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https://www.readbyqxmd.com/read/28648077/stable-and-functionalizable-quantum-dots-with-a-thin-zwitterionic-carboxybetaine-layer
#1
Wei Yang, Jean-Rene Ella-Menye, Tao Bai, Andrew Sinclair, Shaoyi Jiang
A new type of ligand chemistry, with a zwitterionic carboxybetaine headgroup and a bidentate thiol end group (CBSS), is introduced to promote the stability of quantum dots (QDs) with targeting capability. Results show that QDs are stable over a broad range of pH values after surface modification. Surface binding assays and cellular internalization studies show that QDs capped with CBSS exhibit low nonspecific adsorption. The CBSS ligand also allows the conjugation of highly specific targeting ligands while effectively maintaining the nonfouling background...
July 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28620970/a-coating-free-nonfouling-polymeric-elastomer
#2
Hsiang-Chieh Hung, Priyesh Jain, Peng Zhang, Fang Sun, Andrew Sinclair, Tao Bai, Bowen Li, Kan Wu, Caroline Tsao, Erik J Liu, Harihara S Sundaram, Xiaojie Lin, Payam Farahani, Timothy Fujihara, Shaoyi Jiang
Medical devices face nonspecific biofouling from proteins, cells, and microorganisms, which significantly contributes to complications and device failure. Imparting these devices with nonfouling capabilities remains a major challenge, particularly for those made from elastomeric polymers. Current strategies, including surface coating and copolymerization/physical blending, necessitate compromise among nonfouling properties, durability, and mechanical strength. Here, a new strategy is reported to achieve both high bulk mechanical strength and excellent surface nonfouling properties, which are typically contradictory, in one material...
June 16, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28616967/effects-of-functional-groups-of-materials-on-nonspecific-adhesion-and-chondrogenic-induction-of-mesenchymal-stem-cells-on-free-and-micropatterned-surfaces
#3
Bin Cao, Yuanmeng Peng, Xiangnan Liu, Jiandong Ding
Functional groups of materials are known to affect cell behaviors, yet the corresponding effect on stem cell differentiation is always coupled with that of cell spreading; it is thus unclear whether the chemical groups influence cell differentiation directly or via cell spreading indirectly. Herein we used a unique surface patterning technique to decouple the corresponding effects. Mesenchymal stem cells (MSCs) derived from bone marrow were seeded on surfaces coated with alkanethiols with one of four functional end groups (-CH3, -OH, -COOH, and -NH2) and underwent 9 days of chondrogenic induction...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28561563/reducing-friction-in-the-eye-a-comparative-study-of-lubrication-by-surface-anchored-synthetic-and-natural-ocular-mucin-analogues
#4
Olof Sterner, Chrysanthi Karageorgaki, Massimiliano Zürcher, Stefan Zürcher, Charles W Scales, Zohra Fadli, Nicholas D Spencer, Samuele G P Tosatti
Biomaterials used in the ocular environment should exhibit specific tribological behavior to avoid discomfort and stress-induced epithelial damage during blinking. In this study, two macromolecules that are commonly employed as ocular biomaterials, namely, poly(vinylpyrrolidone) (PVP) and hyaluronan (HA), are compared with two known model glycoproteins, namely bovine submaxillary mucin (BSM) and α1-acid glycoprotein (AGP), with regard to their nonfouling efficiency, wettability, and tribological properties when freely present in the lubricant, enabling spontaneous adsorption, and when chemisorbed under low contact pressures...
May 31, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28511543/sterilization-hydration-dehydration-and-tube-fabrication-of-zwitterionic-hydrogels
#5
Xia Han, Hsiang-Chieh Hung, Priyesh Jain, Fang Sun, Xuewei Xu, Wei Yang, Tao Bai, Shaoyi Jiang
Terminal sterilization of hydrogel-based biomaterials is crucial for their clinically relevant applications. The authors synthesized nonfouling zwitterionic hydrogels consisting of carboxybetaine (CB) acrylamide monomer and a carboxybetaine dimethacrylate crosslinker. The mechanical and biological stability of nonfouling hydrogels were investigated using three main terminal sterilization techniques, i.e., steam autoclave, ethylene oxide gas, and gamma irradiation. It was found that CB hydrogels are very stable at high temperature and pressure and in oxidative gas environments without changing their stress, modulus, and nonfouling properties...
