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JOURNAL ARTICLE
Lu Zhang, Amy Kempf, Inga Nehlmeier, Anne Cossmann, Anja Richter, Najat Bdeir, Luise Graichen, Anna-Sophie Moldenhauer, Alexandra Dopfer-Jablonka, Metodi V Stankov, Etienne Simon-Loriere, Sebastian R Schulz, Hans-Martin Jäck, Luka Čičin-Šain, Georg M N Behrens, Christian Drosten, Markus Hoffmann, Stefan Pöhlmann
BA.2.86, a recently identified descendant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2 sublineage, contains ∼35 mutations in the spike (S) protein and spreads in multiple countries. Here, we investigated whether the virus exhibits altered biological traits, focusing on S protein-driven viral entry. Employing pseudotyped particles, we show that BA.2.86, unlike other Omicron sublineages, enters Calu-3 lung cells with high efficiency and in a serine- but not cysteine-protease-dependent manner...
January 5, 2024: Cell
#22
REVIEW
Amneet Bajwa, Alma Habib, Adam S Kittai
PURPOSE OF REVIEW: This review presents recently published clinical trial data and ongoing investigations regarding the treatment of Richter's transformation (RT). RECENT FINDINGS: Recently, numerous approaches have been investigated for the treatment of RT including: traditional chemoimmunotherapy regimens combined with targeted agents such as BTKi and BCL2i; immunotherapy combined with targeted agents; non-covalent BTKis; bispecific T cell engagers; and CART therapy...
April 2024: Current Hematologic Malignancy Reports
#23
JOURNAL ARTICLE
Hua Wang, Wei-Hong Yan, Jun-Jie Sun, Mei Dong, Nan Zhang, Tong Liu, Nian-Peng Song, Lin Zhong
BACKGROUND: Richter's syndrome (RS) defines the transformation of chronic lymphocytic leukemia into high-grade lymphoma, which usually involves lymph nodes and bone marrow. Extranodal involvement of the heart is an extremely rare condition. Patients with heart involvement tended to have a low response to chemotherapy and relative poor prognosis. The transformation process of RS is often insidious and nonspecific making it challenging to diagnose. CASE PRESENTATION: A 64-year-old woman wih a history of chronic lymphocytic leukemia (CLL) presented with intermittent chest pain and was diagnosed with non-ST-elevation myocardial infarction (NSTEMI)...
December 21, 2023: BMC Cardiovascular Disorders
#24
Mário Sousa-Pimenta, Ângelo Martins, José Mário Mariz, Pedro Berraondo
INTRODUCTION AND AIMS: Richter syndrome (RS) represents the clonal evolution of chronic lymphocytic leukemia with histological transformation into a high-grade B cell lymphoma (diffuse large B cell lymphoma - DLBCL) or Hodgkin lymphoma. Considering that RS is an uncommon condition with poor prognosis, few high-quality evidence is available. To overcome this unmet need, this meta-analysis aimed to pool efficacy of early clinical trials in Richter syndrome (DLBCL subtype). METHODS: MEDLINE, Scopus and Web of Science were searched up to May of 2023 to identify clinical trials decoying efficacy...
2023: Frontiers in Immunology
#25
JOURNAL ARTICLE
Anja Tüchler, Antoine De Pauw, Corinna Ernst, Amélie Anota, Inge M M Lakeman, Julia Dick, Nienke van der Stoep, Christi J van Asperen, Monika Maringa, Natalie Herold, Britta Blümcke, Robert Remy, Anke Westerhoff, Denise J Stommel-Jenner, Eléonore Frouin, Lisa Richters, Lisa Golmard, Nadine Kütting, Chrystelle Colas, Barbara Wappenschmidt, Kerstin Rhiem, Peter Devilee, Dominique Stoppa-Lyonnet, Rita K Schmutzler, Eric Hahnen
BACKGROUND: Breast cancer (BC) risk prediction models consider cancer family history (FH) and germline pathogenic variants (PVs) in risk genes. It remains elusive to what extent complementation with polygenic risk score (PRS) and non-genetic risk factor (NGRFs) data affects individual intensified breast surveillance (IBS) recommendations according to European guidelines. METHODS: For 425 cancer-free women with cancer FH (mean age 40·6 years, range 21-74), recruited in France, Germany and the Netherlands, germline PV status, NGRFs, and a 306 variant-based PRS (PRS306 ) were assessed to calculate estimated lifetime risks (eLTR) and estimated 10-year risks (e10YR) using CanRisk...
