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Caffeine receptor

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https://www.readbyqxmd.com/read/29431797/sustained-consumption-of-cocoa-based-dark-chocolate-enhances-seizure-like-events-in-the-mouse-hippocampus
#1
Ana Cicvaric, Tanja Bulat, Daniel Bormann, Jiaye Yang, Bastian Auer, Ivan Milenkovic, Maureen Cabatic, Radoslav Milicevic, Francisco J Monje
While the consumption of caffeine and cocoa has been associated with a variety of health benefits to humans, some authors have proposed that excessive caffeine intake may increase the frequency of epileptic seizures in humans and reduce the efficiency of antiepileptic drugs. Little is known, however, about the proconvulsant potential of the sustained, excessive intake of cocoa on hippocampal neural circuits. Using the mouse as an experimental model, we examined the effects of the chronic consumption of food enriched in cocoa-based dark chocolate on motor and mood-related behaviours as well as on the excitability properties of hippocampal neurons...
February 12, 2018: Food & Function
https://www.readbyqxmd.com/read/29427818/mutation-linked-excessively-tight-interaction-between-the-calmodulin-binding-domain-and-c-terminal-domain-of-the-cardiac-ryanodine-receptor-as-a-novel-cause-of-catecholaminergic-polymorphic-ventricular-tachycardia
#2
Shigehiko Nishimura, Takeshi Yamamoto, Yoshihide Nakamura, Michiaki Kohno, Yoriomi Hamada, Yoko Sufu, Go Fukui, Takuma Nanno, Hironori Ishiguchi, Takayoshi Kato, Xiaojuan Xu, Makoto Ono, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
BACKGROUND: Ryanodine receptor (RyR2) is known to be a causal gene of catecholaminergic polymorphic ventricular tachycardia (CPVT) as an important inherited disease. Some of the human CPVT-associated mutations were found in a domain (4026-4172), which has EF hand motifs; so-called calmodulin (CaM)-like domain (CaMLD). OBJECTIVE: To investigate the underlying mechanism by which CPVT is induced with mutation at CaMLD. METHODS: We newly generated N4103K/+ knock-in (KI) mice model...
February 7, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29425657/urine-metabolomics-shows-an-induction-of-fatty-acids-metabolism-in-healthy-adult-volunteers-after-supplementation-with-green-coffee-coffea-robusta-l-bean-extract
#3
Gregorio Peron, Davide Santarossa, Dario Voinovich, Stefano Dall'Acqua, Stefania Sut
BACKGROUND AND OBJECTIVE: Green coffee bean extract is used as herbal medicine or supplement for weight reduction and obesity. The active constituents are considered caffeine and chlorogenic acid (CGA) derivatives. The mode of action of CGA is still unclear and can be related to peroxisome proliferator-activated receptor α (PPAR-α) and liver X receptor Rα (LXR-α). Metabolomics may be an innovative tool for the description and discovery of the multiple target nature of such phytocomplex...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29424319/caffeine-inhibits-angiogenesis-in-human-glioblastoma-cells-via-hifs-modulation
#4
Grazia Maugeri, Agata Grazia D Amico, Daniela Maria Rasa, Salvatore Saccone, Concetta Federico, Gaetano Magro, Sebastiano Cavallaro, Velia D Agata
Caffeine represents the most used psychoactive drug in the world acting as a non-selective adenosine receptor antagonist. It exerts an anti-cancer role in glioblastoma multiforme (GBM). This neoplasia is characterized by extensive hypoxic foci triggering hypoxia-inducible factors (HIFs) expression. Among these factors, HIF-1α performs a crucial role in the induction of vascular endothelium growth factor (VEGF), a key player in angiogenesis and cell migration. In this work, we have investigated whether caffeine counteracts GBM progression by modulating hypoxic event...
February 9, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29417473/impact-of-coffee-and-cacao-purine-metabolites-on-neuroplasticity-and-neurodegenerative-disease
#5
Simonetta Camandola, Natalie Plick, Mark P Mattson
Increasing evidence suggests that regular consumption of coffee, tea and dark chocolate (cacao) can promote brain health and may reduce the risk of age-related neurodegenerative disorders. However, the complex array of phytochemicals in coffee and cacao beans and tea leaves has hindered a clear understanding of the component(s) that affect neuronal plasticity and resilience. One class of phytochemicals present in relatively high amounts in coffee, tea and cacao are methylxanthines. Among such methylxanthines, caffeine has been the most widely studied and has clear effects on neuronal network activity, promotes sustained cognitive performance and can protect neurons against dysfunction and death in animal models of stroke, Alzheimer's disease and Parkinson's disease...
