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https://www.readbyqxmd.com/read/28316589/a-postural-tremor-highly-responsive-to-transcranial-cerebello-cerebral-dcs-in-arca3
#1
Florian Bodranghien, Nordeyn Oulad Ben Taib, Lionel Van Maldergem, Mario Manto
BACKGROUND AND OBJECTIVES: Cerebellar ataxias are disabling disorders that impact the quality of life of patients. In many cases, an effective treatment is missing. Despite the increasing knowledge on the pathogenesis of cerebellar disorders including genetic aspects, there is currently a gap in the therapeutical management of cerebellar deficits. Cerebellar ataxia associated with ANO10 mutation (ARCA3) presents a disabling cerebellar syndrome. The aim of this study is to report a patient with a marked postural tremor responding to transcranial cerebello-cerebral direct current stimulation (tCCDCS)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28229379/a-novel-frameshift-mutation-in-the-sterol-27-hydroxylase-gene-in-an-egyptian-family-with-cerebrotendinous-xanthomatosis-without-cataract
#2
Mohamed S Abdel-Hamid, Mahmoud Y Issa, Ghada A Otaify, Maha S Zaki
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid storage disorder caused by deficiency of the mitochondrial cytochrome P450 sterol 27-hydroxylase enzyme encoded by CYP27A1 gene. CTX is characterized by tendon xanthomas, juvenile cataracts and multiple progressive neurological symptoms. Here we report on the clinical and molecular findings of a 35-years old Egyptian patient with CTX without cataract. Parents were first cousins with family history of two deceased sibs with mild impaired cognitive functions and epilepsy without appearance of tendon xanthomas...
April 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28208975/solid-cystic-hypoglossal-nerve-schwannoma-with-fluid-fluid-level-a-rare-case-report
#3
Kulamani Sahoo, Pramod Ramchand Shaha, Rahul Khetawat, Mohd Abbas Ilyas, Gaurav Rajendra Khairnar
Schwannomas (neurinoma, neurilemmoma) are benign slow-growing encapsulated tumours originating from well-differentiated myelin-producing Schwann cells or nerve fiber sheet cells at the glial-Schwann cell junction. Hypoglossal nerve schwannoma mostly develops in the intracranial and extra-cranial segment or in both intracranial and extra-cranial segment forming a dumbbell shape tumour. The peripheral hypoglossal schwannomas are very rare. We present a case of right hypoglossal nerve schwannoma in a 46-year-old female who presented with headache and neck pain since 2 weeks with deviation of tongue to right side since 1 week...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28194095/altered-hippocampo-cerebello-cortical-circuit-in-schizophrenia-by-a-spatiotemporal-consistency-and-causal-connectivity-analysis
#4
Xi Chen, Yuchao Jiang, Lin Chen, Hui He, Li Dong, Changyue Hou, Mingjun Duan, Mi Yang, Dezhong Yao, Cheng Luo
In the current study, FOur-dimensional Consistency of local neural Activities (FOCA) analysis was used to investigate the local consistency by integrating the temporal and spatial information of the local region. In the current study, resting-state fMRI data of 69 schizophrenia patients and 70 healthy controls were collected. FOCA was utilized to investigate the local consistency. Moreover, Granger causal analysis was used to investigate causal functional connectivity among these areas, which exhibited significantly different local consistency between groups...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28127519/increased-thalamic-centrality-and-putamen-thalamic-connectivity-in-patients-with-parkinsonian-resting-tremor
#5
Quanquan Gu, Hengyi Cao, Min Xuan, Wei Luo, Xiaojun Guan, Jingjing Xu, Peiyu Huang, Minming Zhang, Xiaojun Xu
INTRODUCTION: Evidence has indicated a strong association between hyperactivity in the cerebello-thalamo-motor cortical loop and resting tremor in Parkinson's disease (PD). Within this loop, the thalamus serves as a central hub based on its structural centrality in the generation of resting tremor. To study whether this thalamic abnormality leads to an alteration at the whole-brain level, our study investigated the role of the thalamus in patients with parkinsonian resting tremor in a large-scale brain network context...
