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Brain Morphometry

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https://www.readbyqxmd.com/read/28639048/evaluating-anorexia-related-brain-atrophy-using-mp2rage-based-morphometry
#1
José Boto, Georgios Gkinis, Alexis Roche, Tobias Kober, Bénédicte Maréchal, Nadia Ortiz, Karl-Olof Lövblad, François Lazeyras, Maria Isabel Vargas
AIM: To evaluate brain atrophy in anorexic patients by automated cerebral segmentation with the magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) MRI sequence. MATERIAL AND METHODS: Twenty patients (female; mean age, 27.9 years), presenting consecutively for brain MRI between August 2014-December 2016 with clinical suspicion of anorexia nervosa and BMI<18.5 kg/m(2) were included. Controls were ten healthy females (mean age, 26.5 years). Automated brain morphometry was performed based on MP2RAGE...
June 21, 2017: European Radiology
https://www.readbyqxmd.com/read/28638712/frontal-assessment-battery-and-frontal-atrophy-in-amyotrophic-lateral-sclerosis
#2
Tatsuhiro Terada, Jun Miyata, Tomokazu Obi, Manabu Kubota, Miho Yoshizumi, Kinya Yamazaki, Kouichi Mizoguchi, Toshiya Murai
OBJECTIVES: To determine the potential utility of the frontal assessment battery (FAB) in assessing cognitive impairments in amyotrophic lateral sclerosis (ALS), we investigated the association between the FAB score and regional gray matter volume, and ascertained whether the regional brain alterations related to cognitive impairments occur in relatively mild stage of ALS. MATERIALS AND METHODS: Twenty-four ALS patients with a Mini-Mental State Examination score of >23, a normal score on the Self-Rating Depression Scale, little or no disturbance in speech and handling utensils on the ALS Functional Rating Scale (ALSFRS), and normal measures on respiratory tests (respiratory function test and arterial blood gas analysis), and two age-matched normal control groups (one for FAB assessment and the other for brain morphometry) underwent FAB testing and structural magnetic resonance imaging...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28638338/physical-exercise-with-music-reduces-gray-and-white-matter-loss-in-the-frontal-cortex-of-elderly-people-the-mihama-kiho-scan-project
#3
Ken-Ichi Tabei, Masayuki Satoh, Jun-Ichi Ogawa, Tomoko Tokita, Noriko Nakaguchi, Koji Nakao, Hirotaka Kida, Hidekazu Tomimoto
Findings from previous studies suggest that physical exercise combined with cognitive training produces more positive effects on cognitive function in elderly people than physical exercise alone. However, the brain plasticity associated with these proposed benefits of combined therapy has not yet been investigated in elderly subjects. We hypothesized that the dual task group would experience greater benefits than the physical exercise alone and non-exercise control groups with regard to both cognitive function and brain plasticity...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28638109/voxel-based-morphometric-brain-comparison-between-healthy-subjects-and-major-depressive-disorder-patients-in-japanese-with-the-s-s-genotype-of-5-httlpr
#4
Natsuki Igata, Shingo Kakeda, Keita Watanabe, Satoru Ide, Taro Kishi, Osamu Abe, Ryouhei Igata, Asuka Katsuki, Nakao Iwata, Reiji Yoshimura, Yukunori Korogi
Individuals with s/s genotype of serotonin transporter gene-linked promotor region (5-HTTLPR), which appear with a high frequency in Japanese, exhibit more diagnosable depression in relation to stressful life events than those with the s/l or l/l genotype. We prospectively investigated the brain volume changes in first-episode and medication naïve major depression disorder patients (MDD) with the s/s genotype in Japanese. We assessed the differences between 27 MDD with the s/s genotype and 44 healthy subjects (HS) with the same genotype using a whole-brain voxel-by-voxel statistical analysis of MRI...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633986/gray-matter-abnormalities-in-non-comorbid-medication-naive-patients-with-major-depressive-disorder-or-social-anxiety-disorder
#5
Youjin Zhao, Lizhou Chen, Wenjing Zhang, Yuan Xiao, Chandan Shah, Hongru Zhu, Minlan Yuan, Huaiqiang Sun, Qiang Yue, Zhiyun Jia, Wei Zhang, Weihong Kuang, Qiyong Gong, Su Lui
BACKGROUND: An overlap of clinical symptoms between major depressive disorder (MDD) and social anxiety disorder (SAD) suggests that the two disorders exhibit similar brain mechanisms. However, few studies have directly compared the brain structures of the two disorders. The aim of this study was to assess the gray matter volume (GMV) and cortical thickness alterations between non-comorbid medication-naive MDD patients and SAD patients. METHODS: High-resolution T1-weighted images were acquired from 37 non-comorbid MDD patients, 24 non-comorbid SAD patients and 41 healthy controls (HCs)...
