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selenoprotein K

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https://www.readbyqxmd.com/read/27923410/supplementation-with-brazil-nuts-and-green-tea-extract-regulates-targeted-biomarkers-related-to-colorectal-cancer-risk-in-humans
#1
Ying Hu, Graeme H McIntosh, Richard K Le Leu, Roshini Somashekar, Xing Q Meng, Geetha Gopalsamy, Libby Bambaca, Ross A McKinnon, Graeme P Young
Se and green tea have been shown in epidemiological, observational and preclinical studies to be inversely related to the risk of developing colorectal cancer (CRC). However, there are limited studies to evaluate their regulatory effects on genes/proteins that relate to CRC oncogenesis in human subjects, such as selenoproteins, WNT signalling pathway, inflammation and methylation. This study examined the effects of supplementation of Se using Brazil nuts and green tea extract (GTE) capsules, alone and in combination, on targeted biomarkers...
December 7, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27832637/acute-overfeeding-does-not-alter-liver-or-adipose-tissue-derived-cytokines-in-healthy-humans
#2
Miaoxin Chen, Bo Liu, Campbell H Thompson, Gary A Wittert, Leonie K Heilbronn
BACKGROUND/AIMS: The secretions of liver-derived cytokines angiopoietin-like 6, insulin-like growth factor 1, selenoprotein-P and C-reactive protein and adipokines, adiponectin and monocyte chemoattractant protein-1 are altered in obese individuals, and they directly induce insulin resistance in both cellular and animal models. This study is aimed at examining the effects of acute overnutrition on these cytokines in healthy individuals, and identifying association with markers of insulin resistance...
November 11, 2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27752918/minimum-selenium-requirements-increase-when-repleting-second-generation-selenium-deficient-rats-but-are-not-further-altered-by-vitamin-e-deficiency
#3
Roger A Sunde, Kevin M Thompson, Kevin L Fritsche, Jacqueline K Evenson
Second-generation selenium-deficient weanling rats fed graded levels of dietary Se were used (a) to study the impact of initial Se deficiency on dietary Se requirements; (b) to determine if further decreases in selenoperoxidase expression, especially glutathione peroxidase 4 (Gpx4), affect growth or gross disease; and (c) to examine the impact of vitamin E deficiency on biochemical and molecular biomarkers of Se status. Rats were fed a vitamin E-deficient and Se-deficient crystalline amino acid diet (3 ng Se/g diet) or that diet supplemented with 100 μg/g all-rac-α-tocopheryl acetate and/or 0, 0...
October 17, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27645994/selenoprotein-gene-nomenclature
#4
Vadim N Gladyshev, Elias S Arnér, Marla J Berry, Regina Brigelius-Flohé, Elspeth A Bruford, Raymond F Burk, Bradley A Carlson, Sergi Castellano, Laurent Chavatte, Marcus Conrad, Paul R Copeland, Alan M Diamond, Donna M Driscoll, Ana Ferreiro, Leopold Flohé, Fiona R Green, Roderic Guigó, Diane E Handy, Dolph L Hatfield, John Hesketh, Peter R Hoffmann, Arne Holmgren, Robert J Hondal, Michael T Howard, Kaixun Huang, Hwa-Young Kim, Ick Young Kim, Josef Köhrle, Alain Krol, Gregory V Kryukov, Byeong Jae Lee, Byung Cheon Lee, Xin Gen Lei, Qiong Liu, Alain Lescure, Alexei V Lobanov, Joseph Loscalzo, Matilde Maiorino, Marco Mariotti, K Sandeep Prabhu, Margaret P Rayman, Sharon Rozovsky, Gustavo Salinas, Edward E Schmidt, Lutz Schomburg, Ulrich Schweizer, Miljan Simonović, Roger A Sunde, Petra A Tsuji, Susan Tweedie, Fulvio Ursini, Philip D Whanger, Yan Zhang
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2)...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27601625/selenoprotein-k-regulation-of-palmitoylation-and-calpain-cleavage-of-asap2-is-required-for-efficient-fc%C3%AE-r-mediated-phagocytosis
#5
Robert L Norton, Gregory J Fredericks, Zhi Huang, Jeffrey D Fay, FuKun W Hoffmann, Peter R Hoffmann
Effective activation of macrophages through phagocytic Fcγ receptors (FcγR) has been shown to require selenoprotein K (Selk). We set out to determine whether the FcγR-mediated uptake process itself also requires Selk and potential underlying mechanisms. Macrophages from Selk knockout (KO) mice were less efficient compared with wild-type (WT) controls in engulfing IgG-coated fluorescent beads. Using LC-MS/MS to screen for Selk-binding partners involved in FcγR-mediated phagocytosis, we identified Arf-GAP with SH3 domain, ANK repeat, and PH domain-containing protein 2 (ASAP2)...
