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https://www.readbyqxmd.com/read/29032707/safety-of-psychiatric-inpatients-at-the-veterans-health-administration
#1
Steven C Marcus, Richard C Hermann, Martin R Frankel, Sara W Cullen
OBJECTIVE: Although reducing adverse events and medical errors has become a central focus of the U.S. health care system over the past two decades both within and outside the Veterans Health Administration (VHA) hospital systems, patients treated in psychiatric units of acute care general hospitals have been excluded from major research in this field. METHODS: The study included a random sample of 40 psychiatric units from medical centers in the national VHA system...
October 16, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29032396/assessing-adherence-to-antihypertensive-therapy-in-primary-health-care-in-namibia-findings-and-implications
#2
M M Nashilongo, B Singu, F Kalemeera, M Mubita, E Naikaku, A Baker, A Ferrario, B Godman, L Achieng, D Kibuule
INTRODUCTION: Namibia has the highest burden and incidence of hypertension in sub-Sahara Africa. Though non-adherence to antihypertensive therapy is an important cardiovascular risk factor, little is known about potential ways to improve adherence in Namibia following universal access. The objective of this study is to validate the Hill-Bone compliance scale and determine the level and predictors of adherence to antihypertensive treatment in primary health care settings in sub-urban townships of Windhoek, Namibia...
October 14, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29029338/to-include-or-not-to-include-the-impact-of-gene-filtering-on-species-tree-estimation-methods
#3
Erin K Molloy, Tandy Warnow
With the increasing availability of whole genome data, many species trees are being constructed from hundreds to thousands of loci. Although concatenation analysis using maximum likelihood is a standard approach for estimating species trees, it does not account for gene tree heterogeneity, which can occur due to many biological processes, such as incomplete lineage sorting. Coalescent species tree estimation methods, many of which are statistically consistent in the presence of incomplete lineage sorting, include Bayesian methods that co-estimate the gene trees and the species tree, summary methods that compute the species tree by combining estimated gene trees, and site-based methods that infer the species tree from site patterns in the alignments of different loci...
September 15, 2017: Systematic Biology
https://www.readbyqxmd.com/read/29023703/use-of-multi-intake-temporal-dominance-of-sensations-tds-to-evaluate-the-influence-of-wine-on-cheese-perception
#4
Mara V Galmarini, Anne-Laure Loiseau, Doëtte Debreyer, Michel Visalli, Pascal Schlich
Even if wine and cheese have long been consumed together, there is little sensory evidence on how wine can influence the perception of cheese. In this work 4 cheeses were dynamically characterized in terms of dominant sensations without and with wine consumption in between intakes. The tasting protocol was based on multi-intake temporal dominance of sensations (TDS) coupled with hedonic rating. Frequent wine and cheese consumers (n = 31) evaluated 4 cheeses (Epoisses, Chaource, and 2 different Comté) over 3 consecutive bites...
October 12, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29023218/out-of-hospital-pediatric-patient-safety-events-results-of-the-csi-chart-review
#5
Garth Meckler, Matthew Hansen, William Lambert, Kerth O'Brien, Caitlin Dickinson, Kathryn Dickinson, Joshua Van Otterloo, Jeanne-Marie Guise
OBJECTIVE: Studies of adult hospital patients have identified medical errors as a significant cause of morbidity and mortality. Little is known about the frequency and nature of pediatric patient safety events in the out-of-hospital setting. We sought to quantify pediatric patient safety events in EMS and identify patient, call, and care characteristics associated with potentially severe events. METHODS: As part of the Children's Safety Initiative -EMS, expert panels independently reviewed charts of pediatric critical ambulance transports in a metropolitan area over a three-year period...
October 12, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29018478/ultrafast-comparison-of-personal-genomes-via-precomputed-genome-fingerprints
#6
Gustavo Glusman, Denise E Mauldin, Leroy E Hood, Max Robinson
We present an ultrafast method for comparing personal genomes. We transform the standard genome representation (lists of variants relative to a reference) into "genome fingerprints" via locality sensitive hashing. The resulting genome fingerprints can be meaningfully compared even when the input data were obtained using different sequencing technologies, processed using different pipelines, represented in different data formats and relative to different reference versions. Furthermore, genome fingerprints are robust to up to 30% missing data...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29017764/dna-methylation-and-antipsychotic-treatment-mechanisms-in-schizophrenia-progress-and-future-directions
#7
REVIEW
Ellen S Ovenden, Nathaniel W McGregor, Robin A Emsley, Louise Warnich
Antipsychotic response in schizophrenia is a complex, multifactorial trait influenced by pharmacogenetic factors. With genetic studies thus far providing little biological insight or clinical utility, the field of pharmacoepigenomics has emerged to tackle the so-called "missing heritability" of drug response in disease. Research on psychiatric disorders has only recently started to assess the link between epigenetic alterations and treatment outcomes. DNA methylation, the best characterised epigenetic mechanism to date, is discussed here in the context of schizophrenia and antipsychotic treatment outcomes...
