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zwitterionic polymer

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https://www.readbyqxmd.com/read/29902594/characterization-of-clinically-relevant-model-bacterial-strains-of-pseudomonas-aeruginosa-for-anti-biofilm-testing-of-materials
#1
Olena Rzhepishevska, Nataliia Limanska, Mykola Galkin, Alicia Lacoma, Margaretha Lundquist, Dmytro Sokol, Shoghik Hakobyan, Anders Sjöstedt, Cristina Prat, Madeleine Ramstedt
There is a great interest in developing novel anti-biofilm materials in order to decrease medical device-associated bacterial infections causing morbidity and high healthcare costs. However, the testing of novel materials is often done using bacterial lab strains that may not exhibit the same phenotype as clinically relevant strains infecting medical devices. Furthermore, no consensus of strain selection exists in the field, making results very difficult to compare between studies. In this work, 19 clinical isolates of Pseudomonas aeruginosa originating from intubated patients in an intensive care unit have been characterized and compared to the lab reference strain PAO1 and a rmlC lipopolysaccharide mutant of PAO1...
June 11, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29898600/multistimuli-responsive-fluorescent-switches-based-on-spirocyclic-meisenheimer-compounds-smart-molecules-for-the-design-of-optical-probes-and-electrochromic-materials
#2
Marc Villabona, Marina Benet, Silvia Mena, Rabih O Al-Kaysi, Jordi Hernando, Gonzalo Guirado
Fluorescent switches based on spirocyclic zwitterionic Meisenheimer (SZMC) complexes are stimuli-responsive organic molecules with application in a variety of areas. To expand their functionality, novel switching mechanisms are herein reported for these systems: (a) acid- and redox-triggered formation of an additional protonation state with distinct optical properties, and (b) solvent-induced fluorescence modulation. We demonstrate that these new features, which enable both multistimuli and multistate operation of SZMC switches, can be exploited in the preparation of smart organic materials: wide-range pH optical probes, electrochromic and electrofluorochromic films, and polymer-based fluorescent detectors of organic liquids...
June 13, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29893448/combining-fullerenes-and-zwitterions-in-non-conjugated-polymer-interlayers-to-raise-solar-cell-efficiency
#3
Yao Liu, Madhu Sheri, Marcus D Cole, Todd Emrick, Thomas P Russell
Polymer zwitterions were synthesized by nucleophilic ring-opening of 3,3'-(but-2-ene-1,4-diyl)bis(1,2-oxathiolane 2,2-dioxide) (a bis-sultone) with functional perylene diimide (PDI) or fullerene monomers. Integration of these polymers into solar cell devices as cathode interlayers boosted efficiencies of fullerene-based organic photovoltaics (OPVs) from 2.75% to 10.74%, and of non-fullerene-based OPVs from 4.25% to 10.10%, demonstrating the versatility of these interlayer materials in OPVs. The fullerene-containing polymer zwitterion (C60-PZ) showed a higher interfacial dipole (∆) value and electron mobility than its PDI counterpart (PDI-PZ), affording solar cells with high efficiency...
June 12, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29888351/bulk-properties-of-aqueous-graphene-oxide-and-reduced-graphene-oxide-with-surfactants-and-polymers-adsorption-and-stability
#4
Thomas M McCoy, Liliana de Campo, Anna V Sokolova, Isabelle Grillo, Ekaterina I Izgorodina, Rico F Tabor
A diverse range of molecular surfactants and polymers have been incorporated into aqueous graphene oxide (GO) and reduced graphene oxide (rGO) dispersions in order to understand the complex relationship between surface chemistry, surface forces and interfacial thermodynamics of these materials with typical amphiphiles. Surfactant additives were systematically varied in terms of their charge and hydrophobicity to reveal important structure-function relationships affecting adsorption and interaction with GO and rGO surfaces...
June 11, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29879552/structure-function-study-of-poly-sulfobetaine-3-4-ethylenedioxythiophene-psbedot-and-its-derivatives
#5
Chen-Jung Lee, Huifang Wang, Megan Young, Shengxi Li, Fang Cheng, Hongbo Cong, Gang Cheng
Poly(3,4-ethylenedioxythiophene) (PEDOT) has been widely studied in recent decades due to its high stability, biocompatibility, low redox potential, moderate band gap, and optical transparency in its conducting state. However, for its long-term in vivo applications, the biocompatibility of PEDOT still need to be improved. To address this challenge, zwitterionic Poly(sulfobetaine 3,4-ethylenedioxythiophene) (PSBEDOT) that contains EDOT backbone with sulfobetaine functional side chains were developed in our previous study...
