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https://www.readbyqxmd.com/read/29147599/prevalence-of-dog-erythrocyte-antigen-1-in-7-414-dogs-in-italy
#1
Anyela Andrea Medina Valentin, Alessandra Gavazza, George Lubas
The study aim was to establish the prevalence of DEA 1, the most immunogenic and clinically important blood group in canine blood transfusion, in 7,414 dogs from Italy. The potential sensitization risk following a first transfusion and the acute reaction risk following a second transfusion given without a cross-matching and blood typing test were also calculated. Dogs tested were purebred (4,798) and mongrel (2,616); 38.8% were DEA 1 negative and 61.2% were DEA 1 positive. High prevalence for DEA 1 positive blood type was found in Ariegeois and English Setter, whereas German Shepherd and Boxer had higher DEA 1 negative blood type...
2017: Veterinary Medicine International
https://www.readbyqxmd.com/read/29138844/the-%C3%A2-%C3%AE-3-7-deletion-in-%C3%AE-%C3%A2-globin-genes-increases-the-concentration-of-fetal-hemoglobin-and-hemoglobin-a2-in-a-saudi-arabian-population
#2
J Francis Borgio, Sayed Abdulazeez, Noor B Almandil, Zaki A Naserullah, Sana Al-Jarrash, Ahmed M Al-Suliman, Huda Ismail Elfakharay, Fuad S Qaw, Fatimah I Alabdrabalnabi, Mohammed A Alkhalifah, Mohammed Shakil Akhtar, Hatem Qutub, Amein K Al-Ali
The regions of Al‑Qatif and Al‑Ahssa in the Eastern Province of Saudi Arabia are known for their high prevalence of hemoglobinopathies, including β‑thalassemia and sickle cell anemia. Previously, the α‑gene deletion has been demonstrated as highly prevalent among populations residing in these two regions. The present study was conducted in order to investigate the implications of the α‑globin gene deletion on fetal hemoglobin (HbF) and hemoglobin α2 (HbA2) concentrations in patients with transfusion‑dependent β‑thalassemia...
November 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29135009/bacterial-species-identifiable-magnetic-nanosystems-for-early-sepsis-diagnosis-and-extracorporeal-photodynamic-blood-disinfection
#3
Jianhao Wang, Hao Wu, Yanmei Yang, Rong Yan, Yuan Zhao, Yanhao Wang, Aihong Chen, Shilong Shao, Pengju Jiang, Yong-Qiang Li
Despite the numerous bacteria detection and elimination techniques available nowadays, sensitive diagnosis and treatment of sepsis (caused by the presence of bacteria in the bloodstream), especially at the early stage, remain big challenges. Here we report a nanosystem for early sepsis diagnosis and complete extracorporeal blood disinfection, based on iron oxide magnetic nanoparticles functionalized with chlorin e6 molecules and bacterial species-identifiable aptamers (Fe3O4-Ce6-Apt). We demonstrate that the Fe3O4-Ce6-Apt nanosystem can achieve simultaneous blood bacterial species identification and enrichment in a single step, and the enriched bacteria can be easily detected with the assistance of fluorescence microscopic determination...
November 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/29129410/iron-metabolism-and-the-role-of-the-iron-regulating-hormone-hepcidin-in-health-and-disease
#4
Raed Daher, Hana Manceau, Zoubida Karim
Although iron is vital, its free form is likely to be involved in oxidation-reduction reactions, leading to the formation of free radicals and oxidative stress. Living organisms have developed protein systems to transport free iron through the cell membranes and biological fluids and store it in a non-toxic and readily mobilizable form to avoid iron toxicity. Hepcidin plays a crucial role in maintaining iron homeostasis. Hepcidin expression is directly regulated by variations in iron intake and its repression leads to an increase in bioavailable serum iron level...
November 9, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29124766/direct-costs-of-transfusion-reactions-an-expert-judgement-approach
#5
M P Janssen, A J W van Tilborgh, K M K de Vooght, A G Bokhorst, J C Wiersum-Osselton
BACKGROUND AND OBJECTIVES: Despite increasingly meticulous haemovigilance reporting throughout the world, a systematic assessment of the cost of transfusion reactions is still lacking. This is partly caused by the fact that such an assessment requires a subjective expert assessment of the additional costs linked to the adverse reaction. Data on the cost of transfusion reactions could support decision-making regarding blood transfusion safety measures. MATERIALS AND METHODS: Thirteen experts from nine hospitals were asked to estimate the additional care required following various types of transfusion reactions...