February 8, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29408363/dopamine-depletion-shifts-behavior-from-activity-based-reinforcers-to-more-sedentary-ones-and-adenosine-receptor-antagonism-reverses-that-shift-relation-to-ventral-striatum-darpp32-phosphorylation-patterns
#6
Laura López-Cruz, Noemí San Miguel, Carla Carratalá-Ros, Lidón Monferrer, John D Salamone, Mercè Correa
The mesolimbic dopamine (DA) system plays a critical role in behavioral activation and effort-based decision-making. DA depletion produces anergia (shifts to low effort options) in animals tested on effort-based decision-making tasks. Caffeine, the most consumed stimulant in the world, acts as an adenosine A1/A2A receptor antagonist, and in striatal areas DA D1 and D2 receptors are co-localized with adenosine A1 and A2A receptors respectively. In the present work, we evaluated the effect of caffeine on anergia induced by the VMAT-2 inhibitor tetrabenazine (TBZ), which depletes DA...
February 2, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29401432/dynamic-and-irregular-distribution-of-ryr2-clusters-in-the-periphery-of-live-ventricular-myocytes
#7
Florian Hiess, Pascal Detampel, Carme Nolla-Colomer, Alex Vallmitjana, Anutosh Ganguly, Matthias Amrein, Henk E D J Ter Keurs, Raul Benítez, Leif Hove-Madsen, S R Wayne Chen
Cardiac ryanodine receptors (RyR2s) are Ca2+ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2+ release. The distribution of these Ca2+ release units plays a critical role in determining the spatio-temporal profile and stability of sarcoplasmic reticulum Ca2+ release. RyR2 clusters located in the interior of cardiomyocytes are arranged in highly ordered arrays. However, little is known about the distribution and function of RyR2 clusters in the periphery of cardiomyocytes...
January 23, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29399547/caffeine-neuroprotective-mechanism-against-%C3%AE-amyloid-neurotoxicity-in-shsy5y-cell-line-involvement-of-adenosine-ryanodine-and-n-methyl-d-aspartate-receptors
#8
Mojtaba Keshavarz, Majid Reza Farrokhi, Atena Amiri
Purpose: Some reports have shown neuroprotective effects of caffeine in several neurodegenerative disorders. However, its mechanism of action is not completely clear. Therefore, the aim of this study was to explore the interference of ryanodine, N-methyl-D-aspartate (NMDA) and adenosine modulators with the neuroprotective effects of caffeine against β-amyloid (Aβ) neurotoxicity in the SHSY5Y cells. Methods: The SHSY5Y cells were treated with Aβ23-35 (20µM) and/or caffeine (0.6 and 1mM), or both for 24 hours...
December 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29360435/cerebellar-oxidative-stress-and-fine-motor-impairment-in-adolescent-rats-exposed-to-hyperthermia-induced-seizures-is-prevented-by-maternal-caffeine-intake-during-gestation-and-lactation
#9
María Crespo, David Agustín León-Navarro, Mairena Martín
Febrile seizures (FS) is one of the most common convulsive disorders in infants and young children that only occurs during the first years of life in humans, when the cerebellum is still developing. Several works have shown that maternal caffeine consumption during gestation and lactation can exert protective effects on developing brain under pathological conditions. Here, we have used an animal model of FS to know whether maternal caffeine consumption during gestation and lactation exhibited protective effects on rat cerebellum...
January 19, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29327202/transient-disruption-of-adenosine-signaling-during-embryogenesis-triggers-a-pro-epileptic-phenotype-in-adult-zebrafish
#10
Fabiano Peres Menezes, Felipe Machado Torresini, Laura Roesler Nery, Rosane Souza da Silva
Adenosinergic signaling has important effects on brain function, anatomy, and physiology in both late and early stages of development. Exposure to caffeine, a non-specific blocker of adenosine receptor, has been indicated as a developmental risk factor. Disruption of adenosinergic signaling during early stages of development can change the normal neural network formation and possibly lead to an increase in susceptibility to seizures. In this work, morpholinos (MO) temporarily blocked the translation of adenosine receptor transcripts, adora1, adora2aa, and adora2ab, during the embryonic phase of zebrafish...
