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Gherardo Mazziotti, Andrea Giustina, Ernesto Canalis, John P Bilezikian
Glucocorticoid-induced osteoporosis (GIO) is the most common form of secondary osteoporosis. Fractures occur in 30-50% of patients with GIO. Therefore, treatment of this disease is critical. Although patients should receive supplemental calcium and vitamin D, additional measures are necessary to prevent fractures. Estrogens and androgens may be of value in patients with hypogonadism, but bisphosphonates and teriparatide are the most effective agents in the treatment of GIO. Bisphosphonates prevent the early bone loss that follows exposure to glucocorticoids, and which has been attributed to increased resorption...
February 2009: Therapeutic Advances in Musculoskeletal Disease
Takami Miki, Kiyoshi Nakatsuka, Hiroshi Naka, Hideki Masaki, Yasuo Imanishi, Masako Ito, Masaaki Inaba, Hirotoshi Morii, Yoshiki Nishizawa
In order to evaluate the efficacy and safety of intermittent subcutaneous administration of 1-34 N-terminal peptide of human parathyroid hormone (hPTH 1-34), 100 units of hPTH 1-34 was subcutaneously injected once a week for 1 year in ten patients with primary osteoporsis (one male and nine females) with no qualitative abnormality of the bone according to the results of iliac crest biopsy performed previously, followed by a second biopsy after the end of the 1-year administration. Written consent of the patients for participation in the study was obtained...
2004: Journal of Bone and Mineral Metabolism
No abstract text is available yet for this article.
October 1957: Journal of Comparative Pathology
(no author information available yet)
No abstract text is available yet for this article.
February 3, 2003: Medical Letter on Drugs and Therapeutics
R J Noorda, J P van der Aa, P I Wuisman, E F David, P T Lips, P van der Valk
The authors report migratory transient osteoporsis of the ipsilateral hip and ankle in a patient with ostengenesis imperfecta. The diagnosis was made with modern imaging techniques (magnetic resonance imaging, bone scintigraphy, and dual energy xray absorptiometry). Histologic examination after bone biopsy of the proximal femur showed possible microfractures. The treatment consisted of a regimen of nonweightbearing. One year after onset, the patient had no symptoms and no residual evidence of transient osteoporosis on radiographic studies...
April 1997: Clinical Orthopaedics and related Research
W N Chang, C C Lui
We evaluated the therapeutic effect of combined therapy with chenodeoxycholic acid, calcium carbonate, and sodium bicarbonate on long-standing osteoporsis in three siblings (two women and one man, aged 30-38 yr) with cerebrotendinous xanthomatosis (CTX). The evaluation was based on the measurement of bone mineral density (BMD) before and after 3 years of combined therapy. Clinically, the therapeutic effect was quite limited (almost no change in BMD values), and did not parallel the marked decrease in serum cholestanol level (normalization of serum levels)...
March 1997: Journal of the Formosan Medical Association, Taiwan Yi Zhi
L M Zheng, J Z Wang
Iatrogenic osteoporosis is a very common secondary osteoporosis is found in patients treated with large dosage of glucocorticosteroid of long duration. Six cases listed in this article including 2 cases of bronchial asthma, 2 cases of bronchial asthma, 2 cases of rheumatoid arthritis, 1 case of skin disease and 1 case of callagenosis (three male patients and three female patients). The age is from 27-46. The duration of treatment of primary disease with glucocorticosteroid is 1 to 3.5 years, with the average of 1...
October 1994: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
R Duriez, J Duriez
No abstract text is available yet for this article.
1981: International Orthopaedics
R J Urban
Many changes in the neuroendocrine axis occur with healthy normal aging in humans. Women cease ovarian follicle maturation and menstrual cycles entering the estrogen-deficient state termed menopause. Although not without risk, estrogen and progesterone replacement in postmenopausal women has been shown to ameliorate the complications of lowered estradiol concentrations, such as hot flushes and osteoporsis, while improving the risk of cardiovascular complications. Aging men have lowered serum free and total testosterone concentrations and may experience a less well defined symptom complex termed andropause...
December 1992: Endocrinology and Metabolism Clinics of North America
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