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arterial wall thickness, ultrasound

Paolo Pauletto, Massimo Puato, Marcello Rattazzi, Roberta Buso, Giovanni Boschetti, Marta Zanon, Claudio Fania, Paolo Palatini
OBJECTIVE: The aim of this study was to evaluate the impact of well controlled blood pressure (BP) levels on structural and functional properties of arteries in essential hypertensives. DESIGN AND METHOD: We studied 80 young hypertensives (mean age 49 yo) allocated either to pharmacological treatment (55 of 80) or to lifestyle modifications (25 of 80) for at least 12 months (mean 38 months) to maintain target BP. Follow-up visits were scheduled every 6 months. Office BP was taken three times by the same doctor at the time of the study...
September 2016: Journal of Hypertension
Guillaume Zahnd, Kostas Kapellas, Martijn van Hattem, Anouk van Dijk, André Sérusclat, Philippe Moulin, Aad van der Lugt, Michael Skilton, Maciej Orkisz
The aim of this study was to introduce and evaluate a contour segmentation method to extract the interfaces of the intima-media complex in carotid B-mode ultrasound images. The method was applied to assess the temporal variation of intima-media thickness during the cardiac cycle. The main methodological contribution of the proposed approach is the introduction of an augmented dimension to process 2-D images in a 3-D space. The third dimension, which is added to the two spatial dimensions of the image, corresponds to the tentative local thickness of the intima-media complex...
October 12, 2016: Ultrasound in Medicine & Biology
Joseph F Polak, Daniel H O'Leary
Carotid artery intima-media thickness (IMT) is a noninvasive measurement of the artery wall thickness, inclusive of atherosclerotic plaque, obtained using ultrasound imaging. In the MESA (Multi-Ethnic Study of Atherosclerosis) study, IMT measurements are used as a surrogate for subclinical cardiovascular disease and as a variable predictive of cardiovascular events. IMT measurements of the common carotid artery are available in more than 99% of the MESA population and are predictive of cardiovascular events...
September 2016: Global Heart
Daniel V Christophersen, Nicklas R Jacobsen, Maria H G Andersen, Shea P Connell, Kenneth K Barfod, Morten B Thomsen, Mark R Miller, Rodger Duffin, Jens Lykkesfeldt, Ulla Vogel, Håkan Wallin, Steffen Loft, Martin Roursgaard, Peter Møller
Exposure to high aspect ratio nanomaterials, such as multi-walled carbon nanotubes (MWCNTs) may be associated with increased risk of atherosclerosis, pulmonary disease, and cancer. In the present study, we investigated the cardiovascular and pulmonary health effects of 10 weeks of repeated oral or pulmonary exposures to MWCNTs (4 or 40μg each week) in Apolipoprotein E-deficient (ApoE(-/-)) mice fed a Western-type diet. Intratracheal instillation of MWCNTs was associated with oxidative damage to DNA in lung tissue and elevated levels of lipid peroxidation products in plasma, whereas the exposure only caused a modest pulmonary inflammation in terms of increased numbers of lymphocytes in bronchoalveolar lavage fluid...
October 7, 2016: Toxicology
Hendrik H G Hansen, Gert Jan de Borst, Michiel L Bots, Frans L Moll, Gerard Pasterkamp, Chris L de Korte
BACKGROUND AND PURPOSE: Carotid plaque rupture is a major cause of stroke. Key issue for risk stratification is early identification of rupture-prone plaques. A noninvasive technique, compound ultrasound strain imaging, was developed providing high-resolution radial deformation/strain images of atherosclerotic plaques. This study aims at in vivo validation of compound ultrasound strain imaging in patients by relating the measured strains to typical features of vulnerable plaques derived from histology after carotid endarterectomy...
