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https://www.readbyqxmd.com/read/29458216/institution-of-a-comprehensive-postpartum-hemorrhage-bundle-at-a-large-academic-center-does-not-immediately-reduce-maternal-morbidity
#1
Rebecca Feldman Hamm, Eileen Wang, Kathleen O'Rourke, April Romanos, Sindhu K Srinivas
OBJECTIVE: Obstetric hemorrhage is a leading cause of morbidity and mortality. We sought to assess whether institution of a postpartum hemorrhage (PPH) bundle could improve maternal morbidity in our population. STUDY DESIGN: Preintervention data (PRE) was collected on all deliveries at Hospital of the University of Pennsylvania between October 15, 2013 and December 15, 2013. A two-pronged, multidisciplinary educational and procedural intervention related to PPH was instituted from March 2015 to June 2015...
February 19, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29458212/programmed-drug-delivery-system-based-on-optimized-size-decrease-and-hydrophilicity-hydrophobicity-transformation-for-enhanced-hepatocellular-carcinoma-therapy-of-doxorubicin
#2
Yuanyuan Liu, Lian Li, Lijia Li, Zhou Zhou, Fengling Wang, Xiaofeng Xiong, Rui Zhou, Yuan Huang
Requirements on drug delivery systems to surmount a complex series of pathophysiological barriers bear "cascading contradictions", especially size and hydrophilicity/hydrophobicity contradiction. Herein, a programmed drug delivery system (GNPs-Dox-Lac) based on optimized "size decrease and hydrophilicity/hydrophobicity transformation" was developed by combination the gelatin nanoparticle (GNPs) and prodrug Doxorubicin-Lactose (Dox-Lac). The results showed that GNPs-Dox-Lac (133.3 nm) were kinetically stable in blood circulation and inclined to accumulate at the tumor site...
February 16, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29458194/differential-effects-of-acute-versus-chronic-stress-on-ethanol-sensitivity-evidence-for-interactions-on-both-behavioral-and-neuroimmune-outcomes
#3
Tamara L Doremus-Fitzwater, Jacqueline E Paniccia, Anny Gano, Andrew Vore, Terrence Deak
Acute alcohol intoxication induces significant alterations in brain cytokines. Since stress challenges also profoundly impact central cytokine expression, these experiments examined the influence of acute and chronic stress on ethanol-induced brain cytokine responses. In Experiment 1, adult male rats were exposed to acute footshock. After a post-stress recovery interval of 0, 2, 4, or 24 h, rats were administered ethanol (4 g/kg; intragastric), with trunk blood and brains collected 3 h later. In non-stressed controls, acute ethanol increased expression of Il-6 and IκBα in the hippocampus...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29458135/porcine-heart-interatrial-septum-anatomy
#4
Mateusz K Hołda, Mateusz Koziej, Katarzyna Piątek, Wiesława Klimek-Piotrowska
BACKGROUND: The left-sided atrial septal pouch (SP), a recently re-discovered anatomical structure within the human interatrial septum, has emerged as a possible source of thrombi formation and a trigger for atrial fibrillation, thereby potentially increasing the risk for ischemic stroke. In many studies, the swine interatrial septum has been used as model of the human heart. Also, possible new strategies and devices for management of the SPs may first be tested in this pig model. Therefore, in this study, we aimed to evaluate swine interatrial septum morphology and to compare it with the human analog, especially in the light of SP occurrence...
February 16, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29458085/the-effect-of-surface-charge-and-ph-on-the-physiological-behaviour-of-cobalt-copper-manganese-antimony-zinc-and-titanium-oxide-nanoparticles-in-vitro
#5
Tiina Titma
The precise knowledge on various interactions of metal nanoparticles (NP) in a living organism is scarce. It is expected that metals can bind to nucleic acids, peptides and proteins (e.g. enzymes), and modify the functioning of vital cellular compartments after entering the organism. The predictive factors for quantitative nanostructure-activity relationship (QNAR) analysis could enhance efficient and harmless usage of nanoparticles (NPs) in the industry as well in the medicine. The studies value the composition of the NP corona determined by time, temperature and source of protein which has been found to implicate the physiological behaviour of NPs...
