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Hippocampus morphometry

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https://www.readbyqxmd.com/read/28275349/neuroanatomical-and-neuropsychological-markers-of-amnestic-mci-a-three-year-longitudinal-study-in-individuals-unaware-of-cognitive-decline
#1
Katharina S Goerlich, Mikhail Votinov, Ellen Dicks, Sinika Ellendt, Gábor Csukly, Ute Habel
Structural brain changes underlying mild cognitive impairment (MCI) have been well-researched, but most previous studies required subjective cognitive complaints (SCC) as a diagnostic criterion, diagnosed MCI based on a single screening test or lacked analyses in relation to neuropsychological impairment. This longitudinal voxel-based morphometry study aimed to overcome these limitations: The relationship between regional gray matter (GM) atrophy and behavioral performance was investigated over the course of 3 years in individuals unaware of cognitive decline, identified as amnestic MCI based on an extensive neuropsychological test battery...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28273899/in-vivo-microscopic-voxel-based-morphometry-with-a-brain-template-to-characterize-strain-specific-structures-in-the-mouse-brain
#2
Keigo Hikishima, Yuji Komaki, Fumiko Seki, Yasuyuki Ohnishi, Hirotaka J Okano, Hideyuki Okano
Hundreds of inbred mouse strains are established for use in a broad spectrum of basic research fields, including genetics, neuroscience, immunology, and cancer. Inbred mice exhibit identical intra-strain genetics and divergent inter-strain phenotypes. The cognitive and behavioral divergences must be controlled by the variances of structure and function of their brains; however, the underlying morphological features of strain-to-strain difference remain obscure. Here, in vivo microscopic magnetic resonance imaging was optimized to image the mouse brains by using an isotropic resolution of 80 μm...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28272153/brain-gray-matter-mri-morphometry-for-neuroprognostication-after-cardiac-arrest
#3
Stein Silva, Patrice Peran, Lionel Kerhuel, Briguita Malagurski, Nicolas Chauveau, Benoit Bataille, Jean Albert Lotterie, Pierre Celsis, Florent Aubry, Giuseppe Citerio, Betty Jean, Russel Chabanne, Vincent Perlbarg, Lionel Velly, Damien Galanaud, Audrey Vanhaudenhuyse, Olivier Fourcade, Steven Laureys, Louis Puybasset
OBJECTIVES: We hypothesize that the combined use of MRI cortical thickness measurement and subcortical gray matter volumetry could provide an early and accurate in vivo assessment of the structural impact of cardiac arrest and therefore could be used for long-term neuroprognostication in this setting. DESIGN: Prospective cohort study. SETTING: Five Intensive Critical Care Units affiliated to the University in Toulouse (France), Paris (France), Clermont-Ferrand (France), Liège (Belgium), and Monza (Italy)...
March 7, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28238738/reference-standard-space-hippocampus-labels-according-to-the-eadc-adni-harmonized-protocol-utility-in-automated-volumetry
#4
Dominik Wolf, Martina Bocchetta, Gregory M Preboske, Marina Boccardi, Michel J Grothe
BACKGROUND: A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated image analyses. METHODS: Manual HarP tracings on the high-resolution MNI152 standard space template of four expert certified HarP tracers were combined to obtain consensual bilateral hippocampus labels...
February 23, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28219620/brain-structural-correlates-of-executive-and-social-cognition-profiles-in-behavioral-variant-frontotemporal-dementia-and-elderly-bipolar-disorder
#5
Sandra Baez, Clara Pinasco, María Roca, Jesica Ferrari, Blas Couto, Indira García-Cordero, Agustín Ibañez, Francy Cruz, Pablo Reyes, Diana Matallana, Facundo Manes, Marcelo Cetcovich, Teresa Torralva
An early stage of behavioral variant frontotemporal dementia (bvFTD) often displays a mix of behavioral disturbances and personality changes hindering a differential diagnosis from elderly bipolar disorder (BD), making this process a big challenge. However, no studies have compared these pathologies from neuropsychological and neuroanatomical perspectives. The aim of the present study was to compare the executive functions (EF) and social cognition profiles as well as the structural neuroimaging of bvFTD and elderly patients with BD...
