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https://www.readbyqxmd.com/read/29932859/short-duration-rapid-chilling-of-mastectomy-specimens-does-not-interfere-with-breast-cancer-biomarker-and-molecular-testing
#1
Asangi R Kumarapeli, William Bellamy, Ericka Olgaard, Nicole Massoll, Soheila Korourian
CONTEXT: - A thorough gross examination of specimens for breast cancer requires the tissue to be very thinly sectioned, which is often difficult in large mastectomy samples. We have implemented rapid chilling of mastectomy specimens before formalin fixation. OBJECTIVE: - To evaluate the effects of rapid chilling of breast tissue on subsequent biomarker and molecular testing. DESIGN: - Mastectomy specimens were chilled at -80°C for 20 minutes to facilitate uniform sectioning of tissue at 4-mm intervals and enhance proper fixation and identification of small lesions...
June 22, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29931061/successful-targeted-therapies-for-breast-cancer-the-worcester-foundation-and-future-opportunities-in-women-s-health
#2
Balkees Abderrahman, V Craig Jordan
The signing of the National Cancer Act in 1971, was designed to take laboratory discoveries rapidly from the bench to the bedside. A "war on cancer" had been declared. Combination cytotoxic chemotherapy was predicted to cure all cancers based on the stunning success in treating childhood leukemia. Breast cancer treatments were primitive; radical mastectomy and radiation was standard of care for disease that had not spread. Ablative endocrine surgery (oophorectomy, hypophysectomy, and adrenalectomy) was a palliative last option for metastatic breast cancer...
June 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29930189/paraneoplastic-cerebellar-degeneration-with-bilateral-facial-palsy-a-rare-primary-presentation-of-breast-cancer
#3
Arihant Jain, Manu Vats, Sushanto Neogi, Geeta Anjum Khwaja
Paraneoplastic cerebellar degeneration is a rare dysfunction of the cerebellum associated with malignancy. Nevertheless, it is the most common paraneoplastic syndrome affecting the brain. A 50-year-old woman presented to the neurology outpatient department (OPD) with symptoms of cerebellar dysfunction since 4 months and complaints of a painless lump in the right breast and drooling from mouth since 1 month. Examination revealed classical signs of cerebellar dysfunction and a 5×5 cm lump in the right breast with a single right axillary lymph node...
June 21, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29929997/hereditary-lobular-breast-cancer-with-an-emphasis-on-e-cadherin-genetic-defect
#4
Giovanni Corso, Joana Figueiredo, Carlo La Vecchia, Paolo Veronesi, Gabriella Pravettoni, Debora Macis, Rachid Karam, Roberto Lo Gullo, Elena Provenzano, Antonio Toesca, Ketti Mazzocco, Fátima Carneiro, Raquel Seruca, Soraia Melo, Fernando Schmitt, Franco Roviello, Alessandra Margherita De Scalzi, Mattia Intra, Irene Feroce, Elisa De Camilli, Maria Grazia Villardita, Chiara Trentin, Francesca De Lorenzi, Bernardo Bonanni, Viviana Galimberti
Recent studies have reported germline CDH1 mutations in cases of lobular breast cancer (LBC) not associated with the classical hereditary diffuse gastric cancer syndrome. A multidisciplinary workgroup discussed genetic susceptibility, pathophysiology and clinical management of hereditary LBC (HLBC). The team has established the clinical criteria for CDH1 screening and results' interpretation, and created consensus guidelines regarding genetic counselling, breast surveillance and imaging techniques, clinicopathological findings, psychological and decisional support, as well as prophylactic surgery and plastic reconstruction...
