Anna Lia, Tiziana Annese, Marco Fornaro, Margherita Giannini, Dario D'Abbicco, Mariella Errede, Loredana Lorusso, Angela Amati, Marilina Tampoia, Maria Trojano, Daniela Virgintino, Domenico Ribatti, Luigi Serlenga, Florenzo Iannone, Francesco Girolamo
OBJECTIVES: To study the phenotype of macrophage infiltrates and their role in angiogenesis in different idiopathic inflammatory myopathies (IIMs). METHODS: The density and distribution of the subpopulations of macrophages subsets (M1, inducible nitric oxide+, CD11c+; M2, arginase-1+), endomysial capillaries (CD31+, FLK1+), degenerating (C5b-9+) and regenerating (NCAM+) myofibres were investigated by immunohistochemistry in human muscle samples of diagnostic biopsies from a large cohort of untreated patients (n: 81) suffering from anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR)+ immune mediated necrotizing myopathy (IMNM), anti-signal recognition particle (anti-SRP)+ IMNM, seronegative IMNM, DM, PM, PM with mitochondrial pathology, sporadic IBM, scleromyositis, and anti-synthetase syndrome...
August 3, 2022: Rheumatology