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zwitterionic polymer

Bowen Li, Zhefan Yuan, Peng Zhang, Andrew Sinclair, Priyesh Jain, Kan Wu, Caroline Tsao, Jingyi Xie, Hsiang-Chieh Hung, Xiaojie Lin, Tao Bai, Shaoyi Jiang
For biotherapeutics that require multiple administrations to fully cure diseases, the induction of undesirable immune response is one common cause for the failure of their treatment. Covalent binding of hydrophilic polymers to proteins is commonly employed to mitigate potential immune responses. However, while this technique is proved to partially reduce the antibodies (Abs) reactive to proteins, it may induce Abs toward their associated polymers and thus result in the loss of efficacy. Zwitterionic poly(carboxybetaine) (PCB) is recently shown to improve the immunologic properties of proteins without inducing any antipolymer Abs against itself...
February 19, 2018: Advanced Materials
Gökhan Kocak, Damla Ülker, Cansel Tuncer, Serife Betül Baker, Vural Bütün
A zwitterionic sulfobetaine-based diblock copolymer was successfully synthesized and used in the preparation and stabilization of Ag nanoparticles (AgNPs). For the related block copolymer, a precursor AB type diblock copolymer was synthesized via atom transfer radical polymerization by using a MPEG-based ATRP macroinitiator and 2-(N-dimethylamino)ethyl methacrylate (DMA) comonomer. Tertiary amine residues of PDMA blocks in poly(ethylene glycol) methyl ether-b-poly[2-(N-diethylamino)ethyl methacrylate] (MPEG-b-PDMA) precursor was then converted to polybetaine structures by reacting with 1,3-propanesultone to obtain poly(ethylene glycol) methyl ether-b-poly[3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonate] (MPEG-b-PβDMA) derivative...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Chong Zhang, Jingsong Yuan, Jianhua Lu, Yingqin Hou, Wei Xiong, Hua Lu
The development of high-performance nonfouling polymer surfaces for implantable medical devices and therapeutic nanomaterials is of great importance. Elaborating the relationship of polymer structural characteristics and the resulted surface properties can offer useful guidance toward ideal biointerfaces. In this work, we investigate the effects of the helical conformation and anchoring orientation of poly(α-amino acid)s (PαAAs) to produce advanced nonfouling surfaces. By using the neutral poly(γ-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)esteryl glutamates) (P(EG3Glu)s) as a model system, the adsorption kinetics are monitored by ex-situ variable angle spectroscopic ellipsometry and in-situ quartz crystal microbalance with dissipation...
February 3, 2018: Biomaterials
Wei Zhang, Zhe Yang, Yair Kaufman, Roy Bernstein
Zwitterion polymers have anti-fouling properties; therefore, grafting new zwitterions to surfaces, particularly as hydrogels, is one of the leading research directions for preventing fouling. Specifically, polyampholytes, polymers of random mixed charged subunits with a net-electric charge, offer a synthetically easy alternative for studying new zwitterions with a broad spectrum of charged moieties. Here, a novel polyampholyte hydrogel was grafted onto the surface of polyethersulfone membrane by copolymerizing a mixture of vinylsulfonic acid (VSA) and [2-(methacryloyloxy)ethyl]trimethylammonium chloride (METMAC) as the negatively and positively charged monomers, respectively, using various monomer ratios in the polymerization solution, and with N,N'-methylenebisacrylamide as the crosslinker...
January 31, 2018: Journal of Colloid and Interface Science
Pengfei Xu, Lei Wu, Liqiu Dong, Xin Xu
This work reports the chemoselective polymerization of polar divinyl monomers, including allyl methacrylate (AMA), vinyl methacrylate (VMA), and 4-vinylbenzyl methacrylate (VBMA), by using simple Lewis pairs comprised of homoleptic rare-earth (RE) aryloxide complexes RE(OAr)₃ (RE = Sc (1), Y (2), Sm (3), La (4), Ar = 2,6-tBu₂C₆H₃) and phosphines PR₃ (R = Ph, Cy, Et, Me). Catalytic activities of polymerizations relied heavily upon the cooperation of Lewis acid and Lewis base components. The produced polymers were soluble in common organic solvents and often had a narrow molecular weight distribution...
February 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Christian Adlhart, Joanna Verran, Nuno F Azevedo, Hulya Olmez, Minna M Keinänen-Toivola, Isabel Gouveia, Luis F Melo, Francy Crijns
The spread of infections in health care environments is a persistent and growing problem in most countries, aggravated by the development of microbial resistance to antibiotics and disinfectants. In addition to indwelling medical devices (implants, catheters, etc.), such infections may also result from adhesion of microbes either to external solid-water interfaces such as shower caps, taps, drains, etc, or to external solid-gas interfaces such as door handles, clothes, curtains, computer keyboards, etc. The latter are the main focus of the present work, where an overview of antimicrobial coatings for such applications is presented...
