostic delays among patients presenting with advanced HIV disease in China. Medical records of patients with HIV/AIDS hospitalized at a 2000-bed tertiary hospital in Beijing, China between 1997 and 2012 were retrospectively reviewed. Demographic and clinical data of patients newly diagnosed with HIV at the hospital were abstracted...
2017: PloS One
https://www.readbyqxmd.com/read/28780940/diagnosis-and-management-of-anaphylaxis-in-precision-medicine
#9
REVIEW
Mariana Castells
Anaphylaxis is the most severe and frightening of the allergic reactions, placing patients at high risk and demanding prompt recognition and immediate management by health care providers. Yet because its symptoms imitate those of other diseases, such as asthma and urticaria, current data suggest that its diagnosis is often missed, with underuse of tryptase measurement; its treatment is delayed, with little use of epinephrine; and its underlying cause or causes are poorly investigated. Deaths from anaphylaxis are difficult to investigate because of miscoding...
August 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28768606/the-potential-of-mobile-apps-for-improving-asthma-self-management-a-review-of-publicly-available-and-well-adopted-asthma-apps
#10
Peter Tinschert, Robert Jakob, Filipe Barata, Jan-Niklas Kramer, Tobias Kowatsch
BACKGROUND: Effective disease self-management lowers asthma's burden of disease for both individual patients and health care systems. In principle, mobile health (mHealth) apps could enable effective asthma self-management interventions that improve a patient's quality of life while simultaneously reducing the overall treatment costs for health care systems. However, prior reviews in this field have found that mHealth apps for asthma lack clinical evaluation and are often not based on medical guidelines...
August 2, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28764139/atlantooccipital-fusion-prevalence-and-its-developmental-and-clinical-correlation
#11
D K Sharma, Deepak Sharma, Vandana Sharma
INTRODUCTION: Atlantooccipital fusion or occipitalization of atlas or assimilation of atlas is a rare or uncommon abnormality recorded in anatomical, morphological and radiological studies. It is usually associated with reduction in dimensions of foramen magnum leading to acute or chronic neurovascular compression and clinical manifestations of varying severity. Though, atlantooccipital fusion is rare but it is important and significant for the physicians and surgeons for their diagnostic and therapeutic approach...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28758189/task-oriented-interventions-for-children-with-developmental-co-ordination-disorder
#12
REVIEW
Motohide Miyahara, Susan L Hillier, Liz Pridham, Shinichi Nakagawa
BACKGROUND: Developmental co-ordination disorder (DCD) is a common childhood disorder, which can persist into adolescence and adulthood. Children with DCD have difficulties in performing the essential motor tasks required for self-care, academic, social and recreational activities. OBJECTIVES: To assess the effectiveness of task-oriented interventions on movement performance, psychosocial functions, activity, and participation for children with DCD and to examine differential intervention effects as a factor of age, sex, severity of DCD, intervention intensity, and type of intervention...
July 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28755837/missed-opportunities-for-catch-up-human-papillomavirus-vaccination-among-university-undergraduates-identifying-health-decision-making-behaviors-and-uptake-barriers
#13
Kathleen R Ragan, Robert A Bednarczyk, Scott M Butler, Saad B Omer
BACKGROUND: Suboptimal adolescent human papillomavirus (HPV) vaccine rates in the US highlight the need for catch-up vaccination. When teenagers enter college, there may be a shift in healthcare decision-making from parents and guardians to the students themselves. Little is known about factors influencing college students' healthcare decision-making processes. STUDY DESIGN: We evaluated HPV vaccine decision-making among 18-to-26-year-old college students through a self-administered, anonymous, cross-sectional survey...
