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JOURNAL ARTICLE
Sameer Thadani, Dana Fuhrman, Claire Hanson, Hyun Jung Park, Joseph Angelo, Poyyapakkam Srivaths, Katri Typpo, Michael J Bell, Katja M Gist, Joseph Carcillo, Ayse Akcan-Arikan
OBJECTIVES: Acute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal replacement therapy (CRRT) is the modality of choice for AKI-D. Mid-term outcomes of pediatric AKI-D supported with CRRT are unknown. We aimed to describe the pattern and impact of organ dysfunction on renal outcomes in critically ill children and young adults with AKI-D. DESIGN: Retrospective cohort. SETTING: Two large quarternary care pediatric hospitals...
May 1, 2024: Critical care explorations
#2
Jonathan I Witonsky, Jennifer R Elhawary, Celeste Eng, Sam S Oh, Sandra Salazar, Maria G Contreras, Vivian Medina, Elizabeth A Secor, Priscilla Zhang, Jamie L Everman, Ana Fairbanks-Mahnke, Elmar Pruesse, Satria P Sajuthi, Chih-Hao Chang, Tsunami Rosado Guerrero, Keyshla Canales Fuentes, Natalie Lopez, Chris Angely Montanez-Lopez, Richeliz Alfonso Otero, Raymarie Colon Rivera, Leysha Rodriguez, Gabriela Vazquez, Donglei Hu, Scott Huntsman, Nathan D Jackson, Yingchun Li, Andrew Morin, Natalie A Nieves, Cydney Rios, Gonzalo Serrano, Blake J M Williams, Elad Ziv, Camille M Moore, Dean Sheppard, Esteban Gonzalez Burchard, Max A Seibold, Jose R Rodriguez Santana
Epidemiologic studies demonstrate an association between early-life respiratory illnesses (RIs) and the development of childhood asthma. However, it remains uncertain whether these children are predisposed to both conditions or if early-life RIs induce alterations in airway function, immune responses, or other human biology that contribute to the development of asthma. Puerto Rican children experience a disproportionate burden of early-life RIs and asthma, making them an important population for investigating this complex interplay...
April 16, 2024: medRxiv
#3
JOURNAL ARTICLE
Alexandra H Ferguson, Kellie A Stockton, Sarah E Wright, Joanne M George, Tessa J Fulton, Christian Stocker, Debbie A Long
OBJECTIVES: To adapt and develop a reliable and easily administered outcome measure of physical and respiratory function in critically ill children in the PICU. DESIGN: Modified Delphi study to adapt the Chelsea Critical Care Physical Assessment (CPAx) tool for use in children 2-18 years old, with subsequent prospective testing in a single-center cohort. SETTING: Single-center tertiary PICU. SUBJECTS: Delphi process in 27 panelists (including physiotherapists, occupational therapists, and pediatric intensivists from seven countries from January 2018 to March 2018)...
May 1, 2024: Pediatric Critical Care Medicine
#4
JOURNAL ARTICLE
Mark D Weber, Charlotte Woods-Hill, Karla Resendiz, Eileen Nelson, Monica Ryan, Lauren Brennan, Abhay Srinivasan, Thomas Conlon
OBJECTIVES: Ethanol lock therapy (ELT) is a potential method of central catheter salvage following central line-associated bloodstream infection (CLABSI) although there is potential risk of catheter damage in polyurethane catheters. Further, there is limited efficacy data across the spectrum of common pediatric catheters, and published ELT protocols describe dwell times that are not feasible for critically ill children. We sought to evaluate the safety and efficacy of ELT in polyurethane catheters using brief (30 min to 2 hr) dwell times in our PICU...
May 1, 2024: Pediatric Critical Care Medicine
#5
JOURNAL ARTICLE
Alireza Akhondi-Asl, Alon Geva, Jeffrey P Burns, Nilesh M Mehta
OBJECTIVES: The pediatric Sequential Organ Failure Assessment (pSOFA) score was designed to track illness severity and predict mortality in critically ill children. Most commonly, pSOFA at a point in time is used to assess a static patient condition. However, this approach has a significant drawback because it fails to consider any changes in a patients' condition during their PICU stay and, especially, their response to initial critical care treatment. We aimed to evaluate the performance of longitudinal pSOFA scores for predicting mortality...