November 9, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29119573/temperature-cycling-during-platelet-cold-storage-improves-in-vivo-recovery-and-survival-in-healthy-volunteers
#6
Jaroslav G Vostal, Monique P Gelderman, Andrey Skripchenko, Fei Xu, Ying Li, Johannah Ryan, Chunrong Cheng, Pam Whitley, Michael Wellington, Sherrie Sawyer, Shalene Hanley, Stephen J Wagner
BACKGROUND: Room temperature (RT) storage of platelets (PLTs) can support bacterial proliferation in contaminated units, which can lead to transfusion-transmitted septic reactions. Cold temperature storage of PLTs could reduce bacterial proliferation but cold exposure produces activation-like changes in PLTs and leads to their rapid clearance from circulation. Cold-induced changes are reversible by warming and periodic rewarming during cold storage (temperature cycling [TC]) has been proposed to alleviate cold-induced reduction in PLT circulation...
November 8, 2017: Transfusion
https://www.readbyqxmd.com/read/29108091/effects-of-low-dose-epinephrine-on-perioperative-hemostasis-and-inflammatory-reaction-in-major-surgeries-a%C3%A2-randomized%C3%A2-clinical-trial
#7
J L Liu, W N Zeng, F Y Wang, C Chen, X Y Gong, H Yang, Z J Tan, X L Jia, L Yang
BACKGROUND: Haemostasis, thrombosis, and surgical stress-induced immune reaction are important for perioperative morbidity and recovery in major surgeries. OBJECTIVES: This study aimed to evaluate the effects of combined administration of low-dose epinephrine (LDEPI) plus tranexamic acid (TXA) on perioperative blood loss, thromboembolic complications, and inflammatory response in total hip arthroplasty (THA). PATIENTS /METHODS: Patients scheduled for THA (n = 195) were randomized into 3 interventions: intravenous (IV) LDEPI plus TXA (Group IV); topical (TP) diluted-epinephrine plus TXA (Group TP); and TXA alone as control (CT) (Group CT)...
November 6, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29107157/efficacy-reliability-and-safety-of-completely-autologous-fibrin-glue-in-neurosurgical-procedures-single-center-retrospective-large-number-case-study
#8
Noriyuki Nakayama, Hirohito Yano, Yusuke Egashira, Yukiko Enomoto, Naoyuki Ohe, Nobuhiro Kanemura, Junichi Kitagawa, Toru Iwama
OBJECTIVE: Commercially available fibrin glue (Com-FG) used commonly worldwide is produced with pooled human plasma from multiple donors and is added bovine aprotinin, however, which involves the risk of infection, allogenic immunity, and allergic reactions. We evaluate the efficacy, reliability, and safety of completely autologous fibrin glue (CAFG). METHODS: From August 2014 to February 2016, prospective data were collected and analyzed from 153 patients. CAFG was prepared with the CRYOSEAL(®) System using autologous blood and applied during neurosurgical procedures...
October 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29102975/fatal-delayed-haemolytic-transfusion-reaction-in-a-patient-without-previous-transfusions-but-with-an-obstetric-history-of-13-pregnancies
#9
Evgeni Chubar, Naiel Bisharat
Delayed haemolytic transfusion reaction is a rare, life-threatening complication of blood transfusion that has been typically described among patients with sickle cell disease (SCD) due to alloimmunisation induced by their exposure to red blood cell antigens through recurrent transfusions. We report the case of a patient who suffered from fatal delayed haemolytic transfusion reaction (DHTR) occurring 1 week after blood transfusion. Indirect antiglobulin testing confirmed the presence of anti-Kell antibodies that were absent in the pretransfusion sample...
November 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29102834/establishment-of-an-alternative-efficiently-genotyping-strategy-for-human-abo-gene
#10
Enzhu Jiang, Peifu Yu, Siyi Zhang, Chunmei Li, Mei Ding, Baojie Wang, Hao Pang
ABO genotyping is used in several disciplines, including transfusion, transplantation, human evolution, and forensic medicine. Detection of single nucleotide polymorphisms (SNPs) on a locus is a common way to identify different genotypes. In this study we developed a strategy for ABO genotyping, which can rapidly and efficiently detect SNPs. DNA fragments containing 4 SNPs in the ABO gene (c.261delG, c.297A > G, c.1009A > G, and c.1061delC) were amplified using individually and multiplexed polymerase chain reaction (PCR)-based methods and subsequently genotyped by high-resolution melting (HRM) analysis...
