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https://www.readbyqxmd.com/read/29428163/from-neutral-to-zwitterionic-poly-%C3%AE-amino-acid-nonfouling-surfaces-effects-of-helical-conformation-and-anchoring-orientation
#1
Chong Zhang, Jingsong Yuan, Jianhua Lu, Yingqin Hou, Wei Xiong, Hua Lu
The development of high-performance nonfouling polymer surfaces for implantable medical devices and therapeutic nanomaterials is of great importance. Elaborating the relationship of polymer structural characteristics and the resulted surface properties can offer useful guidance toward ideal biointerfaces. In this work, we investigate the effects of the helical conformation and anchoring orientation of poly(α-amino acid)s (PαAAs) to produce advanced nonfouling surfaces. By using the neutral poly(γ-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)esteryl glutamates) (P(EG3Glu)s) as a model system, the adsorption kinetics are monitored by ex-situ variable angle spectroscopic ellipsometry and in-situ quartz crystal microbalance with dissipation...
February 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29318876/on-demand-modulation-of-bacterial-cell-fates-on-multifunctional-dynamic-substrates
#2
Inseong Choi, Jinhwan Lee, Wontae Kim, Hyunook Kang, Se Won Bae, Rakwoo Chang, Sunghyun Kim, Woon-Seok Yeo
This paper reports unprecedented dynamic surfaces based on zwitterionic low density self-assembled monolayers (LDSAMs) of alkanethiolates on gold, which integrate three interconvertible states - bacteria-adherable, bactericidal, and nonfouling states - through electrical modulations. The conformations of alkanethiolates were electrically modulated to generate zwitterionic, anionic, and cationic surfaces, which responded differently to bacteria and determined the fate of bacteria. Furthermore, the reversible switching of multi-functions of the surface was realized for killing bacteria and subsequently releasing dead bacteria from the surface...
January 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29231737/stability-of-polyethylene-glycol-and-zwitterionic-surface-modifications-in-pdms-microfluidic-flow-chambers
#3
Thomas James Plegue, Kyle M Kovach, Alex J Thompson, Joseph A Potkay
Blood-material interactions are crucial to the lifetime, safety, and overall success of a blood contacting devices. Hydrophilic polymer coatings have been employed to improve device lifetime by shielding blood contacting materials from the natural foreign body response, primarily the intrinsic pathway of the coagulation cascade. These coatings have the ability to repel proteins, cells, bacteria, and other micro-organisms. Coatings are desired to have long-term stability, so that the nonthrombogenic and nonfouling effects gained are long lasting...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29166921/identification-of-epidermal-growth-factor-receptor-positive-glioblastoma-using-lipid-encapsulated-targeted-superparamagnetic-iron-oxide-nanoparticles-in-vitro
#4
Huai-Lu Chen, Fei-Ting Hsu, Yu-Chieh Jill Kao, Hua-Shan Liu, Wan-Zhen Huang, Chia-Feng Lu, Ping-Huei Tsai, Ahmed Atef Ahmed Ali, Gilbert Aaron Lee, Ray-Jade Chen, Cheng-Yu Chen
BACKGROUND: Targeted superparamagnetic iron oxide (SPIO) nanoparticles have emerged as a promising biomarker detection tool for molecular magnetic resonance (MR) image diagnosis. To identify patients who could benefit from Epidermal growth factor receptor (EGFR)-targeted therapies, we introduce lipid-encapsulated SPIO nanoparticles and hypothesized that anti-EGFR antibody cetuximab conjugated of such nanoparticles can be used to identify EGFR-positive glioblastomas in non-invasive T2 MR image assays...
