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https://www.readbyqxmd.com/read/29768511/12-year-trends-in-cardiovascular-risk-factors-2002-2005-through-2011-2014-in-patients-with-cardiovascular-diseases-tehran-lipid-and-glucose-study
#1
SeyedHossein Rabani, Mahsa Sardarinia, Samaneh Akbarpour, Fereidoun Azizi, Davood Khalili, Farzad Hadaegh
BACKGROUND: To examine the trend of cardiovascular diseases (CVD) risk factors among a Middle Eastern population with prevalent CVD during a median follow up of 12 years. METHODS: Patients with prevalent CVD (n = 282, men = 167), with a mean age of 60.76 years were evaluated in four study phases of the TLGS (Tehran lipid glucose study), 2002-2005, 2005-2008, 2008-2011, and 2011-2014. Trends of CVD risk factors were estimated using generalized estimation equation (GEE) models, by adjusting for gender, age and propensity scores...
2018: PloS One
https://www.readbyqxmd.com/read/29747326/-current-status-and-the-consistency-analysis-of-using-two-criteria-for-decision-making-of-aspirin-use-for-the-primary-prevention-of-ischemic-cardiovascular-disease-in-outpatients
#2
H J Zuo, L Q Deng, J W Wang
Objective: To compare the consistency and accuracy of using 2 criteria for decision making of aspirin use for the primary prevention of ischemic cardiovascular disease (ISCVD) and explore the current status and related factors of aspirin use for the primary prevention of ISCVD in Chinese outpatients. Methods: This cross-sectional study enrolled 3 018 outpatients with hypertension, diabetes, or hypercholesterolemia, who visited the General Practice (GP) clinics of Anzhen hospital in Beijing from September to December 2015 were enrolled in...
April 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29743218/living-in-cold-spot-communities-is-associated-with-poor-health-and-health-quality
#3
Winston Liaw, Alex H Krist, Sebastian T Tong, Roy Sabo, Camille Hochheimer, Jennifer Rankin, David Grolling, Jene Grandmont, Andrew W Bazemore
PURPOSE: Little is known about incorporating community data into clinical care. This study sought to understand the clinical associations of cold spots (census tracts with worse income, education, and composite deprivation). METHODS: Across 12 practices, we assessed the relationship between cold spots and clinical outcomes (obesity, uncontrolled diabetes, pneumonia vaccination, cancer screening-colon, cervical, and prostate-and aspirin chemoprophylaxis) for 152,962 patients...
May 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29742684/myocardial-injury-after-noncardiac-surgery-incidence-and-predictors-from-a-prospective-observational-cohort-study-at-an-indian-tertiary-care-centre
#4
Rubin George, Vidya P Menon, Fabia Edathadathil, Sabarish Balachandran, Merlin Moni, Dipu Sathyapalan, Preetha Prasanna, Gokuldas S, Jerry Paul, Chandrababu K K, Lakshmi Kumar, Ashok Pillai
Asymptomatic myocardial injury following noncardiac surgery (MINS) is an independent predictor of 30-day mortality and may go unrecognized based on standard diagnostic definition for myocardial infarction (MI). Given lack of published research on MINS in India, our study aims to determine incidence of MINS in patients undergoing noncardiac surgery at our tertiary care hospital, and evaluate the clinical characteristics including 30-day outcome.The prospective observational study included patients >65 years or >45 years with either hypertension (HTN), diabetes mellitus (DM), coronary artery disease (CAD), cerebrovascular accident (CVA), or peripheral arterial disease undergoing noncardiac surgery...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29739273/angiogenic-dysregulation-in-pregnancy-related-hypertension-a-role-for-metformin
#5
Nerolen Soobryan, Saravanakumar Murugesan, Arunagiri Pandiyan, Jagidesa Moodley, Irene Mackraj
In the face of escalating maternal and fetal health threats, hypertensive pregnancy disorders (HPDs) is one of the leading cause of maternal and fetal morbidity and mortality. The range of HPDs include white-coat hypertension, chronic hypertension, gestational hypertension, mild-to-moderate and severe preeclampsia and eclampsia. Current evidence implicates an imbalance of circulating anti- and angiogenic factors in HPDs emanating from the placental vasculature, impacting on angiogenesis. Delivery of the fetus is thus far the only curative measure, albeit with increased risk...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29731992/response-to-clopidogrel-is-associated-with-early-neurological-deterioration-after-acute-ischemic-stroke