July 26, 2017: Vaccine
https://www.readbyqxmd.com/read/28754989/efficiency-of-ddrad-target-enriched-sequencing-across-spiny-rock-lobster-species-palinuridae-jasus
#14
Carla A Souza, Nicholas Murphy, Cecilia Villacorta-Rath, Laura N Woodings, Irina Ilyushkina, Cristian E Hernandez, Bridget S Green, James J Bell, Jan M Strugnell
Double digest restriction site-associated DNA sequencing (ddRADseq) and target capture sequencing methods are used to explore population and phylogenetic questions in non-model organisms. ddRADseq offers a simple and reliable protocol for population genomic studies, however it can result in a large amount of missing data due to allelic dropout. Target capture sequencing offers an opportunity to increase sequencing coverage with little missing data and consistent orthologous loci across samples, although this approach has generally been applied to conserved markers for deeper evolutionary questions...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747224/regions-of-common-inter-individual-dna-methylation-differences-in-human-monocytes-genetic-basis-and-potential-function
#15
Christopher Schröder, Elsa Leitão, Stefan Wallner, Gerd Schmitz, Ludger Klein-Hitpass, Anupam Sinha, Karl-Heinz Jöckel, Stefanie Heilmann-Heimbach, Per Hoffmann, Markus M Nöthen, Michael Steffens, Peter Ebert, Sven Rahmann, Bernhard Horsthemke
BACKGROUND: There is increasing evidence for inter-individual methylation differences at CpG dinucleotides in the human genome, but the regional extent and function of these differences have not yet been studied in detail. For identifying regions of common methylation differences, we used whole genome bisulfite sequencing data of monocytes from five donors and a novel bioinformatic strategy. RESULTS: We identified 157 differentially methylated regions (DMRs) with four or more CpGs, almost none of which has been described before...
July 26, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28740616/unlocking-the-potential-of-established-products-toward-new-incentives-rewarding-innovation-in-europe
#16
Gabrielle Nayroles, Sandrine Frybourg, Sylvie Gabriel, Åsa Kornfeld, Fernando Antoñanzas-Villar, Jaime Espín, Claudio Jommi, Nello Martini, Gérard de Pouvourville, Keith Tolley, Jürgen Wasem, Mondher Toumi
Background: Many established products (EPs - marketed for eight years or more) are widely used off-label despite little evidence on benefit-risk ratio. This exposes patients to risks related to safety and lack of efficacy, and healthcare providers to liability. Introducing new indications for EPs may represent a high societal value; however, manufacturers rarely invest in R&D for EPs. The objective of this research was to describe incentives and disincentives for developing new indications for EPs in Europe and to investigate consequences of current policies...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/28732834/patient-perceived-acceptability-and-behaviour-change-benefits-of-inhaler-reminders-and-adherence-feedback-a-qualitative-study
#17
Juliet M Foster, Helen K Reddel, Tim Usherwood, Susan M Sawyer, Lorraine Smith
INTRODUCTION: Little is known about patients' perceptions of electronic inhaler reminders, which have emerged in recent years as adherence promotion aids. This study explored asthma patients' attitudes toward the acceptability and utility of inhaler reminders. METHODS: Participants from a 6-month cluster randomized controlled trial who received reminders for missed doses via SmartTrack adherence monitors (Adherium Ltd) were interviewed to explore their perceptions; interviews were audio-recorded, transcribed and analysed thematically...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28725422/lesson-learnt-from-a-migrated-drain-a-case-report
#18
Veerabhadra Radhakrishna, Sharad M Tanga
INTRODUCTION: Though surgical drainage is used as a safety measure, it's not without complications. Migration of various drains has been described, but very little literature refers to the migration of peritoneal drain. PRESENTATION OF CASE: A 55-year male underwent anterior Gastro-Jejunostomy for inoperable metastatic carcinoma of the Gastric Pylorus. We found the peritoneal drain missing on the third post-operative day. On further evaluation, we found it to have migrated into the peritoneal cavity...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28723287/advanced-renal-cell-carcinoma-role-of-the-radiologist-in-the-era-of-precision-medicine
#19
REVIEW
Atul B Shinagare, Katherine M Krajewski, Marta Braschi-Amirfarzan, Nikhil H Ramaiya
For the past decade, advanced renal cell carcinoma (RCC) has been at the forefront of oncologic innovation. Our rapidly evolving understanding of the molecular and genetic basis of RCC has revolutionized the management of advanced RCC; 10 novel molecular targeted agents and immune checkpoint inhibitor have received U.S. Food and Drug Administration approval for treatment of advanced RCC in a little over a decade. Amid this progress, imaging has assumed a central role in metastatic surveillance and follow-up of advanced RCC...
August 2017: Radiology
https://www.readbyqxmd.com/read/28717880/environmental-exposure-does-not-explain-putative-maladaptation-in-road-adjacent-populations
#20
Steven P Brady
While the ecological consequences of roads are well described, little is known of their role as agents of natural selection, which can shape adaptive and maladaptive responses in populations influenced by roads. This knowledge gap persists despite a growing appreciation for the influence of evolution in human-altered environments. There, insights indicate that natural selection typically results in local adaptation. Thus, populations influenced by road-induced selection should evolve fitness advantages in their local environment...
July 17, 2017: Oecologia
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