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https://www.readbyqxmd.com/read/28633567/endogenous-bioelectric-signaling-networks-exploiting-voltage-gradients-for-control-of-growth-and-form
#1
Michael Levin, Giovanni Pezzulo, Joshua M Finkelstein
Living systems exhibit remarkable abilities to self-assemble, regenerate, and remodel complex shapes. How cellular networks construct and repair specific anatomical outcomes is an open question at the heart of the next-generation science of bioengineering. Developmental bioelectricity is an exciting emerging discipline that exploits endogenous bioelectric signaling among many cell types to regulate pattern formation. We provide a brief overview of this field, review recent data in which bioelectricity is used to control patterning in a range of model systems, and describe the molecular tools being used to probe the role of bioelectrics in the dynamic control of complex anatomy...
June 21, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28633035/economy-and-endurance-in-human-evolution
#2
REVIEW
Herman Pontzer
The evolutionary pressures shaping humans' unique bipedal locomotion have been a focus of research since Darwin, but the origins of humans' economical walking gait and endurance running capabilities remain unclear. Here, I review the anatomical and physiological determinants of locomotor economy (e.g., limb length and posture) and endurance (e.g., muscle volume and fiber type) and investigate their development in the hominin fossil record. The earliest hominins were bipedal but retained ape-like features in the hind limb that would have limited their walking economy compared to living humans...
June 19, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28631949/diffusion-tensor-imaging-tensor-shape-analysis-for-assessment-of-regional-white-matter-differences
#3
Dana M Middleton, Jonathan Y Li, Hui J Lee, Steven Chen, Patricia I Dickson, N Matthew Ellinwood, Leonard E White, James M Provenzale
Purpose The purpose of this study was to investigate a novel tensor shape plot analysis technique of diffusion tensor imaging data as a means to assess microstructural differences in brain tissue. We hypothesized that this technique could distinguish white matter regions with different microstructural compositions. Methods Three normal canines were euthanized at seven weeks old. Their brains were imaged using identical diffusion tensor imaging protocols on a 7T small-animal magnetic resonance imaging system...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28630252/alpha-band-brain-oscillations-shape-the-processing-of-perceptible-as-well-as-imperceptible-somatosensory-stimuli-during-selective-attention
#4
Norman Forschack, Till Nierhaus, Matthias M Müller, Arno Villringer
Attention filters and weights sensory information according to behavioral demands. Stimulus-related neural responses are increased for the attended stimulus. Does alpha-band activity mediate this effect and is it restricted to conscious sensory events (suprathreshold), or does it also extend to unconscious stimuli (subthreshold)? To address these questions, we recorded EEG in healthy male and female volunteers undergoing subthreshold and suprathreshold somatosensory electrical stimulation to the left or right index finger...
June 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28629989/patient-proxy-agreement-on-the-health-related-quality-of-life-one-year-after-traumatic-brain-injury
#5
Hei-Fen Hwang, Chih-Yi Chen, Mau-Roung Lin
OBJECTIVE: To examine the level of agreement between patients and their proxies on a measure of health-related quality of life (HRQL) 1 year after traumatic brain injury (TBI). DESIGN: A cross-sectional study. PARTICIPANTS: and Setting: Eighty-eighty patients with TBI identified from discharge records of four hospitals in Taiwan and 88 family members or friends who could answer questions regarding the patient's health and HRQL 1 year after the injury...
June 16, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28626884/empirical-tests-of-a-brain-based-model-of-executive-function-development
#6
Sammy Perone, Daniel J Plebanek, Megan G Lorenz, John P Spencer, Larissa K Samuelson
Executive function (EF) plays a foundational role in development. A brain-based model of EF development is probed for the experiences that strengthen EF in the dimensional change card sort task in which children sort cards by one rule and then are asked to switch to another. Three-year-olds perseverate on the first rule, failing the task, whereas 4-year-olds pass. Three predictions of the model are tested to help 3-year-olds (N = 54) pass. Experiment 1 shows that experience with shapes and the label "shape" helps children...
