keyword
https://read.qxmd.com/read/38547457/effect-of-hormone-therapy-on-lipoprotein-subfractions-in-early-and-late-postmenopausal-women
#1
JOURNAL ARTICLE
Intira Sriprasert, Stephanie S Kim, Iram Elias Mohammed, Naoko Kono, Roksana Karim, Hooman Allayee, Howard N Hodis, Wendy J Mack, Ronald M Krauss
CONTEXT: The Early vs Late Intervention Trial with Estradiol (ELITE) showed that hormone therapy (HT) reduced atherosclerosis progression among early but not late postmenopausal women (PMW). OBJECTIVE: Determined by time-since-menopause (1) HT effects on lipids and lipoprotein particle subfractions (LPs), (2) associations of estradiol (E2) level with lipids and LPs, (3) associations of lipids and LPs with atherosclerosis progression. DESIGN: Randomized controlled trial stratified by time-since-menopause...
March 28, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38547399/maternal-diabetes-and-fracture-risk-in-offspring-a-population-based-analysis
#2
JOURNAL ARTICLE
Viral N Shah, William D Leslie, Maria-Elena Lautatzis, Kun Liu, Heather J Prior, Brandy Wicklow
Factors affecting intrauterine environment exerts influence on skeletal health and fracture risk in later life. Diabetes during pregnancy is known to influence birth weight and is associated with fetal overgrowth. However, the effects of maternal diabetes on fracture risk in offspring is unknown. This study was aimed to evaluate the association between maternal diabetes and fracture risk in offspring. Using population-based administrative health data for Manitoba, Canada, we identified deliveries complicated by gestational diabetes and type 2 diabetes between April 1, 1980 and March 31, 2020...
March 28, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38547335/impact-of-iodine-supply-in-infancy-and-childhood
#3
JOURNAL ARTICLE
Dominique Turck
PURPOSE OF REVIEW: To assess the most relevant articles on the impact of iodine supply in at-risk populations, namely infants and young children, pregnant and lactating women. RECENT FINDINGS: The 2022 Iodine Global Network Annual Report confirmed the dramatic decrease of severe iodine deficiency over the last 30 years, thanks to universal iodine iodization. However, mild to moderate deficiency is still present in many countries, where recent data showed a decrease of iodine intake and an impairment of iodine status...
March 28, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547330/evidence-on-docosahexaenoic-acid-and-arachidonic-acid-supplementation-for-preterm-infants
#4
JOURNAL ARTICLE
Alexandre Lapillonne, Chiara Lembo, Sissel J Moltu
PURPOSE OF REVIEW: For many decades, docosahexaenoic acid (DHA) supplementation was tested in premature infants to achieve an intake equivalent to the average level in breast milk, but this approach has led to conflicting results in terms of development and health outcomes. Higher doses of DHA closer to fetal accumulation may be needed. RECENT FINDINGS: The efficacy of DHA supplementation for preterm infants at a dose equivalent to the estimated fetal accumulation rate is still under investigation, but this may be a promising approach, especially in conjunction with arachidonic acid supplementation...
March 18, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547323/sarcopenic-obesity-and-the-impact-on-bone-health
#5
JOURNAL ARTICLE
Silvia Migliaccio, Edoardo Mocini, Marianna Minnetti, Lorenzo Maria Donini
PURPOSE OF THE REVIEW: Sarcopenic obesity is a newly identified pathological entity defined by an increase in body fat mass with an associated sarcopenia, characterized by loss of muscle mass, strength, and function. Recently, the concomitant presence of skeletal alteration with sarcopenic obesity has been described leading to a new clinical entity defined osteosarcopenic obesity (OSO). Many studies have tried to unravel the metabolic complex mechanism leading to this clinical entity in order to understand the pathophysiology of this complex condition with the aim of posing an early diagnosis to improve the therapeutic approaches...
March 20, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547239/the-causal-effect-of-iron-status-on-risk-of-anxiety-disorders-a-two-sample-mendelian-randomization-study
#6
JOURNAL ARTICLE
Ruiying Yin, Qi Gao, Guangzhen Fu, Qiang Zhao
OBJECTIVES: Observational studies had investigated the association of iron metabolism with anxiety disorders. The conclusions were inconsistent and not available to reveal the causal or reverse-causal association due to the confounding. In this study we estimated the potential causal effect of iron homeostasis markers on anxiety disorders using two-sample Mendelian randomization (MR) analysis. METHODS: Summary data of single nucleotide polymorphisms (SNPs) associated with four iron-related biomarkers were extracted from a recent report about analysis of three genome-wide association study (GWAS), the sample size of which ranged from 131471 to 246139 individuals...