February 1, 2018: Journal of Hospital Infection
Gonzalo Pérez-Mitta, Waldemar A Marmisolle, Loïc Burr, María Eugenia Toimil-Molares, Christina Trautmann, Omar Azzaroni
During the last decade, nanofluidic devices based on solid-state nanopores and nanochannels have come into scene in materials science and will not leave anytime soon. One of the main reasons for this is the excellent control over ionic transport exerted by such devices that promises further important advances when integrated into more complex molecular devices. As a result, pH, temperature, and voltage-regulated devices have been obtained. However, nowadays, there is still a necessity for molecule-driven nanofluidic devices...
February 5, 2018: Small
Maria Inam, Joseph R Jones, Maria M Pérez-Madrigal, Maria C Arno, Andrew P Dove, Rachel K O'Reilly
A wide range of biorelevant applications, particularly in pharmaceutical formulations and the food and cosmetic industries, require the stabilization of two water-soluble blended components which would otherwise form incompatible biphasic mixtures. Such water-in-water emulsions can be achieved using Pickering stabilization, where two-dimensional (2D) nanomaterials are particularly effective due to their high surface area. However, control over the shape and size of the 2D nanomaterials is challenging, where it has not yet been possible to examine chemically identical nanostructures with the same thickness but different surface areas to probe the size-effect on emulsion stabilization ability...
January 24, 2018: ACS Central Science
Chen-Jung Lee, Haiyan Wu, Yang Hu, Megan Young, Huifeng Wang, Dylan Lynch, Fujian Xu, Hongbo Cong, Gang Cheng
Polyelectrolytes have many important functions in both living organisms and man-made applications. One key property of polyelectrolytes is the ionic conductivity due to their porous networks that allow the transport of water and small molecular solutes. Among polyelectrolytes, zwitterionic polymers have attracted huge attention for applications that involve ion transport in a polyelectrolyte matrix; however, it is still unclear how the functional groups of zwitterionic polymer side chains affect their ion transport and swelling properties...
January 31, 2018: ACS Applied Materials & Interfaces
Youngsuk Jung, Yooseong Yang, Taeyoon Kim, Hyun Suk Shin, Sunghoon Hong, Sungmin Cha, Soonchul Kwon
In capacitive deionization, the salt-adsorption capacity of the electrode is critical for efficient hard water desalination. To improve the water-deionization capacity, the carbon electrode surface can be modified with ion-exchange resins. Herein, we introduce the encapsulation of zwitterionic polymers over activated carbon to provide a resistant barrier that stabilizes the structure of electrode during electrochemical performance and enhances the capacitive deionization efficiency. Compared to conventional activated carbon, the surface-modified activated carbon exhibits significantly enhanced capacitive deionization, with a minimum conductivity of ~43 μS/cm...
January 31, 2018: ACS Applied Materials & Interfaces
Maria Concetta Bruzzoniti, Marta Appendini, Barbara Onida, Michele Castiglioni, Massimo Del Bubba, Lia Vanzetti, Prasanta Jana, Gian Domenico Sorarù, Luca Rivoira
The presence of residual color in treated textile wastewater above the regulation limits is still a critical issue in many textile districts. Innovative, polymer-derived ceramics of the Si-C-O system were here synthesized in order to obtain porous nanocomposite materials where a free carbon phase is dispersed into a silicon carbide/silicon oxycarbide network. The sorbents were comprehensively characterized for the removal of two model water-soluble dyes (i.e., the cation methylene blue and the zwitterion rhodamine B)...
January 30, 2018: Environmental Science and Pollution Research International
Hadas Alon, Chen Stern, Moshe Kirshner, Ofer Sinai, Michal Wasserman, Ryan Selhorst, Raymond Gasper, Ashwin Ramasubramaniam, Todd Emrick, Doron Naveh
Two-dimensional (2D) materials are believed to hold significant promise in nanoscale (opto)electronics. While significant progress has been made in this field over the last decade, the ability to control charge carrier density with high spatial precision remains an outstanding challenge in 2D devices. We present an approach that simultaneously addresses the dual issues of charge-carrier doping and spatial precision based on a functional lithographic resist that employs methacrylate polymers containing zwitterionic sulfobetaine pendent groups for noncovalent surface doping of 2D materials...
January 29, 2018: ACS Nano
Xi Liu, Liying Peng, Jingxin Meng, Zhongpeng Zhu, Bing Han, Shutao Wang
Biomedical materials, such as orthopedic biomaterials, have a great impact on improving life quality and self-esteem of human beings. However, the usage of fixed appliances during dental treatment often increases the difficulty of oral cleaning and enlarges the adhesion opportunity of oral bacteria. Furthermore, the existing anti-adhesion coatings, such as polyethylene glycol derivatives and zwitterionic polymers, have not been universally accepted in the oral environment due to their intrinsic problems. Herein, inspired by the anti-adhesion capability of bovine serum albumin, we report a facile protein-based anti-bacterial surface, showing excellent anti-adhesion performance toward oral bacteria...
