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Guillain_Barre

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https://www.readbyqxmd.com/read/28425041/familial-amyloid-cardiomyopathy-masquerading-as-chronic-guillain-barre-syndrome-things-are-not-always-what-they-seem
#1
Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng
Familial amyloid cardiomyopathy is a challenging condition that mimics many other diseases, particularly in patients with pronounced neurological presentations and unexplained or equivocal cardiac abnormalities. In this case, a 57-year-old man was admitted for outpatient cardiological evaluation of progressive right heart failure and limb paraesthesias. The patient presented with hypertension, chronic Guillain-Barre syndrome, and sick sinus syndrome. Transthoracic echocardiograms showed a thickened ventricular wall and enlarged atrium...
April 19, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28423140/arboviruses-emerging-in-brazil-challenges-for-clinic-and-implications-for-public-health
#2
Maria Rita Donalisio, André Ricardo Ribas Freitas, Andrea Paula Bruno Von Zuben
Arboviruses have been emerging in different parts of the world due to genetic changes in the virus, alteration of the host and vector population dynamics, or because of anthropogenic environmental factors. These viruses' capacity for adaptation is notable, as well as the likelihood of their emergence and establishment in new geographic areas. In Brazilian epidemiologic scenario, the most common arboviruses are DENV, CHIKV, and ZIKV, although others may spread in the country. Little is yet known of the impact of viral co-circulation, which would theoretically result in more intense viremia or other immunological alterations that could trigger autoimmune diseases, such as Guillain-Barré syndrome...
April 10, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28422939/predictive-factors-for-achieving-independent-walking-in-children-with-guillain-barre-syndrome
#3
Mohammad Barzegar, Vahideh Toopchizadeh, Mohammad Hk Maher, Paria Sadeghi, Fatemeh Jahanjoo, Alireza Pishgahi
BACKGROUND: To determine the predictors of achieving independent walking at 2 and 6 months after onset of weakness in children with Guillain-Barre Syndrome (GBS). METHODS: Children with GBS admitted to Tabriz Children's Hospital were studied prospectively. All patients had frequent clinical evaluations until achieving independent walking. Unaided walking at 2 and 6 months, and factors influencing these outcomes were determined using both univariate and multiple analysis...
April 19, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28413724/are-anti-ganglioside-antibodies-associated-with-proventricular-dilatation-disease-in-birds
#4
Jeann Leal de Araujo, Ian Tizard, Jianhua Guo, J Jill Heatley, Aline Rodrigues Hoffmann, Raquel R Rech
The identification of Parrot bornaviruses (PaBV) in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease, since not all infected birds develop clinical signs. Although the most accepted theory indicates that PaBV directly triggers an inflammatory response in this disease, another hypothesis suggests the disease is triggered by autoantibodies targeting neuronal gangliosides, and PDD might therefore resemble Guillain-Barré Syndrome (GBS) in its pathogenesis...
2017: PeerJ
https://www.readbyqxmd.com/read/28406555/international-guillain-barr%C3%A3-syndrome-outcome-study-igos-protocol-of-a-prospective-observational-cohort-study-on-clinical-and-biological-predictors-of-disease-course-and-outcome-in-guillain-barr%C3%A3-syndrome
#5
Bart C Jacobs, Bianca van den Berg, Christine Verboon, Govindsinh Chavada, David R Cornblath, Kenneth C Gorson, Thomas Harbo, Hans-Peter Hartung, Richard A C Hughes, Susumu Kusunoki, Pieter A van Doorn, Hugh J Willison
Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multi-centre cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here...
April 12, 2017: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/28403328/zika-puzzle-in-brazil-peculiar-conditions-of-viral-introduction-and-dissemination-a-review
#6
Cristina Possas, Patricia Brasil, Mauro Ca Marzochi, Amilcar Tanuri, Reinaldo M Martins, Ernesto Ta Marques, Myrna C Bonaldo, Antonio Gp Ferreira, Ricardo Lourenço-de-Oliveira, Rita Maria R Nogueira, Patricia C Sequeira, Keyla Bf Marzochi, Akira Homma
This article discusses the peculiar conditions that favoured the unexpected introduction of Zika virus into the poorest northeastern region of Brazil in 2015, its speed of transmission to other Brazilian states, other Latin American countries and other regions, and the severity of related neurological disorders in newborns and adults. Contrasting with evidence that Zika had so far caused only mild cases in humans in the last six decades, the epidemiological scenario of this outbreak in Brazil indicates dramatic health effects: in 2015, an increase of 20-fold in notified cases of microcephaly and/or central nervous system (CNS) alterations suggestive of Zika congenital infection, followed by an exponential increase in 2016, with 2366 cumulative cases confirmed in the country by the end of December 2016...
