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https://www.readbyqxmd.com/read/27892526/comprehensive-gene-expression-meta-analysis-and-integrated-bioinformatic-approaches-reveal-shared-signatures-between-thrombosis-and-myeloproliferative-disorders
#1
Prabhash Kumar Jha, Aatira Vijay, Anita Sahu, Mohammad Zahid Ashraf
Thrombosis is a leading cause of morbidity and mortality in patients with myeloproliferative disorders (MPDs), particularly polycythemia vera (PV) and essential thrombocythemia (ET). Despite the attempts to establish a link between them, the shared biological mechanisms are yet to be characterized. An integrated gene expression meta-analysis of five independent publicly available microarray data of the three diseases was conducted to identify shared gene expression signatures and overlapping biological processes...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822631/pancreatic-duct-involvement-in-well-differentiated-neuroendocrine-tumors-is-an-independent-poor-prognostic-factor
#2
Yoshihide Nanno, Ippei Matsumoto, Yoh Zen, Kyoko Otani, Jun Uemura, Hirochika Toyama, Sadaki Asari, Tadahiro Goto, Tetsuo Ajiki, Keiichi Okano, Yasuyuki Suzuki, Yoshifumi Takeyama, Takumi Fukumoto, Yonson Ku
BACKGROUND: The biological behavior of well-differentiated neuroendocrine tumors of the pancreas (PNETs) is difficult to predict. This study was designed to determine whether involvement of the main pancreatic duct (MPD) serves as a poor prognostic factor for PNETs. METHODS: The involvement of the MPD in PNETs was defined as ductal stenosis inside the tumor mass associated with distal MPDs more than twofold larger in diameter than the proximal ducts. We examined the correlation between MPD involvement and other clinicopathological parameters, including nodal metastasis and recurrence-free survival, in 101 patients treated consecutively at three referral centers in Japan...
November 7, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27739409/quantitative-assessment-of-provability-of-radiation-related-cancers-considering-unavoidable-existence-of-unadjusted-risk-factors
#3
H Ogino, Y Fujimichi, M Sasaki, N Hamada, T Iwasaki, K Yoshida, T Hattori
The attribution of stochastic effects to exposure to ionizing radiation has been qualitatively discussed by introducing two distinct concepts of provability and probability. This study aims to develop a method of quantitatively assessing the provability of radiation-related cancers. To this end, the 'minimum provable dose' (MPD) was developed and applied to actual cancer mortality in Japan. The background lifetime risk of cancer mortality was calculated for the esophagus, stomach, colon, liver, lungs, skin, breasts, ovaries, bladder, and bone marrow as well as the age-specific risk coefficients reproducing those given in the 2007 Recommendations of the International Commission on Radiological Protection (ICRP)...
October 14, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/27348228/dispatcher-stroke-recognition-using-a-stroke-screening-tool-a-systematic-review
#4
John Adam Oostema, Trevor Carle, Nadine Talia, Mathew Reeves
BACKGROUND: Emergency dispatchers represent the first point of contact for patients activating an acute stroke response. Accurate dispatcher stroke recognition is associated with faster emergency medical services response time; however, stroke is often unrecognized during initial emergency calls. Stroke screening tools such as the Cincinnati Prehospital Stroke Scale have been shown to improve on-scene stroke recognition and thus have been proposed as a means to improve dispatcher accuracy...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27330698/low-level-laser-therapy-versus-pharmacotherapy-in-improving-myofascial-pain-disorder-syndrome
#5
Hamid Reza Khalighi, Hamed Mortazavi, Seyed Masoud Mojahedi, Saranaz Azari-Marhabi, Faranak Moradi Abbasabadi
INTRODUCTION: Temporomandibular disorders (TMD) lead to masticatory muscle pain, jaw movement disability and limitation in mouth opening. Pain is the chief complaint in 90% of the TMD patients which leads to disability and severe socioeconomic costs. The purpose of this study was to evaluate the therapeutic effects of low level laser therapy (LLLT) compared to pharmacotherapy with NSAIDs (naproxen) in myofascial pain disorder syndrome (MPDS). METHODS: In this randomized controlled clinical trial, 40 MPDS patients were divided into two groups...
