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https://www.readbyqxmd.com/read/28918200/profiling-the-short-linear-non-disulfide-bond-containing-peptidome-from-the-venom-of-the-scorpion-tityus-obscurus
#1
Nathalia Baptista Dias, Bibiana Monson de Souza, Fernando Kamimura Cocchi, Hipócrates M Chalkidis, Valquíria Abrão Coronado Dorce, Mario Sergio Palma
Many scorpion accidents occur in the Brazilian Amazonian region and are frequently caused by Tityus obscurus. Approximately 5% of the crude venom of this species is composed of short linear, non-disulfide-bridged peptides, which have not been intensively investigated. As a consequence, only a few of these peptides have been structurally and functionally characterized to date. In the present paper, the peptide fraction of the venom was subjected to peptide profiling using an LCMS-IT-TOF/MS and MS(n) system. The analysis detected 320 non-disulfide bond-containing peptides (NDBPs), of which twenty-seven had their sequences assigned; among them, thirteen peptides were characterized, constituting novel toxins in T...
September 13, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28912585/matrisome-profiling-during-intervertebral-disc-development-and-ageing
#2
Joana Caldeira, Cátia Santa, Hugo Osório, Maria Molinos, Bruno Manadas, Raquel Gonçalves, Mário Barbosa
Intervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investigation. However, a thorough study of ECM profiling is needed, to better understand IVD development and age-associated degeneration. As so, iTRAQ LC-MS/MS analysis of foetus, young and old bovine NPs, was performed to define the NP matrisome...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910372/correlation-of-serum-cartilage-oligometric-matrix-protein-comp-and-interleukin-16-il-16-levels-with-disease-severity-in-primary-knee-osteoarthritis-a-pilot-study-in-a-malaysian-population
#3
Esha Das Gupta, Wei Ren Ng, Shew Fung Wong, Abdul Kareem Bhurhanudeen, Swan Sim Yeap
OBJECTIVE: The aim of this study was to investigate the correlations between serum cartilage oligomeric matrix protein (COMP), interleukin-16 (IL-16) and different grades of knee osteoarthritis (KOA) in Malaysian subjects. METHODS: Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K-L) grade 2 KOA, 27 with K-L grade 3 KOA, 7 with grade 4 KOA, and 30 healthy controls. All subjects completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28910133/a-comparison-of-2-year-outcomes-in-patients-undergoing-tibiofemoral-or-patellofemoral-matrix-induced-autologous-chondrocyte-implantation
#4
Jay R Ebert, Adrian Schneider, Michael Fallon, David J Wood, Gregory C Janes
BACKGROUND: Matrix-induced autologous chondrocyte implantation (MACI) has demonstrated encouraging clinical results in the treatment of knee chondral defects. However, earlier studies suggested that chondrocyte implantation in the patellofemoral (PF) joint was less effective than in the tibiofemoral (TF) joint. PURPOSE: To compare the radiological and clinical outcomes of those undergoing MACI to either the femoral condyles or PF joint. STUDY DESIGN: Cohort study; Level of evidence, 3...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28906396/chondrosarcoma-of-the-patella-a-case-report
#5
Conglin Ye, Zhiping Luo, Jin Zeng, Min Dai
RATIONALE: Chondrosarcoma, characterized by the production of cartilage matrix, is a common bone tumor, accounting for 20% to 27% of all malignant bone tumors. It often occurs in the cartilage of the pelvis, femur, tibia, and humerus. However, chondrosarcoma of the patella is extremely rare. PATIENT CONCERNS: The present study describes a case of chondrosarcoma affecting the right patella in a 68-year-old woman. The chief complaints were painful swelling and limitation of motion of the right knee for about half a year...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28905805/a-novel-model-of-acellular-dermal-matrix-plug-for-anal-fistula-treatment-report-of-a-case-and-surgical-consideration-based-on-first-utility-in-poland
#6
Adam Bobkiewicz, Łukasz Krokowicz, Maciej Borejsza-Wysocki, Tomasz Banasiewicz
Anal fistula (AF) is a pathological connection between anus and skin in its surroundings. The main reason for the formation of anal fistula is a bacterial infection of the glands within the anal crypts. One of the modern techniques for the treatment of fistulas that do not interfere with the sphincters consists in implantation of a plug made from collagen material. We are presenting the first Polish experience with a new model of biomaterial plug for the treatment of anal fistula. We also point out key elements of the procedure (both preoperative and intraoperative) associated with this method...
