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Thomas A Horbett
Fibrinogen (Fg) adsorption is an important mechanism underlying cell adhesion to biomaterials and was the major focus of the author's research career. This article summarizes our work on Fg adsorption, with citations of related work as appropriate. The molecular properties of Fg that promote adsorption and cell adhesion will be described. In addition, the adsorption behavior of Fg from buffer, binary solutions with other proteins, and blood plasma will be discussed, including the Vroman effect. Studies of platelet adhesion to surfaces preadsorbed with blood plasmas selectively deficient in Fg, vitronectin (Vn), fibronectin (Fn), or von Willebrand's factor (vWf) will be reviewed...
June 12, 2018: Journal of Biomedical Materials Research. Part A
Gujie Mi, Di Shi, Mian Wang, Thomas J Webster
With the rapid spreading of resistance among common bacterial pathogens, bacterial infections, especially antibiotic-resistant bacterial infections, have drawn much attention worldwide. In light of this, nanoparticles, including metal and metal oxide nanoparticles, liposomes, polymersomes, and solid lipid nanoparticles, have been increasingly exploited as both efficient antimicrobials themselves or as delivery platforms to enhance the effectiveness of existing antibiotics. In addition to the emergence of widespread antibiotic resistance, of equal concern are implantable device-associated infections, which result from bacterial adhesion and subsequent biofilm formation at the site of implantation...
May 22, 2018: Advanced Healthcare Materials
Chong Zhang, Jianhua Lu, Yingqin Hou, Wei Xiong, Kai Sheng, Hua Lu
Zwitterionic polymers are outstanding nonfouling materials widely used for surface modification. However, works that systematically evaluate the structure-activity relationship of the side chain linker effect with related antifouling abilities are sparse. Here, we generate a series of well-defined zwitterionic polypeptides bearing oligoethylene glycol (EG) linkers in the side chain (P(CB-EGx Glu), x = 1-3) and anchor them on gold surfaces via the grafting-to approach to compare their antifouling performances...
May 8, 2018: ACS Applied Materials & Interfaces
Yuanmeng Peng, Qiong-Jie Liu, Tianlei He, Kai Ye, Xiang Yao, Jiandong Ding
While various static cues such as matrix stiffness have been known to regulate stem cell differentiation, it is unclear whether or not dynamic cues such as degradation rate along with the change of material chemistry can influence cell behaviors beyond simple integration of static cues such as decreased matrix stiffness. The present research is aimed at examining effects of degradation rates on adhesion and differentiation of mesenchymal stem cells (MSCs) in vitro on well-defined synthetic hydrogel surfaces...
April 12, 2018: Biomaterials
Chang-Lin Wu, Jian-An He, Da-Yong Gu, Chao-Peng Shao, Yi Zhu, Xin-Tang Dang
BACKGROUND: This study was aimed to establish a novel strategy based on the surface plasmon resonance (SPR) technology for platelet compatibility testing. METHODS: A novel surface matrix was prepared based on poly (OEGMA-co-HEMA) via surface-initiated polymerization as a biosensor surface platform. Type O universal platelets and donor platelets were immobilized on these novel matrices via amine-coupling reaction and worked as a capturing ligand for binding the platelet antibody...
January 1, 2018: Clinical Laboratory
Chong Zhang, Jingsong Yuan, Jianhua Lu, Yingqin Hou, Wei Xiong, Hua Lu
The development of high-performance nonfouling polymer surfaces for implantable medical devices and therapeutic nanomaterials is of great importance. Elaborating the relationship of polymer structural characteristics and the resulted surface properties can offer useful guidance toward ideal biointerfaces. In this work, we investigate the effects of the helical conformation and anchoring orientation of poly(α-amino acid)s (PαAAs) to produce advanced nonfouling surfaces. By using the neutral poly(γ-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)esteryl glutamates) (P(EG3 Glu)s) as a model system, the adsorption kinetics are monitored by ex-situ variable angle spectroscopic ellipsometry and in-situ quartz crystal microbalance with dissipation...
February 3, 2018: Biomaterials
Inseong Choi, Jinhwan Lee, Wontae Kim, Hyunook Kang, Se Won Bae, Rakwoo Chang, Sunghyun Kim, Woon-Seok Yeo
This paper reports unprecedented dynamic surfaces based on zwitterionic low-density self-assembled monolayers (LDSAMs) of alkanethiolates on gold, which integrate three interconvertible states-bacteria-adherable, bactericidal, and nonfouling states-through electrical modulations. The conformations of alkanethiolates were electrically modulated to generate zwitterionic, anionic, and cationic surfaces, which responded differently to bacteria and determined the fate of bacteria. Furthermore, the reversible switching of multifunctions of the surface was realized for killing bacteria and subsequently releasing dead bacteria from the surface...
