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https://www.readbyqxmd.com/read/28345172/international-prospective-haemovigilance-study-on-methylene-blue-treated-plasma
#1
L Noens, Ma D Vilariño, A Megalou, H Qureshi
BACKGROUND AND OBJECTIVES: Methylene blue is a phenothiazine dye, which in combination with visible light has virucidal and bactericidal properties, disrupting the replication of a broad range of enveloped viruses and some non-enveloped viruses. The study objective was to collect data on adverse reactions occurring with methylene blue plasma administered in a routine clinical practice environment and document their characteristics and severity. MATERIALS AND METHODS: This was an open label, multicentre, non-controlled, non-randomized, non-interventional study...
March 26, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28343935/blood-derived-products-in-pediatrics-new-laboratory-tools-for-optimizing-potency-assignment-and-reducing-side-effects
#2
REVIEW
Jean Amiral, Jerard Seghatchian
Neonates and children can develop rare bleeding disorders due to congenital/acquired coagulation Factor deficiencies, or allo-immune/autoimmune complications, or can undergo surgeries at high haemorrhagic risk. They then need specialized transfusion of blood components/products, or purified blood extracted products or recombinant proteins. Blood-derived therapies conventionally used for management of affected infants with genetic/acquired deficiencies, bleeding problems (coagulation Factor reduced or missing) or thrombotic disorders (reduced or missing anticoagulant proteins) pose some additional risks...
March 15, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28340116/platelet-transfusion-reactions-with-respect-to-transfusion-indications-a-single-center-analysis
#3
Alexander Z Feldman, Elizabeth M Staley, Lance A Williams, Huy P Pham
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28340097/viral-infection-prevents-hemolytic-transfusion-reactions-following-incompatible-red-blood-cell-transfusion
#4
Harold Sullivan, Connie Arthur, Andreas Wieland, Rafi Ahmed, Sean Stowell
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28338491/perioperative-management-of-blood-loss-in-spine-surgery
#5
Rabia Qureshi, Varun Puvanesarajah, Amit Jain, Hamid Hassanzadeh
Spine procedures are associated with high rates of blood loss which can result in a greater need for transfusions. Repeated exposure to blood products is associated with risks and adverse reactions such as transfusion-related acute lung injury, fluid shifting, and infections. With the higher number of spine procedures and the increasing open surgery times associated with difficult procedures, excessive blood loss has become more prevalent. Perioperative methods have been established to combat the excessive blood loss and decrease the need for blood products...
March 23, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28321548/demethylating-agent-decitabine-disrupts-tumor-induced-immune-tolerance-by-depleting-myeloid-derived-suppressor-cells
#6
Jihao Zhou, Yushi Yao, Qi Shen, Guoqiang Li, Lina Hu, Xinyou Zhang
PURPOSE: The immunoregulatory effect of demethylating agent decitabine (DAC) has been recognized recently. However, little is known about its impact on immune tolerance. In this study, we aimed to determine the impact of DAC on the immune tolerance induced by tumor cells. METHODS: The effects of DAC on immune cells in vivo were measured by flow cytometry. Myeloid-derived suppressor cells (MDSCs) were sorted using magnetic beads and cultured in vitro. The mixed lymphocyte reaction was used to determine the immunoregulatory effect of DAC in vitro...
March 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28316441/snake-in-the-grass-a-case-report-of-transfusion-reactions-due-to-contaminated-donor-arm-disinfectant
#7
Anju Dubey, Atul Sonker, Rajendra Chaudhary
Bacterial contamination of blood components remains an on-going challenge. In the majority of cases, organisms contaminating the blood components are a part of normal skin flora. Here, we report a case of bacterial contamination of blood units through contaminated donor arm disinfectant. There was a series of reactions due to random donor platelet (RDP) transfusion. The patients had features of septic transfusion reactions. On root cause analysis, spirit swabs used for disinfection of donors' arm were identified as the culprit and presence of Clostridium difficile was established...
January 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28316440/abo-incompatible-renal-transplant-transfusion-medicine-perspective
#8
Raj Nath Makroo, Sweta Nayak, Mohit Chowdhry, Sanjiv Jasuja, Gaurav Sagar, N L Rosamma, Uday Kumar Thakur
INTRODUCTION: Our study presents an analysis of the trends of ABO antibody titers and the TPE (Therapeutic Plasma Exchange) procedures required pre and post ABO incompatible renal transplant. MATERIALS AND METHODS: Twenty nine patients underwent ABO incompatible renal transplant during the study period. The ABO antibody titers were done using the tube technique and titer reported was the dilution at which 1+ reaction was observed. The baseline titers of anti-A and anti-B antibodies were determined...