May 16, 2017: Biointerphases
https://www.readbyqxmd.com/read/28403612/polymer-coated-ultrastable-and-biofunctionalizable-lanthanide-nanoparticles
#6
Yurong Que, Chun Feng, Guolin Lu, Xiaoyu Huang
Lanthanide-containing nanoparticles (LnNPs), for example, NaYF4, are considered to be one of the most promising platforms for biological and material applications due to their unique and unusual magnetic and upconversion fluorescent properties. However, limited water dispersity, low long-term colloidal stability, and difficulty in further functionalization greatly narrow the scope of their application in the real world. Herein, we report a facile strategy to counter the aforementioned barriers to the expanding use of LnNPs that involves surface-coating the LnNPs with poly(ethylene glycol)-b-poly(pentafluorophenyl methacrylate)/phosphonic acid and subsequently shell cross-linking with NH2-PEG-NH2...
April 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28380299/lipid-layers-on-nanoscale-surface-topography-stability-and-effect-on-protein-adsorption
#7
Irma Liascukiene, Karim El Kirat, Mathieu Beauvais, Svajus J Asadauskas, Jean-François Lambert, Jessem Landoulsi
Herein, we report the coating of a surface with a random nanoscale topography with a lipid film formed by an anchoring stearic acid (SA) monolayer and phospholipid (DPPC) layers. For this purpose, different procedures were used for phospholipid coating, including adsorption from solution, drop deposition, and spin-coating. Our results reveal that the morphology of the obtained lipid films is strongly influenced by the topography of the underlying substrate but also impacted by other factors, including the coating procedure and surface wettability (modulated by the presence of SA)...
May 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28252277/achieving-ultralow-fouling-under-ambient-conditions-via-surface-initiated-arget-atrp-of-carboxybetaine
#8
Daewha Hong, Hsiang-Chieh Hung, Kan Wu, Xiaojie Lin, Fang Sun, Peng Zhang, Sijun Liu, Keith E Cook, Shaoyi Jiang
We achieved ultralow fouling on target surfaces by controlled polymerization of carboxybetaine under ambient conditions. The polymerization process for grafting polymer films onto the surfaces was carried out in air and did not require any deoxygenation step or specialized equipment. This method allows one to conveniently introduce a nonfouling polymer network onto large substrates.
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28147481/a-zwitterionic-shielded-carrier-with-ph-modulated-reversible-self-assembly-for-gene-transfection
#9
Yuju Shih, Antoine Venault, Lemmuel L Tayo, Sheng-Han Chen, Akon Higuchi, Andre Deratani, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Damien Quemener, Yung Chang
Cationic vectors are ideal candidates for gene delivery thanks to their capability to carry large gene inserts and their scalable production. However, their cationic density gives rise to high cytotoxicity. We present the proper designed core-shell polyplexes made of either poly(ethylene imine) (PEI) or poly(2-dimethylamino ethyl methacrylate) (PDMAEMA) as the core and zwitterionic poly(acrylic acid)-block-poly(sulfobetaine methacrylate) (PAA-b-PSBMA) diblock copolymer as the shell. Gel retardation and ethidium bromide displacement assays were used to determine the PEI/DNA or PDMAEMA/DNA complexation...
February 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28053527/fabrication-of-nonfouling-bactericidal-and-bacteria-corpse-release-multifunctional-surface-through-surface-initiated-raft-polymerization
#10
Bailiang Wang, Zi Ye, Yihong Tang, Yuemei Han, Quankui Lin, Huihua Liu, Hao Chen, Kaihui Nan
Infections after surgery or endophthalmitis are potentially blinding complications caused by bacterial adhesion and subsequent biofilm formation on the intraocular lens. Neither single-function anti-adhesion surface nor contacting killing surface can exhibit ideal antibacterial function. In this work, a novel (2-(dimethylamino)-ethyl methacrylate-co-2-methacryloyloxyethyl phosphorylcholine) (p (DMAEMA-co-MPC)) brush was synthesized by "grafting from" method through reversible-addition fragmentation chain transfer polymerization...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28009508/synthesis-and-antibacterial-study-of-sulfobetaine-quaternary-ammonium-modified-star-shaped-poly-2-dimethylamino-ethyl-methacrylate-based-copolymers-with-an-inorganic-core
#11
Yuji Pu, Zheng Hou, Mya Mya Khin, Rubi Zamudio-Vázquez, Kar Lai Poon, Hongwei Duan, Mary B Chan-Park
Cationic polymethacrylates are interesting candidates for bacterial disinfectants since they can be made in large-scale by various well-established polymerization techniques such as atom transfer radical polymerization (ATRP). However, they are usually toxic or ineffective in serum and various strategies to improve their biocompatibility or nonfouling property have often resulted in compromised bactericidal activity. Also, star-shaped polymers are less explored than linear polymers for application as antibacterial compounds...
