Anwar Abdurahman, Yu Li, Shi-Zheng Jia, Xin-Wen Xu, Shu-Jing Lin, Pei Ouyang, Zhi Jun He, Zhong-Hao Zhang, Qiong Liu, Ying Xu, Guo-Li Song
Selenoprotein K (SELENOK) is one of the endoplasmic reticulum(ER) protein that mainly functions in the regulation of endoplasmic reticulum stress (ERS), calcium flux, and antioxidant defense. Reactive oxygen species (ROS) is one of the key indicator of ferroptosis, and SELENOK inhibition could disrupt ROS balance, and consequently might cause ferroptosis. However, there are no previous studies about the mechanism of SELENOK in ferroptosis by regulating ROS. In this study, we report the effect of SELENOK inhibition on cell proliferation, viability, iron recycling-associated proteins, ROS, antioxidant enzymes, and lipid peroxidation of cervical cancer cells (HeLa cells)...
March 15, 2023: Metallomics: Integrated Biometal Science