February 17, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28194282/localizing-age-related-changes-in-brain-structure-using-voxel-based-morphometry
#6
Shu Hua Mu, Min Xu, Jun Xiu Duan, Jian Zhang, Li Hai Tan
Aim. We report the dynamic anatomical sequence of human cortical gray matter development from late childhood to young adults using VBM and ROI-based methods. Method. The structural MRI of 91 normal individuals ranging in age from 6 to 26 years was obtained and the GMV for each region was measured. Results. Our results showed that the earliest loss of GMV occurred in left olfactory, right precuneus, caudate, left putamen, pallidum, and left middle temporal gyrus. In addition, the trajectory of maturational and aging showed a linear decline in GMV on both cortical lobes and subcortical regions...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28188659/hippocampal-subfields-at-ultra-high-field-mri-an-overview-of-segmentation-and-measurement-methods
#7
Alessia Giuliano, Graziella Donatelli, Mirco Cosottini, Michela Tosetti, Alessandra Retico, Maria Evelina Fantacci
The hippocampus is one of the most interesting and studied brain regions because of its involvement in memory functions and its vulnerability in pathological conditions, such as neurodegenerative processes. In the recent years, the increasing availability of Magnetic Resonance Imaging (MRI) scanners that operate at ultra-high field (UHF), i.e. with static magnetic field strength ≥ 7T, has opened new research perspectives. Compared to conventional high-field scanners, these systems can provide new contrasts, increased signal-to-noise ratio and higher spatial resolution, thus they may improve the visualization of very small structures of the brain, such as the hippocampal subfields...
February 11, 2017: Hippocampus
https://www.readbyqxmd.com/read/28176504/morphological-and-microstructural-changes-of-the-hippocampus-in-early-mci-a-study-utilizing-the-alzheimer-s-disease-neuroimaging-initiative-database
#8
Peter Lee, Hojin Ryoo, Jinah Park, Yong Jeong
BACKGROUND AND PURPOSE: With the aim of facilitating the early detection of Alzheimer's disease, the Alzheimer's Disease Neuroimaging Initiative proposed two stages based on the memory performance: early mild cognitive impairment (EMCI) and late mild cognitive impairment (LMCI). The current study was designed to investigate structural differences in terms of surface atrophy and microstructural changes of the hippocampus in EMCI and LMCI. METHODS: Hippocampal shape modeling based on progressive template surface deformation was performed on T1-weighted MRI images obtained from 20 cognitive normal (CN) subjects, 17 EMCI patients, and 20 LMCI patients...
January 25, 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28150390/gray-matter-relationships-to-diagnostic-and-transdiagnostic-features-of-drug-and-behavioral-addictions
#9
Sarah W Yip, Patrick D Worhunsky, Jiansong Xu, Kristen P Morie, R Todd Constable, Robert T Malison, Kathleen M Carroll, Marc N Potenza
Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combines categorical (diagnosis-based) and dimensional (transdiagnostic) approaches to identify neural structural alterations linked to addiction subtypes and trait impulsivity, respectively, across individuals with gambling disorder (n = 35), individuals with cocaine-use disorder (n = 37) and healthy comparison individuals (n = 37)...
