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https://www.readbyqxmd.com/read/29909605/anemia-in-conventional-hemodialysis-finding-the-optimal-treatment-balance
#1
Takeshi Hasegawa, Fumihiko Koiwa, Tadao Akizawa
Renal anemia is a serious and common complication in hemodialysis (HD) patients. The introduction of erythropoiesis-stimulating agents (ESAs) has dramatically improved hemoglobin levels and outcomes. Several interventional studies reported that excessive correction of anemia and the massive use of ESA can trigger cardiovascular disease (CVD), and consequently may worsen the prognosis of patients undergoing HD. Therefore, it has been widely recognized that large doses of ESA should be used with caution. An effective use of iron preparations is required to yield the optimal effect of ESA...
June 17, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29909570/functions-and-impact-of-tal-like-genes-in-animals-with-regard-to-applied-aspects
#2
REVIEW
Min Zhu, Xiaolong Hu, Guangli Cao, Renyu Xue, Chengliang Gong
A large number of DNAs in eukaryote genomes can code for atypical transcripts, and their functions are controversial. It has been reported that the transcripts contain many small open reading frames (sORFs), which were originally considered as non-translatable RNAs. However, increasing evidence has suggested that some of these sORFs can encode for small peptides and some are conserved across large evolutionary distances. It has been reported that the small peptides have functions and may be involved in varieties of cellular processes, playing important roles in development, physiology, and metabolism...
June 16, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29909553/increasing-quality-of-life-in-pulmonary-arterial-hypertension-is-there-a-role-for-nutrition
#3
REVIEW
Paulien Vinke, Suzanne M Jansen, Renger F Witkamp, Klaske van Norren
Pulmonary arterial hypertension (PAH) is a progressive disease primarily affecting the pulmonary vasculature and heart. PAH patients suffer from exercise intolerance and fatigue, negatively affecting their quality of life. This review summarizes current insights in the pathophysiological mechanisms underlying PAH. It zooms in on the potential involvement of nutritional status and micronutrient deficiencies on PAH exercise intolerance and fatigue, also summarizing the potential benefits of exercise and nutritional interventions...
June 16, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29909502/increased-ngal-level-associated-with-iron-store-in-chronic-kidney-disease-with-anemia
#4
Daijun Xiang, Xiuying Wang, Peipei Liu, Yuling Pan, Qian Zhang, Xiuping Chi, Ying Jing, Xinxin Duan, Qiaozhen Wei, Jianan Wang, Mianyang Li, Chengbin Wang
An iron scarcity often occurs in chronic kidney disease (CKD). Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of acute kidney injury, is associated with iron metabolism. The present study determined the association between serum NGAL and iron status in chronic kidney disease with anemia. A total of 154 adult CKD patients were divided into anemia and without anemia groups. The anemia groups were further subdivided into two groups based on the presence or absence of iron deficiency, defined as a transferrin saturation (TSAT) < 20%...
June 16, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29909475/stress-genes-and-hypertension-contribution-of-the-isiah-rat-strain-study
#5
REVIEW
Olga E Redina, Arcady L Markel
PURPOSE OF REVIEW: Acute psychoemotional stress is one of the causes of a sharp increase in blood pressure. However, the question if the stress may promote the hypertensive disease development is still open. This review aims, firstly, to show that the genetically determined enhanced responsiveness to stress is linked to sustained hypertension development and, secondly, to characterize the main physiological mechanisms and genetic factors implicated in the pathogenesis of stress-sensitive hypertension...
June 16, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29909440/thrombospondin-1-interactions-regulate-eicosanoid-metabolism-and-signaling-in-cancer-related-inflammation
#6
Manuel U Ramirez, Elizabeth R Stirling, Nancy J Emenaker, David D Roberts, David R Soto-Pantoja
The metabolism of arachidonic acid and other polyunsaturated fatty acids produces eicosanoids, a family of biologically active lipids that are implicated in homeostasis and in several pathologies that involve inflammation. Inflammatory processes mediated by eicosanoids promote carcinogenesis by exerting direct effects on cancer cells and by affecting the tumor microenvironment. Therefore, understanding how eicosanoids mediate cancer progression may lead to better approaches and chemopreventive strategies for the treatment of cancer...
