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https://www.readbyqxmd.com/read/27692715/evaluation-of-modified-stainless-steel-surfaces-targeted-to-reduce-biofilm-formation-by-common-milk-sporeformers
#1
Shivali Jindal, Sanjeev Anand, Kang Huang, Julie Goddard, Lloyd Metzger, Jayendra Amamcharla
The development of bacterial biofilms on stainless steel (SS) surfaces poses a great threat to the quality of milk and other dairy products as the biofilm-embedded bacteria can survive thermal processing. Established biofilms offer cleaning challenges because they are resistant to most of the regular cleaning protocols. Sporeforming thermoduric organisms entrapped within biofilm matrix can also form heat-resistant spores, and may result in a long-term persistent contamination. The main objective of this study was to evaluate the efficacy of different nonfouling coatings [AMC 18 (Advanced Materials Components Express, Lemont, PA), Dursan (SilcoTek Corporation, Bellefonte, PA), Ni-P-polytetrafluoroethylene (PTFE, Avtec Finishing Systems, New Hope, MN), and Lectrofluor 641 (General Magnaplate Corporation, Linden, NJ)] on SS plate heat exchanger surfaces, to resist the formation of bacterial biofilms...
September 28, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27460261/candle-soot-based-super-amphiphobic-coatings-resist-protein-adsorption
#2
Lars Schmüser, Noemi Encinas, Maxime Paven, Daniel J Graham, David G Castner, Doris Vollmer, Hans Jürgen Butt, Tobias Weidner
Super nonfouling surfaces resist protein adhesion and have a broad field of possible applications in implant technology, drug delivery, blood compatible materials, biosensors, and marine coatings. A promising route toward nonfouling surfaces involves liquid repelling architectures. The authors here show that soot-templated super-amphiphobic (SAP) surfaces prepared from fluorinated candle soot structures are super nonfouling. When exposed to bovine serum albumin or blood serum, x-ray photoelectron spectroscopy and time of flight secondary ion mass spectrometry analysis showed that less than 2 ng/cm(2) of protein was adsorbed onto the SAP surfaces...
2016: Biointerphases
https://www.readbyqxmd.com/read/27363527/hierarchical-polymer-coating-for-optimizing-the-antifouling-and-bactericidal-efficacies
#3
Shunjie Yan, Lingjie Song, Zhihong Li, Shifang Luan, Hengchong Shi, Zhirong Xin, Shenghai Li, Yuming Yang, Jinghua Yin
The bacteria-repellent and bactericidal functionalities in a single system are generally need to be carefully optimized in order to obtain the highest antibacterial performance. In this study, the controlled SI-PIMP strategy was developed for creating hierarchical polymer brushes possessing the bacteria-repellent and bactericidal functionalities. To obtain a bactericidal surface with minimal interference to its nonfouling property, optimization studies were conducted by facilely tailoring the surface density of the quaternary ammonium compound moieties through control over the monomer concentration...
October 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27351270/porosity-tuned-chitosan-polyacrylamide-hydrogel-microspheres-for-improved-protein-conjugation
#4
Sukwon Jung, John H Abel, Jesse L Starger, Hyunmin Yi
We report a robust method to manufacture polyacrylamide-based functional hydrogel microspheres with readily tunable macroporous structures by utilizing a simple micromolding-based technique. Specifically, surface tension-induced droplet formation of aqueous solutions of chitosan and acrylamide in 2D-shaped micromolds followed by photoinduced polymerization leads to monodisperse microspheres. Pore sizes of the microspheres can be readily tuned by simple addition of inert long-chain poly(ethylene glycol) porogen at low content in the prepolymer solution...
July 11, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27265149/low-fouling-electrospun-plla-films-modified-with-zwitterionic-poly-sulfobetaine-methacrylate-catechol-conjugates
#5
Wenjing Yang, Harihara S Sundaram, Jean-Rene Ella, Nongyue He, Shaoyi Jiang
UNLABELLED: In this work, we modified a hydrophobic electrospun poly (l-lactic) acid (PLLA) film with poly (sulfobetaine methacrylate) (pSBMA)-catechol conjugates of different molecular weights to improve the biocompatibility of the film. These conjugates were synthesized via atom transfer radical polymerization. They consist of an ultra-low fouling pSBMA zwitterionic polymer with a surface-adhesive catechol moiety. X-ray photoelectron spectroscopy, contact angle and scanning electron microscopy experiments were performed to characterize films before and after modification with pSBMA-catechol conjugates...
