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Cost utility analysis

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https://www.readbyqxmd.com/read/29694287/one-year-outcomes-of-an-integrated-multiple-sclerosis-disease-management-program
#1
Marti Groeneweg, Sara H Forrester, Beth Arnold, Lorella Palazzo, Weiwei Zhu, Paul Yoon, Tim Scearce
BACKGROUND: Multiple sclerosis (MS) is associated with high total health care cost, the majority of which is attributable to medications. Patients with MS are less likely to experience relapses, emergency department (ED) visits, and hospitalizations when they are adherent to disease-modifying treatments. Disease management programs are hypothesized to improve medication adherence thereby improving clinical and economic outcomes. OBJECTIVE: To evaluate the clinical and economic effects of a specialty pharmacy and chronic disease management program for patients with MS from a health plan perspective...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29691782/cost-effectiveness-of-aspirin-adherence-for-secondary-prevention-of-cardiovascular-events
#2
Laurence M Djatche, Stefan Varga, Robert D Lieberthal
BACKGROUND: Suboptimal adherence to aspirin therapy for secondary prevention of cardiovascular (CV) events is an important public health problem. Prior studies have demonstrated non-adherent patients are at higher risk of experiencing CV events. OBJECTIVES: This study aimed to estimate the clinical and economic outcomes of aspirin non-adherence in patients with a prior primary CV event. METHODS: We developed a Markov model to estimate the cost-effectiveness of aspirin adherence from a generic US managed care payer perspective over a 5-year time horizon...
April 24, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29689263/analysis-of-glycogen-metabolic-pathway-utilization-by-dendritic-cells-and-t-cells-using-custom-phenotype-metabolic-assays
#3
Phyu Thwe, Eyal Amiel
In the field of immunology, there is an increasing interest in cellular energy metabolism and its outcome on immune cell effector function. Activation of immune cells leads to rapid metabolic changes that are central to cellular biology in order to support the effector responses. Therefore, the need for user-friendly and dependable assay technologies to address metabolic regulation and nutrient utilization in immune cells is an important need in this field. Redox-dye reduction-based Phenotype MicroArray (PM) assays, which measure NADH reduction as a readout, developed by Biolog Inc...
April 21, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29687743/clinical-outcomes-of-treatment-with-filgrastim-versus-a-filgrastim-biosimilar-and-febrile-neutropenia-associated-costs-among-patients-with-nonmyeloid-cancer-undergoing-chemotherapy
#4
Lee S Schwartzberg, Lincy S Lal, Sanjeev Balu, Kim Campbell, Lee Brekke, Andrew DeLeon, Caitlin Elliott, Stephanie Korrer
BACKGROUND: Granulocyte colony-stimulating factors such as filgrastim are used to decrease the incidence of febrile neutropenia (FN) among patients with nonmyeloid cancers undergoing chemotherapy treatment. Although the biosimilar filgrastim-sndz has been approved in the United States since 2015, limited real-world comparisons of filgrastim-sndz versus reference filgrastim (filgrastim-ref) have been conducted. OBJECTIVE: To compare FN incidence and assess overall FN-related health care resource utilization and medical costs among U...
April 24, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29687326/are-iso-osmolar-as-compared-to-low-osmolar-contrast-media-cost-effective-in-patients-undergoing-cardiac-catheterization-an-economic-analysis
#5
Swapnil Hiremath, Ayub Akbari, George A Wells, Benjamin J W Chow
PURPOSE: Contrast-induced acute kidney injury is a prominent complication following cardiac catheterization, though the risk has progressively decreased in recent times with appropriate risk stratification and use of safer contrast agents. Despite data supporting further lowering of risk with the iso-osmolar agent, iodixanol, uptake has lagged, perhaps due to increased upfront cost of this agent. We undertook an economic analysis to estimate the cost-effectiveness of a strategy utilizing iodixanol compared to using a low-osmolar contrast agent...
