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hypothyroidism in type 2 diabetes

Thomas Gilliland, Sylvie Dufour, Gerald I Shulman, Kitt Falk Petersen, Sukru H Emre
NAFLD is a common condition linked to obesity, type 2 diabetes, and metabolic syndrome. Simple hepatic steatosis is a risk factor for inflammatory reactions in the liver (NASH), which may lead to cirrhosis. While the mechanism is unclear, NAFLD and NASH are associated with panhypopituitarism, which in the pediatric population often results from craniopharyngioma or pituitary adenoma and the sequelae of treatment, causing hypothyroidism, adrenal insufficiency, hypogonadotropic hypogonadism, and GH deficiency...
October 20, 2016: Pediatric Transplantation
Imran M Paruk, Yasmeen Ganie, Sureka Maharaj, Fraser J Pirie, Vasudevan G Naidoo, Ntombifikile M Nkwanyana, Hilary L Dinnematin, Pratistadevi K Ramdial, Ayesha A Motala
OBJECTIVE: Data on the prevalence of autoimmune thyroid disease (AITD) and gastric autoimmunity in type 1 diabetes mellitus (T1DM) in Africa are limited. The aim of this study was to assess the prevalence of antithyroid peroxidase (TPO-A) and antiparietal cell antibody (PCA) in patients with T1DM at a tertiary diabetes clinic in Durban, South Africa. RESEARCH DESIGN AND METHODS: This was a cross-sectional observational study among subjects attending the adult T1DM clinic at Inkosi Albert Luthuli Hospital...
October 14, 2016: Postgraduate Medical Journal
N Mansournia, S Riyahi, S Tofangchiha, M A Mansournia, M Riahi, Z Heidari, E Hazrati
PURPOSE: Association of subclinical hypothyroidism with type 2 diabetes and its complications has been previously documented. These reports were, however, inconclusive and mainly gathered from Chinese and East Asian populations. In this study, we aimed to determine the prevalence of subclinical hypothyroidism and its relationship with diabetic nephropathy in Iranian individuals with type 2 diabetes, drawn from a white Middle Eastern population with an increasing prevalence of diabetes...
October 13, 2016: Journal of Endocrinological Investigation
R Katyayini, Vijay M Benglorkar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Abdul Rehman Arshad, Hamid Nawaz Tipu, Athar Iqbal Paracha
OBJECTIVE: To study the effect of hypertension on lipid levels in patients with type 2 diabetes mellitus. METHODS: This prospective, observational study was conducted at 1 Mountain Medical Battalion, Bagh, Azad Kashmir, from May 2012 to April 2015, and comprised adult type 2 diabetics. Patients already on lipid-lowering agents, hypothyroidism, nephrotic syndrome, unwilling patients and those who had serum triglycerides>4.5mmol/l were excluded. Blood pressure was measured twice in sitting position...
October 2016: JPMA. the Journal of the Pakistan Medical Association
Layal Chaker, Symen Ligthart, Tim I M Korevaar, Albert Hofman, Oscar H Franco, Robin P Peeters, Abbas Dehghan
BACKGROUND: The association of thyroid function with risk of type 2 diabetes remains elusive. We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes in a population-based prospective cohort study. METHODS: We included 8452 participants (mean age 65 years) with thyroid function measurement, defined by thyroid-stimulating hormone (TSH) and free thyroxine (FT4), and longitudinal assessment of diabetes incidence...
September 30, 2016: BMC Medicine
Shahrzad Bakhtiar, Frank Ruemmele, Fabienne Charbit-Henrion, Eva Lévy, Frédéric Rieux-Laucat, Nadine Cerf-Bensussan, Peter Bader, Ulrich Paetow
Monogenic primary immunodeficiency syndromes can affect one or more endocrine organs by autoimmunity during childhood. Clinical manifestations include type 1 diabetes mellitus, hypothyroidism, adrenal insufficiency, and vitiligo. Lipopolysaccharide (LPS)-responsive beige-like anchor protein (LRBA) deficiency was described in 2012 as a novel primary immunodeficiency, predominantly causing immune dysregulation and early onset enteropathy. We describe the heterogeneous clinical course of LRBA deficiency in two siblings, mimicking an autoimmune polyendocrine disorder in one of them in presence of the same underlying genetic mutation...
