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Neonatal MRI

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https://www.readbyqxmd.com/read/29793060/a-computational-framework-for-the-detection-of-subcortical-brain-dysmaturation-in-neonatal-mri-using-3d-convolutional-neural-networks
#1
Rafael Ceschin, Alexandria Zahner, William Reynolds, Jenna Gaesser, Giulio Zuccoli, Cecilia W Lo, Vanathi Gopalakrishnan, Ashok Panigrahy
Deep neural networks are increasingly being used in both supervised learning for classification tasks and unsupervised learning to derive complex patterns from the input data. However, the successful implementation of deep neural networks using neuroimaging datasets requires adequate sample size for training and well-defined signal intensity based structural differentiation. There is a lack of effective automated diagnostic tools for the reliable detection of brain dysmaturation in the neonatal period, related to small sample size and complex undifferentiated brain structures, despite both translational research and clinical importance...
May 21, 2018: NeuroImage
https://www.readbyqxmd.com/read/29790784/neonatal-pulmonary-mri-of-bronchopulmonary-dysplasia-predicts-short-term-clinical-outcomes
#2
Nara S Higano, David R Spielberg, Robert J Fleck, Andrew H Schapiro, Laura L Walkup, Andrew D Hahn, Jean A Tkach, Paul S Kingma, Stephanie L Merhar, Sean B Fain, Jason C Woods
RATIONALE: Bronchopulmonary dysplasia (BPD) is a serious neonatal pulmonary condition associated with premature birth, but the underlying parenchymal disease and trajectory are poorly characterized. The current NICHD/NHLBI definition of BPD severity is based on degree of prematurity and extent of oxygen requirement. However, no clear link exists between initial diagnosis and clinical outcomes. OBJECTIVES: We hypothesized that magnetic resonance imaging (MRI) of structural parenchymal abnormalities will correlate with NICHD-defined BPD disease severity and predict short-term respiratory outcomes...
May 23, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29787864/the-neonatal-brain-in-critical-congenital-heart-disease-insights-and-future-directions
#3
REVIEW
Shabnam Peyvandi, Beatrice Latal, Steven P Miller, Patrick S McQuillen
Neurodevelopmental outcomes are impaired in survivors of critical congenital heart disease (CHD) in several developmental domains including motor, cognitive and sensory outcomes. These deficits can extend into the adolescent and early adulthood years. The cause of these neurodevelopmental impairments is multi-factorial and includes patient specific risk factors, cardiac anatomy and physiology as well as brain changes seen on MRI. Advances in imaging techniques have identified delayed brain development in the neonate with critical CHD as well as acquired brain injury...
May 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29777345/placenta-accreta-and-balloon-catheterization-the-experience-of-a-single-center-and-an-update-of-latest-evidence-of-literature
#4
Ferdinando Antonio Gulino, F Di Guardo, E Zambrotta, L M Di Gregorio, Andrea Miranda, Stella Capriglione, M A Palumbo
PURPOSE: We studied the efficacy of using pre-cesarean delivery (CD) temporary occlusion of internal iliac arteries with balloon catheters in case of placenta previa-accreta in terms of maternal and neonatal outcomes and to test accuracy of ultrasound (US) and magnetic resonance imaging (MRI) for prenatal diagnosis. METHODS: From March 2014 to January 2018, women with an US and/or MRI diagnosis of placenta previa-accreta and a planned delivery were enrolled and divided into two groups: balloon catheterization group (women treated with preoperative catheters and CD) and control group (women candidates to elective CD)...
