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zwitterionic polymer

Yichuan Hu, Bo Liang, Lu Fang, Guanglong Ma, Guang Yang, Qin Zhu, Shengfu Chen, Xuesong Ye
In this work, a versatile fabrication method of coating enzyme-based biosensors with ultra-thin antifouling zwitterionic polymer films to meet the challenge of the long-time stability of sensors in vivo was developed. Electrochemically mediated atom transfer radical polymerization (eATRP) was applied to polymerize zwitterionic sulfobetaine methacrylate (SBMA) monomers on the rough enzyme-absorbed electrode surfaces, meanwhile a refined overall bromination was developed to improve the coverage of polymers on the biosensor surfaces, and maintain the enzyme activity simultaneously for the first time...
October 18, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Nathaniel Charles Wardrip, Melissa Dsouza, Meltem Urgun-Demirtas, Seth W Snyder, Jack A Gilbert, Christopher J Arnusch
Understanding and restricting microbial surface attachment will enhance wastewater treatment with membranes. We report a maskless lithographic patterning technique for the generation of patterned polymer coatings on ultrafiltration membranes. Polyethylene glycol, zwitterionic, or negatively charged hydrophilic polymer compositions in parallel- or perpendicular-striped patterns with respect to feed flow were evaluated using wastewater. Membrane fouling was dependent on the orientation and the chemical composition of the coatings...
October 17, 2016: ACS Applied Materials & Interfaces
Yuka Kobayashi, Takeshi Terauchi, Satoshi Sumi, Yoshitaka Matsushita
Metallic conduction generally requires high carrier concentration and wide bandwidth derived from strong orbital interaction between atoms or molecules. These requisites are especially important in organic compounds because a molecule is fundamentally an insulator; only multi-component salts with strong intermolecular interaction-namely, only charge transfer complexes and conducting polymers-have demonstrated intrinsic metallic behaviour. Herein we report a single-component electroactive molecule, zwitterionic tetrathiafulvalene(TTF)-extended dicarboxylate radical (TED), exhibiting metallic conduction even at low temperatures...
October 10, 2016: Nature Materials
Tat'yana A Peganova, Iana S Sinopalnikova, Alexander S Peregudov, Ivan V Fedyanin, Albert Demonceau, Nikolai A Ustynyuk, Alexander M Kalsin
Novel half-sandwich 18ē and 16ē arene ruthenium iminophosphonamide complexes [(η(6)-C6Me6)RuCl{(R'N)2PR2}] (3a-c) and [(η(6)-C6Me6)Ru{(R'N)2PR2}](+)(X(-)) (4a-c) (a, R = Ph, R' = p-Tol; b, R = Et, R' = p-Tol; c, R = Ph, R' = Me. X = BF4, PF6 or BAr(F)4) were synthesized. The elongated Ru-Cl bond in the 18ē complexes is shown to dissociate even in apolar solvents to form the corresponding 16ē cations, which can be readily isolated as salts with non-coordinating anions. The coordinatively unsaturated 16ē complexes are stable species due to efficient π-electron donation from the nitrogen atoms of the zwitterionic NPN-ligand...
October 4, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Hana Vaisocherová-Lísalová, František Surman, Ivana Víšová, Milan Vala, Tomáš Špringer, Maria Laura Ermini, Hana Šípová, Petr Šedivák, Milan Houska, Tomáš Riedel, Ognen Pop-Georgievski, Eduard Brynda, Jiří Homola
Functional polymer coatings that combine the ability to resist nonspecific fouling from complex media with high biorecognition element (BRE) immobilization capacity represent an emerging class of new functional materials for a number of bioanalytical and biosensor technologies for medical diagnostics, security, and food safety. Here, we report on a random copolymer brush surface - poly(CBMAA-ran-HPMAA) - providing high BRE immobilization capacity while simultaneously exhibiting ultralow-fouling behavior in complex food media...
October 14, 2016: Analytical Chemistry
Stefanie C Lange, Esther van Andel, Maarten M J Smulders, Han Zuilhof
To enhance the sensitivity and selectivity of surface-based (bio)sensors, it is of crucial importance to diminish background signals that arise from the nonspecific binding of biomolecules, so-called biofouling. Zwitterionic polymer brushes have been shown to be excellent antifouling materials. However, for sensing purposes, antifouling does not suffice but needs to be combined with the possibility to efficiently modify the brush with recognition units. So far this has been achieved only at the expense of either antifouling properties or binding capacity...