August 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27213986/durable-antibacterial-and-nonfouling-cotton-textiles-with-enhanced-comfort-via-zwitterionic-sulfopropylbetaine-coating
#6
Shiguo Chen, Lingjun Yuan, Qingqing Li, Jianna Li, Xingli Zhu, Yongguang Jiang, Ou Sha, Xinhui Yang, John H Xin, Jiangxin Wang, Florian J Stadler, Peng Huang
A rapid, environment-friendly, and cost-effective finishing method has been developed for cotton textiles by using zwitterionic NCO-sulfopropylbetaine as the antibacterial finishing agent through covalent bond. The sulfopropylbetaine-finished cotton textile exhibits durable broad-spectrum antibacterial and nonfouling activity, improved mechanical properties, and enhanced comfort.
July 2016: Small
https://www.readbyqxmd.com/read/27142255/protein-diffusion-characteristics-in-the-hydrogels-of-poly-ethylene-glycol-and-zwitterionic-poly-sulfobetaine-methacrylate-psbma
#7
Jiang Wu, Zecong Xiao, Chaochao He, Jingjing Zhu, Guanglong Ma, Guangzhi Wang, Hongyu Zhang, Jian Xiao, Shengfu Chen
UNLABELLED: Nonfouling materials such as neutral poly(ethylene glycol) (PEG) and zwitterionic poly(sulfobetaine methacrylate) (pSBMA) are ideal biocompatible materials for drug, especially protein drug delivery. The interaction behavior of protein between the nonfouling materials could cause great impact on their future applications, such as controlled release drug delivery systems. In this work, we investigated the diffusion behavior of the fluorescence-labeled model proteins (bovine serum albumin (BSA) and lysozyme (LYZ)) in nonfouling PEG, pSBMA and mixed PEG-SBMA hydrogels (SBMA:PEG 4:1, SBMA:PEG 1:4)...
August 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27090589/ultra-low-fouling-and-high-antibody-loading-zwitterionic-hydrogel-coatings-for-sensing-and-detection-in-complex-media
#8
Ying-Nien Chou, Fang Sun, Hsiang-Chieh Hung, Priyesh Jain, Andrew Sinclair, Peng Zhang, Tao Bai, Yung Chang, Ten-Chin Wen, Qiuming Yu, Shaoyi Jiang
UNLABELLED: For surface-based diagnostic devices to achieve reliable biomarker detection in complex media such as blood, preventing nonspecific protein adsorption and incorporating high loading of biorecognition elements are paramount. In this work, a novel method to produce nonfouling zwitterionic hydrogel coatings was developed to achieve these goals. Poly(carboxybetaine acrylamide) (pCBAA) hydrogel thin films (CBHTFs) prepared with a carboxybetaine diacrylamide crosslinker (CBAAX) were coated on gold and silicon dioxide surfaces via a simple spin coating process...
August 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27063489/achieving-low-fouling-surfaces-with-oppositely-charged-polysaccharides-via-lbl-assembly
#9
Yuping Wei, Hsiang-Chieh Hung, Fang Sun, Tao Bai, Peng Zhang, Ann Kate Nowinski, Shaoyi Jiang
UNLABELLED: The aim of this work is to understand and achieve low fouling surfaces by mixing two oppositely charged polysaccharides through layer-by-layer (LBL) assembly. Diethylaminoethyl-dextran hydrochloride and alginate were employed as a model system to build LBL films. A surface plasmon resonance (SPR) biosensor was used to measure quantitatively the adsorption behavior of charged macromolecules during LBL buildup and the protein adsorption behavior of each deposited bilayer in situ in real time accordingly...
August 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27057004/increased-survival-and-function-of-mesenchymal-stem-cell-spheroids-entrapped-in-instructive-alginate-hydrogels
#10
Steve S Ho, Kaitlin C Murphy, Bernard Y K Binder, Caroline B Vissers, J Kent Leach
UNLABELLED: Mesenchymal stem cell (MSC)-based therapies are under broad investigation for applications in tissue repair but suffer from poor cell persistence and engraftment upon transplantation. MSC spheroids exhibit improved survival, anti-inflammatory, and angiogenic potential in vitro, while also promoting vascularization when implanted in vivo. However, these benefits are lost once cells engage the tissue extracellular matrix and migrate from the aggregate. The efficacy of cell therapy is consistently improved when using engineered materials, motivating the need to investigate the role of biomaterials to instruct spheroid function...