October 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28992601/tooth-damage-in-captive-orcas-orcinus-orca
#8
John Jett, Ingrid N Visser, Jeffrey Ventre, Jordan Waltz, Carolina Loch
OBJECTIVES: Tooth damage as a result of oral stereotypies is evident in captive orca, yet little research on the topic exists. This study examines the associations between dental pathology, sex, facility, duration of captivity and other factors in captive orca. DESIGN: We evaluated mandibular and maxillary teeth from dental images of 29 captive orca owned by a US-based theme park. Each tooth was scored for coronal wear, wear at or below gum line and bore holes. Fractured and missing teeth were also noted...
September 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28990686/hierarchical-imputation-of-systematically-and-sporadically-missing-data-an-approximate-bayesian-approach-using-chained-equations
#9
Shahab Jolani
In health and medical sciences, multiple imputation (MI) is now becoming popular to obtain valid inferences in the presence of missing data. However, MI of clustered data such as multicenter studies and individual participant data meta-analysis requires advanced imputation routines that preserve the hierarchical structure of data. In clustered data, a specific challenge is the presence of systematically missing data, when a variable is completely missing in some clusters, and sporadically missing data, when it is partly missing in some clusters...
October 9, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28982706/neural-signature-of-value-based-sensorimotor-prioritization-in-humans
#10
Annabelle Blangero, Simon P Kelly
In situations where impending sensory events demand fast action choices, we must be ready to prioritize higher-value courses of action in order to avoid missed opportunities. When such a situation first presents itself, stimulus-action contingencies and their relative value must be encoded in order to establish a value-biased state of preparation for an impending sensorimotor decision. Here we sought to identify neurophysiological signatures of such processes in the human brain (both female and male). We devised a task requiring fast action choices based on the discrimination of a simple visual cue, in which the differently-valued sensory alternatives were presented 750-800 msec beforehand as peripheral "targets" that specified the stimulus-action mapping for the upcoming decision...
October 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28982219/mechanical-ventilation-for-amyotrophic-lateral-sclerosis-motor-neuron-disease
#11
REVIEW
Aleksandar Radunovic, Djillali Annane, Muhammad K Rafiq, Ruth Brassington, Naveed Mustfa
BACKGROUND: Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is a fatal neurodegenerative disease. Neuromuscular respiratory failure is the most common cause of death, which usually occurs within two to five years of the disease onset. Supporting respiratory function with mechanical ventilation may improve survival and quality of life. This is the second update of a review first published in 2009. OBJECTIVES: To assess the effects of mechanical ventilation (tracheostomy-assisted ventilation and non-invasive ventilation (NIV)) on survival, functional measures of disease progression, and quality of life in ALS, and to evaluate adverse events related to the intervention...
October 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28970747/an-approach-to-measuring-integrated-care-within-a-maternity-care-system-experiences-from-the-maternity-care-network-study-and-the-dutch-birth-centre-study
#12
Inge C Boesveld, Pim P Valentijn, Marit Hitzert, Marieke A A Hermus, Arie Franx, Raymond G de Vries, Therese A Wiegers, Marc A Bruijnzeels
INTRODUCTION: Integrated care is considered to be a means to reduce costs, improve the quality of care and generate better patient outcomes. At present, little is known about integrated care in maternity care systems. We developed questionnaires to examine integrated care in two different settings, using the taxonomy of the Rainbow Model of Integrated Care. The aim of this study was to explore the validity of these questionnaires. METHODS: We used data collected between 2013 and 2015 from two studies: the Maternity Care Network Study (634 respondents) and the Dutch Birth Centre Study (56 respondents)...
June 20, 2017: International Journal of Integrated Care
https://www.readbyqxmd.com/read/28965183/understanding-perspectives-of-african-american-medicaid-insured-women-on-the-process-of-perinatal-care-an-opportunity-for-systems-improvement
#13
Lee Anne Roman, Jennifer E Raffo, Katherine Dertz, Bonita Agee, Denise Evans, Katherine Penninga, Tiffany Pierce, Belinda Cunningham, Peggy VanderMeulen
Objectives To address disparities in adverse birth outcomes, communities are challenged to improve the quality of health services and foster systems integration. The purpose of this study was to explore the perspectives of Medicaid-insured women about their experiences of perinatal care (PNC) across a continuum of clinical and community-based services. Methods Three focus groups (N = 21) were conducted and thematic analysis methods were used to identify basic and global themes about experiences of care...
