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Hippocampus morphometry

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https://www.readbyqxmd.com/read/28797599/magnetic-resonance-spectroscopy-analysis-of-neurochemical-changes-in-the-atrophic-hippocampus-of-app-ps1-transgenic-mice
#1
Shengxiang Liang, Jia Huang, Weilin Liu, Hao Jin, Long Li, Xiufeng Zhang, Binbin Nie, Ruhui Lin, Jing Tao, Shujun Zhao, Baoci Shan, Lidian Chen
Alzheimer's disease (AD) is characterized by neuropathological changes and progressive cognitive decline, which is associated with the volume loss and neurochemical alterations. However, the specific neurochemical alterations in cerebral regions that contribute to cognitive decline still remain unknown. In the present study, we measured cerebral morphological and neurochemical alterations using structural magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy ((1)H-MRS) in an AD model of APP/PS1 transgenic mice...
August 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28780167/emotion-related-brain-structures-associated-with-trait-creativity-in-middle-children
#2
Kaixiang Zhuang, Yunman Xia, Jiangzhou Sun, Qunlin Chen, Dongtao Wei, Wenjing Yang, Jiang Qiu
Middle childhood is an important period for individual trait shaping, during which children are likely to generate and own their distinct neuromechanism of creative-related traits. This study used voxel-based morphometry (VBM) to identify the brain structures that underlie trait creativity (as measured by the Williams Creativity Aptitude Test) in a sample of typical developing children (aged 9-12, n=64). The results indicated that several emotion-related regions may relate to trait creativity in middle children...
August 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28734177/manual-morphometry-of-hippocampus-and-amygdala-in-adults-with-attention-deficit-hyperactivity-disorder
#3
Kathrin Nickel, Ludger Tebartz van Elst, Evgeniy Perlov, Renate Jitten-Schachenmeier, Daniel Beier, Dominique Endres, Peter Goll, Alexandra Philipsen, Simon Maier
Previous studies have pointed to the involvement of limbic structures in the genesis of attention deficit hyperactivity disorder (ADHD). The present researchers manually segmented magnetic resonance images of 30 individuals with ADHD and 30 individually matched controls, focusing on amygdala and hippocampus volumes. Neither hippocampus nor amygdala volume differed significantly between individuals with and without ADHD. However, ADHD patients with higher hyperactivity scores had significantly smaller left amygdala volumes...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28729939/feature-selective-temporal-prediction-of-alzheimer-s-disease-progression-using-hippocampus-surface-morphometry
#4
Sinchai Tsao, Niharika Gajawelli, Jiayu Zhou, Jie Shi, Jieping Ye, Yalin Wang, Natasha Leporé
INTRODUCTION: Prediction of Alzheimer's disease (AD) progression based on baseline measures allows us to understand disease progression and has implications in decisions concerning treatment strategy. To this end, we combine a predictive multi-task machine learning method (cFSGL) with a novel MR-based multivariate morphometric surface map of the hippocampus (mTBM) to predict future cognitive scores of patients. METHODS: Previous work has shown that a multi-task learning framework that performs prediction of all future time points simultaneously (cFSGL) can be used to encode both sparsity as well as temporal smoothness...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28697581/altered-gray-matter-volume-and-functional-connectivity-of-the-motor-network-in%C3%A2-young%C3%A2-divers
#5
Xia Liu, Liansheng Liu, Fen Hou, Zhifeng Zhou, Qingying Wu, Hengguo Li
BACKGROUND: Motor learning and professional sports training can induce plastic changes in brain structures that are associated with distinct training demands. OBJECTIVE: To testify the hypothesis of that regional gray matter structures in the motor-related cortex and its functional connectivity (FC) are altered in young divers. METHODS: We undertook T1-voxel-based morphometry (VBM) structural and resting-state functional magnetic resonance imaging in groups of diving athletes (DAs) and demographically-matched healthy controls...
