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https://www.readbyqxmd.com/read/28454482/effects-of-environmental-factors-and-metallic-electrodes-on-ac-electrical-conduction-through-dna-molecule
#1
S Abdalla, A Obaid, F M Al-Marzouki
BACKGROUND: Deoxyribonucleic acid (DNA) is one of the best candidate materials for various device applications such as in electrodes for rechargeable batteries, biosensors, molecular electronics, medical- and biomedical-applications etc. Hence, it is worthwhile to examine the mechanism of charge transport in the DNA molecule, however, still a question without a clear answer is DNA a molecular conducting material (wire), semiconductor, or insulator? The answer, after the published data, is still ambiguous without any confirmed and clear scientific answer...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454383/fam53b-truncation-caused-by-t-10-19-q26-q13-chromosome-translocation-in-acute-lymphoblastic-leukemia
#2
Ioannis Panagopoulos, Ludmila Gorunova, Synne Torkildsen, Anne Tierens, Sverre Heim, Francesca Micci
RNA-sequencing of the patient's bone marrow detected fusion transcripts in which the coding sequence of the FAM53B gene (from 10q26) was fused to a genomic sequence (from 19q13) that mapped upstream of the SLC7A10 locus. Reverse transcription-polymerase chain reaction together with Sanger sequencing verified the presence of this fusion transcript. The FAM53B fusion transcript is not expected to produce any chimeric protein. However, it may code for a truncated FAM53B protein consisting of the first 302 amino acids of FAM53B together with amino acids from the 19q13 sequence...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454353/prmt8-demonstrates-variant-specific-expression-in-cancer-cells-and-correlates-with-patient-survival-in-breast-ovarian-and-gastric-cancer
#3
Sarah J Hernandez, David M Dolivo, Tanja Dominko
Recent emphasis has been placed on the role of epigenetic regulators and epigenetic marks as biomarkers for cancer diagnosis and prognosis, and as therapeutic targets for treatment. One such class of regulators is the protein arginine methyltransferase (PRMT) family. The present study examined available curated data regarding the expression and alteration of one of the least studied PRMT family members, PRMT8, in various types of cancer and cancer cell lines. Publicly available cancer data on PRMT8 expression were examined using the Human Protein Atlas and the Kaplan-Meier Plotter, and reverse transcription-polymerase chain reaction was used to screen a selection of human cell lines for variant-specific PRMT8 expression...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454195/-unicompartmental-vs-total-knee-arthroplasty-for-medial-osteoarthritis
#4
Tilman Pfitzner, Carsten Perka, Philipp von Roth
Background In end-stage medial osteoarthritis, the surgeon can decide whether to use unicompartmental or total knee arthroplasty for operative treatment of the patient. Despite the available literature there is a lack of evidence to suggest if one procedure can be rated as being superior to the other. With increasing demand for knee arthroplasty, treatment with the highest expectation of success will be of particular interest. The purpose of this manuscript was to analyse and compare the available literature on unicompartmental vs...