October 11, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Saurabh Das, Byoung Hoon Lee, Roscoe T H Linstadt, Keila Cunha, Youli Li, Yair Kaufman, Zachary A Levine, Bruce H Lipshutz, Roberto D Lins, Joan-Emma Shea, Alan J Heeger, B Kollbe Ahn
Despite the need for molecularly smooth self-assembled monolayers (SAMs) on silicon dioxide surfaces (the most common dielectric surface), current techniques are limited to nonideal silane grafting. Here, we show unique bioinspired zwitterionic molecules forming a molecularly smooth and uniformly thin SAM in "water" in <1 min on various dielectric surfaces, which enables a dip-coating process that is essential for organic electronics to become reality. This monomolecular layer leads to high mobility of organic field-effect transistors (OFETs) based on various organic semiconductors and source/drain electrodes...
October 12, 2016: Nano Letters
Kristopher W Kolewe, Kerianne M Dobosz, Katrina A Rieger, Chia-Chih Chang, Todd Emrick, Jessica D Schiffman
In this study, we exploit the excellent fouling resistance of polymer zwitterions and present electrospun nanofiber mats surface functionalized with poly(2-methacryloyloxyethyl phosphorylcholine) (polyMPC). This zwitterionic polymer coating maximizes the accessibility of the zwitterion to effectively limit biofouling on nanofiber membranes. Two facile, scalable methods yielded a coating on cellulose nanofibers: (i) a two-step sequential deposition featuring dopamine polymerization followed by the physioadsorption of polyMPC, and (ii) a one-step codeposition of polydopamine (PDA) with polyMPC...
October 6, 2016: ACS Applied Materials & Interfaces
Allen O Osaheni, Eric B Finkelstein, Patrick T Mather, Michelle M Blum
: Hydrogels display a great deal of potential for a wide variety of biomedical applications. Often times the performance of these biomimetic materials is limited due to inferior friction and wear properties. This manuscript presents a method inspired by the tribological phenomena observed in nature for enhancing the lubricious properties of poly (vinyl alcohol) (PVA) hydrogels. This was achieved by blending PVA with various amounts of zwitterionic polymer, poly ([2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide)) (pMEDSAH)...
September 17, 2016: Acta Biomaterialia
Andrei Yu Kostritskii, Diana A Kondinskaia, Alexey M Nesterenko, Andrey A Gurtovenko
Although synthetic cationic polymers represent a promising class of effective antibacterial agents, the molecular mechanisms behind their antimicrobial activity remain poorly understood. To this end, we employ atomic-scale molecular dynamics simulations to explore adsorption of several linear cationic polymers of different chemical structure and protonation (polyallylamine (PAA), polyethylenimine (PEI), polyvinylamine (PVA), and poly-l-lysine (PLL)) on model bacterial membranes (4:1 mixture of zwitterionic phosphatidylethanolamine (PE) and anionic phosphatidylglycerol (PG) lipids)...
October 11, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Simona Janků, Martina Komendová, Jiří Urban
Porous polymer monoliths have been used to develop an online solid-phase extraction with liquid chromatography method for determination of dopamine in urine as well as for a continuous monitoring of dopamine in flowing system. A polymerization mixture containing 4-vinylphenylboronic acid monomer has been used to prepare a trapping column based on specific ring formation reaction with dopamine cis-diol functionality. Additionally, a monolithic stationary phase with zwitterion functionality has been used to prepare capillary column for the separation of dopamine...
September 4, 2016: Journal of Separation Science
J P Mahalik, M Muthukumar
Using the Langevin dynamics method and a coarse-grained model, we have studied the formation of vesicles by hydrophobic polymers consisting of periodically placed zwitterion side groups in dilute salt-free aqueous solutions. The zwitterions, being permanent charge dipoles, provide long-range electrostatic correlations which are interfered by the conformational entropy of the polymer. Our simulations are geared towards gaining conceptual understanding in these correlated dipolar systems, where theoretical calculations are at present formidable...
August 21, 2016: Journal of Chemical Physics
Nicolas P Martin, Clément Falaise, Christophe Volkringer, Natacha Henry, Pierre Farger, Camille Falk, Emilie Delahaye, Pierre Rabu, Thierry Loiseau
Four uranyl-bearing coordination polymers (1-4) have been hydrothermally synthesized in the presence of the zwitterionic 1,3-bis(carboxymethyl)imidazolium (= imdc) anion as organic linkers after reaction at 150 °C. At low pH (0.8-3.1), the form 1 ((UO2)2(imdc)2(ox)·3H2O; ox stands for oxalate group) has been identified. Its crystal structure (XRD analysis) consists of the 8-fold-coordinated uranyl centers linked to each other through the imdc ligand together with oxalate species coming from the partial decomposition of the imdc molecule...