January 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28101372/lessons-i-have-learned-from-my-patients-everyday-life-with-primary-orthostatic-tremor
#6
Marie Vidailhet, Emmanuel Roze, Lucie Maugest, Cécile Gallea
BACKGROUND: Primary orthostatic tremor is a rare disorder that is still under-diagnosed or misdiagnosed. Motor symptoms are fairly characteristics but the real impact on the patient's every day life and quality of life is under-estimated. The "how my patients taught me" format describes the impact on the patients' every day life with their own words, which is rarely done. CASE PRESENTATION: A 46 year old lady was diagnosed primary orthostatic tremor (POT) based on the cardinal symptoms: feelings of instability, leg tremor and fear of falling in the standing position, improvement with walking and disappearance while sitting, frequency of Tremor in the 13-18Hz range, normal neurological examination...
2017: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/28073788/dopamine-controls-parkinson-s-tremor-by-inhibiting-the-cerebellar-thalamus
#7
Michiel F Dirkx, Hanneke E M den Ouden, Esther Aarts, Monique H M Timmer, Bastiaan R Bloem, Ivan Toni, Rick C Helmich
Parkinson's resting tremor is related to altered cerebral activity in the basal ganglia and the cerebello-thalamo-cortical circuit. Although Parkinson's disease is characterized by dopamine depletion in the basal ganglia, the dopaminergic basis of resting tremor remains unclear: dopaminergic medication reduces tremor in some patients, but many patients have a dopamine-resistant tremor. Using pharmacological functional magnetic resonance imaging, we test how a dopaminergic intervention influences the cerebral circuit involved in Parkinson's tremor...
January 9, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28072383/reconstructing-contralateral-fiber-tracts-methodological-aspects-of-cerebello-thalamocortical-pathway-reconstruction
#8
Fulvia Palesi, Jacques-Donald Tournier, F Calamante, Nils Muhlert, Gloria Castellazzi, Declan Chard, E D'Angelo, Claudia Gandini Wheeler-Kingshott
The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to thecerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (b0)...
October 2016: Functional Neurology
https://www.readbyqxmd.com/read/28062908/role-of-altered-cerebello-thalamo-cortical-network-in-the-neurobiology-of-essential-tremor
#9
Abhishek Lenka, Ketaki Swapnil Bhalsing, Rajanikant Panda, Ketan Jhunjhunwala, Rajini M Naduthota, Jitender Saini, Rose Dawn Bharath, Ravi Yadav, Pramod Kumar Pal
INTRODUCTION: Essential tremor (ET) is the most common movement disorder among adults. Although ET has been recognized as a mono-symptomatic benign illness, reports of non-motor symptoms and non-tremor motor symptoms have increased its clinical heterogeneity. The neural correlates of ET are not clearly understood. The aim of this study was to understand the neurobiology of ET using resting state fMRI. METHODS: Resting state functional MR images of 30 patients with ET and 30 age- and gender-matched healthy controls were obtained...
January 6, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28043883/trigeminal-ganglioneuroma-a-rare-case-of-trigeminal-neuralgia-caused-by-cerebellopontine-angle-tumor
#10
Nadeem Khan, Alex Michael, Ali Choucair, Esther Bit-Ivan
BACKGROUND: Intracranial ganglioneuromas are very rare benign tumors of neural crest origin and generally arise from the peripheral nervous system or adrenal glands. Very few cases of intracranial ganglioneuroma arising from the trigeminal nerve have been reported in the literature, all in East Asia. CASE DESCRIPTION: A 52-year-old male presented to his primary care physician for evaluation of right facial and periorbital pain for over 18 months. He also reported a two-week history of diplopia with right lateral gaze, which resolved spontaneously...
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28032321/targeting-the-cerebellum-by-noninvasive-neurostimulation-a-review
#11
REVIEW
Kim van Dun, Florian Bodranghien, Mario Manto, Peter Mariën
Transcranial magnetic and electric stimulation of the brain are novel and highly promising techniques currently employed in both research and clinical practice. Improving or rehabilitating brain functions by modulating excitability with these noninvasive tools is an exciting new area in neuroscience. Since the cerebellum is closely connected with the cerebral regions subserving motor, associative, and affective functions, the cerebello-thalamo-cortical pathways are an interesting target for these new techniques...