June 16, 2018: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/29909417/metabolic-syndrome-and-the-iodine-dose-creatinine-clearance-ratio-as-determinants-of-contrast-induced-acute-kidney-injury
#7
Ali Amiri, Reza Ghanavati, Hassan Riahi Beni, Seyyed Hashem Sezavar, Mehrdad Sheykhvatan, Mahsa Arab
BACKGROUND: Finding patients at risk of developing contrast-induced acute kidney injury (CI-AKI) is important because of its associated complications. In the present study, the contribution of different variables, such as the presence of metabolic syndrome (MetS), the volume creatinine clearance (V/CrCl) ratio, the iodine-dose (I-dose)/CrCl ratio, or hypertension, to CI-AKI was evaluated. METHODS: A total of 255 patients undergoing elective coronary angiography with or without intervention were enrolled and divided into a MetS and a control group...
June 15, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29909411/hiv-and-aging-perhaps-not-as-dramatic-as-we-feared
#8
Tanja Engel, Marieke Raffenberg, Catia Marzolini, Matthias Cavassini, Helen Kovari, Barbara Hasse, Philip E Tarr
Ever since the introduction of highly active antiretroviral therapy (ART) in 1995, HIV infection has been linked to "metabolic" complications (insulin resistance, dyslipidemia, osteoporosis, and others). Studies suggested increased rates of myocardial infarction, renal insufficiency, neurocognitive dysfunction, and fractures in HIV-postitive patients. Even long-term suppression of HIV seemed to be accompanied by an excess of deleterious inflammation that could promote these complications. The aims of this viewpoint paper are to summarize recent data and to examine the possibility that the problem of aging-related morbidity in HIV might not be as dramatic as previously believed...
June 15, 2018: Gerontology
https://www.readbyqxmd.com/read/29909359/effect-of-stirring-on-growth-and-cellulolytic-enzymes-production-by-trichoderma-harzianum-in-a-novel-bench-scale-solid-state-fermentation-bioreactor
#9
N Lopez-Ramirez, T Volke-Sepulveda, I Gaime-Perraud, G Saucedo-Castañeda, E Favela-Torres
A novel bench-scale stirred bioreactor for solid-state fermentation was used to determine the effect of the stirring rate on growth and enzymes production by Trichoderma harzianum PBLA. Lab-scale static tubular bioreactors were first used to assess the effect of bioreactor diameter on heat accumulation, growth, and production of cellulases and xylanases. The increased diameters (1.8-4.2 cm) led to increases in temperature up to 36 °C (at a rate of 1.08 °C/cm), which negatively affected the growth and enzyme production...
June 14, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29909315/effects-of-bisphenol-s-on-hypothalamic-neuropeptides-regulating-feeding-behavior-and-apelin-apj-system-in-mice
#10
Raja Rezg, Anne Abot, Bessem Mornagui, Samir Aydi, Claude Knauf
Since 2010, Bisphenol A (BPA), an endocrine disruptor has been restricted and replaced by analogues like Bisphenol S (BPS). However, little is known about BPS effects and growing concern have suspected the "BPA-free" Label. Several recent studies suggest that BPS is associated with increased risk of diabetes and obesity. However, the underlying mechanisms remain unidentified. The current study investigates investigate BPS effects on hypothalamic neuropeptides regulating feeding behavior, either orexigenic or anorexigenic in Swiss Albino mice...
June 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29909308/the-multilevel-antibiotic-induced-perturbations-to-biological-systems-early-life-exposure-induces-long-lasting-damages-to-muscle-structure-and-mitochondrial-metabolism-in-flies
#11
David Renault, Hesham Yousef, Amr A Mohamed
Antibiotics have been increasingly used over the past decades for human medicine, food-animal agriculture, aquaculture, and plant production. A significant part of the active molecules of antibiotics can be released into the environment, in turn affecting ecosystem functioning and biogeochemical processes. At lower organizational scales, these substances affect bacterial symbionts of insects, with negative consequences on growth and development of juveniles, and population dynamics. Yet, the multiple alterations of cellular physiology and metabolic processes have remained insufficiently explored in insects...