June 19, 2017: Child Development
https://www.readbyqxmd.com/read/28626291/machine-learning-in-a-graph-framework-for-subcortical-segmentation
#7
Zhihui Guo, Satyananda Kashyap, Milan Sonka, Ipek Oguz
Automated and reliable segmentation of subcortical structures from human brain magnetic resonance images is of great importance for volumetric and shape analyses in quantitative neuroimaging studies. However, poor boundary contrast and variable shape of these structures make the automated segmentation a tough task. We propose a 3D graph-based machine learning method, called LOGISMOS-RF, to segment the caudate and the putamen from brain MRI scans in a robust and accurate way. An atlas-based tissue classification and bias-field correction method is applied to the images to generate an initial segmentation for each structure...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28625504/mutations-in-armc9-which-encodes-a-basal-body-protein-cause-joubert-syndrome-in-humans-and-ciliopathy-phenotypes-in-zebrafish
#8
Julie C Van De Weghe, Tamara D S Rusterholz, Brooke Latour, Megan E Grout, Kimberly A Aldinger, Ranad Shaheen, Jennifer C Dempsey, Sateesh Maddirevula, Yong-Han H Cheng, Ian G Phelps, Matthias Gesemann, Himanshu Goel, Ohad S Birk, Talal Alanzi, Rifaat Rawashdeh, Arif O Khan, Michael J Bamshad, Deborah A Nickerson, Stephan C F Neuhauss, William B Dobyns, Fowzan S Alkuraya, Ronald Roepman, Ruxandra Bachmann-Gagescu, Dan Doherty
Joubert syndrome (JS) is a recessive neurodevelopmental disorder characterized by hypotonia, ataxia, abnormal eye movements, and variable cognitive impairment. It is defined by a distinctive brain malformation known as the "molar tooth sign" on axial MRI. Subsets of affected individuals have malformations such as coloboma, polydactyly, and encephalocele, as well as progressive retinal dystrophy, fibrocystic kidney disease, and liver fibrosis. More than 35 genes have been associated with JS, but in a subset of families the genetic cause remains unknown...
June 14, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28623672/craniosynostosis-recognition-clinical-characteristics-and-treatment
#9
REVIEW
Nina Kajdic, Peter Spazzapan, Tomaz Velnar
Craniosynostosis is a developmental craniofacial anomaly, resulting in impairment of brain development and abnormally shaped skull. The main cause of craniosynostosis is premature closure of one or more cranial sutures. It usually occurs as an isolated condition, but may also be associated with other malformations as part of complex syndromes. When left untreated, craniosynostosis can cause serious complications, such as developmental delay, facial abnormality, sensory, respiratory and neurological dysfunction, anomalies affecting the eye, and psychological disturbances...
June 17, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28623006/a-longevity-study-with-enhancer-substances-selegiline-bpap-detected-an-unknown-tumor-manifestation-suppressing-regulation-in-rat-brain
#10
J Knoll, K Baghy, S Eckhardt, P Ferdinandy, M Garami, L G Harsing, P Hauser, Z Mervai, T Pocza, Z Schaff, D Schuler, I Miklya
AIMS: First proof to show that (-)-deprenyl/selegiline (DEP), the first selective inhibitor of MAO-B, later identified as the first β-phenylethylamine (PEA)-derived synthetic catecholaminergic activity enhancer (CAE) substance and (2R)-1-(1-benzofuran-2-yl)-N-propylpentane-2-amine (BPAP), the tryptamine-derived presently known most potent, selective, synthetic enhancer substance, are specific markers of unknown enhancer-sensitive brain regulations. MAIN METHODS: Longevity study disclosing the operation of tumor-manifestation-suppressing (TMS) regulation in rat brain...
