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Steven S Bae, Sonia N Yeung, Clara C Chan
PURPOSE: To report a rare case of filamentary keratitis associated with stiff person syndrome. METHODS: Case report. RESULTS: A 26-year-old woman with several autoimmune conditions was referred because of filamentary keratitis. Conservative management using lubrication, mucolytics, and bandage contact lenses failed to adequately relieve symptoms. Despite the addition of oral prednisone, cyclosporine, and azathioprine, the patient's condition persisted with numerous filaments and severe dry eye...
October 13, 2017: Cornea
Yan Shen, Baihong Yu, Yutao Lv, Bin Li
A running-in and starved lubrication experiment is designed to investigate the heavy-duty scuffing behavior of piston ring coatings against cast iron (Fe) cylinder liner using the piston ring reciprocating liner test rig. The scuffing resistance of the piston ring with the chromium-based ceramic composite coating (CKS), and that with the thermally sprayed nickel-chromium-molybdenum coating (NCM) is compared at different nominal pressures (40~100 MPa) and temperatures (180~250 °C). With the failure time as a criterion, the rank order is as follows: NCM/Fe > CKS/Fe...
October 14, 2017: Materials
Jorge Espina-Casado, Alfonso Fernández-González, Ángel José Del Reguero-Huerga, Humberto Rodríguez-Solla, Marta Elena Díaz-García, Rosana Badía Laíño
One of the main drawbacks in the application of metal oxide nanoparticles as lubricant additives is their poor stability in organic media, despite the good anti-wear, friction-reducing and high load capacity properties described for these materials. In this work, we present a novel procedure to chemically cap the surface of ZrO2 nanoparticles (ZrO2NPs) with long hydrocarbon chains in order to obtain stable dispersions of ZrO2NPs in non-aqueous media without disrupting their attributes as lubricant additives...
October 16, 2017: Nanotechnology
Daniel Wong, Julie M Albietz, Huan Tran, Cimonette Du Toit, Anita Hui Li, Tina Yun, Jee Han, Katrina L Schmid
AIM: Contact lens induced dry eye affects approximately 50% of contact lens wearers. The aim was to assess the effects of Manuka (Leptospermum sp.) honey eye drops (Optimel, Melcare, Australia) on dry eye in contact lens wearers. The safety of the honey eye drops in contact lens wear and contact lens wearers' compliance were also evaluated. DESIGN: Prospective, randomised, cross over study, examiner masked, pilot treatment trial. METHODS: Twenty-four participants aged 20 to 55 years with contact lens related dry eye were recruited and randomised to two treatment groups; 20 completed the study...
October 9, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
Sarah A Flowers, Agata Zieba, Jessica Örnros, Chunsheng Jin, Ola Rolfson, Lena I Björkman, Thomas Eisler, Sebastian Kalamajski, Masood Kamali-Moghaddam, Niclas G Karlsson
Lubricin, a heavily O-glycosylated protein, is essential for boundary lubrication of articular cartilage. Strong surface adherence of lubricin is required given the extreme force it must withstand. Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in osteoarthritis and inflammatory arthritis. This investigation was undertaken to localise COMP-lubricin complexes within cartilage and investigate if other cartilage proteins are involved in anchoring lubricin to the joint...
October 13, 2017: Scientific Reports
Galen H Shi, Sharon L Shinkle, Ganapathy Gopalrathnam, Xia Dong, Jeffrey D Hofer, Eric C Jensen, Natarajan Rajagopalan
The interior surface of prefilled syringes is typically coated with silicone oil for lubrication to aid in free plunger movement. This article discusses the impact and interaction of formulation variables with silicone oil within the interior surface of the barrel. Characterization techniques including syringe glide force, break loose force, ZebraSci imaging, contact angle, ICP, and RapID were used in assessing the interactions. Data indicate formulation variables of pH, buffer and tonicity agent type and concentration and surfactant can impact silicone oil distribution of prefilled syringes leading to changes in functional properties of the syringe over time...
October 12, 2017: PDA Journal of Pharmaceutical Science and Technology
Martin Pumera
Much research effort has been put in to study layered compounds with transition metal dichalcogenides (TMDs) being one of the most studied compounds. Due to their extraordinary properties such as excellent electrochemical properties, tuneable band gaps and low shear resistance due to weak van der Waals interactions between layers, TMDs have been found to have a wide application such as electrocatalyst for hydrogen evolution reactions, supercapacitors, biosensors, field-effect transistors (FETs), photovoltaic and lubricant additives...
