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Hippocampus morphometry

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https://www.readbyqxmd.com/read/29128164/grey-matter-volume-loss-is-associated-with-specific-clinical-motor-signs-in-huntington-s-disease
#1
Emma M Coppen, Milou Jacobs, Annette A van den Berg-Huysmans, Jeroen van der Grond, Raymund A C Roos
BACKGROUND: Motor disturbances are clinical hallmarks of Huntington's disease (HD) and involve chorea, dystonia, hypokinesia and visuomotor dysfunction. Investigating the association between specific motor signs and different regional volumes is important to understand the heterogeneity of HD. OBJECTIVE: To investigate the motor phenotype of HD and associations with subcortical and cortical grey matter volume loss. METHODS: Structural T1-weighted MRI scans of 79 HD patients and 30 healthy controls were used to calculate volumes of seven subcortical structures including the nucleus accumbens, hippocampus, thalamus, caudate nucleus, putamen, pallidum and amygdala...
November 2, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29067330/differential-medial-temporal-lobe-morphometric-predictors-of-item-and-relational-encoded-memories-in-healthy-individuals-and-in-individuals-with-mild-cognitive-impairment-and-alzheimer-s-disease
#2
Jesus J Gomar, J Daniel Ragland, Aziz M Uluğ, Amber Sousa, Edward D Huey, Concepcion Conejero-Goldberg, Peter Davies, Terry E Goldberg
INTRODUCTION: Episodic memory processes are supported by different subregions of the medial temporal lobe (MTL). In contrast to a unitary model of memory recognition supported solely by the hippocampus, a current model suggests that item encoding engages perirhinal cortex, whereas relational encoding engages parahippocampal cortex and the hippocampus. However, this model has not been examined in the context of aging, neurodegeneration, and MTL morphometrics. METHODS: Forty-four healthy subjects (HSs) and 18 cognitively impaired subjects (nine mild cognitive impairment [MCI] and nine Alzheimer's disease [AD] patients) were assessed with the relational and item-specific encoding task (RISE) and underwent 3T magnetic resonance imaging...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29058349/the-bumps-under-the-hippocampus
#3
Cheng Chang, Chuan Huang, Naiyun Zhou, Shawn Xiang Li, Lawrence Ver Hoef, Yi Gao
Shown in every neuroanatomy textbook, a key morphological feature is the bumpy ridges, which we refer to as hippocampal dentation, on the inferior aspect of the hippocampus. Like the folding of the cerebral cortex, hippocampal dentation allows for greater surface area in a confined space. However, examining numerous approaches to hippocampal segmentation and morphology analysis, virtually all published 3D renderings of the hippocampus show the inferior surface to be quite smooth or mildly irregular; we have rarely seen the characteristic bumpy structure on reconstructed 3D surfaces...
October 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29038494/a-study-of-the-brain-abnormalities-of-post-stroke-depression-in-frontal-lobe-lesion
#4
Yu Shi, Yanyan Zeng, Lei Wu, Wei Liu, Ziping Liu, Shanshan Zhang, Jianming Yang, Wen Wu
Post stroke depression (PSD) is a serious complication of stroke. Brain imaging is an important method of studying the mechanism of PSD. However, few studies have focused on the single lesion location. The aim of this study was to investigate the brain mechanism of frontal lobe PSD using combined voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI). In total, 30 first-time ischemic frontal lobe stroke patients underwent T1 weighted MRI and resting-state fMRI scans. Clinical assessments included the 24-item Hamilton Rating Scale for Depression, the National Institutes of Health Stroke Scale, and the Mini-Mental State Examination...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923275/in-vivo-magnetic-resonance-images-reveal-neuroanatomical-sex-differences-through-the-application-of-voxel-based-morphometry-in-c57bl-6-mice
#5
Cassandra E Meyer, Florian Kurth, Stefano Lepore, Josephine L Gao, Hadley Johnsonbaugh, Mandavi R Oberoi, Stephen J Sawiak, Allan MacKenzie-Graham
Behaviorally relevant sex differences are often associated with structural differences in the brain and many diseases are sexually dimorphic in prevalence and progression. Characterizing sex differences is imperative to gaining a complete understanding of behavior and disease which will, in turn, allow for a balanced approach to scientific research and the development of therapies. In this study, we generated novel tissue probability maps (TPMs) based on 30 male and 30 female in vivo C57BL/6 mouse brain magnetic resonance images and used voxel-based morphometry (VBM) to analyze sex differences...
