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https://www.readbyqxmd.com/read/29055172/evaluation-of-the-antioxidant-impact-of-ginger-based-kombucha-on-the-murine-breast-cancer-model
#1
Samaneh Salafzoon, Hamideh Mahmoodzadeh Hosseini, Raheleh Halabian
Background Abnormal metabolism is a common event in cancerous cells. For example, the increase of reactive oxygen species (ROS) production, particularly due to aerobic respiration during invasive stage, results in cancer progression. Herein, the impact of kombucha tea prepared from ginger on the alteration of antioxidant agents was assessed in the breast cancer animal model. Methods Two types of kombucha tea with or without ginger were administered to BALB/c mice before and after tumor challenge. Superoxide dismutase (SOD), catalase, glutathione (GSH) and malondialdehyde (MDA) were evaluated in tumor, liver and kidney...
October 21, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29055022/the-addition-of-a-developmental-factor-unc-62-to-already-long-lived-worms-increases-lifespan-and-healthspan
#2
Dror Sagi
Aging is a complex trait that is affected by multiple genetic pathways. A relatively unexplored approach is to manipulate multiple independent aging pathways simultaneously in order to observe their cumulative effect on lifespan. Here, we report the phenotypic characterization of a strain with changes in five aging pathways: 1) mitochondrial ROS production, 2) innate immunity, 3) stress response, 4) metabolic control and 5) developmental regulation in old age. The quintuply-modified strain has a lifespan that is 160% longer than the transgenic control strain...
October 20, 2017: Biology Open
https://www.readbyqxmd.com/read/29054976/regulation-of-insulin-like-growth-factor-receptors-by-ubiquilin1
#3
Zimple Kurlawala, Rain Dunaway, Parag P Shah, Julie A Gosney, Leah J Siskind, Brian P Ceresa, Levi J Beverly
Insulin-like growth factor-1 receptor (IGF1R) is a receptor tyrosine kinase that mediates growth, proliferation and survival. Dysregulation of IGF pathway contributes to initiation, progression and metastasis of cancer and is also involved in diseases of glucose metabolism, such as Diabetes. We have identified Ubiquilin1 (UBQLN1) as a novel interaction partner of IGF1R, IGF2R and Insulin Receptor. UBQLN family of proteins have been studied primarily in the context of protein quality control and in the field of neurodegenerative disorders...
October 20, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29054973/chronic-femoral-artery-ligation-exaggerates-the-pressor-and-sympathetic-nerve-responses-during-dynamic-skeletal-muscle-stretch-in-decerebrate-rats
#4
Evan A Kempf, Korynne S Rollins, Tyler D Hopkins, Alec L Butenas, Joseph M Santin, Joshua R Smith, Steven W Copp
Mechanical and metabolic signals arising during skeletal muscle contraction reflexly increase sympathetic nerve activity and blood pressure (i.e., the exercise pressor reflex). In a rat model of simulated peripheral artery disease (PAD) in which a femoral artery is chronically (~72 hours) ligated, the mechanically-sensitive component of the exercise pressor reflex during 1 Hz dynamic contraction is exaggerated compared to that found in normal rats. Whether this is due to an enhanced acute sensitization of mechanoreceptors by metabolites produced during contraction or involves a chronic sensitization of mechanoreceptors is unknown...
October 20, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29054870/synthesis-of-heterologous-mevalonic-acid-pathway-enzymes-in-clostridium-ljungdahlii-for-the-conversion-of-fructose-and-of-syngas-to-mevalonate-and-isoprene
#5
Bruce A Diner, Janine Fan, Miles C Scotcher, Derek H Wells, Gregory M Whited
There is a growing interest in the use of microbial fermentation for the generation of high-demand, high-purity chemicals using cheap feedstocks, in an environmentally-friendly manner. One example explored here is the production of isoprene (C5H8), a hemiterpene, which is primarily polymerized to polyisoprene in synthetic rubber in tires, but which can also be converted to C10 and C15 biofuels.The strictly anaerobic, acetogenic bacterium Clostridium ljungdahlii, used in all of the work described here, is capable of glycolysis using the Emben-Meyerhof-Parnas pathway and of carbon fixation using the Wood-Ljungdahl pathway...
