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https://www.readbyqxmd.com/read/27900215/drug-treatment-of-bothersome-lower-urinary-tract-symptoms-after-ureteric-jj-stent-insertion-a-contemporary-comparative-prospective-randomised-placebo-controlled-study-single-centre-experience
#1
Ihab A Hekal
OBJECTIVE: To provide a guide for medication to alleviate bothersome lower urinary tract symptoms (LUTS) in patients after JJ ureteric stenting. PATIENTS AND METHODS: Between June 2011 and June 2015, a prospective randomised placebo-controlled study was conducted on 200 consecutive cases of ureteric stones that required JJ stents. All patients had signed informed consent and JJ-stent placement confirmed by X-ray. The patients were randomised into five groups: A, solifenacin 5 mg; B, trospium chloride 20 mg; C, antispasmodic; and E, α-blocker; and a placebo group (D)...
December 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27889999/comprehensive-assessment-of-compliance-with-antimuscarinic-drug-treatment-in-the-case-of-urge-urinary-incontinence-of-older-patients
#2
Kirill Vladimirovich Kosilov, Sergey Alexandrovich Loparev, Irina Gennadyevna Kuzina, Olga Viktorovna Shakirova, Natalya Sergeevna Zhuravskaya, Alexandra Lobodenko
AIM: study of heterogeneous factors affecting the stability of patients older than 60 years in the UI treatment with Antimuscarinics. BACKGROUND: The prevalence of urge incontinence (UI) in older persons reaches 29.3%. The symptoms of urinary incontinence in older people reduce the health related life quality. MATERIALS AND METHODS: In 1257 patients over 60 years (857 (68.2%) women - average age 67.8, 400 (31.8%) men - 71.4), who received AM for one year, demographic, socio-economic and health parameters were studied...
November 24, 2016: Current Aging Science
https://www.readbyqxmd.com/read/27878051/anticholinergics-for-overactive-bladder-temporal-trends-in-prescription-and-treatment-persistence
#3
Christopher J D Wallis, Colin Lundeen, Nicole Golda, Hilary Brotherhood, Peter Pommerville, Lesley Carr
INTRODUCTION: We sought to understand the contemporary pharmacologic management of overactive bladder (OAB) in a single-payer system. We examined temporal trends in the use of anticholinergic medications and assessed whether the likelihood of patients changing their anticholinergic therapy was predicted by their current therapy. METHODS: We conducted a retrospective, population-based analysis of prescription records from the PharmaNet database in BC, Canada. We identified patients treated with one or more anticholinergic prescriptions between 2001 and 2009...
August 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27738922/a-short-review-of-drug-food-interactions-of-medicines-treating-overactive-bladder-syndrome
#4
Paweł Paśko, Tomasz Rodacki, Renata Domagała-Rodacka, Danuta Owczarek
Background Overactive bladder syndrome is a condition where one or more of the symptoms such as pollakiuria, urgent need to urinate, nocturia and urinary incontinence is observed. Its prevalence ranges between 7 and 27 % in men and 9-43 % in women. The role of a pharmacist is to educate the patient on medications administration scheme, and drug interactions with particular food or food components. Aim of the review To assess a potential impact of food and fruit juice on the pharmacokinetic and therapeutic effects of medications used in treating overactive bladder syndrome...
December 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27579830/estimated-budget-impact-of-increased-use-of-mirabegron-a-novel-treatment-for-overactive-bladder
#5
Sinem Perk, Ronald C Wielage, Noll L Campbell, Timothy M Klein, Anthony Perkins, Linda M Posta, Thomas Yuran, Robert W Klein, Daniel B Ng
BACKGROUND: Oral pharmacological treatment for overactive bladder (OAB) consists of antimuscarinics and the beta-3 adrenergic agonist mirabegron. Antimuscarinic adverse events (AEs) such as dry mouth, constipation, and blurry vision can result in frequent treatment discontinuation rates, leaving part of the OAB population untreated. Antimuscarinics also contribute to a patient's anticholinergic cognitive burden (ACB), so the Beers Criteria recommends cautious use of antimuscarinics in elderly patients who take multiple anticholinergic medications or have cognitive impairment...
