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Brain Morphometry

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https://www.readbyqxmd.com/read/28428742/a-set-based-mixed-effect-model-for-gene-environment-interaction-and-its-application-to-neuroimaging-phenotypes
#1
Changqing Wang, Jianping Sun, Bryan Guillaume, Tian Ge, Derrek P Hibar, Celia M T Greenwood, Anqi Qiu
Imaging genetics is an emerging field for the investigation of neuro-mechanisms linked to genetic variation. Although imaging genetics has recently shown great promise in understanding biological mechanisms for brain development and psychiatric disorders, studying the link between genetic variants and neuroimaging phenotypes remains statistically challenging due to the high-dimensionality of both genetic and neuroimaging data. This becomes even more challenging when studying gene-environment interaction (G×E) on neuroimaging phenotypes...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28425061/gray-matter-and-white-matter-changes-in-non-demented-amyotrophic-lateral-sclerosis-patients-with-or-without-cognitive-impairment-a-combined-voxel-based-morphometry-and-tract-based-spatial-statistics-whole-brain-analysis
#2
Foteini Christidi, Efstratios Karavasilis, Franz Riederer, Ioannis Zalonis, Panagiotis Ferentinos, Georgios Velonakis, Sophia Xirou, Michalis Rentzos, Georgios Argiropoulos, Vasiliki Zouvelou, Thomas Zambelis, Athanasios Athanasakos, Panagiotis Toulas, Konstantinos Vadikolias, Efstathios Efstathopoulos, Spyros Kollias, Nikolaos Karandreas, Nikolaos Kelekis, Ioannis Evdokimidis
The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients show structural changes within but also beyond the motor cortex and corticospinal tract and furthermore outside the frontal lobes, even if frank dementia is not detected. The aim of the present study was to investigate both gray matter (GM) and white matter (WM) changes in non-demented amyotrophic lateral sclerosis (ALS) patients with or without cognitive impairment (ALS-motor and ALS-plus, respectively). Nineteen ALS-motor, 31 ALS-plus and 25 healthy controls (HC) underwent 3D-T1-weighted and 30-directional diffusion-weighted imaging on a 3 T MRI scanner...
April 19, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28420876/examining-gray-matter-structure-associated-with-academic-performance-in-a-large-sample-of-chinese-high-school-students
#3
Song Wang, Ming Zhou, Taolin Chen, Xun Yang, Guangxiang Chen, Meiyun Wang, Qiyong Gong
Achievement in school is crucial for students to be able to pursue successful careers and lead happy lives in the future. Although many psychological attributes have been found to be associated with academic performance, the neural substrates of academic performance remain largely unknown. Here, we investigated the relationship between brain structure and academic performance in a large sample of high school students via structural magnetic resonance imaging (S-MRI) using voxel-based morphometry (VBM) approach...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417971/greater-cerebellar-gray-matter-volume-in-car-drivers-an-exploratory-voxel-based-morphometry-study
#4
Hiroyuki Sakai, Takafumi Ando, Norihiro Sadato, Yuji Uchiyama
Previous functional neuroimaging studies have identified multiple brain areas associated with distinct aspects of car driving in simulated traffic environments. Few studies, however, have examined brain morphology associated with everyday car-driving experience in real traffic. Thus, the aim of the current study was to identify gray matter volume differences between drivers and non-drivers. We collected T1-weighted structural brain images from 73 healthy young adults (36 drivers and 37 non-drivers). We performed a whole-brain voxel-based morphometry analysis to examine between-group differences in regional gray matter volume...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28412941/survival-prediction-in-amyotrophic-lateral-sclerosis-based-on-mri-measures-and-clinical-characteristics
#5
Christina Schuster, Orla Hardiman, Peter Bede
BACKGROUND: Amyotrophic lateral sclerosis (ALS) a highly heterogeneous neurodegenerative condition. Accurate diagnostic, monitoring and prognostic biomarkers are urgently needed both for individualised patient care and clinical trials. A multimodal magnetic resonance imaging study is presented, where MRI measures of ALS-associated brain regions are utilised to predict 18-month survival. METHODS: A total of 60 ALS patients and 69 healthy controls were included in this study...