September 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28919059/rates-of-hippocampal-atrophy-and-presence-of-post-mortem-tdp-43-in-patients-with-alzheimer-s-disease-a-longitudinal-retrospective-study
#6
Keith A Josephs, Dennis W Dickson, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Leonard Petrucelli, Amanda M Liesinger, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Joseph E Parisi, Ronald C Petersen, Clifford R Jack, Jennifer L Whitwell
BACKGROUND: Post-mortem studies have not identified an association between β-amyloid or tau and rates of hippocampal atrophy in patients with Alzheimer's disease. TAR DNA binding protein 43 (TDP-43) is another protein linked to Alzheimer's disease. We aimed to investigate whether hippocampal TDP-43 is associated with increased rates of hippocampal atrophy. METHODS: In this longitudinal retrospective study, we analysed post-mortem brain tissue of all individuals with an Alzheimer's disease spectrum pathological diagnosis who had antemortem head MRI scans between Jan 1, 1999, and Dec 31, 2012, and who had been recruited into the Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic Alzheimer's Disease Patient Registry, or the Mayo Clinic Study of Aging...
November 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28899759/hippocampal-metabolism-and-prefrontal-brain-structure-a-combined-1h-mr-spectroscopy-neuropsychological-and-voxel-based-morphometry-vbm-study
#7
Johanna Steinke, Christian Gaser, Kerstin Langbein, Maren Dietzek, Alexander Gussew, Jürgen R Reichenbach, Stefan Smesny, Heinrich Sauer, Igor Nenadić
Hippocampal structural and functional integrity impacts on multiple remote areas of the brain, and this connectivity is central to multiple cognitive functions in healthy and disease. We studied associations of hippocampal metabolic markers N-acetyl aspartate (NAA) and glutamate (Glu and Glx; assessed with 1H magnetic resonance spectroscopy) and brain grey matter (studied with voxel-based morphometry, VBM) in 20 healthy subjects. We found a significant correlation between right hippocampal NAA and left ventrolateral prefrontal cortical grey matter (TFCE, p<0...
December 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28888350/anterior-cingulate-cortex-grey-matter-volume-abnormalities-in-adolescents-with-ptsd-after-childhood-sexual-abuse
#8
Mirjam A Rinne-Albers, J Nienke Pannekoek, Marie-José van Hoof, Natasja D van Lang, Francien Lamers-Winkelman, Serge A Rombouts, Nic J van der Wee, Robert R Vermeiren
Adverse childhood experiences (ACE) substantially increase the risk of later psychiatric and somatic pathology. While neurobiological factors are likely to play a mediating role, specific insights are lacking. The scarce neuroimaging studies in traumatised pediatric populations have provided inconsistent results, potentially due to the inclusion of different types of trauma. To further improve our understanding of the neurobiology of pediatric psychotrauma, this study seeks to investigate abnormalities in grey matter volume (GMV) in a homogeneous group of adolescents with posttraumatic stress disorder (PTSD) due to childhood sexual abuse (CSA) and the relationship between GMV and symptom severity...
September 6, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28888031/disconnection-of-hippocampal-networks-contributes-to-memory-dysfunction-in-individuals-with-temporal-lobe-epilepsy
#9
Travis R Stoub, Ada V Chicharro, Christopher L Grote, Andres M Kanner
A deficit in declarative memory function is common among individuals with temporal lobe epilepsy. The purpose of this study is to evaluate the relationship between the volume of the hippocampus, entorhinal cortex along with the surrounding parahippocampal white matter and memory performance in those with temporal lobe epilepsy. T1 weighted MRI scans were acquired using a 3-D pulse sequence in 50 individuals with temporal lobe epilepsy. Hippocampal and entorhinal cortex volumes were derived by manually tracing consecutive coronal slices aligned perpendicular to the long axis of the hippocampus...