November 29, 2023: Breast: Official Journal of the European Society of Mastology
#26
JOURNAL ARTICLE
Suna Jung, Sneha Shah, Geongoo Han, Joel D Richter
Fragile X syndrome (FXS) is a neurodevelopmental disorder that is often modeled in Fmr1 knockout mice where the RNA-binding protein FMRP is absent. Here, we show that in Fmr1-deficient mice, RNA mis-splicing occurs in several brain regions and peripheral tissues. To assess molecular mechanisms of splicing mis-regulation, we employed N2A cells depleted of Fmr1. In the absence of FMRP, RNA-specific exon skipping events are linked to the splicing factors hnRNPF, PTBP1, and MBNL1. FMRP regulates the translation of Mbnl1 mRNA as well as Mbnl1 RNA auto-splicing...
December 2023: PLoS Biology
#27
JOURNAL ARTICLE
Thomas Chatzikonstantinou, Lydia Scarfò, Georgios Karakatsoulis, Eva Minga, Dimitra Chamou, Gloria Iacoboni, Jana Kotaskova, Christos Demosthenous, Lukas Smolej, Stephen Mulligan, Miguel Alcoceba, Salem Al-Shemari, Thérèse Aurran-Schleinitz, Francesca Bacchiarri, Mar Bellido, Fontanet Bijou, Anne Calleja, Angeles Medina, Mehreen Ali Khan, Ramona Cassin, Sofia Chatzileontiadou, Rosa Collado, Amy Christian, Zadie Davis, Maria Dimou, David Donaldson, Gimena Dos Santos, Barbara Dreta, Maria Efstathopoulou, Shaimaa El-Ashwah, Alicia Enrico, Alberto Fresa, Sara Galimberti, Andrea Galitzia, Rocío García-Serra, Eva Gimeno, Isabel González-Gascón-Y-Marín, Alessandro Gozzetti, Valerio Guarente, Romain Guieze, Ajay Gogia, Ritu Gupta, Sean Harrop, Eleftheria Hatzimichael, Yair Herishanu, José-Ángel Hernández-Rivas, Luca Inchiappa, Ozren Jaksic, Susanne Janssen, Elżbieta Kalicińska, Laribi Kamel, Volkan Karakus, Arnon P Kater, Bonnie Kho, Maria Kislova, Eliana Konstantinou, Maya Koren-Michowitz, Ioannis Kotsianidis, Robert J Kreitman, Jorge Labrador, Deepesh Lad, Mark-David Levin, Ilana Levy, Thomas Longval, Alberto Lopez-Garcia, Juan Marquet, Lucia Martin-Rodríguez, Marc Maynadié, Stanislava Maslejova, Carlota Mayor-Bastida, Biljana Mihaljevic, Ivana Milosevic, Fatima Miras, Riccardo Moia, Marta Morawska, Roberta Murru, Uttam Kumar Nath, Almudena Navarro-Bailón, Ana C Oliveira, Jacopo Olivieri, David Oscier, Irina Panovska-Stavridis, Maria Papaioannou, Tomas Papajík, Zuzana Kubova, Punyarat Phumphukhieo, Cheyenne Pierie, Anna Puiggros, Lata Rani, Gianluigi Reda, Gian Matteo Rigolin, Rosa Ruchlemer, Marcos Daniel de Deus Santos, Mattia Schipani, Annett Schiwitza, Yandong Shen, Martin Simkovic, Svetlana Smirnova, Dina Sameh Abdelrahman Soliman, Martin Spacek, Tamar Tadmor, Kristina Tomic, Eric Tse, Theodoros Vassilakopoulos, Andrea Visentin, Candida Vitale, Julia von Tresckow, George Vrachiolias, Vojin Vukovic, Renata Walewska, Ewa Wasik-Szczepanek, Zhenshu Xu, Munci Yagci, Lucrecia Yañez, Mohamed Yassin, Jana Zuchnicka, Maria Angelopoulou, Darko Antic, Bella Biderman, Mark Catherwood, Rainer Claus, Marta Coscia, Antonio Cuneo, Fatih Demirkan, Blanca Espinet, Gianluca Gaidano, Olga B Kalashnikova, Luca Laurenti, Eugene Nikitin, Gerassimos A Pangalis, Panagiotis Panagiotidis, Viola Maria Popov, Sarka Pospisilova, Paolo Sportoletti, Niki Stavroyianni, Constantine Tam, Livio Trentin, Anastasia Chatzidimitriou, Francesc Bosch, Michael Doubek, Paolo Ghia, Kostas Stamatopoulos
BACKGROUND: Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, the impact of CLL-related risk factors and CLL-directed treatment is still unclear and represents the focus of this work. METHODS: We conducted a retrospective international multicenter study to assess the incidence of OMs and detect potential risk factors in 19,705 patients with CLL, small lymphocytic lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 and 2016...
