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Lorna A Nisbet, Rafael Venson, Fiona M Wylie, Karen S Scott
NBOMes are a group of new psychoactive substances derived from phenethylamines. Recreational abuse is thought to have begun in 2010 and they are commonly associated with the "club drug" scene. They are administered in liquid form or as blotters due to their high potency. An LC-MS-MS method was validated using Scientific Working Group for Forensic Toxicology parameters for the detection of 25B-, 25C- and 4-iodo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine (25I-NBOMe) using 4-bromo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine (25B-NBOMe)-D3 as internal standard for urine and hair...
July 1, 2017: Journal of Analytical Toxicology
Weiwei Xie, Yiran Jin, Ludan Hou, Yinghua Ma, Huijun Xu, Kerong Zhang, Lantong Zhang, Yingfeng Du
Ponicidin is an active natural ent-kaurane diterpenoid ingredient originating from many Isondon herbs and is expected to become a new anticancer agent. In this study, a practical strategy was developed for the identification of ponicidin metabolites in vivo and in vitro utilizing ultra-high-performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS). The analytical strategy was as follows: potential ponicidin metabolites were detected by a novel on-line data acquisition approach, i...
August 11, 2017: Journal of Pharmaceutical and Biomedical Analysis
Trevon L Fuller, Paul R Sesink Clee, Kevin Y Njabo, Anthony Tróchez, Katy Morgan, Demetrio Bocuma Meñe, Nicola M Anthony, Mary Katherine Gonder, Walter R Allen, Rachid Hanna, Thomas B Smith
Although a number of recent studies suggest that climate associated shifts in agriculture are affecting social and economic systems, there have been relatively few studies of these effects in Africa. Such studies would be particularly useful in Central Africa, where the impacts of climate warming are predicted to be high but coincide with an area with low adaptive capacity. Focusing on plantain (Musa paradisiaca), we assess whether recent climate change has led to reduced yields. Analysis of annual temperature between 1950 and 2013 indicated a 0...
August 19, 2017: Science of the Total Environment
Fsf de Siqueira, Afm Cardenas, Y L Gruber, C Kose, Y M Pupo, G M Gomes, Omm Gomes, J C Gomes
The expectation of an esthetically harmonious smile increases the level of difficulty when treating patients. Laminate veneers stand out as a treatment option for cosmetic rehabilitation in clinical practice, as they are a more conservative procedure and mimic dental structures. These laminate veneers are generally made with different techniques; the most common requires an impression of the prepared tooth, an impression antagonist, fabrication models, and extensive laboratory time. The computer-aided design/computer-aided manufacturing (CAD/CAM) system optimizes the fabrication of prosthetic structures, reducing chairside time and promoting good esthetic results...
September 2017: Operative Dentistry
S Pupin, L N Rosse, I C G Souza, J Cambuim, C L Marino, M L T Moraes, A M Sebbenn
Eucalyptus urophylla is an important species in the Brazilian forest sector due to its rapid growth rates and resistance to disease. The aim of this study was to verify Mendelian inheritance, genetic linkage, and genotypic disequilibrium for 15 microsatellite loci, with the goal of producing a robust set of genetic markers. Mendelian inheritance and genetic linkage analyses were carried out using genotypes from maternal trees, and their open-pollinated seeds and genotypic disequilibrium were assessed using adult trees...
August 17, 2017: Genetics and Molecular Research: GMR
F F Chen, C Y Ma, L P Yan, H Zhang, W Wang, Y Zhang, L B Ma
In this study, 10 polymorphic microsatellite markers were developed in Scomber japonicus and were examined on 30 individuals collected from the North Pacific. The number of alleles per locus ranged from 4 to 17. The observed and expected heterozygosities per locus ranged from 0.2759 to 0.8621 and from 0.43071 to 0.9177, respectively. The polymorphism information content (PIC) was from 0.3931 to 0.8939. One locus showed moderate polymorphism (0.25 < PIC < 0.5), while the rest were highly polymorphic (PIC > 0...
August 17, 2017: Genetics and Molecular Research: GMR
R B Feitosa-Alcantara, A V C Silva, A F Blank, C S Almeida, S V Alvares-Carvalho, M F Arrigoni-Blank
Hyptis pectinata, popularly known as 'sambacaitá' or 'canudinho', is a medicinal and aromatic species widely used in the Brazilian Northeast. In Sergipe, the excessive extraction of natural resources may reduce the genetic variability of native plants. Thus, molecular markers have frequently been applied to the characterization of genetic diversity as the basis for germplasm conservation and breeding programs. The objective of the present study was to evaluate the genetic diversity of H. pectinata plants collected in different municipalities of the State of Sergipe using ISSR molecular markers...
