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https://www.readbyqxmd.com/read/28551930/-laboratory-tests-and-radiological-imaging-diagnostic-tools-that-share-information-and-can-be-functionally-integrated
#1
Michael Mayer
In spite of apparent disparity between the specialties of radiological imaging, pathology and laboratory analysis, the medical diagnostic information that these sources provide have a lot in common and can be effectively utilized by sharing quantitative and qualitative results through modern information technology processes. Informaticsbased integration of radiological imaging, digital images of anatomical and molecular pathology and clinical laboratory results enables earlier, more sensitive and precise diagnosis, resulting in the more efficient treatment of patients...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551929/-early-in-hospital-mortality-in-internal-medicine-wards-within-24-hours-a-potential-quality-indicator-or-a-variable-affected-by-multiple-factors
#2
Yaron Niv, Evgeny Berkov, Pazit Kanter, Evgeny Abrahmson, Uri Gabbay
AIMS: To evaluate in-hospital mortality rate within 24 hours in internal medicine wards and to evaluate if it may be used as quality indicator. BACKGROUND: In-hospital mortality rate is an outcome measure which apparently reflects quality of care. There are debates on whether it may be considered a quality indicator since it is difficult to compare different case-mixes between hospitals. Research on mortality within 24 hours had not been published. METHODS: An historical prospective study was conducted including the entire internal wards admissions to the Rabin Medical Center between 1/7/14 and 30/6/15...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551859/cognitive-workload-reduction-in-hospital-information-systems-decision-support-for-order-set-optimization
#3
Daniel Gartner, Yiye Zhang, Rema Padman
Order sets are a critical component in hospital information systems that are expected to substantially reduce physicians' physical and cognitive workload and improve patient safety. Order sets represent time interval-clustered order items, such as medications prescribed at hospital admission, that are administered to patients during their hospital stay. In this paper, we develop a mathematical programming model and an exact and a heuristic solution procedure with the objective of minimizing physicians' cognitive workload associated with prescribing order sets...
May 27, 2017: Health Care Management Science
https://www.readbyqxmd.com/read/28551854/tuning-and-elucidation-of-the-colony-dimorphism-in-rhodococcus-ruber-associated-with-cell-flocculation-in-large-scale-fermentation
#4
Song Jiao, Jie Chen, Huimin Yu, Zhongyao Shen
Prevention of cell flocculation in large-scale fermentation is of great importance for most industrial microbes. Using Rhodococcus ruber TH3 as a model strain, we revealed that the undesired cell flocculation in a fermenter was associated with the colony dimorphism phenomenon, and it only occurred in the rough-type of cells (R-TH3) instead of the smooth-type of cells (S-TH3). By analyzing the transcriptome differences of R-TH3 and S-TH3, six representative genes with significantly upregulated transcription in S-TH3 were selected and overexpressed in R-TH3...
May 27, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28551825/necroptosis-and-ferroptosis-are-alternative-cell-death-pathways-that-operate-in-acute-kidney-failure
#5
Tammo Müller, Christin Dewitz, Jessica Schmitz, Anna Sophia Schröder, Jan Hinrich Bräsen, Brent R Stockwell, James M Murphy, Ulrich Kunzendorf, Stefan Krautwald
Ferroptosis is a recently recognized caspase-independent form of regulated cell death that is characterized by the accumulation of lethal lipid ROS produced through iron-dependent lipid peroxidation. Considering that regulation of fatty acid metabolism is responsible for the membrane-resident pool of oxidizable fatty acids that undergo lipid peroxidation in ferroptotic processes, we examined the contribution of the key fatty acid metabolism enzyme, acyl-CoA synthetase long-chain family member 4 (ACSL4), in regulating ferroptosis...