June 13, 2017: Life Sciences
https://www.readbyqxmd.com/read/28622174/insufficient-astrocyte-derived-brain-derived-neurotrophic-factor-contributes-to-propofol-induced-neuron-death-through-akt-glycogen-synthase-kinase-3%C3%AE-mitochondrial-fission-pathway
#11
Yanan Liu, Yasheng Yan, Yasuyoshi Inagaki, Sarah Logan, Zeljko J Bosnjak, Xiaowen Bai
BACKGROUND: Growing animal evidence demonstrates that prolonged exposure to propofol during brain development induces widespread neuronal cell death, but there is little information on the role of astrocytes. Astrocytes can release neurotrophic growth factors such as brain-derived neurotrophic factor (BDNF), which can exert the protective effect on neurons in paracrine fashion. We hypothesize that during propofol anesthesia, BDNF released from developing astrocytes may not be sufficient to prevent propofol-induced neurotoxicity...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28621462/evidence-for-convergent-evolution-of-a-neocortex-like-structure-in-a-late-permian-therapsid
#12
Michael Laaß, Anders Kaestner
The special sensory, motor, and cognitive capabilities of mammals mainly depend upon the neocortex, which is the six-layered cover of the mammalian forebrain. The origin of the neocortex is still controversial and the current view is that larger brains with neocortex first evolved in late Triassic Mammaliaformes. Here, we report the earliest evidence of a structure analogous to the mammalian neocortex in a forerunner of mammals, the fossorial anomodont Kawingasaurus fossilis from the late Permian of Tanzania...
June 16, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28620254/isolation-morphological-identification-and-in-vitro-antibacterial-activity-of-endophytic-bacteria-isolated-from-azadirachta-indica-neem-leaves
#13
Ankit Kumar Singh, Rajesh Kumar Sharma, Varsha Sharma, Tanmay Singh, Rajesh Kumar, Dimple Kumari
AIM: The objective of this study was to isolate endophytic bacteria from Azadirachta indica (neem) leaves, their identification and investigate their antibacterial activity against three Gram-positive bacteria, Staphylococcus aureus, Streptococcus pyogenes and Bacillus cereus and Gram-negative bacteria Escherichia coli, Salmonella Typhimurium and Klebsiella pneumoniae. MATERIALS AND METHODS: Fresh leaves of A. indica (neem) was procured from the Department of Botany, JNKVV, Jabalpur...
May 2017: Veterinary World
https://www.readbyqxmd.com/read/28620181/hair-bundles-of-cochlear-outer-hair-cells-are-shaped-to-minimize-their-fluid-dynamic-resistance
#14
Nikola Ciganović, Amanuel Wolde-Kidan, Tobias Reichenbach
The mammalian sense of hearing relies on two types of sensory cells: inner hair cells transmit the auditory stimulus to the brain, while outer hair cells mechanically modulate the stimulus through active feedback. Stimulation of a hair cell is mediated by displacements of its mechanosensitive hair bundle which protrudes from the apical surface of the cell into a narrow fluid-filled space between reticular lamina and tectorial membrane. While hair bundles of inner hair cells are of linear shape, those of outer hair cells exhibit a distinctive V-shape...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619178/changes-in-subcortical-shape-and-cognitive-function-in-patients-with-chronic-insomnia
#15
Dae Lim Koo, Jeong-Hyeon Shin, Jae-Sung Lim, Joon-Kyung Seong, Eun Yeon Joo
OBJECTIVE: The aim of this study was to examine morphological changes in subcortical structures via surface-based analysis and to correlate local shape changes with cognitive function. METHODS: We analyzed subcortical brain morphology and compared the shape changes with clinical and neuropsychological features in patients with chronic insomnia. RESULTS: Hippocampal atrophy was associated with higher Pittsburgh Sleep Quality Index scores (r = -0...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28617656/sarcocystis-pantherophis-n-sp-from-eastern-rat-snakes-pantherophis-alleghaniensis-definitive-hosts-and-interferon-gamma-gene-knockout-mice-as-experimental-intermediate-hosts
#16
Shiv Verma, David Lindsay, Joseph Mowery, Benjamin Rosenthal, J P Dubey
Here we report a new species, Sarcocystis pantherophisi n. sp. with the Eastern rat snake (Pantherophis alleghaniensis) as natural definitive host and the interferon gamma gene knockout (KO) mouse as the experimental intermediate host. Sporocysts (n = 15) from intestinal contents of the snake were 17.3 x 10.9 µm. Sporocysts were orally infective to interferon gamma KO mice but not to laboratory raised albino outbred house mice (Mus musculus). The interferon gamma KO mice developed schizont-associated neurological signs and schizonts were cultivated in vitro from the brain...