September 6, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27588899/selenoprotein-h-is-an-essential-regulator-of-redox-homeostasis-that-cooperates-with-p53-in-development-and-tumorigenesis
#6
Andrew G Cox, Allison Tsomides, Andrew J Kim, Diane Saunders, Katie L Hwang, Kimberley J Evason, Jerry Heidel, Kristin K Brown, Min Yuan, Evan C Lien, Byung Cheon Lee, Sahar Nissim, Bryan Dickinson, Sagar Chhangawala, Christopher J Chang, John M Asara, Yariv Houvras, Vadim N Gladyshev, Wolfram Goessling
Selenium, an essential micronutrient known for its cancer prevention properties, is incorporated into a class of selenocysteine-containing proteins (selenoproteins). Selenoprotein H (SepH) is a recently identified nucleolar oxidoreductase whose function is not well understood. Here we report that seph is an essential gene regulating organ development in zebrafish. Metabolite profiling by targeted LC-MS/MS demonstrated that SepH deficiency impairs redox balance by reducing the levels of ascorbate and methionine, while increasing methionine sulfoxide...
September 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27524654/selenoprotein-p-is-elevated-in-individuals-with-obesity-but-is-not-independently-associated-with-insulin-resistance
#7
Miaoxin Chen, Bo Liu, David Wilkinson, Amy T Hutchison, Campbell H Thompson, Gary A Wittert, Leonie K Heilbronn
Selenoprotein P (SeP) is secreted primarily by the liver and postulated to cause insulin resistance. The aim of this study was to measure plasma SeP in individuals who are lean (N=29) or overweight/obese (N=34), and examine relationships between circulating SeP, SEPP1 (SeP, plasma 1) expression in subcutaneous adipose tissue, and markers of insulin resistance. SeP was higher in individuals who were overweight/obese (P<0.001), and associated with insulin resistance by HOMA-IR and by clamp, but not independently of BMI...
August 11, 2016: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27344320/gene-expression-of-selenoproteins-can-be-regulated-by-selenoprotein-k-silencing-in-chicken-myoblasts
#8
Ruifeng Fan, Haidong Yao, Xia Zhao, Changyu Cao, Tianshu Yang, Yilin Luan, Ziwei Zhang, Shiwen Xu
The aim of the present study was to clarify the effect of Selenoprotein K (Selk) silencing on the mRNA expression of 25 selenoproteins in chicken myoblasts. The specific small interfering RNA (siRNA) for Selk gene was designed and transfected into chicken myoblasts. Post-transfection mRNA expression of 25 selenoproteins was determined at various time periods i.e., 24, 48 and 72 h. Moreover, based on the results of expression of 25 selenoproteins, correlation analysis and principal component analysis (PCA) were used for further analysis...
August 2016: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/27275761/human-mir-544a-modulates-selk-expression-in-hepatocarcinoma-cell-lines
#9
Nicoletta Potenza, Filomena Castiello, Marta Panella, Giovanni Colonna, Gennaro Ciliberto, Aniello Russo, Susan Costantini
Hepatocellular carcinoma (HCC) is a multi-factorial cancer with a very poor prognosis; therefore, there are several investigations aimed at the comprehension of the molecular mechanisms leading to development and progression of HCC and at the definition of new therapeutic strategies. We have recently evaluated the expression of selenoproteins in HCC cell lines in comparison with normal hepatocytes. Recent results have shown that some of them are down- and others up-regulated, including the selenoprotein K (SELK), whose expression was also induced by sodium selenite treatment on cells...
