Yafei Mao, William T Harvey, David Porubsky, Katherine M Munson, Kendra Hoekzema, Alexandra P Lewis, Peter A Audano, Allison Rozanski, Xiangyu Yang, Shilong Zhang, David S Gordon, Xiaoxi Wei, Glennis A Logsdon, Marina Haukness, Philip C Dishuck, Hyeonsoo Jeong, Ricardo Del Rosario, Vanessa L Bauer, Will T Fattor, Gregory K Wilkerson, Qing Lu, Benedict Paten, Guoping Feng, Sara L Sawyer, Wesley C Warren, Lucia Carbone, Evan E Eichler
To better understand the pattern of primate genome structural variation, we sequenced and assembled using multiple long-read sequencing technologies the genomes of eight nonhuman primate species, including New World monkeys (owl monkey and marmoset), Old World monkey (macaque), Asian apes (orangutan and gibbon), and African ape lineages (gorilla, bonobo, and chimpanzee). Compared to the human genome, we identified 1,338,997 lineage-specific fixed structural variants (SVs) disrupting 1,561 protein-coding genes and 136,932 regulatory elements, including the most complete set of human-specific fixed differences...
March 7, 2023: bioRxiv