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https://www.readbyqxmd.com/read/29455865/kin-networks-and-mobility-in-the-transition-to-adulthood
#1
Janel E Benson, Anastassia Bougakova
Family support is critical for launching youth into successful adult lives. Although studies have documented the association between family support and success in the transition to young adulthood, existing work focuses primarily on parental support, giving little attention to extended kin. This narrow definition of family may miss critical exchanges of support, especially among low-income families. Drawing on panel survey data (n=450) and in-depth interviews (n=52) with young women from the Philadelphia Educational Longitudinal Study, this study expands our understanding of family support in the transition to adulthood by examining young adults' kin networks and the types of support and resources embedded within these networks...
2018: Advances in Child Development and Behavior
https://www.readbyqxmd.com/read/29452734/calcar-screw-position-in-proximal-humerus-fracture-fixation-don-t-miss-high
#2
Samir Mehta, Matthew Chin, Jennifer Sanville, Surena Namdari, Michael W Hast
INTRODUCTION: In locked plate fixation of proximal humerus fractures, the calcar is an important anchor point for screws providing much-needed medial column support. Most locking plate implants utilize a fixed-trajectory locking screw to achieve this goal. Consequently, adjustments of plate location to account for patient-specific anatomy may result in a screw position outside of the calcar. To date, little is known about the consequences of "missing" the calcar during plate positioning...
February 11, 2018: Injury
https://www.readbyqxmd.com/read/29452587/timing-of-abortion-among-adolescent-and-young-women-presenting-for-post-abortion-care-in-kenya-a-cross-sectional-analysis-of-nationally-representative-data
#3
Boniface A Ushie, Chimaraoke O Izugbara, Michael M Mutua, Caroline W Kabiru
BACKGROUND: Complications of unsafe abortion are a leading cause of maternal mortality in sub-Saharan Africa. Adolescents and young women are disproportionately represented among those at risk of these complications. Currently, we know little about the factors associated with young women's timing of abortion. This study examined the timing of abortion as well as factors influencing it among adolescents and young women aged 12-24 years who sought post-abortion care (PAC) in health facilities in Kenya...
February 17, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29445313/little-composite-dark-matter
#4
Reuven Balkin, Gilad Perez, Andreas Weiler
We examine the dark matter phenomenology of a composite electroweak singlet state. This singlet belongs to the Goldstone sector of a well-motivated extension of the Littlest Higgs with T -parity. A viable parameter space, consistent with the observed dark matter relic abundance as well as with the various collider, electroweak precision and dark matter direct detection experimental constraints is found for this scenario. T -parity implies a rich LHC phenomenology, which forms an interesting interplay between conventional natural SUSY type of signals involving third generation quarks and missing energy, from stop-like particle production and decay, and composite Higgs type of signals involving third generation quarks associated with Higgs and electroweak gauge boson, from vector-like top-partners production and decay...
2018: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/29439682/the-factors-affecting-household-transmission-dynamics-and-community-compliance-with-ebola-control-measures-a-mixed-methods-study-in-a-rural-village-in-sierra-leone
#5
Grazia Caleo, Jennifer Duncombe, Freya Jephcott, Kamalini Lokuge, Clair Mills, Evita Looijen, Fivi Theoharaki, Ronald Kremer, Karline Kleijer, James Squire, Manjo Lamin, Beverley Stringer, Helen A Weiss, Daniel Culli, Gian Luca Di Tanna, Jane Greig
BACKGROUND: Little is understood of Ebola virus disease (EVD) transmission dynamics and community compliance with control measures over time. Understanding these interactions is essential if interventions are to be effective in future outbreaks. We conducted a mixed-methods study to explore these factors in a rural village that experienced sustained EVD transmission in Kailahun District, Sierra Leone. METHODS: We reconstructed transmission dynamics using a cross-sectional survey conducted in April 2015, and cross-referenced our results with surveillance, burial, and Ebola Management Centre (EMC) data...
February 13, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29438597/personally-tailored-activities-for-improving-psychosocial-outcomes-for-people-with-dementia-in-long-term-care
#6
REVIEW
Ralph Möhler, Anna Renom, Helena Renom, Gabriele Meyer
BACKGROUND: People with dementia who are being cared for in long-term care settings are often not engaged in meaningful activities. Offering them activities which are tailored to their individual interests and preferences might improve their quality of life and reduce challenging behaviour. OBJECTIVES: ∙ To assess the effects of personally tailored activities on psychosocial outcomes for people with dementia living in long-term care facilities.∙ To describe the components of the interventions...
February 13, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29431653/regulation-of-synapse-development-by-vgat-deletion-from-erbb4-positive-interneurons
#7
Thiri W Lin, Zhibing Tan, Arnab Barik, Dong-Min Yin, Egil Brudvik, Hongsheng Wang, Wen-Cheng Xiong, Lin Mei
GABA signaling has been implicated in neural development; however, in vivo genetic evidence is missing because mutant mice lacking GABA activity die prematurely. Here, we studied synapse development by ablating vesicular GABA transporter Vgat in in ErbB4-positive (ErbB4+) interneurons. We show that inhibitory axo-somatic synapses onto pyramidal neurons vary from one cortical layer to another; however, inhibitory synapses on axon initial segments (AISs) were similar across layers. On the other hand, PV-positive (PV+)/ErbB4+ interneurons and PV-only interneurons receive a higher number of inhibitory synapses from PV+ErbB4+ interneurons, compared with ErbB4-only interneurons...