October 20, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29054862/current-evidence-based-recommendations-on-investigating-children-with-global-developmental-delay
#6
REVIEW
Renuka Mithyantha, Rachel Kneen, Emma McCann, Melissa Gladstone
INTRODUCTION: Global developmental delay (GDD) affects 1%-3% of the population of children under 5 years of age, making it one of the most common conditions presenting in paediatric clinics; causes are exogenous, genetic (non-metabolic) or genetic (metabolic). Recent advances in biotechnology and genetic testing mean that the investigations available to perform for children under 5 years are increasing and are more sensitive than previously. This change in availability and type of testing necessitates an update in the recommendations for investigating GDD...
November 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29054807/ontogeny-of-skeletal-and-cardiac-muscle-mitochondria-oxygen-fluxes-in-two-breeds-of-chicken
#7
Sarah K G Sirsat, Edward M Dzialowski
From its earliest days of domestication, the domestic chicken (Gallus gallus domesticus) has been selectively bred for specific traits. Decades of genetic selection have resulted in significant dissimilarities in metabolism and growth between breeds, in particular fast-growing broilers and highly productive layers. A chicken develops the capacity to elevate metabolism in response to decreases in ambient temperature upon hatching, including well-developed methods of regulating thermogenesis. However, a differential timing between incipient endothermic capacities of broiler and layer strains exists...
October 17, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29054798/the-antimicrobial-peptide-nisin-z-induces-selective-toxicity-and-apoptotic-cell-death-in-cultured-melanoma-cells
#8
Angélique Lewies, Johannes Frederik Wentzel, Hayley van Dyk, Lissinda Hester Du Plessis
Reprogramming of cellular metabolism is now considered one of the hallmarks of cancer. Most malignant cells Reprogramming of cellular metabolism is now considered one of the hallmarks of cancer. Most malignant cells present with altered energy metabolism which is associated with elevated reactive oxygen species (ROS) generation. This is also evident for melanoma, the leading cause of skin cancer related deaths. Altered mechanisms affecting mitochondrial bioenergetics pose attractive targets for novel anti-cancer therapies...
October 17, 2017: Biochimie
https://www.readbyqxmd.com/read/29054764/trpm8-activation-improves-energy-expenditure-in-skeletal-muscle-and-exercise-endurance-in-mice
#9
Chen Li, Jia Li, Xiujuan Xiong, Ying Liu, Yanxia Lv, Shanshan Qin, Dandan Liu, Ronghua Wei, Xuzhi Ruan, Jingxuan Zhang, Liang Xu, Xuanbin Wang, Jicheng Chen, Yonghong Zhang, Lanlan Zheng
Skeletal muscle serving as the major organ is responsible for energy expenditure and exercise endurance, which directly influence cardiometabolic risk factors. Transient receptor potential melastatin 8 (TRPM8), a Ca(2+)-permeable non-selective cation channel, plays vital roles in the regulation of various cellular functions. It has been reported that TRPM8 activation enhanced the energy metabolism of adipocytes. However, the involvement of TRPM8 in the energy metabolism of skeletal muscle remains unexplored...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29054721/characterizing-the-association-between-toll-like-receptor-subtypes-and-nephrolithiasis-with-renal-inflammation-in-an-animal-model
#10
Mahmut Taha Olcucu, Kerem Teke, Serdar Yalcin, Erkan Olcucuoglu, Vildan Caner, Nilay Sen Turk, Omer Levent Tuncay
OBJECTIVES: To show experimentally induced renal stone disease and evaluate secondary inflammatory responses in vivo, and to characterize changes in expression of Toll-like receptor (TLR) subtypes in this model. To evaluate the associations of hyperoxaluria-induced renal stone formation and Toll-like receptors (TLRs) expression in a rat inflammation model. METHODS: Twenty 5-6-week-old male Wistar rats were divided into control and hyperoxaluria groups (n=10/group) and supplied with normal water or 1% ethylene glycol, respectively, for 16 weeks...