January 11, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29318639/interaction-between-caffeine-and-polymorphisms-of-glutamate-ionotropic-receptor-nmda-type-subunit-2a-grin2a-and-cytochrome-p450-1a2-cyp1a2-on-parkinson-s-disease-risk
#11
Iris Y Kim, Éilis J O'Reilly, Katherine C Hughes, Xiang Gao, Michael A Schwarzschild, Marjorie L McCullough, Marian T Hannan, Rebecca A Betensky, Alberto Ascherio
BACKGROUND: Caffeine intake has been inversely associated with Parkinson's disease (PD) risk. This relationship may be modified by polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2), but the results of previous studies have been inconsistent. METHOD: We examined the interaction of caffeine intake with GRIN2A-rs4998386 and CYP1A2-rs762551 polymorphisms in influencing PD risk among 829 incident cases of PD and 2,754 matched controls selected among participants in the following 3 large prospective ongoing cohorts: the Nurses' Health Study, the Health Professionals' Follow-up Study, and the Cancer Prevention Study II Nutrition Cohort...
January 10, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29310424/evodiamine-reduces-caffeine-induced-sleep-disturbances-and-excitation-in-mice
#12
Yong-Hyun Ko, Kyu-Yeon Shim, Seok-Yong Lee, Choon-Gon Jang
Worldwide, caffeine is among the most commonly used stimulatory substances. Unfortunately, significant caffeine consumption is associated with several adverse effects, ranging from sleep disturbances (including insomnia) to cardiovascular problems. This study investigates whether treatment with the Evodia rutaecarpa aqueous extract (ERAE) from berries and its major molecular component, evodiamine, can reduce the adverse caffeine-induced sleep-related and excitation effects. We combined measurements from the pentobarbital-induced sleep test, the open field test, and the locomotor activity test in mice that had been dosed with caffeine...
January 9, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29298852/serum-caffeine-and-metabolites-are-reliable-biomarkers-of-early-parkinson-disease
#13
Motoki Fujimaki, Shinji Saiki, Yuanzhe Li, Naoko Kaga, Hikari Taka, Taku Hatano, Kei-Ichi Ishikawa, Yutaka Oji, Akio Mori, Ayami Okuzumi, Takahiro Koinuma, Shin-Ichi Ueno, Yoko Imamichi, Takashi Ueno, Yoshiki Miura, Manabu Funayama, Nobutaka Hattori
OBJECTIVE: To investigate the kinetics and metabolism of caffeine in serum from patients with Parkinson disease (PD) and controls using liquid chromatography-mass spectrometry. METHODS: Levels of caffeine and its 11 metabolites in serum from 108 patients with PD and 31 age-matched healthy controls were examined by liquid chromatography-mass spectrometry. Mutations in caffeine-associated genes were screened by direct sequencing. RESULTS: Serum levels of caffeine and 9 of its downstream metabolites were significantly decreased even in patients with early PD, unrelated to total caffeine intake or disease severity...
January 30, 2018: Neurology
https://www.readbyqxmd.com/read/29295636/caffeine-prevents-bilirubin-induced-cytotoxicity-in-cultured-newborn-rat-astrocytes
#14
Mehmet Deliktaş, Hacer Ergin, Aydın Demiray, Hakan Akça, Özmert M A Özdemir, Mehmet Bülent Özdemir
OBJECTIVE: Unconjugated bilirubin (UCB) may cause neurotoxicity in preterm neonates due to immaturity of UGT1A1 leading to bilirubin accumulation in the brain. Caffeine used in the treatment of apnea of prematurity was reported to decrease mechanical ventilation requirement, the frequencies of bronchopulmonary dysplasia, patent ductus arteriosus, cerebral palsy and neurodevelopmental disorders in very low birth weight infants. However, the effect of caffeine on hyperbilirubinemia was not yet clarified...
