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https://www.readbyqxmd.com/read/29234822/-acute-vestibular-syndrome-clinical-examination-outperforms-mri-in-the-detection-of-central-lesions
#1
REVIEW
F Thömke
A significant number of patients who seek medical treatment in an emergency department because of vertigo or dizziness, suffer from acute vestibular syndrome. This is characterized by sustained vertigo, horizontal or horizontal rotatory jerk nystagmus, and unsteady stance and gait. In the acute situation it is crucial to differentiate patients with a peripheral vestibular disorder from those with a central disease. A number of recent studies have shown that a structured clinical examination enables a reliable differential diagnosis of central or peripheral disorders...
December 12, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/29223597/missed-opportunities-for-hpv-immunization-among-young-adult-women
#2
Carlos R Oliveira, Robert M Rock, Eugene D Shapiro, Xiao Xu, Lisbet Lundsberg, Liye B Zhang, Aileen Gariepy, Jessica L Illuzzi, Sangini S Sheth
BACKGROUND: Despite the availability of a safe and efficacious vaccine against HPV, uptake of the vaccine in the United States is low. Missed clinical opportunities to recommend and to administer HPV vaccine are considered one of the most important reasons for its low uptake in adolescents, however, little is known about the frequency or characteristics of missed opportunities in the young adult (18-26 years of age) population. OBJECTIVES: To assess both the rates of and the factors associated with missed opportunities for HPV immunization among young adult women who attended an urban obstetrics and gynecology clinic...
December 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29219886/impact-of-clavicle-fractures-on-return-to-play-and-performance-ratings-in-nfl-athletes
#3
Darshan Vora, Matthew Baker, Rajeev Pandarinath
OBJECTIVE: Clavicle fractures in the National Football League (NFL) have gained significant attention because of their impact on high profile athletes; however, little has been published on the overall impact of these injuries. This study sought to determine the time to return to play and quantitative impact on athletic performance after clavicle fractures in NFL athletes. DESIGN: Retrospective Cohort Study; Level of evidence, 3. SETTING: Retrospective cohort study of NFL athletes based on published injury reports and player statistics...
December 1, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29216895/-we-do-not-know-a-qualitative-study-exploring-boys-perceptions-of-menstruation-in-india
#4
Linda Mason, Muthusamy Sivakami, Harshad Thakur, Narendra Kakade, Ashley Beauman, Kelly T Alexander, Anna Maria van Eijke, Kayla F Laserson, Mamita B Thakkar, Penelope A Phillips-Howard
BACKGROUND: In low-middle income countries and other areas of poverty, menstrual hygiene management (MHM) can be problematic for women and girls. Issues include lack of knowledge about menstruation and MHM, and stigma around menstruation, also access to affordable and absorbent materials; privacy to change; adequate washing, cleaning and drying facilities; as well as appropriate and accessible disposal facilities. In order to effect change and tackle these issues, particularly in patriarchal societies, males may need to become advocates for MHM alongside women...
December 8, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29215711/triage-tools-for-detecting-cervical-spine-injury-in-pediatric-trauma-patients
#5
REVIEW
Annelie Slaar, M M Fockens, Junfeng Wang, Mario Maas, David J Wilson, J Carel Goslings, Niels Wl Schep, Rick R van Rijn
BACKGROUND: Pediatric cervical spine injury (CSI) after blunt trauma is rare. Nonetheless, missing these injuries can have severe consequences. To prevent the overuse of radiographic imaging, two clinical decision tools have been developed: The National Emergency X-Radiography Utilization Study (NEXUS) criteria and the Canadian C-spine Rule (CCR). Both tools are proven to be accurate in deciding whether or not diagnostic imaging is needed in adults presenting for blunt trauma screening at the emergency department...