2016: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/27256173/predictive-ability-of-an-emergency-medical-dispatch-stroke-diagnostic-tool-in-identifying-hospital-confirmed-strokes
#6
Jeff J Clawson, Greg Scott, Isabel Gardett, Scott Youngquist, Peter Taillac, Conrad Fivaz, Christopher Olola
BACKGROUND: Early hospital notification of a possible stroke arriving via emergency medical services (EMS) can prepare stroke center personnel for timely treatment, especially timely administration of tissue plasminogen activator. Stroke center notification from the emergency dispatch center-before responders reach the scene-may promote even earlier and faster system activation, meaning that stroke center teams may be ready to receive patients as soon as the ambulance arrives. This study evaluates the use of a Medical Priority Dispatch System (MPDS; Priority Dispatch Corp...
August 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27174785/k-ras-v14i-induced-noonan-syndrome-predisposes-to-tumour-development-in-mice
#7
Isabel Hernández-Porras, Alberto J Schuhmacher, Raquel Garcia-Medina, Beatriz Jiménez, Marta Cañamero, Alba de Martino, Carmen Guerra
The Noonan syndrome (NS) is an autosomal dominant genetic disorder characterized by short stature, craniofacial dysmorphism, and congenital heart defects. A significant proportion of NS patients may also develop myeloproliferative disorders (MPDs), including juvenile myelomonocytic leukaemia (JMML). Surprisingly, scarce information is available in relation to other tumour types in these patients. We have previously developed and characterized a knock-in mouse model that carries one of the most frequent KRAS-NS-related mutations, the K-Ras(V14I) substitution, which recapitulates most of the alterations described in NS patients, including MPDs...
June 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27010144/early-blood-purification-therapy-of-severe-acute-pancreatitis-complicated-by-acute-lung-injury
#8
H Guo, D-W Suo, H-P Zhu, X-M Sun, J Chen
OBJECTIVE: Severe acute pancreatitis (SAP) can often be complicated by acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), leading to increased mortality. Early blood purification clears inflammatory cytokines and promotes immune function recovery. Here we evaluated the usefulness of this therapy in SAP complicated by ALI. PATIENTS AND METHODS: 32 patients received routine treatment (control group), whereas other 32 patients received routine treatment and early blood purification therapy (study group)...
March 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26874371/effect-of-the-osmolarity-change-in-multipurpose-solutions-induced-by-an-improper-contact-lens-case-cleaning-procedure
#9
José Pinto-Fraga, Antonio Abengózar-Vela, Alberto López-Miguel, Vicente Martín-Montañéz, Alberto López de la Rosa, María J González-García
PURPOSE: To determine whether variations in multipurpose disinfecting solution (MPDS) storage osmolarity from inappropriate contact lens (CL) case cleaning affect ocular surface integrity and wearer comfort. METHODS: There were twenty contact lens cases (study CLCs) in the study group. Ten were filled with ReNu Multiplus(®) and 10 with SoloCare Aqua™ (MPDS-1 and -2, respectively) and kept closed for 8h; the cases were then emptied and kept open for air-drying for 16h...
June 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/26758527/using-on-scene-ems-responders-assessment-and-electronic-patient-care-records-to-evaluate-the-suitability-of-emd-triaged-low-acuity-calls-for-secondary-nurse-triage-in-911-centers
#10
Greg Scott, Jeff Clawson, Mark C Fivaz, Jennie McQueen, Marie I Gardett, Bryon Schultz, Scott Youngquist, Christopher H O Olola
INTRODUCTION: Using the Medical Priority Dispatch System (MPDS) - a systematic 911 triage process - to identify a large subset of low-acuity patients for secondary nurse triage in the 911 center is a largely unstudied practice in North America. This study examines the ALPHA-level subset of low-acuity patients in the MPDS to determine the suitability of these patients for secondary triage by evaluating vital signs and necessity of lights-and-siren transport, as determined by attending Emergency Medical Services (EMS) ambulance crews...