June 21, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29927832/comparison-of-immediate-versus-delayed-deep-inferior-epigastric-artery-perforator-diep-flap-reconstruction-in-women-who-require-post-mastectomy-radiotherapy
#5
Rachel L O'Connell, Rosa Di Micco, Komel Khabra, Anna M Kirby, Paul A Harris, Stuart E James, Kieran Power, Kelvin Wd Ramsey, Jennifer E Rusby
INTRODUCTION: The aim of this study was to investigate aesthetic outcome and patient satisfaction in women who have undergone DIEP reconstruction in the setting of PMRT. Patients who underwent DIEP reconstruction without PMRT were the control group. METHODS: Participants who had undergone DIEP between 9/1/2009-9/1/2014 were recruited, answered the BREAST-Q and underwent 3D surface-imaging. A panel assessed the aesthetic outcome by reviewing these images. RESULTS: 167 women participated...
June 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29926900/breast-conserving-surgery-followed-by-whole-breast-irradiation-offers-survival-benefits-over-mastectomy-without-irradiation
#6
J de Boniface, J Frisell, L Bergkvist, Y Andersson
BACKGROUND: The prognostic equivalence between mastectomy and breast-conserving surgery (BCS) followed by radiotherapy was shown in pivotal trials conducted decades ago. Since then, detection and treatment of breast cancer have improved substantially and recent retrospective analyses point towards a survival benefit for less extensive breast surgery. Evidence for the association of such survival data with locoregional recurrence rates is largely lacking. METHODS: The Swedish Multicentre Cohort Study prospectively included clinically node-negative patients with breast cancer who had planned sentinel node biopsy between 2000 and 2004...
June 21, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29926096/long-term-patient-reported-outcomes-in-postmastectomy-breast-reconstruction
#7
Katherine B Santosa, Ji Qi, Hyungjin M Kim, Jennifer B Hamill, Edwin G Wilkins, Andrea L Pusic
Importance: Previous outcome studies comparing implant and autologous breast reconstruction techniques have been limited by short-term follow-up, single-center design, and a lack of rigorous patient-reported outcome data. An understanding of the expected satisfaction and breast-related quality of life associated with each type of procedure is central to the decision-making process. Objective: To determine outcomes reported by patients undergoing postmastectomy breast reconstruction using implant or autologous techniques 2 years after surgery...
June 20, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29926077/comparison-of-2-year-complication-rates-among-common-techniques-for-postmastectomy-breast-reconstruction
#8
Katelyn G Bennett, Ji Qi, Hyungjin M Kim, Jennifer B Hamill, Andrea L Pusic, Edwin G Wilkins
Importance: In breast reconstruction, it is critical for patients and surgeons to have comprehensive information on the relative risks of the available options. However, previous studies that evaluated complications were limited by single-center designs, inadequate follow-up, and confounding. Objective: To assess 2-year complication rates across common techniques for postmastectomy reconstruction in a multicenter patient population. Design, Setting, and Participants: This longitudinal, multicenter, prospective cohort study conducted from February 1, 2012, through July 31, 2015, took place at the 11 study sites associated with the Mastectomy Reconstruction Outcomes Consortium study...
June 20, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29923341/organochlorine-pesticide-residues-in-human-breast-tissue-and-their-relationships-with-clinical-and-pathological-characteristics-of-breast-cancer
#9
Rachel E Ellsworth, Paul J Kostyniak, Lai-Har Chi, Craig D Shriver, Nicholas S Costantino, Darrell L Ellsworth
Agricultural pesticides are abundant environmental contaminants worldwide, prompting interest in studying their possible detrimental health effects. We examined organochlorine residues by quadrant (n = 245) in breast adipose tissues from 51 women with various stages of breast health to determine patterns of bioaccumulation within the breast and to assess relationships with patient clinical characteristics. Three organochlorine residues-2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), hexachlorobenzene (HCB), and mirex-assayed by high resolution gas chromatography were abundant in breast tissue...
June 19, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29922561/a-new-approach-to-nipple-sparing-mastectomy-and-reconstruction-in-the-high-risk-ptotic-patient
#10
Jean-Claude Schwartz
Nipple-sparing mastectomy (NSM) and reconstruction is challenging in ptotic patients with additional risk factors. Here, these problems are addressed with a staged strategy that extends NSM and reconstruction to patients with grade 3 ptosis and additional risk factors of diabetes, obesity, and macromastia. Three stages are used to perform a mastectomy, reposition the nipple, and reduce the skin envelope using the Wise pattern. This is followed by definitive implant placement in a final fourth stage. All patients successfully completed their reconstructions without a single instance of implant loss...