May 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28551713/atomoxetine-effects-on-attentional-bias-to-drug-related-cues-in-cocaine-dependent-individuals
#6
Luca Passamonti, M Luijten, H Ziauddeen, I T S Coyle-Gilchrist, T Rittman, S A E Brain, R Regenthal, I H A Franken, B J Sahakian, E T Bullmore, T W Robbins, K D Ersche
RATIONALE: Biased attention towards drug-related cues and reduced inhibitory control over the regulation of drug-intake characterize drug addiction. The noradrenaline system has been critically implicated in both attentional and response inhibitory processes and is directly affected by drugs such as cocaine. OBJECTIVES: We examined the potentially beneficial effects of the noradrenaline reuptake inhibitor atomoxetine in improving cognitive control during two tasks that used cocaine- and non-cocaine-related stimuli...
May 27, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28551537/the-effects-of-non-native-signal-crayfish-pacifastacus-leniusculus-on-fine-sediment-and-sediment-biomonitoring
#7
Matt D Turley, Gary S Bilotta, Antonio Gasparrini, Francesco Sera, Kate L Mathers, Ian Humpheryes, Judy England
The North American signal crayfish (Pacifastacus leniusculus) has invaded freshwater ecosystems across Europe. Recent studies suggest that predation of macroinvertebrates by signal crayfish can affect the performance of freshwater biomonitoring tools used to assess causes of ecological degradation. Given the reliance on biomonitoring globally, it is crucial that the potential influence of invasive species is better understood. Crayfish are also biogeomorphic agents, and therefore, the aim of this study was to investigate whether sediment-biomonitoring tool outputs changed following signal crayfish invasions, and whether these changes reflected post-invasion changes to deposited fine sediment, or changes to macroinvertebrate community compositions unrelated to fine sediment...
May 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28551519/effect-of-binary-solid-lipid-matrix-of-wax-and-triglyceride-on-lipid-crystallinity-drug-lipid-interaction-and-drug-release-of-ibuprofen-loaded-solid-lipid-nanoparticles-sln-for-dermal-delivery
#8
Thitirat Chantaburanan, Veerawat Teeranachaideekul, Doungdaw Chantasart, Anchalee Jintapattanakit, Varaporn Buraphacheep Junyaprasert
HYPOTHESIS: The physicochemical properties of solid lipid nanoparticles (SLN) depend on lipid compositions. An addition of secondary solid complex triglycerides (Softisan 378; S378) into solid wax (cetyl palmitate; CP) is expected to influence the properties of obtained SLN compared to SLN prepared from sole CP. EXPERIMENTS: Ibuprofen-loaded SLN (IBSLN-TG) composed of different ratios of CP and S378 were prepared and evaluated in term of size, zeta potential (ZP), entrapment efficiency (E...
May 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28551478/predictors-of-occupational-stress-and-well-being-in-first-line-nurse-managers-a-cross-sectional-survey-study
#9
Jef Adriaenssens, Ambre Hamelink, Peter Van Bogaert
BACKGROUND: First-line nurse managers have a pivotal role in the organization of health care but have to deal with significant job-related issues and problems in a changing and challenging health care environment. As their new roles are complex and often unclear, it might be expected that these professionals are at risk for occupational stress. OBJECTIVES: The objective of this study is to analyze and describe relationships between job characteristics, and also interdisciplinary conflicts with physicians as potential predictors of occupational well-being (job satisfaction, psychosomatic distress, turnover intention, work engagement and burnout)...
May 12, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28551444/effect-of-prior-focal-therapy-on-perioperative-oncologic-and-functional-outcomes-of-salvage-robotic-assisted-radical-prostatectomy
#10
Igor Nunes-Silva, Eric Barret, Victor Srougi, Mohammed Baghdadi, Paolo Capogrosso, Silvia Garcia-Barreras, Solange Kanso, Rafael Tourinho-Barbosa, Ariê Carneiro, Rafael Sanchez-Salas, François Rozet, Marc Galiano, Xavier Cathelineau
PURPOSE: To assess the impact of focal therapy (FT) on perioperative, oncologic, and functional outcomes in men who underwent salvage robotic-assisted radical prostatectomy(S-RARP) compared to primary RARP (P-RARP). MATERIALS AND METHODS: FT was performed in patients presenting Gleason score 3+3 or 3+4, clinical stage ≤cT2a, serum prostate-specific antigen(PSA) ≤15ng/ml, unilateral positive biopsy, maximum length of any positive core <10mm and life expectancy >10 years...
