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https://www.readbyqxmd.com/read/28211341/food-protein-induced-enterocolitis-syndrome
#1
REVIEW
A Nowak-Węgrzyn, E Jarocka-Cyrta, Apb Moschione Castro
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-, cell-mediated food allergy of unknown prevalence and pathophysiology. Onset is typically during the first year of life; seafood-induced FPIES may start in adulthood. Acute FPIES manifests within 1-4 hours after ingestion with repetitive emesis, pallor, and lethargy progressing to dehydration and hypovolemic shock in 15% of cases. Chronic FPIES manifests with intermittent emesis, watery diarrhea, and poor growth progressing to dehydration and hypovolemic shock over a period of days to weeks...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28209267/assessment-of-volume-status-and-appropriate-fluid-replenishment-in-the-setting-of-nephrotic-syndrome
#2
Pierluigi Marzuillo, Stefano Guarino, Andrea Apicella, Rosaria Marotta, Vincenzo Tipo, Laura Perrone, Angela La Manna, Giovanni Montini
BACKGROUND: When the permeability of the glomerular filtration barrier increases, leading to proteinuria, nephrotic syndrome (NS) occurs. First episodes or relapses of NS can be concurrent with acute gastroenteritis (AGE) infections. This condition can cause further deterioration of the hypovolemic state, as intravascular water is lost through both AGE-related vomiting/diarrhea and NS-related fluid shifting into the interstitium. In this case report, we wish to raise the issues about the difficult management of children presenting with both NS and AGE...
February 10, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28198551/prevalence-and-clinical-profile-of-human-bocavirus-in-children-with-acute-gastroenteritis-in-chengdu-west-china-2012-2013
#3
Tao Zhou, Yuhang Chen, Jiayi Chen, Pengwei Hu, Tianli Zheng, Xin Xu, Xiaofang Pei
Viral acute gastroenteritis (AGE) is a major cause of mortality in childhood and leads to hospitalization in developing countries. Human bocavirus (HBoV) is a newly described virus associated with gastroenteritis. However, little is known about the clinical and epidemiological profile of human bocavirus (HBoV) in pediatric population in Chengdu, China. Between January 2012 and December 2013, 346 fecal samples from children admitted to hospital with acute gastroenteritis were tested for the presence of HBoV as well as other gastroenteritis viruses...
February 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28195066/successful-therapy-of-clostridium-difficile-infection-with-fecal-microbiota-transplantation
#4
P C Konturek, J Koziel, W Dieterich, D Haziri, S Wirtz, I Glowczyk, K Konturek, M F Neurath, Y Zopf
Clostridium difficile infection (CDI) is the most common cause of infectious diarrhea and represents an important burden for healthcare worldwide. Symptoms of severe CDI include watery, foul-smelling diarrhea, peripheral leucocytosis, increased C-reactive protein (CRP), acute renal failure, hypotension and pseudomembranous colitis. Recent studies indicate that the main cause of CDI is dysbiosis, an imbalance in the normal gut microbiota. The restoration of a healthy gut microbiota composition via fecal microbiota transplantation (FMT) recently became more popular...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28192107/gastrointestinal-complications-of-obesity
#5
Michael Camilleri, Harmeet Malhi, Andres Acosta
Obesity is usually associated with morbidity related to diabetes mellitus and cardiovascular diseases. However, there are many gastrointestinal and hepatic diseases for which obesity is the direct cause [e.g. non-alcoholic fatty liver diseases (NAFLD)] or is a significant risk factor, such as reflux esophagitis and gallstones. When obesity is a risk factor, it may interact with other mechanisms and result in earlier presentation or complicated diseases. There are increased odds ratios or relative risks of several gastrointestinal complications of obesity: gastroesophageal reflux disease (GERD), erosive esophagitis, Barrett's esophagus, esophageal adenocarcinoma, erosive gastritis, gastric cancer, diarrhea, colonic diverticular disease, polyps, cancer, liver disease including NAFLD, cirrhosis, hepatocellular carcinoma, gallstones, acute pancreatitis, and pancreatic cancer...
