Divya Murthy, Kuldeep S Attri, Voddu Suresh, Girish H Rajacharya, Carlos A Valenzuela, Ravi Thakur, Junzhang Zhao, Surendra K Shukla, Nina V Chaika, Drew LaBreck, Chinthalapally V Rao, Michael A Hollingsworth, Kamiya Mehla, Pankaj K Singh
Dysregulation of polyamine metabolism has been implicated in cancer initiation and progression; however, the mechanism of polyamine dysregulation in cancer is not fully understood. In this study, we investigated the role of MUC1, a mucin protein overexpressed in pancreatic cancer, in regulating polyamine metabolism. Utilizing pancreatic cancer patient data, we noted a positive correlation between MUC1 expression and the expression of key polyamine metabolism pathway genes. Functional studies revealed that knockdown of spermidine/spermine N1-acetyltransferase 1 ( SAT1 ), a key enzyme involved in polyamine catabolism, attenuated the oncogenic functions of MUC1, including cell survival and proliferation...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America