May 18, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29777174/how-does-blood-regulate-cerebral-temperatures-during-hypothermia
#5
Stephen Blowers, Ian Marshall, Michael Thrippleton, Peter Andrews, Bridget Harris, Iain Bethune, Prashant Valluri
Macro-modeling of cerebral blood flow can help determine the impact of thermal intervention during instances of head trauma to mitigate tissue damage. This work presents a bioheat model using a 3D fluid-porous domain coupled with intersecting 1D arterial and venous vessel trees. This combined vascular porous (VaPor) model resolves both cerebral blood flow and energy equations, including heat generated by metabolism, using vasculature extracted from MRI data and is extended using a tree generation algorithm...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772244/gender-difference-in-the-effect-of-progesterone-on-neonatal-hypoxic-ischemic-brain-injury-in-mouse
#6
Shuyu Dong, Qian Zhang, Delian Kong, Chao Zhou, Jie Zhou, Jingjing Han, Yan Zhou, Guoliang Jin, Xiaodong Hua, Jun Wang, Fang Hua
This study was to investigate the effects of progesterone (PROG) on neonatal hypoxic/ischemic (NHI) brain injury, the differences in effects between genders, and the underlying mechanisms. NHI brain injury was established in both male and female neonatal mice induced by occlusion of the left common carotid artery followed by hypoxia. The mice were treated with PROG or vehicle. Fluoro-Jade B staining (F-JB), long term behavior testing, and brain magnetic resonance image (MRI) were applied to evaluate neuronal death, neurological function, and brain damage...
May 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29769612/hypothermia-broadens-the-therapeutic-time-window-of-mesenchymal-stem-cell-transplantation-for-severe-neonatal-hypoxic-ischemic-encephalopathy
#7
So Yoon Ahn, Yun Sil Chang, Dong Kyung Sung, Se In Sung, Won Soon Park
Recently, we have demonstrated that concurrent hypothermia and mesenchymal stem cells (MSCs) transplantation synergistically improved severe neonatal hypoxic ischemic encephalopathy (HIE). The current study was designed to determine whether hypothermia could extend the therapeutic time window of MSC transplantation for severe neonatal HIE. To induce HIE, newborn rat pups were exposed to 8% oxygen for 2 h following unilateral carotid artery ligation on postnatal day (P) 7. After approving severe HIE involving >50% of the ipsilateral hemisphere volume, hypothermia (32 °C) for 2 days was started...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29751744/a-case-of-raine-syndrome-presenting-with-facial-dysmorphy-and-review-of-literature
#8
Jayesh Sheth, Riddhi Bhavsar, Ajit Gandhi, Frenny Sheth, Dhairya Pancholi
BACKGROUND: Raine syndrome (RS) - an extremely rare autosomal recessive genetic disorder, is caused by a biallelic mutation in the FAM20C gene. Some of the most common clinical features include generalized osteosclerosis with a periosteal bone formation, dysmorphic face, and thoracic hypoplasia. Many cases have also been reported with oro-dental abnormalities, and developmental delay. Most of the cases result in neonatal death. However, a few non-lethal RS cases have been reported where patients survive till adulthood and exhibits a heterogeneous clinical phenotype...
May 11, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29747267/-application-of-uterine-lower-part-breakwater-like-suture-operation-in-placenta-previa
#9
Y Zhao, J W Zhu, D Wu, Q H Wang, S S Lu, X X Liu, L Zou
Objective: To explore the efficacy and safety of uterine lower posterior wall breakwater-like suture technique in controlling the intraoperative bleeding of placenta previa. Methods: From June 2016 to June 2017, 47 patients were diagnosed placenta previa in Union Hospital, Tongji Medical College of Huazhong University of Science and Technology. Posterior wall breakwater-like suture technique was used preferentially, as for cases with poor myometrium layer, lower anterior wall stitch suture was used at the same time...
April 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29746715/quantitative-susceptibility-map-analysis-in-preterm-neonates-with-germinal-matrix-intraventricular-hemorrhage
#10
Domenico Tortora, Mariasavina Severino, Jan Sedlacik, Benedetta Toselli, Mariya Malova, Alessandro Parodi, Giovanni Morana, Marco Massimo Fato, Luca Antonio Ramenghi, Andrea Rossi
BACKGROUND: Germinal matrix-intraventricular hemorrhage (GMH-IVH) is a common form of intracranial hemorrhage occurring in preterm neonates that may affect normal brain development. Although the primary lesion is easily identified on MRI by the presence of blood products, its exact extent may not be recognizable with conventional sequences. Quantitative susceptibility mapping (QSM) quantify the spatial distribution of magnetic susceptibility within biological tissues, including blood degradation products...