December 28, 2016: Cerebellum
https://www.readbyqxmd.com/read/28031220/pathological-ponto-cerebello-thalamo-cortical-activations-in-primary-orthostatic-tremor-during-lying-and-stance
#12
Florian Schöberl, Katharina Feil, Guoming Xiong, Peter Bartenstein, Christian la Fougére, Klaus Jahn, Thomas Brandt, Michael Strupp, Marianne Dieterich, Andreas Zwergal
Primary orthostatic tremor is a rare neurological disease characterized mainly by a high frequency tremor of the legs while standing. The aim of this study was to identify the common core structures of the oscillatory circuit in orthostatic tremor and how it is modulated by changes of body position. Ten patients with orthostatic tremor and 10 healthy age-matched control subjects underwent a standardized neurological and neuro-ophthalmological examination including electromyographic and posturographic recordings...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28009072/taking-the-brakes-off-the-learning-curve
#13
Freja Gheysen, Gabriel Lasne, Mélanie Pélégrini-Issac, Genevieve Albouy, Sabine Meunier, Habib Benali, Julien Doyon, Traian Popa
Motor learning is characterized by patterns of cerebello-striato-cortical activations shifting in time, yet the early dynamic and function of these activations remains unclear. Five groups of subjects underwent either continuous or intermittent theta-burst stimulation of one cerebellar hemisphere, or no stimulation just before learning a new motor sequence during fMRI scanning. We identified three phases during initial learning: one rapid, one slow, and one quasi-asymptotic performance phase. These phases were not changed by left cerebellar stimulation...
December 23, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/28003171/a-contralateral-transcondylar-fossa-approach-with-bilateral-v3-segment-exposure-for-repairing-complex-vertebral-artery-aneurysms
#14
Nakao Ota, Rokuya Tanikawa, Masataka Miyama, Takanori Miyazaki, Yu Kinoshita, Hidetoshi Matsukawa, Fumihiro Sakakibara, Norihiro Saito, Shiro Miyata, Kosumo Noda, Toshiyuki Tsuboi, Hiroyasu Kamiyama, Sadahisa Tokuda, Kyousuke Kamada
BACKGROUND AND IMPORTANCE: Microsurgical treatment for vertebral artery aneurysms can be approached through the lateral aspect of the brainstem and cerebellum. A contralateral approach may be selected in complex aneurysms with tortuous running and the intracranial vertebral artery distal to the aneurysm located in the contralateral cerebellopontine angle. When repairing the aneurysm, exposing the V3 segment before craniotomy is advantageous. We describe the detailed surgical procedures of the contralateral transcondylar fossa approach with bilateral V3 segment exposure for the repair of a complex vertebral artery aneurysm...
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27994543/repetitive-tms-on-left-cerebellum-affects-impulsivity-in-borderline-personality-disorder-a-pilot-study
#15
Giulia Zelda De Vidovich, Riccardo Muffatti, Jessica Monaco, Nicoletta Caramia, Davide Broglia, Edgardo Caverzasi, Francesco Barale, Egidio D'Angelo
The borderline personality disorder (BPD) is characterized by a severe pattern of instability in emotional regulation, interpersonal relationships, identity and impulse control. These functions are related to the prefrontal cortex (PFC), and since PFC shows a rich anatomical connectivity with the cerebellum, the functionality of the cerebellar-PFC axis may impact on BPD. In this study, we investigated the potential involvement of cerebello-thalamo-cortical connections in impulsive reactions through a pre/post stimulation design...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27904421/cannabis-induced-moto-cognitive-dysfunction-in-wistar-rats-ameliorative-efficacy-of-nigella-sativa
#16
Aminu Imam, Moyosore Saliu Ajao, Abdulbasit Amin, Wahab Imam Abdulmajeed, Abdulmumin Ibrahim, Olayemi Joseph Olajide, Musa Iyiola Ajibola, Abdulmusawir Alli-Oluwafuyi, Wasiu Gbolahan Balogun
BACKGROUND: Cannabis is a widely used illicit drug with various threats of personality syndrome, and Nigella sativa has been widely implicated as having therapeutic efficacy in many neurological diseases. The present study investigates the ameliorative efficacy of Nigella sativa oil (NSO) on cannabis-induced moto-cognitive defects. METHODS: Scopolamine (1 mg/kg i.p.) was given to induce dementia as a standard base line for cannabis (20 mg/kg)-induced cognitive impairment, followed by an oral administration of NSO (1 ml/kg) for 14 consecutive days...
