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Gudrun Thuridur Hoskuldsdottir, Sigridur Bara Fjalldal, Helga Agusta Sigurjonsdottir
CONTEXT: Acromegaly is a rare disease with complications and increased mortality. The incidence and prevalence of acromegaly worldwide is not well known. OBJECTIVE: To gather information on patients diagnosed with acromegly in Iceland over 59 years. DESIGN: Information was retrospectively gathered about patients diagnosed with acromegaly from 1955 through 2013. Incidence was calculated from the total Icelandic population. SETTING/PATIENTS: Information was gathered from medical records at Landspitali National University Hospital, Iceland, housing the only endocrine department in the country, at the largest hospital outside of Reykjavik (Sjúkrahúsið á Akureyri, Akureyri Hospital) and the largest private outpatient clinic in Reykjavik, where some of the patients received follow-up care...
December 2015: Pituitary
Josef Marek
Acromegaly, if untreated, leads to numerous complications and premature death of patients. In recent years, significant changes in the treatment of acromegaly were achieved. The surgical approach was innovated, what allows completely selective removal of most microadenomas without any damage of the pituitary and safe debulking of the tumor mass in macroadenomas. Radiosurgery took the first place among irradiation methods, in our conditions it is the irradiation by the Leksell gamma knife. It allows selective irradiation of an adenoma without damaging the surrounding tissue...
2014: Casopís Lékar̆ů C̆eských
P Périmenis, J-L Wémeau, M-C Vantyghem
The frequency of hypercalciuria is increasing in western countries with an incidence of nephrolithiasis which can reach 13%. Hypercalciuria appears as an alteration of the calcium transport system (kidney, bowel, bone) which is regulated by calcitriol and parathormone. The aim of this review was to screen etiologies of hypercalciuria taking into account recent genetic advances (calcium epithelial channel and calcium sensing receptor). Hypercalciuria may be favored by nutritional causes (diet rich in calcium, sodium, carbohydrates, proteins, poor in phosphates and potassium)...
December 2005: Annales D'endocrinologie
Ph Jaquet, Ch Cortet-Rudelli, G Sassolas, I Morange-Ramos, P Chanson, Th Brue, J-M Andrieu, A Beckers, J Bertherat, F Borson-Chazot, G Brassier, Ph Caron, M Cogne, J-Ph Cottier, B Delemer, H Dufour, A Enjalbert, D Figarella-Branger, R Gaillard, M Gueydan, M Jan, J-M Kuhn, I Raingeard, J Regis, P Roger, V Rohmer, J-L Sadoul, A Saveanu, A Tabarin, N Travers, J Trouillas
UNLABELLED: From the first 198 patient files included into the French Acromegaly Registry, we analyzed 68 patients harboring a somatotroph adenoma with extrasellar extension, after exclusion of those treated by stereotactic or conventional radiotherapy. In these patients (including 37 women), aged 21-77 yr. (45.7 +/- 13.3), GH concentrations ranged from 2-260 microg/L (38.6 +/- 44.3), and IGF I from 86-967% of age-matched upper limit of normal (303 +/- 164). Maximal diameter of the adenoma at MRI was 11-36...
December 2003: Annales D'endocrinologie
Z Zdrojewicz, E Sowińska
Galanin (GAL) a 29 amino-acid peptide, is distributed in the central and peripheral nervous system, the pituitary gland, the gastrointestinal tract and also in the endocrine and exocrine pancreas. The endogenous and exogenous effects of galanin are mediated by three receptor subtypes, which are termed: GALR1, GALR2, GALR3. Galanin has a significant role in physiological and pathological processes (acromegally, diarhoea, collitis, Alzheimer's disease, oberitas depression, pituitary gland adenomas) in a human body and animals...
2000: Postȩpy Higieny i Medycyny Doświadczalnej
F Labiszewska-Jaruzelska
No abstract text is available yet for this article.
June 1968: Czasopismo Stomatologiczne
E Silinková-Málková, F Kölbel
No abstract text is available yet for this article.
1970: Acta Universitatis Carolinae. Medica
Iu I Pronin
No abstract text is available yet for this article.
1976: Vestnik Akademii Meditsinskikh Nauk SSSR
M E Molitch, G B Hieshima, S Marcovitz, I M Jackson, S Wolpert
The 'empty' sells syndrome is now a more frequent diagnosis due to the increased use of pneumoencephalography in the evaluation of the enlarged pituitary fossa. This syndrome has also been classified into a 'primary' form in which there has been no prior pituitary irradiation or surgery, and a 'secondary' form in which the empty sella is found after such procedures. Most patients with the primary empty sella syndrome are found to have normal pituitary function while about 30% have varying degrees of hypopituitarism (Neelon et al...
September 1977: Clinical Endocrinology
J Sela
Bone remodeling in pathologic conditions was studied with the scanning electron microscope (SEM). Benign and malignant ossification were examined in cases of myositis ossificans, ossifying fibroma, osteoid osteoma, and osteosarcoma, Resorption of bone due to invasion by non-ossifying tumors was found in cases of squamous cell carcinoma, adenocarcinoma, ameloblastoma, and multiple myeloma. Bone formation due to excessive production of growth hormone was studied in a case of acromegaly. Resorption of bone due to pathologic processes resembled the pattern found in surfaces which were undergoing resorption by osteoclasts...
October 20, 1977: Calcified Tissue Research
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