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Robert Krysiak, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Elevated prolactin levels are associated with sexual dysfunction in women. No previous study has investigated the effect of dopamine agonists on sexual functioning in women. METHODS: The study enrolled 30 young women with mild hyperprolactinemia (serum prolactin levels in the range between 25 and 50 ng/mL), 15 of whom were later treated with bromocriptine (5-10 mg daily), as well as 14 age- and weight-matched healthy women. All women completed a questionnaire evaluating female sexual function (Female Sexual Function Index - FSFI) and a questionnaire evaluating the presence and severity of depressive symptoms (Beck Depression Inventory Second Edition - BDI-II) RESULTS: Women with mild hyperprolactinemia had a lower total FSFI score, lower scores in all domains of sexual functioning (desire, arousal, lubrication, and dyspareunia), as well as a lower total BDI-II score than control women...
February 20, 2018: Pharmacological Reports: PR
Yongkun Xu, Huimin Qi, Guitao Li, Xueping Guo, Yong Wan, Ga Zhang
Polymer composites have a high potential for applications as tribo-materials exposed to sea water owing to their self-lubrication characteristic and high chemical stability. In the present work, tribological behaviors of polyetheretherketone (PEEK) composites rubbing with stainless steel in sea water were explored using a pin-on-disc tribometer integrated with a potentiostat for electrochemical control. It was demonstrated that further adding 5 vol% hexagonal boron nitride (h-BN) nanoparticles into PEEK reinforced with short carbon fibers (SCF) significantly enhanced the wear resistance...
February 13, 2018: Journal of Colloid and Interface Science
Aline Reichert, Michael Seidenstuecker, Rainer Gadow, Hermann O Mayr, Norbert P Suedkamp, Sergio H Latorre, Partick Weichand, Anke Bernstein
Particle-induced periprosthetic osteolysis and subsequent aseptic implant loosening are a major cause of compromising the long-term results of total joint replacements. To date, no implant has been able to mirror radically the tribological factors (friction/lubrication/wear) of in vivo tribological pairings. Carbon-Fibre Reinforced SiC-Composites (C/SiSiC), a material primarily developed for brake technology, has the opportunity to fulfil this requirement. Until now, the material itself has not been used in medicine...
February 22, 2018: Materials
Zhaoxia Li, Shuanhong Ma, Ga Zhang, Daoai Wang, Feng Zhou
Amphiphilic polymer nanospheres of poly (3-Sulfopropyl methacrylate potassium salt -co-styrene) [P(SPMA-co-St)] were prepared by a simple soap-free emulsion polymerization method and used as efficient water lubrication additive to enhance the anti-wear behaviors of Ti6Al4V alloy. The monodisperse and flexible P(SPMA-co-St) bi-component copolymer nanospheres were synthesized with a controllable manner by adjusting the mass fraction ratio of the monomers, with the hydrophobic polystyrene (PSt) as the hard and skeletal carrier component, and the hydrophilic PSPMA with hydration layer structure as the soft lubrication layer in the course of friction...
February 22, 2018: ACS Applied Materials & Interfaces
Vincent J Cornelisse, Christopher K Fairley, Tim R H Read, David Lee, Sandra Walker, Jane S Hocking, Marcus Y Chen, Catriona S Bradshaw, Eric P F Chow
BACKGROUND: Receptive condomless anal sex is a known risk factor for anorectal chlamydia, but it remains unclear whether oro-anal sex practices also contribute. We aimed to determine whether oro-anal sex ("rimming"), fingering or the use of saliva as anal lubricant are risk factors for anorectal chlamydia among men who have sex with men (MSM). METHODS: This cross-sectional study was conducted at Melbourne Sexual Health Centre from July 2014 to June 2015...
January 30, 2018: Sexually Transmitted Diseases
Bien Cuong Tran Khac, Frank William DelRio, Koo-Hyun Chung
Surface damage characteristics of single- and multi-layer hexagonal boron nitride (h-BN), molybdenum disulfide (MoS2 ) and graphene films were systematically investigated via atomic force microscopy (AFM)-based progressive-force and constant-force scratch tests and Raman spectroscopy. The film-to-substrate interfacial strengths of these atomically-thin films were assessed based on their critical forces (i.e., normal force where the atomically-thin film was delaminated from the underlying substrate) as determined from progressive-force scratch tests...