September 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27574750/estimated-budget-impact-of-increased-use-of-mirabegron-a-novel-treatment-for-overactive-bladder
#6
Sinem Perk, Ronald C Wielage, Noll L Campbell, Timothy M Klein, Anthony Perkins, Linda M Posta, Thomas Yuran, Robert W Klein, Daniel B Ng
BACKGROUND: Oral pharmacological treatment for overactive bladder (OAB) consists of antimuscarinics and the beta-3 adrenergic agonist mirabegron. Antimuscarinic adverse events (AEs) such as dry mouth, constipation, and blurry vision can result in frequent treatment discontinuation rates, leaving part of the OAB population untreated. Antimuscarinics also contribute to a patient's anticholinergic cognitive burden (ACB), so the Beers Criteria recommends cautious use of antimuscarinics in elderly patients who take multiple anticholinergic medications or have cognitive impairment...
September 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27374291/muscarinic-receptor-binding-in-rat-bladder-urothelium-and-detrusor-muscle-by-intravesical-solifenacin
#7
Yoshihiko Ito, Michishi Kashiwabara, Akira Yoshida, Eriko Hikiyama, Satomi Onoue, Shizuo Yamada
Solifenacin is an antimuscarinic agent used to treat symptoms of overactive bladder. Pharmacologically significant amounts of solifenacin were excreted in the urine of humans taking a clinical dose of this drug. The aim of this study is to measure muscarinic receptor binding in the bladder urothelium and detrusor muscles of rats following the intravesical instillation of solifenacin. Muscarinic receptors were measured by radioreceptor assay using [N-methyl-(3)H]scopolamine methyl chloride ([(3)H]NMS), a selective radioligand of muscarinic receptors...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27241452/an-integrative-review-of-standardized-clinical-evaluation-tool-utilization-in-anticholinergic-drug-trials-for-neurogenic-lower-urinary-tract-dysfunction
#8
L Stothers, B Tsang, M Nigro, D Lazare, A Macnab
STUDY DESIGN: To review prospective and randomized trials studying anticholinergic therapy for neurogenic bladder in SCI to identify whether trials included standardized clinical evaluation tools and reporting measures now recognized to enhance clinical trial data. METHODS: A systematic search via EMBASE, MEDLINE, CENTRAL, CINAHL (Cumulative Index to Nursing and Allied Health Literature), HTA (Health Technology Assessment), CMR (Comprehensive Microbial Resource), HAPI (Health and Psychosocial Instruments) and PsycINFO using the key term spinal cord injury crossed with oxybutynin, tolterodine, darifenacin, solifenacin, fesoterodine, trospium chloride, propiverine, propantheline and anticholinergic(s) for 1946-2015 inclusive...
May 31, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27037009/electrical-stimulation-with-non-implanted-electrodes-for-overactive-bladder-in-adults
#9
REVIEW
Fiona Stewart, Orsi L F Gameiro, Regina El Dib, Monica Orsi Gameiro, Anil Kapoor, Joao Luiz Amaro
BACKGROUND: Several options exist for managing overactive bladder (OAB), including electrical stimulation (ES) with non-implanted devices, conservative treatment and drugs. Electrical stimulation with non-implanted devices aims to inhibit contractions of the detrusor muscle, potentially reducing urinary frequency and urgency. OBJECTIVES: To determine the effectiveness of: ES with non-implanted electrodes compared with placebo or any other active treatment for OAB; ES added to another intervention compared with the other intervention alone; different methods of ES compared with each other...
April 2, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26886709/-pharmacotherapy-of-urinary-incontinence-in-the-elderly
#10
K F Becher
The prevalence and the incidence of Urinary Incontinence is growing. Women suffer predominantly from stress and mixed urinary incontinence and men from urge incontinence. In elderly people, the pathophysiological and the physiological change in the lower urinary tract system must be considered as well as an underlying multimorbidity. Stress urinary incontinence is among others caused by an insufficient urethral closure mechanism and urge incontinence is followed by unhibited detrusor contractions. Medical treatment is beside other important conservative options only one part of the treatment strategy in incontinence...
April 2016: Der Internist
https://www.readbyqxmd.com/read/26826771/-anticholinergics-do-not-affect-the-sexual-function-in-women-diagnosed-with-multiple-sclerosis
#11
J Di Marco, C De Broglie, P Manceau, L Weglinski, F Le Breton, D Verrollet, G Amarenco
AIM: Determine if the initiation of an anticholinergic treatment affects the sexual function in women diagnosed with multiple sclerosis (MS). METHODS: It was a single-centre prospective open label study on 18 women affected by MS, with a clinical overactive bladder syndrome, and examined before and after anticholinergic treatment. Several variables were studied before and after treatment: the total anticholinergic load (Anticholinergic Drug Scale [ADS]), the Female Sexual Function Index, the Urinary Symptom Profile (USP) and functional status (EDSS, MIF)...