April 28, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28454163/image-recovery-from-defocused-2d-fluorescent-images-in-multimodal-digital-holographic-microscopy
#5
Xiangyu Quan, Osamu Matoba, Yasuhiro Awatsuji
A technique of three-dimensional (3D) intensity retrieval from defocused, two-dimensional (2D) fluorescent images in the multimodal digital holographic microscopy (DHM) is proposed. In the multimodal DHM, 3D phase and 2D fluorescence distributions are obtained simultaneously by an integrated system of an off-axis DHM and a conventional epifluorescence microscopy, respectively. This gives us more information of the target; however, defocused fluorescent images are observed due to the short depth of field. In this Letter, we propose a method to recover the defocused images based on the phase compensation and backpropagation from the defocused plane to the focused plane using the distance information that is obtained from a 3D phase distribution...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454160/spectral-selectivity-in-optical-fiber-capillary-dye-lasers
#6
Esmaeil Mobini, Behnam Abaie, Mostafa Peysokhan, Arash Mafi
We explore the spectral properties of a capillary dye laser in the highly multimode regime. Our experiments indicate that the spectral behavior of the laser does not conform to a simple Fabry-Perot (FP) analysis; rather, it is strongly dictated by a Vernier resonant mechanism involving multiple modes, which propagate with different group velocities. The laser operates over a very broad spectral range and the Vernier effect gives rise to a free spectral range, which is orders of magnitude larger than that expected from a simple FP mechanism...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454135/fiber-surface-bragg-grating-waveguide-for-refractive-index-measurements
#7
Chupao Lin, Changrui Liao, Jia Wang, Jun He, Ying Wang, Zhengyong Li, Tianhang Yang, Feng Zhu, Kaiming Yang, Zhe Zhang, Yiping Wang
A fiber surface Bragg grating waveguide (BGW) fabricated in the surface of single-mode fiber by direct femtosecond laser inscription is demonstrated and successfully applied for refractive index (RI) measurements. Prior to laser inscription of the fiber surface BGW, an X-coupler is first inscribed across the fiber core to couple light from the core to the fiber surface. The light transmitted in the fiber surface BGW efficiently interacts with the surrounding medium due to a strong evanescent field, and obtains an acceptable RI sensitivity approaching ∼16  nm/RIU...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454090/peroxiredoxin-6-overexpression-attenuates-lipopolysaccharide-induced-acute-kidney-injury
#8
Dong Hun Lee, Ju Ho Park, Sang Bae Han, Do Young Yoon, Yu Yeon Jung, Jin Tae Hong
Peroxiredoxin 6 (PRDX6) is a member of the PRDX family of antioxidant enzymes and correlated with inflammatory response. Therefore, we investigated the role of PRDX6 during lipopolysaccharide (LPS)-induced acute kidney injury. Both 3 months aged PRDX6-overexpressing transgenic mice (PRDX6 mice) and wild type (WT) mice had acute renal injury induced by intraperitoneal injection of LPS (10 mg/kg)., PRDX6 mice showed decreased mortality and renal injury following LPS challenge compared to WT mice. Furthermore, infiltration of macrophages, T-cells and neutrophils, and the number of apoptotic cells were more decreased by LPS treatment in PRDX6 mice than in WT mice...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28453975/synaptic-plasticity-in-dendrites-complications-and-coping-strategies
#9
REVIEW
Bartlett W Mel, Jackie Schiller, Panayiota Poirazi
The elaborate morphology, nonlinear membrane mechanisms and spatiotemporally varying synaptic activation patterns of dendrites complicate the expression, compartmentalization and modulation of synaptic plasticity. To grapple with this complexity, we start with the observation that neurons in different brain areas face markedly different learning problems, and dendrites of different neuron types contribute to the cell's input-output function in markedly different ways. By committing to specific assumptions regarding a neuron's learning problem and its input-output function, specific inferences can be drawn regarding the synaptic plasticity mechanisms and outcomes that we 'ought' to expect for that neuron...
April 25, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28453912/perceived-need-for-depression-treatment-among-persons-entering-inpatient-opioid-detoxification
#10
Michael D Stein, Olga J Santiago Rivera, Bradley J Anderson, Genie L Bailey
BACKGROUND AND OBJECTIVES: Depression is common among persons with opioid use disorder. We examined the perceived need for depression treatment (PNDT) among opioid-dependent patients and the relationship of PNDT to depression screening result. METHODS: Between May and December 2015, we surveyed consecutive persons (n = 440) seeking inpatient opioid detoxification. We used the Patient Health Questionnaire-2 (PHQ-2) to screen for depression. To assess perceived need for depression services, participants were asked, "Do you believe you should be treated for depression?" Response options were recorded into four categories: "Not Depressed (ND)," "Perceive Need for Depression Treatment (PNDT)," "Depressed/Don't Want Treatment," and "Currently Treated...
