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zwitterionic polymer

Manman Zhu, Lingyi Zhang, Zhanying Chu, Shulei Wang, Kai Chen, Weibing Zhang, Fan Liu
An open tubular capillary liquid phase chromatographic column (1 m × 25 µm i.d.× 375 µm o.d.) was prepared by incorporating metal organic framework particles modified with vancomycin directly into zwitterionic polymer coating synthesized by the copolymerization of [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide and N,N'-methylenebisacrylamide. The incorporation of IRMOF-3 (isoreticular metal organic framework-3) particles improved selectivity of zwitterionic polymer coating with absolute column efficiency reaching 79900 plates for p-xylene...
July 1, 2018: Talanta
Changjian Song, Xiaohui Liu, Xiaodong Li, Ying-Chiao Wang, Li Wan, Xiaohua Sun, Wenjun Zhang, Junfeng Fang
Nonfullerene polymer solar cells (PSCs) have earned widespread and intense interest on account of their properties such as tunable energy levels, potential for low-cost production processes, reduced energy losses, and strong light absorption coefficients. Here, a water-/alcohol-soluble zwitterion perylene diimide zwitterion (PDI-z) consisted of sulfobetaine ion as a terminal substituent and PDI as a conjugated core was synthesized. PDI-z was employed as an electron-transport layer (ETL) for nonfullerene PSC devices, obtaining an optimal power conversion efficiency (PCE) above 11...
April 19, 2018: ACS Applied Materials & Interfaces
Santhosh Kalash Rajendrakumar, Ning-Chu Chang, Adityanarayan Mohapatra, Saji Uthaman, Byeong-Il Lee, Wei-Bor Tsai, In-Kyu Park
To prolong blood circulation and avoid the triggering of immune responses, nanoparticles in the bloodstream require conjugation with polyethylene glycol (PEG). However, PEGylation hinders the interaction between the nanoparticles and the tumor cells and therefore limits the applications of PEGylated nanoparticles for therapeutic drug delivery. To overcome this limitation, zwitterionic materials can be used to enhance the systemic blood circulation and tumor-specific delivery of hydrophobic agents such as IR-780 iodide dye for photothermal therapy...
April 13, 2018: International Journal of Molecular Sciences
Xiaoyu Jia, Dirong Gong, Junyi Zhao, Hongyun Ren, Jiani Wang, Xian Zhang
This paper describes the preparation of zwitterion-functionalized polymer microspheres (ZPMs) and their application to simultaneous enrichment of V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II) from environmental water samples. The ZPMs were prepared by emulsion copolymerization of ethyl methacrylate, 2-diethylaminoethyl methacrylate and triethylene glycol dimethyl acrylate followed by modification with 1,3-propanesultone. The components were analyzed by elemental analyses as well as Fourier transform infrared spectroscopy, and the structures were characterized by scanning electron microscopy and transmission electron microscopy...
March 19, 2018: Mikrochimica Acta
Quan Wang, Hang-Xing Li, Kun-Miao Wang, Xiao Wang, Zhe Xue, Lei Jia, Lin Du, Qi-Hua Zhao
Mixed azide and zwitterionic pyridiniums built Co(II) coordination polymer and its temperature-dependent magnetic properties are represented. We use Markov chain Monte Carlo (MCMC) method to fit the data, and find the following results: (1) there are strong correlations between the model parameters; (2) the data above the 28 K temperature are well fitted by the magnetism model.
March 26, 2018: Chemistry, An Asian Journal
Wenjin Guo, Xiang Li, Fuchang Xu, Yang Li, Junqi Sun
Transparent polymeric films have been successfully integrated with self-healing capabilities. However, these films can only heal damages in the scale of several to several tens of micrometers, thereby greatly limiting their practical applications. The present study reports the fabrication of transparent polymeric films capable of healing millimeter-scale cuts by incorporating hydrogen-bonding units into zwitterionic polymer films, which are cross-linked by electrostatic interactions. The intermolecular interactions in the resulting film are greatly reduced when the films absorb water as a result of the weak strength of the hydrogen bonds, thereby promoting the flowability of the film materials...
March 23, 2018: ACS Applied Materials & Interfaces
Musammir Khan, Janne T Koivisto, Terttu I Hukka, Mikko Hokka, Minna Kellomäki
Biopolymers are attractive candidates to fabricate biocompatible hydrogels, but the low water solubility of most of them at physiological pH, has hindered their applications. To prepare a water-soluble derivative of chitosan (WSC) biopolymer, it was grafted with a small anionic amino acid, L-glutamic acid, using a single step 1-Ethyl-3-[3-dimethylaminopropyl] carbodiimide coupling reaction. This resulted in a zwitterion-tethered structure onto the polymer backbone. The degree of substitution ranged between 13-16 ± 1...