February 16, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29458044/cryoprotective-effect-of-antifreeze-polyamino-acid-carboxylated-poly-l-lysine-on-bovine-sperm-a-technical-note
#6
Takuro Fujikawa, Shuji Imamura, Motoyuki Tokumaru, Takaaki Ando, Yuki Gen, Suong-Hyu Hyon, Chikara Kubota
In this study, investigating Carboxylated Poly-L-Lysine (CPLL) for its effectiveness as a new cryoprotectant for bovine sperm is aimed. CPLL is an ampholytic polymer compound, has cryoprotective properties similar to those of anti-freeze protein. The cryopreservation medium used for control group consisted of 6.5% (v/v) glycerol, the cryopreservation medium used for experimental group consisted of 3.25% (v/v) glycerol + 0.5% (w/v) CPLL. There was no consequential difference in sperm motility parameter after thawing whereas there was huge distinction for sperm membrane integrity rate (control vs experimental; 49...
February 16, 2018: Cryobiology
https://www.readbyqxmd.com/read/29457919/enterobacteriaceae-antibiotic-resistance-in-ready-to-eat-foods-collected-from-hospital-and-community-canteens-analysis-of-prevalence
#7
Sara Vincenti, Matteo Raponi, Romina Sezzatini, Gabriele Giubbini, Patrizia Laurenti
Foodborne diseases and antibiotic resistance are serious widespread health problems in the contemporary world. In this study, we compared the microbiological quality of ready-to-eat (RTE) foods found in community canteens versus hospital canteens in Rome, Italy, focusing on detection and quantification of Enterobacteriaceae and the antibiotic resistance of these bacteria. Our findings show a remarkable difference in Enterobacteriaceae contamination between RTE foods distributed in community canteens (33.5% of samples) and those distributed in hospital canteens (5...
February 19, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29457900/three-dimensional-structures-based-on-the-fusion-of-chrysene-and-spirobifluorene-chromophores-for-the-development-of-blue-oleds
#8
Hayoon Lee, Hyocheol Jung, Seokwoo Kang, Jin Hyuck Heo, Sang Hyuk Im, Jongwook Park
A new deep-blue chromophore containing a three-dimensionally (3D) shaped CS core composed of fused chrysene and spirofluorene units is synthesized. A pair of m-terphenyl (TP) units is also substituted onto the CS core, at two different sets of positions to form two additional compounds: CS-TPTP and TP-CS-TP. The TP-CS-TP compound showed the highest efficiency with an external quantum efficiency (EQE) of 3.05%, and Commission Internationale de L'Eclairage coordinates (CIE) of (0.148, 0.098) corresponding to the emission of blue light...
February 19, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29457894/small-molecule-allosteric-modulators-of-g-protein-coupled-receptors-drug-target-interactions
#9
Shaoyong Lu, Jian Zhang
G-protein-coupled receptors (GPCRs) are the largest class of signaling receptors that are most frequently targeted by therapeutic drugs. Allosteric modulators bound to GPCRs at allosteric sites provide the potential for differential selectivity and improved safety compared with traditional orthosteric ligands. The recent breakthroughs in GPCR structural biology have made structures of GPCRs from classes A, B, C, and F complexed with small-molecule allosteric modulators available. Knowledge on the detailed receptor-modulator interactions at the allosteric sites is useful for structure-based GPCR drug design of novel therapeutics...
February 19, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29457810/a-computational-study-of-the-catalytic-aerobic-epoxidation-of-propylene-over-the-coordinatively-unsaturated-metal-organic-framework-fe-3-btc-2-formation-of-propylene-oxide-and-competing-reactions
#10
Thana Maihom, Montree Sawangphruk, Michael Probst, Jumras Limtrakul
The aerobic epoxidation of propylene over the metal-organic framework Fe3 (btc)2 (btc = 1,3,5-benzentricarboxylate) as catalyst has been investigated by means of density functional calculations. The mechanisms of the reaction towards propylene oxide, carbonylic products (acetone and propanal) and a pi-allyl radical were investigated to assess the efficiency of Fe3 (btc)2 for the selective formation of propylene oxide. Propylene oxide and carbonylic products are formed on Fe3 (btc)2 by proceeding via propyleneoxy intermediates in the first step...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29457809/domain-size-polydispersity-effects-on-the-structural-and-dynamical-properties-in-lipid-monolayers-with-phase-coexistence
#11
Elena Rufeil-Fiori, Adolfo J Banchio
In lipid monolayers with phase coexistence, domains of the liquid-condensed phase always present size polydispersity. However, very few theoretical works consider size distribution effects on the monolayer properties. Because of the difference in surface densities, domains have excess dipolar density with respect to the surrounding liquid expanded phase, originating a dipolar inter-domain interaction. This interaction depends on the domain area, and hence the presence of a domain size distribution is associated with interaction polydispersity...