January 31, 2018: ACS Applied Materials & Interfaces
Thomas J Plegue, Kyle M Kovach, Alex J Thompson, Joseph A Potkay
Blood-material interactions are crucial to the lifetime, safety, and overall success of blood contacting devices. Hydrophilic polymer coatings have been employed to improve device lifetime by shielding blood contacting materials from the natural foreign body response, primarily the intrinsic pathway of the coagulation cascade. These coatings have the ability to repel proteins, cells, bacteria, and other micro-organisms. Coatings are desired to have long-term stability, so that the nonthrombogenic and nonfouling effects gained are long lasting...
January 9, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Huai-Lu Chen, Fei-Ting Hsu, Yu-Chieh Jill Kao, Hua-Shan Liu, Wan-Zhen Huang, Chia-Feng Lu, Ping-Huei Tsai, Ahmed Atef Ahmed Ali, Gilbert Aaron Lee, Ray-Jade Chen, Cheng-Yu Chen
BACKGROUND: Targeted superparamagnetic iron oxide (SPIO) nanoparticles have emerged as a promising biomarker detection tool for molecular magnetic resonance (MR) image diagnosis. To identify patients who could benefit from Epidermal growth factor receptor (EGFR)-targeted therapies, we introduce lipid-encapsulated SPIO nanoparticles and hypothesized that anti-EGFR antibody cetuximab conjugated of such nanoparticles can be used to identify EGFR-positive glioblastomas in non-invasive T2 MR image assays...
November 22, 2017: Journal of Nanobiotechnology
Jhih-Guang Wu, Shu-Chen Wei, Yue Chen, Jie-Hao Chen, Shyh-Chyang Luo
C-reactive protein (CRP), a biomarker for cardiovascular disease, has been reported to have a strong affinity to zwitterionic phosphorylcholine (PC) groups in the presence of calcium ions. In addition, PC-immobilized surfaces have been used as a nonfouling coating to prevent nonspecific protein binding. By appropriately using the features of PC-immobilized surfaces, including specific recognition to CRP and nonfouling surface, it is reasonable to create an antibody-free biosensor for the specific capture of CRP...
January 23, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Fang Sun, Kan Wu, Hsiang-Chieh Hung, Peng Zhang, Xinran Che, Joshua Smith, Xiaojie Lin, Bowen Li, Priyesh Jain, Qiuming Yu, Shaoyi Jiang
Cellulose paper is an ideal diagnostic platform for low-cost, easily disposable and lightweight implementation, but requires surface modification to achieve detection with high sensitivity and specificity in complex media. In this work, a polymer-catechol conjugate containing a superhydrophilic nonfouling poly(carboxylbetaine) (pCB) and four surface-binding l-3,4-dihydroxyphenylalanine (DOPA) groups, pCB-(DOPA)4, were applied onto a paper-based sensor surface via a simple "graft-to" immersion process to render the surface with both nonfouling and protein functionalizable properties...
October 17, 2017: Analytical Chemistry
Ying-Nien Chou, Antoine Venault, Chia-Ho Cho, Mei-Chan Sin, Lu-Chen Yeh, Jheng-Fong Jhong, Arunachalam Chinnathambi, Yu Chang, Yung Chang
Titanium and stainless steel materials are widely used in numerous devices or in custom parts for their excellent mechanical properties. However, their lack of biocompatibility seriously limits their usage in the biomedical field. This study focuses on the grafting of triblock copolymers on titanium and stainless steel metal susbtrates for improving their general biofouling resistance. The series of copolymers that we designed is composed of two blocks of zwitterionic sulfobetaine (SBMA) monomers and one block of glycidyl methacrylate (GMA)...
September 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Wei Yang, Jean-Rene Ella-Menye, Tao Bai, Andrew Sinclair, Shaoyi Jiang
A new type of ligand chemistry, with a zwitterionic carboxybetaine headgroup and a bidentate thiol end group (CBSS), is introduced to promote the stability of quantum dots (QDs) with targeting capability. Results show that QDs are stable over a broad range of pH values after surface modification. Surface binding assays and cellular internalization studies show that QDs capped with CBSS exhibit low nonspecific adsorption. The CBSS ligand also allows the conjugation of highly specific targeting ligands while effectively maintaining the nonfouling background...