February 5, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29431135/challenges-of-diagnosis-and-management-of-giant-cell-arteritis-in-general-practice-a-multimethods-study
#8
Toby Helliwell, Sara Muller, Samantha L Hider, James A Prior, Jane C Richardson, Christian D Mallen
BACKGROUND: In the UK, general practitioners (GPs) are usually the first medical contact for patients with suspected giant cell arteritis (GCA). While rare, it is critical not to miss, as delayed treatment can lead to significant complications including permanent visual loss. To date, little is known about the approach and challenges to diagnosis and management of GCA by GPs. OBJECTIVE: To investigate the diagnosis and management of patients with suspected GCA in UK general practice...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29430883/models-to-predict-length-of-stay-in-the-intensive-care-unit-after-coronary-artery-bypass-grafting-a-systematic-review
#9
Alireza Atashi, Ilona W Verburg, Hesam Karim, Mirmohammad Miri, Ameen Abu-Hanna, Evert de Jonge, Nicolette F de Keizer, Saeid Eslami
INTRODUCTION: ICU Length of stay (LoS) prediction models are used to compare different institutions and surgeons on their performance, and is useful as an efficiency indicator for quality control. There is little consensus about which prediction methods are most suitable to predict (ICU) length of stay. The aim of this study is to systematically review models for predicting ICU LoS after coronary artery bypass grafting and to assess the reporting and methodological quality of these models to apply them for benchmarking...
February 8, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29424787/major-depressive-disorder-longitudinal-analysis-of-impact-on-clinical-and-behavioural-outcomes-in-uganda
#10
Eugene Kinyanda, Jonathan Levin, Noeline Nakasujja, Harriet Birabwa, Juliet Nakku, Richard Mpango, Heiner Grosskurth, Soraya Seedat, Ricardo Araya, Maryam Shahmanesh, Vikram Patel
BACKGROUND: There is still wide variability in HIV disease course and other HIV related outcomes, attributable in part to psychosocial factors such as major depressive disorder (MDD), a subject that has received little attention in sub-Saharan Africa. METHODS: Using a longitudinal cohort of 1099 HIV positive antiretroviral therapy (ART) naïve persons, we investigated the impact of MDD on four HIV related negative outcome domains in Uganda. MDD was assessed using a Diagnostic Statistical Manual IV based tool...
February 7, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29420674/histomorphometric-study-of-new-bone-formation-comparing-defect-healing-with-three-bone-grafting-materials-the-effect-of-osteoporosis-on-graft-consolidation
#11
Qiao Zhang, Dai Jing, Yufeng Zhang, Richard J Miron
PURPOSE: Bone grafting materials are frequently utilized in oral surgery and periodontology to fill bone defects and augment lost or missing bone. The purpose of this study was to compare new bone formation in bone defects created in both normal and osteoporotic animals loaded with three types of bone grafts from different origins. MATERIALS AND METHODS: Forty-eight female Wistar rats were equally divided into control normal and ovariectomized animals. Bilateral 2...
February 8, 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29408905/splenic-macrophages-are-required-for-protective-innate-immunity-against-west-nile-virus
#12
Marianne A Bryan, Daniela Giordano, Kevin E Draves, Richard Green, Michael Gale, Edward A Clark
Although the spleen is a major site for West Nile virus (WNV) replication and spread, relatively little is known about which innate cells in the spleen replicate WNV, control viral dissemination, and/or prime innate and adaptive immune responses. Here we tested if splenic macrophages (MΦs) were necessary for control of WNV infection. We selectively depleted splenic MΦs, but not draining lymph node MΦs, by injecting mice intravenously with clodronate liposomes several days prior to infecting them with WNV...
2018: PloS One
https://www.readbyqxmd.com/read/29403567/random-forest-missing-data-algorithms
#13
Fei Tang, Hemant Ishwaran
Random forest (RF) missing data algorithms are an attractive approach for imputing missing data. They have the desirable properties of being able to handle mixed types of missing data, they are adaptive to interactions and nonlinearity, and they have the potential to scale to big data settings. Currently there are many different RF imputation algorithms, but relatively little guidance about their efficacy. Using a large, diverse collection of data sets, imputation performance of various RF algorithms was assessed under different missing data mechanisms...
