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zwitterionic polymer

Huangyong Jiang, Dong Chen, Dongbo Guo, Nan Wang, Yue Su, Xin Jin, Gangsheng Tong, Xinyuan Zhu
Novel "zwitterionic" gold nanorods (Au NRs) were constructed through a facile ligand exchange process between cetyltrimethylammonium bromide (CTAB)-Au NRs and the zwitterionic block polymer {poly(2-methacryloyloxyethyl phosohorylcholine)-b-poly(lipoic methacrylate) (pMPC-b-pLA)}. In vitro, they exhibited low dark cytotoxicity and a high therapeutic efficacy to cancer cells. Their blood circulation half-life in vivo (t1/2, ∼10 h) was 20-fold longer than that of CTAB-Au NRs (t1/2, <30 min). After intravenous administration, they accumulated in tumour sites via an enhanced permeability and retention (EPR) effect and enabled destruction of human xenograft tumours in mice after exposure of the tumour location to NIR laser irradiation at 808 nm...
February 6, 2017: Biomaterials Science
Alexander Esser, Saurabh Belsare, Dominik Marx, Teresa Head-Gordon
We have used the AMOEBA model to simulate the THz spectra of two zwitterionic amino acids in aqueous solution, which is compared to the results on these same systems using ab initio molecular dynamics (AIMD) simulations. Overall we find that the polarizable force field shows promising agreement with AIMD data for both glycine and valine in water. This includes the THz spectral assignments and the mode-specific spectral decomposition into intramolecular solute motions as well as distinct solute-water cross-correlation modes some of which cannot be captured by non-polarizable force fields that rely on fixed partial charges...
February 6, 2017: Physical Chemistry Chemical Physics: PCCP
Michaela Chocholoušková, Martina Komendová, Jiří Urban
In this paper, the concentration of N-isopropylacrylamide in the polymerization mixture has been varied to prepare several polymethacrylate monolithic capillary columns. Polymer monoliths combining N-isopropylacrylamide with zwitterion monomer, as well as various dimethacrylate crosslinking monomers have been prepared and characterized. Uracil, thiourea, phenol, toluene, ethylbenzene, propylbenzene, and butylbenzene have been used to characterize retention of prepared capillary columns in the mobile phases with 40-95% of acetonitrile and at working temperatures ranging from 25 to 60°C...
March 10, 2017: Journal of Chromatography. A
Mohammad-Ali Shahbazi, Patrick Vingadas Almeida, Alexandra Correia, Barbara Herranz-Blanco, Neha Shrestha, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Hélder A Santos
Bioresponsive cytosolic nanobased multidelivery has been emerging as an enormously challenging novel concept due to the intrinsic protective barriers of the cells and hardly controllable performances of nanomaterials. Here, we present a new paradigm to advance nano-in-nano integration technology amenable to create multifunctional nanovehicles showing considerable promise to overcome restrictions of intracellular delivery, solve impediments of endosomal localization and aid effectual tracking of nanoparticles...
February 1, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
Yuju Shih, Antoine Venault, Lemmuel L Tayo, Sheng-Han Chen, Akon Higuchi, Andre Deratani, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Damien Quemener, Yung Chang
Cationic vectors are ideal candidates for gene delivery thanks to their capability to carry large gene inserts and their scalable production. However, their cationic density gives rise to high cytotoxicity. We present the proper designed core-shell polyplexes made of either poly(ethylene imine) (PEI) or poly(2-dimethylamino ethyl methacrylate) (PDMAEMA) as the core and zwitterionic poly(acrylic acid)-block-poly(sulfobetaine methacrylate) (PAA-b-PSBMA) diblock copolymer as the shell. Gel retardation and ethidium bromide displacement assays were used to determine the PEI/DNA or PDMAEMA/DNA complexation...
February 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Zhengzhong Wu, Mengtan Cai, Jun Cao, Jiaxing Zhang, Xianglin Luo
Zwitterionic polymers have unique features, such as good compatibility, and show promise in the application of drug delivery. In this study, the zwitterionic copolymers, poly(ε-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine) with disulfide (PCL-ss-PMPC) or poly(ε-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine) or without disulfide (PCL-PMPC) and with different block lengths in PCL-ss-PMPC, were designed. The designed copolymers were obtained by a combination of ring-opening polymerization and atom transferring radical polymerization...