December 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29214975/home-based-health-promotion-for-older-people-with-mild-frailty-the-homehealth-intervention-development-and-feasibility-rct
#6
Kate Walters, Rachael Frost, Kalpa Kharicha, Christina Avgerinou, Benjamin Gardner, Federico Ricciardi, Rachael Hunter, Ann Liljas, Jill Manthorpe, Vari Drennan, John Wood, Claire Goodman, Ana Jovicic, Steve Iliffe
BACKGROUND: Mild frailty or pre-frailty is common and yet is potentially reversible. Preventing progression to worsening frailty may benefit individuals and lower health/social care costs. However, we know little about effective approaches to preventing frailty progression. OBJECTIVES: (1) To develop an evidence- and theory-based home-based health promotion intervention for older people with mild frailty. (2) To assess feasibility, costs and acceptability of (i) the intervention and (ii) a full-scale clinical effectiveness and cost-effectiveness randomised controlled trial (RCT)...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29212630/clarifying-the-concept-of-adherence-to-ehealth-technology-systematic-review-on-when-usage-becomes-adherence
#7
REVIEW
Floor Sieverink, Saskia M Kelders, Julia Ewc van Gemert-Pijnen
BACKGROUND: In electronic health (eHealth) evaluations, there is increasing attention for studying the actual usage of a technology in relation to the outcomes found, often by studying the adherence to the technology. On the basis of the definition of adherence, we suggest that the following three elements are necessary to determine adherence to eHealth technology: (1) the ability to measure the usage behavior of individuals; (2) an operationalization of intended use; and (3) an empirical, theoretical, or rational justification of the intended use...
December 6, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29212394/management-of-dental-caries-among-children-a-look-at-the-cost-effectiveness
#8
Nathalia Miranda Ladewig, Lucila Basto Camargo, Tamara Kerber Tedesco, Isabela Floriano, Thais Gimenez, José Carlos P Imparato, Fausto Medeiros Mendes, Mariana Minatel Braga, Daniela Prócida Raggio
Dental caries is the most prevalent non-communicative disease worldwide. Although the etiological factors are well known for years, reducing the number of decayed and missing teeth in children still remains as a barrier. Preventive and curative options are numerous but little is known about their economical advantages. Selecting the intervention that offers the best balance of effectiveness and financial resources becomes crucial in the current situation of budget restrictions worldwide. Areas covered: This expert review summarizes available evidence on cost-effectiveness analyses of preventive and curative measures to manage dental caries in children...
December 7, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29207931/drug-related-deaths-statistics-based-on-death-certificates-miss-one-third-of-cases
#9
Anna Fugelstad, Mats Ramstedt, Ingemar Thiblin, Lars Age Johansson
AIMS: Statistics on drug-related deaths (DRD) provide crucial information on the drug situation. The European Monitoring Centre for Drug and Drug Addiction (EMCDDA) has published a specification for extracting DRD from national mortality registers to be used in international comparisons. However, surprisingly little is known of the accuracy of DRD statistics derived from national mortality registers. This study assesses the accuracy of Swedish data derived from national mortality registers by comparing it with other sources of data...
December 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29205995/volume-and-health-outcomes-evidence-from-systematic-reviews-and-from-evaluation-of-italian-hospital-data
#10
Laura Amato, Danilo Fusco, Anna Acampora, Katia Bontempi, Alessandro Cesare Rosa, Paola Colais, Fabio Cruciani, Mariangela D'Ovidio, Francesca Mataloni, Silvia Minozzi, Zuzana Mitrova, Luigi Pinnarelli, Rosella Saulle, Salvatore Soldati, Chiara Sorge, Simona Vecchi, Martina Ventura, Marina Davoli
BACKGROUND Improving quality and effectiveness of healthcare is one of the priorities of health policies. Hospital or physician volume represents a measurable variable with an impact on effectiveness of healthcare. An Italian law calls for the definition of «qualitative, structural, technological, and quantitative standards of hospital care». There is a need for an evaluation of the available scientific evidence in order to identify qualitative, structural, technological, and quantitative standards of hospital care, including the volume of care above or below which the public and private hospitals may be accredited (or not) to provide specific healthcare interventions...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29204104/assessing-the-consultation-and-relational-empathy-care-measure-in-sexual-health-nurses-consultations
#11
Annemieke P Bikker, Bridie Fitzpatrick, Douglas Murphy, Lorraine Forster, Stewart W Mercer
Background: Increasingly healthcare policies emphasise the importance of person-centred, empathic care. Consequently, healthcare professionals are expected to demonstrate the 'human' aspects of care in training and in practice. The Consultation and Relational Empathy (CARE) Measure is a patient-rated measure of the interpersonal skills of healthcare practitioners. It has been widely validated for use by healthcare professionals in both primary and secondary care. This paper reports on the validity and reliability of the CARE Measure with sexual health nurses...