June 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/26992370/photo-assisted-generation-of-phospholipid-polymer-substrates-for-regiospecific-protein-conjugation-and-control-of-cell-adhesion
#11
Masako Tanaka, Yasuhiko Iwasaki
UNLABELLED: Novel photo-reactive phospholipid polymers were synthesized for use in the preparation of nonfouling surfaces with protein conjugation capacity. Poly[2-methacryloyloxyethyl phosphorylcholine (MPC)-ran-N-methacryloyl-(l)-tyrosinemethylester (MAT)] (P(MPC/MAT)) was synthesized by conventional radical polymerization, with the MAT units capable of being oxidized by 254nm UV irradiation. Because of this photo-oxidation, active species such as catechol and quinone were alternately generated in the copolymer...
August 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/26953817/microphase-separated-pe-peo-thin-films-prepared-by-plasma-assisted-vapor-phase-deposition
#12
Andrei Choukourov, Ivan Gordeev, Jessica Ponti, Chiara Uboldi, Iurii Melnichuk, Mykhailo Vaidulych, Jaroslav Kousal, Daniil Nikitin, Lenka Hanyková, Ivan Krakovský, Danka Slavínská, Hynek Biederman
Immiscible polymer blends tend to undergo phase separation with the formation of nanoscale architecture which can be used in a variety of applications. Different wet-chemistry techniques already exist to fix the resultant polymeric structure in predictable manner. In this work, an all-dry and plasma-based strategy is proposed to fabricate thin films of microphase-separated polyolefin/polyether blends. This is achieved by directing (-CH2-)100 and (-CH2-CH2-O-)25 oligomer fluxes produced by vacuum thermal decomposition of poly(ethylene) and poly(ethylene oxide) onto silicon substrates through the zone of the glow discharge...
March 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26863201/encoded-hydrogel-microparticles-for-sensitive-and-multiplex-microrna-detection-directly-from-raw-cell-lysates
#13
Hyewon Lee, Sarah J Shapiro, Stephen C Chapin, Patrick S Doyle
In recent years, microRNAs (miRNAs) have emerged as promising diagnostic markers because of their unique dysregulation patterns under various disease conditions and high stability in biological fluids. However, current methods of analyzing miRNA levels typically require RNA isolation, which is cumbersome and time-consuming. To achieve high-throughput and accurate miRNA profiling, this study eliminates the need for purification steps by detecting miRNA directly from raw cellular lysate using nonfouling polyethylene glycol microparticles...
March 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/26858017/imparting-nonfouling-properties-to-chemically-distinct-surfaces-with-a-single-adsorbing-polymer-a-multimodal-binding-approach
#14
Ângela Serrano, Stefan Zürcher, Samuele Tosatti, Nicholas D Spencer
Surface-active polymers that display nonfouling properties and carry binding groups that can adsorb onto different substrates are highly desirable. We present a postmodification protocol of an active-ester-containing polymer that allows the creation of such a versatile platform. Poly(pentafluorophenyl acrylate) has been postmodified with a fixed grafting ratio of a nonfouling function (mPEG) and various combinations of functional groups, such as amine, silane and catechol, which can provide strong affinity to two model substrates: SiO2 and TiO2 ...
April 2016: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/26726866/nonfouling-nta-peg-based-tem-grid-coatings-for-selective-capture-of-histidine-tagged-protein-targets-from-cell-lysates
#15
Christopher J Benjamin, Kyle J Wright, Seok-Hee Hyun, Kyle Krynski, Guimei Yu, Ruchika Bajaj, Fei Guo, Cynthia V Stauffacher, Wen Jiang, David H Thompson
We report the preparation and performance of TEM grids bearing stabilized nonfouling lipid monolayer coatings. These films contain NTA capture ligands of controllable areal density at the distal end of a flexible poly(ethylene glycol) 2000 (PEG2000) spacer to avoid preferred orientation of surface-bound histidine-tagged (His-tag) protein targets. Langmuir-Schaefer deposition at 30 mN/m of mixed monolayers containing two novel synthetic lipids-1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[(5-amido-1-carboxypentyl)iminodiacetic acid]polyethylene glycolamide 2000) (NTA-PEG2000-DSPE) and 1,2-(tricosa-10',12'-diynoyl)-sn-glycero-3-phosphoethanolamine-N-(methoxypolyethylene glycolamide 350) (mPEG350-DTPE)-in 1:99 and 5:95 molar ratios prior to treatment with a 5 min, 254 nm light exposure was used for grid fabrication...