September 9, 2017: Hippocampus
https://www.readbyqxmd.com/read/28883807/comparing-cat12-and-vbm8-for-detecting-brain-morphological-abnormalities-in-temporal-lobe-epilepsy
#10
Farnaz Farokhian, Iman Beheshti, Daichi Sone, Hiroshi Matsuda
The identification of the brain morphological alterations that play important roles in neurodegenerative/neurological diseases will contribute to our understanding of the causes of these diseases. Various automated software programs are designed to provide an automatic framework to detect brain morphological changes in structural magnetic resonance imaging (MRI) data. A voxel-based morphometry (VBM) analysis can also be used for the detection of brain volumetric abnormalities. Here, we compared gray matter (GM) and white matter (WM) abnormality results obtained by a VBM analysis using the Computational Anatomy Toolbox (CAT12) via the current version of Statistical Parametric Mapping software (SPM12) with the results obtained by a VBM analysis using the VBM8 toolbox implemented in the older software SPM8, in adult temporal lobe epilepsy (TLE) patients with (n = 51) and without (n = 57) hippocampus sclerosis (HS), compared to healthy adult controls (n = 28)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28871117/conjoint-and-dissociated-structural-and-functional-abnormalities-in-first-episode-drug-naive-patients-with-major-depressive-disorder-a-multimodal-meta-analysis
#11
Weina Wang, Youjin Zhao, Xinyu Hu, Xiaoqi Huang, Weihong Kuang, Su Lui, Graham J Kemp, Qiyong Gong
Published MRI evidence of structural and resting-state functional brain abnormalities in MDD has been inconsistent. To eliminate interference by repeated disease episodes and antidepressant treatment, we conducted the first multimodal voxel-wise meta-analysis of studies of voxel-based morphometry (VBM) and the amplitude of low-frequency fluctuation (ALFF) in first-episode drug-naive MDD patients, using the Seed-based d Mapping method (SDM). Fifteen VBM data sets and 11 ALFF data sets were included. SDM-based multimodal meta-analysis was used to highlight brain regions with both structural and functional abnormalities...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28856766/gray-matter-asymmetries-in-aging-and-neurodegeneration-a-review-and-meta-analysis
#12
Lora Minkova, Annegret Habich, Jessica Peter, Christoph P Kaller, Simon B Eickhoff, Stefan Klöppel
Inter-hemispheric asymmetries are a common phenomenon of the human brain. Some evidence suggests that neurodegeneration related to aging and disease may preferentially affect the left-usually language- and motor-dominant-hemisphere. Here, we used activation likelihood estimation meta-analysis to assess gray matter (GM) loss and its lateralization in healthy aging and in neurodegeneration, namely, mild cognitive impairment (MCI), Alzheimer's dementia (AD), Parkinson's disease (PD), and Huntington's disease (HD)...
August 30, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28833690/changes-in-structure-and-perfusion-of-grey-matter-tissues-during-recovery-from-ischaemic-subcortical-stroke-a-longitudinal-mri-study
#13
Xinfeng Yu, Linglin Yang, Ruirui Song, Yerfan Jiaerken, Jun Yang, Min Lou, Quan Jiang, Minming Zhang
Stroke recovery with changes in volume and perfusion of grey matter (GM) tissues remains largely unknown. We hypothesized that GM atrophy co-existed with GM plasticity presenting with increased volume and perfusion in specific regions in the period of post-stroke recovery. Twelve well-recovered stroke patients with pure subcortical lesions in the middle cerebral artery-perfused zone were included. All of them underwent structural and perfusion magnetic resonance imaging (MRI) examinations at admission and a mean of 6 months after stroke onset...
October 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28828757/longitudinal-alterations-of-local-spontaneous-brain-activity-in-parkinson-s-disease
#14
Qiaoling Zeng, Xiaojun Guan, Jason C F Law Yan Lun, Zhujing Shen, Tao Guo, Min Xuan, Quanquan Gu, Xiaojun Xu, Min Chen, Minming Zhang
We used resting-state fMRI to evaluate longitudinal alterations in local spontaneous brain activity in Parkinson's disease (PD) over a 2-year period. Data were acquired from 23 PD patients at baseline and follow-up, and 27 age- and sex-matched normal controls. Regional homogeneity (ReHo) and voxel-based-morphometry (VBM) were used to identify differences in local spontaneous brain activity and grey matter volume. With disease progression, we observed a progressive decrease in ReHo in the sensorimotor cortex, default-mode network, and left cerebellum, but increased ReHo in the supplementary motor area, bilateral temporal gyrus, and hippocampus...
