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https://www.readbyqxmd.com/read/28101372/lessons-i-have-learned-from-my-patients-everyday-life-with-primary-orthostatic-tremor
#1
Marie Vidailhet, Emmanuel Roze, Lucie Maugest, Cécile Gallea
BACKGROUND: Primary orthostatic tremor is a rare disorder that is still under-diagnosed or misdiagnosed. Motor symptoms are fairly characteristics but the real impact on the patient's every day life and quality of life is under-estimated. The "how my patients taught me" format describes the impact on the patients' every day life with their own words, which is rarely done. CASE PRESENTATION: A 46 year old lady was diagnosed primary orthostatic tremor (POT) based on the cardinal symptoms: feelings of instability, leg tremor and fear of falling in the standing position, improvement with walking and disappearance while sitting, frequency of Tremor in the 13-18Hz range, normal neurological examination...
2017: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/28073788/dopamine-controls-parkinson-s-tremor-by-inhibiting-the-cerebellar-thalamus
#2
Michiel F Dirkx, Hanneke E M den Ouden, Esther Aarts, Monique H M Timmer, Bastiaan R Bloem, Ivan Toni, Rick C Helmich
Parkinson's resting tremor is related to altered cerebral activity in the basal ganglia and the cerebello-thalamo-cortical circuit. Although Parkinson's disease is characterized by dopamine depletion in the basal ganglia, the dopaminergic basis of resting tremor remains unclear: dopaminergic medication reduces tremor in some patients, but many patients have a dopamine-resistant tremor. Using pharmacological functional magnetic resonance imaging, we test how a dopaminergic intervention influences the cerebral circuit involved in Parkinson's tremor...
January 9, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28072383/reconstructing-contralateral-fiber-tracts-methodological-aspects-of-cerebello-thalamocortical-pathway-reconstruction
#3
Fulvia Palesi, Jacques-Donald Tournier, F Calamante, Nils Muhlert, Gloria Castellazzi, Declan Chard, E D'Angelo, Claudia Gandini Wheeler-Kingshott
The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to thecerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (b0)...
October 2016: Functional Neurology
https://www.readbyqxmd.com/read/28062908/role-of-altered-cerebello-thalamo-cortical-network-in-the-neurobiology-of-essential-tremor
#4
Abhishek Lenka, Ketaki Swapnil Bhalsing, Rajanikant Panda, Ketan Jhunjhunwala, Rajini M Naduthota, Jitender Saini, Rose Dawn Bharath, Ravi Yadav, Pramod Kumar Pal
INTRODUCTION: Essential tremor (ET) is the most common movement disorder among adults. Although ET has been recognized as a mono-symptomatic benign illness, reports of non-motor symptoms and non-tremor motor symptoms have increased its clinical heterogeneity. The neural correlates of ET are not clearly understood. The aim of this study was to understand the neurobiology of ET using resting state fMRI. METHODS: Resting state functional MR images of 30 patients with ET and 30 age- and gender-matched healthy controls were obtained...
January 6, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28043883/trigeminal-ganglioneuroma-a-rare-cause-of-trigeminal-neuralgia-caused-by-cerebello-pontine-angle-tumor
#5
Nadeem Khan, Alex Michael, Ali Choucair, Esther Bit-Ivan
Intracranial ganglioneuromas are very rare benign tumors of neural crest origin and generally arise from peripheral nervous system or adrenal glands. Very few cases of intracranial ganglioneuroma arising from the trigeminal nerve have been reported in literature so far. Out of those reported, all have been recognized in Eastern Asia. We report a rare case of trigeminal ganglioneuroma in a 52-year-old Caucasian male presenting with right trigeminal neuralgia.
December 30, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28032321/targeting-the-cerebellum-by-noninvasive-neurostimulation-a-review
#6
REVIEW
Kim van Dun, Florian Bodranghien, Mario Manto, Peter Mariën
Transcranial magnetic and electric stimulation of the brain are novel and highly promising techniques currently employed in both research and clinical practice. Improving or rehabilitating brain functions by modulating excitability with these noninvasive tools is an exciting new area in neuroscience. Since the cerebellum is closely connected with the cerebral regions subserving motor, associative, and affective functions, the cerebello-thalamo-cortical pathways are an interesting target for these new techniques...