#6
Xingyang Yi, Jing Lin, Yanfen Wang, Ju Zhou, Qiang Zhou, Chun Wang
Purpose: The relationship between response to clopidogrel and early neurological deterioration (END) after acute ischemic stroke (IS) is not well defined. The aim of present study was to evaluate the associations of clopidogrel resistance (CR) with END, and stratified analyze the effectiveness of clopidogrel alone and clopidogrel plus aspirin for the prevention of END. Results: A total of 375 patients, 144 patients were received clopidogrel alone, 231 patients took clopidogrel plus aspirin...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29728092/cytoreductive-treatment-patterns-among-us-veterans-with-polycythemia-vera
#7
Shreekant Parasuraman, Jingbo Yu, Dilan Paranagama, Sulena Shrestha, Li Wang, Onur Baser, Robyn Scherber
BACKGROUND: Polycythemia vera (PV) is a myeloproliferative neoplasm associated with increased thrombotic and cardiovascular risk, which are key contributors to patient morbidity and mortality. The Veterans Health Administration (VHA) is the largest integrative health network in the United States. Available data concerning patients with PV in this population are limited. METHODS: This retrospective observational study evaluated the characteristics, management, and outcomes of patients with PV in the VHA Medical SAS® Dataset (October 1, 2005, to September 30, 2012)...
May 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29723426/cyp2c19-or-cyp3a5-genotyping-does-not-predict-clinical-response-to-clopidogrel
#8
Fayna Rodríguez-González, Efren Martínez-Quintana, Pedro Saavedra, José M Medina-Gil, Marta Riaño, Paloma Garay-Sánchez, Antonio Tugores
Along with aspirin, clopidogrel has been a widely used antiplatelet therapeutic regimen. Although generally well tolerated, its efficacy varies among individuals, with the main hypothesis that its bioavailability relies on its bioconversion to the active compound, which, in turn, depends on the genetic background and/or interactions with other drugs. To determine which factors influenced response in our patients, 368 patients receiving combined antiaggregation therapy with aspirin and clopidogrel were followed for 1 year to record 30 novel cardiovascular acute events...
May 3, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29720539/its-reticulated-the-liver-at-the-heart-of-atherosclerosis
#9
Prabhakara R Nagareddy, Sunil K Noothi, Michelle Christine Flynn, Andrew Murphy
Platelets play a critical role in both the initiation and progression of atherosclerosis, and even more so in the ensuing atherothrombotic complications. Low-dose aspirin remains the mainstay of antiplatelet therapy in high-risk patients by reducing the risk of myocardial ischemia (MI), stroke, or death due to cardiovascular disease (CVD). However, antiplatelet therapies lose their efficacy in people with diabetes mellitus (DM), increasing the risk of future atherothrombotic events. The molecular mechanisms that promote platelet hyperactivity remain unclear but could be due to glycation-induced conformational changes of platelet membranes resulting in impaired aspirin entry, or less-efficient acetylation/compensatory increase in COX-2 expression in newborn platelets...
May 2, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29691782/cost-effectiveness-of-aspirin-adherence-for-secondary-prevention-of-cardiovascular-events
#10
Laurence M Djatche, Stefan Varga, Robert D Lieberthal
BACKGROUND: Suboptimal adherence to aspirin therapy for secondary prevention of cardiovascular (CV) events is an important public health problem. Prior studies have demonstrated non-adherent patients are at higher risk of experiencing CV events. OBJECTIVES: This study aimed to estimate the clinical and economic outcomes of aspirin non-adherence in patients with a prior primary CV event. METHODS: We developed a Markov model to estimate the cost-effectiveness of aspirin adherence from a generic US managed care payer perspective over a 5-year time horizon...
