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https://www.readbyqxmd.com/read/29322525/zika-virus-rna-polymerase-chain-reaction-on-the-utility-channel-of-a-commercial-nucleic-acid-testing-system
#1
Mohamed Boujnan, Ashley J Duits, Marco H G M Koppelman
BACKGROUND: Several countries have implemented safety strategies to reduce the risk of Zika virus (ZIKV) transmission through blood transfusion. These strategies have included nucleic acid amplification testing (NAT) of blood donations. In this study, a new real-time polymerase chain reaction (PCR) assay including internal control for the detection of ZIKV on the cobas omni Utility Channel (UC) on the cobas 6800 system is presented. STUDY DESIGN AND METHODS: PCR conditions and primer/probe concentrations were optimized on the LightCycler 480 instrument...
January 10, 2018: Transfusion
https://www.readbyqxmd.com/read/29318576/comparing-transfusion-reaction-risks-for-various-plasma-products-an-analysis-of-7%C3%A2-years-of-istare-haemovigilance-data
#2
Nicholas H Saadah, Johanna G van der Bom, Johanna C Wiersum-Osselton, Clive Richardson, Rutger A Middelburg, Constantina Politis, Philippe Renaudier, Pierre Robillard, Martin R Schipperus
Plasma transfusions may result in transfusion reactions. We used the International Surveillance of Transfusion-Associated Reactions and Events (ISTARE) database, containing yearly reported national annual aggregate data on transfusion reactions from participating countries, to investigate risks of plasma transfusion reactions and compare transfusion reaction risks for different plasma types. We calculated risks for plasma transfusion reactions and compared transfusion reaction risks between plasma types using random effects regression on repeated measures...
January 9, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29315622/patient-rescue-and-blood-utilization-in-the-ogasawara-blood-rotation-system
#3
Tomoko Igarashi, Hiroshi Fujita, Hiroyuki Asaka, Yuko Takada, Rieko Ametani, Itsuki Naya, Yasushi Tanaka, Makoto Kamesaki, Asuka Kasai
BACKGROUND: In the past, blood products were not transported to the Ogasawara Islands because of the distance; the islands are approximately 1000 km from the mainland and lack an airport. The Ogasawara Blood Rotation system involves the routine, long-distance transportation of Type O, RhD-positive, irradiated red blood cells to rescue patients with acute hemorrhage and severe anemia and to reduce wastage from the expiration of red blood cell solution. STUDY DESIGN AND METHODS: Blood transfusion and utilization in the Ogasawara blood rotation (BR) system were examined from December 2014 to March 2017...
January 7, 2018: Transfusion
https://www.readbyqxmd.com/read/29312561/therapeutic-effects-of-adipose-derived-mesenchymal-stem-cells-against-brain-death-induced-remote-organ-damage-and-post-heart-transplant-acute-rejection
#4
Hon-Kan Yip, Mel S Lee, Cheuk-Kwan Sun, Kuan-Hung Chen, Han-Tan Chai, Pei-Hsun Sung, Kun-Chen Lin, Sheung-Fat Ko, Chun-Man Yuen, Chu-Feng Liu, Pei-Lin Shao, Fan-Yen Lee
We tested the hypothesis that allogenic adipose-derived mesenchymal stem cells (ADMSCs) alleviated brain death (BD)-induced remote organ damage and events of post heart-transplant acute rejection. To determine the impact of BD on remote organ damage, adult-male F344 rats (n=24) were categorized sham-control (SC), BD and BDMSC (allogenic ADMSC/1.2 × 106 cells/derived from F344 by intravenous transfusion 3 h after BD procedure). To determine the protective effect of allogenic ADMSCs, animals (n=8/each group in F344/Lewis) were categorized into groups BD-T(F344 heart transplanted into Lewis by 6h after BD), BD-TMSC(D1/3) (BD induction for 6h then heart transplantation, and allogenic ADMSCs transfusion at days 1 and 5 after heart transplantation), BD-TMSC(3h) (BD + ADMSC/1...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29297831/whole-blood-transfusions-to-treat-severe-anemia-in-seven-cownose-rays-rhinoptera-bonasus-and-one-short-tail-stingray-dasyatis-brevicaudata
#5
Alexa J McDermott Delaune, Cara L Field, Tonya M Clauss