August 17, 2017: Genetics and Molecular Research: GMR
Margrit Löbner, Janine Stein, Melanie Luppa, Alexander Konnopka, Hans Jörg Meisel, Lutz Günther, Jürgen Meixensberger, Katarina Stengler, Matthias C Angermeyer, Hans-Helmut König, Steffi G Riedel-Heller
OBJECTIVES: This study aims to investigate (1) motives, motivations and expectations regarding the choice for a specific rehabilitation setting after herniated disc surgery and (2) how rehabilitation-related motivations and expectations are associated with rehabilitation outcome (ability to work, health-related quality of life and satisfaction with rehabilitation) three months after disc surgery. METHODS: The longitudinal cohort study refers to 452 disc surgery patients participating in a subsequent rehabilitation...
2017: PloS One
Yanina Benedetti, Federico Morelli
Road and railway networks are pervasive elements of all environments, which have expanded intensively over the last century in all European countries. These transportation infrastructures have major impacts on the surrounding landscape, representing a threat to biodiversity. Roadsides and railways may function as corridors for dispersal of alien species in fragmented landscapes. However, only few studies have explored the spread of invasive species in relationship to transport network at large spatial scales...
2017: PloS One
Adeline D Fournet, Kylie J Mitchell, Wolfgang Wernsdorfer, Khalil A Abboud, George Christou
A new member of the Mn12 family of single-molecule magnets (SMMs) has been prepared and found to be the first of this family to give a 3-D ferromagnetic network. [Mn12O12(O2CC6H4-p-F)16(H2O)4] (2) was prepared by carboxylate substitution on the acetate derivative with p-F-benzoic acid and crystallizes as 2·8MeCN in space group I4̅2m with extensive formation of intermolecular C-H···F hydrogen-bonding. The latter leads to a combination of ferromagnetic (F) and antiferromagnetic (AF) interactions and an overall F network that gives a χMT value at low T that is abnormally high for an S = 10 ground state...
August 22, 2017: Inorganic Chemistry
Yadienka Martinez Rubi, Behnam Ashrafi, Michael B Jakubinek, Shan Zou, Kurtis Laqua, Michael Barnes, Benoit Simard
We have fabricated carbon nanotube (CNT)-polyurethane (TPU) sheets via a one-step filtration method that uses a TPU solvent/non-solvent combination. This solution method allows for control of the composition and processing conditions, significantly reducing both the filtration time and the need for large volumes of solvent to debundle the CNTs. Through an appropriate selection of the solvents and tuning the solvent/non-solvent ratio, it is possible to enhance the interaction between the CNTs and the polymer chains in solution and improve the CNT exfoliation in the nanocomposites...
August 22, 2017: ACS Applied Materials & Interfaces
Victoria Divino, Soledad Cepeda, Paul Coplan, Jean-Yves Maziere, Yingli Yuan, Rolin L Wade
OBJECTIVE: The Food and Drug Administration approved the extended-release/long-acting (ER/LA) opioid analgesics risk evaluation and mitigation strategies (REMS) in July 2012 to educate healthcare providers and patients about safe and appropriate opioid analgesic use. The authors evaluated the impact of the REMS on ER/LA opioid analgesic utilization, overall and stratified by patient characteristics and prescriber type associated with greater expected need for analgesia. DESIGN: Retrospective repeated cross-sectional study...
May 2017: Journal of Opioid Management
L Muzii, L Domenici, F Lecce, M Di Feliciantonio, R Frantellizzi, C Marchetti, M Monti, P Benedetti Panici
OBJECTIVE: Isthmocele represents a reservoir on the anterior wall of the uterine isthmus or of the cervical canal at the site of a previous cesarean delivery scar. Recently, it has been clarified that it might be the cause of several gynecologic symptoms, as most common abnormal uterine bleeding. Hysteroscopy and trans-vaginal ultrasound are considered the gold standard for the diagnosis of this defect. Resectoscopic treatment can be considered effective in small size defects, but no randomized clinical trials are available...
