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arterial wall thickness, ultrasound

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https://www.readbyqxmd.com/read/27857821/carotid-artery-atherosclerosis-in-patients-with-active-rheumatoid-arthritis-predictors-of-plaque-occurrence-and-progression-over-24-weeks
#1
Janet E Pope, Tatiana Nevskaya, Lillian Barra, Grace Parraga
INTRODUCTION: This study evaluated the prevalence and progression of subclinical carotid artery atherosclerosis in active rheumatoid arthritis (RA). METHODS: Carotid arteries of RA patients were scanned using 3D ultrasound at baseline and 24 weeks for total plaque area, vessel wall volume, and intima-media thickness (IMT), as well as arterial stiffness measured using pulse wave velocity. Variables related to inflammation, lipids and cardiovascular (CV) risk were assessed for associations with plaque progression...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27846838/effects-of-shenlian-extract-on-experimental-atherosclerosis-in-apoe-deficient-mice-based-on-ultrasound-biomicroscopy
#2
Yan Guo, Xu-Cen Liu, Ya-Jie Wang, Qi Li, Qing Yang, Xiao-Gang Weng, Ying Chen, Wei-Yan Cai, Xiao-Xi Kan, Xi Chen, He-Fei Huang, Xiao-Xin Zhu, Yu-Jie Li
BACKGROUND: This study directly and dynamically investigated the effects of SL extract (i.e., a combination of Radix Salviae miltiorrhizae and Andrographis paniculata extract) on plaque progression in vivo by high resolution ultrasound biomicroscopy (UBM). METHODS: An atherosclerosis model was established by placing a perivascular collar on the right common carotid artery in apolipoprotein E-deficient (ApoE(-/-)) mice. Thickness, plaque area and local blood flow were observed by UBM, pathological changes were observed by histochemical staining, and lipid levels were measured by respective commercially available kits...
November 15, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27830569/a-review-on-atherosclerotic-biology-wall-stiffness-physics-of-elasticity-and-its-ultrasound-based-measurement
#3
REVIEW
Anoop K Patel, Harman S Suri, Jaskaran Singh, Dinesh Kumar, Shoaib Shafique, Andrew Nicolaides, Sanjay K Jain, Luca Saba, Ajay Gupta, John R Laird, Argiris Giannopoulos, Jasjit S Suri
Functional and structural changes in the common carotid artery are biomarkers for cardiovascular risk. Current methods for measuring functional changes include pulse wave velocity, compliance, distensibility, strain, stress, stiffness, and elasticity derived from arterial waveforms. The review is focused on the ultrasound-based carotid artery elasticity and stiffness measurements covering the physics of elasticity and linking it to biological evolution of arterial stiffness. The paper also presents evolution of plaque with a focus on the pathophysiologic cascade leading to arterial hardening...
December 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27810621/concise-biomarker-for-spatial-temporal-change-in-three-dimensional-ultrasound-measurement-of-carotid-vessel-wall-and-plaque-thickness-based-on-a-graph-based-random-walk-framework-towards-sensitive-evaluation-of-response-to-therapy
#4
Bernard Chiu, Weifu Chen, Jieyu Cheng
Rapid progression in total plaque area and volume measured from ultrasound images has been shown to be associated with an elevated risk of cardiovascular events. Since atherosclerosis is focal and predominantly occurring at the bifurcation, biomarkers that are able to quantify the spatial distribution of vessel-wall-plus-plaque thickness (VWT) change may allow for more sensitive detection of treatment effect. The goal of this paper is to develop simple and sensitive biomarkers to quantify the responsiveness to therapies based on the spatial distribution of VWT-Change on the entire 2D carotid standardized map previously described...
October 19, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27794213/the-relationship-between-the-metabolic-syndrome-and-arterial-wall-thickness-a-mosaic-still-to-be-interpreted
#5
Angelo Scuteri, Oscar H Franco, Henry Völzke, Min-Ho Shin, Sun-Seog Kweon, Ernst Rietzschel, Ligita Ryliškytė, Irina Strazhesko, Chen-Huan Chen, Edward G Lakatta, Peter M Nilsson
BACKGROUND AND AIMS: We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. METHODS: We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. RESULTS: Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50-90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL cholesterol, and presence of diabetes mellitus...