June 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29801414/antibody-binding-anti-fouling-surface-coatings-based-on-recombinant-expression-of-zwitterionic-ek-peptides
#6
Julia Ann-Therease Walker, Kye J Robinson, Christopher Munro, Thomas Gengenbach, David A Muller, Paul R Young, Linda Hl Lua, Simon Robert Corrie
Development of anti-fouling films which selectively capture or target proteins of interest is essential for controlling interactions at the "bio/nano" interface. However, in order to synthesise bio-functional films from synthetic polymers that incorporate chemical "motifs" for surface immobilization, anti-fouling, and oriented biomolecule attachment, multiple reaction steps need to be carried out at the solid/liquid interface. EKx is a zwitterionic peptide that has previously been shown to have excellent anti-fouling properties...
May 25, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29792033/psbma-conjugated-magnetic-nanoparticles-for-selective-igg-separation
#7
Fang Cheng, Chuanlei Zhu, Wei He, Jing Zhao, Jingping Qu
Two types of zwitterionic polymer-modified magnetic nanoparticles (NPs) are fabricated by conjugating pSBMA onto PEI-precoated NPs via either one-step method (1S NPs) or two-step method (2S NPs). For both methods, divinyl sulfone is used as linker molecule. Although 1S NPs were capable of resisting both IgG and BSA, 2S NPs exhibited specificity toward IgG adsorption in complex biological fluids, e.g. mixture of serums and IgG. The moderate interactions (Kd ~1.2 µM) between IgG and 2S NPs are three orders of magnitude lower than IgG binding with Protein A (Kd 10nM)...
May 24, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29787247/enhanced-photogeneration-of-reactive-oxygen-species-and-targeted-photothermal-therapy-of-c6-glioma-brain-cancer-cells-by-folate-conjugated-gold-photoactive-polymer-nanoparticles
#8
Jaber Keyvan Rad, Ali Reza Mahdavian, Samideh Khoei, Sakine Shirvalilou
Tumor-selective photodynamic therapy is a successful method for ablation of malignant and cancerous cells. Herein, we introduce the design and preparation of functionalized acrylic copolymer nanoparticles with spiropyran (SP) and imidazole groups through a facile semi-continuous emulsion polymerization. Then, Au3+ ions were immobilized and reduced on their surface to obtain photoresponsive gold-decorated polymer nanoparticles (PGPNPs). The prepared PGPNPs were surface-modified with folic acid as a site-specific tumor cell targeting agent and improve intracellular uptake via endocytosis...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29744504/functionalized-2d-nanomaterials-with-switchable-binding-to-investigate-graphene-bacteria-interactions
#9
Kok H Tan, Shabnam Sattari, Ievgen S Donskyi, Jose L Cuellar-Camacho, Chong Cheng, Karin Schwibbert, Andreas Lippitz, Wolfgang E S Unger, Anna Gorbushina, Mohsen Adeli, Rainer Haag
Graphene and its derivatives have recently attracted much attention for sensing and deactivating pathogens. However, the mechanism of multivalent interactions at the graphene-pathogen interface is not fully understood. Since different physicochemical parameters of graphene play a role at this interface, control over graphene's structure is necessary to study the mechanism of these interactions. In this work, different graphene derivatives and also zwitterionic graphene nanomaterials (ZGNMs) were synthesized with defined exposure, in terms of polymer coverage and functionality, and isoelectric points...