September 30, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28959699/distal-fibula-fractures-in-national-football-league-athletes
#14
Brian C Werner, Christina Mack, Kristina Franke, Ronnie P Barnes, Russell F Warren, Scott A Rodeo
BACKGROUND: Despite the frequency of distal fibula fractures in elite athletes and the significant potential impact on the athletes' season and future careers, little data exist characterizing the epidemiology of these injuries or, more importantly, return to competition. PURPOSE: To (1) evaluate the incidence of acute distal fibula fractures in National Football League (NFL) athletes, including isolated distal fibula and combined ankle fracture patterns; (2) analyze distal fibula fracture rates in NFL athletes by position, type of play, and contact type; (3) determine the rates of distal fibula fracture surgery in NFL athletes; and (4) report the days missed due to distal fibula fractures in NFL athletes...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28952889/differences-between-incarcerated-and-non-incarcerated-patients-who-die-in-community-hospitals-highlight-the-need-for-palliative-care-services-for-seriously-ill-prisoners-in-correctional-facilities-and-in-community-hospitals-a-cross-sectional-study
#15
Alex Rothman, Shannon McConville, Renee Hsia, Lia Metzger, Cyrus Ahalt, Brie A Williams
BACKGROUND: Incarcerated populations worldwide are aging dramatically; in the United States, prisoner mortality rates have reached an all-time high. Little is known about the incarcerated patients who die in community hospitals. AIM: Compare incarcerated and non-incarcerated hospital decedents in California. DESIGN: Cross-sectional study. SETTING/PARTICIPANTS: All state hospital decedents ( N = 370,831) from 2009 to 2013, decedent age over time examined with additional data (2001-2013)...
September 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28950835/determinants-of-uptake-of-hepatitis-b-testing-and-healthcare-access-by-migrant-chinese-in-the-england-a-qualitative-study
#16
Andrew Chee Keng Lee, Alicia Vedio, Eva Zhi Hong Liu, Jason Horsley, Amrita Jesurasa, Sarah Salway
BACKGROUND: Global migration from hepatitis B endemic countries poses a significant public health challenge in receiving low-prevalence countries. In the UK, Chinese migrants are a high risk group for hepatitis B. However, they are an underserved population that infrequently accesses healthcare. This study sought to increase understanding of the determinants of hepatitis B testing and healthcare access among migrants of Chinese ethnicity living in England. METHODS: We sought to obtain and integrate insights from different key stakeholders in the system...
September 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28947697/-dental-implant-treatment-in-patients-receiving-anti-resorptive-agents
#17
Shinichiro Kuroshima
Dental implant treatment is one of the most reliable therapeutic options for replacing missing teeth. In 2003, it was demonstrated that osteonecrosis of the jaw(ONJ)occurred in patients taking bisphosphonates(BRONJ). Recently, ONJ has also been demonstrated to occur in patients taking anti-receptor activator of nuclear factor-kappaB ligand antibody(denosumab:DRONJ). However, the precise mechanisms of ONJ remain unclear and definitive treatment strategies for ONJ have not been developed. There has been little information regarding the relationship between ONJ and dental implant treatment...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28938735/the-age-of-fathers-in-the-usa-is-rising-an-analysis-of-168-867-480-births-from-1972-to-2015
#18
Yash S Khandwala, Chiyuan A Zhang, Ying Lu, Michael L Eisenberg
STUDY QUESTION: How has the mean paternal age in the USA changed over the past 4 decades? SUMMARY ANSWER: The age at which men are fathering children in the USA has been increasing over time, although it varies by race, geographic region and paternal education level. WHAT IS KNOWN ALREADY: While the rise in mean maternal age and its implications for fertility, birth outcomes and public health have been well documented, little is known about paternal characteristics of births within the USA...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28936422/forgotten-excluded-or-included-students-with-disabilities-a-case-study-at-the-university-of-mauritius
#19
Sameerchand Pudaruth, Rajendra P Gunputh, Upasana G Singh
BACKGROUND: Students with disabilities in the tertiary education sector are more than a just a phenomenon, they are a reality. In general, little attention is devoted to their needs despite the fact that they need more care and attention. OBJECTIVES: This paper, through a case study at the University of Mauritius, sought to answer some pertinent questions regarding students with disabilities. Does the University of Mauritius have sufficient facilities to support these students? Are students aware of existing facilities? What additional structures need to be put in place so that students with any form of disability are neither victimised, nor their education undermined? Are there any local laws about students with disabilities in higher education? METHOD: To answer these questions and others, an online questionnaire was sent to 500 students and the responses were then analysed and discussed...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28935163/optimising-the-diagnosis-of-prostate-cancer-in-the-era-of-multiparametric-magnetic-resonance-imaging-a-cost-effectiveness-analysis-based-on-the-prostate-mr-imaging-study-promis
#20
Rita Faria, Marta O Soares, Eldon Spackman, Hashim U Ahmed, Louise C Brown, Richard Kaplan, Mark Emberton, Mark J Sculpher
BACKGROUND: The current recommendation of using transrectal ultrasound-guided biopsy (TRUSB) to diagnose prostate cancer misses clinically significant (CS) cancers. More sensitive biopsies (eg, template prostate mapping biopsy [TPMB]) are too resource intensive for routine use, and there is little evidence on multiparametric magnetic resonance imaging (MPMRI). OBJECTIVE: To identify the most effective and cost-effective way of using these tests to detect CS prostate cancer...
September 18, 2017: European Urology
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