August 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28904559/cartilage-protection-and-analgesic-activity-of-a-botanical-composition-comprised-of-morus-alba-scutellaria-baicalensis-and-acacia-catechu
#7
Mesfin Yimam, Teresa Horm, Laura Wright, Ping Jiao, Mei Hong, Lidia Brownell, Qi Jia
Although there have been augmented advances in drug discovery, current OA management is inadequate due to the lack of successful therapies proven to be effective in modifying disease progression. For some, the risk outweighs the benefit. As a result, there is a desperate need for safe and efficacious natural alternatives. Here we evaluated a composition from Morus alba, Scutellaria baicalensis, and Acacia catechu in maintaining joint structural integrity and alleviating OA associated symptoms in monoiodoacetate- (MIA-) induced rat OA disease model...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28902818/-efficacy-of-sulodexide-in-treatment-of-chronic-venous-insufficiency-results-of-the-accord-trial
#8
V Iu Bogachev, O V Golovanova, I N Malysheva
OBJECTIVE: The purpose of our study was to evaluate both clinical and laboratory efficacy of sulodexide given at a daily dose of 500 lipasemic units (LSU) in patients presenting with class C3-C4 chronic venous insufficiency (CVI) according to the CEAP classification. PATIENTS AND METHODS: The study included a total of 25 patients diagnosed with C3-C4 CVI and prescribed to receive sulodexide at a daily dose of 500 LSU for 90 days. Efficacy was comprehensively controlled by the following tools: the disease-specific Chronic Venous Insufficiency Quality of Life Questionnaire (CIVIQ), visual-analogue methods of assessment separate symptoms; the Venous Clinical Severity Score (VCSS), as well as ultrasonographic determination of the thickness of subcutaneous fat and crural fascia...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28894662/acellular-dermal-matrix-treating-periocular-melanoma-in-a-patient-with-xeroderma-pigmentosa
#9
Kamlen Pillay, Saleigh Adams, Laura Vandermaesen, Donald Anthony Hudson
We report a 7-year-old girl with xeroderma pigmentosum (XP), who presented in our clinic with a large melanoma (35 × 50 × 20 mm, Breslow depth 18 mm) in the zygomatic-malar area. Palliative surgery was performed to maintain her residual vision and to reduce the pain caused by the compression of local structures. Because of the limited access of autologous skin grafts in pediatric patients with XP who are severely affected, we opted to use an acellular dermal matrix. There was 100% graft uptake, and the pain due to compression by the tumor was alleviated...
August 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28892591/a-pilot-dose-finding-study-of-etanercept-in-rheumatoid-arthritis
#10
Ferdinand C Breedveld, Heather E Jones, Kim Peifer, Joan Korth-Bradley
A randomized, parallel-dose study assessed the pharmacokinetics (PK) and pharmacodynamics (PD) of etanercept in 61 patients with rheumatoid arthritis (RA) who received doses from 10 mg once-weekly to 50 mg twice-weekly for 4 weeks. Empiric application of a maximal-effect (Emax ) model to pooled steady-state concentrations (Css ) and PD markers provided half-maximal-effect concentration estimates of 567, 573, 465, 87, and 159 ng/mL for change from baseline in number of swollen joints, number of painful joints, erythrocyte sedimentation rate, interleukin-6, and matrix metalloproteinase-3, respectively...