2016: PloS One
https://www.readbyqxmd.com/read/27103578/transcriptomics-and-proteomics-show-that-selenium-affects-inflammation-cytoskeleton-and-cancer-pathways-in-human-rectal-biopsies
#10
Catherine Méplan, Ian T Johnson, Abigael C J Polley, Simon Cockell, David M Bradburn, Daniel M Commane, Ramesh P Arasaradnam, Francis Mulholland, Anze Zupanic, John C Mathers, John Hesketh
Epidemiologic studies highlight the potential role of dietary selenium (Se) in colorectal cancer prevention. Our goal was to elucidate whether expression of factors crucial for colorectal homoeostasis is affected by physiologic differences in Se status. Using transcriptomics and proteomics followed by pathway analysis, we identified pathways affected by Se status in rectal biopsies from 22 healthy adults, including 11 controls with optimal status (mean plasma Se = 1.43 μM) and 11 subjects with suboptimal status (mean plasma Se = 0...
August 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/26714931/biological-activity-of-selenium-revisited
#11
REVIEW
Jagoda K Wrobel, Ronan Power, Michal Toborek
Selenium (Se) is an essential micronutrient that exerts multiple and complex effects on human health. Se is essential for human well-being largely due to its potent antioxidant, anti-inflammatory, and antiviral properties. The physiological functions of Se are carried out by selenoproteins, in which Se is specifically incorporated as the amino acid, selenocysteine. Importantly, both beneficial and toxic effects of Se have been reported suggesting that the mode of action of Se is strictly chemical form and concentration dependent...
February 2016: IUBMB Life
https://www.readbyqxmd.com/read/26658762/dna-damage-and-oxidative-stress-response-to-selenium-yeast-in-the-non-smoking-individuals-a-short-term-supplementation-trial-with-respect-to-gpx1-and-sepp1-polymorphism
#12
E Jablonska, S Raimondi, J Gromadzinska, E Reszka, E Wieczorek, M B Krol, A Smok-Pieniazek, M Nocun, M Stepnik, K Socha, M H Borawska, W Wasowicz
PURPOSE: Selenium, both essential and toxic element, is considered to protect against cancer, though human supplementation trials have generated many inconsistent data. Genetic background may partially explain a great variability of the studies related to selenium and human health. The aim of this study was to assess whether functional polymorphisms within two selenoprotein-encoding genes modify the response to selenium at the level of oxidative stress, DNA damage, and mRNA expression, especially in the individuals with a relatively low selenium status...
December 10, 2015: European Journal of Nutrition
https://www.readbyqxmd.com/read/26644468/selenoprotein-expression-in-macrophages-is-critical-for-optimal-clearance-of-parasitic-helminth-nippostrongylus-brasiliensis
#13
Shakira M Nelson, Ashley E Shay, Jamaal L James, Bradley A Carlson, Joseph F Urban, K Sandeep Prabhu
The plasticity of macrophages is evident in helminthic parasite infections, providing protection from inflammation. Previously we demonstrated that the micronutrient selenium induces a phenotypic switch in macrophage activation from a classically activated (pro-inflammatory; M1/CAM) toward an alternatively activated (anti-inflammatory; M2/AAM) phenotype, where cyclooxygenase (COX)-dependent cyclopentenone prostaglandin J2 (15d-PGJ2) plays a key role. Here, we hypothesize that dietary selenium modulates macrophage polarization toward an AAM phenotype to assist in the increasing clearance of adult Nippostrongylus brasiliensis, a gastrointestinal nematode parasite...
