Hermelijn H Smits, Pieter S Hiemstra, Clarissa Prazeres da Costa, Markus Ege, Michael Edwards, Holger Garn, Peter H Howarth, Tuomas Jartti, Esther C de Jong, Rick M Maizels, Ben J Marsland, Henry J McSorley, Anne Müller, Petra I Pfefferle, Huub Savelkoul, Jürgen Schwarze, Wendy W J Unger, Erika von Mutius, Maria Yazdanbakhsh, Christian Taube
The worldwide incidence and prevalence of asthma continues to increase. Asthma is now understood as an umbrella term for different phenotypes or endotypes, which arise through different pathophysiologic pathways. Understanding the many factors contributing to development of the disease is important for the identification of novel therapeutic targets for the treatment of certain asthma phenotypes. The hygiene hypothesis has been formulated to explain the increasing prevalence of allergic disease, including asthma...
March 2016: Journal of Allergy and Clinical Immunology