April 17, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28408879/comparison-of-in-vivo-and-ex-vivo-mri-for-the-detection-of-structural-abnormalities-in-a-mouse-model-of-tauopathy
#6
Holly E Holmes, Nick M Powell, Da Ma, Ozama Ismail, Ian F Harrison, Jack A Wells, Niall Colgan, James M O'Callaghan, Ross A Johnson, Tracey K Murray, Zeshan Ahmed, Morten Heggenes, Alice Fisher, M Jorge Cardoso, Marc Modat, Michael J O'Neill, Emily C Collins, Elizabeth M C Fisher, Sébastien Ourselin, Mark F Lythgoe
With increasingly large numbers of mouse models of human disease dedicated to MRI studies, compromises between in vivo and ex vivo MRI must be fully understood in order to inform the choice of imaging methodology. We investigate the application of high resolution in vivo and ex vivo MRI, in combination with tensor-based morphometry (TBM), to uncover morphological differences in the rTg4510 mouse model of tauopathy. The rTg4510 mouse also offers a novel paradigm by which the overexpression of mutant tau can be regulated by the administration of doxycycline, providing us with a platform on which to investigate more subtle alterations in morphology with morphometry...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28406379/the-neural-basis-of-independence-versus-interdependence-orientations-a-voxel-based-morphometric-analysis-of-brain-volume
#7
Fei Wang, Kaiping Peng, Magdalena Chechlacz, Glyn W Humphreys, Jie Sui
Sociocultural research has established independence and interdependence as two fundamental ways of thinking about oneself and the social world. Recent neuroscience studies further demonstrate that these orientations modulate brain activity in various self- and socially related tasks. In the current study, we explored whether the traits of independence and interdependence are reflected in anatomical variations in brain structure. We carried out structural brain imaging on a large sample of healthy participants ( n = 265) who also completed self-report questionnaires of cultural orientations...
April 2017: Psychological Science
https://www.readbyqxmd.com/read/28403239/simulated-blast-overpressure-induces-specific-astrocyte-injury-in-an-ex-vivo-brain-slice-model
#8
Saranya Canchi, Malisa Sarntinoranont, Yu Hong, Jeremy J Flint, Ghatu Subhash, Michael A King
Exposure to explosive blasts can produce functional debilitation in the absence of brain pathology detectable at the scale of current diagnostic imaging. Transient (ms) overpressure components of the primary blast wave are considered to be potentially damaging to the brain. Astrocytes participate in neuronal metabolic maintenance, blood-brain barrier, regulation of homeostatic environment, and tissue remodeling. Damage to astrocytes via direct physical forces has the potential to disrupt local and global functioning of neuronal tissue...
2017: PloS One
https://www.readbyqxmd.com/read/28399433/embodied-emotion-impairment-in-huntington-s-disease
#9
Iris Trinkler, Sévérine Devignevielle, Amal Achaibou, Romain V Ligneul, Pierre Brugières, Laurent Cleret de Langavant, Beatrice De Gelder, Rachael Scahill, Sophie Schwartz, Anne-Catherine Bachoud-Lévi
Theories of embodied cognition suggest that perceiving an emotion involves somatovisceral and motoric re-experiencing. Here we suggest taking such an embodied stance when looking at emotion processing deficits in patients with Huntington's Disease (HD), a neurodegenerative motor disorder. The literature on these patients' emotion recognition deficit has recently been enriched by some reports of impaired emotion expression. The goal of the study was to find out if expression deficits might be linked to a more motoric level of impairment...