Blood transfusions can provide life-saving treatment to severely anemic animals. Due to limited availability and the difficulty of storing whole blood and blood products, such as fresh frozen plasma and packed red blood cells, exotic animals often receive fresh whole blood transfusions. Little is known about elasmobranch blood types and transfusions. Conspecific cross-matches within several different elasmobranch species were negative, indicating that in an emergency situation a single whole blood transfusion may be possible without causing a transfusion reaction...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29296844/potential-impact-of-complement-regulator-deficiencies-on-hemolytic-reactions-due-to-minor-abo-mismatched-transfusions
#6
Priyanka Pandey, Waseem Q Anani, Jerome L Gottschall, Gregory A Denomme
Minor ABO-mismatched transfusions are a common occurrence, although infrequent transfusion reactions occur. We sought to investigate the regulation of complement C3 activation induced by anti-A. In vitro complement C3 activation was observed with 10 of 30 group O samples and correlated with immunoglobulin M (IgM) anti-A titers. We developed an in vitro paroxysmal nocturnal hemoglobinuria (PNH) model of hemolysis in which group A1 red blood cells (RBCs) were chemically treated with 2-aminoethylisothiouronium (AET) to alter regulators of complement C3 activation...
October 24, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296756/implications-of-the-us-food-and-drug-administration-draft-guidance-for-mitigating-septic-reactions-from-platelet-transfusions
#7
Bruce S Sachais, Sarai Paradiso, Donna Strauss, Beth H Shaz
No abstract text is available yet for this article.
June 27, 2017: Blood Advances
https://www.readbyqxmd.com/read/29289486/posterior-reversible-encephalopathy-syndrome-following-blood-transfusion-in-a-patient-with-factor-x-deficiency-is-it-an-unusual-systemic-manifestation-of-an-adverse-transfusion-reaction
#8
Anupam Verma, Hemlata, Priti Elhence, Shubha R Phadke, Zafar Neyaz
Adverse neurological transfusion reactions including posterior reversible encephalopathy syndrome (PRES) following blood transfusion are rare. Our case an 18-year-female with known Factor X deficiency with menorrhagia developed severe hypertension, followed by generalised tonic clonic convulsions apparently after blood component transfusion. She had earlier received 4 units of red blood cells (RBC) for anaemia and 10 units of fresh frozen plasma (FFP) for menorrhagia (with prolonged PT and APTT) within short span of time at another hospital...
December 6, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29286568/utilization-of-frozen-plasma-cryoprecipitate-and-recombinant-factor-viia-for-children-with-hemostatic-impairments-an-audit-of-transfusion-appropriateness
#9
Lani Lieberman, Yulia Lin, Christine Cserti-Gazdewich, Qi Long Yi, Jacob Pendergrast, Wendy Lau, Jeannie Callum
BACKGROUND: Blood transfusions and fractionated products are not without risk and may lead to acute and long-term adverse events. The objective of this study was to evaluate the appropriateness of usage of frozen plasma (FP), cryoprecipitate (CRYO), and recombinant factor VIIa (rVIIa) in a pediatric setting. METHODS: All orders for FP, CRYO, and rVIIa were prospectively audited over 6 weeks. Data collected included demographics, laboratory values, indication, and adverse reactions...
December 29, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29277907/a-multicentre-study-investigating-vital-sign-changes-occurring-in-complicated-and-uncomplicated-transfusions
#10
E A Gehrie, N H Roubinian, D Chowdhury, D J Brambilla, E L Murphy, J L Gottschall, Y Wu, P M Ness, R G Strauss, J E Hendrickson
BACKGROUND AND OBJECTIVES: Many hospitals require transfusions to be discontinued when vital signs stray from predetermined ranges, regardless of clinical symptoms. Variations in vital signs may be unrelated to transfusion, however, and needlessly stopping a transfusion may delay medical care while increasing donor exposures and healthcare costs. We hypothesized that a detailed study of vital sign changes associated with transfusion of blood product by component, including those associated with potential reactions (complicated) and those deemed to be uncomplicated, would establish a useful framework of reference for treating clinicians and transfusion services alike...