May 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/29737831/investigation-on-the-linker-length-of-synthetic-zwitterionic-polypeptides-for-improved-nonfouling-surfaces
#10
Chong Zhang, Jianhua Lu, Yingqin Hou, Wei Xiong, Kai Sheng, Hua Lu
Zwitterionic polymers are outstanding nonfouling materials widely used for surface modification. However, works that systematically evaluate the structure-activity relationship of the side chain linker effect with related antifouling abilities are sparse. Here, we generate a series of well-defined zwitterionic polypeptides bearing oligoethylene glycol (EG) linkers in the side chain (P(CB-EGx Glu), x = 1-3) and anchor them on gold surfaces via the grafting-to approach to compare their antifouling performances...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29733605/effect-of-surface-hydration-on-antifouling-properties-of-mixed-charged-polymers
#11
Chuan Leng, Hao Huang, Kexin Zhang, Hsiang-Chieh Hung, Yao Xu, Yaoxin Li, Shaoyi Jiang, Zhan Chen
Interfacial water structure on a polymer surface in water (or surface hydration) is related to the antifouling activity of the polymer. Zwitterionic polymer materials exhibit excellent antifouling activity due to their strong surface hydration. It was proposed to replace zwitterionic polymers using mixed charged polymers because it is much easier to prepare mixed charged polymer samples with much lower costs. In this study, using sum frequency generation (SFG) vibrational spectroscopy, we investigated interfacial water structures on mixed charged polymer surfaces in water, and how such structures change while exposing to salt solutions and protein solutions...
May 7, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29728047/label-free-specific-detection-and-collection-of-c-reactive-protein-using-zwitterionic-phosphorylcholine-polymer-protected-magnetic-nanoparticles
#12
Sana Iwasaki, Hideya Kawasaki, Yasuhiko Iwasaki
In this study, poly[2-methacryloyloxyethyl phosphorylcholine (MPC)]-protected Fe3O4 nanoparticles were prepared and used for the label-free specific detection and collection of an acute inflammation marker, C-reactive protein (CRP), in a simulated body fluid. The Fe3O4 nanoparticle surface was modified using poly(MPC) by surface-initiated atom transfer radical polymerization. The density of poly(MPC) was 0.16 chains/nm2, and the colloidal stability of the nanoparticles in aqueous media and human plasma was effectively improved by surface modification...
May 4, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29707870/polypeptide-with-high-zwitterion-density-for-safe-and-effective-therapeutics
#13
Peng Zhang, Priyesh Jain, Caroline Tsao, Zhefan Yuan, Wenchen Li, Bowen Li, Kan Wu, Hsiang-Chieh Hung, Xiaojie Lin, Shaoyi Jiang
Stealth materials are widely used in nano-formulations to improve the performance of therapeutics. As the current "gold standard", poly(ethylene glycol) (PEG) polymer effectively promotes the pharmacokinetics of veiled therapeutic cargos while reducing their immune responses. However, recent studies suggested that the usage of PEG could induce adverse reactions, including the emergence of anti-PEG antibodies and PEG-induced tissue histologic changes, therefore casting a shadow over its future therapeutic applications...
April 29, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29701456/clickable-zwitterionic-co-polymer-capped-quantum-dots-for-in-vivo-fluorescence-tumor-imaging
#14
Laura Trapiella-Alfonso, Thomas Pons, Nicolas Lequeux, Ludovic Leleu, Juliette Grimaldi, Mariana Tasso, Edward Oujagir, Johanne Seguin, Fanny d'Orlyé, Christian Girard, Bich-Thuy Doan, Anne Varenne
In the last decades, fluorescent quantum dots have appeared as high-performance biological fluorescent nanoprobes and have been explored for a variety of biomedical optical imaging applications. However many central challenges still exist concerning the control of the surface chemistry in order to ensure high biocompatibility, low toxicity, anti-fouling and specific active targeting properties. Regarding in vivo applications, circulation time and clearance of the nanoprobe are also key parameters to control for the design and characterization of new optical imaging agents...
April 27, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29692174/ph-responsive-zwitterionic-copolymer-dha-pblg-pcb-for-targeted-drug-delivery-a-computer-simulation-study
#15
Lingxia Hao, Lin Lin, Jian Zhou
In this work, the self-assembled behaviors of zwitterionic copolymer docosahexaenoic acid- b-poly(γ-benzyl-l-glutamate)- b-poly(carboxybetaine methacrylate) (DHA-PBLG-PCB) and the loading and release mechanism of the anticancer drug doxorubicin (DOX) was investigated via computer simulations. The effects of polymer concentration, drug content, and pH on polymeric micelles were explored by dissipative particle dynamics (DPD) simulations. Simulation results show that DHA-PBLG15 -PCB10 can self-assemble into core-shell micelles; in addition, the drug-loaded micelles have a pH-responsive feature...