June 15, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28627088/astrogliosis-and-impaired-aquaporin-4-and-dystrophin-systems-in-idiopathic-normal-pressure-hydrocephalus
#6
Per Kristian Eide, Hans-Arne Hansson
AIMS: Idiopathic normal pressure hydrocephalus (iNPH) is one subtype of dementia that may improve following drainage of cerebrospinal fluid (CSF). This prospective observational study explored whether expression of the water channel aquaporin-4 (AQP4) and the anchoring molecule dystrophin 71 (Dp71) are altered at astrocytic perivascular endfeet and in adjacent neuropil of iNPH patient. Observations were related to measurements of pulsatile and static intracranial pressure (ICP). METHODS: The study included iNPH patients undergoing overnight monitoring of the pulsatile/static ICP, in whom a biopsy was taken from the frontal cerebral cortex during placement of the ICP sensor...
June 19, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28626050/admission-brain-cortical-volume-an-independent-determinant-of-poststroke-cognitive-vulnerability
#7
Sharmila Sagnier, Gwenaëlle Catheline, Bixente Dilharreguy, Fanny Munsch, Antoine Bigourdan, Mathilde Poli, Sabrina Debruxelles, Stéphane Olindo, Pauline Renou, François Rouanet, Vincent Dousset, Thomas Tourdias, Igor Sibon
BACKGROUND AND PURPOSE: Several markers of poststroke cognitive impairment have been reported. The role of brain cortical volume remains uncertain. The aim of this study was to evaluate the influence of brain cortical volume on cognitive outcomes using a voxel-based morphometry approach in subjects without prestroke dementia. METHODS: Ischemic stroke patients were prospectively recruited 24 to 72 hours post-stroke (M0). Cognition was evaluated at M0, 3 months, and 1 year (M12) using the Montreal Cognitive Assessment, the Isaacs set test, and the Zazzo's cancellation task...
June 16, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28622625/cigarette-smoking-is-associated-with-amplified-age-related-volume-loss-in-subcortical-brain-regions
#8
Timothy C Durazzo, Dieter J Meyerhoff, Karmen K Yoder, Donna E Murray
BACKGROUND: Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers...
June 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28614607/anatomical-and-functional-implications-of-crh-neurons-in-a-septal-nucleus-of-the-avian-brain-an-emphasis-on-glial-neuronal-interaction-via-v1a-receptors-in-vitro
#9
Gurueswar Nagarajan, Alexander Jurkevich, Seong W Kang, Wayne J Kuenzel
Previously, we showed that corticotropin releasing hormone immunoreactive (CRH-ir) neurons in a septal structure are associated with stress and the hypothalamo-pituitary-adrenal axis in birds. In this study, we focused upon CRH-ir neurons located within the septal structure called the nucleus of the hippocampal commissure (NHpC). Immunocytochemical and gene expression analyses were used to identify the anatomical and functional characteristics of cells within the NHpC. A comparative morphometry analysis showed that CRH-ir neurons in the NHpC were significantly larger than CRH-ir parvocellular neurons in the paraventricular nucleus of the hypothalamus (PVN) and lateral bed nucleus of the stria terminalis...
June 14, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28608653/complementary-cortical-gray-and-white-matter-developmental-patterns-in-healthy-preterm-neonates
#10
Vidya Rajagopalan, Julia A Scott, Mengyuan Liu, Kenneth Poskitt, Vann Chau, Steven Miller, Colin Studholme
Preterm birth is associated with brain injury and altered cognitive development. However, the consequences of extrauterine development are not clearly distinguished from perinatal brain injury. Therefore, we characterized cortical growth patterns from 30 to 46 postmenstrual weeks (PMW) in 27 preterm neonates (25-32 PMW at birth) without detectable brain injury on magnetic resonance imaging. We introduce surface-based morphometric descriptors that quantify radial (thickness) and tangential (area) change rates...
