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https://www.readbyqxmd.com/read/29333517/safety-and-feasibility-of-platelet-rich-fibrin-matrix-injections-for-treatment-of-common-urologic-conditions
#1
Ethan L Matz, Amy M Pearlman, Ryan P Terlecki
Purpose: Autologous platelet rich plasma (PRP) is used increasingly in a variety of settings. PRP injections have been used for decades to improve angiogenesis and wound healing. They have also been offered commercially in urology with little to no data on safety or efficacy. PRP could theoretically improve multiple urologic conditions, such as erectile dysfunction (ED), Peyronie's disease (PD), and stress urinary incontinence (SUI). A concern with PRP, however, is early washout, a situation potentially avoided by conversion to platelet rich fibrin matrix (PRFM)...
January 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29325937/histopathological-analysis-of-tamoxifen-on-epidural-fibrosis
#2
Yasar Ozturk, Ismail Bozkurt, Mesut Emre Yaman, Yahya Guvenc, Tolga Tolunay, Deniz Billur, Fatma Kubra Erbay, Salim Senturk, Gokhan Bozkurt
BACKGROUND: Epidural fibrosis is a challenging topic in spinal surgery. This phenomenon constitutes one of the the main reasons behind "post-laminectomy syndrome" or "failed-back surgery syndrome", which leads to persistent back and leg pain in association with compression and/or stretching the nerve root or the dura. The exact mechanism of action in epidural fibrosis is complex and remains uncertain. Excessive deposition of collagen, fibronectin, and dermatan sulfate known as "extracellular matrix", and decrease of tissue cellularity results in epidural fibrosis...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29318405/the-efficacy-of-a-porcine-collagen-matrix-in-keratinized-tissue-augmentation-a-5-year-follow-up-study
#3
C Maiorana, L Pivetti, F Signorino, G B Grossi, A S Herford, M Beretta
BACKGROUND: When keratinized tissue width around dental implants is poorly represented, the clinician could resort to autogenous soft tissue grafting. Autogenous soft tissue grafting procedures are usually associated with a certain degree of morbidity. Collagen matrices could be used as an alternative to reduce morbidity and intra-operatory times. The aim of this study was to assess the efficacy of a xenogeneic collagen matrix as a substitute for soft tissue grafting around dental implants...
January 10, 2018: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/29314655/randomised-controlled-trial-of-standard-closure-of-stoma-site-versus-biologic-mesh-reinforcement-study-protocol-of-the-rocss-trial
#4
(no author information available yet)
BACKGROUND: Closure of complex and contaminated abdominal wounds is challenging and carries risks, including wound dehiscence and incisional hernias. Hernia formation at closed stoma sites occurs in up to 30% of patients. Use of biological meshes in these situations may provide a safe method of reducing these complications, especially long-term incisional hernias. METHOD: The Reinforcement of Closure of Stoma Site (ROCSS) study is a phase III multicentre randomised controlled trial (RCT), with an internal feasibility study...
January 3, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29313174/polar-extract-of-curcuma-longa-protects-cartilage-homeostasis-possible-mechanism-of-action
#5
Chandrasekaran Chinampudur Velusami, Edwin Jothie Richard, Bharathi Bethapudi
BACKGROUND: Curcuma longa has been well documented for managing joint inflammation and pain. The present study investigated the effect of polar extract of C. longa (NR-INF-02) on cartilage homeostasis in human articular chondrocytes knee (NHAC-kn) cells to understand its plausible mechanism of action. METHODS: Dysregulation of cartilage homeostasis was induced by IL-1β and H2O2. Modulating effects of NR-INF-02 on degradation markers viz., chondrocyte apoptosis, senescence, cytokine, eicosanoids, and cartilage synthesis markers viz...