November 1, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29094483/impact-of-intraoperative-blood-salvage-on-monocyte-subsets-alteration-and-intracellular-tnf-%C3%AE-production
#11
Hagen Bomberg, Thomas Volk, Andreas Biedler, Sven O Schneider
Intraoperative salvaged blood is used to reduce allogeneic blood transfusion in orthopedic surgery patients. However, salvaged blood reinfusion may lead to immune reactions. Salvaged and venous blood from 20 patients undergoing hip arthroplasty was processed. The salvaged samples were mixed with patients' venous blood and incubated in absence or presence of lipopolysaccharide. SAMPLES: Venous: venous patient blood (n=20). Native: mixed salvaged native blood (n=20). Filtered: mixed salvaged leukocyte filtered blood (n=20)...
November 1, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29090247/perioperative-red-blood-cell-transfusion-in-orofacial-surgery
#12
REVIEW
So-Young Park, Kwang-Suk Seo, Myong-Hwan Karm
In the field of orofacial surgery, a red blood cell transfusion (RBCT) is occasionally required during double jaw and oral cancer surgery. However, the question remains whether the effect of RBCT during the perioperative period is beneficial or harmful. The answer to this question remains challenging. In the field of orofacial surgery, transfusion is performed for the purpose of oxygen transfer to hypoxic tissues and plasma volume expansion when there is bleeding. However, there are various risks, such as infectious complications (viral and bacterial), transfusion-related acute lung injury, ABO and non-ABO associated hemolytic transfusion reactions, febrile non-hemolytic transfusion reactions, transfusion associated graft-versus-host disease, transfusion associated circulatory overload, and hypersensitivity transfusion reaction including anaphylaxis and transfusion-related immune-modulation...
September 2017: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/29090212/metabolism-of-citrate-and-other-carboxylic-acids-in-erythrocytes-as-a-function-of-oxygen-saturation-and-refrigerated-storage
#13
Travis Nemkov, Kaiqi Sun, Julie A Reisz, Tatsuro Yoshida, Andrew Dunham, Edward Y Wen, Alexander Q Wen, Rob C Roach, Kirk C Hansen, Yang Xia, Angelo D'Alessandro
State-of-the-art proteomics technologies have recently helped to elucidate the unanticipated complexity of red blood cell metabolism. One recent example is citrate metabolism, which is catalyzed by cytosolic isoforms of Krebs cycle enzymes that are present and active in mature erythrocytes and was determined using quantitative metabolic flux analysis. In previous studies, we reported significant increases in glycolytic fluxes in red blood cells exposed to hypoxia in vitro or in vivo, an observation relevant to transfusion medicine owing to the potential benefits associated with hypoxic storage of packed red blood cells...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29089726/the-use-of-idarucizumab-for-dabigatran-reversal-in-clinical-practice-a-case-series
#14
Pavel Goriacko, Vicken Yaghdjian, Issam Koleilat, Mark Sinnett, Harshal Shukla
PURPOSE: To describe the use of idarucizumab (Praxbind, Boehringer Ingelheim) in routine clinical practice at a large urban academic medical center. SUMMARY: Seven total doses of idarucizumab were administered to six unique patients from October 31, 2015, to October 31, 2016. The reversal agent was used in conjunction with local bleeding control measures, blood product transfusions, and acid-suppressive therapy. In 86% of cases, idarucizumab administration resulted in a successful cessation of bleeding by clinical assessment...
November 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29079593/hypoxia-modulates-the-purine-salvage-pathway-and-decreases-red-blood-cell-and-supernatant-levels-of-hypoxanthine-during-refrigerated-storage
#15
Travis Nemkov, Kaiqi Sun, Julie A Reisz, Anren Song, Tatsuro Yoshida, Andrew Dunham, Matthew J Wither, Richard O Francis, Robert C Roach, Monika Dzieciatkowska, Stephen C Rogers, Allan Doctor, Anastasios Kriebardis, Marianna Antonelou, Issidora Papassideri, Carolyn Young, Tiffany Thomas, Kirk C Hansen, Steven L Spitalnik, Yang Xia, James C Zimring, Eldad A Hod, Angelo D'Alessandro
Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and, most importantly, hydrogen peroxide. However, it is unclear whether accumulation of intracellular and supernatant hypoxanthine in stored RBC units is clinically relevant for transfused recipients. Leukoreduced RBCs from G6PD-normal or -deficient human volunteers were stored in AS-3 under normoxic, hyperoxic, or hypoxic conditions (with SO2 ranging from <3 to >95%). RBCs from healthy human volunteers were also collected at sea level or after 1-7 days at high altitude (>5000m)...