September 29, 2016: Stroke; a Journal of Cerebral Circulation
Paolo Pauletto, Massimo Puato, Marcello Rattazzi, Roberta Buso, Giovanni Boschetti, Marta Zanon, Claudio Fania, Paolo Palatini
OBJECTIVE: The aim of this study was to evaluate the impact of well controlled blood pressure (BP) levels on structural and functional properties of arteries in essential hypertensives. DESIGN AND METHOD: We studied 80 young hypertensives (mean age 49 yo) allocated either to pharmacological treatment (55 of 80) or to lifestyle modifications (25 of 80) for at least 12 months (mean 38 months) to maintain target BP. Follow-up visits were scheduled every 6 months. Office BP was taken three times by the same doctor at the time of the study...
September 2016: Journal of Hypertension
Joanna Jaroch, Krystyna Łoboz-Grudzień, Stefania Magda, Maria Florescu, Zbigniew Bociąga, Andrea O Ciobanu, Ewa Kruszyńska, Krzysztof Dudek, Dragos Vinereanu
BACKGROUND: Left ventricular hypertrophy (LVH) and geometry patterns vary in different hemodynamic profiles The concentric hypertrophy (CH) pattern has been proved to have the worst prognosis. OBJECTIVES: The aim of the study was to test the hypothesis that carotid artery stiffness, as a marker of vascular damage, is associated with CH, independently of other potential determinants such as demographic factors (age, sex, BMI), clinical parameters (smoking, diabetes, creatinine level) and hemodynamic variables (blood pressure, pulse pressure [PP])...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Cihan Altin, Leyla Elif Sade, Esin Gezmis, Mustafa Yilmaz, Necmi Ozen, Haldun Muderrisoglu
BACKGROUND: Metabolic syndrome is a combination of multiple cardiovascular (CV) risk factors including insulin resistance (IR). Carotid, femoral intima media thickness (IMT), and epicardial fat thickness (EFT) are considered as novel cardiometabolic risk factors. We aimed to test the hypothesis that carotid, femoral IMT, and EFT are increased in patients with IR. METHODS: We enrolled consecutively and prospectively 113 patients with IR. Then we collected data from an age- and sex-matched control group of 112 individuals without IR...
September 6, 2016: Journal of Cardiology
Rasmus F W Olander, Johnny K M Sundholm, Tiina H Ojala, Sture Andersson, Taisto Sarkola
BACKGROUND: Restriction in fetal growth is associated with cardiovascular disease in adulthood. It is unclear whether abnormal intrauterine growth influences arterial morphology during the fetal or neonatal stage. The objective was to study the regional arterial morphology with respect to gestational age and abnormal fetal body size. METHODS AND RESULTS: We studied body anthropometrics and arterial morphology and physiology in 174 neonates born between 31 and 42 weeks of gestation, including neonates with birth weights appropriate, small, and large for age, with very high resolution vascular ultrasound (35-55 MHz)...
September 2016: Circulation. Cardiovascular Imaging
Jung-Sun Kim, Sungha Park, Ping Yan, Barrett W Jeffers, César Cerezo
AIMS: To investigate the relationship between visit-to-visit BPV and the progression of both carotid and coronary artery disease (CAD). METHODS AND RESULTS: Data from two cardiovascular endpoint studies (NORMALISE and PREVENT) were analyzed separately. Systolic BPV was assessed as within-subject standard deviation (SD) of systolic BP across visits from 12-weeks onwards. Follow-up was 24-months (NORMALISE) or 36-months (PREVENT). Any association between BPV and progression of atherosclerosis was assessed using quantitative coronary angiography (QCA), intravascular ultrasound (IVUS), or B-mode ultrasound (depending on study)...