December 25, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29273503/-is-the-research-of-posttransfusional-alloantibodies-still-relevant
#11
C Le Niger, C André, V Bourcier, L Augey, A Bazin, E Berger, V Betbeze, A Damais-Cepitelli, G Daurat, E De Meyer, S Ducroz, H Gouezec, C Huchet, B Lassale, S Leo-Kodeli, V Lovi, M Puntous, S Pujol, P Renom, C Rieux
The decision of November 6th, 2006 defining the principles of best practices recommends that posttransfusional red cell alloantibodies research is performed after one to three months after. In the University hospital of Brest, the haemovigilance unit takes charge of sending the medical prescription within the required time and centralizing the results. We wished to estimate if the realization of this research still remains relevant. METHODS: A prospective analysis was performed in 2015...
December 19, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29260743/-impact-of-current-approaches-to-laboratory-screening-of-donated-blood-and-its-components-on-hepatitis-b-virus-infection-in-patients-with-blood-system-diseases
#12
E N Ignatova, T A Tupoleva, E N Ovchinnikova, T Yu Romanova, N G Yaroslavtseva, F P Filatov, V V Troitskaya, L A Kuzmina, E N Parovichnikova, T V Gaponova, V G Savchenko
AIM: To evaluate the detection rate of markers for hepatitis B virus (HBV) in the blood samples taken from patients with blood system diseases, by applying the current approaches to examining donated blood and its components for markers of viral infections. MATERIAL AND METHODS: The investigation included blood samples from patients with blood system diseases (n=364) and donors (n=5,011). The results of laboratory screening of donated blood samples (n=13,081) were retrospectively analyzed...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29258541/intravenous-iron-vs-blood-for-acute-post-partum-anaemia-iibappa-a-prospective-randomised-trial
#13
Seng Chua, Sarika Gupta, Jennifer Curnow, Beata Gidaszewski, Marjan Khajehei, Hayley Diplock
BACKGROUND: Acute post-partum anaemia can be associated with significant morbidity including a predisposition for postnatal depression. Lack of clear practice guidelines means a number of women are treated with multiple blood transfusions. Intravenous iron has the potential to limit the need for multiple blood transfusions but its role in the post-partum setting is unclear. METHODS/DESIGN: IIBAPPA is a multi-centre randomised non-inferiority trial. Women with a primary post-partum haemorrhage (PPH) >1000 mL and resultant haemoglobin (Hb) 5...
December 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29250787/metagenomics-in-pooled-plasma-with-identification-of-potential-emerging-infectious-pathogens
#14
Min Xu, Yashan Yang, Ya Zhou, Zhiyang Liu, Yu Liu, Miao He
BACKGROUND: Many emerging infectious pathogens are well known for existing in healthy blood donors and could be transmitted via blood transfusion or plasma derivatives usage. Therefore, there is an urgent need to discover the pathogens in qualified blood donation to avoid potential threats to blood safety. STUDY DESIGN AND METHODS: The objective of this study was to investigate the microbiome that existed in pooled plasma from different manufacturers in Chengdu and Guiyang...
December 17, 2017: Transfusion
https://www.readbyqxmd.com/read/29247544/removal-of-hemangiosarcoma-cells-from-canine-blood-with-a-cell-salvage-system-and-leukocyte-reduction-filter
#15
Brittany Ciepluch, Heather Wilson-Robles, Gwendolyn Levine, Roger Smith, Gus A Wright, Tasha Miller, Maureen T O'Brien, Kelley M Thieman Mankin
OBJECTIVE: To determine the ability of an intraoperative cell salvage (IOCS) system and a leukocyte reduction filter (LRF) to remove hemangiosarcoma (HSA) cells from canine blood. STUDY DESIGN: Cultured HSA cells were added to canine blood to simulate intraoperative hemorrhage and address hemoabdomen from ruptured splenic HSA. The blood/HSA cell mixture was processed through an IOCS, followed by LRF processing. SAMPLE POPULATION: Whole blood from 3 healthy dogs combined with cultured HSA cells...