June 15, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28617224/enigma-viewer-interactive-visualization-strategies-for-conveying-effect-sizes-in-meta-analysis
#17
Guohao Zhang, Peter Kochunov, Elliot Hong, Sinead Kelly, Christopher Whelan, Neda Jahanshad, Paul Thompson, Jian Chen
BACKGROUND: Global scale brain research collaborations such as the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) consortium are beginning to collect data in large quantity and to conduct meta-analyses using uniformed protocols. It becomes strategically important that the results can be communicated among brain scientists effectively. Traditional graphs and charts failed to convey the complex shapes of brain structures which are essential to the understanding of the result statistics from the analyses...
June 6, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28617091/fragment-based-virtual-screening-approach-and-molecular-dynamics-simulation-studies-for-identification-of-bace1-inhibitor-leads
#18
Prabu Manoharan, Nanda Ghoshal
Traditional structure-based virtual screening method to identify drug-like small molecules for BACE1 is so far unsuccessful. Location of BACE1, poor Blood Brain Barrier permeability and P-glycoprotein (Pgp) susceptibility of the inhibitors make it even more difficult. Fragment-based drug design method is suitable for efficient optimization of initial hit molecules for target like BACE1. We have developed a fragment-based virtual screening approach to identify/optimize the fragment molecules as a starting point...
June 15, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28615831/species-diversity-of-the-genus-thelohanellus-kudo-1933-myxozoa-bivalvulida-parasitizing-fishes-in-indian-subcontinent
#19
REVIEW
Harpreet Kaur, Ranjeet Singh, Anu Katoch, Rajni Attri, Shoaib Ali Dar, Aditya Gupta
A synopsis of 52 nominal species of the genus Thelohanellus Kudo, 1933 reported to infect freshwater fishes in India is presented. These species infect various organs such as gills, fins, scales, skin, muscles, gall bladder, kidney etc. The diagnostic features of the genus include tear-shaped myxospores with smooth shell valves and single polar capsule. The members are histozoic in their nature of parasitism infecting fresh water fishes. The present manuscript is aimed to compile the list of reported species in India along with essential information on morphometrics of vegetative stage, host, organ preference and pathogenic effects if any...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28612935/early-adversity-and-brain-response-to-faces-in-young-adulthood
#20
Johannes Lieslehto, Vesa Kiviniemi, Pirjo Mäki, Jenni Koivukangas, Tanja Nordström, Jouko Miettunen, Jennifer H Barnett, Peter B Jones, Graham K Murray, Irma Moilanen, Tomáš Paus, Juha Veijola
Early stressors play a key role in shaping interindividual differences in vulnerability to various psychopathologies, which according to the diathesis-stress model might relate to the elevated glucocorticoid secretion and impaired responsiveness to stress. Furthermore, previous studies have shown that individuals exposed to early adversity have deficits in emotion processing from faces. This study aims to explore whether early adversities associate with brain response to faces and whether this association might associate with the regional variations in mRNA expression of the glucocorticoid receptor gene (NR3C1)...
June 14, 2017: Human Brain Mapping
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