June 13, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28608601/brain-structural-properties-predict-psychologically-mediated-hypoalgesia-in-an-8-week-sham-acupuncture-treatment-for-migraine
#11
Jixin Liu, Junya Mu, Qianqian Liu, Wanghuan Dun, Ming Zhang, Jie Tian
Neuroimaging studies described brain structural changes that comprise the mechanisms underlying individual differences in migraine development and maintenance. However, whether such interindividual variability in migraine was observed in a pretreatment scan is a predisposition for subsequent hypoalgesia to placebo treatment that remains largely unclear. Using T1-weighted imaging, we investigated this issue in 50 healthy controls (HC) and 196 patients with migraine without aura (MO). An 8-week double-blinded, randomized, placebo-controlled acupuncture was used, and we only focused on the data from the sham acupuncture group...
June 13, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28606629/neural-substrates-underlying-balanced-time-perspective-a-combined-voxel-based-morphometry-and-resting-state-functional-connectivity-study
#12
Yiqun Guo, Zhiyi Chen, Tingyong Feng
Balanced time perspective (BTP), which is defined as a mental ability to switch flexibly among different time perspectives Zimbardo and Boyd (1999), has been suggested to be a central component of positive psychology Boniwell and Zimbardo (2004). BTP reflects individual's cognitive flexibility towards different time frames, which leads to many positive outcomes, including positive mood, subjective wellbeing, emotional intelligence, fluid intelligence, and executive control. However, the neural basis of BTP is still unclear...
June 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28594150/cortical-thickness-is-not-associated-with-current-depression-in-a-clinical-treatment-study
#13
Greg Perlman, Elizabeth Bartlett, Christine DeLorenzo, Myrna Weissman, Patrick McGrath, Todd Ogden, Tony Jin, Phillip Adams, Madhukar Trivedi, Benji Kurian, Maria Oquendo, Melvin McInnis, Sarah Weyandt, Maurizio Fava, Crystal Cooper, Ashley Malchow, Ramin Parsey
BACKGROUND: Reduced cortical thickness is a candidate biological marker of depression, although findings are inconsistent. This could reflect analytic heterogeneity, such as use of region-wise cortical thickness based on the Freesurfer Desikan-Killiany (DK) atlas or surface-based morphometry (SBM). The Freesurfer Destrieux (DS) atlas (more, smaller regions) has not been utilized in depression studies. This could also reflect differential gender and age effects. METHODS: Cortical thickness was collected from 170 currently depressed adults and 52 never-depressed adults...
June 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28593048/neural-correlates-of-ataxia-severity-in-spinocerebellar-ataxia-type-3-machado-joseph-disease
#14
Carlos R Hernandez-Castillo, Rosalinda Diaz, Aurelio Campos-Romo, Juan Fernandez-Ruiz
BACKGROUND: Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant inherited neurodegenerative disorder. Several post-mortem and imaging studies have shown cerebellar and brainstem atrophy. A number of studies have used volumetric regional information to investigate the relationship between neurodegeneration and the ataxia severity. However, regional analysis can obscure the specific location in which the degenerative process is affecting the brain tissue, which can be crucial for the development of new target treatments for this disease...