2024: PloS One
https://read.qxmd.com/read/38547234/transcriptome-wide-analysis-of-the-differences-between-mcf7-cells-cultured-in-dmem-or-%C3%AE-mem
#7
JOURNAL ARTICLE
Yang Jiao, Hongbo Zhao, Lin Lu, Xiangyu Zhao, Yanchun Wang, Bingrong Zheng
MCF7 cells have been used as an experimental model for breast cancer for decades. Typically, a culture medium is designed to supply cells with the nutrients essential for their continuous proliferation. Each medium has a specific nutritional composition. Therefore, cells cultured in different media may exhibit differences in their metabolism. However, only a few studies have investigated the effects of media on cells. In this study, we compared the effects of Dulbecco's modified Eagle medium (DMEM) and minimum essential medium alpha modification (αMEM) on MCF7 cells...
2024: PloS One
https://read.qxmd.com/read/38547201/similarity-and-dissimilarity-in-alterations-of-the-gene-expression-profile-associated-with-inhalational-anesthesia-between-sevoflurane-and-desflurane
#8
JOURNAL ARTICLE
Takehiro Nogi, Kousuke Uranishi, Ayumu Suzuki, Masataka Hirasaki, Tina Nakamura, Tomiei Kazama, Hiroshi Nagasaka, Akihiko Okuda, Tsutomu Mieda
Although sevoflurane is one of the most commonly used inhalational anesthetic agents, the popularity of desflurane is increasing to a level similar to that of sevoflurane. Inhalational anesthesia generally activates and represses the expression of genes related to xenobiotic metabolism and immune response, respectively. However, there has been no comprehensive comparison of the effects of sevoflurane and desflurane on the expression of these genes. Thus, we used a next-generation sequencing method to compare alterations in the global gene expression profiles in the livers of rats subjected to inhalational anesthesia by sevoflurane or desflurane...
2024: PloS One
https://read.qxmd.com/read/38547055/the-muc1-hif-1%C3%AE-signaling-axis-regulates-pancreatic-cancer-pathogenesis-through-polyamine-metabolism-remodeling
#9
JOURNAL ARTICLE
Divya Murthy, Kuldeep S Attri, Voddu Suresh, Girish H Rajacharya, Carlos A Valenzuela, Ravi Thakur, Junzhang Zhao, Surendra K Shukla, Nina V Chaika, Drew LaBreck, Chinthalapally V Rao, Michael A Hollingsworth, Kamiya Mehla, Pankaj K Singh
Dysregulation of polyamine metabolism has been implicated in cancer initiation and progression; however, the mechanism of polyamine dysregulation in cancer is not fully understood. In this study, we investigated the role of MUC1, a mucin protein overexpressed in pancreatic cancer, in regulating polyamine metabolism. Utilizing pancreatic cancer patient data, we noted a positive correlation between MUC1 expression and the expression of key polyamine metabolism pathway genes. Functional studies revealed that knockdown of spermidine/spermine N1-acetyltransferase 1 ( SAT1 ), a key enzyme involved in polyamine catabolism, attenuated the oncogenic functions of MUC1, including cell survival and proliferation...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38546975/insulin-transferrin-selenium-promote-formation-of-tissue-engineered-vascular-grafts-in-early-stage-of-culture
#10
JOURNAL ARTICLE
Xuheng Sun, Nannan Wang, Hongjing Jiang, Qing Liu, Cong Xiao, Jianyi Xu, Yindi Wu, Jingyi Mei, Shuting Wu, Zhanyi Lin
To create tissue-engineered vascular grafts (TEVGs) in vitro, vascular smooth muscle cells (VSMCs) must function effectively and produce sufficient extracellular matrix (ECM) in a three-dimensional space. In this study, we investigated whether the addition of insulin-transferrin-selenium (ITS), a medium supplement, could enhance TEVG formation. PGA fabric was used as the scaffold, and 1% ITS was added to the medium. After two weeks, the tissues were examined using electron microscopy and staining. The ITS group exhibited a denser structure and increased collagen production...