November 22, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29120646/critical-study-of-the-recognition-between-c-reactive-protein-and-surface-immobilized-phosphorylcholine-by-quartz-crystal-microbalance-with-dissipation
#5
Jhih-Guang Wu, Shu-Chen Wei, Yue Chen, Jie-Hao Chen, Shyh-Chyang Luo
C-reactive protein (CRP), a biomarker for cardiovascular disease, has been reported to have a strong affinity to zwitterionic phosphorylcholine (PC) groups in the presence of calcium ions. In addition, PC-immobilized surfaces have been used as a nonfouling coating to prevent nonspecific protein binding. By appropriately using the features of PC-immobilized surfaces, including specific recognition to CRP and nonfouling surface, it is reasonable to create an antibody-free biosensor for the specific capture of CRP...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28921971/paper-sensor-coated-with-a-poly-carboxybetaine-multiple-dopa-conjugate-via-dip-coating-for-biosensing-in-complex-media
#6
Fang Sun, Kan Wu, Hsiang-Chieh Hung, Peng Zhang, Xinran Che, Joshua Smith, Xiaojie Lin, Bowen Li, Priyesh Jain, Qiuming Yu, Shaoyi Jiang
Cellulose paper is an ideal diagnostic platform for low-cost, easily disposable and lightweight implementation, but requires surface modification to achieve detection with high sensitivity and specificity in complex media. In this work, a polymer-catechol conjugate containing a superhydrophilic nonfouling poly(carboxylbetaine) (pCB) and four surface-binding l-3,4-dihydroxyphenylalanine (DOPA) groups, pCB-(DOPA)4, were applied onto a paper-based sensor surface via a simple "graft-to" immersion process to render the surface with both nonfouling and protein functionalizable properties...
October 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28830143/epoxylated-zwitterionic-triblock-copolymers-grafted-onto-metallic-surfaces-for-general-biofouling-mitigation
#7
Ying-Nien Chou, Antoine Venault, Chia-Ho Cho, Mei-Chan Sin, Lu-Chen Yeh, Jheng-Fong Jhong, Arunachalam Chinnathambi, Yu Chang, Yung Chang
Titanium and stainless steel materials are widely used in numerous devices or in custom parts for their excellent mechanical properties. However, their lack of biocompatibility seriously limits their usage in the biomedical field. This study focuses on the grafting of triblock copolymers on titanium and stainless steel metal susbtrates for improving their general biofouling resistance. The series of copolymers that we designed is composed of two blocks of zwitterionic sulfobetaine (SBMA) monomers and one block of glycidyl methacrylate (GMA)...
September 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28648077/stable-and-functionalizable-quantum-dots-with-a-thin-zwitterionic-carboxybetaine-layer
#8
Wei Yang, Jean-Rene Ella-Menye, Tao Bai, Andrew Sinclair, Shaoyi Jiang
A new type of ligand chemistry, with a zwitterionic carboxybetaine headgroup and a bidentate thiol end group (CBSS), is introduced to promote the stability of quantum dots (QDs) with targeting capability. Results show that QDs are stable over a broad range of pH values after surface modification. Surface binding assays and cellular internalization studies show that QDs capped with CBSS exhibit low nonspecific adsorption. The CBSS ligand also allows the conjugation of highly specific targeting ligands while effectively maintaining the nonfouling background...
July 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28620970/a-coating-free-nonfouling-polymeric-elastomer
#9
Hsiang-Chieh Hung, Priyesh Jain, Peng Zhang, Fang Sun, Andrew Sinclair, Tao Bai, Bowen Li, Kan Wu, Caroline Tsao, Erik J Liu, Harihara S Sundaram, Xiaojie Lin, Payam Farahani, Timothy Fujihara, Shaoyi Jiang
Medical devices face nonspecific biofouling from proteins, cells, and microorganisms, which significantly contributes to complications and device failure. Imparting these devices with nonfouling capabilities remains a major challenge, particularly for those made from elastomeric polymers. Current strategies, including surface coating and copolymerization/physical blending, necessitate compromise among nonfouling properties, durability, and mechanical strength. Here, a new strategy is reported to achieve both high bulk mechanical strength and excellent surface nonfouling properties, which are typically contradictory, in one material...