December 2017: Statistical Analysis and Data Mining
https://www.readbyqxmd.com/read/29399436/current-state-of-follow-up-care-for-patients-with-hymenoptera-venom-anaphylaxis-in-southwest-germany-major-impact-of-early-information
#14
Manisha Manmohan, Sabine Müller, Michèle Myriam Rauber, Frank Koberne, H Reisch, Joachim Koster, Richard Böhm, Martin Messelken, Matthias Fischer, Thilo Jakob
Background: Up to 3.5% of the population experience anaphylactic reactions in response to Hymenoptera stings. Current guidelines are in place for the diagnostic workup and follow-up care of patients with Hymenoptera venom anaphylaxis (HVA). However, little is known about the degree of implementation of the recommendations and patient attitudes toward the recommendations in the general patient population. Methods: For the analysis of the follow-up care in real life, a retrospective questionnaire-based study was conducted in unselected patients who had received treatment from an emergency medical response team for HVA, as documented in records of three regional Medical Emergency Response Centers...
2018: Allergo Journal International
https://www.readbyqxmd.com/read/29396528/a-missing-link-in-the-estuarine-nitrogen-cycle-coupled-nitrification-denitrification-mediated-by-suspended-particulate-matter
#15
Weijing Zhu, Cheng Wang, Jaclyn Hill, Yangyang He, Bangyi Tao, Zhihua Mao, Weixiang Wu
In estuarine and coastal ecosystems, the majority of previous studies have considered coupled nitrification-denitrification (CND) processes to be exclusively sediment based, with little focus on suspended particulate matter (SPM) in the water column. Here, we present evidence of CND processes in the water column of Hangzhou Bay, one of the largest macrotidal embayments in the world. Spearman's correlation analysis showed that SPM was negatively correlated with nitrate (rho = -0.372, P = 0.018) and marker genes for nitrification and denitrification in the water column were detected by quantitative PCR analysis...
February 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29389838/too-little-too-late-hypotension-and-blood-transfusion-in-the-trauma-bay-are-independent-predictors-of-death-in-injured-children
#16
Christine M Leeper, Christine McKenna, Barbara A Gaines
BACKGROUND: Hypotension is a late finding in pediatric shock despite significant blood loss; consequently, recognition of hemodynamic compromise can be delayed. We sought to describe the impact of late stage shock in children, indicated by hypotension or trauma bay blood transfusion, and quantify the association with poor outcome. METHODS: Children age<18 from the Pennsylvania Trauma Outcome Study registry (2000-2013) were included. Primary outcome was mortality...
January 31, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29388687/interventions-for-weight-reduction-in-obesity-to-improve-survival-in-women-with-endometrial-cancer
#17
REVIEW
Sarah Kitson, Neil Ryan, Michelle L MacKintosh, Richard Edmondson, James Mn Duffy, Emma J Crosbie
BACKGROUND: Diagnoses of endometrial cancer are increasing secondary to the rising prevalence of obesity. Obesity plays an important role in promoting the development of endometrial cancer, by inducing a state of unopposed oestrogen excess, insulin resistance and inflammation. It also affects treatment, increasing the risk of surgical complications and the complexity of radiotherapy planning, and may additionally impact on subsequent survival. Weight-loss interventions have been associated with improvements in breast and colorectal cancer-specific survival as well as a reduction in the risk of cardiovascular disease, a frequent cause of death in endometrial cancer survivors...
February 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29359634/ebola-and-healthcare-worker-stigma
#18
Misse Wester, Johan Giesecke
AIMS: Exposure to infection is a risk for all healthcare workers. This risk acquires another dimension in an outbreak of highly contagious, lethal disease, such as the Ebola epidemic in West Africa in 2014. Healthcare workers are usually well and correctly informed about the risks from such diseases, but family, neighbours, friends, or colleagues may react strongly to the risk that staff might bring infection home from an epidemic overseas. Research around such stigmatization is scarce...
January 1, 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29357120/magnetic-resonance-perfusion-for-differentiating-low-grade-from-high-grade-gliomas-at-first-presentation
#19
REVIEW
Jill M Abrigo, Daniel M Fountain, James M Provenzale, Eric K Law, Joey Sw Kwong, Michael G Hart, Wilson Wai San Tam
BACKGROUND: Gliomas are the most common primary brain tumour. They are graded using the WHO classification system, with Grade II-IV astrocytomas, oligodendrogliomas and oligoastrocytomas. Low-grade gliomas (LGGs) are WHO Grade II infiltrative brain tumours that typically appear solid and non-enhancing on magnetic resonance imaging (MRI) scans. People with LGG often have little or no neurologic deficit, so may opt for a watch-and-wait-approach over surgical resection, radiotherapy or both, as surgery can result in early neurologic disability...
January 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29355907/e-learning-for-health-professionals
#20
REVIEW
Alberto Vaona, Rita Banzi, Koren H Kwag, Giulio Rigon, Danilo Cereda, Valentina Pecoraro, Irene Tramacere, Lorenzo Moja
BACKGROUND: The use of e-learning, defined as any educational intervention mediated electronically via the Internet, has steadily increased among health professionals worldwide. Several studies have attempted to measure the effects of e-learning in medical practice, which has often been associated with large positive effects when compared to no intervention and with small positive effects when compared with traditional learning (without access to e-learning). However, results are not conclusive...
January 21, 2018: Cochrane Database of Systematic Reviews
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