April 24, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29686158/erratum-aspirin-for-the-primary-prevention-of-cardiovascular-events-a-systematic-review-and-meta-analysis-comparing-patients-with-and-without-diabetes-diabetes-care-2009-32-2300-2306
#11
Andrew D Calvin, Niti R Aggarwal, Mohammad Hassan Murad, Qian Shi, Mohamed B Elamin, Jeffrey B Geske, M Merce Fernandez-Balsells, Felipe N Albuquerque, Julianna F Lampropulos, Patricia J Erwin, Steven A Smith, Victor M Montori
No abstract text is available yet for this article.
April 23, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29685512/causes-and-outcomes-of-finger-ischemia-in-hospitalized-patients-in-the-intensive-care-unit
#12
Gregory J Landry, Courtney J Mostul, Daniel S Ahn, Bryant J McLafferty, Timothy K Liem, Erica L Mitchell, Enjae Jung, Cherrie Z Abraham, Amir F Azarbal, Robert B McLafferty, Gregory L Moneta
OBJECTIVE: Vascular surgeons may be consulted to evaluate hospitalized patients with finger ischemia. We sought to characterize causes and outcomes of finger ischemia in intensive care unit (ICU) patients. METHODS: All ICU patients who underwent evaluation for finger ischemia from 2008 to 2015 were reviewed. All were evaluated with finger photoplethysmography. The patients' demographics, comorbidities, ICU care (ventilator status, arterial lines, use of vasoactive medications), finger amputations, and survival were also recorded...
April 20, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29683306/maternity-care-update-prenatal-care-and-specific-conditions
#13
Andrew Smith, Wendy B Barr, Erin Bassett-Novoa, Nicholas LeFevre
Early initiation of prenatal care is associated with improved health outcomes for women and newborns. An essential element of prenatal care is determining the estimated due date, ideally using a first-trimester ultrasound. Laboratory tests should be obtained to screen for conditions that can affect pregnancy. Routine immunizations for all pregnant women include influenza vaccine; tetanus toxoid, reduced diphtheria, acellular pertussis (Tdap) vaccine. All women should be screened for gestational diabetes mellitus in midpregnancy...
April 2018: FP Essentials
https://www.readbyqxmd.com/read/29671538/stable-coronary-artery-disease-treatment
#14
Michael M Braun, William A Stevens, Craig H Barstow
Stable coronary artery disease refers to a reversible supply/demand mismatch related to ischemia, a history of myocardial infarction, or the presence of plaque documented by catheterization or computed tomography angiography. Patients are considered stable if they are asymptomatic or their symptoms are controlled by medications or revascularization. Treatment involves risk factor management, antiplatelet therapy, and antianginal medications. Tobacco cessation, exercise, and weight loss are the most important lifestyle modifications...
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29664030/do-practice-gaps-exist-in-evidence-based-medication-prescription-at-hospital-discharge-in-patients-undergoing-coronary-artery-bypass-surgery-coronary-angioplasty
#15
Pradeep Pereira, Aditya Kapoor, Archana Sinha, Surendra K Agarwal, Shantanu Pande, Roopali Khanna, Nilesh Srivastava, Sudeep Kumar, Naveen Garg, Satyendra Tewari, Pravin Goel
Background & objectives: Prescription patterns of guideline-directed medical therapy (GDMT) after coronary artery bypass surgery [coronary artery bypass graft (CABG)] and percutaneous coronary intervention (PCI) at hospital discharge are often not optimal. In view of scarce data from the developing world, a retrospective analysis of medication advice to patients following CABG and PCI was conducted. Methods: Records of 5948 patients (post-PCI: 5152, post-CABG: 796) who underwent revascularization from 2010 to 2014 at a single tertiary care centre in north India were analyzed...