February 5, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26627243/genome-of-rhodnius-prolixus-an-insect-vector-of-chagas-disease-reveals-unique-adaptations-to-hematophagy-and-parasite-infection
#14
Rafael D Mesquita, Raquel J Vionette-Amaral, Carl Lowenberger, Rolando Rivera-Pomar, Fernando A Monteiro, Patrick Minx, John Spieth, A Bernardo Carvalho, Francisco Panzera, Daniel Lawson, André Q Torres, Jose M C Ribeiro, Marcos H F Sorgine, Robert M Waterhouse, Michael J Montague, Fernando Abad-Franch, Michele Alves-Bezerra, Laurence R Amaral, Helena M Araujo, Ricardo N Araujo, L Aravind, Georgia C Atella, Patricia Azambuja, Mateus Berni, Paula R Bittencourt-Cunha, Gloria R C Braz, Gustavo Calderón-Fernández, Claudia M A Carareto, Mikkel B Christensen, Igor R Costa, Samara G Costa, Marilvia Dansa, Carlos R O Daumas-Filho, Iron F De-Paula, Felipe A Dias, George Dimopoulos, Scott J Emrich, Natalia Esponda-Behrens, Patricia Fampa, Rita D Fernandez-Medina, Rodrigo N da Fonseca, Marcio Fontenele, Catrina Fronick, Lucinda A Fulton, Ana Caroline Gandara, Eloi S Garcia, Fernando A Genta, Gloria I Giraldo-Calderón, Bruno Gomes, Katia C Gondim, Adriana Granzotto, Alessandra A Guarneri, Roderic Guigó, Myriam Harry, Daniel S T Hughes, Willy Jablonka, Emmanuelle Jacquin-Joly, M Patricia Juárez, Leonardo B Koerich, Angela B Lange, José Manuel Latorre-Estivalis, Andrés Lavore, Gena G Lawrence, Cristiano Lazoski, Claudio R Lazzari, Raphael R Lopes, Marcelo G Lorenzo, Magda D Lugon, David Majerowicz, Paula L Marcet, Marco Mariotti, Hatisaburo Masuda, Karine Megy, Ana C A Melo, Fanis Missirlis, Theo Mota, Fernando G Noriega, Marcela Nouzova, Rodrigo D Nunes, Raquel L L Oliveira, Gilbert Oliveira-Silveira, Sheila Ons, Ian Orchard, Lucia Pagola, Gabriela O Paiva-Silva, Agustina Pascual, Marcio G Pavan, Nicolás Pedrini, Alexandre A Peixoto, Marcos H Pereira, Andrew Pike, Carla Polycarpo, Francisco Prosdocimi, Rodrigo Ribeiro-Rodrigues, Hugh M Robertson, Ana Paula Salerno, Didier Salmon, Didac Santesmasses, Renata Schama, Eloy S Seabra-Junior, Livia Silva-Cardoso, Mario A C Silva-Neto, Matheus Souza-Gomes, Marcos Sterkel, Mabel L Taracena, Marta Tojo, Zhijian Jake Tu, Jose M C Tubio, Raul Ursic-Bedoya, Thiago M Venancio, Ana Beatriz Walter-Nuno, Derek Wilson, Wesley C Warren, Richard K Wilson, Erwin Huebner, Ellen M Dotson, Pedro L Oliveira
Rhodnius prolixus not only has served as a model organism for the study of insect physiology, but also is a major vector of Chagas disease, an illness that affects approximately seven million people worldwide. We sequenced the genome of R. prolixus, generated assembled sequences covering 95% of the genome (∼ 702 Mb), including 15,456 putative protein-coding genes, and completed comprehensive genomic analyses of this obligate blood-feeding insect. Although immune-deficiency (IMD)-mediated immune responses were observed, R...
December 1, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26601078/high-t3-low-t4-serum-levels-in-mct8-deficiency-are-not-caused-by-increased-hepatic-conversion-through-type-i-deiodinase
#15
Eva K Wirth, Eddy Rijntjes, Franziska Meyer, Josef Köhrle, Ulrich Schweizer
BACKGROUND: The Allan-Herndon-Dudley syndrome is a severe psychomotor retardation accompanied by specific changes in circulating thyroid hormone levels (high T3, low T4). These are caused by mutations in the thyroid hormone transmembrane transport protein monocarboxylate transporter 8 (MCT8). OBJECTIVE: To test the hypothesis that circulating low T4 and high T3 levels are caused by enhanced conversion of T4 via increased activity of hepatic type I deiodinase (Dio1)...
