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https://www.readbyqxmd.com/read/29895985/correction-genetic-variants-in-pnpla3-and-tm6sf2-predispose-to-the-development-of-hepatocellular-carcinoma-in-individuals-with-alcohol-related-cirrhosis
#1
Felix Stickel, Stephan Buch, Hans Dieter Nischalke, Karl Heinz Weiss, Daniel Gotthardt, Janett Fischer, Jonas Rosendahl, Astrid Marot, Mona Elamly, Markus Casper, Frank Lammert, Andrew McQuillin, Steffen Zopf, Ulrich Spengler, Silke Marhenke, Martha M Kirstein, Arndt Vogel, Florian Eyer, Johann von Felden, Henning Wege, Thorsten Buch, Clemens Schafmayer, Felix Braun, Pierre Deltenre, Thomas Berg, Marsha Y Morgan, Jochen Hampe
Author Pierre Deltenre, MD should appear in the author list in position 25, between Felix Braun and Thomas Berg. He should also have a PhD degree added to his name.
June 11, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29883377/circulating-phospholipid-patterns-in-nafld-patients-associated-with-a-combination-of-metabolic-risk-factors
#2
Shilpa Tiwari-Heckler, Hongying Gan-Schreier, Wolfgang Stremmel, Walee Chamulitrat, Anita Pathil
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is associated with inefficient macro- and micronutrient metabolism, and alteration of circulating phospholipid compositions defines the signature of NAFLD. This current study aimed to assess the pattern of serum phospholipids in the spectrum of NAFLD, and its related comorbidities and genetic modifications. METHODS: 97 patients with diagnosed NAFLD were recruited at a single center during 2013⁻2016. Based on histological and transient elastography assessment, 69 patients were divided into non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver (NAFL) subgroups...
May 21, 2018: Nutrients
https://www.readbyqxmd.com/read/29864915/dihydrocurcumin-ameliorates-the-lipid-accumulation-oxidative-stress-and-insulin-resistance-in-oleic-acid-induced-l02-and-hepg2-cells
#3
Qingqing Yu, Yayun Liu, Yufei Wu, Yong Chen
AIMS: Curcumin is a polyphenol compound with many pharmacological activities including antioxidant, lipid-loweing and liver protective. Dihydrocurcumin (DHC) is one of the major metabolites of curcumin. So far, the pharmacological activity of DHC has not been reported. Here, we evaluate the effects of DHC on oleic acid (OA)-induced lipid accumulation, oxidative stress and insulin resistance and the underlying mechanism in L02 and HepG2 cells. MAIN METHODS: OA-induced L02 and HepG2 cells were used as the in vitro model of nonalcoholic fatty liver disease (NAFLD)...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29761171/coding-variants-in-pnpla3-and-tm6sf2-are-risk-factors-for-hepatic-steatosis-and-elevated-serum-alanine-aminotransferases-caused-by-a-glucagon-receptor-antagonist
#4
Cristina B Guzman, Suman Duvvuru, Anthony Akkari, Pallav Bhatnagar, Chakib Battioui, Wendra Foster, Xiaotian Michelle Zhang, Sudha S Shankar, Mark A Deeg, Naga Chalasani, Thomas A Hardy, Christof M Kazda, Sreekumar G Pillai
LY2409021 is a glucagon receptor antagonist that was associated with hepatic steatosis and elevated aminotransferases in phase 2 diabetes studies. We investigated the relationship between selected genetic variants and hepatic steatosis and elevated alanine aminotransferases (ALTs) associated with LY2409021. Patients participated in a 6-week placebo-controlled trial (I1R-MC-GLDI [GLDI], n = 246) and a 52-week placebo- and active comparator-controlled trial (I1R-MC-GLDJ [GLDJ], n = 158). GLDJ had endpoints at 6 months, including measures of hepatic fat fraction (HFF) by magnetic resonance imaging...