January 8, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29310703/management-of-persistent-epistaxis-using-floseal-hemostatic-matrix-vs-traditional-nasal-packing-a-prospective-randomized-control-trial
#6
Scott Murray, Adrian Mendez, Alexander Hopkins, Hamdy El-Hakim, Caroline C Jeffery, David W J Côté
BACKGROUND: Epistaxis is the most common emergent consultation to otolaryngology-head & neck surgery (OHNS) and with 60% of the population having experienced an episode and 1.6 in 10,000 requiring hospitalization in their lifetime. In preliminary studies Floseal® (Baxter, USA) Hemostatic Matrix has shown efficacy in up to 80% of persistent anterior epistaxis. We sought to evaluate the clinical efficacy and cost-effectiveness of Floseal® (Baxter, USA) compared to traditional nasal packing for persistent epistaxis...
January 8, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29303407/vaginoplasty-with-acellular-dermal-matrix-after-radical-resection-for-carcinoma-of-the-uterine-cervix
#7
Zhi Wang, Jiuzuo Huang, Ang Zeng, Ming Wu, Xiaojun Wang
Various methods are available for vaginoplasty, but many of them have the drawbacks including surgical complexity and postoperative pain at the donor site. We herein evaluated the outcomes of vaginoplasty using tissue-engineered biomaterial graft. This study included 16 early stage cervical cancer patients who received curative surgery in combination with radiotherapy. They underwent vaginoplasty with tissue-engineered biological material, acellular dermal matrix (ADM). After treatment, a vaginal dilator was advised to be used for 6 months to prevent contraction of vagina...
January 5, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29301093/biomolecules-in-the-treatment-of-lichen-planus-refractory-to-corticosteroid-therapy-clinical-and-histopathological-assessment
#8
Laura Piñas, Mohammad Hamdan Alkhraisat, Ricardo Suárez Fernández, Eduardo Anitua
BACKGROUND: Local deficit of several biomolecules have been described in oral lichen planus (OLP). Such a deficit impairs cellular functions and cell-matrix communication. PURPOSE: Assess the efficacy of the local application of autologous biomolecules in the treatment of erosive OLP. MATERIALS AND METHODS: In this study, the use of plasma rich in growth factors (PRGF) as a source of blood-derived and autologous growth factors and proteins were tested in erosive oral lichen planus refractory to corticosteroids...
January 1, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29287951/the-effect-of-platelet-rich-fibrin-matrix-at-the-time-of-gluteus-medius-repair-a-retrospective-comparative-study
#9
Bryan M Saltzman, Gift Ukwuani, Eric C Makhni, Jeffrey P Stephens, Shane J Nho
PURPOSE: To evaluate the effect of platelet-rich fibrin matrix (PRFM) on outcomes after surgical repair of gluteus medius tendons. METHODS: This is a retrospective review of prospectively collected data comparing patients who underwent gluteus medius repair with PRFM and patients without PRFM. Preoperative characteristics, intraoperative characteristics, and postoperative outcomes at a minimum of 1 year were recorded. Statistical analysis was performed using a multivariate analysis of variance to test for differences in continuous demographic variables and postoperative-only scores between patient groups, χ2 tests were performed for categorical variables, and a repeated-measures analysis of variance was performed to test for the effects of PRFM...
December 26, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29285575/alteration-of-gray-matter-texture-features-over-the-whole-brain-in-medication-overuse-headache-using-a-3-dimentional-texture-analysis
#10
Zhiye Chen, Xiaoyan Chen, Zhiqiang Chen, Mengqi Liu, Huiguang He, Lin Ma, Shengyuan Yu
BACKGROUND: Imaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR structural images over the whole brain in MOH using a 3-dimentional texture analysis. METHODS: Brain three-dimensional T1-weighted structural images were obtained from 44 MOH patients and 32 normal controls (NC). The imaging processing included two steps: gray matter (gray images) segment and a 3-dimensional texture features mapping...
