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https://www.readbyqxmd.com/read/28434577/50-years-ago-in-the-journal-of-pediatrics-thymic-dysplasia-swiss-agammaglobulinemia-i-graft-versus-host-reaction-following-bone-marrow-transfusion
#1
Emily Heikamp, Caridad Martinez
No abstract text is available yet for this article.
May 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28425749/hemolytic-transfusion-reaction-attributable-to-anti-dia
#2
Arthur J Joyce, Kelli M Quantock, Ray Banh, Yew W Liew
In situations when a patient's antibody detection test is negative, many institutions have moved from an indirect antiglobulin test (IAT) crossmatch to an electronic crossmatch system. Here we report a case of an acute hemolytic transfusion reaction attributable to anti-Dia in a patient with a negative antibody detection test. A 22-year-old female patient with a diagnosis of β thalassemia and sickle cell anemia commenced a routine exchange transfusion of 5 units of red blood cells (RBCs) in the apheresis unit as part of her regular treatment...
January 2017: Immunohematology
https://www.readbyqxmd.com/read/28425609/clostridium-perfringens-sepsis-masquerading-as-a-hemolytic-transfusion-reaction
#3
Alexander L Greninger, John R Hess
No abstract text is available yet for this article.
May 2017: Transfusion
https://www.readbyqxmd.com/read/28425607/reducing-the-risk-of-septic-transfusion-reactions-from-platelets
#4
EDITORIAL
Peter A Tomasulo
No abstract text is available yet for this article.
May 2017: Transfusion
https://www.readbyqxmd.com/read/28424235/increased-alloimmunisation-and-transfusion-reaction-reporting-in-patients-with-solid-phase-panreactivity
#5
Andrea M Olofson, Rachael M Chandler, Cynthia R Marx-Wood, Craig A Babcock, Nancy M Dunbar
BACKGROUND: Automated solid-phase antibody screening uses red blood cell (RBC) membranes immobilised on polystyrene test wells to detect RBC specific antibodies. Despite its time-saving and labour-saving benefits, this method produces a higher rate of nonspecific reactivity compared with manual screening. Solid-phase panreactivity (SPP) is characterised by panreactivity (ie, all test cells reacting) in solid-phase testing accompanied by a negative autocontrol and a lack of reactivity when the same screening cells are tested in tube...
April 19, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28419477/the-effectiveness-of-riboflavin-and-ultraviolet-light-pathogen-reduction-technology-in-eliminating-trypanosoma-cruzi-from-leukoreduced-whole-blood
#6
Teresa Jimenez-Marco, Beatriz Cancino-Faure, Enrique Girona-Llobera, M Magdalena Alcover, Cristina Riera, Roser Fisa
BACKGROUND: The parasitic Chagas disease is caused by the protozoan Trypanosoma cruzi, which is mainly transmitted by insect vectors. Other infection routes, both in endemic and in nonendemic areas, include organ and marrow transplantation, congenital transmission, and blood transfusion. Asymptomatic chronic chagasic individuals may have a low and transient parasitemia in peripheral blood and, consequently, they can unknowingly transmit the disease via blood transfusion. Riboflavin and ultraviolet (UV) light pathogen reduction is a method to reduce pathogen transfusion transmission risk based on damage to the pathogen nucleic acids...
April 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28414063/hypersensitivity-transfusion-reactions-due-to-iga-deficiency-are-rare-according-to-french-hemovigilance-data
#7
Charles Tacquard, Karim Boudjedir, Monique Carlier, Jean-Yves Muller, Philippe Gomis, Paul Michel Mertes
In an analysis of a large French hemovigilance database (2004-2014), hypersensitivity transfusion reactions (HTRs) due to IgA deficiency were extremely rare with an frequency far lower than reported so far. In depth investigation of HTRs for IgA deficiency should be limited to moderate to severe recurrent reactions.
April 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28410671/dog-erythrocyte-antigens-dea-1-4-7-and-suspected-naturally-occurring-anti-dea-7-antibodies-in-italian-corso-dogs
#8
E Spada, D Proverbio, V Priolo, D Ippolito, L Baggiani, R Perego, M G Pennisi
We sought to determine the prevalence of dog erythrocyte antigen (DEA) 1, 4 and 7 and naturally occurring anti-DEA7 antibodies in Italian Corso dogs. In addition, we correlated DEAs with different epidemiologic variables, compared the prevalence of DEAs against other canine populations and assessed the risk of sensitisation and transfusion reactions (TRs) following unmatched transfusion. Blood samples from 100 Corso dogs were evaluated for DEA 1, 4, 7 and naturally occurring anti-DEA 7 antibodies. Seventy-one percent of samples were DEA 1-negative, 100% tested DEA 4-positive, and 95% tested DEA 7-negative...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28410562/superior-vena-cava-reconstruction-under-the-left-internal-jugular-vein-to-left-femoral-vein-bypass-support
#9
Jun Ba, Runsheng Peng, Hui Shi, Chunsheng Wang
The complete surgical resection of malignant thymoma is recommended. We present a rare case of tumor resection and superior vena cava (SVC) reconstruction under veno-venous bypass support from the left internal jugular vein to the left femoral vein. The full amount of systemic heparinization (3 mg/kg) was avoided. The surgical pathology revealed thymic squamous cell carcinoma. No complications such as fatal extensive bleeding, coagulopathy, thromboembolism or transfusion reaction were found postoperatively...
