keyword
https://read.qxmd.com/read/36921994/knockdown-of-the-selenok-gene-induces-ferroptosis-in-cervical-cancer-cells
#21
JOURNAL ARTICLE
Anwar Abdurahman, Yu Li, Shi-Zheng Jia, Xin-Wen Xu, Shu-Jing Lin, Pei Ouyang, Zhi Jun He, Zhong-Hao Zhang, Qiong Liu, Ying Xu, Guo-Li Song
Selenoprotein K (SELENOK) is one of the endoplasmic reticulum(ER) protein that mainly functions in the regulation of endoplasmic reticulum stress (ERS), calcium flux, and antioxidant defense. Reactive oxygen species (ROS) is one of the key indicator of ferroptosis, and SELENOK inhibition could disrupt ROS balance, and consequently might cause ferroptosis. However, there are no previous studies about the mechanism of SELENOK in ferroptosis by regulating ROS. In this study, we report the effect of SELENOK inhibition on cell proliferation, viability, iron recycling-associated proteins, ROS, antioxidant enzymes, and lipid peroxidation of cervical cancer cells (HeLa cells)...
March 15, 2023: Metallomics: Integrated Biometal Science
https://read.qxmd.com/read/36910985/real-time-monitoring-of-selenium-in-living-cells-by-fluorescence-resonance-energy-transfer-based-genetically-encoded-ratiometric-nanosensors
#22
JOURNAL ARTICLE
Reshma Bano, Mohd Mohsin, Mohammad Zeyaullah, Mohammad Suhail Khan
Selenium is a component of selenoproteins, which plays a crucial role in cellular redox homeostasis, thyroid metabolism, and DNA synthesis. Selenium has pleiotropic effects like antioxidant and anti-inflammatory activities; however, excess intake of selenium can imbalance such processes. The effects of selenium on human health are numerous and complex, demanding additional research to monitor the flux rate of selenium. Here, we have created a noninvasive and highly efficient genetically encoded fluorescence resonance energy transfer (FRET)-based nanosensor, SelFS ( Sel enium F RET- S ensor), for real-time monitoring of selenium at the cellular and subcellular levels...
March 7, 2023: ACS Omega
https://read.qxmd.com/read/36868433/selenium-deficiency-causes-hypertension-by-increasing-renal-at-1-receptor-expression-via-gpx1-h-2-o-2-nf-%C3%AE%C2%BAb-pathway
#23
JOURNAL ARTICLE
Lifu Lei, Fuwei Zhang, Juan Huang, Xiaoxin Zhou, Hongjia Yan, Caiyu Chen, Shuo Zheng, Liangyi Si, Pedro A Jose, Chunyu Zeng, Jian Yang
Epidemiological studies show an association between low body selenium and the risk of hypertension. However, whether selenium deficiency causes hypertension remains unknown. Here, we report that Sprague-Dawley rats fed a selenium-deficient diet for 16 weeks developed hypertension, accompanied with decreased sodium excretion. The hypertension of selenium-deficient rats was associated with increased renal angiotensin II type 1 receptor (AT1 R) expression and function that was reflected by the increase in sodium excretion after the intrarenal infusion of the AT1 R antagonist candesartan...
March 1, 2023: Free Radical Biology & Medicine
https://read.qxmd.com/read/36810819/selenium-alleviates-endoplasmic-reticulum-calcium-depletion-induced-endoplasmic-reticulum-stress-and-apoptosis-in-chicken-myocardium-after-mercuric-chloride-exposure
#24
JOURNAL ARTICLE
Pei-Chao Gao, An-Qi Wang, Xue-Wei Chen, Han Cui, Yue Li, Rui-Feng Fan
Mercury is a highly toxic heavy metal with definite cardiotoxic properties and can affect the health of humans and animals through diet. Selenium (Se) is a heart-healthy trace element and dietary Se has the potential to attenuate heavy metal-induced myocardial damage in humans and animals. This study was designed to explore antagonistic effect of Se on the cardiotoxicity of mercuric chloride (HgCl2 ) in chickens. Hyline brown hens received a normal diet, a diet containing 250 mg/L HgCl2 , or a diet containing 250 mg/L HgCl2 and 10 mg/kg Na2 SeO3 for 7 weeks, respectively...