2016: Frontiers in Pediatrics
David Krahulik, Darina Aleksijevic, Vratislav Smolka, Eva Klaskova, Petra Venhacova, Miroslav Vaverka, Vladimir Mihal, Jirina Zapletalova
BACKGROUND AND AIMS: Retrospective studies of TBI have found a neuroendocrine dysfunction following traumatic brain injury in 23 to 60% of adults and 15 to 21% of children. Our aims were to determine the prevalence of hypothalamo-hypophyseal dysfunction in children following brain injury, assess its relationship to the type of injury and the course of the acute post-traumatic phase. PATIENTS AND METHODS: Body development (growth, pubertal development, and skeletal maturity) were evaluated in 58 patients (21 girls) after a brain injury rated 3 to 12 on the Glasgow Coma Scale (GCS)...
September 19, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Gurmit Gill, Hammad Bajwa, Peter Strouhal, Harit N Buch
BACKGROUND: Interferon alpha is a widely used therapeutic agent in the treatment of hepatitis C virus infection. Clinical thyroid disease is seen in nearly 15 % of patients receiving interferon alpha for hepatitis C virus infection. The mechanism of thyroid dysfunction with interferon alpha is either autoimmune or inflammatory. We report a case of young woman who developed biphasic thyroid dysfunction posing a diagnostic challenge, while receiving interferon alpha treatment for hepatitis C virus infection...
2016: Journal of Medical Case Reports
Fei Song, Cuiping Bao, Meiyu Deng, Hui Xu, Meijuan Fan, Stéphanie Paillard-Borg, Weili Xu, Xiuying Qi
The purpose of this study was to investigate the prevalence of hypothyroidism among hospitalized patients with type 2 diabetes mellitus and its related factors, and to assess the prevalence of macrovascular and microvascular diseases among type 2 diabetes mellitus inpatients with hypothyroidism and euthyroidism. A total of 1662 type 2 diabetes mellitus inpatients hospitalized at the Metabolic Diseases Hospital, Tianjin Medical University from 1 January 2008 to 1 March 2013 were included in this study. Information on demographic and anthropometric factors and additional variables related to hypothyroidism were collected from medical records...
September 7, 2016: Endocrine
Dante S Harbuwono, Laurentius A Pramono, Hari Hendarto, Imam Subekti
This is a case of 51 year-old woman with uncontrolled type 2 diabetes mellitus which was diagnosed 1.5 year earlier, obesity with body mass index 32.2 kg/m2, waist circumference of 113 cm, diffuse goiter with neck circumference 40 cm, and hypertension with blood pressure >140/90 mmHg. Since 6 months ago, she often seemed like having less concentration or daydreaming, chronic fatigue, depression, and low food intake. Her body weight had been increasing over time. Her hypothyroidism clinical scoring Billewicz and Zulewski criterias were 17 and 8 respectively, showing that she tended to experience hypothyroidism...
April 2016: Acta Medica Indonesiana
D Dimic, M Velojic Golubovic, S Radenkovic, D Radojkovic, M Pesic
INTRODUCTION: Metformin is the first-line oral hypoglycemic agent in the treatment of type 2 diabetes mellitus with a number of positive effects. The aim of the study was to determine the effect of metformin on TSH levels in euthyroid and hypothyroid newly diagnosed diabetes mellitus type 2 patients. MATERIAL AND METHODS: The study included 255 newly diagnosed diabetes mellitus type 2 drug naive patients, 170 euthyroid patinets, group A, 85 hypothiroid patients, group B, and 80 euthyroid DM type 2 patients on metformin therapy for more than 5 years, group C...
2016: Bratislavské Lekárske Listy
X Fu, H Xia, H Mao, S Zhao, Z Wang
OBJECTIVE: The purpose of this study was to investigate the effect of glycaemic control on subclinical hypothyroidism (SCH) in Chinese type 2 diabetic patients. METHODS: The study included 476 diabetic patients with SCH admitted for treatment of type 2 diabetes. The controls were selected euthyroid patients with similar characteristics regarding [age, body mass index (BMI), gender, previous hypertension or duration of diabetes, and smoke]. Total cholesterol (TC), LDL cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), the homeostatic model assessment of insulin resistance ratio (HOMA-IR), fasting plasma glucose, hemoglobin A1c (HbA1c), as well as plasma levels of thyrotrophin, and free thyroxine (FT4) were assessed at baseline and after 6 months of glycaemic control treatment...