May 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29732362/combining-genetic-variants-to-improve-risk-prediction-for-nafld-and-its-progression-to-cirrhosis-a-proof-of-concept-study
#5
Umberto Vespasiani-Gentilucci, Chiara Dell'Unto, Antonio De Vincentis, Andrea Baiocchini, Marco Delle Monache, Roberto Cecere, Adriano Maria Pellicelli, Valerio Giannelli, Simone Carotti, Giovanni Galati, Paolo Gallo, Francesco Valentini, Franca Del Nonno, Davide Rosati, Sergio Morini, Raffaele Antonelli-Incalzi, Antonio Picardi
Background & Aims: Identifying NAFLD patients at risk of progression is crucial to orient medical care and resources. We aimed to verify if the effects determined by different single nucleotide polymorphisms (SNPs) could add up to multiply the risk of NAFLD and NASH-cirrhosis. Methods: Three study populations, that is, patients diagnosed with NASH-cirrhosis or with noncirrhotic NAFLD and healthy controls, were enrolled. PNPLA3 rs738409, TM6SF2 rs58542926, KLF6 rs3750861, SOD2 rs4880, and LPIN1 rs13412852 were genotyped...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29708925/unexplained-reciprocal-regulation-of-diabetes-and-lipoproteins
#6
Sei Higuchi, M Concepción Izquierdo, Rebecca A Haeusler
PURPOSE OF REVIEW: Type 2 diabetes is associated with a characteristic dyslipidemia that may exacerbate cardiovascular risk. The causes of, and the effects of new antihyperglycemia medications on, this dyslipidemia, are under investigation. In an unexpected reciprocal manner, lowering LDL-cholesterol with statins slightly increases the risk of diabetes. Here we review the latest findings. RECENT FINDINGS: The inverse relationship between LDL-cholesterol and diabetes has now been confirmed by multiple lines of evidence...
June 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29700094/genetics-of-alcoholic-liver-disease-and-non-alcoholic-steatohepatitis
#7
Emma Scott, Quentin M Anstee
Alcohol-related liver disease (ARLD) and non-alcoholic fatty liver disease (NAFLD) are leading causes of chronic liver disease globally. Both ARLD and NAFLD are multifactorial and refer to a spectrum of disease severity, ranging from steatosis through steatohepatitis to fibrosis and cirrhosis. Both diseases exhibit substantial inter-patient variation in long-term outcomes and are best considered complex disease traits where genetic and environmental factors interact to mediate disease severity and progression...
April 1, 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29674183/pnpla3-rs738409-polymorphism-is-associated-with-liver-fibrosis-progression-in-patients-with-chronic-hepatitis-c-a-repeated-measures-study
#8
María Ángeles Jiménez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Juan José Sánchez-Ruano, Amanda Fernández-Rodríguez, Tomas Artaza-Varasa, Alicia Gómez-Sanz, María Martín-Vicente, Sonia Vázquez-Morón, Salvador Resino
BACKGROUND: Host genetic background has been associated with liver fibrosis progression. OBJECTIVE: To analyze the association between the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and liver fibrosis progression in hepatitis C virus (HCV)-infected patients. STUDY DESIGN: In this retrospective cohort study, 187 patients with chronic HCV infection were included, who had at least two liver stiffness measurements (LSM) by transient elastography during the follow-up...
June 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29671945/the-rs4686434-variant-in-the-fetuin-b-fetub-locus-is-associated-with-intrahepatic-triglyceride-content-in-obese-chinese-adults
#9
Zhibin Li, Mingzhu Lin, Changqin Liu, Zheng Chen, Dongmei Wang, Xiulin Shi, Shuyu Yang, Xue-Jun Li
BACKGROUND: This study explored associations of genetic variants in the fetuin B (FETUB) locus with intrahepatic triglyceride (IHTG) content. METHODS: Four tagging single-nucleotide polymorphisms (SNPs) of the FETUB locus and patatin-like phospholipase domain containing 3 (PNPLA3) rs738409 and transmembrane 6 super family member 2 (TM6SF2) rs58542926 were genotyped in 418 obese Chinese adults in whom serum FETUB and IHTG were measured. RESULTS: Subjects carrying the minor G allele for FETUB rs4686434 (AG/GG) had lower serum FETUB levels (mean [±SD] 3...
April 19, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29665034/metabolic-features-of-nonalcoholic-fatty-liver-nafl-in-obese-adolescents-findings-from-a-multi-ethnic-cohort
#10
Domenico Tricò, Sonia Caprio, Giuseppina Rosaria Umano, Bridget Pierpont, Jessica Nouws, Alfonso Galderisi, Grace Kim, Mariana M Mata, Nicola Santoro
AIMS: We conducted a prospective study in a large, multiethnic cohort of obese adolescents to characterize clinical and genetic features associated with pediatric Non-Alcoholic Fatty Liver (NAFL), the most common cause of chronic liver disease in youth. METHODS: A total of 503 obese adolescents were enrolled, including 191 (38.0%) Caucasians, 134 (26.6%) African Americans, and 178 (35.4%) Hispanics. Participants underwent abdominal magnetic resonance imaging (MRI) to quantify hepatic fat content, an oral glucose tolerance test to assess glucose tolerance and insulin sensitivity, and the genotyping of three SNPs associated with fatty liver (PNPLA3 rs738409, GCKR rs1260326, and TM6SF2 rs58542926)...