May 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29922103/utilizing-the-total-design-method-in-medicine-maximizing-response-rates-in-long-non-incentivized-personal-questionnaire-postal-surveys
#11
Fawz Kazzazi, Rebecca Haggie, Parto Forouhi, Nazar Kazzazi, Charles M Malata
Introduction: Maximizing response rates in questionnaires can improve their validity and quality by reducing non-response bias. A comprehensive analysis is essential for producing reasonable conclusions in patient-reported outcome research particularly for topics of a sensitive nature. This often makes long (≥7 pages) questionnaires necessary but these have been shown to reduce response rates in mail surveys. Our work adapted the "Total Design Method," initially produced for commercial markets, to raise response rates in a long (total: 11 pages, 116 questions), non-incentivized, very personal postal survey sent to almost 350 women...
2018: Patient related Outcome Measures
https://www.readbyqxmd.com/read/29916894/modified-treatment-algorithm-for-pseudogynecomastia-after-massive-weight-loss
#12
Ulrich E Ziegler, Udo Lorenz, Adrien Daigeler, Selina N Ziegler, Philip H Zeplin
BACKGROUND: Pseudogynecomastia is the increased aggregation of fatty tissue in the area of the male breast with resultant female appearance. Two forms can appear: pseudogynecomastia after massive weight loss (pseudogynecomastia obese [PO]) and pseudogynecomastia, which is caused only by adipose tissue (pseudogynecomastia fat). For PO, only the Gusenoff classification with corresponding operative treatment options exists. However, this classification is limited by the fact that it underestimates the extensive variability of residual fat tissue and skin excess, both crucial factors for operative planning...
June 19, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29916008/heterogeneity-in-outcomes-of-pathologic-t1-2n1-breast-cancer-after-mastectomy-looking-beyond-locoregional-failure-rates
#13
Jose G Bazan, Lonika Majithia, Allison M Quick, Jessica L Wobb, Alicia M Terando, Doreen M Agnese, William Farrar, Julia R White
PURPOSE: A meta-analysis of 22 randomized trials accrued from 1964 to 1986 demonstrated significantly higher rates of locoregional failure (LRF) and breast-cancer mortality in women with 1-3 positive nodes without postmastectomy radiotherapy (PMRT) after mastectomy (mast.). Recent data demonstrate that PMRT reduces distant metastases (DM) in women with pN1 disease. The challenge today is whether all patients with pathologic T1-2pN1 disease have similar substantial LRF/DM risk that routinely warrants PMRT...
June 18, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29914691/adjuvant-radiation-therapy-for-t3n0-breast-cancer-patients-older-than-75-years-after-mastectomy-a-seer-analysis
#14
Jonathan Chen, Xian Wu, Paul Christos, Weisi Yan, Akkamma Ravi
INTRODUCTION: Breast cancer patients with tumors > 5 cm but without nodal disease who undergo mastectomy present a clinical challenge regarding the appropriate adjuvant treatment. Traditionally, postmastectomy radiation therapy (PMRT) was the standard of care. However, recent studies have suggested local failure rates without PMRT might be low enough to omit RT. This might be especially true in the elderly. PATIENTS AND METHODS: Women aged ≥ 75 years with a diagnosis of T3N0 breast cancer who had undergone mastectomy were identified from the Surveillance, Epidemiology, and End Results (SEER) 18 database...
June 15, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29914426/effects-of-local-anesthetics-on-breast-cancer-cell-viability-and-migration
#15
Ru Li, Chunyun Xiao, Hengrui Liu, Yujie Huang, James P Dilger, Jun Lin
BACKGROUND: Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery. Retrospective clinical studies have suggested that use of regional anesthesia leads to improved patient outcomes. Laboratory studies have reported that breast cancer cells are inhibited by some local anesthetics at millimolar concentration. Here, we present a comprehensive analysis of the effects of six common local anesthetics on two human breast cancer cell lines...