2017: BMC Nursing
https://www.readbyqxmd.com/read/29201385/identifying-the-hidden-burden-of-allergic-rhinitis-ar-in-community-pharmacy-a-global-phenomenon
#12
Rachel Tan, Biljana Cvetkovski, Vicky Kritikos, David Price, Kwok Yan, Pete Smith, Sinthia Bosnic-Anticevich
Background: Patients with allergic rhinitis often trivialise their condition, self-manage inappropriately, and would benefit from health care intervention. The primary point of health care contact for these self-managing allergic rhinitis patients is the community pharmacy. With the majority of allergic rhinitis treatments being available for purchase over the counter, without health care professional contact, we know little about how the patients self-manage. This study aims to identify the burden of allergic rhinitis in the community pharmacy and to identify key opportunity for intervention...
2017: Asthma Research and Practice
https://www.readbyqxmd.com/read/29200340/only-one-in-twenty-justice-referred-adults-in-specialty-treatment-for-opioid-use-receive-methadone-or-buprenorphine
#13
Noa Krawczyk, Caroline E Picher, Kenneth A Feder, Brendan Saloner
People in the US criminal justice system experience high rates of opioid use disorder, overdose, and other adverse outcomes. Expanding treatment is a key strategy for addressing the opioid epidemic, but little is known about whether the criminal justice system refers people to the highest standard of treatment: the use of the opioid agonist therapies methadone or buprenorphine. We used 2014 data from the national Treatment Episode Data Set to examine the use of agonist treatment among justice-involved people referred to specialty treatment for opioid use disorder...
December 2017: Health Affairs
https://www.readbyqxmd.com/read/29196903/concurrent-use-of-prescription-drugs-and-herbal-medicinal-products-in-older-adults-a-systematic-review
#14
REVIEW
Taofikat B Agbabiaka, Barbara Wider, Leala K Watson, Claire Goodman
BACKGROUND: The use of herbal medicinal products (HMPs) is common among older adults; however, little is known about concurrent use with prescription drugs, as well as potential interactions associated with such combinations. OBJECTIVE: The aim of this systematic review was to identify and evaluate the literature on concurrent prescription and HMP use among older adults to assess prevalence, patterns, potential interactions and factors associated with this use. METHODS: Systematic searches were conducted in the MEDLINE, PsycINFO, EMBASE, CINAHL, AMED, Web of Science and Cochrane databases from inception to May 2017 for studies reporting concurrent use of prescription medicines with HMPs in adults ≥ 65 years of age...
December 1, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29192227/conservation-of-nonsense-mediated-mrna-decay-complex-components-throughout-eukaryotic-evolution
#15
Barry Causier, Zhen Li, Riet De Smet, James P B Lloyd, Yves Van de Peer, Brendan Davies
Nonsense-mediated mRNA decay (NMD) is an essential eukaryotic process regulating transcript quality and abundance, and is involved in diverse processes including brain development and plant defenses. Although some of the NMD machinery is conserved between kingdoms, little is known about its evolution. Phosphorylation of the core NMD component UPF1 is critical for NMD and is regulated in mammals by the SURF complex (UPF1, SMG1 kinase, SMG8, SMG9 and eukaryotic release factors). However, since SMG1 is reportedly missing from the genomes of fungi and the plant Arabidopsis thaliana, it remains unclear how UPF1 is activated outside the metazoa...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29189976/validation-of-knowledge-and-adherence-assessment-tools-among-patients-on-warfarin-therapy-in-a-saudi-hospital-anticoagulant-clinic
#16
Sireen Abdul Rahim Shilbayeh, Wejdan Ali Almutairi, Sarah Ahmed Alyahya, Nouf Hayef Alshammari, Eiad Shaheen, Alya Adam
Background Although it can result in serious complications due to its narrow therapeutic index, warfarin is widely used in the treatment and prevention of thromboembolic disorders. However, patients' adherence and knowledge are determinants of therapeutic success. Objective We sought to validate instruments to provide a reliable means of identifying gaps in patient understanding and nonadherence to inform targeted pharmacists' interventions to improve these measures. Methods A cross-sectional survey was conducted...