2017: International Journal of Nanomedicine
Miku Nishida, Tadashi Nakaji-Hirabayashi, Hiromi Kitano, Yoshiyuki Saruwatari, Kazuyoshi Matsuoka
The surface of a titanium (Ti) alloy was modified with a self-assembled monolayer of poly(ethylene glycol) methacrylate phosphate (Phosmer PE). A zwitterionic monomer (carboxymethyl betaine, CMB) could be copolymerized with the surface-bound Phosmer PE due to a flexible linker between the Ti alloy surface and a methacryloyl group of Phosmer PE. The poly(CMB) (PCMB)-modified Ti alloy plate exhibited strong suppression of protein adsorption and cell adhesion, and induced approximately twice the amount of calcium (Ca(2+)) deposition as compared to the unmodified Ti alloy plate...
January 17, 2017: Colloids and Surfaces. B, Biointerfaces
Hsiu-Wen Chien, Po-Hsiu Cheng, Shao-Yung Chen, Jiashing Yu, Wei-Bor Tsai
Antifouling modification technology is developed for many biomedical applications such as blood-contact devices and biosensors. In this work, a photo-reactive polymer containing zwitterionic carboxybetaine groups was prepared by copolymerization of two kinds of methacrylic acids with carboxybetaine and azidoaniline. The carboxybetaine moiety is for low fouling and the azidophenyl moiety is for photo-crosslinking. The synthesized copolymers were coated onto polymeric substrates, and then covalently immobilized on the substrates by exposure to UV radiation...
January 26, 2017: Biomaterials Science
Yuji Higaki, Benjamin Fröhlich, Akihisa Yamamoto, Ryo Murakami, Makoto Kaneko, Atsushi Takahara, Motomu Tanaka
Zwitterionic polymer brushes draw increasing attention not only because of their superhydrophilic, self-cleaning capability but also due to their excellent antifouling capacity. We investigated the ion-specific modulation of the interfacial interaction potential via densely packed, uniform poly(sulfobetaine) brushes. The vertical Brownian motion of a cell-sized latex particle was monitored by microinterferometry, yielding the effective interfacial interaction potentials V(Δh) and the autocorrelation function of height fluctuation...
February 7, 2017: Journal of Physical Chemistry. B
Sunita Sharma, Katelyn M Erickson, Jerry M Troutman
Capsular polysaccharide A (CPSA) is a four-sugar repeating unit polymer found on the surface of the gut symbiont Bacteroides fragilis that has therapeutic potential in animal models of autoimmune disorders. This therapeutic potential has been credited to its zwitterionic character derived from a positively charged N-acetyl-4-aminogalactosamine (AADGal) and a negatively charged 4,6-O-pyruvylated galactose (PyrGal). In this report, using a fluorescent polyisoprenoid chemical probe, the complete enzymatic assembly of the CPSA tetrasaccharide repeat unit is achieved...
20, 2017: ACS Chemical Biology
Caihong Liu, Jongho Lee, Jun Ma, Menachem Elimelech
In this study, we demonstrate a highly antifouling thin-film composite (TFC) membrane by grafting a zwitterionic polymer brush via atom-transfer radical-polymerization (ATRP), a controlled, environmentally benign chemical process. Initiator molecules for polymerization were immobilized on the membrane surface by bioinspired catechol chemistry, leading to the grafting of a dense zwitterionic polymer brush layer. Surface characterization revealed that the modified membrane exhibits reduced surface roughness, enhanced hydrophilicity, and lower surface charge...
February 2, 2017: Environmental Science & Technology
Chao Zhang, Hao-Nan Li, Yong Du, Meng-Qi Ma, Zhi-Kang Xu
Mussel-inspired polydopamine (PDA) coatings have been broadly exploited for constructing functional membrane surfaces. One-step codeposition of PDA with antifouling polymers, especially zwitterionic polymers, has been regarded as a promising strategy for fabricating antifouling membrane surfaces. However, one challenge is that the codeposition is usually a slow process over 10 h or even several days. Herein, we report that CuSO4/H2O2 is able to notably accelerate the codeposition process of PDA with poly(sulfobetaine methacrylate) (PSBMA)...
January 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Natalia Wilkosz, Sami Rissanen, Małgorzata Cyza, Renata Szybka, Maria Nowakowska, Alex Bunker, Tomasz Róg, Mariusz Kepczynski
Uptake of piroxicam, a non-steroidal anti-inflammatory drug, from the intestines after oral intake is limited due to its low solubility and its wide use is associated with several side effects related to the gastrointestinal tract. In this study, all-atom molecular dynamics (MD) simulations and fluorescent spectroscopy were employed to investigate the interaction of piroxicam in neutral, zwitterionic, and cationic forms with lipid bilayers composed of phosphatidylcholine, cholesterol, and PEGylated lipids. Our study was aimed to assess the potential for encapsulation of piroxicam in liposomal carriers and to shed more light on the process of gastrointestinal tract injury by the drug...