April 17, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29648650/nafld-risk-alleles-in-pnpla3-tm6sf2-gckr-and-lyplal1-show-divergent-metabolic-effects
#11
Eeva Sliz, Sylvain Sebert, Peter Würtz, Antti J Kangas, Pasi Soininen, Terho Lehtimäki, Mika Kähönen, Jorma Viikari, Minna Männikkö, Mika Ala-Korpela, Olli T Raitakari, Johannes Kettunen
Fatty liver has been associated with unfavourable metabolic changes in circulation. To provide insights in fatty liver-related metabolic deviations, we compared metabolic association profile of fatty liver versus metabolic association profiles of genotypes increasing the risk of non-alcoholic fatty liver disease (NAFLD). The cross-sectional associations of ultrasound-ascertained fatty liver with 123 metabolic measures were determined in 1810 (Nfatty liver = 338) individuals aged 34-49 years from The Cardiovascular Risk in Young Finns Study...
June 15, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29616948/dietary-patterns-in-nafld-and-their-interaction-with-polymorphisms-in-pnpla3-and-tm6sf2-genes
#12
Dimitra Borsa, Ioanna-Panagiota Kalafati, John Vlachogiannakos, Konstantinos Revenas, Alexander Kokkinos, Spyridon Ladas, George Dedoussis
No abstract text is available yet for this article.
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29609501/the-relationship-between-obesity-and-the-severity-of-non-alcoholic-fatty-liver-disease-systematic-review-and-meta-analysis
#13
Feng-Bin Lu, En-De Hu, Lan-Man Xu, Lu Chen, Jin-Lu Wu, Hui Li, Da-Zhi Chen, Yong-Ping Chen
A number of researches have explored the association between obesity and nonalcoholic fatty liver disease (NAFLD) liver function, histopathology, complications, genetic factors and prognosis, but the results were conflicting and inconclusive. Areas covered: In this meta-analysis, the liver function, histopathology, metabolic complications, patatin-like phospholipase domain-containing protein 3 (PNPLA3) genetic polymorphism and prognosis were compared between non-obese and obese NAFLD. Pubmed, EMBASE, Cochrane databases were searched to identify eligible studies...
May 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29601441/the-membrane-bound-o-acyltransferase7-rs641738-variant-in-pediatric-nonalcoholic-fatty-liver-disease
#14
Anna Di Sessa, Giuseppina Rosaria Umano, Grazia Cirillo, Angela Del Prete, Roberta Iacomino, Pierluigi Marzuillo, Emanuele Miraglia Del Giudice
BACKGROUND: The rs641738 polymorphism in the membrane-bound O-acyltransferase domain containing protein 7 (MBOAT7) gene has been associated with increased risk of nonalcoholic fatty liver disease (NAFLD). OBJECTIVES: To investigate the association between the MBOAT7 rs641738 polymorphism and both hepatic steatosis and biochemical markers of liver damage and to evaluate the potential additive effect of this variant and the I148M patatin-like phospholipase domain-containing 3 (PNPLA3) and the rs58542926 transmembrane 6 superfamily member 2 (TM6SF2) polymorphisms...