May 1, 2024: Pediatric Critical Care Medicine
#6
JOURNAL ARTICLE
Carlos Plancarte, Tess Stopczynski, Lubna Hamdan, Laura S Stewart, Herdi Rahman, Justin Z Amarin, James Chappell, Mary E Wikswo, John R Dunn, Daniel C Payne, Aron J Hall, Andrew J Spieker, Natasha Halasa
OBJECTIVE: Acute gastroenteritis (AGE) is the second leading cause of death in children worldwide. Objectively evaluating disease severity is critical for assessing future interventions. We used data from a large, prospective surveillance study to assess risk factors associated with severe presentation using modified Vesikari score (MVS) and Clark score (CS) of severity. METHODS: From December 1, 2012 to June 30, 2016, AGE surveillance was performed for children between 15 days and 17 years old in the emergency, inpatient, and outpatient settings at Vanderbilt's Monroe Carell Jr...
May 2, 2024: Hospital Pediatrics
#7
JOURNAL ARTICLE
Sudarsan Krishnasamy, Aditi Sinha, Rakesh Lodha, Jhuma Sankar, Mohamad Tarik, Lakshmy Ramakrishnan, Arvind Bagga, Pankaj Hari
BACKGROUND: Furosemide stress test (FST) is a novel functional biomarker for predicting severe acute kidney injury (AKI); however, pediatric studies are limited. METHODS: Children 3 months to 18 years of age admitted to the intensive care unit (ICU) of a tertiary care hospital from Nov 2019 to July 2021 were screened and those who developed AKI stage 1 or 2 within 7 days of admission underwent FST (intravenous furosemide 1 mg/kg). Urine output was measured hourly for the next 6 h; a value > 2 ml/kg within the first 2 h was deemed furosemide responsive...
April 30, 2024: Pediatric Nephrology
#8
JOURNAL ARTICLE
Na Zhang, Zhen Wang, Hong Li, Kai Chen, Hong-Sheng Wang, Jing-Bo Shao, Sha-Yi Jiang, Xiao-Wen Zhai, Hui Jiang
BACKGROUND: Patients with immunocompromise were suspected to encounter a high risk for severe coronavirus disease 2019 (COVID-19) infection on early period; however, data is lacking nowadays and immune response remain unclear. METHODS: In this retrospective study, internet questionnaire survey and medical records were acquired in pediatric hematology oncology patients. Clinical severity, immunological characteristics, and outcomes were analyzed from December 1, 2022 to January 31, 2023 at the 3rd year of pandemic in China...
April 27, 2024: BMC Cancer
#9
REVIEW
Jon A Cokley, Steven M Lazar
Clinical pharmacists are a part of the integrated health care team and provide valuable input on medication management for patients with acute and chronic disease states. Using epilepsy as a model, pharmacist involvement in patient care has been associated with significant reductions in monthly seizure frequency. Given differences in etiology, pediatric patients with epilepsy are likely to have higher number of treatments, with additional pharmacodynamic and pharmacokinetic differences, adding to the importance of utilizing a pediatric clinical pharmacist practitioner with neuropharmacology expertise...
April 2024: Seminars in Pediatric Neurology
#10
REVIEW
Leslie H Hayes, Basil T Darras
Acute neuromuscular disorders occasionally occur in the Pediatric Neurologic Intensive Care Unit. Many of these are primary disorders of the motor unit that may present acutely or exacerbate during an intercurrent illness. Additionally, acute neuromuscular disorders may develop during an acute systemic illness requiring intensive care management that predispose the child to another set of acute motor unit disorders. This chapter discusses acute neuromuscular crises in the infant, toddler, and adolescent, as well as neuromuscular disorders resulting from critical illness...