November 2023: EClinicalMedicine
#28
JOURNAL ARTICLE
Alena Chalupka, Lukas Richter, Ali Chakeri, Ziad El-Khatib, Verena Theiler-Schwetz, Christian Trummer, Robert Krause, Peter Willeit, Bernhard Benka, John P A Ioannidis, Stefan Pilz
INTRODUCTION: Evidence is limited on the effectiveness of a fourth vaccine dose against coronavirus disease 2019 (COVID-19) in populations with prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. We estimated the risk of COVID-19 deaths and SARS-CoV-2 infections according to vaccination status in previously infected individuals in Austria. METHODS: This is a nationwide retrospective observational study. We calculated age and gender adjusted Cox proportional hazard ratios (HRs) of COVID-19 deaths (primary outcome) and SARS-CoV-2 infections (secondary outcome) from 1 November to 31 December 2022, primarily comparing individuals with four versus three vaccine doses...
November 30, 2023: European Journal of Clinical Investigation
#29
REVIEW
Adree Khondker, Ihtisham Ahmad, Kellie Kim, Shamir Malik, Jin K Kim, Michael Chua, Juliane Richter, Justin Yh Chan, Linda A Baker, Armando J Lorenzo, Mandy Rickard
BACKGROUND: Children with prune belly syndrome (PBS) are at higher risk of developing kidney dysfunction and requiring kidney replacement therapy (KRT). While studies have described surgical and survival outcomes in these populations, there has yet to be a focused synthesis of evidence regarding kidney outcomes in this population. Here, the focus of this scoping review was to highlight knowledge gaps and report standards on kidney outcomes in PBS of all ages. METHODS: Following scoping review methodology, EMBASE, MEDLINE, and Scopus were searched for peer-reviewed literature that describe kidney outcomes in PBS...
November 16, 2023: Pediatric Nephrology
#30
REVIEW
Feven W Getaneh, Rishabh Simhal, Tamir Sholklapper, Emilie Melvin, Charles Scott Dorris, Jiling Chou, Lee A Richter, Alexis Dieter
INTRODUCTION AND HYPOTHESIS: To our knowledge, there are no evidence-based recommendations regarding the optimal prophylactic antibiotic regimen for intradetrusor onabotulinum toxin type A (BTX) injections. This systematic review and meta-analysis was aimed at investigating the optimal prophylactic antibiotic regimen to decrease urinary tract infection (UTI) in patients undergoing BTX for overactive bladder syndrome (OAB). METHODS: A systematic search of MEDLINE, Embase, CINAHL, and Web of Science was conducted from inception through 30 June 2022...
November 8, 2023: International Urogynecology Journal
#31
JOURNAL ARTICLE
Caroline G Richter, Cláudia Cardoso-Martins, Carolyn B Mervis
We examined the cognitive, language, and instructional predictors of early word-reading ability in a sample of children with Williams syndrome longitudinally. At Time 1, sixty-nine 6-7-year-olds (mean age = 6.53 years) completed standardized measures of phonological awareness, visual-spatial perception, vocabulary, and overall intellectual ability. Word-reading instruction type was classified as (systematic) Phonics ( n = 35) or Other ( n = 34). At Time 2, approximately three years later (mean age = 9.47 years), children completed a standardized assessment of single-word reading ability...