February 1, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28131236/regional-volumetric-change-in-parkinson-s-disease-with-cognitive-decline
#10
Myrlene Gee, Juergen Dukart, Bogdan Draganski, W R Wayne Martin, Derek Emery, Richard Camicioli
BACKGROUND: Parkinson's disease (PD), characterized by motor dysfunction and cognitive decline, may demonstrate specific patterns of brain atrophy. Although cross-sectional magnetic resonance imaging (MRI) studies show correlation between regional brain volume loss and cognitive impairment, there is only scarce evidence from longitudinal studies validating the link between cognition and brain anatomy in PD. OBJECTIVE: To test the relationship between magnitude and spatial extent of atrophy in PD patients with progressive, significant cognitive decline and dementia (PDD)...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28099507/correlations-of-behavioral-deficits-with-brain-pathology-assessed-through-longitudinal-mri-and-histopathology-in-the-hdhq150-q150-mouse-model-of-huntington-s-disease
#11
Ivan Rattray, Edward J Smith, William R Crum, Thomas A Walker, Richard Gale, Gillian P Bates, Michel Modo
A variety of mouse models have been developed that express mutant huntingtin (mHTT) leading to aggregates and inclusions that model the molecular pathology observed in Huntington's disease. Here we show that although homozygous HdhQ150 knock-in mice developed motor impairments (rotarod, locomotor activity, grip strength) by 36 weeks of age, cognitive dysfunction (swimming T maze, fear conditioning, odor discrimination, social interaction) was not evident by 94 weeks. Concomitant to behavioral assessments, T2-weighted MRI volume measurements indicated a slower striatal growth with a significant difference between wild type (WT) and HdhQ150 mice being present even at 15 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28048182/su-g-iep1-14-the-relationship-between-voxel-based-morphometry-and-fiber-tract-abnormalities-by-correlation-analysis-in-patients-with-neurodegerative-disease
#12
R Juh, T Suh, J Han, C Kim, C Oh
PURPOSE: We evaluated the relationship between white matter (WM) tract disintegration and gray matter (GM) atrophy in patients with Alzheimer's disease (AD), mild cognitive impairment (MCI) and controls, using diffusion tensor imaging (DTI) and an optimized voxel-based analysis. METHODS: Two hundred thirty one individuals (61 controls, 116 MCI and 54 AD) were included. Voxel-based WM tract statistics was used to obtain whole-brain maps of WM bundles for FA. Voxel-based morphometry (VBM) was conducted to detect regions of gray matter (GM) atrophy in the AD, MCI group relative to the control group...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28031996/structural-and-functional-neural-correlates-of-spatial-navigation-a-combined-voxel-based-morphometry-and-functional-connectivity-study
#13
Xin Hao, Yi Huang, Xueting Li, Yiying Song, Xiangzhen Kong, Xu Wang, Zetian Yang, Zonglei Zhen, Jia Liu
INTRODUCTION: Navigation is a fundamental and multidimensional cognitive function that individuals rely on to move around the environment. In this study, we investigated the neural basis of human spatial navigation ability. METHODS: A large cohort of participants (N > 200) was examined on their navigation ability behaviorally and structural and functional magnetic resonance imaging (MRI) were then used to explore the corresponding neural basis of spatial navigation...
December 2016: Brain and Behavior
https://www.readbyqxmd.com/read/28018194/cross-sectional-and-longitudinal-relationships-between-depressive-symptoms-and-brain-atrophy-in-ms-patients
#14
Heiner Stuke, Katrin Hanken, Jochen Hirsch, Jan Klein, Fabian Wittig, Andreas Kastrup, Helmut Hildebrandt
Introduction: Depressive symptoms are a frequent and distressing phenomenon in Multiple Sclerosis (MS) patients. Cross-sectional research links these symptoms to reduced brain gray matter volumes in parts of the prefrontal and temporal lobe as well as subcortical structures like the hippocampus, nucleus caudatus and globus pallidus. Nevertheless, prospective relationships between regional gray matter volume and the course of depressive symptoms are poorly understood. Methods: Forty-four patients with relapsing-remitting or secondary progressive MS participated in a prospective study with two assessments of depressive symptoms and high-resolution MRI with an inter-test-interval of 17 months...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27989500/gray-matter-abnormalities-associated-with-fibromyalgia-a-meta-analysis-of-voxel-based-morphometric-studies
#15
HaiCun Shi, CongHu Yuan, ZhenYu Dai, HaiRong Ma, LiQin Sheng
OBJECTIVES: Studies employing voxel-based morphometry (VBM) have reported inconsistent findings on the association of gray matter (GM) abnormalities with fibromyalgia. The aim of the present study is to identify the most prominent and replicable GM areas that involved in fibromyalgia. METHODS: A systematic search of the PubMed database from January 2000 to September 2015 was performed to identify eligible whole-brain VBM studies. Comprehensive meta-analyses to investigate regional GM abnormalities in fibromyalgia were conducted with the Seed-based d Mapping software package...
December 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27981440/visceral-fat-is-associated-with-brain-structure-independent-of-human-immunodeficiency-virus-infection-status
#16
Jordan E Lake, Mikhail Popov, Wendy S Post, Frank J Palella, Ned Sacktor, Eric N Miller, Todd T Brown, James T Becker
The combined effects of human immunodeficiency virus (HIV), obesity, and elevated visceral adipose tissue (VAT) on brain structure are unknown. In a cross-sectional analysis of Multicenter AIDS Cohort Study (MACS) participants, we determined associations between HIV serostatus, adiposity, and brain structure. Men (133 HIV+, 84 HIV-) in the MACS Cardiovascular 2 and magnetic resonance imaging (MRI) sub-studies with CT-quantified VAT and whole brain MRI measured within 1 year were assessed. Voxel-based morphometry analyzed brain volumes...