June 16, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28616967/effects-of-functional-groups-of-materials-on-nonspecific-adhesion-and-chondrogenic-induction-of-mesenchymal-stem-cells-on-free-and-micropatterned-surfaces
#10
Bin Cao, Yuanmeng Peng, Xiangnan Liu, Jiandong Ding
Functional groups of materials are known to affect cell behaviors, yet the corresponding effect on stem cell differentiation is always coupled with that of cell spreading; it is thus unclear whether the chemical groups influence cell differentiation directly or via cell spreading indirectly. Herein we used a unique surface patterning technique to decouple the corresponding effects. Mesenchymal stem cells (MSCs) derived from bone marrow were seeded on surfaces coated with alkanethiols with one of four functional end groups (-CH3, -OH, -COOH, and -NH2) and underwent 9 days of chondrogenic induction...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28561563/reducing-friction-in-the-eye-a-comparative-study-of-lubrication-by-surface-anchored-synthetic-and-natural-ocular-mucin-analogues
#11
Olof Sterner, Chrysanthi Karageorgaki, Massimiliano Zürcher, Stefan Zürcher, Charles W Scales, Zohra Fadli, Nicholas D Spencer, Samuele G P Tosatti
Biomaterials used in the ocular environment should exhibit specific tribological behavior to avoid discomfort and stress-induced epithelial damage during blinking. In this study, two macromolecules that are commonly employed as ocular biomaterials, namely, poly(vinylpyrrolidone) (PVP) and hyaluronan (HA), are compared with two known model glycoproteins, namely bovine submaxillary mucin (BSM) and α1-acid glycoprotein (AGP), with regard to their nonfouling efficiency, wettability, and tribological properties when freely present in the lubricant, enabling spontaneous adsorption, and when chemisorbed under low contact pressures...
May 31, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28511543/sterilization-hydration-dehydration-and-tube-fabrication-of-zwitterionic-hydrogels
#12
Xia Han, Hsiang-Chieh Hung, Priyesh Jain, Fang Sun, Xuewei Xu, Wei Yang, Tao Bai, Shaoyi Jiang
Terminal sterilization of hydrogel-based biomaterials is crucial for their clinically relevant applications. The authors synthesized nonfouling zwitterionic hydrogels consisting of carboxybetaine (CB) acrylamide monomer and a carboxybetaine dimethacrylate crosslinker. The mechanical and biological stability of nonfouling hydrogels were investigated using three main terminal sterilization techniques, i.e., steam autoclave, ethylene oxide gas, and gamma irradiation. It was found that CB hydrogels are very stable at high temperature and pressure and in oxidative gas environments without changing their stress, modulus, and nonfouling properties...
May 16, 2017: Biointerphases
https://www.readbyqxmd.com/read/28403612/polymer-coated-ultrastable-and-biofunctionalizable-lanthanide-nanoparticles
#13
Yurong Que, Chun Feng, Guolin Lu, Xiaoyu Huang
Lanthanide-containing nanoparticles (LnNPs), for example, NaYF4, are considered to be one of the most promising platforms for biological and material applications due to their unique and unusual magnetic and upconversion fluorescent properties. However, limited water dispersity, low long-term colloidal stability, and difficulty in further functionalization greatly narrow the scope of their application in the real world. Herein, we report a facile strategy to counter the aforementioned barriers to the expanding use of LnNPs that involves surface-coating the LnNPs with poly(ethylene glycol)-b-poly(pentafluorophenyl methacrylate)/phosphonic acid and subsequently shell cross-linking with NH2-PEG-NH2...
April 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28380299/lipid-layers-on-nanoscale-surface-topography-stability-and-effect-on-protein-adsorption
#14
Irma Liascukiene, Karim El Kirat, Mathieu Beauvais, Svajus J Asadauskas, Jean-François Lambert, Jessem Landoulsi
Herein, we report the coating of a surface with a random nanoscale topography with a lipid film formed by an anchoring stearic acid (SA) monolayer and phospholipid (DPPC) layers. For this purpose, different procedures were used for phospholipid coating, including adsorption from solution, drop deposition, and spin-coating. Our results reveal that the morphology of the obtained lipid films is strongly influenced by the topography of the underlying substrate but also impacted by other factors, including the coating procedure and surface wettability (modulated by the presence of SA)...
May 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28252277/achieving-ultralow-fouling-under-ambient-conditions-via-surface-initiated-arget-atrp-of-carboxybetaine
#15
Daewha Hong, Hsiang-Chieh Hung, Kan Wu, Xiaojie Lin, Fang Sun, Peng Zhang, Sijun Liu, Keith E Cook, Shaoyi Jiang
We achieved ultralow fouling on target surfaces by controlled polymerization of carboxybetaine under ambient conditions. The polymerization process for grafting polymer films onto the surfaces was carried out in air and did not require any deoxygenation step or specialized equipment. This method allows one to conveniently introduce a nonfouling polymer network onto large substrates.