March 28, 2024: Preparative Biochemistry & Biotechnology
https://read.qxmd.com/read/38546974/multiomics-plasma-effects-of-switching-from-triple-antiretroviral-regimens-to-dolutegravir-plus-lamivudine
#11
JOURNAL ARTICLE
Elisa de Lazzari, Eugenia B Negredo, Pere Domingo, Juan M Tiraboschi, Esteve Ribera, Nadia Abdulghani, Verònica Alba, Salvador Fernández-Arroyo, Consuelo Viladés, Joaquim Peraire, Jose M Gatell, Jose L Blanco, Francesc Vidal, Anna Rull, Esteban Martinez
INTRODUCTION: The DOLAM trial revealed that switching from triple antiretroviral therapy (three-drug regimen; 3DR) to dolutegravir plus lamivudine (two-drug regimen; 2DR) was virologically non-inferior to continuing 3DR after 48 weeks of follow-up. Weight increased with 2DR relative to 3DR but it did not impact on metabolic parameters. METHODS: Multiomics plasma profile was performed to gain further insight into whether this therapy switch might affect specific biological pathways...
March 28, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38546940/effect-of-a-single-small-volume-fluid-bolus-with-balanced-or-un-balanced-fluids-on-chloride-and-acid-base-status-a-prospective-randomized-pilot-study-the-flures-trial
#12
JOURNAL ARTICLE
M Raes, J A Kellum, R Colman, S Wallaert, M Crivits, F Viaene, M Hemeryck, D Benoit, J Poelaert, E Hoste
OBJECTIVE: To compare the short-term effects on acid base, electrolyte status and urine output of a single fluid bolus of saline to that of the balanced solution Plasmalyte® in critically ill patients. METHODS: Prospective, randomized, controlled trial. Adult patients (≥ 18 years) admitted to the ICU receiving a fluid bolus were randomized to receive 1 L of saline (NaCl 0.9%, Baxter) or a balanced fluid [Plasmalyte® (Baxter)]. Blood samples and urine output were collected just before (T0), just after (T1), 2 h after (T2) (only for urinary output) and three hours after termination of the fluid bolus (T4)...
March 28, 2024: Journal of Nephrology
https://read.qxmd.com/read/38546901/evaluating-left-atrial-function-changes-by-speckle-tracking-echocardiography-in-type-2-diabetes-patients-in-central-vietnam-a-cross-sectional-comparative-study
#13
JOURNAL ARTICLE
Hai Nguyen Ngoc Dang, Thang Viet Luong, Toan Thanh Tran
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a metabolic disorder that detrimentally affects multiple systems in the body, with a particular emphasis on the vascular and nervous systems. Despite its significant impact, limited studies have explored the influence of this condition on the left atrial (LA) function. To address this gap, our study utilized speckle tracking echocardiography (STE) to assess LA function in patients with T2DM in Central Vietnam. RESULTS: The cross-sectional comparative study enrolled 134 subjects involving 66 patients with T2DM and 68 healthy individuals meeting the selection and exclusion criteria of the study...
March 28, 2024: Egyptian Heart Journal: EHJ
https://read.qxmd.com/read/38546831/physiological-appetite-regulation-and-bariatric-surgery
#14
REVIEW
Indra Ramasamy
Obesity remains a common metabolic disorder and a threat to health as it is associated with numerous complications. Lifestyle modifications and caloric restriction can achieve limited weight loss. Bariatric surgery is an effective way of achieving substantial weight loss as well as glycemic control secondary to weight-related type 2 diabetes mellitus. It has been suggested that an anorexigenic gut hormone response following bariatric surgery contributes to weight loss. Understanding the changes in gut hormones and their contribution to weight loss physiology can lead to new therapeutic treatments for weight loss...
February 27, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38546817/differences-between-cultured-astrocytes-from-neonatal-and-adult-wistar-rats-focus-on-in-vitro%C3%A2-aging-experimental-models
#15
JOURNAL ARTICLE
Fernanda Becker Weber, Camila Leite Santos, Amanda da Silva, Izaviany Schmitz, Ester Rezena, Carlos-Alberto Gonçalves, André Quincozes-Santos, Larissa Daniele Bobermin
Astrocytes play key roles regulating brain homeostasis and accumulating evidence has suggested that glia are the first cells that undergo functional changes with aging, which can lead to a decline in brain function. In this context, in vitro models are relevant tools for studying aged astrocytes and, here, we investigated functional and molecular changes in cultured astrocytes obtained from neonatal or adult animals submitted to an in vitro model of aging by an additional period of cultivation of cells after confluence...