March 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/26409605/cost-effectiveness-of-mirabegron-compared-with-antimuscarinic-agents-for-the-treatment-of-adults-with-overactive-bladder-in-the-united-kingdom
#12
COMPARATIVE STUDY
Jameel Nazir, Khaled Maman, Mohamed-Elmoctar Neine, Benjamin Briquet, Isaac A O Odeyemi, Zalmai Hakimi, Andy Garnham, Samuel Aballéa
BACKGROUND: Mirabegron, a first-in-class selective oral β3-adrenoceptor agonist, has similar efficacy to most antimuscarinic agents and a lower incidence of dry mouth in patients with overactive bladder (OAB). OBJECTIVES: To evaluate the cost-effectiveness of mirabegron 50 mg compared with oral antimuscarinic agents in adults with OAB from a UK National Health Service perspective. METHODS: A Markov model including health states for symptom severity, treatment status, and adverse events was developed...
September 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26186951/effectiveness-of-solifenacin-and-trospium-for-managing-of-severe-symptoms-of-overactive-bladder-in-patients-with-benign-prostatic-hyperplasia
#13
Kirill Vladimirovich Kosilov, Sergay A Loparev, Marina A Ivanovskaya, Liliya V Kosilova
This research is aimed to study the possibility of management of severe symptoms of overactive bladder (OAB) with solifenacin and trospium in patients who receive treatment with tamsulosin due to benign prostatic hyperplasia (BPH). The 338 men more than 50 years old (average age 58.4 years) diagnosed with BPH and severe symptoms of OAB were enrolled in the study. Over three episodes of urinary incontinence per day (registration according to bladder diaries), INTERNATIONAL PROSTATE SYMPTOM SCORE: over 19, OAB-V8 questionnaire score over 32, and urodynamic disorders diagnosed using cystometry and uroflowmetry were taken as a criterion of severe symptoms of OAB...
March 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/26169438/managing-urinary-incontinence-in-patients-with-dementia-pharmacological-treatment-options-and-considerations
#14
REVIEW
Susie Orme, Vikky Morris, William Gibson, Adrian Wagg
Urinary incontinence and lower urinary tract symptoms are highly prevalent in late life and are strongly associated with dementia and frailty. Incontinence is extremely common among those living in long-term care and is most commonly due to urgency incontinence. Although national and international guidelines for continence care exist, they often fail to consider the complex comorbidity found in patients with dementia and are often not followed; continence practices in long-term care may promote rather than prevent incontinence...
July 2015: Drugs & Aging
https://www.readbyqxmd.com/read/26104505/appropriateness-of-oral-drugs-for-long-term-treatment-of-lower-urinary-tract-symptoms-in-older-persons-results-of-a-systematic-literature-review-and-international-consensus-validation-process-luts-forta-2014
#15
REVIEW
Matthias Oelke, Klaus Becher, David Castro-Diaz, Emmanuel Chartier-Kastler, Mike Kirby, Adrian Wagg, Martin Wehling
AIM: we aimed to systematically review drugs to treat lower urinary tract symptoms (LUTS) regularly used in older persons to classify appropriate and inappropriate drugs based on efficacy, safety and tolerability by using the Fit fOR The Aged (FORTA) classification. METHODS: to evaluate the efficacy, safety and tolerability of drugs used for treatment of LUTS in older persons, a systematic review was performed. Papers on clinical trials and summaries of individual product characteristics were analysed regarding efficacy and safety in older persons (≥65 years)...