April 6, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28403109/low-serum-levels-of-uric-acid-and-albumin-in-patients-with-guillain-barre-syndrome
#7
Zhongqian Su, Zhibo Chen, Yian Xiang, Bingjie Wang, Yuanyuan Huang, Dehao Yang, Xiang Li, Yiyun Weng, XianFeng Lin, Guoqian Chen, Wenyue Liu, Chenchen Zhao, Qingqing Wang, Shanshan Li, Ying Chen, Ying Chen, Weiwei Quan, Qiuling Tong, Shengjie Wu, Shihao Huang, Peina Mei, Zhengzheng Li, Jia Li, Shengtao Hou, Xu Zhang
Free radical toxicity due to poorly maintained cellular redox levels is crucial events that have been associated with the pathogenesis of Guillain-Barre syndrome (GBS) patients. Uric acid (UA) and albumin correlate with oxidative stress in some degree. We aimed to evaluate the relationship between GBS and serum levels of UA and albumin in the present study.The serum levels of UA and albumin were determined in 203 individuals including 88 patients with GBS and 153 healthy controls (HC).We found that serum levels of UA and albumin in patients with GBS were significantly lower than those in HC group...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28397799/an-mrna-based-vaccine-strategy-against-zika
#8
Gary Wong, George F Gao
Infections with Zika virus are strongly associated with complications such as congenital microcephaly and can trigger Guillain-Barré syndrome in humans, highlighting the urgent need for a safe, efficacious vaccine as a preventative countermeasure. In a recent paper published in Cell, Richner et al. generated a lipid nanoparticle encapsulated modified mRNA vaccine encoding the prM and E genes from Zika virus, which showed protection and sterilizing immunity in immunocompetent mice.
April 11, 2017: Cell Research
https://www.readbyqxmd.com/read/28397393/early-discrimination-of-sensorimotor-guillain-barr%C3%A3-syndrome-into-demyelinating-or-axonal-subtype-by-automated-nerve-excitability-testing
#9
So Young Pyun, Mi-Ri Kang, Joo Young Lee, Kim Jong Kuk, Seong-Il Oh, Jong Seok Bae
In the early stage of disease, differentiating acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor sensory axonal neuropathy (AMSAN) using only a conventional nerve conduction studies (NCS) may be difficult. We evaluated the differences in the motor axonal excitability properties of 16 cases of sensorimotor Guillain-Barré syndrome by nerve excitability testing (NET). The antiganglioside antibody assay and follow-up NCS resulted in 12 patients diagnosed as AIDP and 4 patients as AMSAN. Clinical and excitability parameters in each group were compared with those in 30 normal controls...
April 11, 2017: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/28397145/a-case-of-atypical-ophthalmoplegia-after-chikungunya-fever
#10
Paromita Dutta, Ankita Sharma
PURPOSE: This study aims to report an unusual case of bilateral diffuse ophthalmoplegia with levator sparing, in a patient after an episode of Chikungunya fever. METHODS: Case report of a five-year-old girl with inability to move both eyes along with decreased near vision. RESULT AND CONCLUSION: Bilateral external ophthalmoplegia has been described as a part of the spectrum of ocular manifestations of this arbovirus-associated fever. This is the first report of its kind in a pediatric patient...
April 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28393598/-zika-virus-infection-in-pregnancy
#11
Gabriella Varjasi, Róbert Póka
The Zika virus is a flavivirus spread by mosquitoes. Its primary vectors are the Aedes aegypti and the Aedes albopictus. Before 2007 it sporadically caused benign morbidity. Since 2015, it started spreading "explosively" in America, especially in Brazil. In August 2016 they reported cases from New York and Poland, too. Most of the infections don't produce any symptoms, but can cause grave complications. The most important lesion is microcephalia that forms in fetuses. Microcephalia's most serious consequence is mental retardation, which puts great burden on both the family and the society...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28375542/emergence-of-zika-virus-epidemic-and-the-national-response-in-jamaica
#12
K R Webster-Kerr, Cdc Christie, A Grant, D Chin, H Burrowes, K Clarke, I Wellington, K Shaw, W De La Haye
Background: Jamaica, along with the Americas, experienced major epidemics of arboviral diseases transmitted by the Aedes aegypti mosquito in recent years. These include dengue fever in 2012, Chikungunya fever in 2014 and Zika virus infection (ZIKV) in 2016. We present the emergence of the ZIKV epidemic in Jamaica and outline the national response. Methods: The Ministry of Health's preparedness included: heightened surveillance, clinical management guidance, vector control and management, laboratory capacity strengthening, training and staffing, risk communication and public education, social mobilization, inter-sectoral collaboration, resource mobilization and international cooperation...