July 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Hsiang-Chieh Hung, Priyesh Jain, Peng Zhang, Fang Sun, Andrew Sinclair, Tao Bai, Bowen Li, Kan Wu, Caroline Tsao, Erik J Liu, Harihara S Sundaram, Xiaojie Lin, Payam Farahani, Timothy Fujihara, Shaoyi Jiang
Medical devices face nonspecific biofouling from proteins, cells, and microorganisms, which significantly contributes to complications and device failure. Imparting these devices with nonfouling capabilities remains a major challenge, particularly for those made from elastomeric polymers. Current strategies, including surface coating and copolymerization/physical blending, necessitate compromise among nonfouling properties, durability, and mechanical strength. Here, a new strategy is reported to achieve both high bulk mechanical strength and excellent surface nonfouling properties, which are typically contradictory, in one material...
June 16, 2017: Advanced Materials
Bin Cao, Yuanmeng Peng, Xiangnan Liu, Jiandong Ding
Functional groups of materials are known to affect cell behaviors, yet the corresponding effect on stem cell differentiation is always coupled with that of cell spreading; it is thus unclear whether the chemical groups influence cell differentiation directly or via cell spreading indirectly. Herein we used a unique surface patterning technique to decouple the corresponding effects. Mesenchymal stem cells (MSCs) derived from bone marrow were seeded on surfaces coated with alkanethiols with one of four functional end groups (-CH3, -OH, -COOH, and -NH2) and underwent 9 days of chondrogenic induction...
July 19, 2017: ACS Applied Materials & Interfaces
Olof Sterner, Chrysanthi Karageorgaki, Massimiliano Zürcher, Stefan Zürcher, Charles W Scales, Zohra Fadli, Nicholas D Spencer, Samuele G P Tosatti
Biomaterials used in the ocular environment should exhibit specific tribological behavior to avoid discomfort and stress-induced epithelial damage during blinking. In this study, two macromolecules that are commonly employed as ocular biomaterials, namely, poly(vinylpyrrolidone) (PVP) and hyaluronan (HA), are compared with two known model glycoproteins, namely bovine submaxillary mucin (BSM) and α1-acid glycoprotein (AGP), with regard to their nonfouling efficiency, wettability, and tribological properties when freely present in the lubricant, enabling spontaneous adsorption, and when chemisorbed under low contact pressures...
May 31, 2017: ACS Applied Materials & Interfaces
Xia Han, Hsiang-Chieh Hung, Priyesh Jain, Fang Sun, Xuewei Xu, Wei Yang, Tao Bai, Shaoyi Jiang
Terminal sterilization of hydrogel-based biomaterials is crucial for their clinically relevant applications. The authors synthesized nonfouling zwitterionic hydrogels consisting of carboxybetaine (CB) acrylamide monomer and a carboxybetaine dimethacrylate crosslinker. The mechanical and biological stability of nonfouling hydrogels were investigated using three main terminal sterilization techniques, i.e., steam autoclave, ethylene oxide gas, and gamma irradiation. It was found that CB hydrogels are very stable at high temperature and pressure and in oxidative gas environments without changing their stress, modulus, and nonfouling properties...
May 16, 2017: Biointerphases
Yurong Que, Chun Feng, Guolin Lu, Xiaoyu Huang
Lanthanide-containing nanoparticles (LnNPs), for example, NaYF4, are considered to be one of the most promising platforms for biological and material applications due to their unique and unusual magnetic and upconversion fluorescent properties. However, limited water dispersity, low long-term colloidal stability, and difficulty in further functionalization greatly narrow the scope of their application in the real world. Herein, we report a facile strategy to counter the aforementioned barriers to the expanding use of LnNPs that involves surface-coating the LnNPs with poly(ethylene glycol)-b-poly(pentafluorophenyl methacrylate)/phosphonic acid and subsequently shell cross-linking with NH2-PEG-NH2...
April 21, 2017: ACS Applied Materials & Interfaces
Irma Liascukiene, Karim El Kirat, Mathieu Beauvais, Svajus J Asadauskas, Jean-François Lambert, Jessem Landoulsi
Herein, we report the coating of a surface with a random nanoscale topography with a lipid film formed by an anchoring stearic acid (SA) monolayer and phospholipid (DPPC) layers. For this purpose, different procedures were used for phospholipid coating, including adsorption from solution, drop deposition, and spin-coating. Our results reveal that the morphology of the obtained lipid films is strongly influenced by the topography of the underlying substrate but also impacted by other factors, including the coating procedure and surface wettability (modulated by the presence of SA)...
May 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Daewha Hong, Hsiang-Chieh Hung, Kan Wu, Xiaojie Lin, Fang Sun, Peng Zhang, Sijun Liu, Keith E Cook, Shaoyi Jiang
We achieved ultralow fouling on target surfaces by controlled polymerization of carboxybetaine under ambient conditions. The polymerization process for grafting polymer films onto the surfaces was carried out in air and did not require any deoxygenation step or specialized equipment. This method allows one to conveniently introduce a nonfouling polymer network onto large substrates.
March 22, 2017: ACS Applied Materials & Interfaces
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