2017: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/28588477/associations-between-mobility-cognition-and-brain-structure-in-healthy-older-adults
#15
Naiara Demnitz, Enikő Zsoldos, Abda Mahmood, Clare E Mackay, Mika Kivimäki, Archana Singh-Manoux, Helen Dawes, Heidi Johansen-Berg, Klaus P Ebmeier, Claire E Sexton
Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0 ± 5.1 years), we tested the relationship between mobility measures, cognitive assessments, and MRI markers of brain structure. Mobility was assessed in 2007-2009, using gait, balance and chair-stands tests. In 2012-2015, cognitive testing assessed executive function, memory and processing-speed; gray matter volumes (GMV) were examined using voxel-based morphometry, and white matter microstructure was assessed using tract-based spatial statistics of fractional anisotropy, axial diffusivity (AD), and radial diffusivity (RD)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28588470/examining-brain-morphometry-associated-with-self-esteem-in-young-adults-using-multilevel-roi-features-based-classification-method
#16
Bo Peng, Jieru Lu, Aditya Saxena, Zhiyong Zhou, Tao Zhang, Suhong Wang, Yakang Dai
Purpose: This study is to exam self-esteem related brain morphometry on brain magnetic resonance (MR) images using multilevel-features-based classification method. Method: The multilevel region of interest (ROI) features consist of two types of features: (i) ROI features, which include gray matter volume, white matter volume, cerebrospinal fluid volume, cortical thickness, and cortical surface area, and (ii) similarity features, which are based on similarity calculation of cortical thickness between ROIs. For each feature type, a hybrid feature selection method, comprising of filter-based and wrapper-based algorithms, is used to select the most discriminating features...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28584917/morphometry-and-microsurgical-anatomy-of-bochdalek-s-flower-basket-and-the-related-structures-of-the-cerebellopontine-angle
#17
Laszlo Barany, Gabor Baksa, Lajos Patonay, Oliver Ganslandt, Michael Buchfelder, Peter Kurucz
BACKGROUND: Bochdalek's flower basket (Bfb) is the distal part of the horizontal segment of the fourth ventricle's choroid plexus protruding through the lateral aperture (foramen of Luschka). The microsurgical anatomy of the cerebellopontine angle, fourth ventricle and its inner choroid plexus is well described in the literature, but only one radiological study has investigated the Bfb so far. The goal of the present study was to give an extensive morphometric analysis of the Bfb for the first time and discuss the surgically relevant anatomical aspects...
June 6, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28580295/regional-brain-network-organization-distinguishes-the-combined-and-inattentive-subtypes-of-attention-deficit-hyperactivity-disorder
#18
Jacqueline F Saad, Kristi R Griffiths, Michael R Kohn, Simon Clarke, Leanne M Williams, Mayuresh S Korgaonkar
Attention Deficit Hyperactivity Disorder (ADHD) is characterized clinically by hyperactive/impulsive and/or inattentive symptoms which determine diagnostic subtypes as Predominantly Hyperactive-Impulsive (ADHD-HI), Predominantly Inattentive (ADHD-I), and Combined (ADHD-C). Neuroanatomically though we do not yet know if these clinical subtypes reflect distinct aberrations in underlying brain organization. We imaged 34 ADHD participants defined using DSM-IV criteria as ADHD-I (n = 16) or as ADHD-C (n = 18) and 28 matched typically developing controls, aged 8-17 years, using high-resolution T1 MRI...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28562484/sex-differences-in-the-association-between-gray-matter-volume-and-verbal-creativity
#19
Baoguo Shi, Li Xu, Qunlin Chen, Jiang Qiu
The explanation for why significant sex differences are found in creativity has become an increasingly important topic. The current study applied a cognitive neuroscience perspective and voxel-based morphometry to investigate the sex differences for the association between verbal creativity and gray matter volume (GMV) in a large sample of healthy adults from the Chinese Mainland (163 men and 193 women). Furthermore, we sought to determine which brain regions are responsible for these differences. Our behavioral results showed a significant sex difference...
May 30, 2017: Neuroreport
https://www.readbyqxmd.com/read/28560155/grey-matter-abnormalities-in-children-and-adolescents-with-functional-neurological-symptom-disorder
#20
Kasia Kozlowska, Kristi R Griffiths, Sheryl L Foster, James Linton, Leanne M Williams, Mayuresh S Korgaonkar
OBJECTIVE: Functional neurological symptom disorder refers to the presence of neurological symptoms not explained by neurological disease. Although this disorder is presumed to reflect abnormal function of the brain, recent studies in adults show neuroanatomical abnormalities in brain structure. These structural brain abnormalities have been presumed to reflect long-term adaptations to the disorder, and it is unknown whether child and adolescent patients, with illness that is typically of shorter duration, show similar deficits or have normal brain structure...
2017: NeuroImage: Clinical
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