March 18, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28396646/regional-gray-matter-volume-is-associated-with-restrained-eating-in-healthy-chinese-young-adults-evidence-from-voxel-based-morphometry
#10
Yanhua Su, Todd Jackson, Dongtao Wei, Jiang Qiu, Hong Chen
Highlight Participants were non-clinical young adults with different restrained eating levels.We assessed relations of restrained eating (RE) with regional gray matter volume (rGMV).High RE scores were related to larger GMV in specific areas related to reward.High RE scores were also linked to less GMV in regions related to response inhibition. Objective: Dieting is a popular method of weight control. However, few dieters are able to maintain initial weight losses over an extended period of time. Why do most restrained dieters fail to lose weight? Alterations in brain structures associated with restrained eating (RE) represent one potentially important mechanism that contributes to difficulties in maintaining weight loss within this group...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28394230/advanced-mri-techniques-biomarkers-in-neuropsychiatric-lupus
#11
N Sarbu, P Toledano, A Calvo, E Roura, M I Sarbu, G Espinosa, X Lladó, R Cervera, N Bargalló
Objectives The objective of this study was to determine whether advanced MRI could provide biomarkers for diagnosis and prognosis in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Our prospective study included 28 systemic lupus erythematosus (SLE) patients with primary central NPSLE, 22 patients without NPSLE and 20 healthy controls. We used visual scales to evaluate atrophy and white matter hyperintensities, voxel-based morphometry and Freesurfer to measure brain volume, plus diffusion-tensor imaging (DTI) to assess white matter (WM) and gray matter (GM) damage...
April 2017: Lupus
https://www.readbyqxmd.com/read/28392672/shape-analysis-with-hyperbolic-wasserstein-distance
#12
Jie Shi, Wen Zhang, Yalin Wang
Shape space is an active research field in computer vision study. The shape distance defined in a shape space may provide a simple and refined index to represent a unique shape. Wasserstein distance defines a Riemannian metric for the Wasserstein space. It intrinsically measures the similarities between shapes and is robust to image noise. Thus it has the potential for the 3D shape indexing and classification research. While the algorithms for computing Wasserstein distance have been extensively studied, most of them only work for genus-0 surfaces...
June 2016: Proceedings
https://www.readbyqxmd.com/read/28391034/the-structural-and-functional-correlates-of-the-efficiency-in-fearful-face-detection
#13
Yongchao Wang, Nana Guo, Li Zhao, Hui Huang, Xiaonan Yao, Na Sang, Xin Hou, Yu Mao, Taiyong Bi, Jiang Qiu
Human visual system is found to be much efficient in searching for a fearful face. Some individuals are more sensitive to this threat-related stimulus. However, we still know little about the neural correlates of such variability. In the current study, we exploited a visual search paradigm, and asked the subjects to search for a fearful face or a target gender. Every subject showed a shallower search function for fearful face search than face gender search, indicating a stable fearful face advantage. We then used voxel-based morphometry (VBM) analysis and correlated this advantage to the gray matter volume (GMV) of some presumably face related cortical areas...
April 5, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28390850/grey-matter-reduction-in-the-caudate-nucleus-in-patients-with-persistent-negative-symptoms-an-ale-meta-analysis
#14
REVIEW
Ying Li, Wen-Xiu Li, Dong-Jie Xie, Yi Wang, Eric F C Cheung, Raymond C K Chan
OBJECTIVES: In the present study, we used Activation Likelihood Estimation (ALE) meta-analysis to quantitatively examine brain grey matter reduction in schizophrenia patients with persistent negative symptoms (PNS). METHOD: A total of 12 voxel-based morphometry (VBM) studies were included in ALE meta-analysis using more stringent criterion of PNS. RESULTS: Significant grey matter reduction in the PNS group relative to controls was observed in the left caudate nucleus, the left precentral region, the left middle frontal region, the bilateral parahippocampal region, the left anterior cingulate region, the bilateral medial frontal gyrus, the thalamus and the insula...
April 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28390437/brain-structural-investigation-and-hippocampal-tractography-in-medication-overuse-headache-a-native-space-analysis
#15
M Meyer, G Di Scala, M Edde, B Dilharreguy, F Radat, M Allard, S Chanraud
BACKGROUND: Spatial normalization of brain images, a prerequisite for voxel based morphometry analysis, may account for the large variability of the volumetric data in medication overuse headache (MOH); possibly because this disease concerns patients differing on both sex and age, and hence with different brain size and shape. METHODS: The present study aimed at providing a subject-based analysis of macrostructure using a native space volumes segmentation (Freesurfer), and microstructure using a region of interest (ROI: i...