October 15, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27780271/quantification-of-coupled-stiffness-and-fiber-orientation-remodeling-in-hypertensive-rat-right-ventricular-myocardium-using-3d-ultrasound-speckle-tracking-with-biaxial-testing
#6
Dae Woo Park, Andrea Sebastiani, Choon Hwai Yap, Marc A Simon, Kang Kim
Mechanical and structural changes of right ventricular (RV) in response to pulmonary hypertension (PH) are inadequately understood. While current standard biaxial testing provides information on the mechanical behavior of RV tissues using surface markers, it is unable to fully assess structural and mechanical properties across the full tissue thickness. In this study, the mechanical and structural properties of normotensive and pulmonary hypertension right ventricular (PHRV) myocardium through its full thickness were examined using mechanical testing combined with 3D ultrasound speckle tracking (3D-UST)...
2016: PloS One
https://www.readbyqxmd.com/read/27753967/os-10-06-the-impact-of-well-controlled-blood-pressure-levels-on-arterial-properties-in-essential-hypertensives
#7
Paolo Pauletto, Massimo Puato, Marcello Rattazzi, Roberta Buso, Giovanni Boschetti, Marta Zanon, Claudio Fania, Paolo Palatini
OBJECTIVE: The aim of this study was to evaluate the impact of well controlled blood pressure (BP) levels on structural and functional properties of arteries in essential hypertensives. DESIGN AND METHOD: We studied 80 young hypertensives (mean age 49 yo) allocated either to pharmacological treatment (55 of 80) or to lifestyle modifications (25 of 80) for at least 12 months (mean 38 months) to maintain target BP. Follow-up visits were scheduled every 6 months. Office BP was taken three times by the same doctor at the time of the study...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27742139/a-fully-automatic-method-to-segment-the-carotid-artery-layers%C3%A2-in-ultrasound-imaging-application-to-quantify-the%C3%A2-compression-decompression-pattern-of-the-intima-media-complex-during-the-cardiac-cycle
#8
Guillaume Zahnd, Kostas Kapellas, Martijn van Hattem, Anouk van Dijk, André Sérusclat, Philippe Moulin, Aad van der Lugt, Michael Skilton, Maciej Orkisz
The aim of this study was to introduce and evaluate a contour segmentation method to extract the interfaces of the intima-media complex in carotid B-mode ultrasound images. The method was applied to assess the temporal variation of intima-media thickness during the cardiac cycle. The main methodological contribution of the proposed approach is the introduction of an augmented dimension to process 2-D images in a 3-D space. The third dimension, which is added to the two spatial dimensions of the image, corresponds to the tentative local thickness of the intima-media complex...
October 12, 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27741977/carotid-intima-media-thickness-as-surrogate-for-and-predictor-of-cvd
#9
Joseph F Polak, Daniel H O'Leary
Carotid artery intima-media thickness (IMT) is a noninvasive measurement of the artery wall thickness, inclusive of atherosclerotic plaque, obtained using ultrasound imaging. In the MESA (Multi-Ethnic Study of Atherosclerosis) study, IMT measurements are used as a surrogate for subclinical cardiovascular disease and as a variable predictive of cardiovascular events. IMT measurements of the common carotid artery are available in more than 99% of the MESA population and are predictive of cardiovascular events...
September 2016: Global Heart
https://www.readbyqxmd.com/read/27725195/cardiovascular-health-effects-of-oral-and-pulmonary-exposure-to-multi-walled-carbon-nanotubes-in-apoe-deficient-mice
#10
Daniel V Christophersen, Nicklas R Jacobsen, Maria H G Andersen, Shea P Connell, Kenneth K Barfod, Morten B Thomsen, Mark R Miller, Rodger Duffin, Jens Lykkesfeldt, Ulla Vogel, Håkan Wallin, Steffen Loft, Martin Roursgaard, Peter Møller
Exposure to high aspect ratio nanomaterials, such as multi-walled carbon nanotubes (MWCNTs) may be associated with increased risk of atherosclerosis, pulmonary disease, and cancer. In the present study, we investigated the cardiovascular and pulmonary health effects of 10 weeks of repeated oral or pulmonary exposures to MWCNTs (4 or 40μg each week) in Apolipoprotein E-deficient (ApoE(-/-)) mice fed a Western-type diet. Intratracheal instillation of MWCNTs was associated with oxidative damage to DNA in lung tissue and elevated levels of lipid peroxidation products in plasma, whereas the exposure only caused a modest pulmonary inflammation in terms of increased numbers of lymphocytes in bronchoalveolar lavage fluid...