July 30, 2016: Journal of Endocrinological Investigation
Şükrü Hatun, Hüseyin Demirbilek, Şükran Darcan, Ayşegül Yüksel, Cigdem Binay, Damla Gökşen Şimşek, Cengiz Kara, Ergun Çetinkaya, Tolga Ünüvar, Ahmet Uçaktürk, Filiz Tütüncüler, Yaşar Cesur, Ruveyde Bundak, Halil Sağlam, Enver Şimşek, Abdullah Bereket
AIMS: To evaluate the management strategies, glycemic control and complications of pediatric type 1 diabetes mellitus (T1DM) patients in Turkey. METHODS: Study included 498 patients with T1DM between the ages 1-18. Data provided from patients' hospital files were recorded on standard case report forms by applicant clinicians within the 3months of data collection period between October 2012 and July 2013. RESULTS: Mean age of patients was 11...
September 2016: Diabetes Research and Clinical Practice
Lin Zhang, Guangran Yang, Zhiyan Su, Jinkui Yang
AIM: To evaluate the incidence of and risk factors for subclinical hypothyroidism (SCH) in patients with type 2 diabetes mellitus (T2D), and determine the association of SCH with renal function. METHODS: T2D patients hospitalized between June 2007 and July 2008 were cross-sectionally assessed. Clinical indicators and renal function were compared between the SCH and normal thyroid function groups. Risk factors for SCH and diabetic renal injury (albuminuria) were evaluated by univariate and multivariate analyses...
July 14, 2016: Nephrology
Hoffmann Anika, Hermann L MüLLER
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) presents a disease with a wide spectrum spanning from benign steatosis to steatohepatitis with fibrosis and scarring that can lead to cirrhosis. With increasing prevalence, NAFLD is developing into the leading indication for liver transplantation worldwide. Disturbances in endocrine, hypothalamic-pituitary axes have been associated with NALFD, including GH deficiency, hypothyroidism, hypercortisolaemia, and hypogonadism. EVIDENCE OF ACQUISITION AND SYNTHESIS: In this review, we examine the published data (search: PUBMED, 1990-2016) suggesting a link between endocrine abnormalities of hypothalmic-pituitary axes and NAFLD and summarise the clinical data on risk factors for NAFLD in specific diseases involving hypothalmic-pituitary axes...
July 13, 2016: Minerva Endocrinologica
Fahim Ullah, Tahir Ghaffar, Ayesha Khan Afridi, Ashfaq Ali, Aziz ul hasan Aamir
BACKGROUND: Globally children and adolescents with growth failure are referred to specialized units for evaluation and management. We designed this study to determine the cause of short stature in children and adolescents referred to our endocrine unit for evaluation and further management. METHODS: This descriptive cross sectional study was performed in the Department of Endocrine, Diabetes and Metabolic Diseases, Hayatabad Medical Complex, Peshawar. Children and adolescents between 2-20 years with height below 2 SDS or less then 3rd percentile for their age and gender were included while those with kyphoscoliosis, thalassemia major, diabetes mellitus type-1 were excluded...
January 2016: Journal of Ayub Medical College, Abbottabad: JAMC
Ken-Ichi Morishita, Hiroki Kakuta
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent transcription factor that plays an important role in regulating glucose metabolism. Agonists of PPARγ, such as thiazolidinediones, have anti-hyperglycemic activity, and are therefore used to treat type 2 diabetes. However, the functional activity of PPARγ is manifested by heterodimers of PPARγ with retinoid X receptors (RXRs). Since RXR/PPARγ heterodimers can be activated not only by PPARγ agonists, but also by RXR agonists, RXR agonists are also attractive candidates for treatment of type 2 diabetes...
June 16, 2016: Current Topics in Medicinal Chemistry
Moein Foroughi, Majid Malekmohammad, Parisa Adimi
Obstructive sleep apnea (OSA) together with metabolic disorders is common in severely obese patients. Weight reduction is considered as a treatment modality in these cases while few of them can succeed in considerable weight loss. Here, we present a severely obese man with body mass index of 54 suffered from OSA, type 2 diabetes, hypothyroidism, and hypertension. He intentionally lost 80 kilograms weight during the 2-year follow-up. Diabetes and hypertension completely resolved with considerable improvement in OSA syndrome after this huge weight reduction...
May 2016: Acta Medica Iranica
Beata Całyniuk, Elżbieta Grochowska-Niedworok, Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Marcin Osowski
BACKGROUND: Excess body weight is one of the most common health and economic problems of the contemporary world. According to the assessments of the World Health Organization (WHO), almost billion adults are overweight and at least 300 million were diagnosed with clinical obesity. Health consequences of overweight are: ischemic heart disease, congestive cardiac failure, hypertension, arteriosclerotic vascular disease, diabetes mellitus type 2, tumours, degenerative joint disease and many more...
2016: Roczniki Państwowego Zakładu Higieny
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