January 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29249184/caffeine-affects-hfd-induced-hepatic-steatosis-by-multifactorial-intervention
#15
M G Helal, S E Ayoub, W F Elkashefand, T M Ibrahim
The incidence of nonalcoholic fatty liver disease (NAFLD) is considered a risk factor for hepatic fibrosis. Therefore, there is critical need to develop novel cheap and effective therapeutic approaches to prevent and reverse NAFLD. Caffeine is commonly consumed beverage and has antioxidant and anti-inflammatory activities. This study examined whether caffeine can ameliorate liver injury induced by high-fat diet (HFD) feeding. Four groups of rats were used and treated for 16 weeks as follows: control group, rats were fed a standard diet; HFD group, rats were fed HFD; and caffeine 20 and caffeine 30 groups, rats were fed HFD for 16 weeks in addition to different doses of caffeine (20 or 30 mg/kg, respectively) for last 8 weeks...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29225318/caffeine-stimulated-intestinal-epithelial-cells-suppress-lipid-accumulation-in-adipocytes
#16
Takakazu Mitani, Tomoya Nagano, Kiyonari Harada, Yoko Yamashita, Hitoshi Ashida
Caffeine is a methylxanthine derived from plant foods such as coffee beans and tea leaves, and has multiple biological activities against physiological response and several diseases. Although there are some reports about the direct effect of caffeine against anti-lipid accumulation in vitro, the effect of caffeine on lipid accumulation in adipocytes through stimulating intestinal epithelial cells is unknown. Since direct treatment with caffeine to 3T3-L1 cells did not affect lipid accumulation, we determined whether caffeine-stimulated intestinal epithelial Caco-2 cells influence the lipid accumulation in 3T3-L1 adipocytes...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29223552/caffeine-rich-infusion-from-cola-nitida-kola-nut-inhibits-major-carbohydrate-catabolic-enzymes-abates-redox-imbalance-and-modulates-oxidative-dysregulated-metabolic-pathways-and-metabolites-in-fe2-induced-hepatic-toxicity
#17
Ochuko L Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A Koorbanally, Md Shahidul Islam
The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at <50°C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p<0.05) scavenging 2,2'-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p<0.05) inhibited α-glucosidase and α-amylase activities...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29212769/functional-and-structural-characterization-of-a-novel-malignant-hyperthermia-susceptible-variant-of-dhpr-%C3%AE-1a-subunit-cacnb1
#18
Claudio F Perez, Jose M Eltit, Jose R Lopez, Dóra Bodnár, Angela F Dulhunty, Shouvik Aditya, Marco G Casarotto
Malignant Hyperthermia (MH) susceptibility has been recently linked to a novel variant of β1a subunit of the dihydropyridine receptor (DHPR), a channel essential for Ca2+ regulation in skeletal muscle. Here we evaluate the effect of the mutant variant V156A on the structure/function of DHPR β1a subunit and assess its role on Ca2+ metabolism of cultured myotubes. Using differential scanning fluorimetry we show that mutation V156A causes a significant reduction in thermal stability of the Src homology 3 (SH3)/Guanylate Kinase (GK) core domain of β1a subunit...
December 6, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29198059/metabolic-effects-of-physiological-levels-of-caffeine-in-myotubes
#19
Jamie K Schnuck, Lacey M Gould, Hailey A Parry, Michele A Johnson, Nicholas P Gannon, Kyle L Sunderland, Roger A Vaughan
Caffeine has been shown to stimulate multiple major regulators of cell energetics including AMP-activated protein kinase (AMPK) and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Additionally, caffeine induces peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and mitochondrial biogenesis. While caffeine enhances oxidative metabolism, experimental concentrations often exceed physiologically attainable concentrations through diet. This work measured the effects of low-level caffeine on cellular metabolism and gene expression in myotubes, as well as the dependence of caffeine's effects on the nuclear receptor peroxisome proliferator-activated receptor beta/delta (PPARβ/δ)...
December 3, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29193528/-epicatechin-induced-relaxation-of-isolated-human-saphenous-vein-roles-of-k-and-ca2-channels
#20
Marija Marinko, Goran Jankovic, Dragoslav Nenezic, Predrag Milojevic, Ivan Stojanovic, Vladimir Kanjuh, Aleksandra Novakovic
In this study, we aimed to investigate relaxant effect of flavanol (-)-epicatechin on the isolated human saphenous vein (HSV), as a part of its cardioprotective action, and to define the mechanisms underlying this vasorelaxation. (-)-Epicatechin induced a concentration-dependent relaxation of HSV pre-contracted by phenylephrine. Among K+ channel blockers, 4-aminopyridine, margatoxin, and iberiotoxin significantly inhibited relaxation of HSV, while glibenclamide considerably reduced effects of the high concentrations of (-)-epicatechin...
November 29, 2017: Phytotherapy Research: PTR
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