April 28, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28453882/the-validity-of-the-observed-to-expected-lung-to-head-ratio-in-congenital-diaphragmatic-hernia-in-an-era-of-standardized-neonatal-treatment-a-multicenter-study
#11
Kitty G Snoek, Nina C J Peters, Joost van Rosmalen, Arno F J van Heijst, Alex J Eggink, Esther Sikkel, René M Wijnen, Hanneke IJsselstijn, Titia E Cohen-Overbeek, Dick Tibboel
OBJECTIVE: To assess the predictive value of observed-to-expected lung-to-head ratio (O/E LHR) for survival and chronic lung disease (CLD) in survivors of left-sided congenital diaphragmatic hernia (CDH) in an era of standardized neonatal treatment, and to evaluate the predictive value of the O/E LHR trajectory for survival. METHODS: This retrospective cohort study was performed in two high-volume CDH centers in the Netherlands in prenatally detected, isolated left-sided CDH patients born between 2008-2014...
April 28, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28453866/use-of-1-h-post-load-plasma-glucose-concentration-to-identify-individuals-at-high-risk-of-developing-type-2-diabetes
#12
R Jagannathan, M Bergman
In view of the increasing burden of Type 2 diabetes on healthcare systems, considerable attention has been focused on identifying and treating individuals at high risk of the disease. This has led to the designation of 'prediabetes or intermediary hyperglycaemia', describing a fasting, 2-h plasma glucose (PG) or HbA1c level above the so-called normal range, but below that defining diabetes. According to the International Diabetes Federation, 318 million adults aged 20-79 years had prediabetes in 2015, and this is expected to rise to 481 million by 2040 [1] ...
April 28, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28453790/does-the-law-on-compensation-for-research-related-injury-in-the-uk-australia-and-new-zealand-meet-ethical-requirements
#13
Joanna M Manning
Despite a consensus that society owes an ethical obligation to compensate for research-related injury, and that no-fault is the best ethical response, an assessment of the compensation arrangements in place in the UK, Australia and New Zealand shows that in general compensation arrangements fall below this ethical expectation. Most subjects rely on ex gratia payment or an unenforceable assurance of payment in the event of injury. It is also likely that, given significant deficiencies in participant information about compensation arrangements in place for trials recommended by the supervisory ethics agencies in each jurisdiction, subjects only find out about their financial exposure in the event of injury...
April 26, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28453758/training-programs-on-endoscopic-scoring-systems-for-inflammatory-bowel-disease-lead-to-a-significant-increase-in-interobserver-agreement-among-community-gastroenterologists
#14
Marco Daperno, Michele Comberlato, Fabrizio Bossa, Alessandro Armuzzi, Livia Biancone, Andrea G Bonanomi, Rocco Cosintino, Giovanni Lombardi, Roberto Mangiarotti, Alfredo Papa, Roberta Pica, Luca Grassano, Guido Pagana, Renata D'Incà, Ambrogio Orlando, Fernando Rizzello
Background and Aims: Endoscopic outcomes are increasingly used in clinical trials and in routine practice for inflammatory bowel disease [IBD] in order to reach more objective patient evaluations than possible using only clinical features. However, reproducibility of endoscopic scoring systems used to categorize endoscopic activity has been reported to be suboptimal. The aim of this study was to analyse the inter-rated agreement of non-dedicated gastroenterologists on IBD endoscopic scoring systems, and to explore the effects of a dedicated training programme on agreement...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28453756/malignancies-in-patients-with-inflammatory-bowel-disease-results-from-20-years-of-follow-up-in-the-ibsen-study
#15
Øistein Hovde, Marte Lie Høivik, Magne Henriksen, Inger Camilla Solberg, Milada Cvancarova Småstuen, Bjørn A Moum
Background and Aims: Whether patients with inflammatory bowel diseases [IBDs] have increased risk of developing cancer has been debated. The aims of the study were to determine the prevalence of intestinal/extraintestinal cancers in an IBD cohort 20 years after diagnosis and to assess whether these patients had an increased cancer-specific risk compared with a matched control population. Methods: Patients with ulcerative colitis [UC] and Crohn's disease [CD] diagnosed 1990-1993 have been prospectively followed up for 20 years...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28453688/edlib-a-c-c%C3%A2-library-for-fast-exact-sequence-alignment-using-edit-distance