December 15, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27940258/evolution-of-structural-abnormalities-in-the-rat-brain-following-in-utero-exposure-to-maternal-immune-activation-a-longitudinal-in-vivo-mri-study
#17
William R Crum, Stephen J Sawiak, Winfred Chege, Jonathan D Cooper, Steven C R Williams, Anthony C Vernon
Genetic and environmental risk factors for psychiatric disorders are suggested to disrupt the trajectory of brain maturation during adolescence, leading to the development of psychopathology in adulthood. Rodent models are powerful tools to dissect the specific effects of such risk factors on brain maturational profiles, particularly when combined with Magnetic Resonance Imaging (MRI; clinically comparable technology). We therefore investigated the effect of maternal immune activation (MIA), an epidemiological risk factor for adult-onset psychiatric disorders, on rat brain maturation using atlas and tensor-based morphometry analysis of longitudinal in vivo MR images...
December 9, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27893017/evaluation-of-cognitive-deficits-and-structural-hippocampal-damage-in-encephalitis-with-leucine-rich-glioma-inactivated-1-antibodies
#18
Carsten Finke, Harald Prüss, Josephine Heine, Sigrid Reuter, Ute A Kopp, Florian Wegner, Florian Then Bergh, Sebastian Koch, Olav Jansen, Thomas Münte, Günther Deuschl, Klemens Ruprecht, Winfried Stöcker, Klaus-Peter Wandinger, Friedemann Paul, Thorsten Bartsch
Importance: Limbic encephalitis with leucine-rich, glioma-inactivated 1 (LGI1) antibodies is one of the most frequent variants of autoimmune encephalitis with antibodies targeting neuronal surface antigens. However, the neuroimaging pattern and long-term cognitive outcome are not well understood. Objective: To study cognitive outcome and structural magnetic resonance imaging (MRI) alterations in patients with anti-LGI1 encephalitis. Design, Setting, and Participants: A cross-sectional study was conducted at the Departments of Neurology at Charité-Universitätsmedizin Berlin and University Hospital Schleswig-Holstein, Kiel, Germany...
January 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/27888657/electroconvulsive-therapy-induced-brain-structural-and-functional-changes-in-major-depressive-disorders-a-longitudinal-study
#19
Haitang Qiu, Xirong Li, Wenjing Zhao, Lian Du, Peiyu Huang, Yixiao Fu, Tian Qiu, Peng Xie, Huaqing Meng, Qinghua Luo
BACKGROUND This study aimed to study the brain structural and functional changes after 8 courses of electroconvulsive therapy (ECT) on patients with major depressive disorder (MDD). MATERIAL AND METHODS MRI scans were performed on 12 depressive patients before and after 8 courses of ECT and compared with those of 15 normal controls. Data were analyzed by voxel-based morphometry (VBM) using SPM8 software. Functional MRI (fMRI) and regional homogeneity (ReHo) analyses were used to assess the functional changes after ECT...
November 26, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27833805/whole-brain-ex-vivo-quantitative-mri-of-the-cuprizone-mouse-model
#20
Tobias C Wood, Camilla Simmons, Samuel A Hurley, Anthony C Vernon, Joel Torres, Flavio Dell'Acqua, Steve C R Williams, Diana Cash
Myelin is a critical component of the nervous system and a major contributor to contrast in Magnetic Resonance (MR) images. However, the precise contribution of myelination to multiple MR modalities is still under debate. The cuprizone mouse is a well-established model of demyelination that has been used in several MR studies, but these have often imaged only a single slice and analysed a small region of interest in the corpus callosum. We imaged and analyzed the whole brain of the cuprizone mouse ex-vivo using high-resolution quantitative MR methods (multi-component relaxometry, Diffusion Tensor Imaging (DTI) and morphometry) and found changes in multiple regions, including the corpus callosum, cerebellum, thalamus and hippocampus...
2016: PeerJ
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