January 26, 2018: Nanoscale
Fabian Obstals, Mariia Vorobii, Tomáš Riedel, Andres de Los Santos Pereira, Michael Bruns, Smriti Singh, Cesar Rodriguez-Emmenegger
Nonthrombogenic modifications of membranes for extracorporeal membrane oxygenators (ECMOs) are of key interest. The absence of hemocompatibility of these membranes and the need of anticoagulation of patients result in severe and potentially life-threatening complications during ECMO treatment. To address the lack of hemocompatibility of the membrane, surface modifications are developed, which act as barriers to protein adsorption on the membrane and, in this way, prevent activation of the coagulation cascade...
January 22, 2018: Macromolecular Bioscience
Eun Bi Kang, Jung Eun Lee, Zihnil Adha Islamy Mazrad, Insik In, Ji Hoon Jeong, Sung Young Park
We developed nanoparticles comprising a photothermal dye (IR825)-loaded carbonized zwitterionic polymer [FNP-I] as "switch-on" pH-responsive fluorescence probes to sense intracellular cancer cells and for near-infrared (NIR) controllable photothermal therapy (PTT) in vivo and in vitro. The fluorescent "off" of FNP-I was activated after reaching the cancer cell environment, where the zwitterionic compartment of FNP lost its hydrophobicity to induce PTT-mediated heat release of IR825 under NIR irradiation in the tumor...
January 18, 2018: Nanoscale
Shengwei Xiao, Yanxian Zhang, Mingxue Shen, Feng Chen, Ping Fan, Mingqiang Zhong, Baiping Ren, Jintao Yang, Jie Zheng
Some polyzwitterionic brushes exhibit strong "anti-polyelectrolyte effect" and ionic specificity that make them as versatile platforms to build smart surfaces for many applications. However, the structure-property relationship of zwitterionic polymer brushes still remains to be elucidated. Herein, we aim to study the structural-dependent relationship between different zwitterionic polymers and "anti-polyelectrolyte effect". To this end, a series of polyzwitterionic brushes with different cationic moieties cationic moieties (e...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Thomas James Plegue, Kyle M Kovach, Alex J Thompson, Joseph A Potkay
Blood-material interactions are crucial to the lifetime, safety, and overall success of a blood contacting devices. Hydrophilic polymer coatings have been employed to improve device lifetime by shielding blood contacting materials from the natural foreign body response, primarily the intrinsic pathway of the coagulation cascade. These coatings have the ability to repel proteins, cells, bacteria, and other micro-organisms. Coatings are desired to have long-term stability, so that the nonthrombogenic and nonfouling effects gained are long lasting...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Luís Alves, Björn Lindman, Björn Klotz, Axel Böttcher, Hans-Martin Haake, Filipe E Antunes
HYPOTHESIS: The rheological control of suspensions is of key interest in the formulation design. A chemically cross-linked hydrophobically modified poly(acrylic acid) (HMCL-PAA), used as rheology modifier, is pH sensitive and shows swelling behavior above a critical pH due to the ionization of the acrylic acid groups. At low pH, HMCL-PAA suspensions are liquid and turbid. The binding of surfactants to HMCL-PAA, at low pH conditions, can result in significant changes on rheology and transparency of the polymeric suspensions, due to the swelling of the microgel particles...
November 20, 2017: Journal of Colloid and Interface Science
Zhiyong Guo, Xin Hai, Yiting Wang, Yang Shu, Xuwei Chen, Jian-Hua Wang
A novel zwitterionic polymer ionic liquid functionalized magnetic nanospheres, shortly as Fe3O4@PCL-PILs, is synthesized by grafting ionic liquid VimCOOHBr onto polymer ε-caprolactone (PCL) modified magnetic nanospheres via esterification and surface-initiated free radical polymerization. This established synthesis strategy offers the obtained magnetic nanospheres with well-defined core-corona structure, compact grafting layer, favorable zwitterionic and negative-charged surface, and high magnetic susceptibility...
November 27, 2017: Biomacromolecules
Xuebo Quan, Daohui Zhao, Libo Li, Jian Zhou
Surface functionalization of nanoparticles (NPs) with stealth polymers (e.g., hydrophilic and zwitterionic polymers) has become a common strategy to resist non-specific protein adsorption recently. Understanding the role of surface decoration on NP-biomembrane interactions is of great significance to promote the application of NPs in biomedical fields. Herein, using coarse-grained molecular dynamics (CGMD) simulations, we investigate the interactions between stealth polymer-coated gold nanoparticles (AuNPs) and lipid membranes...
November 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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