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28147481/a-zwitterionic-shielded-carrier-with-ph-modulated-reversible-self-assembly-for-gene-transfection
#16
Yuju Shih, Antoine Venault, Lemmuel L Tayo, Sheng-Han Chen, Akon Higuchi, Andre Deratani, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Damien Quemener, Yung Chang
Cationic vectors are ideal candidates for gene delivery thanks to their capability to carry large gene inserts and their scalable production. However, their cationic density gives rise to high cytotoxicity. We present the proper designed core-shell polyplexes made of either poly(ethylene imine) (PEI) or poly(2-dimethylamino ethyl methacrylate) (PDMAEMA) as the core and zwitterionic poly(acrylic acid)-block-poly(sulfobetaine methacrylate) (PAA-b-PSBMA) diblock copolymer as the shell. Gel retardation and ethidium bromide displacement assays were used to determine the PEI/DNA or PDMAEMA/DNA complexation...
February 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28053527/fabrication-of-nonfouling-bactericidal-and-bacteria-corpse-release-multifunctional-surface-through-surface-initiated-raft-polymerization
#17
Bailiang Wang, Zi Ye, Yihong Tang, Yuemei Han, Quankui Lin, Huihua Liu, Hao Chen, Kaihui Nan
Infections after surgery or endophthalmitis are potentially blinding complications caused by bacterial adhesion and subsequent biofilm formation on the intraocular lens. Neither single-function anti-adhesion surface nor contacting killing surface can exhibit ideal antibacterial function. In this work, a novel (2-(dimethylamino)-ethyl methacrylate-co-2-methacryloyloxyethyl phosphorylcholine) (p (DMAEMA-co-MPC)) brush was synthesized by "grafting from" method through reversible-addition fragmentation chain transfer polymerization...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28009508/synthesis-and-antibacterial-study-of-sulfobetaine-quaternary-ammonium-modified-star-shaped-poly-2-dimethylamino-ethyl-methacrylate-based-copolymers-with-an-inorganic-core
#18
Yuji Pu, Zheng Hou, Mya Mya Khin, Rubi Zamudio-Vázquez, Kar Lai Poon, Hongwei Duan, Mary B Chan-Park
Cationic polymethacrylates are interesting candidates for bacterial disinfectants since they can be made in large-scale by various well-established polymerization techniques such as atom transfer radical polymerization (ATRP). However, they are usually toxic or ineffective in serum and various strategies to improve their biocompatibility or nonfouling property have often resulted in compromised bactericidal activity. Also, star-shaped polymers are less explored than linear polymers for application as antibacterial compounds...
January 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/27692715/evaluation-of-modified-stainless-steel-surfaces-targeted-to-reduce-biofilm-formation-by-common-milk-sporeformers
#19
Shivali Jindal, Sanjeev Anand, Kang Huang, Julie Goddard, Lloyd Metzger, Jayendra Amamcharla
The development of bacterial biofilms on stainless steel (SS) surfaces poses a great threat to the quality of milk and other dairy products as the biofilm-embedded bacteria can survive thermal processing. Established biofilms offer cleaning challenges because they are resistant to most of the regular cleaning protocols. Sporeforming thermoduric organisms entrapped within biofilm matrix can also form heat-resistant spores, and may result in a long-term persistent contamination. The main objective of this study was to evaluate the efficacy of different nonfouling coatings [AMC 18 (Advanced Materials Components Express, Lemont, PA), Dursan (SilcoTek Corporation, Bellefonte, PA), Ni-P-polytetrafluoroethylene (PTFE, Avtec Finishing Systems, New Hope, MN), and Lectrofluor 641 (General Magnaplate Corporation, Linden, NJ)] on SS plate heat exchanger surfaces, to resist the formation of bacterial biofilms...
December 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27460261/candle-soot-based-super-amphiphobic-coatings-resist-protein-adsorption
#20
Lars Schmüser, Noemi Encinas, Maxime Paven, Daniel J Graham, David G Castner, Doris Vollmer, Hans Jürgen Butt, Tobias Weidner
Super nonfouling surfaces resist protein adhesion and have a broad field of possible applications in implant technology, drug delivery, blood compatible materials, biosensors, and marine coatings. A promising route toward nonfouling surfaces involves liquid repelling architectures. The authors here show that soot-templated super-amphiphobic (SAP) surfaces prepared from fluorinated candle soot structures are super nonfouling. When exposed to bovine serum albumin or blood serum, x-ray photoelectron spectroscopy and time of flight secondary ion mass spectrometry analysis showed that less than 2 ng/cm(2) of protein was adsorbed onto the SAP surfaces...
September 26, 2016: Biointerphases
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