#16
Martin Šošic, Mile Šikic
Summary: We present Edlib, an open-source C/C ++ library for exact pairwise sequence alignment using edit distance. We compare Edlib to other libraries and show that it is the fastest while not lacking in functionality and can also easily handle very large sequences. Being easy to use, flexible, fast and low on memory usage, we expect it to be easily adopted as a building block for future bioinformatics tools. Availability and Implementation: Source code, installation instructions and test data are freely available for download at https://github...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28453671/wright-fisher-exact-solver-wfes-scalable-analysis-of-population-genetic-models-without-simulation-or-diffusion-theory
#17
Ivan Krukov, Bianca de Sanctis, A P Jason de Koning
Motivation: The simplifying assumptions that are used widely in theoretical population genetics may not always be appropriate for empirical population genetics. General computational approaches that do not require the assumptions of classical theory are therefore quite desirable. One such general approach is provided by the theory of absorbing Markov chains, which can be used to obtain exact results by directly analyzing population genetic Markov models, such as the classic bi-allelic Wright-Fisher model...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28453630/the-effects-of-cpg-densities-around-transcription-start-sites-on-sex-biased-gene-expression-in-poecilia-reticulata
#18
Katsunori Tamagawa, Takashi Makino, Masakado Kawata
Since most genes are shared between females and males, DNA methylation is assumed to play a crucial role in sex-biased gene expression. DNA methylation exclusively occurs at CpG dinucleotides, and therefore, we would expect that CpG density around transcription start sites (TSSs) relate to sex-biased gene expression. Here we investigated the relationship between CpG densities around TSSs and the ratio of gene expression levels between sexes in the guppy (Poecilia reticulata), which displays remarkable sexual dimorphisms...
April 26, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28453570/contrasting-effects-of-heat-pulses-on-different-trophic-levels-an-experiment-with-a-herbivore-parasitoid-model-system
#19
Stijn J J Schreven, Enric Frago, Annemiek Stens, Peter W de Jong, Joop J A van Loon
Under predicted global climate change, species will be gradually exposed to warmer temperatures, and to a more variable climate including more intense and more frequent heatwaves. Increased climatic variability is expected to have different effects on species and ecosystems than gradual warming. A key challenge to predict the impact of climate change is to understand how temperature changes will affect species interactions. Herbivorous insects and their natural enemies belong to some of the largest groups of terrestrial animals, and thus they have a great impact on the functioning of ecosystems and on the services these ecosystems provide...
2017: PloS One
https://www.readbyqxmd.com/read/28453564/the-influence-of-climatic-variation-and-density-on-the-survival-of-an-insular-passerine-zosterops-lateralis
#20
Erik M Sandvig, Tim Coulson, Jiro Kikkawa, Sonya M Clegg
Understanding the influence of environmental factors on population dynamics is fundamental to many areas in biology. Survival is a key factor of population biology, as it is thought to be the predominant driver of growth in long-lived passerines, which can be influenced by both biotic and abiotic environmental conditions. We used mark-recapture methods and generalized linear mixed models to test the influence of density and climatic variation, measured at a regional and local scale (Southern Oscillation Index [SOI] and rainfall, respectively), on seasonal variation in survival rates of an insular population of Silvereyes (Zosterops lateralis chlorocephalus), during a 15-year study period, off the east coast of Australia...
2017: PloS One
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