October 2023: Reading and Writing
#32
JOURNAL ARTICLE
Minghao Li, Susan Richter, Hermine Mohr, Stephan Drukewitz, Isabel Poser, Daniela Stanke, Bruna Calsina, Angel M Martinez-Montes, Marcus Quinkler, Henri J L M Timmers, Svenja Nölting, Felix Beuschlein, Hanna Remde, Giuseppe Opocher, Elena Rapizzi, Karel Pacak, Christina Pamporaki, Mercedes Robledo, Longfei Liu, Jingjing Jiang, Stefan R Bornstein, Graeme Eisenhofer, Stephanie M J Fliedner, Nicole Bechmann
The biochemical phenotype of paragangliomas (PGLs) is highly dependent on the underlying genetic background and tumor location. PGLs at extra-adrenal locations usually do not express phenylethanolamine N-methyltransferase (PNMT), the enzyme required for epinephrine production, which was explained by the absence of glucocorticoids. PGLs with pathogenic variants (PVs) in Harvey rat sarcoma viral oncogene homolog (HRAS) can occur in or outside of the adrenal, but always synthesize epinephrine independently of the localization...
December 1, 2023: Endocrine-related Cancer
#33
JOURNAL ARTICLE
Brian T Hill, Shuo Ma, Clive S Zent, Andrea M Baran, Danielle S Wallace, Anjali S Advani, Allison M Winter, Jane N Winter, Leo I Gordon, Reem Karmali, Jane L Liesveld, Deborah A Mulford, Chris Rowland, Andrew Bui, Peter Sportelli, Hari P Miskin, Michael S Weiss, Jonathan W Friedberg, Paul M Barr
Many patients with chronic lymphocytic leukemia (CLL) will develop treatment resistance to Bruton's tyrosine kinase (BTK) inhibitors. Phosphatidylinositol-3-kinase (PI3K) inhibitors, including umbralisib, have significant clinical activity in relapsed/refractory CLL, but prolonged exposure is associated with potential toxicities. Due to the synergistic anti-tumor effects of combined PI3K and BCL-2 inhibition, we sought to explore the feasibility of response-adapted, time-limited therapy to optimize disease control while mitigating the risks of prolonged treatment...
October 23, 2023: Blood Advances
#34
REVIEW
Benjamin Luchting, Uta Behrends, Bianca Eigner, Silvia Stojanov, Cordula Warlitz, Matthias Haegele, Eva Neuwirth, Lorenz Mihatsch, Hans Peter Richter
BACKGROUND: Multimodal pain therapy usually take place in the context of group therapy lasting several weeks and is based on a generally activating approach. Due to the specificity of stress intolerance with postexertional malaise (PEM) in patients with postviral syndromes, physical as well as psychological overload must be urgently avoided in these cases; however, these aspects can only be insufficiently considered in current medical pain therapy concepts. METHODS: Summary of the current literature and presentation of clinical characteristics as well as presentation of a model project for a multimodal pain therapy in postviral syndromes with PEM...
October 20, 2023: Der Schmerz
#35
REVIEW
B Dalkıran, B Beydoğan, A G Erdemir, S A Düzgün, E Gümeler, I S İdilman, M R Onur, E Akpınar
In the southeastern part of Turkey, two earthquakes measuring 7.7 and 7.8 on the Richter scale occurred within 9 h on 6 February 2023, causing 120,000 injuries and over 50,000 deaths. Evacuees were transferred to various secondary and tertiary hospitals as the health system and hospitals in the affected region were affected by the earthquake. Injuries were mostly caused by blunt trauma and/or prolonged bruising under rubble. The severity and pattern of traumatic injuries in earthquake victims differed from other trauma patients who were not affected by an earthquake...
October 7, 2023: Clinical Radiology
#36
JOURNAL ARTICLE
Kira Griffiths, Maria Ruiz Mellado, Raymond Chung, John Lally, Grant McQueen, Kyra-Verena Sendt, Amy Gillespie, Muhammad Ibrahim, Alex Richter, Adrian Shields, Mark Ponsford, Stephen Jolles, John Hodsoll, Thomas Pollak, Rachel Upthegrove, Alice Egerton, James H MacCabe
BACKGROUND AND HYPOTHESIS: Use of clozapine in treatment-resistant schizophrenia is often limited due to risk of adverse effects. Cross-sectional associations between clozapine treatment and low immunoglobulin levels have been reported, however prospective studies are required to establish temporal relationships. We tested the hypothesis that reductions in immunoglobulin levels would occur over the first 6 months following initiation of clozapine treatment. Relationships between immunoglobulin levels and symptom severity over the course of clozapine treatment were also explored...