February 22, 2023: Environmental Science and Pollution Research International
https://read.qxmd.com/read/36516721/loss-of-selenoprotein-w-in-murine-macrophages-alters-the-hierarchy-of-selenoprotein-expression-redox-tone-and-mitochondrial-functions-during-inflammation
#25
JOURNAL ARTICLE
Sougat Misra, Tai-Jung Lee, Aswathy Sebastian, John McGuigan, Chang Liao, Imhoi Koo, Andrew D Patterson, Randall M Rossi, Molly A Hall, Istvan Albert, K Sandeep Prabhu
Macrophages play a pivotal role in mediating inflammation and subsequent resolution of inflammation. The availability of selenium as a micronutrient and the subsequent biosynthesis of selenoproteins, containing the 21st amino acid selenocysteine (Sec), are important for the physiological functions of macrophages. Selenoproteins regulate the redox tone in macrophages during inflammation, the early onset of which involves oxidative burst of reactive oxygen and nitrogen species. SELENOW is a highly expressed selenoprotein in bone marrow-derived macrophages (BMDMs)...
December 8, 2022: Redox Biology
https://read.qxmd.com/read/36375805/roles-of-selenoprotein-k-in-oxidative-stress-and-endoplasmic-reticulum-stress-under-selenium-deficiency-in-chicken-liver
#26
JOURNAL ARTICLE
Wenyue Zhang, Xinyue Sun, Yutian Lei, Xiaojing Liu, Yilei Zhang, Yuqi Wang, Hongjin Lin
Selenoprotein K (SELENOK) is a major part of selenoprotein family. Selenoproteins have been proven playing vital roles in a variety of physiological processes. However, as a necessary supplement to the body of trace elements, how SELENOK regulates necroptosis in chicken liver has none clear claim. The purpose of this study was to cover the mechanism of SELENOK act in necroptosis of chicken liver. By feeding Se-deficiency diet for 1-day-old hyline chickens, we successfully built SELENOK-deficiency and discussed the regulation SELENOK have done...
November 11, 2022: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://read.qxmd.com/read/36362436/modulation-of-the-functional-state-of-mouse-neutrophils-by-selenium-nanoparticles-in-vivo
#27
JOURNAL ARTICLE
Valentina N Mal'tseva, Sergey V Gudkov, Egor A Turovsky
This study aimed to discover the immunomodulatory effect of selenium nanoparticles (SeNPs) on the functional state of neutrophils in vivo. Intraperitoneal injections of SeNPs (size 100 nm) 2.5 mg/kg/daily to BALB/c mice for a duration of 7-28 days led to the development of an inflammatory reaction, which was registered by a significant increase in the number of neutrophils released from the peritoneal cavity, as well as their activated state, without additional effects. At the same time, subcutaneous injections of the same SeNPs preparations at concentrations of 0...
November 7, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36358931/metabolism-of-selenium-selenocysteine-and-selenoproteins-in-ferroptosis-in-solid-tumor-cancers
#28
REVIEW
Briana K Shimada, Sydonie Swanson, Pamela Toh, Lucia A Seale
A potential target of precision nutrition in cancer therapeutics is the micronutrient selenium (Se). Se is metabolized and incorporated as the amino acid selenocysteine (Sec) into 25 human selenoproteins, including glutathione peroxidases (GPXs) and thioredoxin reductases (TXNRDs), among others. Both the processes of Se and Sec metabolism for the production of selenoproteins and the action of selenoproteins are utilized by cancer cells from solid tumors as a protective mechanism against oxidative damage and to resist ferroptosis, an iron-dependent cell death mechanism...