February 21, 2018: ACS Applied Materials & Interfaces
Senol Tonyali, Mehmet Yilmaz
Background/Aims: Interstitial cystitis (IC)/bladder pain syndrome (BPS) is a debilitating disease characterized with urgency, frequency, and pelvic pain affecting especially women. Sexual dysfunction in female patients with IC/BPS consists of dyspareunia, altered sexual desire and orgasm frequency and insufficient lubrication is reported to negatively affect the patient's quality of life. In the present study, we aimed to determine the association between IC/BPS and sexual dysfunction and improvement in sexual dysfunction related to given treatments...
November 2017: Current Urology
Andrea Burri, Hartmut Porst
BACKGROUND: To date, neither the original English nor any of the translated versions of the Sexual Complaints Screener for Women (SCS-W) have been tested for their psychometric properties. AIM: To evaluate the validity and utility of the German version of the SCS-W by assessing content, convergent, and discriminant validity. METHODS: A population sample of 309 women (mean age = 26.9 years) completed the online survey and had matching data available on the SCS-W and the Female Sexual Function Index (FSFI)...
February 17, 2018: Sexual Medicine
Yanan Meng, Jianlin Sun, Ping Wu, Chang Dong, Xudong Yan
In this paper, nano-TiO2lubricating fluid was chosen as an advanced rolling lubricant to investigate its effect on the hot rolled surface and metallographic structure of SS41 steel strips. The tribological performances of nano-TiO2 lubricating fluid were measured by a four-ball tribotester. The hot rolling experiments under different lubrication conditions were carried out by a four-high rolling mill. The surface morphology, oxide scales and metallographic structure after hot rolling were observed using a confocal laser scanning microscope and scanning electron microscope (SEM), respectively...
February 16, 2018: Nanomaterials
Paolo Nicolini, Rosario Capozza, Paolo Restuccia, Tomaš Polcar
Molybdenum disulfide is a well known and effective lubricant, providing extremely low values of the coefficient of friction. It is known that the sliding process may induce structural transformations of amorphous or disordered MoS2 to the crystalline phase with basal planes oriented parallel to the sliding direction, which is optimal for reducing friction. However, the key reaction parameters and conditions promoting this structural transformation are still largely unknown. We investigate, by employing reactive molecular dynamics simulations, the formation of MoS 2 layers from an amorphous phase as a function of temperature, initial sample density and sliding velocity...
February 20, 2018: ACS Applied Materials & Interfaces
Xiaogang Zhang, Yali Zhang, Jianmei Wang, Chenxing Sheng, Zhixiong Li
Sliding friction is a complex phenomenon which arises from the mechanical and molecular interactions of asperities when examined in a microscale. To reveal and further understand the effects of micro scaled mechanical and molecular components of friction coefficient on overall frictional behavior, a hybrid molecular-mechanical model is developed to investigate the effects of main factors, including different loads and surface roughness values, on the sliding friction coefficient in a boundary lubrication condition...
August 1, 2018: Journal of Nanoscience and Nanotechnology
Peter Kämpfer, Hans-Jürgen Busse, Stefanie P Glaeser
A Gram-stain-positive, aerobic, endospore-forming bacterium isolated from a coolant lubricant was studied for its taxonomic allocation. On the basis of 16S rRNA gene sequences, strain KSS164-79T shared highest similarity (92.3-92.4 %) to type strains of the species Marinicrinis sediminis,Paenibacillus dongdonensis, Paenibacillus abyssi and Paenibacillus motobuensis. In phylogenetic trees based on the 16S rRNA gene, strain KSS164-79T always formed a distinct cluster with the type strain of M. sediminis. The fatty acid profile supported the grouping of the strain to the genus Marinicrinis...
February 9, 2018: International Journal of Systematic and Evolutionary Microbiology
Yande Huang, Qinggang Wang, Yongmei Wu
Degradation of an active pharmaceutical ingredient (API), a 2-(3-(1-(4-chlorophenyl)cyclopropyl)-[1,2,4]triazolo[4,3-a]pyridin-8-yl)propan-2-ol hydrochloride salt, was observed in a capsule formulation stressed at 50°C or 40°C/75% relative humidity conditions for one month. Two unknown degradants were identified as cationic pseudodimers of the API via accurate mass liquid chromatography-mass spectrometry and one- and two-dimensional NMR analyses. A plausible degradation pathway of the API was postulated which led to the identification of two key N-oxide degradants in the stressed capsule formulation at trace levels...
