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Hippocampus morphometry

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https://www.readbyqxmd.com/read/27893017/evaluation-of-cognitive-deficits-and-structural-hippocampal-damage-in-encephalitis-with-leucine-rich-glioma-inactivated-1-antibodies
#1
Carsten Finke, Harald Prüss, Josephine Heine, Sigrid Reuter, Ute A Kopp, Florian Wegner, Florian Then Bergh, Sebastian Koch, Olav Jansen, Thomas Münte, Günther Deuschl, Klemens Ruprecht, Winfried Stöcker, Klaus-Peter Wandinger, Friedemann Paul, Thorsten Bartsch
Importance: Limbic encephalitis with leucine-rich, glioma-inactivated 1 (LGI1) antibodies is one of the most frequent variants of autoimmune encephalitis with antibodies targeting neuronal surface antigens. However, the neuroimaging pattern and long-term cognitive outcome are not well understood. Objective: To study cognitive outcome and structural magnetic resonance imaging (MRI) alterations in patients with anti-LGI1 encephalitis. Design, Setting, and Participants: A cross-sectional study was conducted at the Departments of Neurology at Charité-Universitätsmedizin Berlin and University Hospital Schleswig-Holstein, Kiel, Germany...
November 21, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27888657/electroconvulsive-therapy-induced-brain-structural-and-functional-changes-in-major-depressive-disorders-a-longitudinal-study
#2
Haitang Qiu, Xirong Li, Wenjing Zhao, Lian Du, Peiyu Huang, Yixiao Fu, Tian Qiu, Peng Xie, Huaqing Meng, Qinghua Luo
BACKGROUND This study aimed to study the brain structural and functional changes after 8 courses of electroconvulsive therapy (ECT) on patients with major depressive disorder (MDD). MATERIAL AND METHODS MRI scans were performed on 12 depressive patients before and after 8 courses of ECT and compared with those of 15 normal controls. Data were analyzed by voxel-based morphometry (VBM) using SPM8 software. Functional MRI (fMRI) and regional homogeneity (ReHo) analyses were used to assess the functional changes after ECT...
November 26, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27833805/whole-brain-ex-vivo-quantitative-mri-of-the-cuprizone-mouse-model
#3
Tobias C Wood, Camilla Simmons, Samuel A Hurley, Anthony C Vernon, Joel Torres, Flavio Dell'Acqua, Steve C R Williams, Diana Cash
Myelin is a critical component of the nervous system and a major contributor to contrast in Magnetic Resonance (MR) images. However, the precise contribution of myelination to multiple MR modalities is still under debate. The cuprizone mouse is a well-established model of demyelination that has been used in several MR studies, but these have often imaged only a single slice and analysed a small region of interest in the corpus callosum. We imaged and analyzed the whole brain of the cuprizone mouse ex-vivo using high-resolution quantitative MR methods (multi-component relaxometry, Diffusion Tensor Imaging (DTI) and morphometry) and found changes in multiple regions, including the corpus callosum, cerebellum, thalamus and hippocampus...
2016: PeerJ
https://www.readbyqxmd.com/read/27778407/the-effects-of-hiv-and-aging-on-subcortical-shape-alterations-a-3d-morphometric-study
#4
Taylor Kuhn, Daniel Schonfeld, Philip Sayegh, Alyssa Arentoft, Jacob D Jones, Charles H Hinkin, Susan Y Bookheimer, April D Thames
Standard volumetric neuroimaging studies have demonstrated preferential atrophy of subcortical structures among individuals with HIV. However, to our knowledge, no study has investigated subcortical shape alterations secondary to HIV and whether advancing age impacts that relationship. This study employed 3D morphometry to examine the independent and interactive effects of HIV and age on shape differences in nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus in 81 participants ranging in age from 24 to 76 including 59 HIV+ individuals and 22 HIV-seronegative controls...
October 25, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27776571/common-pattern-of-gray-matter-abnormalities-in-drug-naive-and-medicated-first-episode-schizophrenia-a-multimodal-meta-analysis
#5
C Shah, W Zhang, Y Xiao, L Yao, Y Zhao, X Gao, L Liu, J Liu, S Li, B Tao, Z Yan, Y Fu, Q Gong, S Lui
Studies of schizophrenia at drug-naive state and on antipsychotic medication have reported a number of regions of gray-matter (GM) abnormalities but the reports have been inconsistent. The aim of this study was to conduct multimodal meta-analysis to compare the cross-sectional voxel-based morphometry studies of brain GM in antipsychotic-naive first-episode schizophrenia (AN-FES) and those with antipsychotic treatment within 1 year (AT-FES) to determine the similarities and differences in these groups. We conducted two separate meta-analyses containing 24 studies with a sample size of 801 patients and 957 healthy controls...