October 17, 2017: Urology
https://www.readbyqxmd.com/read/29054673/fluvial-biofilms-exposed-to-desiccation-and-pharmaceutical-pollution-new-insights-using-metabolomics
#11
Albert Serra-Compte, Natàlia Corcoll, Belinda Huerta, Sara Rodríguez-Mozaz, Sergi Sabater, Damià Barceló, Diana Álvarez-Muñoz
In many arid and semi-arid systems, biological communities in river ecosystems are submitted to flow interruption and desiccation, as well as to the impact of urban wastewaters. In this work, we studied (using a LC-LTQ-Orbitrap) the metabolomic response of biofilm communities exposed to both hydrological and chemical stressors. Fluvial biofilms were exposed to a mixture of 9 pharmaceuticals at a total concentration of 5000ng/L (mimicking concentrations and compounds found in polluted aquatic environments) and/or to seven days of desiccation, under laboratory conditions...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054661/coordinated-role-of-soluble-and-cell-wall-bound-phenols-is-a-key-feature-of-the-metabolic-adjustment-in-a-mining-woody-fleabane-dittrichia-viscosa-l-population-under-semi-arid-conditions
#12
Antonio López-Orenes, María C Bueso, Isabel M Párraga-Aguado, Antonio A Calderón, María A Ferrer
Environmental contamination by hazardous heavy metals/metalloids (metal(loid)s) is growing worldwide. To restrict the migration of toxic contaminants, the establishment of a self-sustainable plant cover is required. Plant growth in multi-polluted soils is a challenging issue not only by metal(loid) toxicities, but also by the co-occurrence of other stressors. Dittrichia viscosa is a pioneer Mediterranean species able to thrive in metal(loid)-enriched tailings in semi-arid areas. The aim of the present work was to examine the metabolic adjustments involved in the acclimation responses of this plant to conditions prevailing in mine-tailings during Mediterranean spring and summer...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054655/association-of-serum-levels-of-perfluoroalkyl-substances-pfass-with-the-metabolic-syndrome-mets-in-chinese-male-adults-a-cross-sectional-study
#13
Qiaoyun Yang, Xiaoli Guo, Pengling Sun, Yujiao Chen, Wei Zhang, Ai Gao
As extensively used chemicals in a variety of consumer products, perfluoroalkyl substances (PFASs) are ubiquitous and could bring significant risk to human health. However, the effect of PFASs on metabolic syndrome (MetS) is not fully understood. In 2015, a preliminary cross-sectional study was undertaken. A total of 148 male subjects including 81 affected by MetS and 67 non-MetS participants as the reference were recruited from Physical Examination Center affiliated to Capital Medical University, China. Serum levels of perfluorohexane sulfonic acid (PFHxS), perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) were significantly higher in the subjects with MetS...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054582/characterization-and-functional-analysis-of-a-carboxylesterase-gene-associated-with-chlorpyrifos-resistance-in-nilaparvata-lugens-st%C3%A3-l
#14
Kai Lu, Ying Wang, Xia Chen, Zhichao Zhang, Yue Li, Wenru Li, Qiang Zhou
The widespread and extensive application of insecticides have promoted the development of resistance in the brown planthopper Nilaparvata lugens (Stål), one of the most important rice pests in Asia. To better understand the underlying molecular mechanisms of metabolic resistance to insecticides, a chlorpyrifos-resistant (CR) strain of N. lugens was selected and its possible resistance mechanism was investigated. Synergistic tests using carboxylesterases (CarEs) inhibitor triphenyl phosphate (TPP) decreased the resistance of N...
October 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29054470/circulating-adiponectin-increases-in-obese-women-after-sleeve-gastrectomy-or-gastric-bypass-driving-beneficial-metabolic-changes-but%C3%A2-with-no-relationship-with-carotid-intima-media-thickness
#15
Jesús M Gómez-Martin, José A Balsa, Enrique Aracil, María Insenser, Pablo Priego, Héctor F Escobar-Morreale, José I Botella-Carretero
BACKGROUND & AIMS: Obesity surgery induces beneficial effects in metabolic and cardiovascular parameters. Adiponectin increase might be associated with some of these changes. However, direct comparison between different surgical techniques has not been extensively performed. METHODS: We studied 20 obese women submitted to laparoscopic Roux en Y gastric bypass (RYGB) and 20 to sleeve gastrectomy (SG). Twenty control women matched for age and baseline metabolic profiles were also included...