March 15, 2018: ACS Applied Materials & Interfaces
Zihan An, Fengying Dai, Chenjie Wei, Yiping Zhao, Li Chen
Membrane surface design is significant for the development and application of synthetic polymer hemodialysis membranes. In this study, the influence of zwitterionic cysteine on poly(vinylidene fluoride) (PVDF) hollow fiber membrane was investigated. The polydopamine layer was formed through dopamine self-polymerization on PVDF membrane surface, and then cysteine was covalent grafted onto the layer to improve the anti-biofouling property and hemocompatibility. The elementary composition of membrane surfaces was characterized by X-ray photoelectron spectroscopy...
March 14, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Jiang Wu, Zecong Xiao, Anqi Chen, Huacheng He, Chaochao He, Xintao Shuai, Xiaokun Li, Shengfu Chen, Yanxian Zhang, Baiping Ren, Jie Zheng, Jian Xiao
Skin wound healing is a still long-history challenging problem and impeded by the foreign-body reaction including severe inflammation response, poor neovascularization, incomplete re-epithelialization and defective ECM remodeling. Development of biocompatible polymers, in combination with specific drugs or growth factors, has been considered as a promising strategy to treat skin wounds. Significant research efforts have been made to develop poly(ethylene glycol) PEG-based polymers for wound healing, however less efforts has been paid to zwitterionic materials, some of which have demonstrated their super low-fouling property in vitro and anti-inflammatory property in vivo...
March 10, 2018: Acta Biomaterialia
Qingyi Xie, Qianni Xie, Jiansen Pan, Chunfeng Ma, Guangzhao Zhang
Persistent protein resistance is critical for marine antibiofouling. We have prepared copolymer of 2-methylene-1,3-dioxepane (MDO), tertiary carboxybetaine ester (TCB) and 7-methacryloyloxy-4-methylcoumarin (MAMC) via radical ring-opening polymerization, where MDO, TCB and MAMC make the polymer degradable, protein resistible and photo-crosslinkable, respectively. Our study shows that the polymer can well adhere to the substrate with controlled degradation and water absorption rate in artificial seawater (ASW)...
March 12, 2018: ACS Applied Materials & Interfaces
S Mohanapriya, V Raj
A new class of bio composite materials for orthopedic applications were prepared by blending polyvinyl alcohol (PVA) with certain amino acids (AA) such as glycine, lysine and phenyl alanine followed by in-situ cross-linking with citric acid (CT). CT cross-linked PVA offers sufficient chemical, thermal, and morphological stability by establishing intermolecular interaction. These biocomposite films were characterized for mechanical and thermal behaviors as well as analyzed through SEM, TGA and AFM studies. Zwitterionic characteristics of AA create cell-adhesive hydrophilic domains that act as potential cell-adhesion sites and facilitate osteointegration...
May 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Umberto Capasso Palmiero, Matteo Maraldi, Nicolò Manfredini, Davide Moscatelli
Biodegradable polymer nanoparticles are an important class of materials used in several applications for their unique characteristics. In particular, the ones stabilized by zwitterionic materials are gaining increased interest in medicine as alternative to the more common ones based on poly(ethylene glycol) thanks to their superior stability and ability to avoid both the accelerated blood clearance and allergic reactions. In this work, a novel class of zwitterionic based NPs has been produced, and a method to independently control the nanoparticle size, degradation time, and polymer molecular weight has been developed and demonstrated...
March 15, 2018: Biomacromolecules
Saisai Lin, Yin Li, Lin Zhang, Shengfu Chen, Li'an Hou
Zwitterions of charge-balanced units have super-low fouling properties induced by ionic solvation, but their extensive applications on polymeric substrates are strictly constrained by current constructing strategies. In this work, a zwitterion-like, charge-balanced ultrathin layer with high antifouling capacity was covalently constructed on delicate aromatic polyamide (PA) reverse osmosis (RO) membranes via a mild and solvent-free grafting-to strategy. Two oppositely charged commercial short-chain carbonyl alkenes, 2-acrylamido-2-methyl propane sulfonic acid (AMPS) and methacryloxyethyltrimethyl ammonium chloride (DMSDMC), were directly mixed-grafted with amino groups on PA RO membrane surface via Michael addition...
March 7, 2018: Environmental Science & Technology
Wen Cui, Ruyu Wang, Xi Shu, Yu Fan, Yang Liu, Yongdong Jin, Chuanqin Xia, Chao Huang
The interaction between the uranyl cation, (UO2 )2+ , and organic species is of interest due to the potential applications of the resulting compounds with regard to nuclear waste disposal and nuclear fuel reprocessing. The hydrothermal reaction of various uranyl compounds with flexible zwitterionic 1,1'-[1,4-phenylenebis(methylene)]bis(pyridin-1-ium-4-carboxylate) dihydrochloride (Bpmb·2HCl) in deionized water containing drops of H2 SO4 resulted in the formation of a novel two-dimensional uranyl coordination polymer, namely poly[tetraoxido{μ2 -1,1'-[1,4-phenylenebis(methylene)]bis(pyridin-1-ium-4-carboxylate)}di-μ3 -sulfato-diuranium(VI)], [(UO2 )2 (SO4 )2 (C20 H16 N2 O4 )]n , (1)...