August 21, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28828207/cerebral-gray-matter-volume-reduction-in-subcortical-vascular-mild-cognitive-impairment-patients-and-subcortical-vascular-dementia-patients-and-its-relation-with-cognitive-deficits
#15
Maoyu Li, Yao Meng, Minzhong Wang, Shuang Yang, Hui Wu, Bin Zhao, Guangbin Wang
INTRODUCTION: Subcortical vascular mild cognitive impairment (svMCI) is the predementia stage of subcortical vascular dementia (SVaD). The aim of this research is to explore and compare cerebral gray matter (GM) volume reduction in svMCI patients and SVaD patients, and to investigate the relationship between cerebral GM volume reduction and cognitive deficits. METHODS: Thirty one svMCI patients, 29 SVaD patients, and 31 healthy controls were recruited in our research...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28797599/magnetic-resonance-spectroscopy-analysis-of-neurochemical-changes-in-the-atrophic-hippocampus-of-app-ps1-transgenic-mice
#16
Shengxiang Liang, Jia Huang, Weilin Liu, Hao Jin, Long Li, Xiufeng Zhang, Binbin Nie, Ruhui Lin, Jing Tao, Shujun Zhao, Baoci Shan, Lidian Chen
Alzheimer's disease (AD) is characterized by neuropathological changes and progressive cognitive decline, which is associated with the volume loss and neurochemical alterations. However, the specific neurochemical alterations in cerebral regions that contribute to cognitive decline still remain unknown. In the present study, we measured cerebral morphological and neurochemical alterations using structural magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy ((1)H-MRS) in an AD model of APP/PS1 transgenic mice...
August 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28780167/emotion-related-brain-structures-associated-with-trait-creativity-in-middle-children
#17
Yunman Xia, Kaixiang Zhuang, Jiangzhou Sun, Qunlin Chen, Dongtao Wei, Wenjing Yang, Jiang Qiu
Middle childhood is an important period for individual trait shaping, during which children are likely to generate and own their distinct neuromechanism of creative-related traits. This study used voxel-based morphometry (VBM) to identify the brain structures that underlie trait creativity (as measured by the Williams Creativity Aptitude Test) in a sample of typical developing children (aged 9-12, n=64). The results indicated that several emotion-related regions may relate to trait creativity in middle children...
September 29, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28734177/manual-morphometry-of-hippocampus-and-amygdala-in-adults-with-attention-deficit-hyperactivity-disorder
#18
Kathrin Nickel, Ludger Tebartz van Elst, Evgeniy Perlov, Renate Jitten-Schachenmeier, Daniel Beier, Dominique Endres, Peter Goll, Alexandra Philipsen, Simon Maier
Previous studies have pointed to the involvement of limbic structures in the genesis of attention deficit hyperactivity disorder (ADHD). The present researchers manually segmented magnetic resonance images of 30 individuals with ADHD and 30 individually matched controls, focusing on amygdala and hippocampus volumes. Neither hippocampus nor amygdala volume differed significantly between individuals with and without ADHD. However, ADHD patients with higher hyperactivity scores had significantly smaller left amygdala volumes...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28729939/feature-selective-temporal-prediction-of-alzheimer-s-disease-progression-using-hippocampus-surface-morphometry
#19
Sinchai Tsao, Niharika Gajawelli, Jiayu Zhou, Jie Shi, Jieping Ye, Yalin Wang, Natasha Leporé
INTRODUCTION: Prediction of Alzheimer's disease (AD) progression based on baseline measures allows us to understand disease progression and has implications in decisions concerning treatment strategy. To this end, we combine a predictive multi-task machine learning method (cFSGL) with a novel MR-based multivariate morphometric surface map of the hippocampus (mTBM) to predict future cognitive scores of patients. METHODS: Previous work has shown that a multi-task learning framework that performs prediction of all future time points simultaneously (cFSGL) can be used to encode both sparsity as well as temporal smoothness...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28697581/altered-gray-matter-volume-and-functional-connectivity-of-the-motor-network-in%C3%A2-young%C3%A2-divers
#20
Xia Liu, Liansheng Liu, Fen Hou, Zhifeng Zhou, Qingying Wu, Hengguo Li
BACKGROUND: Motor learning and professional sports training can induce plastic changes in brain structures that are associated with distinct training demands. OBJECTIVE: To testify the hypothesis of that regional gray matter structures in the motor-related cortex and its functional connectivity (FC) are altered in young divers. METHODS: We undertook T1-voxel-based morphometry (VBM) structural and resting-state functional magnetic resonance imaging in groups of diving athletes (DAs) and demographically-matched healthy controls...
July 7, 2017: Journal of X-ray Science and Technology
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