May 10, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29741982/one-stage-laparoscopic-assisted-anorectoplasty-for-neonates-with-anorectal-malformation-and-recto-prostatic-or-recto-bulbar-fistula-according-to-the-krickenbeck-classification
#11
Hui Xiao, Long Chen, Xiang-Hai Ren, Rui Huang, Mei Diao, Long Li
BACKGROUND: Congenital recto-urethral fistula (RUF) is the most common form of anorectal malformations (ARMs) found in boys. The aim of this study is to review our experience with one-stage laparoscopic procedure in the management of ARMs with recto-prostatic fistula and recto-bulbar fistula. METHODS: Seventeen boys with congenital RUF who underwent one-stage laparoscopy-assisted anorectoplasty (LAARP) between July 2012 and June 2015 were retrospectively in the study...
May 9, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29731237/recent-advances-in-preclinical-and-clinical-multimodal-mr-in-the-newborn-brain
#12
Vicente Enguix, Yang Ding, Gregory A Lodygensky
Aside from injury identification, MRI of the newborn brain has given us insight into cortical and white matter development, identified windows of vulnerabilities, enabled the introduction of therapeutic hypothermia which has become the standard of care in neonatal asphyxia, and is fostering leapfrogging discoveries in the field of neuro-genetics. This article reviews the main advances in recent years in newborn brain imaging both in preclinical and clinical research.
April 30, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29721918/patterns-evolution-and-severity-of-striatal-injury-in-insidious-versus-acute-onset-glutaric-aciduria-type-1
#13
Nikolas Boy, Sven F Garbade, Jana Heringer, Angelika Seitz, Stefan Kölker, Inga Harting
BACKGROUND: Striatal injury in patients with glutaric aciduria type 1 (GA1) results in a complex, predominantly dystonic, movement disorder. Onset may be acute following acute encephalopathic crisis (AEC) or insidious without apparent acute event. METHODS: We analyzed clinical and striatal magnetic resonance imaging (MRI) findings in 21 symptomatic GA1 patients to investigate if insidious- and acute-onset patients differed in timing, pattern of striatal injury, and outcome...
May 2, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29721599/optimization-of-magnetization-prepared-rapid-gradient-echo-mp-rage-sequence-for-neonatal-brain-mri
#14
Lili He, Jinghua Wang, Zhong-Lin Lu, Beth M Kline-Fath, Nehal A Parikh
BACKGROUND: Sequence optimization in neonates might improve detection sensitivity of abnormalities for a variety of conditions. However this has been historically challenging because tissue properties such as the longitudinal relaxation time and proton density differ significantly between neonates and adults. OBJECTIVE: To optimize the magnetization-prepared rapid gradient echo (MP-RAGE) sequence to enhance both signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) efficiencies...
May 2, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29712514/prenatal-diagnosis-of-suprarenal-mass-by-magnetic-resonance-imaging-a-case-series
#15
Pedro Castro, Ana Paula Matos, Heron Werner, Tatiana Fazecas, Renata Nogueira, Pedro Daltro, Edward Araujo Júnior
OBJECTIVE: The aim of this study was to evaluate the perinatal outcomes and postnatal follow-up of prenatally diagnosed suprarenal masses (SRMs) evaluated by magnetic resonance imaging (MRI). METHODS: Thirteen fetuses with SRMs detected during routine prenatal ultrasound screening were evaluated by MRI between February 2007 and May 2015. The prenatal characteristics of the masses, complications of the pregnancies, and related malformations were collected as the postnatal clinical, radiological, and pathological data...