January 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28316439/first-indian-study-to-establish-safety-of-immediate-spin-crossmatch-for-red-blood-cell-transfusion-in-antibody-screen-negative-recipients
#9
Aseem Kumar Tiwari, Geet Aggarwal, Ravi C Dara, Dinesh Arora, Gautam Kumar Gupta, Vimarsh Raina
BACKGROUND AND OBJECTIVES: The US Food and Drug Administration and American Association of Blood Banks approved the type and screen approach in 1980s, long after antibody screen (AS) was introduced in 1950s. The present study omits conventional anti-human globulin (AHG) crossmatch and replaces it with immediate-spin (IS) crossmatch as part of pretransfusion testing in AS-negative patients to study the safety and effectiveness of IS crossmatch in recipients. MATERIALS AND METHODS: This prospective longitudinal study was conducted on over 5000 red cell units transfused to AS-negative patients admitted to the hospital...
January 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28316436/antibody-titers-in-group-o-platelet-donors
#10
Anita Amar Tendulkar, Puneet Ashok Jain, Sanjay Velaye
BACKGROUND AND OBJECTIVES: The occurrence of hemolysis due to transfusion of ABO plasma-incompatible platelets (PLTs) is challenging. There has been no consensus for critical antibody titers in the transfusion community. This study was conducted to understand the trends of anti-A and anti-B antibody titer levels in O group donors and to identify any specific patterns of distribution in relation to age and gender. MATERIALS AND METHODS: A total of 1635 Group O PLT donors were randomly selected for this prospective study...
January 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28316433/reporting-adverse-transfusion-reactions-a-retrospective-study-from-tertiary-care-hospital-from-new-delhi-india
#11
Sangeeta Pahuja, Vandana Puri, Gunjan Mahajan, Prajwala Gupta, Manjula Jain
CONTEXT: Blood transfusion services have achieved newer heights in the last decade, with developments in cellular techniques, component separation, and integration of molecular methods. However, the system of recording and reporting of the adverse events related to blood transfusion is developing countries like India is grossly inadequate and voluntary in nature. AIMS: This study was undertaken to analyze the retrospective data on adverse events related to blood transfusions in our hospital...
January 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28301394/effects-on-the-anti-abo-titers-of-military-blood-donors-from-a-predeployment-vaccination-program
#12
Olle Berséus
BACKGROUND: The use of blood group O as "universal blood" for emergency whole blood transfusions carries the risk for a hemolytic transfusion reaction mediated by incompatible A-/B-antibodies. This risk can be minimized by assuring that the donor has a low titer of anti-A and anti-B. The level of these naturally occurring antibodies have been shown to be increased by vaccination with most biologically derived vaccines. This boostering effect has been investigated for the new generation of vaccines...
March 15, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28301053/blood-transfusion-knowledge-of-surgical-residents-is-an-educational-intervention-effective
#13
Caitlin Champion, Elianna Saidenberg, Jacinthe Lampron, Debra Pugh
BACKGROUND: Evidence-based transfusion education for surgical residents is crucial to improving practice. A pilot study was undertaken to assess the effectiveness of an education module for improving transfusion knowledge among surgical residents. METHODS: Modules were developed and delivered by experts in surgery and transfusion medicine. They were delivered to residents in their first 2 years of training (Surgical Foundations), and to General Surgery residents across all years of training...
March 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28295356/red-blood-cell-metabolic-responses-to-refrigerated-storage-rejuvenation-and-frozen-storage
#14
Angelo D'Alessandro, Alan D Gray, Zbignew M Sczcepiorkowski, Kirk Hansen, Louise H Herschel, Larry J Dumont
BACKGROUND: Storage of red blood cells (RBCs) under blood bank conditions promotes metabolic modulation within the RBC. This "metabolic storage lesion" may affect the quality and safety of the transfused RBCs. The aim of this study is to determine the metabolic changes in stored RBCs over 42 days of routine storage followed by a US Food and Drug Administration-approved method of rejuvenation, freezing, and preparation for transfusion. STUDY DESIGN AND METHODS: We exploited a mass spectrometry-based metabolomics approach to monitor 42-day-stored citrate phosphate dextrose/AS-1 RBCs (n = 29) that were rejuvenated, glycerolized and frozen, then thawed and deglycerolized, and held for 24 hours at 1 to 6ºC in saline-glucose...