August 5, 2016: European Heart Journal. Cardiovascular Pharmacotherapy
L Marais, P Boutouyrie, H Khettab, C Boulanger, A Lorthiroir, M Frank, R Niarra, J Renard, Y Chambon, X Jeunemaitre, M Zidi, P-F Plouin, S Laurent, M Azizi
OBJECTIVE: Fibromuscular dysplasia (FMD) is a non-atherosclerotic non-inflammatory arterial disease, which occurs mostly in middle-aged women and affects medium-sized arteries. We previously showed abnormalities within common carotid artery (CCA) wall, with the presence of triple signal (TS) at ultrasound suggesting the presence of supplementary layers. We aimed at coupling TS presence with microconstituents of the vessel wall, derived from fitting of the pressure-diameter curve. DESIGN AND METHOD: We included 50 non-smoking patients with multifocal FMD, 50 essential hypertensive (EH) patients and 50 healthy subjects (HS) matched for age, sex, ethnicity and BP (EH and FD)...
September 2016: Journal of Hypertension
Halvor Øygarden, Annette Fromm, Kristin Modalsli Sand, Christopher Elnan Kvistad, Geir Egil Eide, Lars Thomassen, Halvor Naess, Ulrike Waje-Andreassen
BACKGROUND AND PURPOSE: Positive family history (FH+) of cardiovascular disease (CVD) is a risk factor for own CVD. We aimed to analyze the effect of different types of FH (stroke, coronary heart disease (CHD), peripheral artery disease (PAD) on carotid intima-media thickness (cIMT) in young and middle-aged ischemic stroke patients. METHODS: First-degree FH of CVD was assessed in ischemic stroke patients ≤ 60y using a standardized interview. Carotid ultrasound was performed and far wall cIMT in three carotid artery segments was registered, representing the common carotid (CCA-IMT), carotid bifurcation (BIF-IMT) and the internal carotid artery (ICA-IMT)...
2016: PloS One
J Steinbuch, A C van Dijk, F H B M Schreuder, M T B Truijman, A A J de Rotte, P J Nederkoorn, A van der Lugt, E Hermeling, A P G Hoeks, W H Mess
Purpose: Inhomogeneity of arterial wall thickness may be indicative of distal plaques. This study investigates the intra-subject association between relative spatial intima-media thickness (IMT) inhomogeneity of the common carotid artery (CCA) and the degree of stenosis of plaques in the internal carotid artery (ICA). Materials and Methods: We included 240 patients with a recent ischemic stroke or transient ischemic attack and mild-to-moderate stenosis in the ipsilateral ICA. IMT inhomogeneity was extracted from B-mode ultrasound recordings...
August 3, 2016: Ultraschall in der Medizin
Takuma Fukunishi, Cameron A Best, Tadahisa Sugiura, Toshihiro Shoji, Tai Yi, Brooks Udelsman, Devan Ohst, Chin Siang Ong, Huaitao Zhang, Toshiharu Shinoka, Christopher K Breuer, Jed Johnson, Narutoshi Hibino
Tissue engineered vascular grafts (TEVGs) have the potential to overcome the issues faced by existing small diameter prosthetic grafts by providing a biodegradable scaffold where the patient's own cells can engraft and form functional neotissue. However, applying classical approaches to create arterial TEVGs using slow degrading materials with supraphysiological mechanical properties, typically results in limited host cell infiltration, poor remodeling, stenosis, and calcification. The purpose of this study is to evaluate the feasibility of novel small diameter arterial TEVGs created using fast degrading material...
2016: PloS One
Jang-Ho Bae, Wuon-Shik Kim, Moo-Sik Lee, Kee-Sik Kim, Jeong Bae Park, Ho-Joong Youn, Chang-Gyu Park, Kyung-Soon Hong, Jang-Young Kim, Jin-Won Jeong, Jong Chun Park, Do-Sun Lim, Moo Hyun Kim, Jeong Taek Woo
AIM: It is still unclear which layer (intima or media) is mainly involved in increased carotid intima-media thickness (CIMT) by aging and also unclear regarding CIMT value suggesting high cardiovascular risk, although 75(th) percentile value of CIMT is known as a high risk in asymptomatic adults. We sought to find the changes of carotid intima thickness (CIT) and carotid media thickness (CMT) by aging and the 75(th) percentile value of CIMT in asymptomatic Korean adults. METHOD: This is an observational cohort study...