December 16, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29239484/inactivation-of-middle-east-respiratory-syndrome-coronavirus-in-human-plasma-using-amotosalen-and-ultraviolet-a-light
#16
Salwa I Hindawi, Anwar M Hashem, Ghazi A Damanhouri, Sherif A El-Kafrawy, Ahmed M Tolah, Ahmed M Hassan, Esam I Azhar
BACKGROUND: Middle East respiratory syndrome-coronavirus (MERS-CoV) is a novel zoonotic pathogen. Although the potential for MERS-CoV transmission through blood transfusion is not clear, MERS-CoV was recognized as a pathogen of concern for the safety of the blood supply especially after its detection in whole blood, serum, and plasma of infected individuals. Here we investigated the efficacy of amotosalen and ultraviolet A light (UVA) to inactivate MERS-CoV in fresh-frozen plasma (FFP)...
December 14, 2017: Transfusion
https://www.readbyqxmd.com/read/29238987/modeling-the-effect-of-platelet-concentrate-supernatants-on-endothelial-cells-focus-on-endocan-esm-1
#17
Sofiane Tariket, Caroline Sut, Charles-Antoine Arthaud, Marie-Ange Eyraud, Astrid Meneveaux, Sandrine Laradi, Hind Hamzeh-Cognasse, Olivier Garraud, Fabrice Cognasse
BACKGROUND: Platelets (PLTs) are prone to activation and the release of biologic response modifiers (BRMs) under storage conditions. The transfusion inflammatory reaction in the vascular compartment involves endothelial cell activation due to cell-cell interactions and BRMs infused with the blood products. Endocan/ESM-1 is a proteoglycan secreted by endothelial cells under the control of proinflammatory cytokines. We aimed to measure endocan activity in supernatants of PLT components (PCs), implicated in serious adverse reactions (SARs) or not (no...
December 13, 2017: Transfusion
https://www.readbyqxmd.com/read/29238698/detection-of-merkel-cell-polyomavirus-dna-in-serum-samples-of-healthy-blood-donors
#18
Elisa Mazzoni, John C Rotondo, Luisa Marracino, Rita Selvatici, Ilaria Bononi, Elena Torreggiani, Antoine Touzé, Fernanda Martini, Mauro G Tognon
Merkel cell polyomavirus (MCPyV) has been detected in 80% of Merkel cell carcinomas (MCC). In the host, the MCPyV reservoir remains elusive. MCPyV DNA sequences were revealed in blood donor buffy coats. In this study, MCPyV DNA sequences were investigated in the sera (n = 190) of healthy blood donors. Two MCPyV DNA sequences, coding for the viral oncoprotein large T antigen (LT), were investigated using polymerase chain reaction (PCR) methods and DNA sequencing. Circulating MCPyV sequences were detected in sera with a prevalence of 2...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29223725/transfusion-associated-circulatory-overload-a-survey-among-dutch-intensive-care-fellows
#19
R B Klanderman, I Attaye, J J Bosboom, D P Veelo, B F Geerts, A P J Vlaar
OBJECTIVES: Transfusion-associated circulatory overload (TACO) is a severe pulmonary transfusion reaction and leading cause of transfusion-related morbidity and mortality in Europe. TACO is of particular importance in critically ill patients, since they often receive blood transfusions and have multiple risk factors for TACO. This study investigates transfusion practices in patients at risk of developing TACO, and furthermore knowledge concerning risk factors, diagnoses and treatment strategies among Dutch intensive care unit (ICU) fellows...
December 6, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29214792/life-threatening-thrombocytopenia-following-intravenous-contrast-media-infusion
#20
Mihwa Park, Minjeong Kim, Jisun Park, Jinhyun Cho
Radiocontrast media-induced acute severe thrombocytopenia is a very rare complication and potentially life-threatening. Here, we report the case of a 63-year-old male patient with severe acute thrombocytopenia following first exposure to intravenous non-ionic contrast media without immediate allergic reactions. His platelet count dropped from 107000/μL to 2000/μL after six hours of radiocontrast infusion. After administration of corticosteroid and transfusion of platelet concentrates, the platelet count returned gradually to normal within 5 days...
January 2018: Yonsei Medical Journal
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