April 23, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29687268/cost-effectiveness-of-enhancing-a-quit-and-win-smoking-cessation-program-for-college-students
#6
Jonah Popp, John A Nyman, Xianghua Luo, Jill Bengtson, Katherine Lust, Lawrence An, Jasjit S Ahluwalia, Janet L Thomas
OBJECTIVES: We conducted a cost-effectiveness analysis and model-based cost-utility and cost-benefit analysis of increased dosage (3 vs. 1 consecutive contests) and enhanced content (supplemental smoking-cessation counseling) of the Quit-and-Win contest using data from a randomized control trial enrolling college students in the US. METHODS: For the cost-utility and cost-benefit analyses, we used a microsimulation model of the life course of current and former smokers to translate the distribution of the duration of continuous abstinence among each treatment arm's participants observed at the end of the trial (N = 1217) into expected quality-adjusted life-years (QALYs) and costs and an incremental net monetary benefit (INMB)...
April 23, 2018: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/29687022/influenza-like-illness-as-a-trigger-for-ischemic-stroke
#7
Amelia K Boehme, Jorge Luna, Erin R Kulick, Hooman Kamel, Mitchell S V Elkind
Objective: We hypothesized that ILI is associated with risk of incident stroke, and that the risk would be highest closest in time to the event. Methods: This case-crossover analysis utilized data obtained from the California State Inpatient Database of the Healthcare Cost and Utilization Project (HCUP). The outcome of interest was ischemic stroke. Exposure was defined as a visit to the emergency department or hospitalization for influenza-like illness (ILI) 365, 180, 90, 30, or 15 days before stroke (risk period) or similar time intervals exactly 1 or 2 years before stroke (control period)...
April 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29686900/are-unnecessary-serial-radiographs-being-ordered-in-children-with-distal-radius-buckle-fractures
#8
Shi-Neng James Ling, Aidan J Cleary
Background. Torus or buckle distal radius fractures are common injuries in the pediatric population. By definition, they are stable and can be treated conservatively with a wrist splint or soft crepe bandage. Objective. The objective of this study was to evaluate the utility of serial radiographs in the clinical outcome of children with stable distal radius buckle fractures. Materials and Methods. A one-month retrospective analysis was undertaken at two major hospitals in Queensland-Logan and Redlands Hospital...
2018: Radiology Research and Practice
https://www.readbyqxmd.com/read/29685498/using-state-space-models-to-predict-the-abundance-of-juvenile-and-adult-sea-lice-on-atlantic-salmon
#9
Adel Elghafghuf, Raphael Vanderstichel, Sophie St-Hilaire, Henrik Stryhn
Sea lice are marine parasites affecting salmon farms, and are considered one of the most costly pests of the salmon aquaculture industry. Infestations of sea lice on farms significantly increase opportunities for the parasite to spread in the surrounding ecosystem, making control of this pest a challenging issue for salmon producers. The complexity of controlling sea lice on salmon farms requires frequent monitoring of the abundance of different sea lice stages over time. Industry-based data sets of counts of lice are amenable to multivariate time-series data analyses...
April 11, 2018: Epidemics
https://www.readbyqxmd.com/read/29684386/valuing-innovative-endoscopic-techniques-per-oral-endoscopic-myotomy-for-the-management-of-achalasia
#10
Eric D Shah, Andrew C Chang, Ryan Law
BACKGROUND AND AIMS: Unclear reimbursement for new and innovative endoscopic procedures can limit adoption in clinical practice despite effectiveness in clinical trials. The aim of this study was to determine maximum cost-effective reimbursement for per-oral endoscopic myotomy (POEM) in treating achalasia. METHODS: We constructed a decision analytic model assessing POEM versus laparoscopic Heller myotomy with Dor fundoplication (LHM) in managing achalasia from a payer perspective over a 1-year time horizon...