January 10, 2017: European Journal of Pharmaceutical Sciences
Emma M Pelegri-O'Day, Samantha J Paluck, Heather D Maynard
Many proteins, especially those used as therapeutics, are unstable to storage and shipping temperatures, leading to increased costs in research and industry. Therefore, the design and synthesis of novel stabilizers is an important area of investigation. Herein we report new degradable polymers that stabilize proteins to environmental stressors such as refrigeration and elevated temperature. Specifically, polycaprolactones with different pendant groups were synthesized and surveyed for their ability to stabilize an important therapeutic protein to storage and shipping conditions...
January 12, 2017: Journal of the American Chemical Society
Yang Hu, Yang Li, Fu-Jian Xu
Because of their biocompatibility, biodegradability, and unique bioactive properties, polysaccharides have been recognized and directly applied as excellent candidates for various biomedical applications. In order to introduce more functionalities onto polysaccharides, various modification methods were applied to improve the physical-chemical and biochemical properties. Grafting polysaccharides with functional polymers with limited reaction sites maximizes the structural integrity. To the best of our knowledge, great efforts have been made by scientists across the world, including our research group, to explore different strategies for the synthesis and design of controllable polymer-grafted polysaccharides...
January 9, 2017: Accounts of Chemical Research
Shrinivas Venkataraman, Jeremy P K Tan, Victor W L Ng, Eddy W P Tan, James L Hedrick, Yi Yan Yang
Introduction of hydrophilic components, particularly amines and zwitterions, onto a degradable polymer platform, while maintaining precise control over the polymer composition, has been a challenge. Recognizing the importance of these hydrophilic residues in multiple aspects of the nanobiomedicine field, herein, a straightforward synthetic route to access well-defined amphiphilic and hydrophilic degradable block copolymers from diethanolamine-derived functional eight-membered N-substituted aliphatic cyclic carbonates is reported...
January 9, 2017: Biomacromolecules
Yuhang Zhou, Junjie Li, Ying Zhang, Dianyu Dong, Ershuai Zhang, Feng Ji, Zhihui Qin, Jun Yang, Fanglian Yao
Prediction of the diffusion coefficient of solute, especially bioactive molecules, in hydrogel is significant in the biomedical field. Considering the randomness of solute movement in a hydrogel network, a physical diffusion RMP-1 model based on obstruction theory was established in this study. The physical properties of the solute and the polymer chain and their interactions were introduced into this model. Furthermore, models RMP-2 and RMP-3 were established to understand and predict the diffusion behaviors of proteins in hydrogel...
January 20, 2017: Journal of Physical Chemistry. B
Yuemei Han, Xu Xu, Junmei Tang, Chenghui Shen, Quankui Lin, Hao Chen
Intraocular lens (IOL) is an efficient implantable device commonly used for treating cataracts. However, bioadhesion of bacteria or residual lens epithelial cells on the IOL surface after surgery causes postoperative complications, such as endophthalmitis or posterior capsular opacification, and leads to loss of sight again. In the present study, zwitterionic polymer brushes were fabricated on the IOL surface via bottom-up grafting procedure. The attenuated total reflection-Fourier transform infrared and contact angle measurements indicated successful surface modification, as well as excellent hydrophilicity...
2017: International Journal of Nanomedicine
Yiman Zhao, Yajing Chen, Zhichao Xiong, Xudong Sun, Quanqing Zhang, Yangyang Gan, Lingyi Zhang, Weibing Zhang
In consideration of the close connection between glycopeptides and human diseases, the efficient method to separate and enrich glycopeptides from complex biological samples is urgently required. In the work, we developed a magnetic zwitterionic-hydrophilic material for highly effective separation and analysis of glycopeptides from complex samples. The Fe3O4 particles were covered with a thick layer of polymer by one-step reflux-precipitation polymerization (RPP), subsequently decorated by Au nanoparticles (Au NPs) through in situ reduction and finally modified with zwitterionic groups...
January 27, 2017: Journal of Chromatography. A
Constain H Salamanca, Duvan F Castillo, Juan D Villada, Gustavo R Rivera
Biocompatible polymeric materials with the potential to form functional structures, in association with different therapeutic molecules, in physiological media, represent a great potential for biological and pharmaceutical applications. Therefore, here the formation of a nano-complex between a synthetic cationic polymer and model drug (ampicillin trihydrate) was studied. The formed complex was characterized by size and zeta potential measurements, using dynamic light scattering and capillary electrophoresis...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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