May 8, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29689159/polycation-interactions-with-zwitterionic-phospholipid-monolayers-on-oil-nanodroplet-suspensions-in-water-d-2-o-probed-by-sum-frequency-scattering
#16
Laura L Olenick, Julianne M Troiano, Nikolay Smolentsev, Paul E Ohno, Sylvie Roke, Franz M Geiger
By combining dynamic light scattering (DLS) measurements with the interface and bond specificity of vibrational sum frequency generation scattering (SFS) spectroscopy, we probe several structural aspects of how zwitterionic DMPC lipids adsorbed to oil droplets suspended in water (D2 O) respond to the presence of the common polycation poly(allylamine hydrochloride) (PAH) in the presence of low and high salt concentration. We show that the polycation interactions with the lipids generally result in two distinct outcomes that depend upon salt and PAH concentration, identified here as Scheme 1 (observed under conditions of high salt concentration) and Scheme 2 (observed under conditions of low salt concentration)...
May 17, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29688620/zwitterionic-polymer-design-that-inhibits-aggregation-and-facilitates-insulin-refolding-mechanistic-insights-and-importance-of-hydrophobicity
#17
Robin Rajan, Yu Suzuki, Kazuaki Matsumura
The synthesis of a zwitterionic polymer, poly-sulfobetaine (poly-SPB), which shows remarkable efficiency in the suppression of insulin aggregation is described. Hydrophobic modification of the polymer results in almost complete inhibition at very low polymer concentrations. Further studies reveal that these polymers facilitate the complete retention of insulin's secondary structure, which is otherwise lost after incubation. Refolding studies show that addition of polymers to preaggregated insulin sample leads to the refolding of denatured insulin, indicating their potential to facilitate the refolding of the denatured proteins...
June 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29674045/preparation-and-evaluation-of-open-tubular-capillary-columns-modified-with-metal-organic-framework-incorporated-polymeric-porous-layer-for-liquid-chromatography
#18
Manman Zhu, Lingyi Zhang, Zhanying Chu, Shulei Wang, Kai Chen, Weibing Zhang, Fan Liu
An open tubular capillary liquid phase chromatographic column (1 m × 25 µm i.d.× 375 µm o.d.) was prepared by incorporating metal organic framework particles modified with vancomycin directly into zwitterionic polymer coating synthesized by the copolymerization of [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide and N,N'-methylenebisacrylamide. The incorporation of IRMOF-3 (isoreticular metal organic framework-3) particles improved selectivity of zwitterionic polymer coating with absolute column efficiency reaching 79900 plates for p-xylene...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29671565/perylene-diimide-based-zwitterion-as-the-cathode-interlayer-for-high-performance-nonfullerene-polymer-solar-cells
#19
Changjian Song, Xiaohui Liu, Xiaodong Li, Ying-Chiao Wang, Li Wan, Xiaohua Sun, Wenjun Zhang, Junfeng Fang
Nonfullerene polymer solar cells (PSCs) have earned widespread and intense interest on account of their properties such as tunable energy levels, potential for low-cost production processes, reduced energy losses, and strong light absorption coefficients. Here, a water-/alcohol-soluble zwitterion perylene diimide zwitterion (PDI-z) consisted of sulfobetaine ion as a terminal substituent and PDI as a conjugated core was synthesized. PDI-z was employed as an electron-transport layer (ETL) for nonfullerene PSC devices, obtaining an optimal power conversion efficiency (PCE) above 11...
May 2, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29652833/a-lipophilic-ir-780-dye-encapsulated-zwitterionic-polymer-lipid-micellar-nanoparticle-for-enhanced-photothermal-therapy-and-nir-based-fluorescence-imaging-in-a-cervical-tumor-mouse-model
#20
Santhosh Kalash Rajendrakumar, Ning-Chu Chang, Adityanarayan Mohapatra, Saji Uthaman, Byeong-Il Lee, Wei-Bor Tsai, In-Kyu Park
To prolong blood circulation and avoid the triggering of immune responses, nanoparticles in the bloodstream require conjugation with polyethylene glycol (PEG). However, PEGylation hinders the interaction between the nanoparticles and the tumor cells and therefore limits the applications of PEGylated nanoparticles for therapeutic drug delivery. To overcome this limitation, zwitterionic materials can be used to enhance the systemic blood circulation and tumor-specific delivery of hydrophobic agents such as IR-780 iodide dye for photothermal therapy...
April 13, 2018: International Journal of Molecular Sciences
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