December 23, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27692715/evaluation-of-modified-stainless-steel-surfaces-targeted-to-reduce-biofilm-formation-by-common-milk-sporeformers
#12
Shivali Jindal, Sanjeev Anand, Kang Huang, Julie Goddard, Lloyd Metzger, Jayendra Amamcharla
The development of bacterial biofilms on stainless steel (SS) surfaces poses a great threat to the quality of milk and other dairy products as the biofilm-embedded bacteria can survive thermal processing. Established biofilms offer cleaning challenges because they are resistant to most of the regular cleaning protocols. Sporeforming thermoduric organisms entrapped within biofilm matrix can also form heat-resistant spores, and may result in a long-term persistent contamination. The main objective of this study was to evaluate the efficacy of different nonfouling coatings [AMC 18 (Advanced Materials Components Express, Lemont, PA), Dursan (SilcoTek Corporation, Bellefonte, PA), Ni-P-polytetrafluoroethylene (PTFE, Avtec Finishing Systems, New Hope, MN), and Lectrofluor 641 (General Magnaplate Corporation, Linden, NJ)] on SS plate heat exchanger surfaces, to resist the formation of bacterial biofilms...
December 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27460261/candle-soot-based-super-amphiphobic-coatings-resist-protein-adsorption
#13
Lars Schmüser, Noemi Encinas, Maxime Paven, Daniel J Graham, David G Castner, Doris Vollmer, Hans Jürgen Butt, Tobias Weidner
Super nonfouling surfaces resist protein adhesion and have a broad field of possible applications in implant technology, drug delivery, blood compatible materials, biosensors, and marine coatings. A promising route toward nonfouling surfaces involves liquid repelling architectures. The authors here show that soot-templated super-amphiphobic (SAP) surfaces prepared from fluorinated candle soot structures are super nonfouling. When exposed to bovine serum albumin or blood serum, x-ray photoelectron spectroscopy and time of flight secondary ion mass spectrometry analysis showed that less than 2 ng/cm(2) of protein was adsorbed onto the SAP surfaces...
September 26, 2016: Biointerphases
https://www.readbyqxmd.com/read/27363527/hierarchical-polymer-coating-for-optimizing-the-antifouling-and-bactericidal-efficacies
#14
Shunjie Yan, Lingjie Song, Zhihong Li, Shifang Luan, Hengchong Shi, Zhirong Xin, Shenghai Li, Yuming Yang, Jinghua Yin
The bacteria-repellent and bactericidal functionalities in a single system are generally need to be carefully optimized in order to obtain the highest antibacterial performance. In this study, the controlled SI-PIMP strategy was developed for creating hierarchical polymer brushes possessing the bacteria-repellent and bactericidal functionalities. To obtain a bactericidal surface with minimal interference to its nonfouling property, optimization studies were conducted by facilely tailoring the surface density of the quaternary ammonium compound moieties through control over the monomer concentration...
October 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27351270/porosity-tuned-chitosan-polyacrylamide-hydrogel-microspheres-for-improved-protein-conjugation
#15
Sukwon Jung, John H Abel, Jesse L Starger, Hyunmin Yi
We report a robust method to manufacture polyacrylamide-based functional hydrogel microspheres with readily tunable macroporous structures by utilizing a simple micromolding-based technique. Specifically, surface tension-induced droplet formation of aqueous solutions of chitosan and acrylamide in 2D-shaped micromolds followed by photoinduced polymerization leads to monodisperse microspheres. Pore sizes of the microspheres can be readily tuned by simple addition of inert long-chain poly(ethylene glycol) porogen at low content in the prepolymer solution...