September 6, 2016: Inorganic Chemistry
Metin Atila, George Katselis, Paulos Chumala, Yu Luo
Phospholipids generally dominate in bacterial lipids. The negatively charged nature of phospholipids renders bacteria susceptible to cationic antibiotic peptides. In comparison with Gram-negative bacteria, Gram-positive bacteria in general have much less zwitterionic phosphatidylethanolamine. However, they are known for producing aminoacylated phosphatidylglycerol (PG), especially positively charged L-lysyl-PG, which is catalyzed by lysyl-PG synthase MprF, which appears to have a broad range of specificity for L-aminoacyl transfer RNAs...
October 2016: Journal of the American Society for Mass Spectrometry
Maxime Leroux, Nicolas Mercier, Magali Allain, Marie-Claire Dul, Jens Dittmer, Abdel Hadi Kassiba, Jean-Pierre Bellat, Guy Weber, Igor Bezverkhyy
The zwitterionic bipyridinium carboxylate ligand 1,1'-bis(4-carboxyphenyl)-4,4'-bipyridinium (pc1) in the presence of cadmium chloride affords novel porous coordination polymers (PCPs): [Cd4(pc1)3Cl6]·CdCl4·guest (1) crystallizing in the P3̅1c space group. In the structure, [Cd4Cl6(CO2)6] building units are linked together by six pc1 ligands, leading to a 3D high-symmetrical network exhibiting hexagonal channels along the c axis. The walls of this PCP consist of cationic electron-acceptor bipyridinium units...
September 6, 2016: Inorganic Chemistry
Jianxi Liu, Kaiguang Yang, Wenya Shao, Senwu Li, Qi Wu, Shen Zhang, Yanyan Qu, Lihua Zhang, Yukui Zhang
Because of the low abundance of glycopeptide in natural biological samples, methods for efficient and selective enrichment of glycopeptides play a significant role in mass spectrometry (MS)-based glycoproteomics. In this study, a novel kind of zwitterionic hydrophilic interaction chromatography polymer particles, namely, poly(N,N-methylenebisacrylamide-co-methacrylic acid)@l-Cys (poly(MBAAm-co-MAA)@l-Cys), for the enrichment of glycopeptides was synthesized by a facile and efficient approach that combined distillation precipitation polymerization (DPP) and "thiol-ene" click reaction...
August 31, 2016: ACS Applied Materials & Interfaces
Weifeng Lin, Guanglong Ma, Jiang Wu, Shengfu Chen
Poly(sulfobetaine methacrylate) (pSBMA) and poly(carboxybetaine methacrylate) (pCBMA) are two well-known zwitterionic polymers known for their excellent antifouling properties. In this work, these two zwitterionic polymers were compared both in vitro and in vivo. Both of them exhibited excellent antifouling properties and low macrophage uptake although there were negligible differences in resistance to nonspecific protein adsorption of their hydrogels and cell internalization of their star polymers. However, it is found that the β- Cyclodextrin-CBMA (CD-CBMA) showed a circulation time one order of magnitude longer than CD-SBMA, which implied that small differences in vitro may lead to a dramatic difference in vivo...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
Yanfang Wang, Jian Shen, Jiang Yuan
Zwitterionic surface has been proven to be a good candidate for improving hemocompatible and antibiofouling properties. However, it can only passively repel the adsorption of microbes and is unable to kill the adherent or trapped microbes. The purpose of our study is to develop a facile method based on synergy "repel and kill" strategy and prepare dual antifouling and antibacterial surface. Herein, the poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) was first constructed via surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (ARGET-ATRP) method, followed by partial quaternization in order to form polycarboxybetaine and polysulfobetaine...
October 15, 2016: Journal of Colloid and Interface Science
Amir Sheikhi, Reghan J Hill
Dynamics of colloidal particles adhering to soft, deformable substrates, such as tissues, biofilms, and hydrogels play a key role in many biological and biomimetic processes. These processes, including, but not limited to colloid-based delivery, stitching, and sorting, involve microspheres exploring the vicinity of soft, sticky materials in which the colloidal dynamics are affected by the fluid environment (e.g., viscous coupling), inter-molecular interactions between the colloids and substrates (e.g., Derjaguin-Landau-Verwey-Overbeek (DLVO) theory), and the viscoelastic properties of contact region...
August 21, 2016: Soft Matter
Peiming Liu, Tao Huang, Pingsheng Liu, Shufeng Shi, Qiang Chen, Li Li, Jian Shen
Polyurethane (PU) is a biopolymer that has been commonly used for biomedical applications. However, the biofouling phenomenon on the hydrophobic PU surface is one of the crucial issues that embarrassing its applications. Here, we report a facile & efficient approach to improve the anti-biofouling ability of the PU substrates. Active residues were firstly generated on the PU surface by using the low temperature air-plasma treatment, promoting the immobilization of the atom transfer radical polymerization (ATRP) initiators on the surface...
October 15, 2016: Journal of Colloid and Interface Science
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