August 2017: European Review for Medical and Pharmacological Sciences
X-D Hou, F Ding, X-K Wang, X-G Liu, K Yi, P Zhang, T You
OBJECTIVE: The purpose of this work is to analyze the clinical results of treating severe mitral stenosis (MS) with mild to moderate functional tricuspid regurgitation (FTR) with mitral valve replacement (MVR) alone or together with two different methods of tricuspid valvuloplasty (TVP). PATIENTS AND METHODS: We split 132 patients into three groups: simple MVR with 47 cases (control group), MVR+ TVP (De Vega loop reduction) with 45 cases (observation group 1) and MVR+ TVP (Edwards MC3 tricuspid forming ring implantation) with 40 cases (observation group 2)...
August 2017: European Review for Medical and Pharmacological Sciences
Byungkyun Kang, Koushik Biswas
There has been considerable speculation over the nature of charge carriers in organic-inorganic hybrid perovskites, i.e., whether they are free and band-like, or they are prone to self-trapping via short range deformation potentials. Unusually long minority-carrier diffusion lengths and moderate-to-low mobilities, together with relatively few deep defects add to their intrigue. Here we implement density functional methods to investigate the room-temperature, tetragonal phase of CH3NH3PbI3. We compare charge localization behavior at shallow levels and associated lattice relaxation versus those at deep polaronic states...
August 22, 2017: Physical Chemistry Chemical Physics: PCCP
Stephen D Willis, A K M Nawshad Hossian, Nathan Evans, Mark J Hickman
Complex changes in gene expression typically mediate a large portion of a cellular response. Each gene may change expression with unique kinetics as the gene is regulated by the particular timing of one of many stimuli, signaling pathways or secondary effects. In order to capture the entire gene expression response to hypoxia in the yeast S. cerevisiae, RNA-seq analysis was used to monitor the mRNA levels of all genes at specific times after exposure to hypoxia. Hypoxia was established by growing cells in ~100% N2 gas...
August 10, 2017: Journal of Visualized Experiments: JoVE
Denis Benito, Michael Niederwanger, Urtzi Izagirre, Reinhard Dallinger, Manu Soto
Cadmium (Cd) is one of the most harmful metals, being toxic to most animal species, including marine invertebrates. Among marine gastropods, the periwinkle (Littorina littorea) in particular can accumulate high amounts of Cd in its midgut gland. In this organ, the metal can elicit extensive cytological and tissue-specific alterations that may reach, depending on the intensity of Cd exposure, from reversible lesions to pathological cellular disruptions. At the same time, Littorina littorea expresses a Cd-specific metallothionein (MT) that, due to its molecular features, expectedly exerts a protective function against the adverse intracellular effects of this metal...
August 22, 2017: International Journal of Molecular Sciences
Reija Ruuhela, Kirsti Jylhä, Timo Lanki, Pekka Tiittanen, Andreas Matzarakis
Climate change is expected to increase heat-related and decrease cold-related mortality. The extent of acclimatization of the population to gradually-changing thermal conditions is not well understood. We aimed to define the relationship between mortality and temperature extremes in different age groups in the Helsinki-Uusimaa hospital district in Southern Finland, and changes in sensitivity of the population to temperature extremes over the period of 1972-2014. Time series of mortality were made stationary with a method that utilizes 365-day Gaussian smoothing, removes trends and seasonality, and gives relative mortality as the result...
August 22, 2017: International Journal of Environmental Research and Public Health
Mikel Sagardia, Thomas Hulin
What are the technological bottlenecks in virtual assembly simulations with haptic feedback? To tackle this question, we present an evaluation study in which real feedback modalities are gradually replaced by synthetic ones. In particular, the effects of the following factors on the user performance and perception during virtual assemblies are analyzed: (i) a visual feedback system consisting of an nVisor head-mounted display, (ii) our haptic device HUG suited for unscaled upper-body movements, and (iii) our novel six-DoF constraint-based haptic rendering algorithm...
August 18, 2017: IEEE Transactions on Haptics
Kirsten Christensen-Jeffries, Sevan Harput, Jemma Brown, Peter N T Wells, Paul Aljabar, Chris Dunsby, Meng-Xing Tang, Robert J Eckersley
Acoustic super-resolution imaging has allowed visualization of microvascular structure and flow beyond the diffraction limit using standard clinical ultrasound systems through the localization of many spatially isolated microbubble signals. The determination of each microbubble position is typically performed by calculating the centroid, finding a local maximum, or finding the peak of a 2-D Gaussian function fit to the signal. However, the backscattered signal from a microbubble depends not only on diffraction characteristics of the waveform, but also on the microbubble behavior in the acoustic field...
August 17, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
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