December 28, 2016: Cerebellum
https://www.readbyqxmd.com/read/28031220/pathological-ponto-cerebello-thalamo-cortical-activations-in-primary-orthostatic-tremor-during-lying-and-stance
#7
Florian Schöberl, Katharina Feil, Guoming Xiong, Peter Bartenstein, Christian la Fougére, Klaus Jahn, Thomas Brandt, Michael Strupp, Marianne Dieterich, Andreas Zwergal
Primary orthostatic tremor is a rare neurological disease characterized mainly by a high frequency tremor of the legs while standing. The aim of this study was to identify the common core structures of the oscillatory circuit in orthostatic tremor and how it is modulated by changes of body position. Ten patients with orthostatic tremor and 10 healthy age-matched control subjects underwent a standardized neurological and neuro-ophthalmological examination including electromyographic and posturographic recordings...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28009072/taking-the-brakes-off-the-learning-curve
#8
Freja Gheysen, Gabriel Lasne, Mélanie Pélégrini-Issac, Genevieve Albouy, Sabine Meunier, Habib Benali, Julien Doyon, Traian Popa
Motor learning is characterized by patterns of cerebello-striato-cortical activations shifting in time, yet the early dynamic and function of these activations remains unclear. Five groups of subjects underwent either continuous or intermittent theta-burst stimulation of one cerebellar hemisphere, or no stimulation just before learning a new motor sequence during fMRI scanning. We identified three phases during initial learning: one rapid, one slow, and one quasi-asymptotic performance phase. These phases were not changed by left cerebellar stimulation...
December 23, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/28003171/a-contralateral-transcondylar-fossa-approach-with-bilateral-v3-segment-exposure-for-repairing-complex-vertebral-artery-aneurysms-a-technical-case-report
#9
Nakao Ota, Rokuya Tanikawa, Masataka Miyama, Takanori Miyazaki, Yu Kinoshita, Hidetoshi Matsukawa, Fumihiro Sakakibara, Norihiro Saito, Shiro Miyata, Kosumo Noda, Toshiyuki Tsuboi, Hiroyasu Kamiyama, Sadahisa Tokuda, Kyousuke Kamada
BACKGROUND: and Importance: Microsurgical treatment for vertebral artery aneurysms can be approached through the lateral aspect of the brainstem and cerebellum. Contralateral approach may be selected in case of complex aneurysms with tortuous running, and the intracranial vertebral artery distal to the aneurysm locates in contralateral cerebello-pontine angle. When performing the aneurysm repair, exposing the V3 segment before craniotomy is advantageous. We describe the detailed surgical procedures about contralateral transcondylar fossa approach with bilateral V3 segment exposure for the repair of a complex vertebral artery aneurysm...
December 18, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27994543/repetitive-tms-on-left-cerebellum-affects-impulsivity-in-borderline-personality-disorder-a-pilot-study
#10
Giulia Zelda De Vidovich, Riccardo Muffatti, Jessica Monaco, Nicoletta Caramia, Davide Broglia, Edgardo Caverzasi, Francesco Barale, Egidio D'Angelo
The borderline personality disorder (BPD) is characterized by a severe pattern of instability in emotional regulation, interpersonal relationships, identity and impulse control. These functions are related to the prefrontal cortex (PFC), and since PFC shows a rich anatomical connectivity with the cerebellum, the functionality of the cerebellar-PFC axis may impact on BPD. In this study, we investigated the potential involvement of cerebello-thalamo-cortical connections in impulsive reactions through a pre/post stimulation design...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27904421/cannabis-induced-moto-cognitive-dysfunction-in-wistar-rats-ameliorative-efficacy-of-nigella-sativa
#11
Aminu Imam, Moyosore Saliu Ajao, Abdulbasit Amin, Wahab Imam Abdulmajeed, Abdulmumin Ibrahim, Olayemi Joseph Olajide, Musa Iyiola Ajibola, Abdulmusawir Alli-Oluwafuyi, Wasiu Gbolahan Balogun
BACKGROUND: Cannabis is a widely used illicit drug with various threats of personality syndrome, and Nigella sativa has been widely implicated as having therapeutic efficacy in many neurological diseases. The present study investigates the ameliorative efficacy of Nigella sativa oil (NSO) on cannabis-induced moto-cognitive defects. METHODS: Scopolamine (1 mg/kg i.p.) was given to induce dementia as a standard base line for cannabis (20 mg/kg)-induced cognitive impairment, followed by an oral administration of NSO (1 ml/kg) for 14 consecutive days...