April 20, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29684121/incidence-and-prevalence-of-diabetes-and-cost-of-illness-analysis-of-polycystic-ovary-syndrome-a-bayesian-modelling-study
#11
Tao Ding, Paul J Hardiman, Irene Petersen, Gianluca Baio
STUDY QUESTION: What is the incidence/prevalence of type 2 diabetes in women with polycystic ovary syndrome (PCOS) and the economic burden associated with PCOS in the UK? SUMMARY ANSWER: The incidence and prevalence of type 2 diabetes in women with PCOS are 3-33 per 1000 person years and 26.5%, respectively, with an associated annual healthcare burden of at least £237 million in the UK. WHAT IS KNOWN ALREADY: Although observational studies have been designed to assess the incidence of diabetes in women with PCOS, these have been open to criticism because of short periods of follow-up, small sample sizes or invalidated diagnosis of PCOS...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29683880/economic-analysis-of-neoadjuvant-chemotherapy-versus-primary-debulking-surgery-for-advanced-epithelial-ovarian-cancer-using-an-aggressive-surgical-paradigm
#12
Ashley L Cole, Emma L Barber, Anagha Gogate, Arthur-Quan Tran, Stephanie B Wheeler
OBJECTIVES: Neoadjuvant chemotherapy (NACT) versus primary debulking surgery (PDS) for advanced epithelial ovarian cancer (AEOC) remains controversial in the United States. Generalizability of existing trial results has been criticized because of less aggressive debulking procedures than commonly used in the United States. As a result, economic evaluations using input data from these trials may not accurately reflect costs and outcomes associated with more aggressive primary surgery. Using data from an ongoing trial performing aggressive debulking, we investigated the cost-effectiveness and cost-utility of NACT versus PDS for AEOC...
April 21, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29683095/azilsartan-and-chlorthalidone-new-powerful-fixed-dose-antihypertensive-combination
#13
Vasiliki Katsi, Eleni Athanasiadi, Costas Tsioufis, Dimitris Tousoulis
Arterial hypertension is a disease that still affects a major part of the population worldwide, and leads to fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. From the CDC statistical analysis, as regarding to United States, 1 of every 3 adults has high blood pressure, and οnly about half (54%) of them have it under control. Furthermore, all that leads to a nation cost about $46 billion each year. Efforts to find new ways to regulate arterial hypertension are therefore imperative...
April 20, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29682769/biophysical-measurement-of-red-blood-cells-by-lab-on-pcb-chip
#14
Ying Zhao, Wengeng Zhang
Microfluidic impedance pulse sensor has emerged as easy-handling and low-cost platform in the electrical analysis of biological cells. In the conventional method, impedance sensor demanded expensively patterning metal electrodes on the substrate, which are directly in touch with electrolytes in order to measure the microfluidic channel impedance change. In this letter, a cost-effective microfluidic impedance sensor building upon a dielectric film coated printed circuit board is introduced. Impedance electrodes are protected by a dielectric film layer from electrochemical erosion between electrodes and electrolyte...
April 22, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29682599/microfluidic-flow-cytometry-the-role-of-microfabrication-methodologies-performance-and-functional-specification
#15
Anil B Shrirao, Zachary Fritz, Eric M Novik, Gabriel M Yarmush, Rene S Schloss, Jeffrey D Zahn, Martin L Yarmush
Flow cytometry is an invaluable tool utilized in modern biomedical research and clinical applications requiring high throughput, high resolution particle analysis for cytometric characterization and/or sorting of cells and particles as well as for analyzing results from immunocytometric assays. In recent years, research has focused on developing microfluidic flow cytometers with the motivation of creating smaller, less expensive, simpler, and more autonomous alternatives to conventional flow cytometers. These devices could ideally be highly portable, easy to operate without extensive user training, and utilized for research purposes and/or point-of-care diagnostics especially in limited resource facilities or locations requiring on-site analyses...