May 24, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28551401/imaging-workup-of-suspected-classical-paraneoplastic-neurological-syndromes-a-systematic-review-and-retrospective-analysis-of-18-f-fdg-pet-ct
#11
Benedikt Sundermann, Jens-Burchard Schröder, Tobias Warnecke, Walter Heindel, Michael Schäfers, Matthias Weckesser, Boris Buerke
RATIONALE AND OBJECTIVES: This study aimed to assess the clinical efficacy of positron emission tomography (PET) or combined PET-computed tomography (CT) with (18)F-fluorodeoxyglucose (FDG) for whole-body cancer screening in patients with suspected paraneoplastic neurological syndromes (PNS). The following main research questions were addressed: What is the percentage of positive findings to be expected in whole-body FDG-PET-CT in adult patients with PNS? How many false positives can be expected as assessed by clinical and histopathological workup? Are there patients who present with a tumor despite initially negative findings? MATERIALS AND METHODS: This is a systematic review of the literature and retrospective analysis of FDG-PET-CT and clinical follow-up data from 45 consecutive patients (age: 56...
May 24, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28551375/cytoskeletal-organization-in-microtentacles
#12
Alison N Killilea, Roseann Csencsits, Emily Le, Anand M Patel, Samuel J Kenny, Ke Xu, Kenneth H Downing
Microtentacles are thin, flexible cell protrusions that have recently been described and whose presence enhances efficient attachment of circulating cells. They are found on circulating tumor cells and can be induced on a wide range of breast cancer cell lines, where they are promoted by factors that either stabilize microtubules or destabilize the actin cytoskeleton. Evidence suggests that they are relevant to the metastatic spread of cancer, so understanding their structure and formation may lead to useful therapies...
May 24, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28551286/flexural-limb-deformities-of-the-carpus-and-fetlock-in-foals
#13
REVIEW
Earl M Gaughan
Early recognition and treatment of congenital and acquired flexural deformities of the carpi and fetlocks of foals can lead to conformation correction and an athletic future. Treatment is often based on rigid external coaptation assisted by systemic medical treatment. Foals that readily respond to treatment and correct conformation faults can have normal adult athletic expectations.
May 25, 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/28551194/effects-of-shortening-the-close-up-period-length-coupled-with-increased-supply-of-metabolizable-protein-on-performance-and-metabolic-status-of-multiparous-holstein-cows
#14
T Amirabadi Farahani, H Amanlou, M Kazemi-Bonchenari
This experiment was conducted to compare conventional (CON; 21 d) and shortened (SH; 10 d) close-up period, and evaluate the effect of shortened close-up period combined with feeding different metabolizable protein (MP) levels on dry matter (DM) intake, metabolic status, and performance of dairy cows. Forty-eight multiparous Holstein cows with similar parity, body weight (BW), and previous lactation milk yield were divided into 2 groups. The first group (n = 24) received the far-off diet from -60 to -21 d (CON), and the second group (n = 24) received same far-off diet from -60 to -10 d (SH) relative to expected parturition...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28551192/differences-in-liver-functionality-indexes-in-peripartal-dairy-cows-fed-rumen-protected-methionine-or-choline-are-associated-with-performance-oxidative-stress-status-and-plasma-amino-acid-profiles
#15
Z Zhou, E Trevisi, D N Luchini, J J Loor
The liver functionality index (LFI) represents an assessment of transition cow metabolic health by measuring changes in biomarkers associated with liver plasma protein synthesis (albumin), lipoprotein synthesis (cholesterol), and heme catabolism (bilirubin). The present analysis was conducted to determine the role of peripartal rumen-protected Met or choline (CHOL) supplementation on LFI groupings, and to assess relationships with performance, inflammation, oxidative stress status, and plasma AA profiles. A cohort of 40 multiparous Holstein cows that were part of a randomized complete block design with 2 × 2 factorial arrangement of Met (Smartamine M, Adisseo NA, Alpharetta, GA) and CHOL (ReaShure, Balchem Inc...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28551133/enzyme-free-chemiluminescence-immunoassay-for-the-determination-of-thyroid-stimulating-hormone