April 2024: Seminars in Pediatric Neurology
#11
REVIEW
Alexander Ankar, Emily Hermes, Catherine Wheless, Gabrielle Nguyen, Taryn Townsend, Sarah Risen
Children admitted to neurocritical care units often experience new neurodevelopmental disabilities due to both their acquired neurologic injuries and deconditioning from prolonged hospitalizations. Rehabilitation for critically ill children is multifactorial and begins in the intensive care unit itself. The goals of rehabilitation include prevention of complications associated with immobilization and evolving tone, comprehensive evaluation and treatment of functional deficits, and implementation of adaptive strategies with the goal of maximizing recovery...
April 2024: Seminars in Pediatric Neurology
#12
REVIEW
Thao L Nguyen, Dennis W Simon, Yi-Chen Lai
Managing children with critical neurological conditions requires a comprehensive understanding of several principles of critical care. Providing a holistic approach that addresses not only the acute interactions between the brain and different organ systems, but also critical illness-associated complications and recovery is essential for improving outcomes in these patients. The brain reacts to an insult with autonomic responses designed to optimize cardiac output and perfusion, which can paradoxically be detrimental...
April 2024: Seminars in Pediatric Neurology
#13
REVIEW
Raquel Farias-Moeller, Nora Wong
The post-intensive care syndrome (PICS) concept whereby the ICU experience of the patient as well as their family can have long-term deleterious health outcomes in both the patient and the family provides a rationale and impetus for modifying the ICU experience for the parents of patients receiving pediatric neurocritical care. This article uses the PICS framework to provide insight to that parental experience. Included are the words of parents who tell what they felt and what they most needed from their children's doctors while their children were receiving neurocritical care...
April 2024: Seminars in Pediatric Neurology
#14
JOURNAL ARTICLE
Fajr A Saeedi, Moustafa A Hegazi, Hani Alsaedi, Ahmed Hussain Alganmi, Jawahir A Mokhtar, Eilaf Majdi Metwalli, Hanaa Hamadallah, Ghassan S Siam, Abdullah Alaqla, Abdullah Alsharabi, Sultan Ahmed Alotaibi
Multidrug-resistant bacterial infections (MDRIs) constitute a major global threat due to increased patient morbidity/mortality and hospital stay/healthcare costs. A few studies from KSA, including our locality, addressed antimicrobial resistance in pediatric patients. This study was performed to recognize the incidence and clinical/microbiologic features of MDRIs in hospitalized pediatric patients. A retrospective cross-sectional study included pediatric patients < 18 years, admitted to King Abdulaziz University Hospital, between October 2021 and November 2022, with confirmed positive cultures of bacteria isolated from blood/body fluids...
April 7, 2024: Children
#15
JOURNAL ARTICLE
Tommaso Zini, Lucia Corso, Cinzia Mazzi, Cecilia Baraldi, Elisa Nieddu, Laura Rinaldi, Francesca Miselli, Luca Bedetti, Eugenio Spaggiari, Katia Rossi, Alberto Berardi, Licia Lugli, On Behalf Of The Cvc Study Group
BACKGROUND: Centrally inserted central catheters (CICCs) are increasingly used in neonatal care. CICCs have garnered attention and adoption owing to their advantageous features. Therefore, achieving clinical competence in ultrasound-guided CICC insertion in term and preterm infants is of paramount importance for neonatologists. A safe clinical training program should include theoretical teaching and clinical practice, simulation and supervised CICC insertions. METHODS: We planned a training program for neonatologists for ultrasound-guided CICCs placement at our level III neonatal intensive care unit (NICU) in Modena, Italy...
March 26, 2024: Children
#16
JOURNAL ARTICLE
Aweke Tadesse, Jesse J Helton, Kenan Li
This study investigates the well-being of primary caregivers responsible for orphaned and vulnerable children. Well-being is defined as overall wellness, happiness, and satisfaction. Through mixed methods case studies and purposive sampling, we analyzed data from the Ziway Food for the Hungry Ethiopia program in 2017. Our explanatory analytic approach highlighted issues including resource constraints, chronic illnesses, and community challenges faced by the respondents. Nonetheless, spiritual well-being emerged as a crucial factor for their coping mechanisms...