July 7, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28695488/brain-structure-abnormalities-in-young-women-who-presented-conduct-disorder-in-childhood-adolescence
#6
Meenal Budhiraja, Ivanka Savic, Philip Lindner, Jussi Jokinen, Jari Tiihonen, Sheilagh Hodgins
The phenotype and genotype of antisocial behavior among females are different from those among males. Previous studies have documented structural brain alterations in males with antisocial behavior, yet little is known about the neural correlates of female antisocial behavior. The present study examined young women who had presented conduct disorder (CDW) prior to age 15 to determine whether brain abnormalities are present in adulthood and whether the observed abnormalities are associated with comorbid disorders or maltreatment that typically characterize this population...
July 10, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28580295/regional-brain-network-organization-distinguishes-the-combined-and-inattentive-subtypes-of-attention-deficit-hyperactivity-disorder
#7
Jacqueline F Saad, Kristi R Griffiths, Michael R Kohn, Simon Clarke, Leanne M Williams, Mayuresh S Korgaonkar
Attention Deficit Hyperactivity Disorder (ADHD) is characterized clinically by hyperactive/impulsive and/or inattentive symptoms which determine diagnostic subtypes as Predominantly Hyperactive-Impulsive (ADHD-HI), Predominantly Inattentive (ADHD-I), and Combined (ADHD-C). Neuroanatomically though we do not yet know if these clinical subtypes reflect distinct aberrations in underlying brain organization. We imaged 34 ADHD participants defined using DSM-IV criteria as ADHD-I (n = 16) or as ADHD-C (n = 18) and 28 matched typically developing controls, aged 8-17 years, using high-resolution T1 MRI...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28566104/attention-and-regional-gray-matter-development-in-very-preterm-children-at-age-12-years
#8
Rachel E Lean, Tracy R Melzer, Samudragupta Bora, Richard Watts, Lianne J Woodward
OBJECTIVES: This study examines the selective, sustained, and executive attention abilities of very preterm (VPT) born children in relation to concurrent structural magnetic resonance imaging (MRI) measures of regional gray matter development at age 12 years. METHODS: A regional cohort of 110 VPT (≤32 weeks gestation) and 113 full term (FT) born children were assessed at corrected age 12 years on the Test of Everyday Attention-Children. They also had a structural MRI scan that was subsequently analyzed using voxel-based morphometry to quantify regional between-group differences in cerebral gray matter development, which were then related to attention measures using multivariate methods...
June 1, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28549317/frontal-and-subcortical-grey-matter-reductions-in-ptsd
#9
Daniel C M O'Doherty, Ashleigh Tickell, Will Ryder, Charles Chan, Daniel F Hermens, Maxwell R Bennett, Jim Lagopoulos
Post-traumatic stress disorder (PTSD) is characterised by a range of debilitating psychological, physical and cognitive symptoms. PTSD has been associated with grey matter atrophy in limbic and frontal cortical brain regions. However, previous studies have reported heterogeneous findings, with grey matter changes observed beyond limbic/frontal areas. Seventy-five adults were recruited from the community, 25 diagnosed with PTSD along with 25 healthy and 25 trauma exposed age and gender matched controls. Participants underwent clinical assessment and magnetic resonance imaging...
May 19, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28536274/mapping-22q11-2-gene-dosage-effects-on-brain-morphometry
#10
Amy Lin, Christopher R K Ching, Ariana Vajdi, Daqiang Sun, Rachel K Jonas, Maria Jalbrzikowski, Leila Kushan-Wells, Laura Pacheco Hansen, Emma Krikorian, Boris Gutman, Deepika Dokoru, Gerhard Helleman, Paul M Thompson, Carrie E Bearden
Reciprocal chromosomal rearrangements at the 22q11.2 locus are associated with elevated risk of neurodevelopmental disorders. The 22q11.2 deletion confers the highest known genetic risk for schizophrenia, but a duplication in the same region is strongly associated with autism and is less common in schizophrenia cases than in the general population. Here we conducted the first study of 22q11.2 gene dosage effects on brain structure in a sample of 143 human subjects: 66 with 22q11.2 deletions (22q-del; 32 males), 21 with 22q11...