April 8, 2017: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/28387678/memory-is-not-enough-the-neurobiological-substrates-of-dynamic-cognitive-reserve
#16
Laura Serra, Michela Bruschini, Carlotta Di Domenico, Giulia Bechi Gabrielli, Camillo Marra, Carlo Caltagirone, Mara Cercignani, Marco Bozzali
Changes in the residual memory variance are considered as a dynamic aspect of cognitive reserve (d-CR). We aimed to investigate for the first time the neural substrate associated with changes in the residual memory variance overtime in patients with amnestic mild cognitive impairment (aMCI). Thirty-four aMCI patients followed-up for 36 months and 48 healthy elderly individuals (HE) were recruited. All participants underwent 3T MRI, collecting T1-weighted images for voxel-based morphometry (VBM). They underwent an extensive neuropsychological battery, including six episodic memory tests...
April 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28383208/olfactory-brain-gray-matter-volume-reduction-in-patients-with-chronic-rhinosinusitis
#17
Pengfei Han, Katherine L Whitcroft, Jessica Fischer, Johannes Gerber, Mandy Cuevas, Peter Andrews, Thomas Hummel
BACKGROUND: Chronic rhinosinusitis (CRS) is a common inflammatory condition and a major cause of olfactory loss. Olfactory dysfunction has been associated with reduced olfactory bulb (OB) volume and gray matter (GM) density in the olfactory-related brain areas. The aim of this study was to investigate brain GM structural and OB volume alterations in patients with CRS. METHODS: Structural brain images were collected from 21 CRS patients and 31 healthy controls on a 3-T scanner...
April 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28381986/simulating-longitudinal-brain-mris-with-known-volume-changes-and-realistic-variations-in-image-intensity
#18
Bishesh Khanal, Nicholas Ayache, Xavier Pennec
This paper presents a simulator tool that can simulate large databases of visually realistic longitudinal MRIs with known volume changes. The simulator is based on a previously proposed biophysical model of brain deformation due to atrophy in AD. In this work, we propose a novel way of reproducing realistic intensity variation in longitudinal brain MRIs, which is inspired by an approach used for the generation of synthetic cardiac sequence images. This approach combines a deformation field obtained from the biophysical model with a deformation field obtained by a non-rigid registration of two images...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28374074/abnormal-subcortical-nuclei-shapes-in-patients-with-type-2-diabetes-mellitus
#19
Ji Chen, Junxiang Zhang, Xuebing Liu, Xiaoyang Wang, Xiangjin Xu, Hui Li, Bo Cao, Yanqiu Yang, Jingjing Lu, Ziqian Chen
OBJECTIVES: Type 2 diabetes mellitus (T2DM) increases the risk of brain atrophy and dementia. We aimed to elucidate deep grey matter (GM) structural abnormalities and their relationships with T2DM cognitive deficits by combining region of interest (ROI)-based volumetry, voxel-based morphometry (VBM) and shape analysis. METHODS: We recruited 23 T2DM patients and 24 age-matched healthy controls to undergo T1-weighted structural MRI scanning. Images were analysed using the three aforementioned methods to obtain deep GM structural shapes and volumes...
April 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28373956/a-neural-network-underlying-intentional-emotional-facial-expression-in-neurodegenerative-disease
#20
Kelly A Gola, Tal Shany-Ur, Peter Pressman, Isa Sulman, Eduardo Galeana, Hillary Paulsen, Lauren Nguyen, Teresa Wu, Babu Adhimoolam, Pardis Poorzand, Bruce L Miller, Katherine P Rankin
Intentional facial expression of emotion is critical to healthy social interactions. Patients with neurodegenerative disease, particularly those with right temporal or prefrontal atrophy, show dramatic socioemotional impairment. This was an exploratory study examining the neural and behavioral correlates of intentional facial expression of emotion in neurodegenerative disease patients and healthy controls. One hundred and thirty three participants (45 Alzheimer's disease, 16 behavioral variant frontotemporal dementia, 8 non-fluent primary progressive aphasia, 10 progressive supranuclear palsy, 11 right-temporal frontotemporal dementia, 9 semantic variant primary progressive aphasia patients and 34 healthy controls) were video recorded while imitating static images of emotional faces and producing emotional expressions based on verbal command; the accuracy of their expression was rated by blinded raters...
2017: NeuroImage: Clinical
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