September 11, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28891499/astroglial-hydro-ionic-waves-guided-by-the-extracellular-matrix-an-exploratory-model
#11
Alfredo Pereira
Calcium waves are generated from the astrocyte endoplasmatic reticulum, in response to neuronal electrochemical stimulation. The waves feed back on neurons, modulating (reinforcing or depressing) their activity and the resulting behavior. How do these waves propagate from the astrocyte endoplasmatic reticulum to the synaptic space and reach neuron membrane channels? An exploratory model is elaborated, on the basis of complex interactions of ions, water negative exclusion zones and charged sites of proteins...
2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28888300/heterotopic-ossification-and-hypertrophic-scars
#12
REVIEW
Shailesh Agarwal, Michael Sorkin, Benjamin Levi
Burns and trauma cause superficial and deep soft tissue wounds that cannot heal to the preinjury state. Healing requires cell proliferation and differentiation into the injured tissue type, laying down extracellular matrix, often as collagens. Heterotopic ossification causes severe pain, nonhealing wounds, and restricted range of motion. Treatment includes radiation therapy, nonsteroidal anti-inflammatory drugs, bisphosphonates, and possibly surgical excision and prophylactic measures. Hypertrophic scars, nonosseous lesions caused by excessive collagen deposition, are often painful, functionally limiting, and aesthetically displeasing...
October 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28874080/low-molecular-weight-gel-fraction-of-aloe-vera-exhibits-gastroprotection-by-inducing-matrix-metalloproteinase-9-inhibitory-activity-in-alcohol-induced-acute-gastric-lesion-tissues
#13
Chul-Hong Park, Hyeong-U Son, Chi-Yeol Yoo, Sang-Han Lee
CONTEXT: Aloe has been used for the prevention and cure of various diseases and symptoms including burns, injuries, oedema and pain. OBJECTIVE: This study determines the specific inhibitory activity of matrix metalloproteinase (MMP)-9 induced by the low molecular-weight gel fraction of Aloe vera (L.) Burm.f. (lgfAv) on alcohol-induced acute gastric lesions. MATERIALS AND METHODS: We examined the protective effects of oral (p.o.) administration of lgfAv (molecular weight cutoff <50...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28872119/intravital-microscopy-of-monocyte-homing-and-tumor-related-angiogenesis-in-a-murine-model-of-peripheral-arterial-disease
#14
Martin Wagner, Claudia Baer, Werner Zuschratter, Monika Riek-Burchardt, Christian Deffge, Soenke Weinert, Jerry C Lee, Ruediger C Braun-Dullaeus, Joerg Herold
The therapeutic goal for peripheral arterial disease and ischemic heart disease is to increase blood flow to ischemic areas caused by hemodynamic stenosis. Vascular surgery is a viable option in selected cases, but for patients without indications for surgery such as progression to rest pain, critical limb ischemia, or major disruptions to life or work, there are few possibilities for mitigating their disease. Cell therapy via monocyte-enhanced perfusion through the stimulation of collateral formation is one of a few non-invasive options...
August 26, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28866752/altered-associations-between-pain-symptoms-and-brain-morphometry-in-the-pain-matrix-of-hiv-seropositive-individuals
#15
Deborrah Castillo, Thomas Ernst, Eric Cunningham, Linda Chang
Pain remains highly prevalent in HIV-seropositive (HIV+) patients despite their well-suppressed viremia with combined antiretroviral therapy. Investigating brain abnormalities within the pain matrix, and in relation to pain symptoms, in HIV+ participants may provide objective biomarkers and insights regarding their pain symptoms. We used Patient-Reported Outcome Measurement Information System (PROMIS®) pain questionnaire to evaluate pain symptoms (pain intensity, pain interference and pain behavior), and structural MRI to assess brain morphometry using FreeSurfer (cortical area, cortical thickness and subcortical volumes were evaluated in 12 regions within the pain matrix)...