November 28, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29279966/betulinic-acid-alleviates-dextran-sulfate-sodium-induced-colitis-and-visceral-pain-in-mice
#11
Jaspreet Kalra, Madhu Cholenahalli Lingaraju, Karikalan Mathesh, Dhirendra Kumar, Subhashree Parida, Thakur Uttam Singh, Anil Kumar Sharma, Dinesh Kumar, Surendra Kumar Tandan
Betulinic acid (BA) exhibits many biological effects including anti-inflammatory and anti-oxidant activities. Free radicals and pro-inflammatory mediators play an important role in the pathology of inflammatory bowel disease (IBD) and associated pain. We, therefore, examined the anti-oxidant, anti-inflammatory, and anti-nociceptive potential of BA in colitis. Colitis was induced with 3% (w/v) dextran sulfate sodium (DSS) in drinking water in mice for 1to7 days. BA (3, 10 and 30 mg/kg) was given orally for 0 to 7 days...
December 26, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29278537/return-to-sport-after-arthroscopic-autologous-matrix-induced-chondrogenesis-for-patients-with-osteochondral-lesion-of-the-talus
#12
Riccardo DʼAmbrosi, Jorge H Villafañe, Cristian Indino, Federico M Liuni, Pedro Berjano, Federico G Usuelli
OBJECTIVE: To determine the rate of return of patients to sport after arthroscopic autologous matrix-induced chondrogenesis (AT-AMIC) for outcomes 2 years after surgery. DESIGN: Retrospective observational cross-sectional study. SETTING: C.A.S.C.O.-Foot and Ankle Unit, Istituto Ortopedico Galeazzi, Milan, Italy. PATIENTS AND INTERVENTION: Twenty-six consecutive patients, 65.4% male (mean ± SD age: 33.7 ± 11.0 years), that underwent AT-AMIC procedure between 2012 and 2015 were selected retrospectively...
December 22, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29276401/cohesive-polydensified-matrix%C3%A2-hyaluronic-acid-volumizer-injected-for-cheek-augmentation-has-additional-positive-effect-on-nasolabial-folds
#13
Gerd Gauglitz, Stephanie Steckmeier, Julian Pötschke, Hannah Schwaiger
Purpose: Cohesive Polydensified Matrix® hyaluronic acid (CPM-HA) volumizer has been used successfully for several years to reverse biometric volume loss during facial aging. This observational study explored the additive effect on nasolabial folds when CPM-HA volumizer is injected into the neighboring cheek area. Patients and methods: In this open-label, prospective, postmarketing noninterventional study, 18 adult patients seeking esthetic enhancement of the lateral cheek hollows and cheekbone area were injected with CPM-HA volumizer integrated with lidocaine (CPM-HA-VL) in the upper or lower cheek area...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29275104/one-step-prepectoral-breast-reconstruction-with-dermal-matrix-covered-implant-compared-to-submuscular-implantation-functional-and-cost-evaluation
#14
Leonardo Cattelani, Susanna Polotto, Maria Francesca Arcuri, Giuseppe Pedrazzi, Chiara Linguadoca, Elena Bonati
BACKGROUND: The breast reconstructive subpectoral technique commonly leads to functional consequences. Recently, a new conservative prepectoral breast reconstruction (PPBR) technique was proposed and its surgical safety and aesthetic effectiveness proved. The aim of this prospective nonrandomized study was to compare the functional and economical outcomes of the PPBR procedure versus the subpectoral one. PATIENTS AND METHODS: From February 2015 to September 2016, 86 patients underwent mastectomy with immediate implant-based reconstruction...
December 2, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29258883/cartilage-regeneration-and-ageing-targeting-cellular-plasticity-in-osteoarthritis
#15
REVIEW
Marta Varela-Eirin, Jesus Loureiro, Eduardo Fonseca, Silvia Corrochano, Jose R Caeiro, Manuel Collado, Maria D Mayan
Ageing processes play a major contributing role for the development of Osteoarthritis (OA). This prototypic degenerative condition of ageing is the most common form of arthritis and is accompanied by a general decline, chronic pain and mobility deficits. The disease is primarily characterized by articular cartilage degradation, followed by subchondral bone thickening, osteophyte formation, synovial inflammation and joint degeneration. In the early stages, osteoarthritic chondrocytes undergo phenotypic changes that increase cell proliferation and cluster formation and enhance the production of matrix-remodelling enzymes...