October 25, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27734300/early-effects-of-a-high-caloric-diet-and-physical-exercise-on-brain-volumetry-and-behavior-a-combined-mri-and-histology-study-in-mice
#6
Markus Sack, Jenny N Lenz, Mira Jakovcevski, Sarah V Biedermann, Claudia Falfán-Melgoza, Jan Deussing, Maximilian Bielohuby, Martin Bidlingmaier, Frederik Pfister, Günter K Stalla, Alexander Sartorius, Peter Gass, Wolfgang Weber-Fahr, Johannes Fuss, Matthias K Auer
Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating early effects of a cafeteria-diet on gray and white brain matter volume by means of voxel-based morphometry (VBM) and region-of-interest (ROI) analysis. Half of the mice performed voluntary wheel running to study if regular physical exercise prevents unfavorable effects of a cafeteria-diet...
October 12, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27723806/voxel-based-morphometry-in-individuals-at-genetic-high-risk-for-schizophrenia-and-patients-with-schizophrenia-during-their-first-episode-of-psychosis
#7
Miao Chang, Fay Y Womer, Chuan Bai, Qian Zhou, Shengnan Wei, Xiaowei Jiang, Haiyang Geng, Yifang Zhou, Yanqing Tang, Fei Wang
BACKGROUND: Understanding morphologic changes in vulnerable and early disease state of schizophrenia (SZ) may provide further insight into the development of psychosis. METHOD: Whole brain voxel-based morphometry was performed to identify gray matter (GM) regional differences in 60 individuals with SZ during their first psychotic episode (FE-SZ), 31 individuals at genetic high risk for SZ (GHR-SZ) individuals, and 71 healthy controls. RESULTS: Significant differences were found in several regions including the prefrontal cortex, parietal lobe, temporal lobe, hippocampus, occipital lobe, and cerebellum among the three groups (p<0...
2016: PloS One
https://www.readbyqxmd.com/read/27698649/progressively-disrupted-intrinsic-functional-connectivity-of-basolateral-amygdala-in-very-early-alzheimer-s-disease
#8
Marion Ortner, Lorenzo Pasquini, Martina Barat, Panagiotis Alexopoulos, Timo Grimmer, Stefan Förster, Janine Diehl-Schmid, Alexander Kurz, Hans Förstl, Claus Zimmer, Afra Wohlschläger, Christian Sorg, Henning Peters
Very early Alzheimer's disease (AD) - i.e., AD at stages of mild cognitive impairment (MCI) and mild dementia - is characterized by progressive structural and neuropathologic changes, such as atrophy or tangle deposition in medial temporal lobes, including hippocampus and entorhinal cortex and also adjacent amygdala. While progressively disrupted intrinsic connectivity of hippocampus with other brain areas has been demonstrated by many studies, amygdala connectivity was rarely investigated in AD, notwithstanding its known relevance for emotion processing and mood disturbances, which are both important in early AD...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27668175/changes-of-grey-matter-volume-in-first-episode-drug-naive-adult-major-depressive-disorder-patients-with-different-age-onset
#9
Zonglin Shen, Yuqi Cheng, Shuran Yang, Nan Dai, Jing Ye, Xiaoyan Liu, Jin Lu, Na Li, Fang Liu, Yi Lu, Xuejin Sun, Xiufeng Xu
OBJECTIVE: Little is known about the pathological mechanism of early adult onset depression (EOD) and later adult onset depression (LOD). We seek to determine whether grey matter volume (GMV) change in EOD and LOD are different, which could also delineate EOD and LOD. METHODS: In present study, 147 first-episode, drug-naive patients with major depressive disorder (MDD), age between 18 and 45, were divided into two groups on the basis of age of MDD onset: the early adult onset group (age 18-29) and the later adult onset group (age 30-44), and a total of 130 gender-, and age-, matched healthy controls (HC) were also divided into two groups which fit for each patient group...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27625988/psychological-intervention-with-working-memory-training-increases-basal-ganglia-volume-a-vbm-study-of-inpatient-treatment-for-methamphetamine-use
#10
S J Brooks, K H Burch, S A Maiorana, E Cocolas, H B Schioth, E K Nilsson, K Kamaloodien, D J Stein
BACKGROUND: Protracted methamphetamine (MA) use is associated with decreased control over drug craving and altered brain volume in the frontostriatal network. However, the nature of volumetric changes following a course of psychological intervention for MA use is not yet known. METHODS: 66 males (41 MA patients, 25 healthy controls, HC) between the ages of 18-50 were recruited, the MA patients from new admissions to an in-patient drug rehabilitation centre and the HC via public advertisement, both in Cape Town, South Africa...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27623782/basic-mr-sequence-parameters-systematically-bias-automated-brain-volume-estimation
#11
Sven Haller, Pavel Falkovskiy, Reto Meuli, Jean-Philippe Thiran, Gunnar Krueger, Karl-Olof Lovblad, Tobias Kober, Alexis Roche, Bénédicte Marechal
INTRODUCTION: Automated brain MRI morphometry, including hippocampal volumetry for Alzheimer disease, is increasingly recognized as a biomarker. Consequently, a rapidly increasing number of software tools have become available. We tested whether modifications of simple MR protocol parameters typically used in clinical routine systematically bias automated brain MRI segmentation results. METHODS: The study was approved by the local ethical committee and included 20 consecutive patients (13 females, mean age 75...