September 26, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/28375541/unravelling-the-paediatric-and-perinatal-zika-virus-epidemic-through-population-based-research
#13
Cdc Christie, C Giaquinto
Zika virus epidemic now involves 72 countries, worldwide. Transmission is multimodal through mosquito bites and blood and body fluids. Zika virus causes Guillain Barre Syndrome syndrome and pregnancy complications including perinatal microcephaly. Diagnosis is complicated by subclinical infection in 80%, co-circulation with dengue and chikungunya fevers with similar presentations and cross-reactivity in serological tests. There is no cure, or preventive vaccine. Large population-based studies will help to elucidate ZIKV epidemiology, vertical transmission, risks to the fetus of maternal ZIKV infection and natural history of congenital and non-congenital ZIKV infection as provided by the activities in the "ZIKAction" research consortium in Latin America, Europe and the Caribbean, which was recently funded by the European Commission...
September 19, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/28370966/zika-infection-and-the-development-of-neurological-defects
#14
REVIEW
Fabiele Baldino Russo, Patricia Jungmann, Patricia Cristina Baleeiro Beltrão-Braga
Starting with the outbreak in Brazil, Zika virus (ZIKV) infection has been correlated with severe syndromes such as Congenital Zika Syndrome (CZS) and Guillain- Barré Syndrome (GBS). Here we review the status of Zika virus pathogenesis in the central nervous system (CNS). One of the main concerns about ZIKV exposure during pregnancy is abnormal brain development, which results in microcephaly in newborns. Recent advances in in vitro research show that ZIKV can infect and obliterate cells from the CNS, such as progenitors, neurons, and glial cells...
March 31, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28368871/rehabilitation-of-guillain-barr%C3%A3-syndrome-patients-an-observational-study
#15
Primož Novak, Sonja Šmid, Gaj Vidmar
Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating polyradiculopathy resulting in severe impairments of many body structures and functions with consequent limitations of activities and participation. The aim of our study was to evaluate rehabilitation outcome in these patients. Forty-five (20 women, 25 men) with GBS patients who had completed primary comprehensive rehabilitation were included in the study. Medical Research Council Scale for Muscle Strength was used for assessment of lower-limb function...
March 31, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28367386/a-case-of-miller-fisher-syndrome-and-literature-review
#16
Sumera Bukhari, Javier Taboada
Miller Fisher syndrome (MFS)  was first recognized by James Collier in 1932 as a clinical triad of ataxia, areflexia, and ophthalmoplegia. Later, it was described in 1956 by Charles Miller Fisher as a possible variant of Guillain-Barré syndrome (GBS). Here, we write a case of a patient with atypical presentation of this clinical triad as the patient presented with double vision initially due to unilateral ocular involvement that progressed to bilateral ophthalmoplegia. He developed weakness of the lower extremities and areflexia subsequently...
February 22, 2017: Curēus
https://www.readbyqxmd.com/read/28360817/carcinoid-tumor-associated-paraneoplastic-polyneuropathy-that-mimics-guillain-barre-syndrome
#17
Çetin Kürşad Akpinar, Hacer Erdem Tilki, Hüseyin Şahin, Taner Özbenli
No abstract text is available yet for this article.
December 2016: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28358795/zika-virus-transmission-region-of-the-americas-may-15-2015-december-15-2016
#18
Juniorcaius Ikejezie, Craig N Shapiro, Jisoo Kim, Monica Chiu, Maria Almiron, Ciro Ugarte, Marcos A Espinal, Sylvain Aldighieri
Zika virus, a mosquito-borne flavivirus that can cause rash with fever, emerged in the Region of the Americas on Easter Island, Chile, in 2014 and in northeast Brazil in 2015 (1). In response, in May 2015, the Pan American Health Organization (PAHO), which serves as the Regional Office of the Americas for the World Health Organization (WHO), issued recommendations to enhance surveillance for Zika virus. Subsequently, Brazilian investigators reported Guillain-Barré syndrome (GBS), which had been previously recognized among some patients with Zika virus disease, and identified an association between Zika virus infection during pregnancy and congenital microcephaly (2)...
March 31, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28357183/tuberculosis-and-guillain-barre-syndrome-a-chance-association
#19
Srikant Mohta, Manish Soneja, Surabhi Vyas, Wasim Khot
An 18-year-old boy presented with acute-onset quadriparesis that had developed 4 weeks prior. He had an intermittent fever and significant weight loss during this period. After extensive investigations, the patient was diagnosed with an acute motor and sensory axonal neuropathy (AMSAN) variant of Guillain-Barre syndrome (GBS) and disseminated tuberculosis with mediastinal lymphadenopathy, pericarditis, and pleural effusion. Plasmapheresis was performed and first-line anti-tubercular therapy was administered...
February 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28349242/host-virus-interaction-of-zika-virus-in-modulating-disease-pathogenesis
#20
REVIEW
Nanda Kishore Routhu, Siddappa N Byrareddy
The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. It primarily spreads either through infected Aedes aegypti or Aedes albopictus mosquitos leading to severe neurological disorders such as microcephaly and Guillain-Barré syndrome in susceptible individuals. The mode of ZIKV entry into specific cell types such as: epidermal keratinocytes, fibroblasts, immature dendritic cells (iDCs), and stem-cell-derived human neural progenitors has been determined through its major surface envelope glycoprotein...
March 27, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
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