April 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28409093/first-case-of-invasive-magnusiomyces-capitatus-infection-in-slovakia
#10
Dominika Tanuskova, Julia Horakova, Peter Svec, Ivana Bodova, Martina Lengerova, Matej Bezdicek, Miroslava Poczova, Jozef Koppl, Alexandra Kolenova
Magnusiomyces capitatus (previously known as Geotrichum capitatum or Blastoschizomyces capitatus or Trichosporon capitatum) is a rare cause of fungal infection in immunocompromised patients. Most of these cases (87%) have been reported from the Mediterranean region, as it is extremely rare to recognize it in other regions. Here we report a first case of disseminated M. capitatus infection in Slovakia. The patient - 19 year old woman with myelodysplastic syndrome was diagnosed with M. capitatus fungemia after allogeneic stem cell transplantation...
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28401102/human-parvovirus-b19-in-patients-with-beta-thalassemia-major-from-tehran-iran
#11
Seyed Ali Mohammad Arabzadeh, Farideh Alizadeh, Ahmad Tavakoli, Hamidreza Mollaei, Farah Bokharaei-Salim, Gharib Karimi, Mohammad Farahmand, Helya Sadat Mortazavi, Seyed Hamidreza Monavari
BACKGROUND: Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran. METHODS: This cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major...
March 2017: Blood Research
https://www.readbyqxmd.com/read/28397426/study-of-cd69-antigen-expression-and-integrity-of-leukocyte-cellular-membrane-in-stored-platelet-concentrates-following-irradiation-and-treatment-with-mirasol%C3%A2-prt-system
#12
Elżbieta Lachert, Jolanta Woźniak, Jolanta Antoniewicz-Papis, Agnieszka Krzywdzińska, Jolanta Kubis, Agata Mikołowska, Magdalena Letowska
BACKGROUND: Leukocytes in transfused blood components, particularly residual lymphocytes, have been shown to contribute to the occurrence of various adverse reactions. One of the most severe is transfusionassociated graft versus host disease (TA-GvHD) following transfusion of blood components contaminated with immunocompetent T lymphocytes. Irradiation is a routine method for protection against TA-GvHD. According to the literature, some pathogen reduction methods have also been proven effective for the inactivation of T lymphocytes, and so they may be considered as an alternative to irradiation...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28395370/intra-articular-tranexamic-acid-in-primary-total-knee-arthroplasty-meta-analysis
#13
Joseph T Moskal, Susan G Capps
Total knee arthroplasty (TKA) is associated with an increased need for blood transfusions and thus an increase in risks associated with blood transfusion such as transfusion reactions, infections, fluid overload, and altered mental status. Tranexamic acid (TXA) is an antifibrinolytic medication that can reduce perioperative blood loss in TKA. However, the best method of delivery has not been defined although topical intra-articular TXA (IA-TXA) may have a theoretical advantage as it is applied directly when and where it is needed to control bleeding...
April 10, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28394029/hepatitis-e-in-canadian-blood-donors
#14
Margaret A Fearon, Sheila F O'Brien, Gilles Delage, Vito Scalia, France Bernier, Mark Bigham, Steven Weger, Sneha Prabhu, Anton Andonov
BACKGROUND: Hepatitis E virus (HEV) is a virus of emerging importance to transfusion medicine as studies on blood donors and other populations demonstrate that the prevalence of endemic cases is higher than previously recognized and the risk to vulnerable transfusion recipients is not insignificant. STUDY DESIGN AND METHODS: We carried out an HEV prevalence study on 13,993 Canadian blood donors with polymerase chain reaction (PCR) testing on all donors and antibody testing on a subset of 4102 donors...