February 2016: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/26617890/prevalence-of-the-frequency-of-jak2-v617f-mutation-in-different-myeloproliferative-disorders-in-egyptian-patients
#11
Gamal T Ebid, Mohamed Ghareeb, Omina Salaheldin, Mahmoud M Kamel
BACKGROUND AND OBJECTIVES: Detection of chromosomal abnormalities in myeloproliferative disorders is important for proper diagnosis of these disorders. This study has investigated the presence of JAK2 mutation (V617F) in Egyptian patients with myeloproliferative disorders referred to National Cancer institute, Cairo University. METHODS: The study involved 110 cases of Philadelphia negative Myeloproliferative diseases (MPDs), 70 cases with Polycythemia Vera (PV), 24 cases with Essential Thrombocytosis (ET) and 16 cases with Idiopathic Myelofibrosis (IMF) and 20 cases as a control group which represented as; (10 cases with secondary erythrocytosis, 1 case with reactive thrombocytosis, 4 cases as normal control and 5 as Philadelphia positive Chronic Myeloid Leukemia cases), they were collected from National Cancer Institute (NCI) over 3 years...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26572474/extended-release-and-enhanced-bioavailability-of-moxifloxacin-conjugated-with-hydrophilic-cellulose-ethers
#12
Nazia S Abbas, Muhammad Amin, Muhammad A Hussain, Kevin J Edgar, Muhammad N Tahir, Wolfgang Tremel
Macromolecular prodrugs (MPDs) of moxifloxacin were fabricated based on hydroxypropylcellulose (HPC) and hydroxyethylcellulose (HEC). UV/Vis spectrophotometry was employed to determine covalently loaded drug content (DC) of each conjugate. The degree of substitution (DS) of moxifloxacin attained ranged from 0.27 to 0.38 (HPC) and 0.19 to 0.26 (HEC) per anhydroglucose unit (AGU), respectively. Transmission electron microscopic analyses showed that HPC-moxifloxacin conjugates self-assembled into nanowires of ∼ 30 nm diameters while HEC-moxifloxacin conjugates self-assembled into nanoparticles of 150-350 nm...
January 20, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/26535552/realistic-simulation-of-regional-myocardial-perfusion-defects-for-cardiac-spect-studies
#13
George S K Fung, W Paul Segars, Taek-Soo Lee, Takahiro Higuchi, Alexander I Veress, Grant T Gullberg, Benjamin M W Tsui
The current 3D XCAT phantom allows users to manually define the regional myocardial perfusion defect (MPD) as a simple pie-shaped wedge region with reduced activity level in the myocardium of left ventricle. To more accurately and realistically model the MPD, we have developed a new regional MPD model for the 3D XCAT phantom for myocardial perfusion SPECT (MP-SPECT) studies based on the location and the severity of the stenosis in a computer generated coronary arterial tree. First, we generated a detailed coronary arterial tree by extending the large proximal branches segmented from patient CT images to cover the whole heart using an iterative rule-based algorithm...
October 2010: IEEE Nuclear Science Symposium Conference Record
https://www.readbyqxmd.com/read/26496720/early-results-of-low-level-laser-application-for-masticatory-muscle-pain-a-double-blind-randomized-clinical-study
#14
Erkan Sancakli, Bilge Gökçen-Röhlıg, Ali Balık, Değer Öngül, Selin Kıpırdı, Haluk Keskın
BACKGROUND: To evaluate the effect of Low Level Laser (LLL) application at the points of greatest pain in patients with chronic masticatory muscle pain. METHODS: A total number of 30 (21 women, 9 men, with a mean age of 39.2) were selected after the diagnosis of MPDS according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD). The patients were randomly divided into three groups; laser group I (n = 10); patients received the LLL at the point of greatest pain, laser group II (n = 10); patients received LLL at pre-established points in the effected muscles and placebo group (n = 10)...
2015: BMC Oral Health
https://www.readbyqxmd.com/read/26228180/influence-of-electric-current-pulses-on-the-solidification-of-cu-bi-sn-immiscible-alloys
#15
Jiang Hongxiang, He Jie, Zhao Jiuzhou
Continuous solidification experiments were carried out with Cu-Bi-Sn alloys under the effects of Electric Current Pulses (ECPs). A model describing the microstructure evolution was developed. The formation of the microstructure in the continuously solidified alloys was calculated. The calculations demonstrated that ECPs mainly affect the solidification process through changing the energy barrier for the nucleation of the minority phase droplets (MPDs). When the matrix liquid has a lower electric conductivity compared to the MPD, the ECPs lead to a decrease in the energy barrier for the nucleation of the MPDs which then promote the formation of a finely dispersed microstructure...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26186557/peripheral-blood-cells-from-children-with-rasopathies-show-enhanced-spontaneous-colonies-growth-in-vitro-and-hyperactive-ras-signaling
#16
G Gaipa, C Bugarin, P Cianci, J Sarno, P Bonaccorso, A Biondi, A Selicorni
Germline mutations in genes coding for molecules involved in the RAS/RAF/MEK/ERK pathway are the hallmarks of a newly classified family of autosomal dominant syndromes termed RASopathies. Myeloproliferative disorders (MPDs), in particular, juvenile myelomonocytic leukemia, can lead to potentially severe complications in children with Noonan syndrome (NS). We studied 27 children with NS or other RASopathies and 35 age-matched children as control subjects. Peripheral blood (PB) cells from these patients were studied for in vitro colony-forming units (CFUs) activity, as well as for intracellular phosphosignaling...