March 28, 2024: In Vitro Cellular & Developmental Biology. Animal
https://read.qxmd.com/read/38546526/enhanced-chronic-inflammation-and-increased-branched-chain-amino-acids-in-adrenal-disorders-a-cross-sectional-study
#16
JOURNAL ARTICLE
Annop Kittithaworn A, Prerna Dogra, Jasmine Saini, Eke G Gruppen, Elizabeth Atkinson, Sara Achenbach, Kai Yu, Karthik Thangamuthu, Margery A Connelly, Robin Pf Dullaart, Irina Bancos
CONTEXT: Patients with adrenal hormone excess demonstrate increased cardiovascular risk and mortality. OBJECTIVE: We aimed to determine the impact of adrenal disorders on the inflammation marker GlycA, total branched-chain amino acids (BCAA), ketone bodies and the gut microbiome-derived metabolites trimethylamine N-oxide (TMAO) and betaine. METHODS: We conducted a single-center cross-sectional study of patients with nonfunctioning adenomas (NFA), mild autonomous cortisol secretion (MACS), primary aldosteronism (PA), Cushing syndrome (CS), pheochromocytoma/paragangliomas (PPGL), other benign or malignant adrenal masses, and adrenocortical carcinoma (ACC) between January 2015 and July 2022 (n=802)...
March 28, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38546454/increased-nitrate-intake-from-beetroot-juice-over-4-weeks-affects-nitrate-metabolism-but-not-vascular-function-or-blood-pressure-in-older-adults-with-hypertension
#17
JOURNAL ARTICLE
Rebeka Fejes, Martin Lutnik, Stefan Weisshaar, Nina Pilat, Karl-Heinz Wagner, Hans-Peter Stüger, Jonathan M Peake, Richard J Woodman, Kevin D Croft, Catherine P Bondonno, Jonathan M Hodgson, Michael Wolzt, Oliver Neubauer
The decline in vascular function and increase in blood pressure with aging contribute to an increased cardiovascular disease risk. In this randomized placebo-controlled crossover study, we evaluated whether previously reported cardiovascular benefits of plant-derived inorganic nitrate via nitric oxide (NO) translate into improved vascular function and blood pressure-lowering in 15 men and women (age range: 56-71 years) with treated hypertension. We investigated the effects of a single ∼400 mg-dose at 3 hours post-ingestion (3H POST) and the daily consumption of 2 × ∼400 mg of nitrate through nitrate-rich compared with nitrate-depleted (placebo) beetroot juice over 4 weeks (4WK POST)...
March 28, 2024: Food & Function
https://read.qxmd.com/read/38546383/value-of-serum-iron-and-urine-neutrophil-gelatinase-associated-lipocalin-in-predicting-the-mortality-of-critically-ill-patients-with-sepsis
#18
JOURNAL ARTICLE
Rui Zhao, Jiang-Hua Liu, Ze-Liang Qiu
INTRODUCTION: We aimed to investigate the association of iron metabolism-related parameters with 60-day mortality in critically ill patients with sepsis. METHODS: Serum or urine concentrations of iron metabolism-related parameters on intensive care unit admission were measured in a prospective cohort of 133 eligible patients with sepsis according to the Sepsis-3 criteria, and these values were compared between survivors and nonsurvivors, categorized according to their 60-day survival status...
March 1, 2024: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/38546323/review-and-meta-analysis-of-the-genetic-minimal-cut-set-approach-for-gene-essentiality-prediction-in-cancer-metabolism
#19
JOURNAL ARTICLE
Danel Olaverri-Mendizabal, Luis V Valcárcel, Naroa Barrena, Carlos J Rodríguez, Francisco J Planes
Cancer metabolism is a marvellously complex topic, in part, due to the reprogramming of its pathways to self-sustain the malignant phenotype in the disease, to the detriment of its healthy counterpart. Understanding these adjustments can provide novel targeted therapies that could disrupt and impair proliferation of cancerous cells. For this very purpose, genome-scale metabolic models (GEMs) have been developed, with Human1 being the most recent reconstruction of the human metabolism. Based on GEMs, we introduced the genetic Minimal Cut Set (gMCS) approach, an uncontextualized methodology that exploits the concepts of synthetic lethality to predict metabolic vulnerabilities in cancer...
March 27, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38546267/the-staphylococcus-aureus-regulatory-program-in-a-human-skin-like-environment
#20
JOURNAL ARTICLE
Flavia G Costa, Krista B Mills, Heidi A Crosby, Alexander R Horswill
UNLABELLED: Staphylococcus aureus is a Gram-positive pathogen responsible for the majority of skin and soft tissue infections (SSTIs). S. aureus colonizes the anterior nares of approximately 20%-30% of the population and transiently colonizes the skin, thereby increasing the risk of developing SSTIs and more serious infections. Current laboratory models that mimic the skin surface environment are expensive, require substantial infrastructure, and limit the scope of bacterial physiology studies under human skin conditions...
March 28, 2024: MBio
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