September 2015: Age and Ageing
https://www.readbyqxmd.com/read/26084660/the-role-of-muscarinic-receptor-subtypes-on-carbachol-induced-contraction-of-normal-human-detrusor-and-overactive-detrusor-associated-with-benign-prostatic-hyperplasia
#16
Tomonori Yamanishi, Kanya Kaga, Miki Fuse, Chiharu Shibata, Takao Kamai, Tomoyuki Uchiyama
The aim of this study was to compare the effect of antimuscarinic antagonists on carbachol-induced contraction of normal human bladder and detrusor overactivity associated with benign prostatic hyperplasia (DO/BPH). Samples of human bladder muscle were obtained from patients undergoing total cystectomy for bladder cancer (normal bladder), and those undergoing retropubic prostatectomy for BPH. All of the patients with DO/BPH had detrusor overactivity according to urodynamic studies. Detrusor muscle strips were mounted in 10-ml organ baths containing Krebs solution, and concentration-response curves for carbachol were obtained in the presence of antimuscarinic antagonists (4-DAMP, methoctramine, pirenzepine, tolterodine, solifenacin, trospium, propiverine, oxybutynin, and imidafenacin) or vehicle...
June 2015: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/25656412/effect-of-pharmacological-treatment-for-urinary-incontinence-in-the-elderly-and-frail-elderly-a-systematic-review
#17
REVIEW
Eva Samuelsson, Jenny Odeberg, Karin Stenzelius, Ulla Molander, Margareta Hammarström, Karin Franzen, Gunnel Andersson, Patrik Midlöv
AIM: The prevalence and severity of urinary incontinence (UI) increase with age and comorbidity. The benefits of pharmacotherapy for UI in the elderly are questionable. The aim of the present study was to systematically review the efficacy of pharmacological treatment for UI in the elderly and frail elderly. METHODS: We searched PubMed, EMBASE, Cochrane library and Cinahl databases through October 2013 to identify prospective controlled trials that evaluated pharmacological treatment for UI in persons aged ≥65 years...
May 2015: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/25435915/randomized-controlled-trial-of-cyclic-and-continuous-therapy-with-trospium-and-solifenacin-combination-for-severe-overactive-bladder-in-elderly-patients-with-regard-to-patient-compliance
#18
Kirill V Kosilov, Sergay A Loparev, Marina A Ivanovskaya, Liliya V Kosilova
OBJECTIVES: The aim of the study was to increase the efficiency of treatment for severe symptoms of overactive bladder (OAB) with antimuscarinic drugs in elderly men and women. METHODS: A total of 341 patients over 65 years of age (average age 69.9; 186 women and 155 men) with severe symptoms of OAB (frequency of incontinence episodes [IEs] ≥ 3/day) underwent examination. Patients were distributed into three main groups: A (n = 58; trospium 60 mg/day + solifenacin 20): three cycles, each cycle 8 weeks, with an 8-week interval; B (n = 55; trospium 30 mg/day + solifenacin 10), regimen was the same as in group A; C (n = 62; trospium 30 mg/day + solifenacin 10) daily during 1 year...
December 2014: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/25214448/-impact-on-cognitive-function-of-anticholinergic-drugs-used-for-the-treatment-of-overactive-bladder-in-the-elderly
#19
REVIEW
J Kerdraon, G Robain, C Jeandel, P Mongiat Artus, X Gamé, B Fatton, M C Scheiber-Nogueira, J-M Vetel, P Mares, A-C Petit, G Amarenco
OBJECTIVES: Describe the central nervous system (CNS) adverse effects of anticholinergic drugs used for the treatment of overactive bladder (OAB) in the elderly. PATIENTS AND METHODS: Relevant data from the literature were identified primarily through a Medline search of articles published through December 2013. The search terms included overactive bladder, central nervous system, elderly, anticholinergic, and antimuscarinic. Articles were chosen for inclusion based on their pertinence to the focus on treatment of OAB in the elderly...
September 2014: Progrès en Urologie
https://www.readbyqxmd.com/read/25198276/discontinuation-of-treatment-using-anticholinergic-medications-in-patients-with-urinary-incontinence
#20
Matthias Kalder, Konstantinos Pantazis, Konstantinos Dinas, Ute-Susann Albert, Christina Heilmaier, Karel Kostev
OBJECTIVE: To evaluate the discontinuation rates of anticholinergics prescribed in patients with urinary incontinence (UI). METHODS: Data from a Disease Analyzer database including 988 general, 95 urologist, and 203 gynecologic practices were examined. Twenty six thousand eight hundred thirty-four patients were identified as having received a first-time anticholinergic prescription for UI, namely darifenacin, fesoterodine, oxybutynin, propiverine, solifenacin, tolterodine, or trospium, between 2005 and 2012...
October 2014: Obstetrics and Gynecology
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