October 28, 2022: Biomolecules
https://read.qxmd.com/read/36336122/the-role-of-selenoproteins-in-neutrophils-during-inflammation
#29
JOURNAL ARTICLE
Tai-Jung Lee, Shaneice K Nettleford, Allison McGlynn, Bradley A Carlson, Girish S Kirimanjeswara, K Sandeep Prabhu
Polymorphonuclear neutrophils (PMNs)-derived ROS are involved in the regulation of multiple functions of PMNs critical in both inflammation and its timely resolution. Selenium is an essential trace element that functions as a gatekeeper of cellular redox homeostasis in the form of selenoproteins. Despite their well-studied involvement in regulating functions of various immune cells, limited studies have focused on the regulation of selenoproteins in PMN and their associated functions. Ex-vivo treatment of murine primary bone marrow derived PMNs with bacterial endotoxin lipopolysaccharide (LPS) indicated temporal regulation of several selenoprotein genes at the mRNA level...
November 3, 2022: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/36291795/mitf-is-regulated-by-redox-signals-controlled-by-the-selenoprotein-thioredoxin-reductase-1
#30
JOURNAL ARTICLE
Chelsey D Kline, Madeleine Anderson, John W Bassett, Gail Kent, Rachel Berryman, Matthew Honeggar, Shosuke Ito, Kazumasa Wakamatsu, Arup K Indra, Philip J Moos, Sancy A Leachman, Pamela B Cassidy
TR1 and other selenoproteins have paradoxical effects in melanocytes and melanomas. Increasing selenoprotein activity with supplemental selenium in a mouse model of UV-induced melanoma prevents oxidative damage to melanocytes and delays melanoma tumor formation. However, TR1 itself is positively associated with progression in human melanomas and facilitates metastasis in melanoma xenografts. Here, we report that melanocytes expressing a microRNA directed against TR1 (TR1low ) grow more slowly than control cell lines and contain significantly less melanin...
October 13, 2022: Cancers
https://read.qxmd.com/read/36265651/selenium-and-selenoproteins-in-thermogenic-adipocytes
#31
JOURNAL ARTICLE
Briana K Shimada, Ligia M Watanabe, Sydonie Swanson, Pamela Toh, Lucia A Seale
Selenium (Se) is involved in energy metabolism in the liver, white adipose tissue, and skeletal muscle, and may also play a role in thermogenic adipocytes, i.e. brown and beige adipocytes. Thereby this micronutrient is a key nutritional target to aid in combating obesity and metabolic diseases. In thermogenic adipocytes, particularly in brown adipose tissue (BAT), the selenoprotein type 2 iodothyronine deiodinase (DIO2) is essential for the activation of adaptive thermogenesis. Recent evidence has suggested that additional selenoproteins may also be participating in this process, and a role for Se itself through its metabolic pathways is also envisioned...
October 18, 2022: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/36252341/selenoprotein-k-contributes-to-cd36-subcellular-trafficking-in-hepatocytes-by-accelerating-nascent-copii-vesicle-formation-and-aggravates-hepatic-steatosis
#32
JOURNAL ARTICLE
Mengyue You, Fan Wu, Meilin Gao, Mengyue Chen, Shu Zeng, Yang Zhang, Wei Zhao, Danyang Li, Li Wei, Xiong Z Ruan, Yaxi Chen
SelenoproteinK (SelK), an endoplasmic reticulum (ER) - resident protein, possesses the property of mediate oxidation resistance and ER - associated protein degradation (ERAD) in several tissues. Here, we found that increased SelK markedly promotes fatty acid translocase (CD36) subcellular trafficking and aggravates lipid accumulation in hepatocytes. We demonstrated that SelK is required for the assembly of COPII vesicles and accelerates transport of palmitoylated-CD36 from the ER to Golgi, thus facilitating CD36 plasma membrane distribution both in vivo and in vitro...