March 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
Chunyu Zhang, Xiaoyan Dong, Zheng Guo, Yan Sun
Enzymes are promising biocatalysts for the production or degradation of chemical compounds, but low stabilities of free enzymes restrict their industrial applications. Therefore, development of effective immobilization methods to maintain or increase enzyme activity and stability remains a challenge. In this work, a novel support made of zwitterionic polymer-grafted silica nanoparticles (p-SNPs) was fabricated and Candida rugosa lipase (CRL) was covalently attached onto the p-SNPs. The zwitterionic polymer was a product of the reaction between poly(maleic anhydride-alt-1-octadecene) and N,N-dimethylenediamine and contained a cetane side chain...
February 14, 2018: Journal of Colloid and Interface Science
Bowen Li, Zhefan Yuan, Peng Zhang, Andrew Sinclair, Priyesh Jain, Kan Wu, Caroline Tsao, Jingyi Xie, Hsiang-Chieh Hung, Xiaojie Lin, Tao Bai, Shaoyi Jiang
For biotherapeutics that require multiple administrations to fully cure diseases, the induction of undesirable immune response is one common cause for the failure of their treatment. Covalent binding of hydrophilic polymers to proteins is commonly employed to mitigate potential immune responses. However, while this technique is proved to partially reduce the antibodies (Abs) reactive to proteins, it may induce Abs toward their associated polymers and thus result in the loss of efficacy. Zwitterionic poly(carboxybetaine) (PCB) is recently shown to improve the immunologic properties of proteins without inducing any antipolymer Abs against itself...
February 19, 2018: Advanced Materials
Gökhan Kocak, Damla Ülker, Cansel Tuncer, Serife Betül Baker, Vural Bütün
A zwitterionic sulfobetaine-based diblock copolymer was successfully synthesized and used in the preparation and stabilization of Ag nanoparticles (AgNPs). For the related block copolymer, a precursor AB type diblock copolymer was synthesized via atom transfer radical polymerization by using a MPEG-based ATRP macroinitiator and 2-(N-dimethylamino)ethyl methacrylate (DMA) comonomer. Tertiary amine residues of PDMA blocks in poly(ethylene glycol) methyl ether-b-poly[2-(N-diethylamino)ethyl methacrylate] (MPEG-b-PDMA) precursor was then converted to polybetaine structures by reacting with 1,3-propanesultone to obtain poly(ethylene glycol) methyl ether-b-poly[3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonate] (MPEG-b-PβDMA) derivative...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Chong Zhang, Jingsong Yuan, Jianhua Lu, Yingqin Hou, Wei Xiong, Hua Lu
The development of high-performance nonfouling polymer surfaces for implantable medical devices and therapeutic nanomaterials is of great importance. Elaborating the relationship of polymer structural characteristics and the resulted surface properties can offer useful guidance toward ideal biointerfaces. In this work, we investigate the effects of the helical conformation and anchoring orientation of poly(α-amino acid)s (PαAAs) to produce advanced nonfouling surfaces. By using the neutral poly(γ-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)esteryl glutamates) (P(EG3Glu)s) as a model system, the adsorption kinetics are monitored by ex-situ variable angle spectroscopic ellipsometry and in-situ quartz crystal microbalance with dissipation...
February 3, 2018: Biomaterials
Wei Zhang, Zhe Yang, Yair Kaufman, Roy Bernstein
Zwitterion polymers have anti-fouling properties; therefore, grafting new zwitterions to surfaces, particularly as hydrogels, is one of the leading research directions for preventing fouling. Specifically, polyampholytes, polymers of random mixed charged subunits with a net-electric charge, offer a synthetically easy alternative for studying new zwitterions with a broad spectrum of charged moieties. Here, a novel polyampholyte hydrogel was grafted onto the surface of polyethersulfone membrane by copolymerizing a mixture of vinylsulfonic acid (VSA) and [2-(methacryloyloxy)ethyl]trimethylammonium chloride (METMAC) as the negatively and positively charged monomers, respectively, using various monomer ratios in the polymerization solution, and with N,N'-methylenebisacrylamide as the crosslinker...
January 31, 2018: Journal of Colloid and Interface Science
Pengfei Xu, Lei Wu, Liqiu Dong, Xin Xu
This work reports the chemoselective polymerization of polar divinyl monomers, including allyl methacrylate (AMA), vinyl methacrylate (VMA), and 4-vinylbenzyl methacrylate (VBMA), by using simple Lewis pairs comprised of homoleptic rare-earth (RE) aryloxide complexes RE(OAr)₃ (RE = Sc (1), Y (2), Sm (3), La (4), Ar = 2,6-tBu₂C₆H₃) and phosphines PR₃ (R = Ph, Cy, Et, Me). Catalytic activities of polymerizations relied heavily upon the cooperation of Lewis acid and Lewis base components. The produced polymers were soluble in common organic solvents and often had a narrow molecular weight distribution...
February 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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