February 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29457668/the-relationships-between-depression-neuroticism-and-attitudes-nda-model-in-heroin-abusers-in-taiwan
#12
Kun-Hua Lee, Cheng-Fang Yen
BACKGROUND AND OBJECTIVES: Heroin use is a severe problem worldwide. To develop more effective treatments for heroin abusers, a comprehensive psychosocial model of heroin use should be established and examined. We created and assessed a neuroticism, depression, attitudes, and heroin addiction (NDA) model. METHODS: In this cross-sectional study, 234 patients undergoing methadone replacement treatment were recruited from psychiatric clinics. We used Structural Equation Modeling (SEM) to assess all for neuroticism, depression, and a positive outcome expectancy (POE) (attitudes)...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29457640/application-of-adaptive-laboratory-evolution-to-overcome-a-flux-limitation-in-an-escherichia-coli-production-strain
#13
Kento Tokuyama, Yoshihiro Toya, Takaaki Horinouchi, Chikara Furusawa, Fumio Matsuda, Hiroshi Shimizu
Gene deletion strategies using flux balance analysis (FBA) have improved the growth-coupled production of various compounds. However, the productivities were often below the expectation because the cells failed to adapt to these genetic perturbations. Here, we demonstrate the productivity of the succinate of the designed gene deletion strain was improved by adaptive laboratory evolution (ALE). Although FBA predicted deletions of adhE-pykAF-gldA-pflB lead to produce succinate from glycerol with a yield of 0...
February 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29457631/non-invasive-genetic-censusing-and-monitoring-of-primate-populations
#14
REVIEW
Mimi Arandjelovic, Linda Vigilant
Knowing the density or abundance of primate populations is essential for their conservation management and contextualizing socio-demographic and behavioral observations. When direct counts of animals are not possible, genetic analysis of non-invasive samples collected from wildlife populations allows estimates of population size with higher accuracy and precision than is possible using indirect signs. Furthermore, in contrast to traditional indirect survey methods, prolonged or periodic genetic sampling across months or years enables inference of group membership, movement, dynamics, and some kin relationships...
February 19, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29457592/pegylated-graphene-oxide-fe3o4-nanocomposite-synthesis-characterization-and-evaluation-of-its-performance-as-de-novo-drug-delivery-nanosystem
#15
Abbas Jafarizad, Ali Taghizadehgh-Alehjougi, Morteza Eskandani, Maryam Hatamzadeh, Mojtaba Abbasian, Rahim Mohammad-Rezaei, Maryam Mohammadzadeh, Başak Toğar, Mehdi Jaymand
This paper describes the development of mitoxantrone-loaded PEGylated graphene oxide/magnetite nanoparticles (PEG-GO/Fe3O4-MTX), and investigation of its preliminary drug delivery performance. For this, the GO was synthesized through oxidizing graphite powder, and subsequently carboxylated using a substitution nucleophilic reaction. The carboxylated GO (GO-COOH) was then conjugated with amine end-caped PEG chains by Steglich esterification. Afterward, GO-PEG/Fe3O4 nanocomposite was synthesized through the anchoring of Fe3O4 nanoparticles onto the surface of GO-PEG during the sonication...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29457575/testing-the-effect-of-an-arbitrary-subject-pronoun-on-relative-clause-comprehension-a-study-with-hebrew-speaking-children
#16
Yair Haendler, Flavia Adani
Previous studies have found that Hebrew-speaking children accurately comprehend object relatives (OR) with an embedded non-referential arbitrary subject pronoun (ASP). The facilitation of ORs with embedded pronouns is expected both from a discourse-pragmatics perspective and within a syntax-based locality approach. However, the specific effect of ASP might also be driven by a mismatch in grammatical features between the head noun and the pronoun, or by its relatively undemanding referential properties. We tested these possibilities by comparing ORs whose embedded subject is either ASP, a referential pronoun, or a lexical noun phrase...