July 11, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27265149/low-fouling-electrospun-plla-films-modified-with-zwitterionic-poly-sulfobetaine-methacrylate-catechol-conjugates
#16
Wenjing Yang, Harihara S Sundaram, Jean-Rene Ella, Nongyue He, Shaoyi Jiang
UNLABELLED: In this work, we modified a hydrophobic electrospun poly (l-lactic) acid (PLLA) film with poly (sulfobetaine methacrylate) (pSBMA)-catechol conjugates of different molecular weights to improve the biocompatibility of the film. These conjugates were synthesized via atom transfer radical polymerization. They consist of an ultra-low fouling pSBMA zwitterionic polymer with a surface-adhesive catechol moiety. X-ray photoelectron spectroscopy, contact angle and scanning electron microscopy experiments were performed to characterize films before and after modification with pSBMA-catechol conjugates...
August 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27213986/durable-antibacterial-and-nonfouling-cotton-textiles-with-enhanced-comfort-via-zwitterionic-sulfopropylbetaine-coating
#17
Shiguo Chen, Lingjun Yuan, Qingqing Li, Jianna Li, Xingli Zhu, Yongguang Jiang, Ou Sha, Xinhui Yang, John H Xin, Jiangxin Wang, Florian J Stadler, Peng Huang
A rapid, environment-friendly, and cost-effective finishing method has been developed for cotton textiles by using zwitterionic NCO-sulfopropylbetaine as the antibacterial finishing agent through covalent bond. The sulfopropylbetaine-finished cotton textile exhibits durable broad-spectrum antibacterial and nonfouling activity, improved mechanical properties, and enhanced comfort.
July 2016: Small
https://www.readbyqxmd.com/read/27142255/protein-diffusion-characteristics-in-the-hydrogels-of-poly-ethylene-glycol-and-zwitterionic-poly-sulfobetaine-methacrylate-psbma
#18
Jiang Wu, Zecong Xiao, Chaochao He, Jingjing Zhu, Guanglong Ma, Guangzhi Wang, Hongyu Zhang, Jian Xiao, Shengfu Chen
UNLABELLED: Nonfouling materials such as neutral poly(ethylene glycol) (PEG) and zwitterionic poly(sulfobetaine methacrylate) (pSBMA) are ideal biocompatible materials for drug, especially protein drug delivery. The interaction behavior of protein between the nonfouling materials could cause great impact on their future applications, such as controlled release drug delivery systems. In this work, we investigated the diffusion behavior of the fluorescence-labeled model proteins (bovine serum albumin (BSA) and lysozyme (LYZ)) in nonfouling PEG, pSBMA and mixed PEG-SBMA hydrogels (SBMA:PEG 4:1, SBMA:PEG 1:4)...
August 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27090589/ultra-low-fouling-and-high-antibody-loading-zwitterionic-hydrogel-coatings-for-sensing-and-detection-in-complex-media
#19
Ying-Nien Chou, Fang Sun, Hsiang-Chieh Hung, Priyesh Jain, Andrew Sinclair, Peng Zhang, Tao Bai, Yung Chang, Ten-Chin Wen, Qiuming Yu, Shaoyi Jiang
UNLABELLED: For surface-based diagnostic devices to achieve reliable biomarker detection in complex media such as blood, preventing nonspecific protein adsorption and incorporating high loading of biorecognition elements are paramount. In this work, a novel method to produce nonfouling zwitterionic hydrogel coatings was developed to achieve these goals. Poly(carboxybetaine acrylamide) (pCBAA) hydrogel thin films (CBHTFs) prepared with a carboxybetaine diacrylamide crosslinker (CBAAX) were coated on gold and silicon dioxide surfaces via a simple spin coating process...
August 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27063489/achieving-low-fouling-surfaces-with-oppositely-charged-polysaccharides-via-lbl-assembly
#20
Yuping Wei, Hsiang-Chieh Hung, Fang Sun, Tao Bai, Peng Zhang, Ann Kate Nowinski, Shaoyi Jiang
UNLABELLED: The aim of this work is to understand and achieve low fouling surfaces by mixing two oppositely charged polysaccharides through layer-by-layer (LBL) assembly. Diethylaminoethyl-dextran hydrochloride and alginate were employed as a model system to build LBL films. A surface plasmon resonance (SPR) biosensor was used to measure quantitatively the adsorption behavior of charged macromolecules during LBL buildup and the protein adsorption behavior of each deposited bilayer in situ in real time accordingly...
August 2016: Acta Biomaterialia
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