March 29, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29595690/a-novel-index-including-snps-for-the-screening-of-nonalcoholic-fatty-liver-disease-among-elder-chinese-a-population-based-study
#15
Huanhuan Yang, Guochong Chen, Chunli Song, Deming Li, Qinghua Ma, Guangliang Chen, Xinli Li
Presently noninvasive methods were employed to the diagnosis of nonalcoholic fatty liver disease (NAFLD), including fatty liver index (FLI), hepatic steatosis index (HSI), product of fasting triglyceride and glucose levels (TyG), and single nucleotide polymorphism (SNP), whereas the accuracy of those indexes need to be improved. Our study aimed to investigate the feasibility of a new index comprehensive index (CI), consisting of 6 serum biomarkers and anthropometric parameters through multivariate logistic regression analysis, to the earlier detection of NAFLD, and the diagnostic value of 5 SNPs (S1: rs2854116 of apolipoprotein C3 [APOC3], S2: rs4149267 of ATP-binding cassette transporter [ABCA1], S3: rs13702 of lipoprotein lipase [LPL], S4: rs738409 of protein 3 [patatin-like phospholipase domain containing protein 3 (PNPLA3)], S5: rs780094 of glucokinase regulatory protein gene [GCKR]) for NAFLD were also explored...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29593668/simulation-study-of-cdna-dataset-to-investigate-possible-association-of-differentially-expressed-genes-of-human-thp1-monocytic-cells-in-cancer-progression-affected-by-bacterial-shiga-toxins
#16
Syed A Muhammad, Jinlei Guo, Thanh M Nguyen, Xiaogang Wu, Baogang Bai, X Frank Yang, Jake Y Chen
Shiga toxin (Stxs) is a family of structurally and functionally related bacterial cytotoxins produced by Shigella dysenteriae serotype 1 and shigatoxigenic group of Escherichia coli that cause shigellosis and hemorrhagic colitis, respectively. Until recently, it has been thought that Stxs only inhibits the protein synthesis and induces expression to a limited number of genes in host cells, but recent data showed that Stxs can trigger several signaling pathways in mammalian cells and activate cell cycle and apoptosis...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29578593/high-frequency-of-the-pnpla3-rs738409-g-single-nucleotide-polymorphism-in-hmong-individuals-as-a-potential-basis-for-a-predisposition-to-chronic-liver-disease
#17
Clifford G Tepper, Julie H T Dang, Susan L Stewart, Dao M Fang, Kimberly A Wong, Stephenie Y Liu, Ryan R Davis, Doan Y Dao, Jeffrey P Gregg, Natalie J Török, Moon S Chen
BACKGROUND: An exploratory study was performed to determine the prevalence of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs78409 [G] allele among the Hmong as a risk factor for nonalcoholic fatty liver disease (NAFLD). NAFLD/nonalcoholic steatohepatitis is the world's most common chronic liver disease and is expected to replace viral hepatitis as the leading cause of cirrhosis and potential precursor to hepatocellular carcinoma (HCC). Of all populations in California, the Hmong experience the highest risk of death from HCC and the highest prevalence of metabolic syndrome risk factors among Asians that predispose them to NAFLD...
April 1, 2018: Cancer
https://www.readbyqxmd.com/read/29577560/prevalence-and-severity-of-nonalcoholic-fatty-liver-disease-by-transient-elastography-genetic-and-metabolic-risk-factors-in-a-general-population
#18
Salvatore Petta, Vito Di Marco, Rosaria Maria Pipitone, Stefania Grimaudo, Carola Buscemi, Antonio Craxì, Silvio Buscemi
BACKGROUND & AIMS: The worldwide spread of obesity is leading to a dramatic increase in the prevalence of nonalcoholic fatty liver disease (NAFLD) and its complications. We aimed to evaluate both prevalence and factors associated with NAFLD in a general population in a Mediterranean area. METHODS: We considered 890 consecutive individuals included in the community-based ABCD (Alimentazione, Benessere Cardiovascolare e Diabete) study (ISRCTN15840340). Controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) were measured with FibroScan...
March 25, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29574608/fish-intake-interacts-with-tm6sf2-gene-variant-to-affect-nafld-risk-results-of-a-case-control-study
#19
I P Kalafati, M Dimitriou, D Borsa, J Vlachogiannakos, K Revenas, A Kokkinos, S D Ladas, G V Dedoussis
PURPOSE: Non-alcoholic fatty liver disease (NAFLD) is a complex disease, resulting from a variety of genetic and environmental factors. The aim of this case-control study was to evaluate the effect of selected genetic polymorphisms, nutrition aspects and their interaction on the risk of NAFLD. METHODS: The sample consisted of 134 patients with NAFLD and 217 controls. Disease was diagnosed by liver ultrasound and volunteers were clinically and nutritionally assessed...
March 24, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29562725/genetic-and-epigenetic-regulation-in-nonalcoholic-fatty-liver-disease-nafld
#20
REVIEW
José A Del Campo, Rocío Gallego-Durán, Paloma Gallego, Lourdes Grande
Genetics and epigenetics play a key role in the development of several diseases, including nonalcoholic fatty liver disease (NAFLD). Family studies demonstrate that first degree relatives of patients with NAFLD are at a much higher risk of the disease than the general population. The development of the Genome Wide Association Study (GWAS) technology has allowed the identification of numerous genetic polymorphisms involved in the evolution of diseases (e.g., PNPLA3 , MBOAT7 ). On the other hand, epigenetic changes interact with inherited risk factors to determine an individual's susceptibility to NAFLD...
March 19, 2018: International Journal of Molecular Sciences
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