March 2018: Technology
https://www.readbyqxmd.com/read/29681276/diffusion-based-humidity-control-membrane-for-microfluidic-based-gas-detectors
#16
Mohammad Paknahad, Jannat Singh Bachhal, Mina Hoorfar
This paper presents a cost-effective and reliable diffusion-based humidity removal membrane for microfluidic-based gas analyzers. The developed humidity control device reduces the relative humidity of a gas chamber and also stabilizes the humidity using inexpensive inorganic salts. A 3D-printed microfluidic gas sensor is used to test four different volatile organic compounds (VOCs) including three alcohols and one ketone in different relative humidity levels ranging from 15% to 80%. To study the effects of humidity on different features of the transient response of the sensor, two different feature extraction methods are used...
August 27, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29681200/cost-analysis-of-plasma-derived-factor-viii-von-willebrand-factor-vs-recombinant-factor-viii-for-treatment-of-previously-untreated-patients-with-severe-hemophilia-a-in-the-united-states
#17
Ellis J Neufeld, Robert F Sidonio, Ken O'Day, M Chris Runken, Kellie Meyer, Jeffrey Spears
BACKGROUND: Inhibitor development to factor VIII (FVIII) hemophilia therapy results in increased complications and substantial economic costs. The SIPPET study, the first randomized controlled trial to compare the immunogenicity of plasma-derived FVIII (pdFVIII)/von Willebrand factor (VWF) and recombinant-DNA-derived FVIII (rFVIII), demonstrated higher inhibitor rates in previously untreated patients (PUPs) treated with rFVIII than in PUPs treated with pdFVIII/VWF. OBJECTIVE: To quantify the economic impact of treating PUPs with pdFVIII/VWF versus rFVIII...
April 21, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29680106/cost-of-tuberculosis-diagnosis-and-treatment-in-patients-with-hiv-a-systematic-literature-review
#18
REVIEW
Noemia Teixeira de Siqueira-Filha, Rosa Legood, Aracele Cavalcanti, Andreia Costa Santos
OBJECTIVES: To summarize the costs of tuberculosis (TB) diagnosis and treatment in human immunodeficiency virus (HIV)-infected patients and to assess the methodological quality of these studies. METHODS: We included cost, cost-effectiveness, and cost-utility studies that reported primary costing data, conducted worldwide and published between 1990 and August 2016. We retrieved articles in PubMed, Embase, EconLit, CINAHL plus, and LILACS databases. The quality assessment was performed using two guidelines-the Consolidated Health Economic Evaluation Reporting Standards and the Tool to Estimate Patient's Costs...
April 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29680105/utility-based-instruments-for-people-with-dementia-a-systematic-review-and-meta-regression-analysis
#19
REVIEW
Li Li, Kim-Huong Nguyen, Tracy Comans, Paul Scuffham
BACKGROUND: Several utility-based instruments have been applied in cost-utility analysis to assess health state values for people with dementia. Nevertheless, concerns and uncertainty regarding their performance for people with dementia have been raised. OBJECTIVES: To assess the performance of available utility-based instruments for people with dementia by comparing their psychometric properties and to explore factors that cause variations in the reported health state values generated from those instruments by conducting meta-regression analyses...
April 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29680096/a-comparison-of-coverage-restrictions-for-biopharmaceuticals-and-medical-procedures
#20
James Chambers, Elle Pope, Kathy Bungay, Joshua Cohen, Michael Ciarametaro, Robert Dubois, Peter J Neumann
BACKGROUND: Differences in payer evaluation and coverage of pharmaceuticals and medical procedures suggest that coverage may differ for medications and procedures independent of their clinical benefit. We hypothesized that coverage for medications is more restricted than corresponding coverage for nonmedication interventions. METHODS: We included top-selling medications and highly utilized procedures. For each intervention-indication pair, we classified value in terms of cost-effectiveness (incremental cost per quality-adjusted life-year), as reported by the Tufts Medical Center Cost-Effectiveness Analysis Registry...
April 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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