December 16, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/29244889/elderly-patients-with-ongoing-migraine-show-reduced-gray-matter-volume-in-second-somatosensory-cortex
#16
Sébastien Celle, Christelle Créac'h, Claire Boutet, Frédéric Roche, Florian Chouchou, Jean-Claude Barthélémy, Roland Peyron
AIMS: To identify structural changes in gray matter in suspected migraine generators (the hypothalamus and/or brainstem nuclei) and pain pathways and to evaluate whether structural changes in migraine are definitive or resolve with age. METHODS: Voxel-based morphometry (VBM) was used to assess differences in gray matter between 39 healthy controls (HC), 25 episodic migraine (EM) subjects, and 37 subjects with a history of migraine (HM). In addition, morphometric changes were specifically investigated in suspected migraine generators and/or pain pathways...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29238818/multiscale-poroviscoelastic-compressive-properties-of-mouse-supraspinatus-tendons-are-altered-in-young-and-aged-mice
#17
Brianne Connizzo, Alan Grodzinsky
Rotator cuff disorders are one of the most common causes of shoulder pain and disability in the aging population but, unfortunately, the etiology is still unknown. One factor thought to contribute to the progression of disease is the external compression of the rotator cuff tendons, which can be significantly increased by age-related changes such as muscle weakness and poor posture. The objective of this study was to investigate the baseline compressive response of tendon and determine how this response is altered during maturation and aging...
December 13, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29238155/postoperative-pain-after-single-site-versus-multiport-hysterectomy
#18
Chris Kliethermes, Kelly Blazek, Kausar Ali, J Biba Nijjar, Stephanie Kliethermes, Xiaoming Guan
Background and Objectives: With advances in laparoscopic surgery, the goal of surgeons and patients is to minimize pain to allow for faster recovery and return to normal daily activities. One of these advances is single-site surgery. In this study, we compared postoperative pain in laparoendoscopic single-site surgery (LESS) to that in traditional multiple-incision hysterectomy. Methods: Seventy patients were selected for this prospective cohort study, with 35 undergoing multiple-incision and 35 undergoing LESS hysterectomy...
October 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/29237464/tlr3-promotes-mmp-9-production-in-primary-human-airway-epithelial-cells-through-wnt-%C3%AE-catenin-signaling
#19
P-J Royer, K Henrio, M Pain, J Loy, A Roux, A Tissot, P Lacoste, C Pison, S Brouard, A Magnan
BACKGROUND: Airway epithelial cells (AEC) act as the first line of defence in case of lung infections. They constitute a physical barrier against pathogens and they participate in the initiation of the immune response. Yet, the modalities of pathogen recognition by AEC and the consequences on the epithelial barrier remain poorly documented. METHOD: We investigated the response of primary human AEC to viral (polyinosinic-polycytidylic acid, poly(I:C)) and bacterial (lipopolysaccharide, LPS) stimulations in combination with the lung remodeling factor Transforming Growth Factor-β (TGF-β)...
December 13, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29234845/eanm-guideline-for-radionuclide-therapy-with-radium-223-of-metastatic-castration-resistant-prostate-cancer
#20
Thorsten D Poeppel, Daria Handkiewicz-Junak, Michael Andreeff, Alexander Becherer, Andreas Bockisch, Eva Fricke, Lilli Geworski, Alexander Heinzel, Bernd J Krause, Thomas Krause, Markus Mitterhauser, Wilfried Sonnenschein, Lisa Bodei, Roberto C Delgado-Bolton, Michael Gabriel
Radium Ra-223 dichloride (radium-223, Xofigo®) is a targeted alpha therapy approved for the treatment of castration-resistant prostate cancer (CRPC) with symptomatic bone metastases and no known visceral metastatic disease. Radium-223 is the first targeted alpha therapy in this indication providing a new treatment option, with evidence of a significant survival benefit, both in overall survival and in the time to the first symptomatic skeletal-related event. The skeleton is the most common metastatic site in patients with advanced prostate cancer...
December 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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