March 22, 2024: Children
#17
JOURNAL ARTICLE
Micah Kadden, Anqing Zhang, Michael Shoykhet
OBJECTIVE: To determine whether ICU temperature management strategy is associated with fever in children with return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA). METHODS: We conducted a single-center retrospective cohort study at a quaternary Children's hospital between 1/1/2016-31/12/2020. Mechanically ventilated children (<18 y/o) admitted to Pediatric or Cardiac ICU (PICU/CICU) with ROSC after OHCA who survived at least 72 h were included...
2024: Frontiers in Pediatrics
#18
JOURNAL ARTICLE
Ceyhun Bozkurt, Volkan Hazar, Barış Malbora, Alphan Küpesiz, Utku Aygüneş, Tunç Fışgın, Musa Karakükçü, Barış Kuşkonmaz, Suar Çakı Kılıç, Derya Bayırlı, Özlem Arman Bilir, Koray Yalçın, Salih Gözmen, Vedat Uygun, Murat Elli, Hakan Sarbay, Funda Tayfun Küpesiz, Hatice İlgen Şaşmaz, Başak Adaklı Aksoy, Ebru Yılmaz, Fatma Visal Okur, Funda Tekkeşin, Fatma Demir Yenigürbüz, Gülcihan Özek, Abdullah Avni Atay, İkbal Ok Bozkaya, Suna Çelen, Seda Öztürkmen, Adalet Meral Güneş, Orhan Gürsel, Elif Güler, Alper Özcan, Duygu Uçkan Çetinkaya, Selime Aydoğdu, Namık Yaşar Özbek, Gülsün Karasu, Gülay Sezgin, Ömer Doğru, Davut Albayrak, Gülyüz Öztürk, Serap Aksoylar, Hayriye Daloğlu, Işık Odaman Al, Melike Sezgin Evim, Sinan Akbayram, Yurday Öncül, Emine Zengin, Canan Albayrak, Çetin Timur, Yeter Düzenli Kar, Hasan Fatih Çakmaklı, Özlem Tüfekçi, Ersin Töret, Bülent Antmen
BACKGROUND: Data on the risk factors and outcomes for pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. OBJECTIVES: The study aimed to analyze the clinical signs, risk factors, and outcomes for ICU admission and mortality in a large pediatric cohort who underwent allogeneic HSCT prior to COVID-19 infection. METHOD: In this nationwide study, we retrospectively reviewed the data of 184 pediatric HSCT recipients who had COVID-19 between March 2020 and August 2022...
May 2024: Pediatric Transplantation
#19
REVIEW
Reinout A Bem, Joris Lemson
PURPOSE OF REVIEW: To review the evaluation and management of fluid overload in critically ill children. RECENT FINDINGS: Emerging evidence associates fluid overload, i.e. having a positive cumulative fluid balance, with adverse outcome in critically ill children. This is most likely the result of impaired organ function due to increased extravascular water content. The combination of a number of parameters, including physical, laboratory and radiographic markers, may aid the clinician in monitoring and quantifying fluid status, but all have important limitations, in particular to discriminate between intra- and extravascular water volume...
June 1, 2024: Current Opinion in Pediatrics
#20
JOURNAL ARTICLE
Mahmoud Khodabandeh, Elham Moradian, Maedeh Sarvari, Mahsa Soti Khiabani
BACKGROUND: Black disease, also known as visceral leishmaniasis (VL), is a parasitic illness caused by various Leishmania species. The risk of morbidity and mortality increases with delayed diagnosis and treatment. Early VL diagnosis and fast appropriate treatment are critical issues in endemic areas. METHODS: This study was a retrospective cross-sectional study to investigate the diagnostic and therapeutic course of patients admitted with the diagnosis of VL in the Children's Medical Center (CMC) Hospital, Tehran, Iran...
2024: Iranian Journal of Parasitology
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