April 10, 2017: Transfusion
https://www.readbyqxmd.com/read/28389344/emergency-transfusion-of-patients-with-unknown-blood-type-with-blood-group-o-rhesus-d-positive-red-blood-cell-concentrates-a-prospective-single-centre-observational-study
#15
Kathleen Selleng, Gregor Jenichen, Kathrin Denker, Sixten Selleng, Bernd Müllejans, Andreas Greinacher
BACKGROUND: Emergency patients with unknown blood type usually receive O Rhesus D negative (RhD-) red blood cell concentrates until their blood group is determined to prevent RhD+ related adverse transfusion reactions. As 85% of individuals are RhD+, this consumption of O RhD- red blood cell concentrates contributes to shortages of O RhD- red blood cell concentrates, sometimes forcing transfusion of known RhD- patients with RhD+ red blood cell concentrates. Here we report the outcome of this transfusion policy transfusing all emergency patients with unknown blood type with O RhD+ red blood cell concentrates...
April 4, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28388467/rhd-and-rhce-genotyping-by-next-generation-sequencing-is-an-effective-strategy-to-identify-molecular-variants-within-sickle-cell-disease-patients
#16
Marcia R Dezan, Ingrid Helena Ribeiro, Valéria B Oliveira, Juliana B Vieira, Francisco C Gomes, Lucas A M Franco, Leonardo Varuzza, Roberto Ribeiro, Karen Ziza Chinoca, José Eduardo Levi, José Eduardo Krieger, Alexandre Costa Pereira, Sandra F M Gualandro, Vanderson G Rocha, Alfredo Mendrone-Junior, Ester Cerdeira Sabino, Carla Luana Dinardo
BACKGROUND: The complexity of Rh genetic variation among sickle cell disease (SCD) patients is high. Conventional molecular assays cannot identify all genetic variants already described for the RH locus as well as foresee novel alleles. Sequencing RHD and RHCE is indicated to broaden the search for Rh genetic variants. AIMS: To standardize the Next Generation Sequencing (NGS) strategy to assertively identify Rh genetic variants among SCD patients with serologic suspicion of Rh variants and evaluate if it can improve the transfusion support...
March 31, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28382707/improving-transfusion-education-for-junior-doctors-exploring-uk-experiences
#17
J E Graham, S Narayan, K Pendry
OBJECTIVES: To provide evidence-based guidance on how transfusion education should be delivered to junior doctors by employing established qualitative research methodology. BACKGROUND: There is a global call for increased transfusion education for doctors to support the delivery of evidence-based practice. Education is reported as an effective measure to improve transfusion practice, although there is a paucity of research evaluating how this should be effectively delivered...
April 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28377559/recent-advances-in-understanding-the-clinical-relevance-of-antiplatelet-alloantibodies
#18
Katarzyna Guz, Małgorzata Uhrynowska, Izabella Kopeć, Marzena Dębska, Anne Husebekk, Ewa Brojer
Alloimmunization to human platelet antigens (HPAs) may occur either during pregnancy, when a HPA‑negative mother gives birth to a newborn who inherits HPAs from the father, or following blood transfusion or stem cell transplantation. Antiplatelet alloantibodies do not cause thrombocytopenia in a patient, but their detection must always be recorded in medical records because they may induce fetal and neonatal alloimmune thrombocytopenia in present and all subsequent pregnancies, platelet refractoriness, posttransfusion purpura, or prolonged thrombocytopenia with engraftment failure after stem cell transplantation...
March 31, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28371931/critical-value-reporting-in-transfusion-medicine-a-survey-of-communication-practices-in-us-facilities
#19
Erika M Reese, Randin C Nelson, Willy A Flegel, Karen M Byrne, Garrett S Booth
Objectives: While critical value procedures have been adopted in most areas of the clinical laboratory, their use in transfusion medicine has not been reviewed in detail. The results of this study present a comprehensive overview of critical value reporting and communication practices in transfusion medicine in the United States. Methods: A web-based survey was developed to collect data on the prevalence of critical value procedures and practices of communicating results...
March 21, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28369916/feeling-the-burn-the-significant-burden-of-febrile-nonhemolytic-transfusion-reactions
#20
Robert Cohen, Alioska Escorcia, Farzana Tasmin, Ana Lima, Yulia Lin, Lani Lieberman, Jacob Pendergrast, Jeannie Callum, Christine Cserti-Gazdewich
BACKGROUND: Febrile nonhemolytic transfusion reactions (FNHTRs) are characterized by a post-transfusion temperature rise (of ≥ 1°C, to ≥ 38°C) or chills/rigors unrelated to the underlying condition. FNHTRs are provoked by inflammatory cytokines in the product or by host antileukocyte antibodies against residual donor leukocytes. FNHTRs are among the most commonly reported transfusion disturbances and are generally deemed nonserious events. However, their impact on patients and hospitals may be underestimated...
March 28, 2017: Transfusion
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