March 10, 2017: Transfusion
https://www.readbyqxmd.com/read/28286630/a-fatal-case-of-immune-hyperhemolysis-with-bone-marrow-necrosis-in-a-patient-with-sickle-cell-disease
#15
Matthew S Karafin, Arun Singavi, Susan T Johnson, Joshua J Field
In patients with sickle cell disease, hyperhemolysis is a rare but life-threatening complication of transfusion. In this case report, we describe a 61 year-old woman with hemoglobin sickle cell (SC) disease and history of alloimmunization who developed hyperhemolysis associated with a transfusion. She was found to have a warm and a clinically-significant cold autoantibody. Severe anemia (Hb 2.7 g/dL) with reticulocytopenia and thrombocytopenia prompted a bone marrow biopsy, which demonstrated extensive bone marrow necrosis...
February 23, 2017: Hematology Reports
https://www.readbyqxmd.com/read/28285862/comparing-the-effectiveness-of-vapocoolant-spray-and-lidocaine-procaine-cream-in-reducing-pain-of-intravenous-cannulation-a-randomized-clinical-trial
#16
Asghar Dalvandi, Hadi Ranjbar, Maryam Hatamizadeh, Abolfazl Rahgoi, Colleen Bernstein
INTRODUCTION: Venous cannulation is the most common procedure in emergency departments. The aim of this study was to compare the effectiveness of vapocoolant spray and EMLA cream in reduction of pain during venous cannulation in 6-12years old children. METHODS: The study was a randomized clinical trial with a crossover design. It took place between June and December 2015 at Ali-Asghar hospital in Tehran, Iran. 40 Thalassemic children who need regular blood transfusions were randomly assigned in two groups...
February 27, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28285590/molecular-detection-of-hepatozoon-spp-and-cytauxzoon-sp-in-domestic-and-stray-cats-from-madrid-spain
#17
David Díaz-Regañón, Alejandra Villaescusa, Tania Ayllón, Fernando Rodríguez-Franco, Gad Baneth, Lydia Calleja-Bueno, Mercedes García-Sancho, Beatriz Agulla, Ángel Sainz
BACKGROUND: Different species of apicomplexan protozoans of the genera Hepatozoon and Cytauxzoon can infect domestic cats, but their epidemiology and clinical relevance are not fully understood. The aim of this study was to assess the molecular prevalence of Hepatozoon spp. and Cytauxzoon spp. and to identify associated risk factors and clinical and laboratory abnormalities in a population of cats from Madrid, Spain. METHODS: Six hundred and forty-four client-owned and stray cats from Madrid, Spain, were included in this study...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28271517/effect-of-storage-time-of-platelet-products-on-clinical-outcomes-after-transfusion-a-systematic-review-and-meta-analyses
#18
REVIEW
A L Kreuger, C Caram-Deelder, J Jacobse, J-L Kerkhoffs, J G van der Bom, R A Middelburg
BACKGROUND: Prolonged storage improves availability of platelet products but could also influence safety and efficacy. This systematic review and meta-analyses summarize and quantify the evidence of the effect of storage time of transfused platelets on clinical outcomes. METHODS: A systematic search in seven databases was performed up to February 2016. All studies reporting storage time of platelet products and clinical outcomes were included. To quantify heterogeneity, I² was calculated, and to assess publication bias, funnel plots were constructed...
March 7, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28263170/the-accumulation-of-lipids-and-proteins-during-red-blood-cell-storage-the-roles-of-leucoreduction-and-experimental-filtration
#19
REVIEW
Christopher C Silliman, Timothy Burke, Marguerite R Kelher
Pre-storage leucoreduction has been universally adopted in most developed countries in Asia, Europe and the Americas. It decreases febrile transfusion reactions, alloimmunisation to HLA antigens, cytomegalovirus exposure, the accumulation of a number of pro-inflammatory mediators in the supernatant, including the accumulation of platelet-and leucocyte-derived proteins and metabolites during routine storage. This review will highlight the lipids and proteins, biological response modifiers (BRMs) that accumulate, their clinical effects in transfused hosts, and methods of mitigation...
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28257412/clinical-effect-and-prognosis-of-off-pump-minimally-invasive-direct-coronary-artery-bypass
#20
Ming Yang, Lian-Bo Xiao, Zhi-Sheng Gao, Ji-Wu Zhou
BACKGROUND Coronary artery bypass grafting (CABG) is a common procedure to circumvent the obstruction of coronary arteries when stents are unsuitable. CABG is a very traumatic surgery that requires redirecting blood flow to an external pump. Thus, this procedure has many risks during and after surgery, and minimizing these risks would greatly benefit the patients. MATERIAL AND METHODS We selected 126 patients with coronary artery syndrome and who were unsuitable for stent percutaneous coronary intervention...
March 3, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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