2015: Blood Cancer Journal
https://www.readbyqxmd.com/read/26177294/fasudil-a-clinically-safe-rock-inhibitor-decreases-disease-burden-in-a-cbl-cbl-b-deficiency-driven-murine-model-of-myeloproliferative-disorders
#17
Basem M William, Wei An, Dan Feng, Scott Nadeau, Bhopal C Mohapatra, Matthew A Storck, Vimla Band, Hamid Band
OBJECTIVES: Mutations in Cbl or Cbl-b gene occur in 10% of myeloproliferative disorder (MPD) patients and are associated with poor prognosis. Hematopoietic Cbl/Cbl-b double knockout (DKO) leads to a disease in mice phenotypically similar to human MPDs. The aim of this study was to evaluate the anti-MPD activity of a clinically safe drug, Fasudil, identified in an in vitro kinase inhibitor as an inhibitor of proliferation of DKO mouse hematopoietic stem/progenitor cells (HSPCs). METHODS: Fasudil exhibited relatively selective anti-proliferative activity against Cbl/Cbl-b DKO vs...
May 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/25951477/effect-of-daily-contact-lens-cleaning-on-ocular-adverse-events-during-extended-wear
#18
RANDOMIZED CONTROLLED TRIAL
Jerome Ozkan, Varsha M Rathi, Percy Lazon de la Jara, Thomas Naduvilath, Brien A Holden, Mark D P Willcox
PURPOSE: The purpose of the study was to assess what effect daily cleaning of contact lenses with a multipurpose disinfection solution (MPDS), during 30 nights extended wear, would have on contact lens-related adverse events. METHODS: This was a prospective, open-label, randomized, controlled, parallel-group, 3-month clinical study in which 193 participants were dispensed with lotrafilcon A silicone hydrogel lenses for a 30-day extended-wear schedule and with lenses replaced monthly...
February 2015: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/25918703/performance-of-three-multipurpose-disinfecting-solutions-with-a-silicone-hydrogel-contact-lens
#19
RANDOMIZED CONTROLLED TRIAL
Nery García-Porta, Laura Rico-del-Viejo, Helena Ferreira-Neves, Sofia C Peixoto-de-Matos, Antonio Queirós, José M González-Méijome
PURPOSE: To evaluate the clinical performance of a silicone hydrogel (Si-Hy) soft contact lens (CL) in combination with three different multipurpose disinfecting solutions (MPDSs). METHODS: This was a prospective, randomized, single-masked, crossover, and comparative study in which 31 habitual soft CL wearers were randomly assigned to one of the three MPDSs (Synergi, COMPLETE RevitaLens, and OPTI-FREE PureMoist) for 1 month with a 1-week wash-out period between each exposure...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25803811/screening-of-drugs-to-treat-8p11-myeloproliferative-syndrome-using-patient-derived-induced-pluripotent-stem-cells-with-fusion-gene-cep110-fgfr1
#20
Shohei Yamamoto, Makoto Otsu, Emiko Matsuzaka, Chieko Konishi, Haruna Takagi, Sachiyo Hanada, Shinji Mochizuki, Hiromitsu Nakauchi, Kohzoh Imai, Kohichiro Tsuji, Yasuhiro Ebihara
Induced pluripotent stem (iPS) cells provide powerful tools for studying disease mechanisms and developing therapies for diseases. The 8p11 myeloproliferative syndrome (EMS) is an aggressive chronic myeloproliferative disorder (MPD) that is caused by constitutive activation of fibroblast growth factor receptor 1. EMS is rare and, consequently, effective treatment for this disease has not been established. Here, iPS cells were generated from an EMS patient (EMS-iPS cells) to assist the development of effective therapies for EMS...
2015: PloS One
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