October 7, 2022: Redox Biology
https://read.qxmd.com/read/36182809/seizures-ataxia-and-parvalbumin-expressing-interneurons-respond-to-selenium-supply-in-selenop-deficient-mice
#33
JOURNAL ARTICLE
Ulrich Schweizer, Eva K Wirth, Thomas Klopstock, Sabine M Hölter, Lore Becker, Jackob Moskovitz, Tilman Grune, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Josef Köhrle, Lutz Schomburg
Mice with constitutive disruption of the Selenop gene have been key to delineate the importance of selenoproteins in neurobiology. However, the phenotype of this mouse model is exquisitely dependent on selenium supply and timing of selenium supplementation. Combining biochemical, histological, and behavioral methods, we tested the hypothesis that parvalbumin-expressing interneurons in the primary somatosensory cortex and hippocampus depend on dietary selenium availability in Selenop-/- mice. Selenop-deficient mice kept on adequate selenium diet (0...
September 24, 2022: Redox Biology
https://read.qxmd.com/read/35956267/selenium-status-and-supplementation-effects-in-pregnancy-a-study-on-mother-child-pairs-from-a-single-center-cohort
#34
JOURNAL ARTICLE
Dorota Filipowicz, Ewelina Szczepanek-Parulska, Małgorzata Kłobus, Krzysztof Szymanowski, Thilo Samson Chillon, Sabrina Asaad, Qian Sun, Aniceta A Mikulska-Sauermann, Marta Karaźniewicz-Łada, Franciszek K Główka, Dominika Wietrzyk, Lutz Schomburg, Marek Ruchała
The demand for selenium (Se) increases during pregnancy since this element supports child growth, proper neuronal development and maternal thyroid function. The issue is particularly relevant for populations living in areas with a limited selenium supply, where many pregnant women opt for Se supplementation. The efficiency of this measure is unknown, although it seems vital in the prevention of severe Se deficiency. In order to evaluate this hypothesis, an observational study was conducted in Poland, where Se deficiency is prevalent...
July 27, 2022: Nutrients
https://read.qxmd.com/read/35917681/emerging-roles-of-er-resident-selenoproteins-in-brain-physiology-and-physiopathology
#35
REVIEW
Cédric Jehan, Dorthe Cartier, Christine Bucharles, Youssef Anouar, Isabelle Lihrmann
The brain has a very high oxygen consumption rate and is particularly sensitive to oxidative stress. It is also the last organ to suffer from a loss of selenium (Se) in case of deficiency. Se is a crucial trace element present in the form of selenocysteine, the 21st proteinogenic amino acid present in selenoproteins, an essential protein family in the brain that participates in redox signaling. Among the most abundant selenoproteins in the brain are glutathione peroxidase 4 (GPX4), which reduces lipid peroxides and prevents ferroptosis, and selenoproteins W, I, F, K, M, O and T...
July 19, 2022: Redox Biology
https://read.qxmd.com/read/35883755/selenoprotein-k-is-essential-for-the-migration-and-phagocytosis-of-immature-dendritic-cells
#36
JOURNAL ARTICLE
Huan Xia, Yongmei Wang, Jie Dai, Xin Zhang, Jun Zhou, Zhu Zeng, Yi Jia
Selenoprotein K (SELENOK) is an endoplasmic reticulum stress (ERS)-regulated protein required for the calcium (Ca2+ ) flux-mediated migration of T cells and neutrophils, and the migration and phagocytosis of macrophages and microglia. However, the effect of SELENOK on the regulation of the immune function of dendritic cells (DCs), including immature DCs (imDCs) and mature DCs (mDCs), is still unclear. In this study, imDCs prepared from SELENOK knockout mice were used to evaluate the effect of SELENOK on the migration and phagocytosis of imDCs...