January 19, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/26671880/mussel-inspired-polymer-carpets-direct-photografting-of-polymer-brushes-on-polydopamine-nanosheets-for-controlled-cell-adhesion
#16
Daniel Hafner, Lisa Ziegler, Muhammad Ichwan, Tao Zhang, Maximilian Schneider, Michael Schiffmann, Claudia Thomas, Karsten Hinrichs, Rainer Jordan, Ihsan Amin
2D mussel-inspired polydopamine (PDA) nanosheets are prepared and exploited as a functional surface for grafting various polymer brushes. The PDA nanosheet and its polymer-brush derivatives show lateral integrity and are robust; therefore, they can be detached from their substrates. Cell-adhesion tests show that the PDA nanosheet promotes cell growth and attachment, while a PDA-based poly(3-sulfopropyl methacrylate) carpet exhibits nonfouling behavior.
February 17, 2016: Advanced Materials
https://www.readbyqxmd.com/read/26618931/surface-charge-convertible-and-biodegradable-synthetic-zwitterionic-nanoparticles-for-enhancing-cellular-drug-uptake
#17
Luyan Wu, Caihua Ni, Liping Zhang, Gang Shi, Xue Bai, Yamin Zhou, Fei He
To enhance drug cellular uptake, a biodegradable terpolymer is synthesized using taurine, N,N-Bis (acryloyl) cystamine, and dodecylamine as raw materials by Michael addition terpolymerization. The terpolymer is transformed to zwitterionic nanoparticles (NPs) through self-assembly. The surface charge of the NPs is convertible from negative at pH 7.4 to positive at pH 6.5, which endows the NPs' excellent nonfouling feature in bloodstream and effective uptake in tumor cells. The NPs display varied morphologies from solid micelles to polymersomes and nanorods depending on molar ratios of the structural units involved...
March 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/26606238/characterizing-drug-release-from-nonfouling-polyampholyte-hydrogels
#18
Marcos N Barcellona, Nicholas Johnson, Matthew T Bernards
Controlled delivery of bioactive signaling molecules and drugs is essential for the development of the next generation of tissue regeneration scaffolds. However, these molecules must be delivered from a nonfouling platform, so that the therapeutic role is not masked by the naturally occurring foreign body response. Therefore, the purpose of this study is to characterize the release profiles of three pseudodrug molecules from a nonfouling polyampholyte hydrogel to gain insight into the potential for this platform to serve as a tissue regeneration scaffold...
December 15, 2015: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/26600563/interplay-of-matrix-stiffness-and-cell-cell-contact-in-regulating-differentiation-of-stem-cells
#19
Kai Ye, Luping Cao, Shiyu Li, Lin Yu, Jiandong Ding
Stem cells are capable of sensing and responding to the mechanical properties of extracellular matrixes (ECMs). It is well-known that, while osteogenesis is promoted on the stiff matrixes, adipogenesis is enhanced on the soft ones. Herein, we report an "abnormal" tendency of matrix-stiffness-directed stem cell differentiation. Well-defined nanoarrays of cell-adhesive arginine-glycine-aspartate (RGD) peptides were modified onto the surfaces of persistently nonfouling poly(ethylene glycol) (PEG) hydrogels to achieve controlled specific cell adhesion and simultaneously eliminate nonspecific protein adsorption...
August 31, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26588215/stably-doped-conducting-polymer-nanoshells-by-surface-initiated-polymerization
#20
Junwei Li, Soon Joon Yoon, Bao-Yu Hsieh, Wanyi Tai, Matthew O'Donnell, Xiaohu Gao
Despite broad applications ranging from electronics to biomedical sensing and imaging, a long-standing problem of conducting polymers is the poor resistance to dedoping, which directly affects their signature electrical and optical properties. This problem is particularly significant for biomedical uses because of fast leaching of dopant ions in physiological environments. Here, we describe a new approach to engineer multimodal core-shell nanoparticles with a stably doped conductive polymer shell in biological environments...
December 9, 2015: Nano Letters
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