September 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27853938/differential-pattern-of-cerebellar-atrophy-in-tremor-predominant-and-akinetic-rigidity-predominant-parkinson-s-disease
#12
Camila Callegari Piccinin, Lidiane Soares Campos, Rachel Paes Guimarães, Luiza Gonzaga Piovesana, Maria Cristina Arci Dos Santos, Paula Christina Azevedo, Brunno Machado Campos, Thiago Junqueira Ribeiro de Rezende, Augusto Amato-Filho, Fernando Cendes, Anelyssa D'Abreu
Parkinson's disease (PD) is an akinetic-rigid disorder characterized by basal ganglia dysfunction and a possible cerebello-thalamo-cortical circuit involvement. This study aims to investigate the pattern of cerebellar involvement in PD and to assess whether it correlates with clinical parameters. MRI scans were acquired from 50 healthy controls (HC) and 63 patients; 44 were classified as tremor-predominant-PD (PDT) and 19 as akinetic/rigidity-predominant-PD (PDAR). We designed an analysis of covariance including the three groups and contrasted as follows: (1) all 63 PD vs HC, (2) PDT vs HC, (3) PDAR vs HC, and (4) PDT vs PDAR...
November 16, 2016: Cerebellum
https://www.readbyqxmd.com/read/27815592/-intraoperative-monitoring-of-cochlear-nerve-function-during-cerebello-pontine-angle-surgery
#13
S Rampp, T Rahne, S K Plontke, C Strauss, J Prell
BACKGROUND: Surgical procedures in the cerebello-pontine angle (CPA), e. g. for vestibular schwannoma, have an increased risk for damage to the cochlear nerve. Consequently, hearing deterioration up to complete deafness may result with severe impact on quality of life. Methods for intraoperative monitoring of function may minimize such risks. OBJECTIVE: Review of current methods for intraoperative monitoring of the cochelar nerve and summary of new developments...
November 4, 2016: HNO
https://www.readbyqxmd.com/read/27785688/dti-fiber-tractography-of-cerebro-cerebellar-pathways-and-clinical-evaluation-of-ataxia-in-childhood-posterior-fossa-tumor-survivors
#14
Myung Eun Oh, Pablo Hernáiz Driever, Rajiv K Khajuria, Stefan Mark Rueckriegel, Elisabeth Koustenis, Harald Bruhn, Ulrich-Wilhelm Thomale
Pediatric posterior fossa (PF) tumor survivors experience long-term motor deficits. Specific cerebrocerebellar connections may be involved in incidence and severity of motor dysfunction. We examined the relationship between long-term ataxia as well as fine motor function and alteration of differential cerebellar efferent and afferent pathways using diffusion tensor imaging (DTI) and tractography. DTI-based tractography was performed in 19 patients (10 pilocytic astrocytoma (PA) and 9 medulloblastoma patients (MB)) and 20 healthy peers...
October 26, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27774574/constrained-spherical-deconvolution-tractography-reveals-cerebello-mammillary-connections-in-humans
#15
Alberto Cacciola, Demetrio Milardi, Alessandro Calamuneri, Lilla Bonanno, Silvia Marino, Pietro Ciolli, Margherita Russo, Daniele Bruschetta, Antonio Duca, Fabio Trimarchi, Angelo Quartarone, Giuseppe Anastasi
According to the classical view, the cerebellum has long been confined to motor control physiology; however, it has now become evident that it exerts several non-somatic features other than the coordination of movement and is engaged also in the regulation of cognition and emotion. In a previous diffusion-weighted imaging-constrained spherical deconvolution (CSD) tractography study, we demonstrated the existence of a direct cerebellum-hippocampal pathway, thus reinforcing the hypothesis of the cerebellar role in non-motor domains...