September 2015: European Thyroid Journal
https://www.readbyqxmd.com/read/26504085/selenoprotein-s-dependent-selenoprotein-k-binding-to-p97-vcp-protein-is-essential-for-endoplasmic-reticulum-associated-degradation
#16
Jea Hwang Lee, Ki Jun Park, Jun Ki Jang, Yeong Ha Jeon, Kwan Young Ko, Joon Hyun Kwon, Seung-Rock Lee, Ick Young Kim
Cytosolic valosin-containing protein (p97(VCP)) is translocated to the ER membrane by binding to selenoprotein S (SelS), which is an ER membrane protein, during endoplasmic reticulum-associated degradation (ERAD). Selenoprotein K (SelK) is another known p97(VCP)-binding selenoprotein, and the expression of both SelS and SelK is increased under ER stress. To understand the regulatory mechanisms of SelS, SelK, and p97(VCP) during ERAD, the interaction of the selenoproteins with p97(VCP) was investigated using N2a cells and HEK293 cells...
December 11, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26468123/selenium-deficiency-occurs-in-some-patients-with-moderate-to-severe-cirrhosis-and-can-be-corrected-by-administration-of-selenate-but-not-selenomethionine-a-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Raymond F Burk, Kristina E Hill, Amy K Motley, Daniel W Byrne, Brooke K Norsworthy
BACKGROUND: Selenomethionine, which is the principal dietary form of selenium, is metabolized by the liver to selenide, which is the form of the element required for the synthesis of selenoproteins. The liver synthesizes selenium-rich selenoprotein P (SEPP1) and secretes it into the plasma to supply extrahepatic tissues with selenium. OBJECTIVES: We conducted a randomized controlled trial to determine whether cirrhosis is associated with functional selenium deficiency (the lack of selenium for the process of selenoprotein synthesis even though selenium intake is not limited) and, if it is, whether the deficiency is associated with impairment of selenomethionine metabolism...
November 2015: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26406357/the-evolving-versatility-of-selenium-in-biology
#18
EDITORIAL
Regina Brigelius-Flohé
This editorial shortly summarizes the highlights described in the Forum, novelties about selenoproteins. Two articles describe the selenoprotein biosynthesis and the role of so far identified proteins involved, including that of selenocysteine-β-lyase, which also may link selenoproteins to energy metabolism. Novel and, in part, unexpected functions are reviewed. Thioredoxin reductase 1 (TrxR1) can change from an anti- to a pro-oxidant and appears to be involved in the regulation of the Nrf2/Keap1 system. Methionine sulfoxide reductase B1 (MsrB1) catalyzes a novel posttranslational protein modification...
October 1, 2015: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/26399395/gene-specific-regulation-of-hepatic-selenoprotein-expression-by-interleukin-6
#19
J Martitz, N-P Becker, K Renko, M Stoedter, S Hybsier, L Schomburg
Sepsis is a severe inflammatory disease resulting in excessive production of pro-inflammatory cytokines including interleukin-6 (IL-6), causing oxidative stress, tissue damage and organ dysfunction. Health benefits have been observed upon selenium (Se) supplementation in severe sepsis. Selenium is incorporated into selenoproteins implicated in anti-oxidative defence, thyroid hormone metabolism and immunoregulation. Selenium metabolism is controlled by hepatocytes synthesizing and secreting the Se transporter selenoprotein P (SePP)...
November 2015: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/26273132/dietary-selenium-regulation-of-glutathione-peroxidase-mrna-and-other-selenium-dependent-parameters-in-male-rats
#20
Sherri L Weiss, Jacqueline K Evenson, Kevin M Thompson, Roger A Sunde
Weanling male rats were fed a basal torula yeast diet (0.007 μg Se/g diet) supplemented with graded levels of Se (0 to 0.2 μg Se/g diet as Na2SeO3) (three rats/group) to evaluate classical glutathione peroxidase (GPX1, GSH:H2O2, oxidoreductase, EC 1.11.1.9) mRNA level as an indicator of intracellular Se status. Growth was followed throughout the dietary treatment and a number of Se-dependent parameters including liver GPX1 mRNA levels were determined after 33 days. Growth was not impaired at any level of dietary Se supplementation...
February 1997: Journal of Nutritional Biochemistry
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