October 8, 2016: Toxicology
https://www.readbyqxmd.com/read/27686104/validation-of-noninvasive-in-vivo-compound-ultrasound-strain-imaging-using-histologic-plaque-vulnerability-features
#11
Hendrik H G Hansen, Gert Jan de Borst, Michiel L Bots, Frans L Moll, Gerard Pasterkamp, Chris L de Korte
BACKGROUND AND PURPOSE: Carotid plaque rupture is a major cause of stroke. Key issue for risk stratification is early identification of rupture-prone plaques. A noninvasive technique, compound ultrasound strain imaging, was developed providing high-resolution radial deformation/strain images of atherosclerotic plaques. This study aims at in vivo validation of compound ultrasound strain imaging in patients by relating the measured strains to typical features of vulnerable plaques derived from histology after carotid endarterectomy...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27643364/os-10-06-the-impact-of-well-controlled-blood-pressure-levels-on-arterial-properties-in-essential-hypertensives
#12
Paolo Pauletto, Massimo Puato, Marcello Rattazzi, Roberta Buso, Giovanni Boschetti, Marta Zanon, Claudio Fania, Paolo Palatini
OBJECTIVE: The aim of this study was to evaluate the impact of well controlled blood pressure (BP) levels on structural and functional properties of arteries in essential hypertensives. DESIGN AND METHOD: We studied 80 young hypertensives (mean age 49 yo) allocated either to pharmacological treatment (55 of 80) or to lifestyle modifications (25 of 80) for at least 12 months (mean 38 months) to maintain target BP. Follow-up visits were scheduled every 6 months. Office BP was taken three times by the same doctor at the time of the study...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27627559/the-relationship-of-carotid-arterial-stiffness-and-left-ventricular-concentric-hypertrophy-in-hypertension
#13
Joanna Jaroch, Krystyna Łoboz-Grudzień, Stefania Magda, Maria Florescu, Zbigniew Bociąga, Andrea O Ciobanu, Ewa Kruszyńska, Krzysztof Dudek, Dragos Vinereanu
BACKGROUND: Left ventricular hypertrophy (LVH) and geometry patterns vary in different hemodynamic profiles The concentric hypertrophy (CH) pattern has been proved to have the worst prognosis. OBJECTIVES: The aim of the study was to test the hypothesis that carotid artery stiffness, as a marker of vascular damage, is associated with CH, independently of other potential determinants such as demographic factors (age, sex, BMI), clinical parameters (smoking, diabetes, creatinine level) and hemodynamic variables (blood pressure, pulse pressure [PP])...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27613385/assessment-of-epicardial-adipose-tissue-and-carotid-femoral-intima-media-thickness-in-insulin-resistance
#14
Cihan Altin, Leyla Elif Sade, Esin Gezmis, Mustafa Yilmaz, Necmi Ozen, Haldun Muderrisoglu
BACKGROUND: Metabolic syndrome is a combination of multiple cardiovascular (CV) risk factors including insulin resistance (IR). Carotid, femoral intima media thickness (IMT), and epicardial fat thickness (EFT) are considered as novel cardiometabolic risk factors. We aimed to test the hypothesis that carotid, femoral IMT, and EFT are increased in patients with IR. METHODS: We enrolled consecutively and prospectively 113 patients with IR. Then we collected data from an age- and sex-matched control group of 112 individuals without IR...
September 6, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27601367/neonatal-arterial-morphology-is-related-to-body-size-in-abnormal-human-fetal-growth
#15
Rasmus F W Olander, Johnny K M Sundholm, Tiina H Ojala, Sture Andersson, Taisto Sarkola
BACKGROUND: Restriction in fetal growth is associated with cardiovascular disease in adulthood. It is unclear whether abnormal intrauterine growth influences arterial morphology during the fetal or neonatal stage. The objective was to study the regional arterial morphology with respect to gestational age and abnormal fetal body size. METHODS AND RESULTS: We studied body anthropometrics and arterial morphology and physiology in 174 neonates born between 31 and 42 weeks of gestation, including neonates with birth weights appropriate, small, and large for age, with very high resolution vascular ultrasound (35-55 MHz)...
September 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27533954/effect-of-inter-individual-blood-pressure-variability-on-the-progression-of-atherosclerosis-in-carotid-and-coronary-arteries-a-post-hoc-analysis-of-the-normalise-and-prevent-studies
#16
Jung-Sun Kim, Sungha Park, Ping Yan, Barrett W Jeffers, César Cerezo
AIMS: To investigate the relationship between visit-to-visit BPV and the progression of both carotid and coronary artery disease (CAD). METHODS AND RESULTS: Data from two cardiovascular endpoint studies (NORMALISE and PREVENT) were analyzed separately. Systolic BPV was assessed as within-subject standard deviation (SD) of systolic BP across visits from 12-weeks onwards. Follow-up was 24-months (NORMALISE) or 36-months (PREVENT). Any association between BPV and progression of atherosclerosis was assessed using quantitative coronary angiography (QCA), intravascular ultrasound (IVUS), or B-mode ultrasound (depending on study)...