September 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27853938/differential-pattern-of-cerebellar-atrophy-in-tremor-predominant-and-akinetic-rigidity-predominant-parkinson-s-disease
#17
Camila Callegari Piccinin, Lidiane Soares Campos, Rachel Paes Guimarães, Luiza Gonzaga Piovesana, Maria Cristina Arci Dos Santos, Paula Christina Azevedo, Brunno Machado Campos, Thiago Junqueira Ribeiro de Rezende, Augusto Amato-Filho, Fernando Cendes, Anelyssa D'Abreu
Parkinson's disease (PD) is an akinetic-rigid disorder characterized by basal ganglia dysfunction and a possible cerebello-thalamo-cortical circuit involvement. This study aims to investigate the pattern of cerebellar involvement in PD and to assess whether it correlates with clinical parameters. MRI scans were acquired from 50 healthy controls (HC) and 63 patients; 44 were classified as tremor-predominant-PD (PDT) and 19 as akinetic/rigidity-predominant-PD (PDAR). We designed an analysis of covariance including the three groups and contrasted as follows: (1) all 63 PD vs HC, (2) PDT vs HC, (3) PDAR vs HC, and (4) PDT vs PDAR...
November 16, 2016: Cerebellum
https://www.readbyqxmd.com/read/27815592/-intraoperative-monitoring-of-cochlear-nerve-function-during-cerebello-pontine-angle-surgery
#18
S Rampp, T Rahne, S K Plontke, C Strauss, J Prell
BACKGROUND: Surgical procedures in the cerebello-pontine angle (CPA), e. g. for vestibular schwannoma, have an increased risk for damage to the cochlear nerve. Consequently, hearing deterioration up to complete deafness may result with severe impact on quality of life. Methods for intraoperative monitoring of function may minimize such risks. OBJECTIVE: Review of current methods for intraoperative monitoring of the cochelar nerve and summary of new developments...
November 4, 2016: HNO
https://www.readbyqxmd.com/read/27785688/dti-fiber-tractography-of-cerebro-cerebellar-pathways-and-clinical-evaluation-of-ataxia-in-childhood-posterior-fossa-tumor-survivors
#19
Myung Eun Oh, Pablo Hernáiz Driever, Rajiv K Khajuria, Stefan Mark Rueckriegel, Elisabeth Koustenis, Harald Bruhn, Ulrich-Wilhelm Thomale
Pediatric posterior fossa (PF) tumor survivors experience long-term motor deficits. Specific cerebrocerebellar connections may be involved in incidence and severity of motor dysfunction. We examined the relationship between long-term ataxia as well as fine motor function and alteration of differential cerebellar efferent and afferent pathways using diffusion tensor imaging (DTI) and tractography. DTI-based tractography was performed in 19 patients (10 pilocytic astrocytoma (PA) and 9 medulloblastoma patients (MB)) and 20 healthy peers...
October 26, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27774574/constrained-spherical-deconvolution-tractography-reveals-cerebello-mammillary-connections-in-humans
#20
Alberto Cacciola, Demetrio Milardi, Alessandro Calamuneri, Lilla Bonanno, Silvia Marino, Pietro Ciolli, Margherita Russo, Daniele Bruschetta, Antonio Duca, Fabio Trimarchi, Angelo Quartarone, Giuseppe Anastasi
According to the classical view, the cerebellum has long been confined to motor control physiology; however, it has now become evident that it exerts several non-somatic features other than the coordination of movement and is engaged also in the regulation of cognition and emotion. In a previous diffusion-weighted imaging-constrained spherical deconvolution (CSD) tractography study, we demonstrated the existence of a direct cerebellum-hippocampal pathway, thus reinforcing the hypothesis of the cerebellar role in non-motor domains...
April 2017: Cerebellum
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