February 19, 2018: Journal of Child Language
https://www.readbyqxmd.com/read/29457416/-meta-analysis-of-the-efficacy-and-safety-of-pfna-and-intertan-for-the-treatment-of-intertrochanteric-fractures
#17
Jun-Jun Shi, Yu-Ze Wang, Yuan Li, Yuan-Peng Gao, Dong Wang, Zhi-Yong Wang, Zhi-Qiang Zhang
OBJECTIVE: To system evaluate the clinical effect and safety of PFNA and InterTAN internal fixation methods for femoral intertrochanteric fracture. METHODS: According to the Cochrane systemic analysis method, randomized controlled trials and quasi-randomized controlled trials which were about the comparison of PFNA and InterTAN for intertrochanteric fracture were collected from Cochrane Library(2017, issue 4), PubMed (January, 2003-May, 2017), Wanfang Med Online (January, 2003-May, 2017) and China Academic Journals Full-text Database(January, 2003-May, 2017) by computer searching...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457385/-current-status-and-expectations-in-the-surgical-treatment-of-recurrent-lateral-patellar-dislocation
#18
Zhi-Dong Zhao, Peng-Cui Li, Xiao-Chun Wei
Up to now, surgical treatment of recurrent lateral patellar dislocation mainly includes: medial patellofemoral ligament reconstruction, tibial tubercle osteotomy, trochleoplasty, lateral retinacular release, derotation osteotomy and so on . Clinical reports show that: the use of a single or combined with several methods have achieved ideal short to mid-term clinical outcomes. However, there is no consolidate criterion concerning the choices of different kinds of surgical ways for the treatment of individual recurrent lateral patellar dislocation...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457358/crt-survey-ii-a-european-society-of-cardiology-survey-of-cardiac-resynchronisation-therapy-in-11-088-patients-who-is-doing-what-to-whom-and-how
#19
Kenneth Dickstein, Camilla Normand, Angelo Auricchio, Nigussie Bogale, John G Cleland, Anselm K Gitt, Christoph Stellbrink, Stefan D Anker, Gerasimos Filippatos, Maurizio Gasparini, Gerhard Hindricks, Carina Blomström Lundqvist, Piotr Ponikowski, Frank Ruschitzka, Giovanni Luca Botto, Alan Bulava, Gabor Duray, Carsten Israel, Christophe Leclercq, Peter Margitfalvi, Óscar Cano, Chris Plummer, Nedim Umutay Sarigul, Maciej Sterlinski, Cecilia Linde
BACKGROUND: Cardiac resynchronisation therapy (CRT) reduces morbidity and mortality in appropriately selected patients with heart failure and is strongly recommended for such patients by guidelines. A European Society of Cardiology (ESC) CRT survey conducted in 2008-2009 showed considerable variation in guideline adherence and large individual, national and regional differences in patient selection, implantation practice and follow-up. Accordingly, two ESC associations, the European Heart Rhythm Association and the Heart Failure Association, designed a second prospective survey to describe contemporary clinical practice regarding CRT...
February 19, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29457354/nitrogen-enriched-carbon-cnt-composites-based-on-schiff-base-networks-ultrahigh-n-content-and-enhanced-lithium-storage-properties
#20
Zhichang Xiao, Qi Song, Ruiying Guo, Debin Kong, Shanke Zhou, Xiaoxiong Huang, Rashid Iqbal, Linjie Zhi
To improve the electrochemical performance of carbonaceous anodes for lithium ion batteries (LIBs), the incorporation of both well-defined heteroatom species and the controllable 3D porous networks are urgently required. In this work, a novel N-enriched carbon/carbon nanotube composite (NEC/CNT) through a chemically induced precursor-controlled pyrolysis approach is developed. Instead of conventional N-containing sources or precursors, Schiff-base network (SNW-1) enables the desirable combination of a 3D polymer with intrinsic microporosity and ultrahigh N-content, which can significantly promote the fast transport of both Li+ and electron...
February 19, 2018: Small
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