Anna L Peljto, Rachel Z Blumhagen, Avram D Walts, Jonathan Cardwell, Julia Powers, Tamera J Corte, Joanne L Dickinson, Ian Glaspole, Yuben P Moodley, Martina Koziar Vasakova, Elisabeth Bendstrup, Jesper R Davidsen, Raphael Borie, Bruno Crestani, Philippe Dieude, Francesco Bonella, Ulrich Costabel, Gunnar Gudmundsson, Seamas C Donnelly, Jim Egan, Michael T Henry, Michael P Keane, Marcus P Kennedy, Cormac McCarthy, Aoife N McElroy, Joshua A Olaniyi, Katherine M A O'Reilly, Luca Richeldi, Paolo M Leone, Venerino Poletti, Francesco Puppo, Sara Tomassetti, Valentina Luzzi, Nurdan Kokturk, Nesrin Mogulkoc, Christine A Fiddler, Nikhil Hirani, Gisli Jenkins, Toby M Maher, Philip L Molyneaux, Helen Parfrey, Rebecca Braybrooke, Timothy S Blackwell, Peter D Jackson, Steven D Nathan, Mary K Porteous, Kevin K Brown, Jason D Christie, Harold R Collard, Oliver Eickelberg, Elena E Foster, Kevin F Gibson, Marilyn Glassberg, Daniel Kass, Jonathan A Kropski, David Lederer, Angela L Linderholm, Jim Loyd, Susan K Mathai, Sydney B Montesi, Imre Noth, Justin M Oldham, Amy J Palmisciano, Cristina A Reichner, Mauricio Rojas, Jesse Roman, Neil Schluger, Barry S Shea, Jeffrey J Swigris, Paul J Wolters, Yingze Zhang, Cecilia M A Prele, Juan I Enghelmayer, Maria Otaola, Christopher J Ryerson, Mauricio Salinas, Martina Sterclova, Tewodros H Gebremariam, Marjukka Myllärniemi, Roberto Carbone, Haruhiko Furusawa, Masaki Hirose, Yoshikazu Inoue, Yasunari Miyazaki, Ken Ohta, Shin Ohta, Tsukasa Okamoto, Dong Soon Kim, Annie Pardo, Moises Selman, Alvaro U Aranda, Moo Suk Park, Jong Sun Park, Jin Woo Song, Maria Molina-Molina, Lurdes Planas-Cerezales, Gunilla Westergren-Thorsson, Albert V Smith, Ani W Manichaikul, John S Kim, Stephen S Rich, Elizabeth C Oelsner, R Graham Barr, Jerome I Rotter, Josee Dupuis, George O'Connor, Ramachandran S Vasan, Michael H Cho, Edwin K Silverman, Marvin I Schwarz, Mark P Steele, Joyce S Lee, Ivana V Yang, Tasha E Fingerlin, David A Schwartz
RATIONALE: Idiopathic pulmonary fibrosis is a rare, irreversible, and progressive disease of the lungs. Common genetic variants, in addition to non-genetic factors, have been consistently associated with IPF. Rare variants identified by candidate gene, family-based, and exome studies have also been reported to associate with IPF. However, the extent to which rare variants genome-wide may contribute to the risk of IPF remains unknown. OBJECTIVES: We used whole-genome sequencing to investigate the role of rare variants, genome-wide, on IPF risk...
January 5, 2023: American Journal of Respiratory and Critical Care Medicine