February 16, 2018: Journal of Pharmaceutical Sciences
Yasuyuki Yokota, Hiroo Miyamoto, Akihito Imanishi, Kouji Inagaki, Yoshitada Morikawa, Ken-Ichi Fukui
It has been observed that the properties of room temperature ionic liquids near solid substrates are different from those of bulk liquids, and these properties play an important role in the development of catalysts, lubricants, and electrochemical devices. In this paper, we report microscopic studies of ionic liquid/solid interfaces performed using molecular dynamics simulations. The structural and dynamic properties of 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (BMIM-TFSI) on mica and graphite interfaces were thoroughly investigated to elucidate the microscopic origins of the formation of layered structures at the interfaces...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
Nasrin Saharkhiz, Shahrzad Zademodares, Saghar Salehpour, Sedighe Hosseini, Leyla Nazari, Hatav Ghasemi Tehrani
Background: In this study, the effect of testosterone gel administration during ovulation induction on the fertility rate was examined in women with a poor ovarian response in in vitro fertilization (IVF) cycles. Materials and Methods: The current study is a single-blinded, randomized clinical trial. Patients who met inclusion (Bologna) criteria were placed in the antagonist cycle group. The patients were randomly divided into two groups each included 25 participants treated with a placebo (lubricant gel, the controls) and testosterone gel (intervention)...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Begüm Z Özel, Vanessa Sun, Avita Pahwa, Rebecca Nelken, Christina E Dancz
INTRODUCTION AND HYPOTHESIS: The purpose of the study was to determine if there is a difference in pain during and after multichannel urodynamic testing in women when using 2% lidocaine gel versus water-based lubricant. METHODS: This was a randomized, controlled, double-blinded study. Women scheduled to undergo urodynamic testing were invited to participate. Participants were randomized to lidocaine 2% gel or water-based lubricant for use during testing. Both participant and examiner were blinded to the type of gel...
February 17, 2018: International Urogynecology Journal
Flaviana Vieira, Janaina V Guimarães, Marcia C S Souza, Poliana M L Sousa, Rafaela F Santos, Agueda M R Z Cavalcante
OBJECTIVE: To assess the scientific evidence for management and preservation of perineal integrity during the expulsive stage of labor. STUDY DESIGN: Integrative review that employed the Population, Intervention, Comparison, Outcome strategy to formulate the research question: Which perineal measure(s) is(are) effective in maintaining perineal integrity during labor? The search was performed in the databases MEDLINE, LILACS, BDENF and SciELO. The ten selected studies were analyzed based on their level of evidence and grade of recommendation...
February 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Alain Regnier, Iris Berton, Didier Concordet, Jean-Yves Douet
OBJECTIVE: To assess the degree and duration of corneal anaesthesia provided by topical application of a non-ophthalmic 2% lidocaine gel in horses. STUDY DESIGN: Experimental, 'blinded', randomized prospective study. ANIMALS: Twelve adult horses without relevant ocular abnormalities. METHODS: Baseline corneal touch threshold (CTT) measurements were obtained bilaterally by use of a Cochet-Bonnet aesthesiometer just prior to topical treatment...
September 15, 2017: Veterinary Anaesthesia and Analgesia
Antonio Simone Laganà, Salvatore Giovanni Vitale, Lily Stojanovska, Irene Lambrinoudaki, Vasso Apostolopoulos, Benito Chiofalo, Laura Rizzo, Francesca Basile
This single-arm pilot study enrolled 47 post-menopausal women affected by vulvovaginal atrophy (VVA). The Vaginal Health Index Score (VHIS) was evaluated for all women and all completed the Female Sexual Function Index (FSFI) questionnaire at baseline (T0) and after 15 days of vaginal cream treatment with one application per day (T1). Following treatment there was a significant improvement in all VHIS parameters and total score (p < 0.0001). Similarly, there was a significant improvement on four FSFI domains (lubrication, orgasm, satisfaction and pain) and total score (p = 0...
March 2018: Maturitas
Jaeho Jang, Sungbo Heo, Wang Ryeol Kim, Jun-Ho Kim, Dae-Geun Nam, Kwang Ho Kim, Ikmin Park, In-Wook Park
Quinary Ti-B-C-N-Si nanocomposite films were deposited onto AISI 304 substrates using a pulsed d.c. magnetron sputtering system. The quinary Ti-B-C-N-Si (5 at.%) film showed excellent tribological and wear properties compared with those of the Ti-B-C-N films. The steady friction coefficient of 0.151 and a wear rate of 2 × 10-6 mm3N-1m-1 were measured for the Ti-B-C-N-Si films. The oxidation behavior of Ti-B-C-N-Si nanocomposite films was systematically investigated using X-ray diffraction (XRD), and thermal analyzer with differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA)...
March 1, 2018: Journal of Nanoscience and Nanotechnology
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