May 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29689487/evoked-potentials-predict-psychomotor-development-in-neonates-with-normal-mri-after-hypothermia-for-hypoxic-ischemic-encephalopathy
#16
Elisa Cainelli, Daniele Trevisanuto, Francesco Cavallin, Renzo Manara, Agnese Suppiej
OBJECTIVES: To assess the prognostic role of evoked potentials (EP) in neonates with normal magnetic resonance imaging (MRI) after therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy (HIE). METHODS: Thirty-five neonates recruited for TH because of HIE, having normal neonatal MRI, performed neonatal somatosensory (SEP), visual (VEP) evoked potentials and electroencephalogram (EEG). The effect of SEP, VEP or EEG abnormalities on Griffith's developmental scales at 12 and 24 months was measured; positive (PPV) and negative (NPV) predictive value, sensitivity, specificity and accuracy were calculated...
April 16, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29684645/challenges-in-pediatric-neuroimaging
#17
REVIEW
Matthew J Barkovich, Yi Li, Rahul S Desikan, A James Barkovich, Duan Xu
Pediatric neuroimaging is challenging due the rapid structural, metabolic, and functional changes that occur in the developing brain. A specially trained team is needed to produce high quality diagnostic images in children, due to their small physical size and immaturity. Patient motion, cooperation and medical condition dictate the methods and equipment used. A customized approach tailored to each child's age and functional status with the appropriate combination of dedicated staff, imaging hardware, and software is key; these range from low-tech techniques, such as feed and swaddle, to specialized small bore MRI scanners, MRI compatible incubators and neonatal head coils...
April 20, 2018: NeuroImage
https://www.readbyqxmd.com/read/29682374/delayed-appearance-of-a-traumatic-fetal-intracranial-hemorrhage
#18
Kelly Yamasato, Nicole Kurata, Dena Towner
Background: Fetal intracranial injury is a potentially devastating sequelae of maternal trauma, but there is little guidance regarding fetal evaluation in this setting. Case: A 23-year-old woman at 27-week gestation was admitted after a high-speed motor vehicle accident. The initial obstetrical ultrasound was unremarkable, but persistently minimal fetal heart rate variability was observed. Ultrasound on day 3 after the accident showed an intracranial hyperechogenic lesion and subdural fluid collection...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29670784/ultrasound-presentation-of-a-disseminated-fetal-and-neonatal-rhabdoid-tumor
#19
Yolaine Joueidi, Aline Rousselin, Céline Rozel, Philippe Loget, Dominique Ranchere Vince, Sylvie Odent, Franck Bourdeaut, Vincent Lavoue, Maela Le Lous
This is a case report of a disseminated fetal rhabdoid tumor discovered at 32 weeks of gestation in a 29-year-old woman on immunosuppressive therapy. The mother consulted for a decrease in fetal movement. Fetal ultrasound showed signs of a disseminated tumor affecting the left armpit, liver, spleen, and limbs. A caesarian section was performed because of signs of fetal distress. Immunohistochemical analysis of a fetal biopsy showed deletion of the SMARCB1 gene. Pathological analysis of the placenta showed a rhabdoid tumor invading both fetal and maternal compartments...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29664051/predictive-value-of-cranial-ultrasound-for-neurodevelopmental-outcomes-of-very-preterm-infants-with-brain-injury
#20
Xue-Hua Zhang, Shi-Jun Qiu, Wen-Juan Chen, Xi-Rong Gao, Ya Li, Jing Cao, Jing-Jing Zhang
Background: Compared with full-term infants, very preterm infants are more vulnerable to injury and long-term disability and are at high risk of death. The predictive value of ultrasound and imaging on the neurodevelopment is one of the hot topics. This study aimed to investigate the relationship between cranial ultrasound (cUS) variables and neurodevelopmental outcomes of very preterm infants. Methods: Totally 129 very preterm infants (gestational age ≤28 weeks) in neonatal intensive care unit of Hunan Children's Hospital between January 2012 and November 2014 were included in this retrospective study...
April 20, 2018: Chinese Medical Journal
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