June 7, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29909261/temporal-relationships-of-gh-igf-i-and-fructosamine-concentrations-in-pregnant-spanish-purebred-mares-a-substantial-contribution-from-the-hormonal-standpoint
#12
K Satué, M Marcilla, P Medica, C Cravana, E Fazio
Growth hormone (GH) and insulin-like growth factor (IGF-I) exert essential functions to maintain an adequate metabolic activity for correct placental and fetal development. Although fructosamine (FRUCT) is used in clinical evaluation to assess the glycaemic state, the relationships between GH, IGF-I and FRUCT remain unknown in the mare. Therefore, the objectives of this study were to evaluate the relationships among these parameters in pregnant mares. A total of 30 healthy Spanish Purebred mares, with an age range of 9...
May 30, 2018: Theriogenology
https://www.readbyqxmd.com/read/29909237/glycosylation-as-new-pharmacological-strategies-for-diseases-associated-with-excessive-angiogenesis
#13
REVIEW
Simon Bousseau, Luisa Vergori, Raffaella Soleti, Guy Lenaers, M Carmen Martinez, Ramaroson Andriantsitohaina
Angiogenesis is a complex process describing the growth of new blood vessels from existing vasculature, and is triggered by local pro-angiogenic factors, such as vascular endothelial growth factor (VEGF), which increase the metabolism of endothelial cells (ECs). Angiogenesis takes part in various physiological conditions such as embryogenesis, placental growth, and in pathological conditions such as tumor growth, diabetic retinopathy, rheumatoid arthritis (RA) and ischemic diseases. Current therapies against excessive angiogenesis target vascular growth signaling...
June 14, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29909200/epigenetic-control-of-variation-and-stochasticity-in-metabolic-disease
#14
REVIEW
Ilaria Panzeri, John Andrew Pospisilik
BACKGROUND: The alarming rise of obesity and its associated comorbidities represents a medical burden and a major global health and economic issue. Understanding etiological mechanisms underpinning susceptibility and therapeutic response is of primary importance. Obesity, diabetes, and metabolic diseases are complex trait disorders with only partial genetic heritability, indicating important roles for environmental programing and epigenetic effects. SCOPE OF THE REVIEW: We will highlight some of the reasons for the scarce predictability of metabolic diseases...
May 18, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29909067/modulation-of-cholesterol-related-sterols-during-eimeria-bovis-macromeront-formation-and-impact-of-selected-oxysterols-on-parasite-development
#15
A Taubert, L M R Silva, Z D Velásquez, C Larrazabal, D Lütjohann, C Hermosilla
Obligate intracellular apicomplexan parasites are considered as deficient in cholesterol biosynthesis and scavenge cholesterol from their host cell in a parasite-specific manner. Compared to fast proliferating apicomplexan species producing low numbers of merozoites per host cell, (e. g. Toxoplasma gondii), the macromeront-forming protozoa Eimeria bovis is in extraordinary need for cholesterol for offspring production (≥ 170,000 merozoites I/macromeront). Interestingly, optimized in vitro E. bovis merozoite I production occurs under low foetal calf serum (FCS, 1...
June 14, 2018: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29909065/evaluation-of-kim-1-as-an-early-biomarker-of-snakebite-induced-aki-in-mice
#16
Rodrigo Tavares Dantas, Tiago Lima Sampaio, Dânya Bandeira Lima, Ramon Róseo Paula Pessoa Bezerra de Menezes, Jader Almeida Canuto, Marcos Hikari Toyama, Janaína Serra Azul Monteiro Evangelista, Alice Maria Costa Martins
Acute kidney injury (AKI) is one of the most important complications of bothropic poisoning and its early identification remains challenging. The nephrotoxicity of Bothrops insularis venom (BinsV) was previously described by our research group. In this study, we continued to evaluate the effect of BinsV on kidney function in mice and LLC-MK2 proximal tubule cells, evaluating KIM-1 protein as an early AKI biomarker. Male Swiss mice were inoculated with BinsV intramuscularly and observed for 24 h in a metabolic cage model...