October 11, 2023: Brain, Behavior, and Immunity
#37
JOURNAL ARTICLE
Heike A Bischoff-Ferrari, Michael Gagesch, Dai-Hua Tsai, Clara Richter, Patricia Lanz, Patrick Sidler, Uenal Can, Dagmar I Keller, Markus Minder, Bettina von Rickenbach, Ali Yildirim-Aman, Katharina Geiling, Gregor Freystaetter
BACKGROUND: The growing number of older and oldest-old patients often present in the emergency room (ER) with undiagnosed geriatric syndromes posing them at high risk for complications in acute care. OBJECTIVE: To develop and validate an ER screening tool (ICEBERG) to capture 9 geriatric domains of risk in older patients. DESIGN SETTING AND PARTICIPANTS: For construct validity we performed a chart-based study in 129 ER patients age 70 years and older admitted to acute geriatric care (pilot 1)...
2023: Frontiers in Medicine
#38
REVIEW
Andrea Corujo Rodriguez, Ellen Richter, Stephanie Opunsunju Ibekwe, Tina Shah, Abimbola O Faloye
Postcardiotomy shock (PCS) is generally described as the inability to separate from cardiopulmonary bypass due to ineffective cardiac output after cardiotomy, which is caused by a primary cardiac disorder, resulting in inadequate tissue perfusion. Postcardiotomy shock occurs in 0.5% to 1.5% of contemporary cardiac surgery cases, and is accompanied by an in-hospital mortality of approximately 67%. In the last 2 decades, the incidence of PCS has increased, likely due to the increased age and baseline morbidity of patients requiring cardiac surgery...
December 2023: Journal of Cardiothoracic and Vascular Anesthesia
#39
JOURNAL ARTICLE
Minghao Li, Susan Richter, Hermine Mohr, Stephan Drukewitz, Isabel Poser, Daniela Stanke, Bruna Calsina, Angel M Martinez-Montes, Marcus Quinkler, Henri Jlm Timmers, Svenja Nölting, Felix Beuschlein, Hanna Remde, Giuseppe Opocher, Elena Rapizzi, Karel Pacak, Christina Pamporaki, Mercedes Robledo, Longfei Liu, Jingjing Jiang, Stefan R Bornstein, Graeme Eisenhofer, Stephanie M J Fliedner, Nicole Bechmann
The biochemical phenotype of paragangliomas (PGLs) is highly dependent on the underlying genetic background and tumor location. PGLs at extra-adrenal locations usually do not express phenylethanolamine N-methyltransferase (PNMT), the enzyme required for epinephrine production, which was explained by the absence of glucocorticoids. PGLs with pathogenic variants (PVs) in Harvey rat sarcoma viral oncogene homolog (HRAS) can occur in or outside of the adrenal, but always synthesize epinephrine independently of the localization...
September 1, 2023: Endocrine-related Cancer
#40
REVIEW
Dimitrios Farmakis, Dimitrios Richter, Genovefa Chronopoulou, George Goumas, Dimitrios Kountouras, Anna Mastorakou, Georgios Papingiotis, George Hahalis, Konstantinos Tsioufis
Troponin I and T as cardiac-specific biomarkers are highly useful tools not only in the diagnosis of acute coronary syndromes but also as independent predictors of several other clinical conditions. High-sensitivity cardiac troponin (hs-cTn) assays allow the detection of considerably low concentrations of cardiac troponin in apparently healthy and asymptomatic individuals, being a candidate tool for cardiovascular risk stratification in the general population. A group of Greek experts summarized the bulk of evidence regarding the use of hs-cTnI as a predictor of cardiovascular events and mortality in apparently healthy individuals and its additive value on top of existing risk stratification methods...
September 22, 2023: Hellenic Journal of Cardiology: HJC
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