#16
Chaeyoon Shim, Richard Chong, Ji Hoon Lee
Based on the chemiluminescent resonance energy transfer (CRET) from high-energy intermediate formed in 1,1'-oxalyldiimidazole chemiluminescence (ODI-CL) reaction to fluorescent microsphere-conjugated detection antibody, a cost-effective and highly sensitive enzyme-free sandwich immunoassay with chemiluminescence detection was developed for the early diagnosis of thyroid cancer. Thyroid stimulating hormone (TSH) primary antibody immobilized on paramagnetic bead captures rapidly TSH in human serum within 15min...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28551123/l-noradrenaline-functionalized-near-infrared-fluorescence-cdsete-probe-for-the-determination-of-urea-and-bioimaging-of-hepg2-cells
#17
Zhenzhen Li, Qiyi Zhang, Huaying Huang, Changjing Ren, Si Ouyang, Qiang Zhao
In this paper, near-infrared (NIR) light emitting L-noradrenaline functionalized CdSeTe QDs (NA-CdSeTe) were synthesized and applied to the biosensing of urea. When the pH value of NA-CdSeTe solution was adjusted from neutral to alkalinity, the noradrenaline on the surface of QDs would turn to quinone, which triggered the fluorescence quenching of NA-CdSeTe probe due to the charge transfer interactions between QDs and the proximal quinone. Based on the fact that the hydrolysis of urea in the presence of urease would release OH(-) and slightly change the pH value of the solution, the fluorescence intensity of NA-CdSeTe QDs could be linked to the enzymatic degradation of urea...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28551097/how-to-best-support-sit-to-stand-transfers-of-geriatric-patients-motion-optimization-under-external-forces-for-the-design-of-physical-assistive-devices
#18
Katja Mombaur, Khai-Long Ho Hoang
Sit to stand (STS) transfers form a challenging type of motion, in particular for geriatric patients. Physical assistive devices that are built to enhance the mobility of this class of patients therefore must especially be able to support STS transfers. This paper presents a method to predict geriatric STS movements and compute the best possible actions by external devices to support these movements. We treat three types of active devices that act on different parts of the patient's body and provide different levels of support...
May 17, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28551035/examining-the-role-of-patient-values-in-decisions-about-long-term-enteral-feeding-a-qualitative-study
#19
Sean White, Louise Brereton
BACKGROUND & AIMS: Although studies demonstrate the range of impacts of home enteral feeding (HEF) on patients' lives, a dearth of evidence focussing on the decision to have a gastrostomy placed exists. The importance of taking account of patient values (i.e. their unique preferences, concerns and expectations) when considering the consequences of clinical decisions is increasingly recognised. This study explores patient's views on the role of their values in their decision to have a gastrostomy...
May 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28551002/development-of-a-computer-interpretable-clinical-guideline-model-for-decision-support-in-the-differential-diagnosis-of-hyponatremia
#20
Arturo González-Ferrer, M Ángel Valcárcel, Martín Cuesta, Joan Cháfer, Isabelle Runkle
INTRODUCTION: Hyponatremia is the most common type of electrolyte imbalance, occurring when serum sodium is below threshold levels, typically 135mmol/L. Electrolyte balance has been identified as one of the most challenging subjects for medical students, but also as one of the most relevant areas to learn about according to physicians and researchers. We present a computer-interpretable guideline (CIG) model that will be used for medical training to learn how to improve the diagnosis of hyponatremia applying an expert consensus document (ECDs)...
July 2017: International Journal of Medical Informatics
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