August 5, 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/27508805/-op-1c-04-structural-and-functional-arterial-abnormalities-in-fibromuscular-dysplasia-are-in-the-continuum-of-hypertension-an-imaging-and-biomechanical-study
#17
L Marais, P Boutouyrie, H Khettab, C Boulanger, A Lorthiroir, M Frank, R Niarra, J Renard, Y Chambon, X Jeunemaitre, M Zidi, P-F Plouin, S Laurent, M Azizi
OBJECTIVE: Fibromuscular dysplasia (FMD) is a non-atherosclerotic non-inflammatory arterial disease, which occurs mostly in middle-aged women and affects medium-sized arteries. We previously showed abnormalities within common carotid artery (CCA) wall, with the presence of triple signal (TS) at ultrasound suggesting the presence of supplementary layers. We aimed at coupling TS presence with microconstituents of the vessel wall, derived from fitting of the pressure-diameter curve. DESIGN AND METHOD: We included 50 non-smoking patients with multifocal FMD, 50 essential hypertensive (EH) patients and 50 healthy subjects (HS) matched for age, sex, ethnicity and BP (EH and FD)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27504830/a-family-history-of-stroke-is-associated-with-increased-intima-media-thickness-in-young-ischemic-stroke-the-norwegian-stroke-in-the-young-study-nor-sys
#18
Halvor Øygarden, Annette Fromm, Kristin Modalsli Sand, Christopher Elnan Kvistad, Geir Egil Eide, Lars Thomassen, Halvor Naess, Ulrike Waje-Andreassen
BACKGROUND AND PURPOSE: Positive family history (FH+) of cardiovascular disease (CVD) is a risk factor for own CVD. We aimed to analyze the effect of different types of FH (stroke, coronary heart disease (CHD), peripheral artery disease (PAD) on carotid intima-media thickness (cIMT) in young and middle-aged ischemic stroke patients. METHODS: First-degree FH of CVD was assessed in ischemic stroke patients ≤ 60y using a standardized interview. Carotid ultrasound was performed and far wall cIMT in three carotid artery segments was registered, representing the common carotid (CCA-IMT), carotid bifurcation (BIF-IMT) and the internal carotid artery (ICA-IMT)...
2016: PloS One
https://www.readbyqxmd.com/read/27486794/high-spatial-inhomogeneity-in-the-intima-media-thickness-of-the-common-carotid-artery-is-associated-with-a-larger-degree-of-stenosis-in-the-internal-carotid-artery-the-parisk-study
#19
J Steinbuch, A C van Dijk, F H B M Schreuder, M T B Truijman, A A J de Rotte, P J Nederkoorn, A van der Lugt, E Hermeling, A P G Hoeks, W H Mess
Purpose: Inhomogeneity of arterial wall thickness may be indicative of distal plaques. This study investigates the intra-subject association between relative spatial intima-media thickness (IMT) inhomogeneity of the common carotid artery (CCA) and the degree of stenosis of plaques in the internal carotid artery (ICA). Materials and Methods: We included 240 patients with a recent ischemic stroke or transient ischemic attack and mild-to-moderate stenosis in the ipsilateral ICA. IMT inhomogeneity was extracted from B-mode ultrasound recordings...
August 3, 2016: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/27467821/tissue-engineered-small-diameter-arterial-vascular-grafts-from-cell-free-nanofiber-pcl-chitosan-scaffolds-in-a-sheep-model
#20
Takuma Fukunishi, Cameron A Best, Tadahisa Sugiura, Toshihiro Shoji, Tai Yi, Brooks Udelsman, Devan Ohst, Chin Siang Ong, Huaitao Zhang, Toshiharu Shinoka, Christopher K Breuer, Jed Johnson, Narutoshi Hibino
Tissue engineered vascular grafts (TEVGs) have the potential to overcome the issues faced by existing small diameter prosthetic grafts by providing a biodegradable scaffold where the patient's own cells can engraft and form functional neotissue. However, applying classical approaches to create arterial TEVGs using slow degrading materials with supraphysiological mechanical properties, typically results in limited host cell infiltration, poor remodeling, stenosis, and calcification. The purpose of this study is to evaluate the feasibility of novel small diameter arterial TEVGs created using fast degrading material...
2016: PloS One
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