October 27, 2017: Haematologica
https://www.readbyqxmd.com/read/29078929/blood-product-transfusions-and-reactions
#16
REVIEW
Jessica L Osterman, Sanjay Arora
Blood product transfusions are an essential component of the practice of emergency medicine. From acute traumatic hemorrhage to chronic blood loss necessitating transfusion for symptomatic anemia, familiarity with individual blood products and their indications for transfusion is an essential tool for every emergency physician (EP). Although the focus of this article is primarily on the transfusion of red blood cells, many of the concepts are applicable to the transfusion of all blood products. EPs must be fully familiar with both the individual blood components and the potential reactions and complications of these transfusions...
December 2017: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29067906/the-age-of-blood-evaluation-able-randomised-controlled-trial-description-of-the-uk-funded-arm-of-the-international-trial-the-uk-cost-utility-analysis-and-secondary-analyses-exploring-factors-associated-with-health-related-quality-of-life-and-health-care-costs
#17
Timothy S Walsh, Simon Stanworth, Julia Boyd, David Hope, Sue Hemmatapour, Helen Burrows, Helen Campbell, Elena Pizzo, Nicholas Swart, Stephen Morris
BACKGROUND: At present, red blood cells (RBCs) are stored for up to 42 days prior to transfusion. The relative effectiveness and safety of different RBC storage times prior to transfusion is uncertain. OBJECTIVE: To assess the clinical effectiveness and cost-effectiveness of transfusing fresher RBCs (stored for ≤ 7 days) compared with current standard-aged RBCs in critically ill patients requiring blood transfusions. DESIGN: The international Age of BLood Evaluation (ABLE) trial was a multicentre, randomised, blinded trial undertaken in Canada, the UK, the Netherlands and France...
October 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29067785/pre-hospital-transfusion-of-red-blood-cells-in-civilian-trauma-patients
#18
M Rehn, A E Weaver, S Eshelby, J Røislien, D J Lockey
INTRODUCTION: The current management of severely injured patients includes damage control resuscitation strategies that minimise the use of crystalloids and emphasise earlier transfusion of red blood cells (RBC) to prevent coagulopathy. In 2012, London's air ambulance (LAA) became the first UK civilian pre-hospital service to routinely carry RBC to the trauma scene. OBJECTIVE: To investigate the effect of pre-hospital RBC transfusion (phRTx) on overall blood product consumption...
October 24, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29067705/demographic-and-epidemiologic-characterization-of-transfusion-recipients-from-four-us-regions-evidence-from-the-reds-iii-recipient-database
#19
Matthew S Karafin, Roberta Bruhn, Matt Westlake, Marian T Sullivan, Walter Bialkowski, Gustaf Edgren, Nareg H Roubinian, Ronald G Hauser, Daryl J Kor, Debra Fleischmann, Jerome L Gottschall, Edward L Murphy, Darrell J Triulzi
BACKGROUND: Blood transfusion is one of the most common medical procedures during hospitalization in the United States. To understand the benefits of transfusion while mitigating potential risks, a multicenter database containing detailed information on transfusion incidence and recipient outcomes would facilitate research. STUDY DESIGN AND METHODS: The Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) program has developed a comprehensive transfusion recipient database utilizing data from hospital electronic health records at 12 participating hospitals in four geographic regions...
October 24, 2017: Transfusion
https://www.readbyqxmd.com/read/29067694/administration-of-platelet-concentrates-suspended-in-bicarbonated-ringer-s-solution-in-children-who-had-platelet-transfusion-reactions
#20
J Kobayashi, R Yanagisawa, T Ono, Y Tatsuzawa, Y Tokutake, N Kubota, E Hidaka, K Sakashita, S Kojima, S Shimodaira, T Nakamura
BACKGROUND AND OBJECTIVES: Adverse reactions to platelet transfusions are a problem. Children with primary haematological and malignant diseases may experience allergic transfusion reactions (ATRs) to platelet concentrates (PCs), which can be prevented by giving washed PCs. A new platelet additive solution, using bicarbonated Ringer's solution and acid-citrate-dextrose formula A (BRS-A), may be better for platelet washing and storage, but clinical data are scarce. MATERIALS AND METHODS: A retrospective cohort study for consecutive cases was performed between 2013 and 2017...
October 25, 2017: Vox Sanguinis
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