February 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28191374/klebsiella-pneumoniae-liver-abscess-a-case-report-and-review-of-literature
#6
Faisal Kamal, George Williams, Hina Akbar, Muhammad Ali Khan, Dipen Kadaria
Klebsiella pneumoniae (K.pneumoniae) is a known cause of pyogenic liver abscess (PLA) in the absence of hepatobiliary disease. In settings of hepatic infection, it has also been known to cause disseminated infections including meningitis and endopthalmitis. Several groups of patients are particularly susceptible to infection, including patients with diabetes mellitus, those from Southeast Asia and those with the preexisting hepatobiliary disease. We present a case of K.pneumoniae PLA with bacteremia. A 39-year-old Vietnamese male with no previous medical history who presented with complaints of abdominal pain, nausea, vomiting, diarrhea and fever...
January 10, 2017: Curēus
https://www.readbyqxmd.com/read/28186546/case-control-assessment-of-the-roles-of-noroviruses-human-bocaviruses-2-3-and-4-and-novel-polyomaviruses-and-astroviruses-in-acute-childhood-diarrhea
#7
Rimma Melamed, Gregory A Storch, Lori R Holtz, Eileen J Klein, Brittany Herrin, Phillip I Tarr, Donna M Denno
No abstract text is available yet for this article.
February 10, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28183278/a-rare-case-of-renal-thrombotic-microangiopathy-associated-with-castleman-s-disease
#8
Anubha Mutneja, L Nicholas Cossey, Helen Liapis, Ying Maggie Chen
BACKGROUND: Castleman's disease (CD) is an uncommon, heterogeneous lympho-proliferative disorder leading to high circulating levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF). Renal involvement has been only described in a limited number of small studies. Herein, we report a rare case of renal thrombotic microangiopathy (TMA) associated with CD and investigate the podocyte expression of VEGF in the renal biopsy prior to initiation of treatment. CASE PRESENTATION: An 18-year-old male presented with fever, diarrhea, diffuse lymphadenopathy, ascites and acute kidney injury...
February 10, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28182338/evaluation-of-nested-polymerase-chain-reaction-and-immunoassay-for-rapid-diagnosis-of-clostridium-difficile-in-children-with-community-acquired-diarrhea
#9
Ahmed Elewa, Maysaa El Sayed-Zaki
BACKGROUND: Clostridium difficile (C. difficile) is a known pathogen associated with diarrhea especially in hospital acquired diarrhea. Yet, it is being recognized as a probable etiology for community acquired diarrhea. The aim of the present study was to detect the presence of C. difficile as a pathogen causing community acquired diarrhea in children and to verify the value of different laboratory methods for diagnosis, namely specific culture, immunoassay for toxin detection, and nested polymerase chain reaction (nested-PCR)...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28179321/efficacy-and-toxicity-of-induction-therapy-with-cladribine-idarubicin-and-cytarabine-iac-for-acute-myeloid-leukemia
#10
Susan K Woelich, James T Braun, Martin W Schoen, Reshma Ramlal, Carl E Freter, Paul J Petruska, Jack M Lionberger
We report our single-center experience with cytarabine and idarubicin for induction therapy for acute myeloid leukemia (AML) with an additional 5 days of cladribine (IAC therapy). From July 2012 to September 2014, 38 patients completed a full course of IAC induction. Median patient age was 61 years, 61% of patients were ≥60 years old, and 71% were male. The complete remission (CR) rate was 63% following a single induction course, three patients (8%) required a second induction course to achieve CR, for an overall response rate of 71%...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28177797/development-and-validation-of-a-quantitative-real-time-pcr-assay-for-sapovirus-in-under-five-year-old-children
#11
Massimiliano Bergallo, Ilaria Galliano, Paola Montanari, Martina Rosa Brusin, Serena Finotti, Giulia Paderi, Clara Gabiano
Gastroenteritis is a common disease in children, characterized by diarrhea, vomiting, abdominal pain, and fever. Sapovirus (SaV) is a causative agent of acute gastroenteritis although it causes milder illness than rotavirus and norovirus. There is high variability in analytical performance of quantitative PCR-based assays amongst clinical laboratories. This study develops a RT real-time PCR method to detect SaV in fecal specimens collected from under-five-year-old children with acute gastroenteritis. 15 out of 137 (10...