May 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28502846/domains-of-physical-activity-and-brain-volumes-a-population-based-study
#11
Carmen Jochem, Sebastian E Baumeister, Katharina Wittfeld, Michael F Leitzmann, Martin Bahls, Ulf Schminke, Marcello R P Markus, Stephan B Felix, Henry Völzke, Katrin Hegenscheid, Marcus Dörr, Hans Jörgen Grabe
Observational studies and intervention trials suggest that physical activity (PA) is beneficial for human brain morphology, especially in older individuals. Few population-based studies examined whether domain-specific PA is associated with brain volumes. Accordingly, we studied putative associations of PA during leisure time, sports and work with volumes of the hippocampus, the prefrontal cortex, the temporal lobe, gray matter (GM), white matter (WM) and total brain (TBV) after 5.9 years by applying volumetric analysis and voxel-based morphometry (VBM) with SPM 8/VBM 8 to brain magnetic resonance imaging data of 834 participants (447 women) aged 25 to 83 years from the population-based Study of Health in Pomerania...
May 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28495939/apoe-e4-is-associated-with-gray-matter-loss-in-the-posterior-cingulate-cortex-in-healthy-elderly-controls-subsequently-developing-subtle-cognitive-decline
#12
S Haller, M-L Montandon, C Rodriguez, M Ackermann, F R Herrmann, P Giannakopoulos
BACKGROUND AND PURPOSE: The presence of apolipoprotein E4 (APOE*E4) is the strongest currently known genetic risk factor for Alzheimer disease and is associated with brain gray matter loss, notably in areas involved in Alzheimer disease pathology. Our objective was to assess the effect of APOE*E4 on brain structures in healthy elderly controls who subsequently developed subtle cognitive decline. MATERIALS AND METHODS: This prospective study included 382 community-dwelling elderly controls...
May 11, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28487515/auditory-target-and-novelty-processing-in-patients-with-unilateral-hippocampal-sclerosis-a-current-source-density-study
#13
Adrià Vilà-Balló, Clément François, David Cucurell, Júlia Miró, Mercè Falip, Montserrat Juncadella, Antoni Rodríguez-Fornells
The capacity to respond to novel events is crucial for adapting to the constantly changing environment. Here, we recorded 29-channel Event Related Brain Potentials (ERPs) during an active auditory novelty oddball paradigm and used for the first time Current Source Density-transformed Event Related Brain Potentials and associated time-frequency spectra to study target and novelty processing in a group of epileptic patients with unilateral damage of the hippocampus (N = 18) and in healthy matched control participants (N = 18)...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28459000/neuro-degeneration-profile-of-alzheimer-s-patients-a-brain-morphometry-study
#14
Silvio Ramos Bernardes da Silva Filho, Jeam Haroldo Oliveira Barbosa, Carlo Rondinoni, Antonio Carlos Dos Santos, Carlos Ernesto Garrido Salmon, Nereida Kilza da Costa Lima, Eduardo Ferriolli, Júlio César Moriguti
INTRODUCTION: Alzheimer's disease (AD) is a primary and progressive neurodegenerative disorder, which is marked by cognitive deterioration and memory impairment. Atrophy of hippocampus and other basal brain regions is one of the most predominant structural imaging findings related to AD. Most studies have evaluated the pre-clinical and initial stages of AD through clinical trials using Magnetic Resonance Imaging. Structural biomarkers for advanced AD stages have not been evaluated yet, being considered only hypothetically...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28451633/individual-differences-in-human-path-integration-abilities-correlate-with-gray-matter-volume-in-retrosplenial-cortex-hippocampus-and-medial-prefrontal-cortex
#15
Elizabeth R Chrastil, Katherine R Sherrill, Irem Aselcioglu, Michael E Hasselmo, Chantal E Stern
Humans differ in their individual navigational abilities. These individual differences may exist in part because successful navigation relies on several disparate abilities, which rely on different brain structures. One such navigational capability is path integration, the updating of position and orientation, in which navigators track distances, directions, and locations in space during movement. Although structural differences related to landmark-based navigation have been examined, gray matter volume related to path integration ability has not yet been tested...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28450849/striatal-and-hippocampal-atrophy-in-idiopathic-parkinson-s-disease-patients-without-dementia-a-morphometric-analysis