June 27, 2022: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/35846991/prominent-effects-of-berbamine-hydrochloride-on-alzheimer-s-disease-model-mice
#37
JOURNAL ARTICLE
Chang-Lan Chen, Hai-Li Wang, Feng Qian, Mei-Hua Liu, Xiao-Xuan Guo, Jing Lv, Jia-Hui Huang, Nai-Zhi Zhang, Zheng Xiang
Very few anti-Alzheimer's disease (AD) drugs are clinically available at present due to the complex mechanism of Alzheimer's disease. For the purpose of discovering potential anti-AD drugs in bisbenzylisoquinoline alkaloids, the anti-AD function and the mechanism of the function of berbamine hydrochloride (BBMH) were studied. Three kinds of AD model mice, double transgenic APP/PS1 AD mice, Gal-Alu AD mice induced by the intraperitoneal injection of d-galactose combined with the intragastric administration of aluminum trichloride, and Alu AD-like mice induced by stereotactic brain injection of aluminum trichloride, were administered with BBMH for 40 days at a dosage of 280 mg/kg/d...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35841984/the-decrease-of-selenoprotein-k-induced-by-selenium-deficiency-in-diet-improves-apoptosis-and-cell-progression-block-in-chicken-liver-via-the-pten-pi3k-akt-pathway
#38
JOURNAL ARTICLE
Wenyue Zhang, Kai Yin, Jiahui Shi, Xu Shi, Xue Qi, Hongjin Lin
Selenoprotein K (SELK) is imperative for normal development of chicken. It does regulate to chicken's physiological function. However, the injury of SELK-deficiency done on chicken liver and its underlying mechanism involved has not yet been covered. As papers said, foreign supplement can change the situation of hepatic health [1,2]. Therefore, we built SELK- deficiency model by feeding diet which contained low concentration of selenium (Se) to discuss SELK's regulation mechanism. Through using TUNEL, TEM, western blot and qRT-PCR we found apoptosis occurred in chicken liver in the SELK-deficiency groups...
July 13, 2022: Free Radical Biology & Medicine
https://read.qxmd.com/read/35698232/identification-of-er-sr-resident-proteins-as-biomarkers-for-er-sr-calcium-depletion-in-skeletal-muscle-cells
#39
JOURNAL ARTICLE
Lacey K Greer, Katherine G Meilleur, Brandon K Harvey, Emily S Wires
BACKGROUND: Aberrations to endoplasmic/sarcoplasmic reticulum (ER/SR) calcium concentration can result in the departure of endogenous proteins in a phenomenon termed exodosis. Redistribution of the ER/SR proteome can have deleterious effects to cell function and cell viability, often contributing to disease pathogenesis. Many proteins prone to exodosis reside in the ER/SR via an ER retention/retrieval sequence (ERS) and are involved in protein folding, protein modification, and protein trafficking...
June 13, 2022: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/35637349/ribosome-stalling-during-selenoprotein-translation-exposes-a-ferroptosis-vulnerability
#40
JOURNAL ARTICLE
Zhipeng Li, Lucas Ferguson, Kirandeep K Deol, Melissa A Roberts, Leslie Magtanong, Joseph M Hendricks, Gergey Alzaem Mousa, Seda Kilinc, Kaitlin Schaefer, James A Wells, Michael C Bassik, Andrei Goga, Scott J Dixon, Nicholas T Ingolia, James A Olzmann
The selenoprotein glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid peroxides into nontoxic lipid alcohols. GPX4 has emerged as a promising therapeutic target for cancer treatment, but some cancer cells are resistant to ferroptosis triggered by GPX4 inhibition. Using a chemical-genetic screen, we identify LRP8 (also known as ApoER2) as a ferroptosis resistance factor that is upregulated in cancer. Loss of LRP8 decreases cellular selenium levels and the expression of a subset of selenoproteins...
May 30, 2022: Nature Chemical Biology
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