June 14, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29909017/adropin-regulates-pyruvate-dehydrogenase-in-cardiac-cells-via-a-novel-gpcr-mapk-pdk4-signaling-pathway
#17
Dharendra Thapa, Michael W Stoner, Manling Zhang, Bingxian Xie, Janet R Manning, Danielle Guimaraes, Sruti Shiva, Michael J Jurczak, Iain Scott
Mitochondria supply ~90% of the ATP required for contractile function in cardiac cells. While adult cardiomyocytes preferentially utilize fatty acids as a fuel source for oxidative phosphorylation, cardiac mitochondria can switch to other substrates when required. This change is driven in part by a combination of extracellular and intracellular signal transduction pathways that alter mitochondrial gene expression and enzymatic activity. The mechanisms by which extracellular metabolic information is conveyed to cardiac mitochondria are not currently well defined...
June 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29909009/knockout-of-cnr1-prevents-metabolic-stress-induced-cardiac-injury-through-improving-insulin-resistance-ir-injury-and-endoplasmic-reticulum-er-stress-by-promoting-ampk-alpha-activation
#18
Su-Juan Pei, Huai-Yuan Zhu, Jin-Hui Guo, Xin Zhang, Zhi-Jian Deng
Obesity and diabetes are associated with diabetic cardiomyopathy (DCM). However, the pathogenesis of DCM is not fully understood. Cannabinoid receptor gene (CNR1) has been a drug target for the treatment of obesity. Here, we reported that CNR1 expression was increased in high fat diet (HFD)-induced heart of mice. Following, the wild type (CNR1+/+ ) and CNR1-knockout (CNR1-/- ) mice were employed and subjected to HFD treatments for 16 weeks to further investigate the effects of CNR1 on DCM. The results indicated that CNR1 knockout mice after HFD feeding exhibited a significant decrease of body weight and lipid accumulation in serum...
June 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29908987/monotropein-attenuates-ovariectomy-and-lps-induced-bone-loss-in-mice-and-decreases-inflammatory-impairment-on-osteoblast-through-blocking-activation-of-nf-%C3%AE%C2%BAb-pathway
#19
Yu-Qiong He, Hua Yang, Yi Shen, Jian-Hua Zhang, Zhi-Guo Zhang, Lin-Lin Liu, Hong-Tao Song, Bin Lin, Hsien-Yeh Hsu, Lu-Ping Qin, Ting Han, Hai-Liang Xin, Qiao-Yan Zhang
Estrogen deficiency and inflammation are known to play important roles in bone metabolism and occurrence of osteoporosis. Monotropein as an iridoid glycoside is reported to decrease estrogen deficiency-induced bone loss and inhibit inflammatory response in LPS-induced RAW 264.7 macrophages. However, the effect of monotropein on bone loss in chronic inflammatory conditions remains unclear. It was found in the present study that monotropein significantly inhibited bone mass reduction and improved bone micro-architectures by enhancing bone formation and blocking increased secretion of inflammatory cytokines in osteoporotic mice induced by combined ovariectomy and LPS...
June 14, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29908963/nonfunctional-mutant-wrn-protein-leads-to-neurological-deficits-neuronal-stress-microglial-alteration-and-immune-imbalance-in-a-mouse-model-of-werner-syndrome
#20
Chin Wai Hui, Marie-Kim St-Pierre, Jérôme Detuncq, Lucie Aumailley, Marie-Julie Dubois, Vanessa Couture, Daniel Skuk, André Marette, Jacques P Tremblay, Michel Lebel, Marie-Ève Tremblay
Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a shorter lifespan. Yet, little is known about the impact of WRN mutations on the central nervous system in both humans and mouse models of WS. In the current study, we have performed a longitudinal behavioral assessment on mice bearing a Wrn helicase deletion. Behavioral tests demonstrated a loss of motor activity and coordination, reduction in perception, increase in repetitive behavior, and deficits in both spatial and social novelty memories in Wrn mutant mice compared to age-matched wild type mice...
June 14, 2018: Brain, Behavior, and Immunity
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