November 30, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29189352/metagenomics-in-pediatrics-using-a-shotgun-approach-to-diagnose-infections
#17
Jeffrey M Bender, Jennifer Dien Bard
PURPOSE OF REVIEW: With the advent of novel massively parallel sequencing technologies and bioinformatic processing capabilities, clinical applications of metagenomic studies are rapidly being integrated into medicine. Through this paper, we hope to introduce this powerful new tool to clinicians caring for children. RECENT FINDINGS: Very few studies have looked at metagenomic applications in children. The ability to perform these types of massive sequencing projects was not possible as little as 7 years ago...
November 17, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29186350/macrophage-enzyme-and-reduced-inflammation-drive-brain-correction-of-mucopolysaccharidosis-iiib-by-stem-cell-gene-therapy
#18
Rebecca J Holley, Stuart M Ellison, Daniel Fil, Claire O'Leary, John McDermott, Nishanthi Senthivel, Alexander W W Langford-Smith, Fiona L Wilkinson, Zelpha D'Souza, Helen Parker, Aiyin Liao, Samuel Rowlston, Hélène F E Gleitz, Shih-Hsin Kan, Patricia I Dickson, Brian W Bigger
Mucopolysaccharidosis IIIB is a paediatric lysosomal storage disease caused by deficiency of the enzyme α-N-acetylglucosaminidase (NAGLU), involved in the degradation of the glycosaminoglycan heparan sulphate. Absence of NAGLU leads to accumulation of partially degraded heparan sulphate within lysosomes and the extracellular matrix, giving rise to severe CNS degeneration with progressive cognitive impairment and behavioural problems. There are no therapies. Haematopoietic stem cell transplant shows great efficacy in the related disease mucopolysaccharidosis I, where donor-derived monocytes can transmigrate into the brain following bone marrow engraftment, secrete the missing enzyme and cross-correct neighbouring cells...
November 27, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29184612/efficacy-of-prucalopride-in-bowel-cleansing-before-colonoscopy-results-of-a-pilot-study
#19
Vito Domenico Corleto, Giulio Antonelli, Chiara Coluccio, Lucia D'Alba, Emilio di Giulio
Colonoscopy is a crucial diagnostic instrument for colorectal cancer screening and an adequate bowel preparation is definitely decisive for the success of the procedure. Especially in elderly patients, bowel cleansing is considered a big issue, because it is often poorly tolerated for many reasons (like inability to swallow large volume of liquids or unlikable taste); this can cause a suboptimal preparation that may lead to miss a neoplastic lesion. There is relatively little data about how to improve preparation tolerability...
November 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29183304/dental-caries-experience-and-determinants-in-young-adults-of-the-northern-state-medical-university-arkhangelsk-north-west-russia-a-cross-sectional-study
#20
Sergei N Drachev, Tormod Brenn, Tordis A Trovik
BACKGROUND: Little information exists about the experience of and risk factors for dental caries in young adults in Russia. We investigated dental caries experience and determinants in medical and dental students in North-West Russia. METHODS: This cross-sectional study included 442 medical and 309 dental undergraduate students of Russian nationality aged 18-25 years from the Northern State Medical University, Arkhangelsk, Russia. Information on socio-demographic factors and oral health behaviour (regularity of dental visits, frequency of tooth-brushing, using toothpaste with fluoride, and skipping tooth-brushing) was obtained from a structured, self-administered questionnaire...
November 28, 2017: BMC Oral Health
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