Philipp Alexander Loehrer, Wibke Schumacher, Stefanie T Jost, Monty Silverdale, Jan Niklas Petry-Schmelzer, Anna Sauerbier, Alexandra Gronostay, Veerle Visser-Vandewalle, Gereon R Fink, Julian Evans, Max Krause, Alexandra Rizos, Angelo Antonini, Keyoumars Ashkan, Pablo Martinez-Martin, Christian Gaser, K Ray Chaudhuri, Lars Timmermann, Juan Carlos Baldermann, Haidar S Dafsari
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy in advanced Parkinson's disease (PD). Motor and non-motor outcomes, however, show considerable inter-individual variability. Preoperative morphometry-based metrics have recently received increasing attention to explain treatment effects. As evidence for the prediction of non-motor outcomes is limited, we sought to investigate the association between metrics of voxel-based morphometry and short-term non-motor outcomes following STN-DBS in this prospective open-label study...
April 26, 2024: NPJ Parkinson's Disease