December 2, 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28176463/severe-chronic-norovirus-diarrheal-disease-in-transplant-recipients-clinical-features-of-an-under-recognized-syndrome
#12
Robin K Avery, Bonnie E Lonze, Edward S Kraus, Kieren A Marr, Robert A Montgomery
BACKGROUND: Norovirus (NV) infection has been reported as a cause of severe chronic diarrhea in transplant recipients, but this entity remains under-recognized in clinical practice, leading to diagnostic delays. Transplant clinicians should become familiar with this syndrome in order to facilitate early detection and management. METHODS: Demographic, clinical, and outcomes variables were summarized from a series of transplant recipients with positive stool NV reverse transcription polymerase chain reaction (RT-PCR) assays at Johns Hopkins in 2013-2014...
February 7, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28176232/celiac-disease-in-children-with-severe-acute-malnutrition-sam-a-hospital-based-study
#13
Neetu Beniwal, Gaurav Ameta, Chandra Kumar Chahar
OBJECTIVES: To evaluate the prevalence and clinical features of Celiac disease among children with severe acute malnutrition (SAM). METHODS: This prospective observational study was conducted in PBM Children Hospital, Bikaner from July 2012 through December 2013. All consecutively admitted children with SAM were recruited. All subjects were screened for Celiac disease by serological test for IgA-anti tissue Transglutaminase (IgA tTG) antibodies. All seropositive children underwent upper gastrointestinal endoscopy for small bowel biopsy for the confirmation...
February 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28167594/incidences-and-costs-of-illness-for-diarrhea-and-acute-respiratory-infections-for-children-5-years-of-age-in-rural-bangladesh
#14
Amal K Halder, Stephen P Luby, Shamima Akhter, Probir K Ghosh, Richard B Johnston, Leanne Unicomb
Understanding illness costs associated with diarrhea and acute respiratory infections (ARI) could guide prevention and treatment strategies. This study aimed to determine incidence of childhood diarrhea and ARI and costs of homecare, hospitalization, and outpatient treatment by practitioner type in rural Bangladesh. From each of 100 randomly selected population clusters we sampled 17 households with at least one child < 5 years of age. Childhood diarrhea incidence was 3,451 and ARI incidence was 5,849/1,000 child-years...
February 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28166712/experimental-acute-infection-of-alpacas-with-bovine-viral-diarrhea-virus-1-subgenotype-b-alters-peripheral-blood-and-galt-leukocyte-subsets
#15
Christina L Topliff, Abdulrahman A Alkheraif, Charles A Kuszynski, William C Davis, David J Steffen, Jack A Schmitz, Kent M Eskridge, Bryan Charleston, Jamie N Henningson, Clayton L Kelling
Bovine viral diarrhea virus (BVDV) is a pathogen in cattle and alpacas ( Vicugna pacos), causing acute and persistent BVDV infections. We characterized the effect of acute BVDV infection on the immune system of alpacas by determining lymphocyte subpopulations in peripheral blood and gut-associated lymphoid tissues (GALT) as well as serum interferon levels. Alpacas were experimentally infected with BVDV-1b (strain CO-06). Peripheral blood leukocytes were isolated at 0, 3, 6, and 9 d postinfection (dpi), and leukocytes of GALT at 9 dpi, and evaluated using flow cytometry...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28159230/goblet-cell-depletion-in-small-intestinal-villous-and-crypt-epithelium-of-conventional-nursing-and-weaned-pigs-infected-with-porcine-epidemic-diarrhea-virus
#16
Kwonil Jung, Linda J Saif
Intestinal goblet cells secret mucins to form mucus layers critical for maintaining the integrity of the intestinal epithelium. Porcine epidemic diarrhea virus (PEDV) causes watery diarrhea and high mortality of suckling pigs. PEDV mainly infects villous epithelial cells of the small intestine, and infected cells undergo acute, massive necrosis, followed by severe villous atrophy. Conventional 9-day-old nursing pigs [PEDV-inoculated (n=9); Mock (n=11)] and 26-day-old weaned [PEDV-inoculated (n=11); Mock (n=9)] were inoculated orally [8...