June 19, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29913935/adult-limb-and-breast-amputees-experience-and-descriptions-of-phantom-phenomena-a-qualitative-study
#16
Berit Björkman, Staffan Arnér, Iréne Lund, Lars-Christer Hydén
Background Phantom phenomena - pain or other sensations appearing to come from amputated body parts - are frequent consequences of amputation and can cause considerable suffering. Also, stump pain, located in the residual limb, is in the literature often related to the phantom phenomena. The condition is not specific to amputated limbs and has, to a lesser extent, been reported to be present after radical surgery in other body parts such as breast, rectum and teeth. Multi-causal theories are used when trying to understand these phenomena, which are recognized as the result of complex interaction among various parts of the central nervous system confirmed in studies using functional brain imaging techniques...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913836/phantom-phenomena-their-perceived-qualities-and-consequences-from-the-patient-s-perspective
#17
Berit Björkman, Iréne Lund, Staffan Arnér, Lars-Christer Hydén
Background and aim The curious phenomenon phantom limbs early became the object of research, and its underlying mechanisms have been discussed over the years. The complex nature of phantom phenomena makes interpretation of the results ambiguous, regarding both prevalence and the accompanying suffering. There is a lack of knowledge about how amputees experience the meaning and consequences of phantom phenomena. The present aim, therefore, was to investigate how individuals, in an interview situation, described the qualities of possible perceived phantom phenomena, and how their experience affected their lives one month after the amputation/mastectomy...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29912592/breast-cancer-during-pregnancy-results-of-maternal-and-perinatal-outcomes-in-a-single-institution-and-systematic-review-of-the-literature
#18
Natalia R Gomez-Hidalgo, Elsa Mendizabal, Laura Joigneau, Pilar Pintado, Juan De Leon-Luis
To compare the maternal and the perinatal variables of the patients with pregnancy associated breast cancer (PABC) and the pregnant patients without breast cancer (PNABC), we retrospectively included 13 PABC cases and 66.265 PNABC patients. The PABC patients presented a lower mean gestational age at their delivery and had higher induction of labour and prematurity rates. A diagnosis was performed before stage III in 77% of the cases. The overall survival was 90%; moreover, we collected 16 manuscripts when gathering data from 1581 patients with PABC...
June 18, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29911794/supplementation-with-robuvit%C3%A2-in-post-mastectomy-post-radiation-arm-lymphedema
#19
Gianni Belcaro, Mark Dugall, Roberto Cotellese, Beatrice Feragalli, Ettore Cianchetti, Maria R Cesarone
BACKGROUND: Post-mastectomy lymphedema is one of the most significant, non-life-threatening complications following breast cancer surgery and radiotherapy. Post-mastectomy post-radiotherapy (PMPR) lymphedema is related to damages to lymphatics and/or veins during/after axillary surgery and radiotherapy. The management of this condition is very challenging; the comprehensive decongestive therapy (CTD), which combines physiotherapy, self-management, and hygiene, and is currently considered the standard management (SM)...
June 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29911752/immediate-breast-reconstruction-comparative-outcome-study-of-one-stage-direct-to-implant-and-two-stage-tissue-expander-techniques
#20
Sagit Meshulam-Derazon, Tamir Shay, Sivan Lewis, Neta Adler
BACKGROUND: One-stage direct-to-implant post-mastectomy breast reconstruction has been gaining popularity over the traditional two-stage/tissue-expander approach. OBJECTIVES: To evaluate the outcome of the two post-mastectomy breast reconstruction procedures in terms of patient satisfaction. METHODS: Clinical data were collected by file review for patients who underwent mastectomy with immediate breast reconstruction at two tertiary medical centers in 2010-2013...
June 2018: Israel Medical Association Journal: IMAJ
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