July 15, 2016: Cardiovascular Therapeutics
Dorothy M Gujral, Wing Keung Cheung, Benoy N Shah, Navtej S Chahal, Sanjeev Bhattacharyya, James Hooper, Roxy Senior, Meng-Xing Tang, Kevin J Harrington, Christopher M Nutting
PURPOSE: Abnormal proliferation of adventitial vasa vasorum (vv) occurs early at sites of atherosclerosis and is thought to be an early biomarker of vascular damage. Contrast-enhanced ultrasound (CEUS) can detect this process. Its usefulness in irradiated arteries as a measure of accelerated atherosclerosis is unknown. This study investigates contrast intensity in carotid adventitia as an early marker of radiation-induced damage in head and neck cancer (HNC) patients. MATERIALS/METHODS: Patients with HNC treated with a wedged-pair and matched neck technique or hemi-neck radiotherapy (RT) (unirradiated side as control) at least 2years previously were included...
July 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Denisa Salihović Hajdarević, Aleksandra M Pavlović, Dzevdet Smajlović, Ana Podgorac, Zagorka Jovanović, Tamara Svabić Medjedović, Nadezda Covicković Sternić
INTRODUCTION: Cerebral ischemic small-vessel disease (SVD), causing lacunar infarcts and white matter hyperintensities on brain magnetic resonance imaging (MRI), is a progressive disease associated with an increased risk of stroke, dementia and death. Increased arterial stiffness has been associated with ischemic stroke and cerebral SVD independently of common vascular risk factors. OBJECTIVE: The aim of the study was to analyze arterial stiffness in our patients with symptomatic SVD...
January 2016: Srpski Arhiv za Celokupno Lekarstvo
A Tuenter, M Selwaness, A Arias Lorza, J C H Schuurbiers, L Speelman, M Cibis, A van der Lugt, M de Bruijne, A F W van der Steen, O H Franco, M W Vernooij, J J Wentzel
BACKGROUND AND AIMS: Carotid artery plaques with vulnerable plaque components are related to a higher risk of cerebrovascular accidents. It is unknown which factors drive vulnerable plaque development. Shear stress, the frictional force of blood at the vessel wall, is known to influence plaque formation. We evaluated the association between shear stress and plaque components (intraplaque haemorrhage (IPH), lipid rich necrotic core (LRNC) and/or calcifications) in relatively small carotid artery plaques in asymptomatic persons...
August 2016: Atherosclerosis
Chris L de Korte, Stein Fekkes, Aart J Nederveen, Rashindra Manniesing, Hendrik Rik H G Hansen
Cardiovascular disease (CVD) is a leading cause of death and is in the majority of cases due to the formation of atherosclerotic plaques in arteries. Initially, thickening of the inner layer of the arterial wall occurs. Continuation of this process leads to plaque formation. The risk of a plaque to rupture and thus to induce an ischemic event is directly related to its composition. Consequently, characterization of the plaque composition and its proneness to rupture are of crucial importance for risk assessment and treatment strategies...
October 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Betul Sereflican, Betul Kizildag, Sıddıka Halicioglu, Nadir Goksugur, Bengu Tuman, Emine Dagistan
OBJECTIVES: Chronic inflammation and endothelial dysfunction are the characteristic features of Behçet's disease (BD). We researched carotid extra-medial thickness (cEMT), a novel ultrasound parameter for atherosclerotic vessel wall changes, and carotid intima media thickness (cIMT), a widely accepted marker of subclinical atherosclerosis, in patients with BD, and we evaluated the relationship between these two parameters. MATERIALS AND METHODS: In total, 31 patients with BD were matched to 26 control subjects based on age, gender, and major cardiovascular risk factors...
October 2016: International Journal of Dermatology
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