September 2, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28866193/injectable-natural-polymer-compound-for-tissue-engineering-of-intervertebral-disc-in-vitro-study
#16
Masoud Ghorbani, Jafar Ai, Mohammad Reza Nourani, Mahmoud Azami, Batool Hashemi Beni, Shiva Asadpour, Sima Bordbar
Intervertebral disc degeneration is recognized to be the leading cause for chronic low-back pain. Injectable hydrogel is one of the great interests for tissue engineering and cell encapsulation specially for intervertebral (IVD) affecting rate of regeneration success, in this study we assessed viscoelastic properties of a Chitosan-β glycerophosphate-hyaluronic acid, Chondroitin-6-sulfate, type 2 of Collagen, gelatin, fibroin silk (Ch-β-GP-HA-CS-Col-Ge-FS) hydrogel which was named as NP hydrogel that is natural extracellular matrix of IVD...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865377/assessing-pain-in-patients-with-chronic-disorders-of-consciousness-are-we-heading-in-the-right-direction
#17
Antonino Naro, Placido Bramanti, Alessia Bramanti, Rocco Salvatore Calabrò
The deterioration of sensory-motor integration within the pain matrix in patients with chronic Disorders of Consciousness (DoC) is one of the principal mechanisms responsible for non-conscious pain perception. The present study aimed to assess whether the variability in the inter-peak interval (IPI) between the N2 and P2 components of laser evoked potentials (LEP) could represent an objective marker of the behavioral responsiveness to nociceptive stimulation, as measured by the Nociception Coma Scale-Revised (NCS-R), and regardless of the sensory part of pain processing...
August 30, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28860852/expression-of-matrix-metalloproteinases-and-components-of-the-endocannabinoid-system-in-the-knee-joint-are-associated-with-biphasic-pain-progression-in-a-rat-model-of-osteoarthritis
#18
Agnieszka Pajak, Magdalena Kostrzewa, Natalia Malek, Michal Korostynski, Katarzyna Starowicz
Matrix metalloproteinases (MMPs) are considered important in articular cartilage breakdown during osteoarthritis (OA). Similarly, the endocannabinoid system (ECS) is implicated in joint function and modulation of nociceptive processing. Functional interplay between ECS and MMPs has been recently indicated. Here, we tested if changes in the expression of selected MMPs and major ECS elements temporally correlate with the intensity of OA-related pain. Knee OA was induced in male Wistar rats by intra-articular sodium monoiodoacetate injection...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28859670/selective-suppression-of-the-jnk-mmp2-9-signal-pathway-by-tetramethylpyrazine-attenuates-neuropathic-pain-in-rats
#19
Lai Jiang, Cai-Long Pan, Chao-Yu Wang, Bing-Qian Liu, Yuan Han, Liang Hu, Lei Liu, Yang Yang, Jun-Wei Qu, Wen-Tao Liu
BACKGROUND: Activated astrocytes release matrix metalloproteinase-2/9 (MMP-2/9) to induce central sensitization and maintain neuropathic pain. However, the mechanisms involved in the activation of MMP-2/9 on astrocytes during pain remain poorly understood. Meanwhile, there is a lack of effective treatment to inhibit the activation of MMP-2/9 on astrocytes. In this study, we aim to investigate the effect of tetramethylpyrazine (TMP), a natural compound with analgesic effects but unknown mechanisms, on MMP-2/9 in neuropathic pain...
August 31, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28858038/liver-fibrosis-quantification-by-magnetic-resonance-imaging
#20
Léonie Petitclerc, Guillaume Gilbert, Bich N Nguyen, An Tang
Liver fibrosis is a hallmark of chronic liver disease characterized by the excessive accumulation of extracellular matrix proteins. Although liver biopsy is the reference standard for diagnosis and staging of liver fibrosis, it has some limitations, including potential pain, sampling variability, and low patient acceptance. Hence, there has been an effort to develop noninvasive imaging techniques for diagnosis, staging, and monitoring of liver fibrosis. Many quantitative techniques have been implemented on magnetic resonance imaging (MRI) for this indication...
August 28, 2017: Topics in Magnetic Resonance Imaging: TMRI
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