October 24, 2016: Cerebellum
https://www.readbyqxmd.com/read/27733542/asynchronous-development-of-cerebellar-cerebello-cortical-and-cortico-cortical-functional-networks-in-infancy-childhood-and-adulthood
#16
Judy A Kipping, Ta Ahn Tuan, Marielle V Fortier, Anqi Qiu
Evidence from clinical studies shows that early cerebellar injury can cause abnormal development of the cerebral cortex in children. Characterization of normative development of the cerebellar and cerebello-cortical organization in early life is of great clinical importance. Here, we analyzed cerebellar, cerebello-cortical, and cortico-cortical functional networks using resting-state functional magnetic resonance imaging data of healthy infants (6 months, n = 21), children (4-10 years, n = 68), and adults (23-38 years, n = 25)...
October 12, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27579172/the-in-vivo-reduction-of-afferent-facilitation-induced-by-low-frequency-electrical-stimulation-of-the-motor-cortex-is-antagonized-by-cathodal-direct-current-stimulation-of-the-cerebellum
#17
Nordeyn Oulad Ben Taib, Mario Manto
BACKGROUND: Low-frequency electrical stimulation to the motor cortex (LFSMC) depresses the excitability of motor circuits by long-term depression (LTD)-like effects. The interactions between LFSMC and cathodal direct current stimulation (cDCS) over the cerebellum are unknown. METHODS: We assessed the corticomotor responses and the afferent facilitation of corticomotor responses during a conditioning paradigm in anaesthetized rats. We applied LFSMC at a frequency of 1 Hz and a combination of LFSMC with cDCS...
2016: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/27573027/cerebello-cerebral-connectivity-in-the-developing-brain
#18
Kay Pieterman, Dafnis Batalle, Jeroen Dudink, J-Donald Tournier, Emer J Hughes, Madeleine Barnett, Manon J Benders, A David Edwards, Freek E Hoebeek, Serena J Counsell
Disrupted cerebellar development and injury is associated with impairments in both motor and non-motor domains. Methods to non-invasively characterize cerebellar afferent and efferent connections during early development are lacking. The aim of this study was to assess the feasibility of delineating cortico-ponto-cerebellar (CPC) and cerebello-thalamo-cortical (CTC) white matter tracts during brain development using high angular resolution diffusion imaging (HARDI). HARDI data were obtained in 24 infants born between 24(+6) and 39 weeks gestational age (median 33(+4) weeks) and scanned between 29(+1) and 44 weeks postmenstrual age (PMA) (median 37(+1) weeks)...
August 29, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27566262/tell-me-twice-a-multi-study-analysis-of-the-functional-connectivity-between-the-cerebrum-and-cerebellum-after-repeated-trait-information
#19
Frank Van Overwalle, Elien Heleven, Ning Ma, Peter Mariën
This multi-study analysis (6 fMRI studies; 142 participants) explores the functional activation and connectivity of the cerebellum with the cerebrum during repeated behavioral information uptake informing about personality traits of different persons. The results suggest that trait repetition recruits activity in areas belonging to the mentalizing and executive control networks in the cerebrum, and the executive control areas in the cerebellum. Cerebral activation was observed in the executive control network including the posterior medial frontal cortex (pmFC), the bilateral prefrontal cortex (PFC) and bilateral inferior parietal cortex (IPC), in the mentalizing network including the bilateral middle temporal cortex (MTC) extending to the right superior temporal cortex (STC), as well as in the visual network including the left cuneus (Cun) and the left inferior occipital cortex...
January 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/27561441/current-concepts-of-essential-tremor
#20
F Gövert, J S Becktepe, G Deuschl
Essential tremor is clinically defined but there is increasing evidence that it is not a unique entity. Its pathophysiology has been studied with many methods but may also vary between subtypes. Neurophysiologically, there is strong evidence that a specific cerebello-thalamo-cortical loop is abnormally oscillating. The cause of its uncontrolled oscillation is not yet understood. The clear proof of a degenerative cause is still lacking and abnormal receptors or other causes of altered non-progressive functional disturbance cannot be excluded...
August 2016: Revue Neurologique
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