October 13, 2017: Chemistry: a European Journal
Shu-Yi Wei, Feng-Yong Li, Qiang Li, Sen-Kai Li, Chuan-De Zhou, Yu Zhou, Yu-Jiao Cao, Si-Ya Zhang, Yang Zhao
BACKGROUND: The inverted peno-scrotal flap method is considered the standard method of vaginoplasty in male-to-female genital reassignment surgery. Though with numerous advantages, the method has its limitations regarding skin texture, lack of inherent lubrication, and that the tissues for creating the labia depend on the amount of tissues remaining after vaginoplasty. Our purpose was to describe the procedure and outcome of vaginoplasty applying a new technique: autologous buccal micro-mucosa free graft combined with posterior scrotal flap transfer, which could solve some of the problems the previous methods had...
October 12, 2017: Aesthetic Plastic Surgery
Theodoros Avgerinos, Nikolaos Kantiranis, Athanasia Panagopoulou, Stavros Malamataris, Kyriakos Kachrimanis, Ioannis Nikolakakis
Objective/Significance: To elucidate the role of plasticizers in different mini matrices and correlate mechanical properties with drug release. METHODS: Cylindrical pellets were prepared by hot-melt extrusion (HME) and mini tablets by hot (HC) and ambient compression (AC). Venlafaxine HCl was the model drug, Eudragit® RSPO the matrix former and citric acid or Lutrol® F127 the plasticizers. The matrices were characterised for morphology, crystallinity and mechanical properties. The influence of plasticizer's type and content on the extrusion pressure (Pe) during HME and ejection during tableting was examined and the mechanical properties were correlated with drug release parameters...
October 12, 2017: Drug Development and Industrial Pharmacy
Elizabeth R Bird, Martin Seehuus, Julia R Heiman, Kelly Cue Davis, Jeanette Norris, William H George
This study examined the dependence of sexual response (vaginal pulse amplitude [VPA] and subjective sexual arousal) on alcohol intoxication (.10% breath alcohol concentration [BrAC] versus no alcohol) and the nature of a woman's currently most upsetting traumatic event (C-MUTE), whether it was sexual (e.g., rape) or nonsexual (e.g., combat). Self-reported sexual outcomes were also compared by C-MUTE type. A total of 117 women completed background measures and either drank alcoholic or nonalcoholic beverages...
October 12, 2017: Journal of Sex Research
Erika Garcia, Patrick T Bradshaw, Ellen A Eisen
Breast cancer is the leading cancer diagnosed among women and environmental studies have produced few leads on modifiable risk factors. Following an Institute of Medicine recommendation for occupational studies of highly exposed women, we took advantage of an existing cohort of 4,503 female hourly autoworkers in Michigan exposed to metalworking fluid (MWF), complex mixtures of oils and chemicals widely used in metal manufacturing worldwide. Cox proportional hazards models were fit to estimate hazard ratios (HR) for incident breast cancer (follow-up 1985-2013) and cumulative exposure (20-year lag) to straight mineral oils (a known human carcinogen), and water-based soluble and synthetic MWF...
August 23, 2017: American Journal of Epidemiology
Zhongwei Li, Xiang Yuan, Xuerong Cui, Xin Liu, Leiquan Wang, Weishan Zhang, Qinghua Lu, Hu Zhu
Welan gum is a kind of novel microbial polysaccharide, which is widely produced during the process of microbial growth and metabolism in different external conditions. Welan gum can be used as the thickener, suspending agent, emulsifier, stabilizer, lubricant, film-forming agent and adhesive usage in agriculture. In recent years, finding optimal experimental conditions to maximize the production is paid growing attentions. In this work, a hybrid computational method is proposed to optimize experimental conditions for producing Welan gum with data collected from experiments records...
2017: PloS One
Guoliang Zhang, Guoxin Xie, Lina Si, Shizhu Wen, Dan Guo
Smart nanocontainers with stimuli-responsive property can be used to fabricate a new kind of self-lubricating nanocomposite, while the practical potential of the metal-organic frameworks (MOFs) as nanocontainers for lubricants has not been realized. In this work, mesoporous Cu-BTC MOFs storing oleylamine nanocomposites were explored from synthesis and microstructure to self-lubricating characterization. The stress stimuli-responsive of the Cu-BTC storing oleylamine (Cu-BTCO) on the lubrication behavior has been investigated by subjecting it to macroscopic ball-on-disc friction tests...