February 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28158186/a-high-throughput-phenotypic-screen-identifies-clofazimine-as-a-potential-treatment-for-cryptosporidiosis
#17
Melissa S Love, Federico C Beasley, Rajiv S Jumani, Timothy M Wright, Arnab K Chatterjee, Christopher D Huston, Peter G Schultz, Case W McNamara
Cryptosporidiosis has emerged as a leading cause of non-viral diarrhea in children under five years of age in the developing world, yet the current standard of care to treat Cryptosporidium infections, nitazoxanide, demonstrates limited and immune-dependent efficacy. Given the lack of treatments with universal efficacy, drug discovery efforts against cryptosporidiosis are necessary to find therapeutics more efficacious than the standard of care. To date, cryptosporidiosis drug discovery efforts have been limited to a few targeted mechanisms in the parasite and whole cell phenotypic screens against small, focused collections of compounds...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28154090/repeated-fecal-microbiota-transplantations-attenuate-diarrhea-and-lead-to-sustained-changes-in-the-fecal-microbiota-in-acute-refractory-gastrointestinal-graft-versus-host-disease
#18
Walter Spindelboeck, Eduard Schulz, Barbara Uhl, Karl Kashofer, Ariane Aigelsreiter, Wilma Zinke-Cerwenka, Adnan Mulabecirovic, Patrizia K Kump, Bettina Halwachs, Gregor Gorkiewicz, Heinz Sill, Hildegard Greinix, Christoph Högenauer, Peter Neumeister
No abstract text is available yet for this article.
February 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28152538/two-cases-of-mistaken-polyuria-and-nephrocalcinosis-in-infants-with-glucose-galactose-malabsorption-a-possible-role-of-1-25-oh-2d3%C3%A2
#19
Melissa Fiscaletti, Marie-Jeanne Lebel, Nathalie Alos, Geneviève Benoit, Prévost Jantchou
BACKGROUND/AIMS: Glucose-galactose malabsorption (GGM) is a rare and potentially fatal disorder. The autosomal recessive mutation of the SGLT1 gene interferes with the active glucose transport in the gut resulting in osmotic diarrhea and failure to thrive (FTT). Two nonrelated infants with GGM are presented as well as a novel mutation in SGLT1. CASE PRESENTATION: The first case consulted for FTT and presented with hypercalcemia and hypercalciuria. His mother had self-medicated with high doses of vitamin D...
February 2, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28151511/-economic-impact-of-afid-management-with-modern-management-system-in-intensive-care-patients-comparison-between-icus
#20
Giovanni Fuoco, Paola Di Giulio
: . Economic impact of AFId management with modern management systems in Intensive Care patients: comparison between ICUs. INTRODUCTION: Acute fecal incontinence associated with diarrhea (AFId) affects up to 40% of intensive care unit (ICU) patients and may be responsible for pressure ulcers (PU). The FMS (Fecal Management System) though improving the management of these patients is not often provided due to its cost. AIM: To measure the costs of the use of FMS compared to routine care in three intensive care units (ICU) of Piedmont (Italy)...
October 2016: Assistenza Infermieristica e Ricerca: AIR
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