November 2016: Neuroradiology
https://www.readbyqxmd.com/read/27615373/increased-perceived-stress-is-related-to-decreased-prefrontal-cortex-volumes-among-older-adults
#12
Georgina L Moreno, Joel Bruss, Natalie L Denburg
INTRODUCTION: Several of the brain regions vulnerable to increased levels of stress (i.e., hippocampus and prefrontal cortex) are also known to undergo disproportionate decline during normal aging. To date, surprisingly little research has examined the effects of stress on the brain among healthy human populations, much less in the elderly. The aim of the current study was to investigate the relationship between chronic stress and brain morphometry in regions known for their involvement in the stress response, namely the prefrontal cortex, hippocampus, and amygdala, in a sample of healthy older adults...
September 11, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27567843/atrophy-in-alzheimer-s-disease-and%C3%A2-semantic-dementia-an-ale-meta-analysis-of-voxel-based-morphometry-studies
#13
Marianne Chapleau, Joséphine Aldebert, Maxime Montembeault, Simona M Brambati
BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) and semantic dementia (SD) have distinct episodic memory profiles despite the hippocampal atrophy that characterizes both diseases. The aim of this study was to delineate the pattern of gray matter (GM) atrophy associated with AD and SD as well as any differences in these patterns by pooling together the results of previous voxel-based morphometry (VBM) studies.Methods/Overview: We conducted a meta-analysis of VBM studies that investigated GM atrophy in AD patients versus controls (CTRLs) and in SD patients versus CTRLs using the activation likelihood estimation (ALE) approach...
October 4, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27535407/education-is-associated-with-sub-regions-of-the-hippocampus-and-the-amygdala-vulnerable-to-neuropathologies-of-alzheimer-s-disease
#14
Xiaoying Tang, Vijay R Varma, Michael I Miller, Michelle C Carlson
We evaluated the correlation of educational attainment with structural volume and shape morphometry of the bilateral hippocampi and amygdalae in a sample of 110 non-demented, older adults at elevated sociodemographic risk for cognitive and functional declines. In both men and women, no significant education-volume correlation was detected for either structure. However, when performing shape analysis, we observed regionally specific associations with education after adjusting for age, intracranial volume, and race...
August 17, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27531235/understanding-heterogeneity-in-grey-matter-research-of-adults-with-childhood-maltreatment-a-meta-analysis-and-review
#15
Casey Paquola, Maxwell R Bennett, Jim Lagopoulos
Childhood trauma has been associated with long term effects on prefrontal-limbic grey matter. A literature search was conducted to identify structural magnetic resonance imaging studies of adults with a history of childhood trauma. We performed three meta-analyses. Hedges' g effect sizes were calculated for each study providing hippocampal or amygdala volumes of trauma and non-trauma groups. Seed based differential mapping was utilised to synthesise whole brain voxel based morphometry (VBM) studies. A total of 38 articles (17 hippocampus, 13 amygdala, 19 whole brain VBM) were included in the meta-analyses...