October 10, 2017: ACS Applied Materials & Interfaces
Hoyle L Whiteside, Supawat Ratanapo, Albert Sey, Abdullah Omar, Deepak Kapoor
INTRODUCTION: The efficacy of heparin based flush solutions in rotational atherectomy (RA) has not been validated. Recently, a single center study demonstrated the feasibility of an alternative flush solution with 10,000U of unfractionated heparin (UFH) in 1L of normal saline. We aimed to evaluate the safety and efficacy of an alternative flush solution intermittently utilized at our institution. METHODS: We retrospectively identified 150 patients undergoing RA over a three year period...
August 25, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Yu-En Shih, Yu-Chih Lin, Tse-Yu Chung, Mei-Chun Liu, Guan-Heng Chen, Chia-Chang Wu, Jason T C Tzen
Astringency, a sensory characteristic of food and beverages rich in polyphenols, mainly results from the formation of complexes between polyphenols and salivary proteins, causing a reduction of the lubricating properties of saliva. To develop an in vitro assay to estimate the astringency of oolong tea infusion, artificial oil bodies were constituted with sesame oil sheltered by a modified caleosin fused with histatin 3, one of the human salivary small peptides. Aggregation of artificial oil bodies was induced when they were mixed with oolong tea infusion or its major polyphenolic compound, (-)-epigallocatechin gallate (EGCG) of 100μM as observed in light microscopy...
October 2017: Journal of Food and Drug Analysis
Zhou Yu, Fei Zhang, Jingsong Huang, Bobby G Sumpter, Rui Qiao
Surface forces mediated by room-temperature ionic liquids (RTILs) play an essential role in diverse applications including self-assembly, lubrication, and electrochemical energy storage. Therefore, their fundamental understanding is critical. Using molecular simulations, we study the interactions between two nanorods immersed in model RTILs at rod-rod separations where both structural and double layer forces are important. The interaction force between neutral rods oscillates as the two rods approach each other, similar to the classical structural forces...
October 7, 2017: Journal of Chemical Physics
Nicole Werner, Susanne Zibek
Long-chain α,ω-dicarboxylic acids (DCAs) are versatile chemical intermediates of industrial importance used as building blocks for the production of polymers, lubricants, or adhesives. The majority of industrial long-chain DCAs is produced from petro-chemical resources. An alternative is their biotechnological production from renewable materials like plant oil fatty acids by microbial fermentation using oleogenious yeasts. Oleogenious yeasts are natural long-chain DCA producers, which have to be genetically engineered for high-yield DCA production...
October 5, 2017: World Journal of Microbiology & Biotechnology
Alizeb Hussain Syed, Micael Boulet, Tommaso Melchiori, Jean-Michel Lavoie
In this work, CFD simulations of an air-water bubbling column were performed and validated with experimental data. The superficial gas velocities used for the experiments were 0.019 and 0.038 m/s and were considered as an homogeneous regime. The former involves simpler physics when compared to a heterogeneous regime where the superficial velocities are higher. In order to simulate the system, a population balance model (PBM) was solved numerically using a discrete method and a closure kernels involving the Luo coalescence model as well as two different breakup models: Luo's and Lehr's...
2017: Frontiers in Chemistry
M N Nagornov, E N Leonova, A S Kucha
The objective of the present study was the experimental investigation of the morphological characteristics of the 20 mcl blood droplets which freely fell down onto the surfaces that were either dry or moderately and profusely lubricated with water. The morphological properties of the resulting blood stains on the glass surfaces, dry or moderately and profusely lubricated with water, are described. The most characteristic features of such stains at the wet surface were the uneven serrated and stripe-like prominences, radial 'lucent stripes' passing into the splashing elements...
2017: Sudebno-meditsinskaia Ekspertiza
Leila Pashazanusi, Moses Oguntoye, Shreyas Oak, Julie N L Albert, Lawrence R Pratt, Noshir S Pesika
We present an exploratory study of the tribological properties between an AFM probe and a Au(111) surface in an aqueous environment while subjected to applied surface potentials. Using a three-electrode setup, the electrical potential and interfacial electric field on a Au(111) working electrode are controlled. Lateral force microscopy is used to measure the friction forces between the AFM probe and the Au surface. As the AFM probe approaches the surface, normal forces are also measured to gain insight into the interfacial forces...
October 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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