December 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29661588/impact-of-metabolic-diseases-drugs-and-dietary-factors-on-prostate-cancer-risk-recurrence-and-survival-a-systematic-review-by-the-european-association-of-urology-section-of-oncological-urology
#16
REVIEW
Riccardo Campi, Sabine D Brookman-May, Jose Daniel Subiela Henríquez, Bülent Akdoğan, Maurizio Brausi, Tobias Klatte, Johan F Langenhuijsen, Estefania Linares-Espinos, Martin Marszalek, Morgan Roupret, Christian G Stief, Alessandro Volpe, Andrea Minervini, Oscar Rodriguez-Faba
CONTEXT: To date, established risk factors for prostate cancer (PCa) are limited to age, race, family history, and certain genetic polymorphisms. Despite great research efforts, available evidence on potentially modifiable risk factors is conflicting. Moreover, most studies on PCa risk factors did not consider the impact of prostate-specific antigen (PSA) testing on PCa diagnosis. OBJECTIVE: To provide a detailed overview of the latest evidence on the role of metabolic diseases, drugs, and dietary factors for risk of PCa incidence, recurrence, and survival in men exposed to PSA testing...
April 13, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29656179/novel-reno-protective-mechanism-of-aspirin-involves-h2ak119-monoubiquitination-and-set7-in-preventing-type-1-diabetic-nephropathy
#17
Santosh Kumar Goru, Anil Bhanudas Gaikwad
BACKGROUND: Even after several novel therapeutic approaches, the number of people with diabetic nephropathy (DN) still continues to increase globally, this suggest to find novel therapeutic strategies to prevent it completely. Recent reports, are indicating the ubiquitin proteasome system alterations in DN. Recently, we also showed that, histone H2AK119 mono-ubiquitination (H2AK119-Ub) found to regulate Set7, a key epigenetic enzyme in the development of renal fibrosis under type 1 diabetic condition...
December 2, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29624871/utilization-of-aspirin-and-statin-in-management-of-coronary-artery-disease-in-patients-with-cirrhosis-undergoing-liver-transplant-evaluation
#18
Samarth S Patel, Luis Guzman, Fei-Pi Lin, Taylor Pence, Trevor Reichman, Binu John, Francesco S Celi, Erika Liptrap, Chandra Bhati, Mohammad S Siddiqui
Coronary artery disease (CAD) assessment is vital part of liver transplantation (LT) evaluation as it allows for identification and medical optimization prior to transplantation. Although aspirin and statins are standard of care for CAD, they are not universally used in cirrhosis due to concerns of adverse events. METHODS: Per protocol, coronary angiography was performed as part of LT evaluation in all patients over the age of 50 years or with CAD risk factors even if they were younger than 50...
April 6, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29610837/cardiovascular-disease-and-risk-management-review-of-the-american-diabetes-association-standards-of-medical-care-in-diabetes-2018
#19
James J Chamberlain, Eric L Johnson, Sandra Leal, Andrew S Rhinehart, Jay H Shubrook, Lacie Peterson
Description: The American Diabetes Association (ADA) annually updates its Standards of Medical Care in Diabetes to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of patients with diabetes. Methods: For the 2018 standards, the ADA Professional Practice Committee searched MEDLINE through November 2017 to add, clarify, or revise recommendations on the basis of new evidence...
April 3, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29582106/trends-and-variations-in-the-prescribing-of-secondary-preventative-cardiovascular-therapies-for-non-st-elevation-myocardial-infarction-nstemi-in-malaysia
#20
Padmaa Venkatason, Nur Lisa Zaharan, Muhammad Dzafir Ismail, Wan Azman Wan Ahmad, Ahmad Syadi Mahmood Zuhdi
PURPOSE: Information is lacking on prescribing of preventative cardiovascular pharmacotherapies for patients with non-ST elevation myocardial infarction (NSTEMI) in the Asian region. This study examined the prescribing rate of these pharmacotherapies, comparing NSTEMI to STEMI, and variations across demographics and clinical factors within the NSTEMI group in the multi-ethnic Malaysian population. METHODS: This is a retrospective analysis of the Malaysian National Cardiovascular Disease Database-Acute Coronary Syndrome registry from year 2006 to 2013 (n = 30,873)...
March 26, 2018: European Journal of Clinical Pharmacology
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