October 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27528091/tnf-receptors-1-and-2-exert-distinct-region-specific-effects-on-striatal-and-hippocampal-grey-matter-volumes-vbm-in-healthy-adults
#16
D Stacey, R Redlich, A Büschel, N Opel, D Grotegerd, D Zaremba, K Dohm, C Bürger, S L Meinert, K Förster, J Repple, C Kaufmann, H Kugel, W Heindel, V Arolt, U Dannlowski, B T Baune
Tumour necrosis factor alpha (TNFα) has been implicated in the pathophysiology of neurodegenerative and neuropsychiatric disease, with research highlighting a role for TNFα in hippocampal and striatal regulation. TNFα signals are primarily transduced by TNF receptors 1 and 2 (TNFR1 and TNFR2), encoded by TNFRSF1A and TNFRSF1B, which exert opposing effects on cell survival (TNFR1, neurodegenerative; TNFR2, neuroprotective). We therefore sought to explore the respective roles of TNFR1 and TNFR2 in the regulation of hippocampal and striatal morphology in an imaging genetics study...
August 16, 2016: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27516217/chronic-exposure-to-haloperidol-and-olanzapine-leads-to-common-and-divergent-shape-changes-in-the-rat-hippocampus-in-the-absence-of-grey-matter-volume-loss
#17
W R Crum, F Danckaers, T Huysmans, M-C Cotel, S Natesan, M M Modo, J Sijbers, S C R Williams, S Kapur, A C Vernon
BACKGROUND: One of the most consistently reported brain abnormalities in schizophrenia (SCZ) is decreased volume and shape deformation of the hippocampus. However, the potential contribution of chronic antipsychotic medication exposure to these phenomena remains unclear. METHOD: We examined the effect of chronic exposure (8 weeks) to clinically relevant doses of either haloperidol (HAL) or olanzapine (OLZ) on adult rat hippocampal volume and shape using ex vivo structural MRI with the brain retained inside the cranium to prevent distortions due to dissection, followed by tensor-based morphometry (TBM) and elastic surface-based shape deformation analysis...
November 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27499828/morphometric-analysis-of-hippocampus-and-lateral-ventricle-reveals-regional-difference-between-cognitively-stable-and-declining-persons
#18
Wen Zhang, Jie Shi, Cynthia Stonnington, Robert J Bauer, Boris A Gutman, Kewei Chen, Paul M Thompson, Eric M Reiman, Richard J Caselli, Yalin Wang
Alzheimers disease (AD) is a progressive neurodegenerative disease most prevalent in the elderly. Distinguishing disease-related memory decline from normal age-related memory decline has been clinically difficult due to the subtlety of cognitive change during the preclinical stage of AD. In contrast, sensitive biomarkers derived from in vivo neuroimaging data could improve the early identification of AD. In this study, we employed a morphometric analysis in the hippocampus and lateral ventricle. A novel group-wise template-based segmentation algorithm was developed for ventricular segmentation...
April 2016: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/27473839/exploring-anterograde-memory-a-volumetric-mri-study-in-patients-with-mild-cognitive-impairment
#19
N Philippi, V Noblet, E Duron, B Cretin, C Boully, I Wisniewski, M L Seux, C Martin-Hunyadi, E Chaussade, C Demuynck, S Kremer, S Lehéricy, D Gounot, J P Armspach, O Hanon, F Blanc
BACKGROUND: The aim of this volumetric study was to explore the neuroanatomical correlates of the Free and Cued Selective Reminding Test (FCSRT) and the Delayed Matching-to-Sample-48 items (DMS-48), two tests widely used in France to assess verbal and visual anterograde memory. We wanted to determine to what extent the two tests rely on the medial temporal lobe, and could therefore be predictive of Alzheimer's disease, in which pathological changes typically start in this region. METHODS: We analysed data from a cohort of 138 patients with mild cognitive impairment participating in a longitudinal multicentre clinical research study...
July 30, 2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27470229/high-avidity-hsv-1-antibodies-correlate-with-absence-of-amnestic-mild-cognitive-impairment-conversion-to-alzheimer-s-disease
#20
Simone Agostini, Roberta Mancuso, Francesca Baglio, Monia Cabinio, Ambra Hernis, Andrea Saul Costa, Elena Calabrese, Raffaello Nemni, Mario Clerici
Amnestic Mild Cognitive Impairment (aMCI) is an alteration in cognitive abilities that can progress to Alzheimer's disease (AD), a condition in which herpes simplex type 1 (HSV-1) infection might play a pathogenetic role. Prognostic indexes capable of predicting aMCI conversion to AD are only partially understood. The objective of the present work is to verify whether HSV-1 immune responses is involved in conversion of aMCI to AD and correlate with grey matter brain morphometry. Two homogeneous groups of individuals who did or did not convert to AD over a 24-months period were selected after retrospective analysis of a cohort of patients with a diagnosis of aMCI...
November 2016: Brain, Behavior, and Immunity
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