October 12, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29054417/the-regulation-of-pathways-of-inflammation-and-resolution-in-immune-cells-and-cancer-stem-cells-by-selenium
#16
Bastihalli T Diwakar, Arvind M Korwar, Robert F Paulson, K Sandeep Prabhu
Cancer is a complex disease where cancer stem cells (CSCs) maintain unlimited replicative potential, but evade chemotherapy drugs through cellular quiescence. CSCs are able to give rise to bulk tumor cells that have the capability to override antiproliferative signals and evade apoptosis. Numerous pathways are dysregulated in tumor cells, where increased levels of prooxidant reactive oxygen and nitrogen species can lead to localized inflammation to exacerbate all three stages of tumorigenesis: initiation, progression, and metastasis...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/29054397/tolerance-in-clinical-liver-transplantation
#17
REVIEW
Josh Levitsky, Sandy Feng
While advances in immunosuppressive therapy have lowered the rate of acute rejection following liver transplantation, the consequence has been an increase in morbidity and mortality related to the lifelong need for maintenance immunosuppression. These complications include an increased risk of malignancy, infection, metabolic disorders, and chronic kidney disease, as well as high health care costs associated with these therapies and the required drug monitoring. Given these issues, most clinicians attempt trial and error dose minimization with variable success rates, and there has been significant interest in full drug withdrawal in select patients through research protocols...
October 17, 2017: Human Immunology
https://www.readbyqxmd.com/read/29054049/individual-variability-in-clinical-effect-and-tolerability-of-opioid-analgesics-importance-of-drug-interactions-and-pharmacogenetics
#18
REVIEW
Vigdis Solhaug, Espen Molden
BACKGROUND: As pain is often a comorbid condition, many patients use opioid analgesics in combination with several other drugs. This implies a generally increased risk of drug interactions, which along with inherent pharmacogenetic variability and other factors may cause differences in therapeutic response of opioids. AIM: To provide an overview of interactions and pharmacogenetic variability of relevance for individual differences in effect and tolerability of opioid analgesics, which physicians and other healthcare professionals should be aware of in clinical practice...
October 17, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29053995/effects-of-a-whey-protein-supplementation-on-oxidative-stress-body-composition-and-glucose-metabolism-among-overweight-people-affected-by-diabetes-mellitus-or-impaired-fasting-glucose-a-pilot-study
#19
Chiara Flaim, Michael Kob, Angela M Di Pierro, Markus Herrmann, Lucio Lucchin
Obesity and diabetes mellitus type 2 (DM2) are characterized by chronic inflammation and oxidative stress [Donath et al. 2013] and this leads to cardiovascular diseases [Hulsmans & Holvoet 2010]. Whey proteins (WP) have antioxidant [Chitapanarux et al. 2009], anti-inflammatory [Sugawara et al. 2012] and hypoglycemic activities [Mignone et al. 2015], while data on weight, body composition [Frestedt et al. 2008; Aldrich et al. 2011] and blood pressure are conflicting [Kawase et al. 2000; Lee et al. 2007]. WP have unpleasant taste and smell [Patel 2015], but a new WP isolate (ProLYOtin®) seems to be more palatable...
May 20, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29053957/cdk4-phosphorylates-ampk%C3%AE-2-to-inhibit-its-activity-and-repress-fatty-acid-oxidation
#20
Isabel C Lopez-Mejia, Sylviane Lagarrigue, Albert Giralt, Laia Martinez-Carreres, Nadège Zanou, Pierre-Damien Denechaud, Judit Castillo-Armengol, Carine Chavey, Meritxell Orpinell, Brigitte Delacuisine, Anita Nasrallah, Caterina Collodet, Lianjun Zhang, Benoît Viollet, D Grahame Hardie, Lluis Fajas
The roles of CDK4 in the cell cycle have been extensively studied, but less is known about the mechanisms underlying the metabolic regulation by CDK4. Here, we report that CDK4 promotes anaerobic glycolysis and represses fatty acid oxidation in mouse embryonic fibroblasts (MEFs) by targeting the AMP-activated protein kinase (AMPK). We also show that fatty acid oxidation (FAO) is specifically induced by AMPK complexes containing the α2 subunit. Moreover, we report that CDK4 represses FAO through direct phosphorylation and inhibition of AMPKα2...
October 19, 2017: Molecular Cell
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