#16
Jared J Tanner, Nikolaus R McFarland, Catherine C Price
BACKGROUND: Analyses of subcortical gray structure volumes in non-demented idiopathic Parkinson's disease (PD) often, but not always, show volume loss of the putamen, caudate nucleus, nucleus accumbens, and hippocampus. There is building evidence that structure morphometry might be more sensitive to disease-related processes than volume. OBJECTIVE: To assess morphometric differences of subcortical structures (putamen, caudate nucleus, thalamus, globus pallidus, nucleus accumbens, and amygdala) as well as the hippocampus in non-demented individuals with PD relative to age and education matched non-PD peers...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28450073/cerebral-magnetic-resonance-changes-associated-with-fibromyalgia-syndrome
#17
REVIEW
Iñigo Murga, Virginia Guillen, José-Vicente Lafuente
Fibromyalgia syndrome is a chronic disease, of unknown origin, whose diagnostic criteria were established in 1990 by the American College of Rheumatology. New criteria were proposed in 2010 that have not yet been validated. It is characterized by a generalized chronic musculoskeletal pain, accompanied by hyperalgesia and allodynia, as well as other motor, vegetative, cognitive and affective symptoms and signs. We have reviewed a set of studies with cerebral magnetic resonance (morphometry, connectivity and spectroscopy) that refer to changes in areas involved in pain processing...
April 24, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28390437/brain-structural-investigation-and-hippocampal-tractography-in-medication-overuse-headache-a-native-space-analysis
#18
M Meyer, G Di Scala, M Edde, B Dilharreguy, F Radat, M Allard, S Chanraud
BACKGROUND: Spatial normalization of brain images, a prerequisite for voxel based morphometry analysis, may account for the large variability of the volumetric data in medication overuse headache (MOH); possibly because this disease concerns patients differing on both sex and age, and hence with different brain size and shape. METHODS: The present study aimed at providing a subject-based analysis of macrostructure using a native space volumes segmentation (Freesurfer), and microstructure using a region of interest (ROI: i...
April 8, 2017: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/28369850/an-mri-study-of-the-corpus-callosum-in-monkeys-developmental-trajectories-and-effects-of-neonatal-hippocampal-and-amygdala-lesions
#19
Christa Payne, Laetitia Cirilli, Jocelyne Bachevalier
This study provides the first characterization of early developmental trajectories of corpus callosum (CC) segments in rhesus macaques using noninvasive MRI techniques and assesses long-term effects of neonatal amygdala or hippocampal lesions on CC morphometry. In Experiment 1, 10 monkeys (5 males) were scanned at 1 week-2 years of age; eight additional infants (4 males) were scanned once at 1-4 weeks of age. The first 8 months showed marked growth across all segments, with sustained, albeit slower, growth through 24 months...
May 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28340448/structural-correlates-of-creative-thinking-in-patients-with-bipolar-disorder-and-healthy-controls-a-voxel-based-morphometry-study
#20
Pei-Chi Tu, Yi-Hsuan Kuan, Cheng-Ta Li, Tung-Ping Su
BACKGROUND: This study investigated the structural correlates of creative thinking in patients with bipolar disorder (BD) to understand the possible neural mechanism of creative thinking in BD. METHODS: We recruited 59 patients with BD I or BD II (35.3±8.5 y) and 56 age- and sex-matched controls (HCs; 34±7.4 y). Each participant underwent structural magnetic resonance imaging and evaluation of creative thinking, which was assessed using two validated tools: the Chinese version of the Abbreviated Torrance Test for Adults for divergent thinking and the Chinese Word Remote Associates Test for remote association...
June 2017: Journal of Affective Disorders
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